CN105496924A - Toothpaste for treating periodontitis - Google Patents

Toothpaste for treating periodontitis Download PDF

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Publication number
CN105496924A
CN105496924A CN201510972235.1A CN201510972235A CN105496924A CN 105496924 A CN105496924 A CN 105496924A CN 201510972235 A CN201510972235 A CN 201510972235A CN 105496924 A CN105496924 A CN 105496924A
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rhizoma
herba
radix
toothpaste
medicine composition
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刘思娟
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
    • A61K36/126—Drynaria
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The invention provides toothpaste for treating periodontitis. The toothpaste comprises glycerin, carboxymethyl cellulose, saccharin, urea, calcium carbonate, lauryl sodium sulfate, essence, a traditional Chinese medicine composition extracting solution for treating periodontitis and distilled water. The traditional Chinese medicine composition in the toothpaste can activate the defensive function of a human body, can promote regeneration and healing of periodontium, has good compliance, a definite curative effect and few side effects, is low in cost, cannot cause the adverse reaction that the drug resistance of periodontal anaerobic bacteria is increased, and is worth popularization and application.

Description

Be used for the treatment of the toothpaste of periodontitis
Technical field
The present invention relates to cosmetics of everyday use technical field, particularly relate to a kind of toothpaste being used for the treatment of periodontitis.
Background technology
Periodontitis, because of complexity, is the first reason that adult loses tooth.According to the investigation of Third National oral health epidemiological, in current China adult, 80% ~ 97% suffers from periodontal in various degree, and within 35 years old, later prevalence obviously increases, within 40 ~ 50 years old, peak, and cause of disease complexity is various, individual variation is large, effects a radical cure more difficult.Periodontal treatment is based on topical therapeutic, and namely adopt the methods such as scaling, subgingival debridement, periodontal surgery on gum to remove the granulation tissue of periodontal pocket inwall, the alveolar bone of finishing pathological changes, creates conditions for periodontal adheres to again.Whole body uses antibacterials to kill and invades the in-house microorganism of periodontal wall, act at the bottom of dark periodontal pocket and the unapproachable region of curettage instrument such as furcation area, eliminate in oral cavity and remove periodontal pocket with some pathogenic microorganism of exterior domain, prevent pathogen from regenerating field planting in bag and damage recurrence of causing a disease.Used merely topical therapeutic and whole body anti-inflammatory treatment in the past, can only temporary relief of symptoms, can not frequent recurrence be stoped, and often can have side effects, as anaphylaxis, gastrointestinal irritation, leukocyte reduce.
Treatment by Chinese herbs periodontitis emphasizes integral viewpoint, and the basis regulating host immune response reaches the object of disease therapy.Traditional Chinese medical herbal treatment determined curative effect, toxic and side effects is few, and expense is low, and is easy to be accepted by patient.
The traditional Chinese medical science thinks the pathogenesis mainly stomach internal organs accumulated heat of periodontitis, and positive naked light is vehement, damp and hotly fumigates in upper and form gingival atrophy; Nephrons is deficient, kidney governing bones, tooth being the surplus of the bone, deficiency of the kidney, can not on reach, tooth loses and moistens foster, causes odontoseisis, gingival atrophy; Deficiency of qi and blood, gums loses supports, and pathogenic factor is invaded, and visitor causes gingival hemorrhage, atrophy, root of the tooth to appear, loosen between cog.The understanding of Chinese medical discrimination to its cause of disease is summarized as that oral cavity is unclean, gastrointestinal accumulated heat, deficient qi and blood and kidney qi loss, and being familiar with very early suffers from a deficiency of the kidney can cause periodontitis.Say in " General Treatise on the Cause and Symptoms of Diseases " " eventually, the institute of marrow is supported in the institute of tooth person kidney ".Qing Dynasty's Zhang Jingyue is thought in Jing-Yue Complete Works " renal failure then tooth is fallen, and the solid then tooth of essence is hard ".The prestige title " lower to toothache, many genus brothers Yang Ming bis-warps, the event of gastric heat hyperactivity of fire " of Qing Dynasty's force.Therefore, treatment on clearing stomach pathogenic fire reducing, removing toxic substances and promoting subsidence of swelling, cooling blood for hemostasis, enriching yin and nourishing kidney, hard bone teeth consolidating, invigorating blood circulation analgesia for principle.
By impact that is green, healthy consumption theory, Chinese herbal medicine concept has become the focus of Chinese toothpaste industry.On domestic market, the toothpaste of 40% ~ 50% declares it is Chinese herbal toothpaste, and market sale total value is greatly about about 5,000,000,000 yuan.
The invention provides a kind of toothpaste containing medicinal herb components being used for the treatment of periodontitis, its medicinal herb components comprised can transfer the defensive enginery of body, promote reconstruction and the healing of periodontal tissue, compliance is good, determined curative effect, side reaction are few, cheap, the untoward reaction that the drug resistance that can not produce periodontal anaerobe rises, is worthy of popularization.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of toothpaste being used for the treatment of periodontitis, the Chinese medicine composition extract component that this toothpaste contains can transfer the defensive enginery of body, promote reconstruction and the healing of periodontal tissue, compliance is good, determined curative effect, side reaction are few, cheap, the untoward reaction that the drug resistance that can not produce periodontal anaerobe rises, is worthy of popularization.
For solving the problems of the technologies described above, the invention provides a kind of toothpaste being used for the treatment of periodontitis, it comprises glycerol, carboxymethyl cellulose, glucide, carbamide, calcium carbonate, sodium lauryl sulphate, essence, the traditional Chinese medicine composition extract liquid being used for the treatment of periodontitis and distilled water.
Wherein, the weight of each raw material is respectively the distilled water of glycerol 15g ~ 20g, carboxymethyl cellulose 1g ~ 1.5g, glucide 1g ~ 1.5g, carbamide 2g ~ 4g, calcium carbonate 30g ~ 35g, sodium lauryl sulphate 1g ~ 3g, essence 1g ~ 1.5g, traditional Chinese medicine composition extract liquid 15g ~ 20g and surplus, and the quality sum of each raw material is 100g.
Wherein, the crude drug of described traditional Chinese medicine composition extract liquid comprises Radix Adenophorae, Folium Isatidis, Rhizoma Panacis Majoris, Semen Myristicae, Fructus Gardeniae, Rhizoma Coptidis, Fructus Corni, Rhizoma Dioscoreae, Semen Euryales, Caulis Sargentodoxae, Galla Chinensis, Radix Scrophulariae, Rhizoma Drynariae, Radix et Rhizoma Rhei Franzenbachii, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Radix Caesalpiniae Radicis, Herba Pyrolae, the Rhizoma Anemarrhenae, Chinese enkianthus, Fructus Broussonetiae, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) and Herba Fimbristylis dichotomae.
Wherein, in traditional Chinese medicine composition extract liquid, the weight of each crude drug is respectively Radix Adenophorae 30g ~ 40g, Folium Isatidis 55g ~ 65g, Rhizoma Panacis Majoris 35g ~ 45g, Semen Myristicae 30g ~ 40g, Fructus Gardeniae 25g ~ 35g, Rhizoma Coptidis 30g ~ 40g, Fructus Corni 35g ~ 45g, Rhizoma Dioscoreae 20g ~ 30g, Semen Euryales 20g ~ 30g, Caulis Sargentodoxae 25g ~ 35g, Galla Chinensis 30g ~ 40g, Radix Scrophulariae 20g ~ 30g, Rhizoma Drynariae 40g ~ 50g, Radix et Rhizoma Rhei Franzenbachii 15g ~ 25g, Herba Rabdosiae glaucocalycis 15g ~ 25g, Herba Asteris Ageratoidis 10g ~ 20g, Radix Caesalpiniae Radicis 10g ~ 20g, Herba Pyrolae 20g ~ 30g, Rhizoma Anemarrhenae 25g ~ 35g, Chinese enkianthus 10g ~ 20g, Fructus Broussonetiae 20g ~ 30g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 25g ~ 35g and Herba Fimbristylis dichotomae 20g ~ 30g.
Wherein, in traditional Chinese medicine composition extract liquid, the weight of each crude drug is respectively Radix Adenophorae 35g ~ 40g, Folium Isatidis 60g ~ 65g, Rhizoma Panacis Majoris 40g ~ 45g, Semen Myristicae 35g ~ 40g, Fructus Gardeniae 30g ~ 35g, Rhizoma Coptidis 35g ~ 40g, Fructus Corni 40g ~ 45g, Rhizoma Dioscoreae 25g ~ 30g, Semen Euryales 25g ~ 30g, Caulis Sargentodoxae 30g ~ 35g, Galla Chinensis 35g ~ 40g, Radix Scrophulariae 25g ~ 30g, Rhizoma Drynariae 45g ~ 50g, Radix et Rhizoma Rhei Franzenbachii 15g ~ 20g, Herba Rabdosiae glaucocalycis 15g ~ 20g, Herba Asteris Ageratoidis 10g ~ 15g, Radix Caesalpiniae Radicis 10g ~ 15g, Herba Pyrolae 20g ~ 25g, Rhizoma Anemarrhenae 25g ~ 30g, Chinese enkianthus 10g ~ 15g, Fructus Broussonetiae 20g ~ 25g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 25g ~ 30g and Herba Fimbristylis dichotomae 20g ~ 25g.
Wherein, in traditional Chinese medicine composition extract liquid, the weight of each crude drug is respectively Radix Adenophorae 35g, Folium Isatidis 60g, Rhizoma Panacis Majoris 40g, Semen Myristicae 35g, Fructus Gardeniae 30g, Rhizoma Coptidis 35g, Fructus Corni 40g, Rhizoma Dioscoreae 25g, Semen Euryales 25g, Caulis Sargentodoxae 30g, Galla Chinensis 35g, Radix Scrophulariae 25g, Rhizoma Drynariae 45g, Radix et Rhizoma Rhei Franzenbachii 20g, Herba Rabdosiae glaucocalycis 20g, Herba Asteris Ageratoidis 15g, Radix Caesalpiniae Radicis 15g, Herba Pyrolae 25g, Rhizoma Anemarrhenae 30g, Chinese enkianthus 15g, Fructus Broussonetiae 25g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 30g and Herba Fimbristylis dichotomae 25g.
Present invention also offers the preparation method of above-mentioned toothpaste, be specially:
The first step, prepares described traditional Chinese medicine composition extract liquid;
Second step, glycerol, carboxymethyl cellulose, sodium lauryl sulphate and water are mixed by weight ratio, boil in a kettle., temperature is 80 DEG C ~ 100 DEG C, is cooked into jelly, slightly treats coldly use;
3rd step, the traditional Chinese medicine composition extract liquid first step prepared and all the other components are put in reactor one by one, stir 2 ~ 3h, make the abundant mix homogeneously of various material, then lower the temperature gradually;
4th step, is cooled to 40 DEG C ~ 50 DEG C by material, Chan is thin, is cooled to 35 DEG C ~ 40 DEG C, and sealing is preserved, and obtains toothpaste.
The preparation method of described traditional Chinese medicine composition extract liquid, is specially:
The first step, get Radix Adenophorae, Folium Isatidis, Rhizoma Panacis Majoris, Rhizoma Coptidis, Fructus Corni, Rhizoma Dioscoreae, Galla Chinensis, Radix Scrophulariae, Rhizoma Drynariae, Radix et Rhizoma Rhei Franzenbachii, Herba Pyrolae and Chinese enkianthus, mix by described weight, be ground into 100 object powder, be 35 ~ 45MPa at pressure, temperature is under 45 ~ 55 DEG C of conditions, adopts supercritical CO 2extract 1.5 ~ 2.5 hours, collect extract, extract adds determining alcohol 70 ~ 80% ethanol, is heated to 50 ~ 70 DEG C, constantly stirs, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, and separates out precipitation, filter, concentrating under reduced pressure, dry, pulverize into 200 object powder;
Second step, by remaining components by described weight mixing, obtain mixture, be ground into 100 object powder, be placed in the container of sealing, add the water relative to 2 ~ 4 times, mixture, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, the powder that the first step obtains is joined in this filtrate, concentrating under reduced pressure, obtain the extracting solution of 0.5g/ml.
Beneficial effect of the present invention:
The toothpaste being used for the treatment of periodontitis provided by the invention can transfer the defensive enginery of body, promote the reconstruction of periodontal tissue and healing, compliance is good, determined curative effect, side reaction be few, cheap, the untoward reaction that the drug resistance that can not produce periodontal anaerobe rises, is worthy of popularization.
Detailed description of the invention
The invention provides a kind of toothpaste being used for the treatment of periodontitis, it comprises glycerol, carboxymethyl cellulose, glucide, carbamide, calcium carbonate, sodium lauryl sulphate, essence, the traditional Chinese medicine composition extract liquid being used for the treatment of periodontitis and distilled water.
The weight of each raw material is respectively the distilled water of glycerol 15g ~ 20g, carboxymethyl cellulose 1g ~ 1.5g, glucide 1g ~ 1.5g, carbamide 2g ~ 4g, calcium carbonate 30g ~ 35g, sodium lauryl sulphate 1g ~ 3g, essence 1g ~ 1.5g, traditional Chinese medicine composition extract liquid 15g ~ 20g and surplus, and the quality sum of each raw material is 100g.
Further preferably, the weight of each raw material is respectively the distilled water of glycerol 18g, carboxymethyl cellulose 1.2g, glucide 1.2g, carbamide 3g, calcium carbonate 32g, sodium lauryl sulphate 2g, essence 1.2g, traditional Chinese medicine composition extract liquid 18g and surplus, and the quality sum of each raw material is 100g.
The crude drug of traditional Chinese medicine composition extract liquid comprises Radix Adenophorae, Folium Isatidis, Rhizoma Panacis Majoris, Semen Myristicae, Fructus Gardeniae, Rhizoma Coptidis, Fructus Corni, Rhizoma Dioscoreae, Semen Euryales, Caulis Sargentodoxae, Galla Chinensis, Radix Scrophulariae, Rhizoma Drynariae, Radix et Rhizoma Rhei Franzenbachii, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Radix Caesalpiniae Radicis, Herba Pyrolae, the Rhizoma Anemarrhenae, Chinese enkianthus, Fructus Broussonetiae, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) and Herba Fimbristylis dichotomae.
Further, the crude drug of described traditional Chinese medicine composition extract liquid is only made up of above-mentioned raw materials medicine.
In described traditional Chinese medicine composition extract liquid, the weight of each crude drug is respectively Radix Adenophorae 30g ~ 40g, Folium Isatidis 55g ~ 65g, Rhizoma Panacis Majoris 35g ~ 45g, Semen Myristicae 30g ~ 40g, Fructus Gardeniae 25g ~ 35g, Rhizoma Coptidis 30g ~ 40g, Fructus Corni 35g ~ 45g, Rhizoma Dioscoreae 20g ~ 30g, Semen Euryales 20g ~ 30g, Caulis Sargentodoxae 25g ~ 35g, Galla Chinensis 30g ~ 40g, Radix Scrophulariae 20g ~ 30g, Rhizoma Drynariae 40g ~ 50g, Radix et Rhizoma Rhei Franzenbachii 15g ~ 25g, Herba Rabdosiae glaucocalycis 15g ~ 25g, Herba Asteris Ageratoidis 10g ~ 20g, Radix Caesalpiniae Radicis 10g ~ 20g, Herba Pyrolae 20g ~ 30g, Rhizoma Anemarrhenae 25g ~ 35g, Chinese enkianthus 10g ~ 20g, Fructus Broussonetiae 20g ~ 30g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 25g ~ 35g and Herba Fimbristylis dichotomae 20g ~ 30g.
Further, in described traditional Chinese medicine composition extract liquid, the weight of each crude drug is respectively Radix Adenophorae 35g ~ 40g, Folium Isatidis 60g ~ 65g, Rhizoma Panacis Majoris 40g ~ 45g, Semen Myristicae 35g ~ 40g, Fructus Gardeniae 30g ~ 35g, Rhizoma Coptidis 35g ~ 40g, Fructus Corni 40g ~ 45g, Rhizoma Dioscoreae 25g ~ 30g, Semen Euryales 25g ~ 30g, Caulis Sargentodoxae 30g ~ 35g, Galla Chinensis 35g ~ 40g, Radix Scrophulariae 25g ~ 30g, Rhizoma Drynariae 45g ~ 50g, Radix et Rhizoma Rhei Franzenbachii 15g ~ 20g, Herba Rabdosiae glaucocalycis 15g ~ 20g, Herba Asteris Ageratoidis 10g ~ 15g, Radix Caesalpiniae Radicis 10g ~ 15g, Herba Pyrolae 20g ~ 25g, Rhizoma Anemarrhenae 25g ~ 30g, Chinese enkianthus 10g ~ 15g, Fructus Broussonetiae 20g ~ 25g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 25g ~ 30g and Herba Fimbristylis dichotomae 20g ~ 25g.
Most preferably, in described traditional Chinese medicine composition extract liquid, the weight of each crude drug is respectively Radix Adenophorae 35g, Folium Isatidis 60g, Rhizoma Panacis Majoris 40g, Semen Myristicae 35g, Fructus Gardeniae 30g, Rhizoma Coptidis 35g, Fructus Corni 40g, Rhizoma Dioscoreae 25g, Semen Euryales 25g, Caulis Sargentodoxae 30g, Galla Chinensis 35g, Radix Scrophulariae 25g, Rhizoma Drynariae 45g, Radix et Rhizoma Rhei Franzenbachii 20g, Herba Rabdosiae glaucocalycis 20g, Herba Asteris Ageratoidis 15g, Radix Caesalpiniae Radicis 15g, Herba Pyrolae 25g, Rhizoma Anemarrhenae 30g, Chinese enkianthus 15g, Fructus Broussonetiae 25g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 30g and Herba Fimbristylis dichotomae 25g.
Fang Zhong, Radix Adenophorae yin nourishing pathogenic fire reducing, Folium Isatidis heat-clearing and toxic substances removing, and the effect having light a surname evacuation, Rhizoma Panacis Majoris reducing swelling and alleviating pain, hemostasis, antibacterial, and can enhancing human body immunity power, improve local blood circulation, reduce inflammatory exudation, promote epithelial repair, Semen Myristicae acrid in the mouth wets, and function is warming middle-JIAO to send down the adverse QI, warming the kidney to activate YANG, Fructus Gardeniae lets out clearly the fire of liver and gall, and Rhizoma Coptidis clears away heart-fire the fire of stomach, and bitter cold directly rolls over its heat, Fructus Corni liver and kidney tonifying, Chinese yam spleen-strengtheningporridge tonifying the lung, stomach reinforcing the kidney invigorating, Semen Euryales reinforcing the kindey to control nocturnal emission, spleen reinforcing stopping leak, and Caulis Sargentodoxae relieves internal heat eliminating carbuncle, wind dispelling insecticide, and Galla Chinensis is astringed the lung pathogenic fire reducing, removing toxic substances sore, Radix Scrophulariae clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, Radix et Rhizoma Rhei Franzenbachii purges heat removing toxic substances, removing heat from blood clots absorbing, Herba Rabdosiae glaucocalycis clearing away heat-damp and promoting diuresis, promoting blood circulation and detoxication, Herba Asteris Ageratoidis thermal detoxification, and eliminate the phlegm removing heat from blood, Radix Caesalpiniae Radicis removing toxic substances and promoting subsidence of swelling, Herba Pyrolae promoting blood flow to regulate menstruation, the kidney invigorating bone strengthening, Rhizoma Drynariae the kidney invigorating bone strengthening, continue and hinder pain relieving, the Rhizoma Anemarrhenae rushes down stomach-fire clearly, to purge heat relieving restlessness, Chinese enkianthus eliminating stasis to stop pain, inducing diuresis to remove edema, Herba Alternantherae sessilis cool the blood dissipate blood stasis, heat-clearing and toxic substances removing, Fructus Broussonetiae the kidney invigorating liver heat removing, improving eyesight diuresis, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling, Herba Fimbristylis dichotomae heat-clearing and toxic substances removing, and diuresis sterilizes, and all medicines share, and play clearing stomach pathogenic fire reducing altogether, removing toxic substances and promoting subsidence of swelling, cooling blood for hemostasis, enriching yin and nourishing kidney, hard bone teeth consolidating, the merit of invigorating blood circulation analgesia.
Radix Adenophorae: sweet in the mouth, micro-hardship, cold nature, enter lung, stomach warp, there is nourishing the lung to arrest cough, the effect of nourishing the stomach to promote the production of body fluid, be mainly used in lung-dryness syndrome due to deficiency of YIN, dry cough few expectorant, chronic cough expectorant blood, the cards such as the few tongue of deficiency of stomach-Yin, mouthfeel parched throat, constipation, red tongue, cellular immunization and non-specific immunity can be improved, suppress humoral immunization, there is the function of immunity moderation balance.
Folium Isatidis: latin name IsatidisFolium, bitter in the mouth, property Great Cold, GUIXIN, liver, gallbladder, stomach warp, have antipyretic and detoxicated, cooling blood and dissolving purpura, effect of jaundice eliminating, can the excess-heat that divides of clearing heat in QI system, can separate again the pyretic toxicity of blood system, the high febrile perspiration being mainly used in pestilence calentura caused goes out, excessive thirst taking fluids profusely; The speckle that fire-toxin is flourishing is gone mad, the symptoms such as haematemesis; The unconsciousness due to high fever of measles, rash color is purple dark; Dampness-heat in the liver and gallbladder accumulates the jaundice of steaming; The deafness and tinnitus of liver and gall fire liter; The card such as pharyngalgia, aphtha of the mouth and tongue, hepatitis that fire stagnation pyretic toxicity is caused.
Rhizoma Panacis Majoris: bitter in the mouth, sweet, cold nature, enters liver, lung, stomach warp, have tonifying the lung yin nourishing, dissipating blood stasis stops blooding, the effect of reducing swelling and alleviating pain,, cough due to consumptive disease thirsty for deficiency of both QI and YIN, excessive thirst, various hemorrhage, as haematemesis, hemoptysis, have blood in stool, hematuria, metrorrhagia, traumatic injury wound is swollen, rheumatic arthritis, stomachache, acute toothache, laryngopharynx swelling and pain, the cards such as sore and toxic.
Semen Myristicae: latin name myristicaesemen, acrid in the mouth, hardship, warm in nature, enter spleen, stomach, large intestine channel, there is the effect of warming middle-JIAO astringing intestine to stop diarrhea, promote qi circulation digestion promoting, the card such as not disappear for diarrhea of deficiency type, cold-dysentery, abdominal distention, lack of appetite vomiting, dyspepsia.
Fructus Gardeniae: latin name gardeniaefructus, bitter in the mouth, cold in nature, enter the heart, lung, three burnt, have the effect of relieving restlessness pathogenic fire purging, dispersing the stagnated live-QI to relieve the stagnation of QI, clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, be mainly used in the vexed uneasiness of epidemic febrile disease heat stagnation breast gastral cavity, bother not peaceful; Hot and suffocating in stomach, the lips are dry and the mouth is parched, aphtha halitosis; Stagnation of liver-QI is not relaxed or Liver Channel has having a dizzy spell of heat, pain in chest and hypochondrium, conjunctival congestion dry pharynx; Jaundice due to damp-heat; The cards such as the abdominal distention of qi depression to blood stasis.
Rhizoma Coptidis: bitter in the mouth, cold in nature, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel, have effect of heat-clearing and toxic substances removing, eliminating fire and detoxication, parasite killing, for damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle, external treatment eczema, eczema, auditory meatus such as to be suppurated at the card.
Fructus Corni: latin name cornifructus, sour in the mouth, puckery, slightly warm in nature, returns liver, kidney channel, has effect of liver and kidney tonifying, arresting collape syndrome by astringents, cures mainly vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, and profuse sweating is collapsed, and interior-heat such as to be quenched one's thirst at the card.
Rhizoma Dioscoreae: latin name dioscoreaerhizoma, sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red card such as swollen, fat of frequent micturition of quenching one's thirst, premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.
Rhizoma Drynariae: bitter in the mouth, warm in nature, enter kidney, Liver Channel, have the kidney invigorating bone strengthening, continuous effect of hindering pain relieving, is used for the treatment of suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, the cards such as clavus.
Semen Euryales: sweet in the mouth, puckery, property is put down, and return spleen, kidney channel, have reinforcing the kindey to control nocturnal emission, effect of spleen reinforcing stopping leak, cures mainly seminal emission, stranguria with turbid discharge, leukorrhagia, incontinence of urine, the cards such as loose stool and diarrhea.
Herba Pyrolae: sweet in the mouth, hardship, warm in nature, enter lung meridian, stomach warp, Liver Channel, kidney channel, can tonify deficiency, kidney tonifying, expelling wind and removing dampness, promoting blood flow to regulate menstruation, the kidney invigorating bone strengthening, expelling wind and removing dampness, cough-relieving, hemostasis, cure mainly main lumbago due to renal deficiency, rheumatic arthralgia, soft, the new chronic cough of muscles and bones flaccidity coughed, spit blood, epistaxis, metrorrhagia, traumatic hemorrhage.
The Rhizoma Anemarrhenae: be plant amedica, bitter in the mouth, sweet, cold in nature, enter lung, stomach, kidney channel, have rush down clearly stomach-fire, relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, cure mainly fever caused by exogenous pathogenic factors, high heat is irritated, lung-heat type cough, and interior-heat such as to be quenched one's thirst at the symptom; Its bitter cold matter is moistened, and property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also diabetes is used for the treatment of; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire, the Rhizoma Anemarrhenae has inhibitory action to various bacteria such as dysentery bacterium, Bacillus typhi, escherichia coli, Bacillus proteus, staphylococcus, streptococcus.
Chinese enkianthus: be tuber and the root of Ericaceae Agapetes plant Chinese enkianthus, cool in nature, bitter and puckery flavor, has eliminating stasis to stop pain, and effect of inducing diuresis to remove edema, cures mainly traumatic injury, rheumatic ostalgia, stomachache, hepatitis, edema, the cards such as innominate toxic swelling.
Herba Alternantherae sessilis: sweet in the mouth, cold in nature, have cool the blood dissipate blood stasis, heat-clearing and toxic substances removing, dehumidify treating stranguria card such as grade, cures mainly hemoptysis, spit blood, have blood in stool, jaundice due to damp-heat, the cards such as dysentery, has loose bowels, gingival swelling and pain, laryngopharynx swelling and pain, acute mastitis, swollen ulcer drug, traumatic injury, venom.
Fructus Broussonetiae: sweet in the mouth, cold in nature, return liver, kidney channel, there is the kidney invigorating liver heat removing, effect of improving eyesight diuresis, cure mainly deficiency of the liver and kindey, soreness of the waist and knees, asthenia hectic fever due to YIN-deficiency, have a dizzy spell, the card such as edema distension.
Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.): latin name AjugaeHerba is hardship, cold in nature, returns lung meridian, has effect of heat-clearing and toxic substances removing, removing heat from blood detumescence, cures mainly laryngopharynx swelling and pain, lung-heat hemoptysis, the cards such as traumatic injury pain.
Herba Fimbristylis dichotomae: sweet in the mouth, micro-puckery, cool in nature, have removing toxic substances, diuresis, effect of sterilization, cures mainly rheumatic arthritis, urinary tract infection, parasitosis.
Caulis Sargentodoxae: bitter in the mouth, property is put down, and returns liver, large intestine channel, has the eliminating carbuncle that relieves internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, cure mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, the cards such as injury from falling down.
Galla Chinensis: latin name GallaChinensis, sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, there is effect of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming, cure mainly: chronic cough of deficiency lung; Spontaneous sweating; Chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; The cards such as carbuncle furuncle.
Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature, returns lung, stomach, kidney channel, have clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing supports effect of kidney, cure mainly pathogenic warmth to join the army, cave in pericardium, maculae caused by violent heat pathogen, and consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin hinder the cards such as constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.
Radix et Rhizoma Rhei Franzenbachii: latin name RadixetRhizomeRheiFranzenbachii is the root and rhizome of polygonaceae plant rheum rhabarbarum, bitter in the mouth; Cold in nature, return stomach; Large intestine channel, has removing toxic substances of purging heat; Effect of removing heat from blood clots absorbing, cures mainly jaundice due to damp-heat; Dysentery; Amenorrhea is suffered from abdominal pain; Hematemesis and epistaxis; Traumatic injury stasis of blood pain; Carbuncle furunculosis; Aphthous stomatitis; The cards such as burn and scald.
Herba Rabdosiae glaucocalycis: bitter in the mouth, pungent, gas is fragrant, and cool in nature, GUIXIN, liver, spleen channel, have clearing away heat-damp and promoting diuresis, and effect of promoting blood circulation and detoxication, cures mainly jaundice due to damp-heat, stranguria, edema, laryngopharynx swelling and pain, arthralgia, amenorrhea, acute mastitis, hemorrhoid, traumatic injury, the cards such as venom.
Herba Asteris Ageratoidis: bitter in the mouth, pungent, cool in nature, have heat-clearing and toxic substances removing, the effect of the removing heat from blood that eliminates the phlegm, cures mainly cold, fever, tonsillitis, bronchitis, hepatitis, enteritis, pyretic stranguria, carbuncle furunculosis, the cards such as snake bite and insect sting.
Radix Caesalpiniae Radicis: bitter in the mouth, pungent, property is put down, and have expelling wind and removing dampness, effect of removing toxic substances and promoting subsidence of swelling, cures mainly cold, fever, cough, laryngopharynx swelling and pain, toothache, rheumatic arthralgia, hepatitis, dysentery, stranguria, skin pruritus, the cards such as venom.
The preparation method of described traditional Chinese medicine composition extract liquid, is specially:
The first step, get Radix Adenophorae, Folium Isatidis, Rhizoma Panacis Majoris, Rhizoma Coptidis, Fructus Corni, Rhizoma Dioscoreae, Galla Chinensis, Radix Scrophulariae, Rhizoma Drynariae, Radix et Rhizoma Rhei Franzenbachii, Herba Pyrolae and Chinese enkianthus, mix by described weight, be ground into 100 object powder, be 35 ~ 45MPa at pressure, temperature is under 45 ~ 55 DEG C of conditions, adopts supercritical CO 2extract 1.5 ~ 2.5 hours, collect extract, extract adds determining alcohol 70 ~ 80% ethanol, is heated to 50 ~ 70 DEG C, constantly stirs, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, and separates out precipitation, filter, concentrating under reduced pressure, dry, pulverize into 200 object powder;
Second step, by remaining components by described weight mixing, obtain mixture, be ground into 100 object powder, be placed in the container of sealing, add the water relative to 2 ~ 4 times, mixture, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, the powder that the first step obtains is joined in this filtrate, concentrating under reduced pressure, obtain the extracting solution of 0.5g/ml.
Present invention also offers the preparation method of above-mentioned toothpaste, be specially:
The first step, prepares described traditional Chinese medicine composition extract liquid;
Second step, glycerol, carboxymethyl cellulose, sodium lauryl sulphate and water are mixed by weight ratio, boil in a kettle., temperature is 80 DEG C ~ 100 DEG C, is cooked into jelly, slightly treats coldly use;
3rd step, the traditional Chinese medicine composition extract liquid first step prepared and all the other components are put in reactor one by one, stir 2 ~ 3h, make the abundant mix homogeneously of various material, then lower the temperature gradually;
4th step, is cooled to 40 DEG C ~ 50 DEG C by material, Chan is thin, is cooled to 35 DEG C ~ 40 DEG C, and sealing is preserved, and obtains toothpaste.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
The preparation of embodiment 1 traditional Chinese medicine composition extract liquid 1
Get Radix Adenophorae 35g, Folium Isatidis 60g, Rhizoma Panacis Majoris 40g, Rhizoma Coptidis 35g, Fructus Corni 40g, Rhizoma Dioscoreae 25g, Galla Chinensis 35g, Radix Scrophulariae 25g, Rhizoma Drynariae 45g, Radix et Rhizoma Rhei Franzenbachii 20g, Herba Pyrolae 25g and Chinese enkianthus 15g, mix by described weight, be ground into 100 object powder, be 40MPa at pressure, temperature is under 50 DEG C of conditions, adopts supercritical CO 2extract 2 hours, collect extract, extract adds determining alcohol 80% ethanol, be heated to 60 DEG C, continuous stirring, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, separate out precipitation, filter, concentrating under reduced pressure, dry, be ground into 200 object powder, by Semen Myristicae 35g, Fructus Gardeniae 30g, Semen Euryales 25g, Caulis Sargentodoxae 30g, Herba Rabdosiae glaucocalycis 20g, Herba Asteris Ageratoidis 15g, Radix Caesalpiniae Radicis 15g, Rhizoma Anemarrhenae 30g, Fructus Broussonetiae 25g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 30g and Herba Fimbristylis dichotomae 25g is by described weight mixing, obtain mixture, be ground into 100 object powder, be placed in the container of sealing, add 900g water, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, the powder obtained above is joined in this filtrate, concentrating under reduced pressure, obtain the extracting solution 1 of 0.5g/ml.
The preparation of embodiment 2 traditional Chinese medicine composition extract liquid 2
Get Radix Adenophorae 40g, Folium Isatidis 65g, Rhizoma Panacis Majoris 45g, Rhizoma Coptidis 40g, Fructus Corni 45g, Rhizoma Dioscoreae 30g, Galla Chinensis 40g, Radix Scrophulariae 30g, Rhizoma Drynariae 50g, Radix et Rhizoma Rhei Franzenbachii 20g, Herba Pyrolae 25g and Chinese enkianthus 15g, mix by described weight, be ground into 100 object powder, be 40MPa at pressure, temperature is under 50 DEG C of conditions, adopts supercritical CO 2extract 2 hours, collect extract, extract adds determining alcohol 80% ethanol, be heated to 60 DEG C, continuous stirring, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, separate out precipitation, filter, concentrating under reduced pressure, dry, be ground into 200 object powder, by Semen Myristicae 40g, Fructus Gardeniae 35g, Semen Euryales 30g, Caulis Sargentodoxae 35g, Herba Rabdosiae glaucocalycis 20g, Herba Asteris Ageratoidis 15g, Radix Caesalpiniae Radicis 15g, Rhizoma Anemarrhenae 30g, Fructus Broussonetiae 25g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 30g and Herba Fimbristylis dichotomae 25g is by described weight mixing, obtain mixture, be ground into 100 object powder, be placed in the container of sealing, add 900g water, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, the powder obtained above is joined in this filtrate, concentrating under reduced pressure, obtain the extracting solution 2 of 0.5g/ml.
The preparation of embodiment 3 traditional Chinese medicine composition extract liquid 3
Get Radix Adenophorae 35g, Folium Isatidis 60g, Rhizoma Panacis Majoris 40g, Rhizoma Coptidis 35g, Fructus Corni 40g, Rhizoma Dioscoreae 25g, Galla Chinensis 35g, Radix Scrophulariae 25g, Rhizoma Drynariae 45g, Radix et Rhizoma Rhei Franzenbachii 15g, Herba Pyrolae 20g and Chinese enkianthus 10g, mix by described weight, be ground into 100 object powder, be 40MPa at pressure, temperature is under 50 DEG C of conditions, adopts supercritical CO 2extract 2 hours, collect extract, extract adds determining alcohol 80% ethanol, be heated to 60 DEG C, continuous stirring, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, separate out precipitation, filter, concentrating under reduced pressure, dry, be ground into 200 object powder, by Semen Myristicae 35g, Fructus Gardeniae 30g, Semen Euryales 25g, Caulis Sargentodoxae 30g, Herba Rabdosiae glaucocalycis 15g, Herba Asteris Ageratoidis 10g, Radix Caesalpiniae Radicis 10g, Rhizoma Anemarrhenae 25g, Fructus Broussonetiae 20g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 25g and Herba Fimbristylis dichotomae 20g is by described weight mixing, obtain mixture, be ground into 100 object powder, be placed in the container of sealing, add 900g water, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, the powder obtained above is joined in this filtrate, concentrating under reduced pressure, obtain the extracting solution 3 of 0.5g/ml.
Embodiment 4 toxicological experiment
Acute toxicity testing
Mice is divided at random test group and blank group, each 20.Before test after fasting (can't help water) 12h, the test group traditional Chinese medicine composition extract liquid 1 that every day is prepared by 1 gastric infusion embodiment 1, blank group is filled with to normal saline.Continuous 14d, the situations such as the behavior of record test mice, activity, food ration, body weight, feces, death, not dead mice is put to death and performs an autopsy on sb. after 14d.
The mice of drug test group 40g (crude drug)/kg dosed administration, saw that mice hair color was smooth, feces is brown the same day, quality is rarer soft, ingest, movable less, mice activity after 2nd day, food ration, body weight growth, feces etc. all recover normally, to compare no significant difference with blank group; And in 14d without dead and other extremely to occur, two groups put to death simultaneously after perform an autopsy on sb., each main organs (heart, liver, spleen, lung, kidney) no abnormality seen by the naked eye.
Long term toxicity test
Rat is divided at random test group and blank group, each 20.The test group traditional Chinese medicine composition extract liquid 1 that every day is prepared by 1 gastric infusion embodiment 1, the time of repetitively administered is 5 weeks, and test group dosage is 10g (crude drug)/kg.Experimental animal behavioral activity, diet, defecation and shown no obvious abnormalities by situations such as hair color pools within whole experimental period, have no vomiting, sialorrhea, shed tears, the symptom such as dyspnea.
The solution portion of rat main organs learns and observes: put to death animal after off-test, dissect immediately, the major organs such as perusal brain, heart, liver, spleen, lungs, kidney, each organ surface is smooth, without adhesion, color and luster is normal, has no hyperemia, swelling, hemorrhage, downright bad, adhesion, gastrointestinal is without expansion, and intestinal wall is without abnormal phenomenas such as edema, hemorrhage, ulcer.
Histopathologic examination's result
Heart: myocardial cell band is clear, core is placed in the middle, and interstitial has no vasodilation and cell infiltration; Visceral pericardium, endocardium are without exception.Liver: hepatocyte arrangement is in strand, and lobules of liver structure is clear, and portal area has no cell infiltration and fibrous connective tissue hypertrophy, hepatocyte polygon, and slurry is abundant, core is large and justify.Spleen: fibrous capsule is complete, without thickening, acini lienalis is high-visible, and trabecularism is normal, and red pulp, white pulp are clear, have no degeneration, necrosis and cell infiltration.Lungs: bronchioles structural integrity, is methodically arranged, alveolar wall structural integrity, lung interval and bronchus stand intact, and intracavity, without obvious exudate, has no degeneration, necrosis and cell infiltration.Kidney: Renal Cortex, medullary substance, glomerule structure are normal, and messangial cell number does not increase, blood capillary tube chamber without expansion, renal cells, renal interstitial no abnormality seen.Brain: organizational structure is normal, neurocyte, neurogliocyte form are normal, each layer neuronal cell Non Apparent Abnormality.
Irritation test
By healthy adult white, man exempts from 4, body weight 2.5 ~ 2.7kg, male and female half and half.By its spinal column both sides skin unhairing 3cm × 3cm, traditional Chinese medicine composition extract liquid 1 prepared by Example 1,2.5cm × 2.5cm bis-layers of gauze are immersed in 10min in this solution, be applied on a plucked skin in rabbit back side subsequently, cover with one deck cellophane, fixed with nonirritant medical proof fabric and binder, opposite side distilled water compares again.Every experimental animal is applied ointment or plaster after 4h, removes tested material, with the skin of warm water cleaning application site, respectively at 1,24,48h observes and records the dermoreaction of application site, the standards of grading specified according to " disinfection technology standard " and classification are marked.Irritation test shows, Chinese medicine dentifrice provided by the invention 1 pair of rabbit skin wound repair integration is 0, and skin, without erythema, belongs to non-stimulated.
The preparation of embodiment 5 toothpaste 1
Glycerol 18g, carboxymethyl cellulose 1.2g, sodium lauryl sulphate 2g and 23.6g water are mixed, boil in a kettle., temperature is 100 DEG C, be cooked into jelly, slightly treat coldly use, the traditional Chinese medicine composition extract liquid 1 18g embodiment 1 prepared and glucide 1.2g, carbamide 3g, calcium carbonate 32g, essence 1.2g put in reactor one by one, stir 3h, make the abundant mix homogeneously of various material, then lower the temperature gradually, material is cooled to 50 DEG C, Chan is thin, be cooled to 35 DEG C, sealing is preserved, and obtains toothpaste 1.
Embodiment 6 animal experiment
Cleaning grade male Wister rat, weight is 20 ~ 25g; Traditional Chinese medicine composition extract liquid 1 prepared by embodiment 1; Rat tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) ELISA kit (Wuhan doctor's moral bio-engineering corporation); 10% chloral hydrate (Shandong Qilu Pharmaceutical Factory, lot number: 141221); 0.9% normal saline (Kelun Pharm Ind Co., Ltd., Sichuan, lot number: 120918); Endotoxin: escherichia coli 0111, B4 strain lipopolysaccharide (ELPS), purchased from American Sigma company, periodontal probe; EDTA (Sigma company).
Modeling and grouping
By Wistar rat, with 10% chloral hydrate 0.3ml100g -1after anesthesia, get dorsal position, be fixed on Mus plate.With first molar cheek side, palate side gingiva on the left of the sharp separation upper jaw of probe, drip 1mg/ml endotoxin suspension each 10L in cheek, palate gingival pocket with syringe.Meanwhile, at the far mid-cotton pellet of this tooth, to absorb the endotoxin overflowing periodontal pocket, with antifouling rats breathing passage.With method modeling totally 3 times, each interval time 2d; Replace water to raise with the height sugar viscous liquid that the volume of milk, water and white sugar and mass ratio are 50:30:20 simultaneously.From the 3rd next day of modeling, dark red, rotten to the corn, the ulcer of first molar swelling and aching of gum on the left of the upper jaw, touch easily hemorrhage, there is obvious absorption in periodontal tissue, forms periodontal pocket.
Process of the test
Rat is divided into 3 groups at random, and often organize 20, the 1st group is blank group: normal diet is raised, and processes without any intervention.2nd group is model control group: set up Periodontitis Model, and the 3rd group is medicine group: after setting up Periodontitis Model, traditional Chinese medicine composition extract liquid 1 concentrating under reduced pressure embodiment 1 prepared, and removes solvent, obtains and get dry extract, be ground into powder, be applied in periodontitis place.
Drug therapy.Administration from modeling d2, the next day once.Medication is: with ether by Wistar rat anesthesia, pry open oral cavity, and powder prepared by traditional Chinese medicine composition extract liquid 1 is dipped in upper micro-normal saline, is applied in around animal periodontal pocket after forming pasty state, keeps animal light anaesthesia state to be about 30min.
At the end of experiment, get Rat Right artery of lower extremity blood, be isolated serum and plasma, the left maxillary alveolar bone of clip, tooth and surrounding tissue are placed in after 4% paraformaldehyde solution fixes 24h, take the photograph digital X-ray film, be placed in for 7% disodiumedetate liquid (EDTA) decalcification February again, embedding, for pathology detection.
The mensuration of biochemical indicator
The blood serum sample be separated under getting Animal Model and grouping item, carries out TNF-α by ELISA method, the mensuration of IL-6.
The mensuration of phatnoma bone height
Get the alveolar bone specimen level fixed, be placed on irradiation table, with identical projection condition shooting (to the distance at specimen center for 5.0cm, time of exposure is 0.1s at bulb center) digital X-ray film, and measure alveolar bone situation of change.In near with first molar, alveolar ridge crest is to the horizontal range of nearly middle root of the tooth minimum point, in this, as phatnoma bone height value.
Statistical method
All experimental datas with ± s represents, utilizes SPSS11.0 statistical software, its significance of t inspection inspection between employing group.
Result
Medicine on the impact of rat blood serum, in table 1.
Table 1 is on the impact of rat blood serum TNF-α and IL-6
Group Number of animals (n) TNF-α（ρ B/ng·mL －1） IL-6(ρ B/pg·mL －1)
Normal group 20 4.03 +0.62 15.93 +2.17 8 -->
Model group 20 8.93 +1.60 41.35 +5.29
Medicine group 20 5.02 +0.61 20.05 +2.21
The horizontal compared with normal group of table 1 display model group rat blood serum TNF-α and IL-6 obviously raises, and difference has statistical significance (P < 0.01), after Drug therapy, record TNF-α and IL-6 level all declines, and difference has statistical significance (P < 0.01), there is the effect suppressing inflammatory reaction in rat body significantly.
Medicine, on the impact of rat alveolar bone, the results are shown in Table 2.
Table 2 is on the impact of rat alveolar bone
Group Number of animals (n) Phatnoma bone height (l/mm)
Normal group 20 2.71 +0.30
Model group 20 1.43 +0.25
Medicine group 20 2.26 +0.31
Table 2 display model group rat alveolar bone height value compared with normal group declines obviously, and difference has statistical significance (P < 0.01), and after treatment rat alveolar bone height value comparatively model group have rising, and difference has statistical significance (P < 0.01).Illustrate that the forfeiture of medicine provided by the invention to rat alveolar bone height value is inhibited, also can suppress the generation of Periodontal Tissues of Rat Periodontitis pathological changes.
Embodiment 9 clinical data
150 routine cases are the out-patient between section office's in January, 2011 in JIUYUE ,-2013, are divided into treatment group and each 75 examples of matched group at random.Wherein treatment group man 39 example, female 36 example, matched group man 40 example, female 35 example; Treatment group patient with slight symptoms 26 example, moderate patient 29 example, patient with severe symptoms 20 example, matched group patient with slight symptoms 33 example, moderate patient 25 example, patient with severe symptoms 16 example.Two groups of patients through statistical analysis there was no significant difference (P < 0.05), have comparability in age, sex, disease severity etc.
Therapeutic Method
All give oral cavity conventional full mouth scaling before two groups of medications, filling cavity, can do gum lobe plasty and periodontal splint ligation fixation if desired, the toothpaste that treatment group uses embodiment 5 to prepare on this basis is brushed teeth, and examiner does not use other toothpaste tested period.Brush teeth every day 2 times, each 3min, matched group adopts shiny pricklyash toothpaste, brushes teeth every day 2 times, each 3min.Two groups was all 1 course for the treatment of with 1 month, 3 courses for the treatment of of Continuous Observation, was analyzed its clinical efficacy.
Observation index
Plaque index (PLI): the thickness of bacterial plaque and amount near essential record gum edge, does not see merely the distribution of bacterial plaque.With the method inspection of the bonding probes of inspection, inspection to row dry facing with probe, scores according to the amount of bacterial plaque and thickness.0 point: Yin Yuan district is without bacterial plaque; The facing in 1 point: Yin Yuan district has thin bacterial plaque, but inspection is invisible, if can hang up bacterial plaque with the side of probe pinpoint; 2 points: in gum edge or the visible moderate bacterial plaque of proximal surface; 3 points: gingival sulcus Nei Huoyinyuan district and proximal surface have a large amount of soft enough.Periodontal pocket is visited and is examined the degree of depth (pD): the distance that spy is examined at the bottom of gum edge to bag is in units of mm.Sulcular bleeding index (SBI): periodontal probe is gently visited about 1mm place to gum edge and slide gently, observe with or without hemorrhage and extent of hemorrhage, be divided into 4 grades, 1 point-not hemorrhage; 2 points-gingiva outward appearance is normal, hemorrhage during light spy gingival sulcus; 3 points-gingiva is red, without swelling, hemorrhage when detecting gingival sulcus; 4 points-gingiva has ulcer or other symptoms.
Statistical method
All experimental datas with ± s represents, utilizes SPSS11.0 statistical software, its significance of t inspection inspection between employing group.
Curative effect determinate standard
Effective: symptom is obviously improved, gingiva outward appearance is normal, periodontal hyperemia, edema, hemorrhage disappear or comparatively before alleviate, periodontal pocket disappears or partial disappearance, and tooth has slight loosening; Effective: remission, outward appearance is normal, periodontal hyperemia, edema, hemorrhage alleviation, and tooth still loosens; Invalid: unchanged before and after treatment.Total effective rate=(effective+effectively)/n × 100%.
Result
General curative effect compares, and the results are shown in Table 3.
A table 3 liang group general curative effect compares
Group n Effective Effectively Invalid Total effective rate
Treatment group 75 56 19 0 100%
Matched group 75 43 23 9 88%
As can be seen from Table 3, adopt Chinese medicine partner treatment mode provided by the invention and traditional conventional treatment regime therapeutic effect better, prove medicine provided by the invention Be very effective in treatment periodontitis.
Observation index result, in table 4.
A table 4 liang group observation index compares
Group Plaque index The pocket probe degree of depth (mm) Sulcular bleeding index
Treatment group 1.59 +0.36 1.82 +0.27 1.50 +0.13
Matched group 3.29 +0.71 3.89 +0.41 3.01 +0.29
As can be seen from Table 4, medicine provided by the invention is adopted to want significantly lower than matched group in plaque index, the pocket probe degree of depth, sulcular bleeding index.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. be used for the treatment of a toothpaste for periodontitis, it is characterized in that: comprise glycerol, carboxymethyl cellulose, glucide, carbamide, calcium carbonate, sodium lauryl sulphate, essence, the traditional Chinese medicine composition extract liquid being used for the treatment of periodontitis and distilled water.
2. toothpaste as claimed in claim 1, it is characterized in that: the weight of each raw material is respectively the distilled water of glycerol 15g ~ 20g, carboxymethyl cellulose 1g ~ 1.5g, glucide 1g ~ 1.5g, carbamide 2g ~ 4g, calcium carbonate 30g ~ 35g, sodium lauryl sulphate 1g ~ 3g, essence 1g ~ 1.5g, traditional Chinese medicine composition extract liquid 15g ~ 20g and surplus, the quality sum of each raw material is 100g.
3. toothpaste as claimed in claim 1 or 2, is characterized in that: the crude drug of described traditional Chinese medicine composition extract liquid comprises Radix Adenophorae, Folium Isatidis, Rhizoma Panacis Majoris, Semen Myristicae, Fructus Gardeniae, Rhizoma Coptidis, Fructus Corni, Rhizoma Dioscoreae, Semen Euryales, Caulis Sargentodoxae, Galla Chinensis, Radix Scrophulariae, Rhizoma Drynariae, Radix et Rhizoma Rhei Franzenbachii, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Radix Caesalpiniae Radicis, Herba Pyrolae, the Rhizoma Anemarrhenae, Chinese enkianthus, Fructus Broussonetiae, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) and Herba Fimbristylis dichotomae.
4. the toothpaste as described in claims 1 to 3, it is characterized in that: in described traditional Chinese medicine composition extract liquid, the weight of each crude drug is respectively Radix Adenophorae 30g ~ 40g, Folium Isatidis 55g ~ 65g, Rhizoma Panacis Majoris 35g ~ 45g, Semen Myristicae 30g ~ 40g, Fructus Gardeniae 25g ~ 35g, Rhizoma Coptidis 30g ~ 40g, Fructus Corni 35g ~ 45g, Rhizoma Dioscoreae 20g ~ 30g, Semen Euryales 20g ~ 30g, Caulis Sargentodoxae 25g ~ 35g, Galla Chinensis 30g ~ 40g, Radix Scrophulariae 20g ~ 30g, Rhizoma Drynariae 40g ~ 50g, Radix et Rhizoma Rhei Franzenbachii 15g ~ 25g, Herba Rabdosiae glaucocalycis 15g ~ 25g, Herba Asteris Ageratoidis 10g ~ 20g, Radix Caesalpiniae Radicis 10g ~ 20g, Herba Pyrolae 20g ~ 30g, Rhizoma Anemarrhenae 25g ~ 35g, Chinese enkianthus 10g ~ 20g, Fructus Broussonetiae 20g ~ 30g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 25g ~ 35g and Herba Fimbristylis dichotomae 20g ~ 30g.
5. the toothpaste as described in Claims 1-4, it is characterized in that: in described traditional Chinese medicine composition extract liquid, the weight of each crude drug is respectively Radix Adenophorae 35g ~ 40g, Folium Isatidis 60g ~ 65g, Rhizoma Panacis Majoris 40g ~ 45g, Semen Myristicae 35g ~ 40g, Fructus Gardeniae 30g ~ 35g, Rhizoma Coptidis 35g ~ 40g, Fructus Corni 40g ~ 45g, Rhizoma Dioscoreae 25g ~ 30g, Semen Euryales 25g ~ 30g, Caulis Sargentodoxae 30g ~ 35g, Galla Chinensis 35g ~ 40g, Radix Scrophulariae 25g ~ 30g, Rhizoma Drynariae 45g ~ 50g, Radix et Rhizoma Rhei Franzenbachii 15g ~ 20g, Herba Rabdosiae glaucocalycis 15g ~ 20g, Herba Asteris Ageratoidis 10g ~ 15g, Radix Caesalpiniae Radicis 10g ~ 15g, Herba Pyrolae 20g ~ 25g, Rhizoma Anemarrhenae 25g ~ 30g, Chinese enkianthus 10g ~ 15g, Fructus Broussonetiae 20g ~ 25g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 25g ~ 30g and Herba Fimbristylis dichotomae 20g ~ 25g.
6. the toothpaste as described in claim 1 to 5, is characterized in that: in described traditional Chinese medicine composition extract liquid, the weight of each crude drug is respectively Radix Adenophorae 35g, Folium Isatidis 60g, Rhizoma Panacis Majoris 40g, Semen Myristicae 35g, Fructus Gardeniae 30g, Rhizoma Coptidis 35g, Fructus Corni 40g, Rhizoma Dioscoreae 25g, Semen Euryales 25g, Caulis Sargentodoxae 30g, Galla Chinensis 35g, Radix Scrophulariae 25g, Rhizoma Drynariae 45g, Radix et Rhizoma Rhei Franzenbachii 20g, Herba Rabdosiae glaucocalycis 20g, Herba Asteris Ageratoidis 15g, Radix Caesalpiniae Radicis 15g, Herba Pyrolae 25g, Rhizoma Anemarrhenae 30g, Chinese enkianthus 15g, Fructus Broussonetiae 25g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 30g and Herba Fimbristylis dichotomae 25g.
7. the preparation method of toothpaste described in claim 1 to 6, is characterized in that, comprising:
The first step, prepares described traditional Chinese medicine composition extract liquid;
Second step, glycerol, carboxymethyl cellulose, sodium lauryl sulphate and water are mixed by weight ratio, boil in a kettle., temperature is 80 DEG C ~ 100 DEG C, is cooked into jelly, slightly treats coldly use;
3rd step, the traditional Chinese medicine composition extract liquid first step prepared and all the other components are put in reactor one by one, stir 2 ~ 3h, make the abundant mix homogeneously of various material, then lower the temperature gradually;
4th step, is cooled to 40 DEG C ~ 50 DEG C by material, Chan is thin, is cooled to 35 DEG C ~ 40 DEG C, and sealing is preserved, and obtains toothpaste.
8. the preparation method of toothpaste as claimed in claim 7, is characterized in that:
The described first step is specially further,
A walks, get Radix Adenophorae, Folium Isatidis, Rhizoma Panacis Majoris, Rhizoma Coptidis, Fructus Corni, Rhizoma Dioscoreae, Galla Chinensis, Radix Scrophulariae, Rhizoma Drynariae, Radix et Rhizoma Rhei Franzenbachii, Herba Pyrolae and Chinese enkianthus, mix by described weight, be ground into 100 object powder, be 35 ~ 45MPa at pressure, temperature is under 45 ~ 55 DEG C of conditions, adopts supercritical CO 2extract 1.5 ~ 2.5 hours, collect extract, extract adds determining alcohol 70 ~ 80% ethanol, is heated to 50 ~ 70 DEG C, constantly stirs, dissolve rear filtered while hot, reject float and insoluble matter, filtrate lets cool, and separates out precipitation, filter, concentrating under reduced pressure, dry, pulverize into 200 object powder;
B walks, by remaining components by described weight mixing, obtain mixture, be ground into 100 object powder, be placed in the container of sealing, add the water relative to 2 ~ 4 times, mixture, heat 5 hours under the water-bath of 50 DEG C, filter, collect filtrate, the powder that a step obtains is joined in this filtrate, concentrating under reduced pressure, obtain the extracting solution of 0.5g/ml.
CN201510972235.1A 2015-12-22 2015-12-22 Toothpaste for treating periodontitis Pending CN105496924A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106727152A (en) * 2017-01-11 2017-05-31 安徽科技学院 A kind of common rabdosia leaf health-care toothpaste and its production method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106727152A (en) * 2017-01-11 2017-05-31 安徽科技学院 A kind of common rabdosia leaf health-care toothpaste and its production method

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