CN106146517B - 一种枸橼酸托法替尼的合成方法 - Google Patents
一种枸橼酸托法替尼的合成方法 Download PDFInfo
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- CN106146517B CN106146517B CN201610443155.1A CN201610443155A CN106146517B CN 106146517 B CN106146517 B CN 106146517B CN 201610443155 A CN201610443155 A CN 201610443155A CN 106146517 B CN106146517 B CN 106146517B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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CN201610443155.1A CN106146517B (zh) | 2016-06-20 | 2016-06-20 | 一种枸橼酸托法替尼的合成方法 |
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CN106146517A CN106146517A (zh) | 2016-11-23 |
CN106146517B true CN106146517B (zh) | 2018-08-28 |
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Families Citing this family (6)
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CN107793418B (zh) * | 2017-10-24 | 2020-08-04 | 扬子江药业集团有限公司 | 一种枸橼酸托法替布的工业化生产方法 |
CN108640921B (zh) * | 2018-04-03 | 2022-07-08 | 科兴生物制药股份有限公司 | 一种枸橼酸托法替布的制备方法 |
CN109776547A (zh) * | 2019-03-22 | 2019-05-21 | 北京新领先医药科技发展有限公司 | 一种枸橼酸托法替布的制备方法 |
CN110343113B (zh) * | 2019-08-07 | 2020-11-27 | 山东鲁抗医药股份有限公司 | 一种托法替布中间体的制备方法 |
CN112094274A (zh) * | 2020-09-08 | 2020-12-18 | 杭州华东医药集团新药研究院有限公司 | 一种改进的托法替布合成方法及杂质制备方法 |
CN115236261B (zh) * | 2022-05-10 | 2024-04-19 | 武汉海特生物创新医药研究有限公司 | 一种托法替尼中间体纯度的hplc-uv检测方法 |
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PT1913000E (pt) * | 2005-07-29 | 2012-02-28 | Pfizer Prod Inc | Derivados de pirrolo[2,3-d]pirimidina, suas substâncias intermédias e processo de síntese |
WO2008029237A2 (en) * | 2006-09-05 | 2008-03-13 | Pfizer Products Inc. | Combination therapies for rheumatoid arthritis |
CN101560180A (zh) * | 2009-05-15 | 2009-10-21 | 上海清松制药有限公司 | 4-卤代异吲哚啉盐酸盐的制备方法 |
CN103524487B (zh) * | 2013-09-29 | 2015-12-02 | 南京优科生物医药研究有限公司 | 一种西他沙星的制备方法 |
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Effective date of registration: 20191218 Address after: No.156 Laixun Road, Danxi street, Xiangshan County, Ningbo City, Zhejiang Province 315700 Patentee after: Ningbo Yihe Medical Technology Co., Ltd. Address before: 250061 No. 44 West Wenhua Road, Lixia District, Shandong, Ji'nan Patentee before: Shandong University |
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Effective date of registration: 20200327 Address after: 318000 Binhai Road, Jiaojiang District, Zhejiang, China, No. 29, No. Patentee after: ZHEJIANG LEPU PHARMACEUTICAL Co.,Ltd. Address before: No.156 Laixun Road, Danxi street, Xiangshan County, Ningbo City, Zhejiang Province 315700 Patentee before: NINGBO YIHE HI-TECH Co.,Ltd. |