CN106039205A

CN106039205A - Traditional Chinese medicine granules for treating reflux esophagitis and preparation method thereof

Info

Publication number: CN106039205A
Application number: CN201610411574.7A
Authority: CN
Inventors: 侯小霞; 吴美英; 任直亲
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-06-14
Filing date: 2016-06-14
Publication date: 2016-10-26

Abstract

The invention discloses traditional Chinese medicine granules for treating reflux esophagitis and a preparation method thereof and belongs to the field of traditional Chinese medicine. The granules of the invention are made from the effective materials: rice straw, Trigonotis peduncularis herb, longstamen onion bulb, Radix Fici Beecheyanae, Radix Adenophorae, Herba Desmodii Styracifolii, polished round-grained rice, Radix Ophiopogonis, Radix Astragali, medicated leaven, licorice root, Herba Limnophilae Rugosae, Fructus Ponciri Trifoliatae, Folium Raphani, Rhizoma Cyperi, Emmenopterys henryi root, Fructus Citri Sarcodactylis, Concha Arcae, Radix Curcumae, Fructus Viticis Negundo, Fructus Amomi, Pericarpium Arecae, citrus peel and Fructus Evodiae. The medicinal materials used herein meet the principle of monarch, minister, assistant and guide, the remedy is suited to causes of disease, the granules have the effects of tonifying middle warmer and benefiting qi, reinforcing spleen and inducing diuresis, benefiting stomach and promoting secretion of bodily fluid, soothing liver and regulating qi, descending qi and relieving the middle warmer, harmonizing stomach and removing phlegm, promoting digestion to remove stagnation, lowering the adverse qi to stop vomit and relieving hyperacidity to stop pain, are good in absorption effect and significant in therapeutic effect, are free of toxic and side effects and clinical adverse reaction, and are clinically proved to have a high cure rate for reflux esophagitis.

Description

A kind of instant particles as Chinese medicine for treating Reflux exophagitis and preparation method

Art

The present invention relates to the field of Chinese medicines, particularly relate to a kind of instant particles as Chinese medicine for treating Reflux exophagitis and preparation side Method.

Background technology

Reflux exophagitis is because gastric content reflux to be caused to esophagus, is commonly called as " heartburn disease ", because under normal circumstances Gastric acid exists only in stomach, when reflux people's esophagus calcination or stimulate esophagus and produce " heartburn sense ".It occur frequently that in after meal, because of Cause higher than esophagus for esophageal sphincter tension reduction or intragastric pressure.Gastric content prolonged and repeated stimulation Esophageal Mucosa, especially It is distal esophagus mucosa and causes inflammation, this disease often with the disease such as chronic gastritis, peptic ulcer or Hernia hiatus depositing, But also can individualism.Cardinal symptom is to burn sense of discomfort or causalgia after acid regurgitation, acid regurgitation, breastbone, and dysphagia etc..

Western medical treatment primary disease is mainly from promoting that esophagogastric emptying and suppression neutralize gastric acid and start with symptomatic treatment, as can With in antacid and gastric acid, reduce pepsic activity.Gastric emptying is extended available gastric motility medicine such as domperidone etc., clothes Although by these medicine quick results, but treatment cycle is long, it is impossible to radical cure, the easy recurrent exerbation of the state of an illness, and these medicines of long-term taking Thing can produce some side effect.

Reflux exophagitis according to clinical manifestation can belong to the traditional Chinese medical science " acid regurgitation ", " acid regurgitation ", " regurgitation ", " noisy ", " dysphagic ", The category such as " stomach painful abdominal mass ", " thoracic obstruction ", in Chinese medicine, the liver belonging to wood, main catharsis, hair growth promoting yang-energy, bar reaches feelings will.The stomach pertaining to earth, master is received, To lead to as use.On esophagus and throat, lower even gastral cavity abdomen, belong to stomach and led, stomach is reservoir of food and drink, and spleen the exterior and the interior each other, and department is received fortune altogether Changing and defeated cloth function, and transporting and transforming function of the spleen and stomach is relevant to the catharsis function of liver, therefore primary disease disease position is at esophagus, close with liver, stomach, spleen relation Cut.Therefore the primary disease cause of disease is unsuccessful mainly due to feelings will, eating and drinking without temperance, work and rest is excessive, causes the liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation, occurs Stomach-QI being unable to descend normally, superinverse is in esophagus, and esophagus loses in moistening foster, and logical fall is unfavorable and falls ill.The present invention suits the remedy to the case according to the cause of disease, has benefit Middle QI invigorating, invigorating spleen to remove dampness, reinforcing stomach reg fluid, liver-smoothing, qi-regulating, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, stomach function regulating reduce phlegm, promoting digestion and removing stagnation, stopping nausea and vomiting by lowering the adverse flow of QI, antacid only Effect of pain, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, according to clinical verification to reflux esophagus Scorching cure rate is higher.

Summary of the invention

The invention provides a kind of instant particles as Chinese medicine for treating Reflux exophagitis and preparation method, there is invigorating middle warmer benefit Gas, invigorating spleen to remove dampness, reinforcing stomach reg fluid, liver-smoothing, qi-regulating, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, stomach function regulating reduce phlegm, promoting digestion and removing stagnation, stopping nausea and vomiting by lowering the adverse flow of QI, relieving gastric hyperacidity to alleviate stomachache it Effect, cures the disease and seeks source treating both the principal and secondary aspects of a disease, and the Reflux exophagitis causing a variety of causes is respectively provided with good curative effect.

For achieving the above object, technical scheme is implemented as follows:

A kind of instant particles as Chinese medicine for treating Reflux exophagitis, makes raw material composition and the weight of described effective ingredient Amount number is:

Caulis et Folium Oryzae 65～80 parts, Herba Trigonotidis peduncularis 62～77 parts, Chinese onion root 59～74 parts, Radix Fici beecheyanae 56～70 parts,

Radix Adenophorae (Radix Glehniae) 53～66 parts, Herba Lysimachiae 50～63 parts, Semen oryzae sativae 47～60 parts, Radix Ophiopogonis 44～56 parts,

The Radix Astragali 41～53 parts, Massa Medicata Fermentata 39～50 parts, Radix Glycyrrhizae 36～46 parts, Herba Limnophilae rugosae 33～43 parts,

Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 30～40 parts, Folium Raphani 26～37 parts, Rhizoma Cyperi 23～34 parts, Emmenopterys henryi oliv. 20～31 parts,

Fructus Citri Sarcodactylis 17～28 parts, Concha Arcae 15～25 parts, Radix Curcumae 12～22 parts, Fructus Viticis Negundo 10～19 parts,

Fructus Amomi 7～16 parts, Pericarpium Arecae 5～13 parts, Pericarpium Citri 3～10 parts, Fructus Evodiae 1～8 parts.

Make described effective ingredient raw material composition and parts by weight be:

Caulis et Folium Oryzae 68～77 parts, Herba Trigonotidis peduncularis 65～74 parts, Chinese onion root 62～70 parts, Radix Fici beecheyanae 59～67 parts,

Radix Adenophorae (Radix Glehniae) 56～63 parts, Herba Lysimachiae 53～60 parts, Semen oryzae sativae 50～57 parts, Radix Ophiopogonis 47～59 parts,

The Radix Astragali 44～50 parts, Massa Medicata Fermentata 42～47 parts, Radix Glycyrrhizae 39～43 parts, Herba Limnophilae rugosae 36～40 parts,

Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 33～37 parts, Folium Raphani 29～34 parts, Rhizoma Cyperi 26～31 parts, Emmenopterys henryi oliv. 23～28 parts,

Fructus Citri Sarcodactylis 20～25 parts, Concha Arcae 18～22 parts, Radix Curcumae 15～19 parts, Fructus Viticis Negundo 12～16 parts,

Fructus Amomi 9～14 parts, Pericarpium Arecae 7～10 parts, Pericarpium Citri 5～8 parts, Fructus Evodiae 2～5 parts.

Caulis et Folium Oryzae 73 parts, Herba Trigonotidis peduncularis 70 parts, Chinese onion root 66 parts, Radix Fici beecheyanae 63 parts,

Radix Adenophorae (Radix Glehniae) 60 parts, Herba Lysimachiae 57 parts, Semen oryzae sativae 54 parts, Radix Ophiopogonis 51 parts,

The Radix Astragali 47 parts, Massa Medicata Fermentata 44 parts, 41 parts of Radix Glycyrrhizae, Herba Limnophilae rugosae 38 parts,

Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 35 parts, Folium Raphani 32 parts, Rhizoma Cyperi 29 parts, Emmenopterys henryi oliv. 26 parts,

Fructus Citri Sarcodactylis 23 parts, Concha Arcae 20 parts, Radix Curcumae 17 parts, Fructus Viticis Negundo 14 parts,

Fructus Amomi 12 parts, Pericarpium Arecae 9 parts, Pericarpium Citri 6 parts, Fructus Evodiae 3 parts.

The preparation method of a kind of instant particles as Chinese medicine for treating Reflux exophagitis, comprises the following steps that:

(1) by Caulis et Folium Oryzae, Herba Trigonotidis peduncularis, Chinese onion root, Radix Fici beecheyanae, Radix Adenophorae (Radix Glehniae), Herba Lysimachiae, Semen oryzae sativae, Radix Ophiopogonis, Herba Limnophilae rugosae, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Lay Fu leaf, Emmenopterys henryi oliv., Fructus Citri Sarcodactylis, Fructus Viticis Negundo, Pericarpium Arecae, Pericarpium Citri, Fructus Evodiae are cleaned, are dried rear mix homogeneously, put in container, Container adds the water of 6～8 times amount, heated and boiled 2～3 hours, after cooling, takes immersion；4～6 are added in remaining medicinal residues The water of times amount, heated and boiled 1～2 hours, take immersion after cooling；Merging twice gained immersion, heating, evaporation and concentration is the closeest The thick paste of degree 1.15～1.25, standby；

(2) astragalus mongholicus tablet is added cooked Mel and a little boiled water, mixes thoroughly the most vexed, fry in putting pot to yellow and tack-free time, Taking-up is dried in the air cool, and pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(3) taking Massa Medicata Fermentata, be cut into small pieces, fry sallow to surface with slow fire, take out, cool, pulverizing is ground into powder, crosses 100 mesh thin Sieve, obtains fine powder, standby；

(4) take clean Radix Glycyrrhizae tabellae, add cooked Mel and a little boiled water, the most vexed after mixing thoroughly, to put in parch container, slow fire is fried To buff, taking out, cool time tack-free, pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(5) take Rhizoma Cyperi and clean section, add quantitative rice vinegar and mix thoroughly, after moistening is sucked to vinegar, put in parch container, with literary composition Fire heating fried dry, taking-up is dried in the air cool, and sieve goes chip, pulverizing to grind into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(6) taking clean Concha Arcae and put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and pulverizing is ground into powder, Cross 100 mesh dusting covers, obtain fine powder, standby；

(7) Radix Curcumae sheet is mixed thoroughly with rice vinegar, vexed, puts the interior slow fire of pot and heats fried dry, and taking-up cools, and sieve removes chip, pulverizes Grind into powder, cross 100 mesh dusting covers, obtain fine powder, standby；

(8) taking clean Fructus Amomi, mix thoroughly with saline soak, slow fire is fried to micro-dry, and taking-up cools, and pulverizing is ground into powder, crosses 100 mesh thin Sieve, obtains fine powder, standby；

(9) by the thick paste of step (1) gained, with step (2), step (3), step (4), step (5), step (6), step (7), the fine powder mixing of gained in step (8), add adjuvant sucrose and dextrin mix homogeneously make granule, be dried, after granulate, encapsulation Become the instant particles as Chinese medicine of every bag of 10g.

The property of medicine of Chinese medicine used by the present invention is as follows:

Caulis et Folium Oryzae: acrid in the mouth；Warm in nature.Return spleen；Lung meridian.Alleviating distention in middle-JIAO；The therapeutic method to keep the adverse QI flowing downwards；Help digestion；Removing toxic substances.Cure mainly dysphagic；Regurgitation；Dyspepsia；Stomachache； Have loose bowels；Quench one's thirst；Jaundice；Sore throat；Hemorrhoid；Burn and scald.

Herba Trigonotidis peduncularis: acrid in the mouth, bitter；Property flat.GUIXIN；Liver；Spleen；Kidney channel.Promoting the circulation of QI to relieve pain；Removing toxic substances and promoting subsidence of swelling.Cure mainly stomachache acid regurgitation；Dysentery Disease；Pyretic toxicity carbuncle；Numbness of hands and feet.

Chinese onion root: acrid in the mouth；Bitter；Warm in nature.Return lung；The heart；Stomach；Large intestine channel.Regulate the flow of vital energy the chest stuffiness relieving；Activating YANG and eliminating stagnation.Cure mainly obstruction of qi in the chest and cardialgia thorough The back of the body；Breast gastral cavity painful abdominal mass is vexed；Cough with asthma abundant expectoration；Epigastric pain；Let out weight after dysentery；Leucorrhea；Furuncle carbuncle." detailed outline ": control SHAO YIN syndrome and faint against letting out dysentery, And thoracic obstruction twinge, the therapeutic method to keep the adverse QI flowing downwards dissipates blood, antiabortive.Temperature compensation is supporing yang road.Modern medicine study proves: Chinese onion root have antibacterial, antihypertensive diuretic and Antitumaous effect, and there is expansion blood vessel, antiplatelet aggregation, prevent thrombosis, reduce the effect of blood fat.

Radix Fici beecheyanae: sweet in the mouth；Pungent；Warm in nature.Return lung；Spleen；Kidney channel.Replenishing QI to invigorate the spleen；Promoting blood circulation to remove obstruction in the collateral；Expelling wind and removing dampness.Cure mainly labor Tired weak；Lack of appetite；Agalactia；Insufficiency of the spleen leucorrhea；Proctoptosis；Menoxenia；Wind syndrome of head pain；Traumatic injury；Rheumatic arthralgia. " east, Fujian book on Chinese herbal medicine ": invigorating the spleen and replenishing QI, invigorating the spleen for eliminating dampness, bone and muscle strengthening, detumescence, promoting blood circulation and detoxication.Controlling the middle deficiency of vital energy weak, QI and blood is on the decline, extremity Aching and limp, stiffness of the muscle and joint, amenorrhea, galactostasis.

Radix Adenophorae (Radix Glehniae): sweet in the mouth；Micro-hardship；Cold nature.Return lung；Stomach warp.Replenishing YIN and removing heat；Moistening the lung and resolving phlegm；Reinforcing stomach reg fluid.Cure mainly the deficiency of YIN long Cough；Consumptive disease is coughed expectorant blood；Cough caused by dryness expectorant is few；Deficiency-heat sore throat；Tianjin wound is thirsty.Compendium of Material Medica carries: " Radix Adenophorae (Radix Glehniae) is sweet light and cold, and its body is the most empty, specially Tonifying the lung gas, thus strengthening the spleen and kidney, thus gold can by fire gram person suitable it.YANG invigorating and raw the moon, nourishing YIN and sun processed, must debate also." existing Confirming for medical research, Radix Adenophorae (Radix Glehniae) contains volatile oil, coumarin, starch, alkaloid, triterpenic acid, stigmasterol, β-each sterol, improves T Cell ratio, improves lymhocyte transformation rate, leukocyte increasing, strengthens macrophage function, extends antibody and there is the time, has solution Heat, ease pain, eliminate the phlegm, function of relievining asthma, strengthen body fluid and the immunologic function of cell, protected to irritability and Drug gastric ulcer and Inhibitory action.

Herba Lysimachiae: sweet in the mouth；Micro-hardship；Cool in nature.Enter liver；Gallbladder；Kidney；Bladder warp.Relieving stranguria by diuresis；Heat-clearing and toxic substances removing；Dissipating blood stasis for subsidence of swelling.Main Treating the liver gallbladder and urinary system calculus；Pyretic stranguria；Oedema due to nephritis；Jaundice due to damp-heat；Sore carbuncle；Venom；Traumatic injury.Modern medicine Research confirms, Herba Lysimachiae mainly containing phenolic constituent and sterol, flavonoid, tannin, volatile oil, choline, potassium salt etc., have calculus, Antibacterial, treating stranguria, antiinflammatory action, all has obvious inhibitory action to humoral immunization, cellular immunization.

Semen oryzae sativae: sweet in the mouth；Property flat.Return spleen；Stomach；Lung meridian.Invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, relieving thirst and restlessness, antidiarrheal dysentery.Cure mainly taste The deficiency of vital energy；Lack of appetite is indigestion and loss of appetite；Fatigue and weakness；Restlessness and thirst；Rush down lower dysentery." the southern regions of the Yunnan Province book on Chinese herbal medicine ": control weakness, reinforcing YIN-essence bone strengthening, promote the production of body fluid, Improving eyesight, long intelligence.

Radix Ophiopogonis: sweet in the mouth；Micro-hardship；Cold in nature.Return lung；Stomach；Heart channel.Nourishing YIN and moistening the lung；Reinforcing stomach reg fluid；Clear away heart-fire relieving restlessness.Cure mainly lung Dry dry cough；Lung abscess；Deficiency of YIN chronic cough；Tianjin wound is thirsty；Quench one's thirst；Vexed insomnia；Have sore throat；Dryness of the intestine constipation；Heat in blood tells nosebleed." book on Chinese herbal medicine Converge and say ": Radix Ophiopogonis, the medicine of clearing away heart-fire and moistening the lung is also.Main deficiency of heart-QI, palpitate with fear palpitation with a distress feeling, forgetful dimly, spirit fall；Or the lung-heat dryness of the lung, Coughing sound running fire, consumptive lung disease leaf scorch, dyspnea due to deficiency of losing heart, fire lies prostrate in lung, hemoptysis of spitting blood；Or asthenia exopathogenic heat, body fluid is dry few；Or taste are dry dries up, Constipation due to insufficiency dyschezia；This card that all cardiopulmonary kidney spleen unit asthenic fire is strongly fragrant is also.But sweet in the mouth gas is put down, energy lung benefiting gold, bitter in the mouth is cold in nature, can drop heart-fire, Body profit matter is mended, and can support medulla renis, and the merit specially controlling strain deficiency-heat is in the majority.Stagnation of QI in chest and abdomen as main in front Gu, damaging the spleen and stomach wound is full, and stomach channels is exhausted, thin The thin disease such as lose heart, then belong to strain bright.

The Radix Astragali: sweet in the mouth；Warm in nature.Enter the heart；Lung；Spleen；Kidney channel.Invigorating QI to consolidate the body surface resistance；Diuresis；Expelling pus and toxin by strengthening QI；Promoting tissue regeneration and ulcer healing.Cure mainly gas Short cardiopalmus；Asthenia；Weak；Spontaneous perspiration；Night sweat；Chronic diarrhea；Proctoptosis；Body is impractical swollen；Uterine prolapse；Chronic nephritis；Carbuncle difficulty is burst；Or burst Do not hold back for a long time." Xinhua's book on Chinese herbal medicine outline " carries: " have the function of invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, granulation promoting." modern medicine study confirmation, yellow Stilbene is mainly composed of Radix Astragali total flavones, Radix Astragali Mongolici total polysaccharide, Radix Astragali total saponins and aminoacid etc., have diuretic antihypertensive, anti-inflammatory analgesic, Heart tonifying, antioxidant radical generate and improve the multiple pharmacological effect such as body's immunity, can act on body from many aspects, improve The relevant blood vessel sexually transmitted disease (STD)s such as cardiovascular, cerebrovascular, diabetes, nephropathy become the merits such as hemodynamics and the vascular endothelial cell of patient Energy.

Massa Medicata Fermentata: sweet in the mouth；Pungent；Warm in nature；Nontoxic.Enter spleen；Stomach warp.Invigorating the spleen and regulating the stomach；Promoting digestion and removing stagnation；Cure mainly retention of food and drink；Disappear Change bad；Distension and fullness in the abdomen；Inappetence；Vomiting dysentery." book on Chinese herbal medicine is just " carries: " sweet in the mouth gas is put down, and parching to brown is used as medicine, and is apt to help middle scorched earth dirty, Spleen invigorating warming the stomach, removing stagnancy of indigested food and making QI downward, change in stagnant tune, by accumulation of phlegm, broken abdominal mass, transporting and transforming nutrients from foodstuff, except cholera distension is vomitted.Its gas is rotten, therefore energy Dehumidifying heat, its property is puckery, therefore antidiarrheal dysentery again.Treatment woman's fetal movement, because of stagnant, controls children's's abdomen heavily fortified point because of long-pending." modern medicine study confirmation, six god Bent containing volume yeast and vitamin B group, energy appetite stimulator, maintain normal stool function, Ore class medicine can also be helped simultaneously Digest and assimilate.

Radix Glycyrrhizae: sweet in the mouth；Property flat.GUIXIN；Lung；Spleen；Stomach warp.Invigorating the spleen and replenishing QI；Heat-clearing and toxic substances removing；Expelling phlegm for arresting cough；Relieving spasm to stop pain；Adjust With all medicines.Cure mainly weakness of the spleen and stomach；Fatigue and weakness；Shortness of breath and palpitation；Cough with copious phlegm；Gastral cavity abdomen extremity contraction urgency pain；Carbuncle sore tumefacting virus；Alleviate Drug toxicity.Compendium of Material Medica carries: " in all medicines, Radix Glycyrrhizae is monarch.Control 72 kinds of mammary calculus poison, solution 1,002 poison of draft by every means, adjust Gain merit with from medicine." modern medicine study confirms, Radix Glycyrrhizae has a stronger Detoxication, also antiulcer, anti-inflammatory, spasmolytic antitussive, Lowering blood pressure and blood fat, antitumaous effect, be widely used in treatment pharyngolaryngitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis Etc. disease, additionally there is anti-gastric-ulcer, gastritis effect.

Herba Limnophilae rugosae: acrid in the mouth；Sweet；Warm in nature.Return lung；Spleen；Stomach warp.Invigorating spleen to remove dampness；Activating QI to eliminate phlegm.Cure mainly edema；Stomachache；Chest and abdomen Distension；Cough；Children's's infantile dyspepsia；Furuncle." Nanning City's medicine will ": " dampness removes expectorant, reducing swelling and alleviating pain, and parasite killing detoxifies.Control asthma to cough Cough, children's's milk abdominal mass, furuncle, snakebite, cold syndrome of the stomach pain."

Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus): acrid in the mouth；Bitter；Warm in nature.Return liver；Stomach warp.Dispersing the stagnated liver-QI for regulating the stomach；Regulating QI to relieve pain；Removing food stagnancyization is stagnant.Cure mainly fullness and distention in the chest and hypochondrium； Abdominal distention；Breast lumps；Hernia pain；Painful and swollen testis；Traumatic injury；Food stagnation；Constipation；Uterine prolapse." medium-height grass is commonly used in Shanghai Medicine ": promoting the circulation of QI, stomach invigorating, relieving constipation.Control stomach distension, dyspepsia, constipation, uterine prolapse, tuberculosis of breast.

Folium Raphani: acrid in the mouth；Bitter；Property flat.Return spleen；Stomach；Lung meridian.Help digestion and regulate the flow of vital energy；Removing heat from the lung and relieving sorethroat；Dissipating blood stasis for subsidence of swelling.Cure mainly food stagnation The stagnation of QI；Gastral cavity abdomen feeling of fullness；Singultus；Acid regurgitation；Have loose bowels；Dysentery；Cough what is said or talked about；Hoarseness；Laryngopharynx swelling and pain；Female breast swells and ache；Galactostasis；Outward Control damage congestive edema." the southern regions of the Yunnan Province book on Chinese herbal medicine ": white turnip bar leaf, controls incoordination between the spleen and stomach, and dyspepsia does not disappears, and chest and diaphragm expands, dysphagic, hiccough, vomiting acid Water, dysentery, married woman's breast knot, swelling of the breast, amenorrhea.

Rhizoma Cyperi: acrid in the mouth；It is slightly cold；Nontoxic.Return liver；Lung；Spleen；Stomach；Tri-jiao channel.Regulate the flow of vital energy resolving depression；Menstruction regulating and pain relieving；Antiabortive.Cure mainly Distending pain over the hypochondrium；Mammary swelling is educated；Hernia pain；Menoxenia；Gastral cavity abdomen feeling of fullness pain；Belch acid regurgitation, vomiting and nausea；Abdominal pain during menstruation；Metrorrhagia Leukorrhagia；Frequent fetal movement." detailed outline " dissipates seasonal epidemic pathogens and trembles with fear epidemic disease, and profit three is burnt, Xie Nvyu, and the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, foot Gas, only trusted subordinate, limbs, head, mesh, tooth, all pains of ear, ulcer sores, spit blood, hematochezia, hematuria, married woman's bleeding not during menses, menoxenia, All kinds of diseases and ailments in puerperal before tire.

Emmenopterys henryi oliv.: acrid in the mouth；Sweet；Slightly warm in nature.Return stomach warp.Wet middle stomach function regulating；Stopping nausea and vomiting by lowering the adverse flow of QI.Cure mainly regurgitation；Vomiting；Singultus.

Fructus Citri Sarcodactylis: acrid in the mouth；Bitter；Warm in nature.Enter liver；Stomach；Spleen；Lung meridian.Liver-smoothing, qi-regulating；Stomach function regulating reduces phlegm.Cure mainly the side of body of depression of liver-QI Bitterly；Uncomfortable in chest；Incoordination between the liver and stomach；The abdominal distention of stagnation of QI in spleen and stomach；Gas；Feel sick；Chronic cough abundant expectoration." book on Chinese herbal medicine is the newest " carries: " control gas to relax Liver, stomach function regulating reduces phlegm, removing mass, controls dysphagia and regurgitation, eliminating mass abdominal mass scrofula." modern medicine study confirmation, Fructus Citri Sarcodactylis has phlegm-dispelling functions of relievining asthma, Antagonism airway constriction, the tension force alleviating rapidly stomach, intestinal and gallbladder increases, and extends convulsions time of origin, prevents arrhythmia, strengthens The resistance of hair and blood pipe, and there is the effect of antiinflammatory.

Concha Arcae: sweet in the mouth；Salty；Property flat.Enter liver；Spleen；Stomach warp.Expectorant blood stasis dispelling；Hard masses softening and resolving；Relieving gastric hyperacidity to alleviate stomachache.Cure mainly scrofula； Abdominal mass mass in the abdomen；Pertinacious phlegm chronic cough；Stomachache acid regurgitation；Ulcerative gingivitis；Traumatic hemorrhage；Chilblain and burn and scald." detailed outline " carries: " salty flavor acting on blood and softening the hard mass, Therefore the clot that can disappear, dissipate accumulation of phlegm." modern medicine study confirmation, Concha Arcae is used for controlling QI and blood abdominal mass has obvious curative effect, rich in a large number Calcium carbonate, a small amount of magnesium, ferrum, silicate, sulfate and chloride and organic matter, nucleic manganese is had special accumulation ability, clinical On be mainly used in reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling.

Radix Curcumae: acrid in the mouth；Bitter；Cold in nature.Enter the heart；Liver；Gallbladder meridian.Invigorate blood circulation relieving convulsion；Promoting QI circulation for relieving depression；Clear away heart-fire removing heat from blood；Depressed liver-energy dispersing and function of gallbladder promoting.Main Control the chest and abdomen side of body all pains of rib；Dysmenorrhes；Amenorrhea；Abdominal mass is lumpd；Calentura coma；Demented；Infantile convulsion；Spit blood；Epistaxis；Stranguria with blood；Sand Stranguria； Jaundice.Essentials of Matea Medica carries: " circulation of qi promoting, resolving depression；Let out blood, removing blood stasis with potent drugs.Cool heat in the heart, dissipates stagnation of liver-QI, can open the strongly fragrant of lung gold." modern medicine grinds Studying carefully confirmation, Radix Curcumae, rich in Radix Curcumae polysaccharide, has enhancing reticuloendothelial system activity, ethanol extract obvious shadow original to fibrin Ring, T-CHOL and content of triglyceride in aorta can be reduced.

Fructus Viticis Negundo: acrid in the mouth；Bitter；Warm in nature.Return lung；Stomach；Liver Channel.Expelling pathogenic wind from the body surface；Relieving cough and asthma；Regulate the flow of vital energy the pain relieving that helps digestion.Cure mainly Common Cold；Cough；Asthma；Stomachache acid regurgitation；Dyspepsia；Food stagnation dysentery；Cholecystitis；Cholelithiasis；Hernia." Guangzhou flora " Carry: " Fructus Viticis Negundo dispels the wind, clearing away phlegm, antitussive." modern medicine study confirmation, bronchial smooth muscle is had expansion to make by Fructus Viticis Negundo decoct With, trachea-bronchial epithelial cell spasm can be released.“

Fructus Amomi: acrid in the mouth；Warm in nature.Enter spleen；Stomach；Kidney channel.Removing dampness is whetted the appetite；Promoting the circulation of QI to alleviate the stagnation in middle-JIAO；Warming the spleen；Antidiarrheal；Antiabortive.Cure mainly dampness The stagnation of QI；Abdominal distention；Anorexia；Nausea and vomiting；Stomachache is had loose bowels；Pregnancy reactions；Frequent fetal movement." detailed outline " carries: " tonifying the lung is waken up Spleen, nourishing the stomach kidney tonifying, manage vigour, dispelling stagnant Qi, dispelling cold fluid-retention and abdominal distension, dysphagic vomiting, only woman's metrorrhagia, except throat ability to speak superficial heat, change copper Gagger is choked." modern medicine study confirmation, Fructus Amomi can be strengthened intestinal contraction, have inhibitory action to intestinal tube, show tension force time heavy dose of Reduce, partially or completely antagonism acetylcholine, promote intestinal movement, hence it is evident that suppression platelet aggregation, hence it is evident that antagonism collagen and kidney The fall out effect of upper parathyrine.

Pericarpium Arecae: acrid in the mouth；Slightly warm in nature.Enter spleen；Stomach；Large intestine；Small intestine meridian.Therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO；Line water detumescence.Cure mainly chest and abdomen swollen Vexed；Edema；Tinea pedis；Dysuria." book on Chinese herbal medicine is the newest " carries: " dampness removing chases after wind, and wide intestinal is subsided a swelling, and manages waist tinea pedis, controls for eliminating the pathogens from the lung, easing stomach-QI Malaria dysentery." modern medicine study confirms, Pericarpium Arecae can improve intestinal tube tonicity, reduces shrinkage amplitude, has regulation intestinal and smooths The function of flesh.

Pericarpium Citri: acrid in the mouth；Bitter；Acid；Warm in nature.Enter liver；Lung；Spleen channel.Regulating QI and lowering the adverseness；The chest stuffiness relieving reduces phlegm.Cure mainly chest and abdomen full vexed；The side of body Rib distending pain；Cough with copious phlegm." book on Chinese herbal medicine is the newest " carries: " suppressing the hyperactive liver Shu Yu, manages lung qi, and stimulate the menstrual flow diuretic, controls waist tinea pedis." modern medicine study Confirming, volatile oil contained by Pericarpium Citri has gentle stimulation to gastrointestinal tract, can promote to wriggle and Digestive system composition in the intestines and stomach, get rid of Enteral pneumatosis, and eliminate the phlegm, antiinflammatory, antiviral, and prevention cold injury and suppression aldehyde reductase effect.

Fructus Evodiae: acrid in the mouth；Bitter；Property heat；Mild toxicity.Enter liver；Stomach；Spleen；Large intestine；Kidney channel.Dispersing cold for relieving pain；The soothing the liver therapeutic method to keep the adverse QI flowing downwards；Warming middle-JIAO Dampness.Cure mainly coldness and pain in the epigastrium；Headache due to JUE YIN disorder；Colic；Tinea pedis swells and ache；Vomiting acid regurgitation；Cold-damp is had loose bowels.Compendium of Material Medica carries: " dissipating depression of QI Changing stagnant, control acid regurgitation, cloudy sputum headache of fainting, insidious stomachache, hernia, dysentery, mouthpiece's mouth is choked." modern medicine study confirmation, Fructus Evodiae Town is had to tell, antidiarrheal, antiulcer, suppression stomach motion, heart tonifying, rise blood pressure, shock, improve microcirculation, improve immunologic function etc. and make With.

The present invention compared with prior art, has the advantages that

The present invention selects medical material monarch, minister, a left side, makes all reasons the most standby, and the property of medicine is suitable mutually auxiliary mutually, for causing Reflux exophagitis The cause of disease is suited the remedy to the case, and has invigorating the spleen and replenishing QI, invigorating spleen to remove dampness, reinforcing stomach reg fluid, liver-smoothing, qi-regulating, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, stomach function regulating to reduce phlegm, digestion-promoting Long-pending, stopping nausea and vomiting by lowering the adverse flow of QI, effect of relieving gastric hyperacidity to alleviate stomachache, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, through facing Bed checking is higher to Reflux exophagitis cure rate.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The raw material of effective ingredient of the present invention forms and weight is:

Caulis et Folium Oryzae 65～80g, Herba Trigonotidis peduncularis 62～77g, Chinese onion root 59～74g, Radix Fici beecheyanae 56～70g,

Radix Adenophorae (Radix Glehniae) 53～66g, Herba Lysimachiae 50～63g, Semen oryzae sativae 47～60g, Radix Ophiopogonis 44～56g,

The Radix Astragali 41～53g, Massa Medicata Fermentata 39～50g, Radix Glycyrrhizae 36～46g, Herba Limnophilae rugosae 33～43g,

Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 30～40g, Folium Raphani 26～37g, Rhizoma Cyperi 23～34g, Emmenopterys henryi oliv. 20～31g,

Fructus Citri Sarcodactylis 17～28g, Concha Arcae 15～25g, Radix Curcumae 12～22g, Fructus Viticis Negundo 10～19g,

Fructus Amomi 7～16g, Pericarpium Arecae 5～13g, Pericarpium Citri 3～10g, Fructus Evodiae 1～8g.

The processing step of process for preparing medicine of the present invention is:

Usage and dosage: oral, each 1 bag, every day 2 times, sub-service sooner or later, take after mixing it with water with boiled water half an hour ante cibum, within 20 days, be 1 The course for the treatment of.

Embodiment 2

Caulis et Folium Oryzae 68～77g, Herba Trigonotidis peduncularis 65～74g, Chinese onion root 62～70g, Radix Fici beecheyanae 59～67g,

Radix Adenophorae (Radix Glehniae) 56～63g, Herba Lysimachiae 53～60g, Semen oryzae sativae 50～57g, Radix Ophiopogonis 47～59g,

The Radix Astragali 44～50g, Massa Medicata Fermentata 42～47g, Radix Glycyrrhizae 39～43g, Herba Limnophilae rugosae 36～40g,

Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 33～37g, Folium Raphani 29～34g, Rhizoma Cyperi 26～31g, Emmenopterys henryi oliv. 23～28g,

Fructus Citri Sarcodactylis 20～25g, Concha Arcae 18～22g, Radix Curcumae 15～19g, Fructus Viticis Negundo 12～16g,

Fructus Amomi 9～14g, Pericarpium Arecae 7～10g, Pericarpium Citri 5～8g, Fructus Evodiae 2～5g.

The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.

Embodiment 3

Caulis et Folium Oryzae 73g, Herba Trigonotidis peduncularis 70g, Chinese onion root 66g, Radix Fici beecheyanae 63g,

Radix Adenophorae (Radix Glehniae) 60g, Herba Lysimachiae 57g, Semen oryzae sativae 54g, Radix Ophiopogonis 51g,

Radix Astragali 47g, Massa Medicata Fermentata 44g, Radix Glycyrrhizae 41g, Herba Limnophilae rugosae 38g,

Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 35g, Folium Raphani 32g, Rhizoma Cyperi 29g, Emmenopterys henryi oliv. 26g,

Fructus Citri Sarcodactylis 23g, Concha Arcae 20g, Radix Curcumae 17g, Fructus Viticis Negundo 14g,

Fructus Amomi 12g, Pericarpium Arecae 9g, Pericarpium Citri 6g, Fructus Evodiae 3g.

Clinical data:

1, case selection

Selecting the Reflux exophagitis patient 76 example clinical observation that my institute makes a definite diagnosis, patient is randomly divided into two groups.Treatment group 38 Example, wherein male 16 example, women 22 example, age 29～61 years old, 42.7 years old mean age.Matched group 38 example, wherein male 14 example, Women 24 example, age 30～60 years old, 42.1 years old mean age.Two groups of qualifications and record of service are basically identical, without significant difference, have comparability.

2, treatment group patient takes medicine of the present invention, oral, each 1 bag, every day 2 times, sub-service sooner or later, half an hour ante cibum with Boiled water is taken after mixing it with water, and within 20 days, is 1 course for the treatment of, takes 3 courses for the treatment of.Matched group, according to the patient's condition of the Reflux exophagitis being diagnosed to be, gives Western medicine routine treatment, as given Lansoprazole enteric-coated tablet 15mg, 2 times/day, oral；Gel aluminum hydroxide 10ml, 3 times/day, mouth Clothes；Cisapride sheet 10mg, 3 times/day, oral.

3, efficacy determination:

(1) cure: burn the clinical symptom disappearance such as sense of discomfort or causalgia, heartburn, acid regurgitation and dysphagia after breastbone, above disappear Change road barium meal x-ray inspection or scope and biopsy recovers normal.

(2) take a turn for the better: burn sense of discomfort after breastbone or the clinical symptoms such as causalgia, dysphagia disappears substantially, but the most occasionally have burning The symptom such as the heart, acid regurgitation occurs, and upper digestive tract barium meal x-ray inspection or scope and biopsy are clearly better.

(3) invalid: symptom is with treating front no significant difference.

4, result

Treatment group cure rate 63.2%, total effective rate 92.1%, matched group cure rate 44.7%, total effective rate are 78.9%, two groups of comparitive study, difference has a statistical significance (P < 0.05), therefore treatment group is substantially better than for the curative effect of primary disease Matched group.

1 liang of table group patient clinical comparitive study

Model case is illustrated:

1, Cai's ××, man, 37 years old.Causalgia after this patient's breastbone, acid regurgitation, belch, poor appetite are many for half a year.Institute's inquiring later, Being diagnosed as Reflux exophagitis on inspection, after taking 2 courses for the treatment of of Chinese medicine of the present invention, readme above-mentioned symptom disappears substantially. Following the doctor's advice after continuing to take 1 course for the treatment of of Chinese medicine of the present invention, clinical symptoms is wholly absent, and endoscopy is normal, after drug withdrawal with Visit and do not recur for 3 months, fully recover.

2, neat ××, female, 48 years old.This patient burns sense of discomfort after breastbone over nearly 3 months, has pantothenic acid, heartburn time after meal Etc. symptom, institute's inquiring later, it is diagnosed as Reflux exophagitis on inspection, after taking 2 courses for the treatment of of Chinese medicine of the present invention, faces Bed symptom is wholly absent, and endoscopy is normal, follows up a case by regular visits to 3 months not recur, fully recover after drug withdrawal.

3, Lee's ××, female, 57 years old.This patient occurs that discomfort is burnt in gastral cavilty portion the most often, accompanies the symptom such as acid regurgitation, belch 1 Nian Duo, later institute's inquiring, be diagnosed as Reflux exophagitis on inspection, after taking 3 courses for the treatment of of Chinese medicine of the present invention, clinical Symptom is wholly absent, and endoscopy is normal, follows up a case by regular visits to 3 months not recur, fully recover after drug withdrawal.

Reflux exophagitis develops, and is owing to many factors causes the anti-reflux defense mechanism of esophagus to decline and reflux The thing result to esophageal mucosa stimulation.Primary disease belongs to the traditional Chinese medical science " acid regurgitation ", " acid regurgitation ", " regurgitation ", " noisy ", " dysphagic ", " stomach Painful abdominal mass ", the category such as " thoracic obstruction ", it is unsuccessful that primary disease mostly is feelings will, eating and drinking without temperance, and work and rest is excessive, causes the liver failing to maintain the normal flow of QI, and dysfunction of the spleen in transportation goes out Existing stomach-QI being unable to descend normally, superinverse is in esophagus, and esophagus loses in moistening foster, and logical fall is unfavorable and falls ill.The present invention through long-term clinical practice, selected medicine The property of medicine of material is suitable mutually auxiliary mutually, suits the remedy to the case according to the cause of disease, and the Radix Astragali, Semen oryzae sativae in side, Radix Fici beecheyanae can invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach； Herba Limnophilae rugosae in side, Herba Lysimachiae can invigorating spleen to remove dampness, activating QI to eliminate phlegm, relieving stranguria by diuresis；Rhizoma Cyperi, Radix Curcumae, Fructus Citri Sarcodactylis, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Fructus Evodiae in side Can liver-smoothing, qi-regulating, promoting QI circulation for relieving depression, stomach function regulating reduce phlegm；Radix Adenophorae (Radix Glehniae) in side, Radix Ophiopogonis can replenishing YIN and removing heat, reinforcing stomach reg fluid；Massa Medicata Fermentata, Lay in side Fu leaf, Fructus Viticis Negundo can invigorating the spleen and regulating the stomach, regulate the flow of vital energy help digestion, promoting digestion and removing stagnation；Pericarpium Arecae in side, Caulis et Folium Oryzae, Fructus Amomi can be opened in therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, removing dampness Stomach；Pericarpium Citri in side, Chinese onion root, Emmenopterys henryi oliv. can be regulated the flow of vital energy the chest stuffiness relieving, stopping nausea and vomiting by lowering the adverse flow of QI；Herba Trigonotidis peduncularis in side, Concha Arcae can removing toxic substances and promoting subsidence of swelling, antacid Pain relieving；In side, Radix Glycyrrhizae can invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription；In side, all medicines share and can play invigorating the spleen and replenishing QI, invigorating spleen to remove dampness, stomach reinforcing life altogether Reduce phlegm in Tianjin, liver-smoothing, qi-regulating, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, stomach function regulating, promoting digestion and removing stagnation, stopping nausea and vomiting by lowering the adverse flow of QI, effect of relieving gastric hyperacidity to alleviate stomachache, good absorbing effect, treat Effect is notable, has no side effect and clinical adverse, higher to Reflux exophagitis cure rate according to clinical verification.

Claims

1. the instant particles as Chinese medicine being used for treating Reflux exophagitis, it is characterised in that: make the former of described effective ingredient Material forms and parts by weight are:

A kind of instant particles as Chinese medicine for treating Reflux exophagitis the most according to claim 1, it is characterised in that: make institute State effective ingredient raw material composition and parts by weight be:

The preparation method of a kind of instant particles as Chinese medicine for treating Reflux exophagitis the most according to claims 1 to 3, it is special Levy and be: comprise the following steps that:

(1) by Caulis et Folium Oryzae, Herba Trigonotidis peduncularis, Chinese onion root, Radix Fici beecheyanae, Radix Adenophorae (Radix Glehniae), Herba Lysimachiae, Semen oryzae sativae, Radix Ophiopogonis, Herba Limnophilae rugosae, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Radix Raphani Leaf, Emmenopterys henryi oliv., Fructus Citri Sarcodactylis, Fructus Viticis Negundo, Pericarpium Arecae, Pericarpium Citri, Fructus Evodiae are cleaned, are dried rear mix homogeneously, put in container, are holding Device adds the water of 6～8 times amount, heated and boiled 2～3 hours, after cooling, takes immersion；4～6 times are added in remaining medicinal residues The water of amount, heated and boiled 1～2 hours, take immersion after cooling；Merging twice gained immersion, heating, evaporation and concentration is relative density The thick paste of 1.15～1.25, standby；

(2) astragalus mongholicus tablet is added cooked Mel and a little boiled water, mixes thoroughly the most vexed, fry in putting pot to yellow and tack-free time, take out Drying in the air cool, pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(3) taking Massa Medicata Fermentata, be cut into small pieces, fry sallow to surface with slow fire, take out, cool, pulverizing is ground into powder, crosses 100 mesh dusting covers, Fine powder, standby；

(4) take clean Radix Glycyrrhizae tabellae, add cooked Mel and a little boiled water, the most vexed after mixing thoroughly, to put in parch container, slow fire is fried to deeply Yellow, takes out time tack-free, cools, and pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(5) take Rhizoma Cyperi and clean section, add quantitative rice vinegar and mix thoroughly, after moistening is sucked to vinegar, puts in parch container, add with slow fire Propagandizing hotly dry, taking-up is dried in the air cool, and sieve goes chip, pulverizing to grind into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(6) taking clean Concha Arcae and put in appropriate vessel, in smokeless stove fire, be calcined to crisp, taking-up cools, and pulverizing is ground into powder, crosses 100 Mesh dusting cover, obtains fine powder, standby；

(7) Radix Curcumae sheet is mixed thoroughly with rice vinegar, vexed, puts the interior slow fire of pot and heats fried dry, and taking-up cools, and sieve goes chip, pulverizing to grind into powder, Cross 100 mesh dusting covers, obtain fine powder, standby；

(8) taking clean Fructus Amomi, mix thoroughly with saline soak, slow fire is fried to micro-dry, and taking-up cools, and pulverizing is ground into powder, crosses 100 mesh dusting covers, Fine powder, standby；

(9) by the thick paste of step (1) gained, with step (2), step (3), step (4), step (5), step (6), step (7), In step (8), the fine powder mixing of gained, adds adjuvant sucrose and dextrin mix homogeneously makes granule, is dried, after granulate, is packaged into every The instant particles as Chinese medicine of bag 10g.