CN105497782A

CN105497782A - Traditional Chinese medicine pill used for treating kidney stones and preparation method thereof

Info

Publication number: CN105497782A
Application number: CN201510956953.XA
Authority: CN
Inventors: 夏修菲
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-12-18
Filing date: 2015-12-18
Publication date: 2016-04-20

Abstract

The invention discloses a traditional Chinese medicine pill used for treating kidney stones and a preparation method thereof and belongs to the field of traditional Chinese medicine. The pill is prepared from Chinese yam, christina loosestrife herb, dried radix rehmanniae, fructus lycii, polyporus umbellatus, radix codonopsis roots, fructus schizandrae, black sesame, lygodium japonicum, atractylodes macrocephala koidz, cortex phellodendri, polygonum aviculare L., tangerine seeds, aspidopterys glabriuscula, herba leonuri, poria, English walnut seeds, mirabilite, herb of herba cirsii, curcuma zedoary, stigma maydis, fish otolith, herba houttuyniae, liquorice roots and fructus forsythiae. The selected medicine materials cooperate with and supplement one another in medicine property according to the assistant and guide principle, the pill is used according to disease causes and symptoms such as kidney-qi deficiency and qi and strength sufficiency causing kidney stones, and the pill has the effects of clearing away heat and promoting diuresis, treating stranguria to eliminate stones, nourishing yin and clearing away heat, invigorating the spleen and the kidneys, promoting qi to activate blood circulation, removing toxicity for detumescence, stopping bleeding and relieving pain. The pill is good in absorbing effect, remarkable in treatment effect, free of toxic and side effects and clinical adverse effects and high in kidney stone cure rate through clinical verification.

Description

A kind of medicine pill and preparation method being used for the treatment of nephrolith disease

Art

The present invention relates to the field of Chinese medicines, particularly relate to a kind of medicine pill and the preparation method that are used for the treatment of nephrolith disease.

Background technology

Nephrolith disease refers to the calculus betiding renal calices, renal pelvis and renal pelvis and ureter connecting portion.Majority is positioned at renal pelvis renal calices, and excess of the kidney matter calculus is rare.There is the fine and close shadow of single or multiple circle, oval or obtuse triangle in plain film display kidney district, high and uniform density.How smooth edge is, but also have rough in Fructus Mori shape.Kidney is the lithogenous main portions of urinary system shape, the calculus at other any positions can be primary in kidney, ureteral calculus is almost all from kidney, and renal calculus coup injury kidney easier in other any position calculus, and therefore early diagnosis and therapy is extremely important.

Current western medical treatment mainly contains 3 kinds of Therapeutic Method such as litholytic therapy, extracorporeal shock wave, surgical calculus removing.Wherein litholytic therapy is better to urate calculus and cystine stone curative effect, but to containing calcium calculus and Infective calculus curative effect poor, versatility is strong, and side effect is large, is suitable for very much the patient that child and some have a delicate constitution.And the Therapeutic Method of extracorporeal shock wave and surgical calculus removing, although for some larger diameters and calculus in irregular shape, effective instant effect, comparatively large to patient body infringement, and costly, easily recurrence after curing.

The traditional Chinese medical science is thought, nephrolith disease belongs to the category of " stranguria " in the traditional Chinese medical science, i.e. damp invasion of lower energizer, and fire-transformation impairment of YIN, decocts body fluid, and condensation forms sandstone.Current Chinese traditional treatment method is main mainly with clearing away heat-damp and promoting diuresis, Tonglin Paishi.

Pill of the present invention, suits the remedy to the case for the cause of disease, can clearing away heat-damp and promoting diuresis, Tonglin Paishi, has effect of nourishing YIN and clearing away heat, strengthening spleen, tonifying kidney, promoting flow of QI and blood, removing toxic substances and promoting subsidence of swelling, hemostasis and pain-relieving concurrently.Instant effect, evident in efficacy, have no side effect and clinical adverse, higher to nephrolith disease cure rate through clinical verification.

Summary of the invention

The invention provides a kind of medicine pill and the preparation method that are used for the treatment of nephrolith disease, there is effect of clearing away heat-damp and promoting diuresis, Tonglin Paishi, nourishing YIN and clearing away heat, strengthening spleen, tonifying kidney, promoting flow of QI and blood, removing toxic substances and promoting subsidence of swelling, hemostasis and pain-relieving, cure the disease and ask source treating both the principal and secondary aspects of a disease, to the nephrolith disease that a variety of causes causes, all there is good curative effect.

For achieving the above object, technical scheme of the present invention is implemented as follows:

Be used for the treatment of a medicine pill for nephrolith disease, raw material composition and the parts by weight of making described effective ingredient are:

Rhizoma Dioscoreae 65 ~ 85 portions of Herba Lysimachiaes 62 ~ 80 parts of Radix Rehmanniae 58 ~ 76 parts of Fructus Lycii 55 ~ 73 parts

Polyporus 52 ~ 70 parts of Radix Codonopsis 48 ~ 67 parts of Fructus Schisandrae Chinensis 45 ~ 63 portions of Semen Sesami Nigrums 43 ~ 57 parts

Spora Lygodii 40 ~ 55 parts of Rhizoma Atractylodis Macrocephalaes 37 ~ 52 portions of Cortex Phellodendris 34 ~ 47 parts of Herba Polygoni Avicularis 32 ~ 45 parts

Semen Citri Reticulatae 30 ~ 42 parts of Caulis Aspidopterydis obcordataes 28 ~ 40 parts of Herba Leonuris 25 ~ 37 parts of Poria 22 ~ 35 parts

Semen juglandis 20 ~ 33 parts of Natrii Sulfas 18 ~ 30 portions of Herba Cirsiis 15 ~ 27 parts of Rhizoma Curcumae 12 ~ 24 parts

4 ~ 9 parts, Stigma Maydis 10 ~ 20 parts of Asteriscus Pseudosciaenaes 8 ~ 15 parts of Herba Houttuyniae 6 ~ 14 portions of Radix Glycyrrhizaes

Fructus Forsythiae 2 ~ 6 parts.

Raw material composition and the parts by weight of making described effective ingredient are:

Rhizoma Dioscoreae 70 ~ 80 portions of Herba Lysimachiaes 66 ~ 75 parts of Radix Rehmanniae 62 ~ 72 parts of Fructus Lycii 59 ~ 70 parts

Polyporus 56 ~ 66 parts of Radix Codonopsis 52 ~ 62 parts of Fructus Schisandrae Chinensis 49 ~ 58 portions of Semen Sesami Nigrums 46 ~ 54 parts

Spora Lygodii 44 ~ 51 parts of Rhizoma Atractylodis Macrocephalaes 40 ~ 48 portions of Cortex Phellodendris 37 ~ 44 parts of Herba Polygoni Avicularis 35 ~ 42 parts

Semen Citri Reticulatae 33 ~ 40 parts of Caulis Aspidopterydis obcordataes 31 ~ 36 parts of Herba Leonuris 28 ~ 34 parts of Poria 25 ~ 32 parts

Semen juglandis 23 ~ 30 parts of Natrii Sulfas 21 ~ 26 portions of Herba Cirsiis 18 ~ 23 parts of Rhizoma Curcumae 15 ~ 20

5 ~ 7 parts, part Stigma Maydis 12 ~ 16 parts of Asteriscus Pseudosciaenaes 10 ~ 14 parts of Herba Houttuyniae 8 ~ 12 portions of Radix Glycyrrhizaes

Fructus Forsythiae 3 ~ 5 parts.

Rhizoma Dioscoreae 76 portions of Herba Lysimachiaes 73 parts of Radix Rehmanniae 70 parts of Fructus Lycii 67 parts

Polyporus 64 parts of Radix Codonopsis 60 parts of Fructus Schisandrae Chinensis 56 portions of Semen Sesami Nigrums 52 parts

Spora Lygodii 48 parts of Rhizoma Atractylodis Macrocephalaes 45 portions of Cortex Phellodendris 42 parts of Herba Polygoni Avicularis 38 parts

Semen Citri Reticulatae 36 parts of Caulis Aspidopterydis obcordataes 34 parts of Herba Leonuris 31 parts of Poria 30 parts

Semen juglandis 27 parts of Natrii Sulfas 24 portions of Herba Cirsiis 20 parts of Rhizoma Curcumae 17 parts

6 parts, Stigma Maydis 14 parts of Asteriscus Pseudosciaenaes 12 parts of Herba Houttuyniae 9 portions of Radix Glycyrrhizaes

Fructus Forsythiae 4 parts.

Be used for the treatment of a preparation method for the medicine pill of nephrolith disease, comprise following processing step:

(1) Herba Lysimachiae, the Radix Rehmanniae, Fructus Lycii, Polyporus, Semen Sesami Nigrum, Spora Lygodii, Caulis Aspidopterydis obcordatae, Herba Leonuri, Poria, semen juglandis, Natrii Sulfas, Herba Cirsii, Rhizoma Curcumae, Stigma Maydis, Asteriscus Pseudosciaenae, Herba Houttuyniae, Radix Glycyrrhizae, Fructus Forsythiae are cleaned, dried rear mix homogeneously, put into container, add the water of 6 ~ 8 times amount in a reservoir, heated and boiled 2 ~ 3 hours, gets immersion after cooling; The water of 4 ~ 6 times amount is added again, heated and boiled 1 ~ 2 hour, immersion after cooling in remaining medicinal residues; Merge twice gained immersion, heating, evaporation and concentration is the thick paste of relative density 1.15 ~ 1.25, for subsequent use;

(2), after Radix Codonopsis, Fructus Schisandrae Chinensis, Herba Polygoni Avicularis being cleaned, put into container, add the shao-hsing rice wine of 3 ~ 5 times amount, cool after boiling, continue immersion 3 ~ 5 hours, get immersion; In remaining medicinal residues, add the shao-hsing rice wine of 2 ~ 4 times amount again, put after boiling and dry in the air, continue immersion 2 ~ 4 hours, get immersion; Merge twice gained immersion, add and steam the thick paste that evaporation and concentration is relative density 1.10 ~ 1.20, for subsequent use;

(3) Rhizoma Atractylodis Macrocephalae is put into iron pan, the micro-stir-fry of slow fire, fry after turning yellow to epidermis, spray Ji Me Lao Jiu, after continuation stir-fry is sallow to epidermis, taking-up cools, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(4) first by even for wheat bran spreading in hot pot, cigarette of waiting rises, add yam slice stir to faint yellow for degree, take out, sieve remove wheat bran, cool, dry, pulverizing is ground into powder, cross 120 order dusting covers, obtain fine powder, for subsequent use;

(5) put into iron pan, the micro-stir-fry of slow fire by clean for Cortex Phellodendri, fry after turning yellow to epidermis, taking-up cools, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(6) cleaned by Semen Citri Reticulatae, mix thoroughly with saline, slightly vexed, put into pot, slow fire is fried to micro-yellow, and has fragrance degree of being, taking-up is dried, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(7) by the thick paste of step (1), step (2) gained, mix with the fine powder of gained in step (3), step (4), step (5), step (6), add after refined honey stirs, be prepared as the pill of 8 parts every.

The property of medicine of the present invention's Chinese medicine used is as follows:

Rhizoma Dioscoreae: sweet in the mouth; Property is put down.Enter lung; Spleen; Kidney channel.Spleen reinforcing; Support lung; Reinforce the kidney; Benefit essence.Cure mainly diarrhea due to hypofunction of the spleen; Lack of appetite edema; Cough and asthma due to lung deficiency; Quench one's thirst; Seminal emission; Leukorrhagia; To suffer from a deficiency of the kidney frequent micturition; Carbuncle is controlled in external; Scrofula." book on Chinese herbal medicine just " carries: " Rhizoma Dioscoreae, energy spleen invigorating tonify deficiency, grows essence and reinforce the kidney, control weakness, treat five kinds of strain and seven kinds of impairment." modern medicine study confirms, Rhizoma Dioscoreae can reduce blood glucose, regulates body to non-specific irritant reaction, and effectively the Immunosuppression effect of antagonism cyclophosphamide, stimulates intestinal motility, promotes that intestinal contents is emptying, in addition can also aid digestion, antidiarrheal, eliminate the phlegm.

Herba Lysimachiae: sweet in the mouth; Micro-hardship; Cool in nature.Enter liver; Gallbladder; Kidney; Urinary bladder channel.Relieving stranguria by diuresis; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Cure mainly liver and gall and urinary system calculus; Pyretic stranguria; Oedema due to nephritis; Jaundice due to damp-heat; Sore carbuncle; Venom; Traumatic injury.Modern medicine study confirms, Herba Lysimachiae mainly containing phenolic constituent and sterol, flavonoid, tannin, volatile oil, choline, potassium salt etc., has calculus, antibacterial, treating stranguria, antiinflammatory action, all has obvious inhibitory action to humoral immunization, cellular immunization.

The Radix Rehmanniae: sweet in the mouth; Bitter; Cold nature.GUIXIN; Liver; Kidney channel.Nourishing YIN and clearing away heat; Removing heat from blood is enriched blood.Cure mainly calentura excessive thirst; Interior-heat is quenched one's thirst; Hectic fever due to YIN-deficiency consumptive fever; Epidemic febrile disease sends out speckle; Haematemesis caused by heat in blood; Metrorrhagia; Hematuria; Have blood in stool; Blood deficiency and yellow complexion; Dizzy cardiopalmus; Insufficiency of blood amenorrhea." Japan hanako materia medica " carries: " control palpitation with fear labor bad, cardiopulmonary damage, and spit blood, epistaxis, married woman's metrorrhagia bruise, helps muscles and bones." modern medicine study confirms, the Radix Rehmanniae is effective immunostimulant, comprises multiclass aminoacid, the saccharide beneficial to human body, and have heart tonifying, diuresis, blood pressure lowering, blood sugar lowering, protect the liver, the pharmacological action such as antibacterial, hemocytes increasing.

Fructus Lycii: sweet in the mouth; Property is put down.Return liver; Kidney; Lung meridian.Nourishing the liver; Nourishing kidney; Lung moistening.Cure mainly caused by liver and kidney deficiency; Have a dizzy spell; Visual one clear; Soreness of the waist and knees; The expensive essence of sexual impotence; Cough due to consumptive disease; To quench one's thirst taking fluids profusely." book on Chinese herbal medicine just " carries: " improve visual and auditory acuity, adds the solid marrow of essence, strengthen the muscle and bone, and kind benefit impairment caused by overstrain, especially only quenches one's thirst." modern medicine study confirm, Fructus Lycii scalable body's immunity, can effectively Tumor suppression grow and cell mutation, there is the effect of the aspect such as slow down aging, anti-fatty liver, adjusting blood lipid and blood glucose, promotion hemopoietic function.

Polyporus: sweet in the mouth; Light; Property is put down.Enter spleen; Kidney; Lung; Urinary bladder channel.Diuresis eliminating dampness by diuresis; Cure mainly dysuria; Edema distension; Foot gas; Have loose bowels; Stranguria with turbid discharge; Leukorrhagia." detailed outline " carries: " loosing the interspaces of skin and muscles controls pouring, swollen, beriberi, nebulousurine, leukorrhagia, pregnant stranguria during pregnancy, dysuria." modern medicine study confirmation, Polyporus can suppress renal tubules to water and electrolytical heavy absorption, thus has significant diuresis, and water and alcohol extract have Promote immunity and antibacterial action, can be used for the various edema of retention of water-damp.

Radix Codonopsis: sweet in the mouth; Property is put down.Return spleen; Lung meridian.Strengthening the spleen and tonifying the lung; Supplementing QI for promoting the production of body fluid.Cure mainly weakness of the spleen and stomach; Anorexia and loose stool; Limbs fatigue; The deficiency of the lung is breathed with cough; To breathe hard spontaneous perspiration; The all cards of deficiency of both QI and blood." moral joins book on Chinese herbal medicine " carries: " lung heat clearing gold, invigorating primordial QI, opens sound, helps biceps." modern medicine study confirms; Radix Codonopsis energy Gastrointestinal motility adjustment, antiulcer, enhancing immunologic function; on excited and suppress two kinds of nervous process to have impact, can raise erythrocyte, hemoglobin, reticulocyte, also have the effect of slow down aging and antioxidation, radioprotective, blood pressure lowering.

Fructus Schisandrae Chinensis: acrid in the mouth; Bitter; Warm in nature.Restrain astringent or styptic treatment for spontaneous sweating; Supplementing QI for promoting the production of body fluid; Kidney calming; Expelling wind and removing dampness; Vital energy regualting and blood circulation-promoting.Cure mainly rheumatic ostalgia; Traumatic injury; Stomachache; Menoxenia; Nephritis." herbal classic " carries: " main QI invigorating, cough with dyspnea, the thin degree of impairment caused by overstrain, tonifying for the deficiency, reinforcing YIN-essence." modern medicine study confirms; Fructus Schisandrae Chinensis contains abundant organic acid, vitamin, flavonoid, phytosterol and has the lignan of potent reactivation; it is also one of the minority medical material having essence, gas, god's three large tonifications concurrently, can the strong liver of QI invigorating, the efficiency of promoting cells exclude refuse, supply more oxygen, construction and utilization energy, raising memory and property endurance.

Semen Sesami Nigrum: property is put down, sweet in the mouth.Return Liver Channel, kidney channel, large intestine channel.Liver and kidney tonifying; The benefit that nourishes blood essence; Loosening bowel to relieve constipation.With the dizziness and tinnitus caused by treating the liver kidney deficiency, waist foot flaccidity is soft, beard and hair is early sent out, scaly dry skin; Dryness of the intestine constipation; Married woman's breast is few; Carbuncle skin ulcer eczema; Wind leprosy scrofula infections; Infantile scrofula; Burn; Hemorrhoid.Modern study proves: the fatty oil of Semen Sesami Nigrum, sesamin, vitamin E and various trace elements etc.There is reduction blood glucose, increase the content of glycogen in liver and muscle, increase the effect such as Vitamin C bolt and cholesterol level, defying age, relieving constipation, suppression adrenal cortex function in adrenal gland.

Spora Lygodii: sweet in the mouth; Light; Cold in nature; Nontoxic.Enter small intestinal; Spleen; Urinary bladder channel.Heat-clearing and toxic substances removing; Relieving stranguria by diuresis.Cure mainly pyretic stranguria; Stranguria with blood; Sha Lin; Nebulousurine; Woman's leukorrhagia; Water damp-edema is full; Damp-heat dysentery; Jaundice due to damp-heat; Spit blood; Epistaxis; Hematuria; Traumatic hemorrhage." Jiangxi medical herbs " carries: " heat-clearing and toxic substances removing, promoting urination to remove dampness.Treating the liver is scorching, renal edema, skin eczema, chickenpox, hematuria, mumps, acute toothache, throat moth, diphtheria, herpes zoster, infantile malnutrition." modern medicine study confirmation, Spora Lygodii is rich in fatty oil, and decoct is to staphylococcus aureus, bacillus pyocyaneus, shigella flexneri, Bacillus typhi etc., and all have significant inhibitory action, can increase bile secretion, contained caffeic acid also has function of gallbladder promoting hepatoprotective effect.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth; Sweet; Warm in nature.Return spleen; Stomach warp.Invigorating the spleen and benefiting QI; Dampness diuretic; Hidroschesis; Antiabortive.Cure mainly deficiency-weakness of spleen-QI; Spiritlessness and weakness; Lack of appetite abdominal distention; Large loose stool is thin; Fluid-retention stagnating in the interior; Dysuria; Edema; Dizziness due to fluid-retention; Arthralgia chiefly caused by damp pathogen is ached; Spontaneous sweating due to deficiency of QI; Frequent fetal movement." herbal classic is met former " carries: " art, raw with there being dehumidifying benefit dry, expectorant diuretic, controls anemofrigid-damp arthralgia, dead flesh convulsion subcutaneous ulcer, blood between loose waist umbilicus, and chong channel is disease, the merit of inverse gas pain in the abdomen; Make ripe, have and middle QI invigorating, slake thirst and help produce saliva, hidroschesis heat extraction, enters diet, antiabortive effect." modern medicine study confirmation, the Rhizoma Atractylodis Macrocephalae has effect that is strong and raising body resistance against diseases, strengthen the phagocytic function of reticuloendothelial system, strengthen the function of leukocytes phagocytic staphylococcus aureus, leukogenic effect is had to leukopenia, improve lymhocyte transformation rate, promote cellular immune function, to staphylococcus aureus, Hemolytic streptococcus, viridans streptococci, streptococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus subtilis has inhibitory action in various degree, to acrothesium floccosum, star-shaped nocardia, trichophyton, the dermatophytess such as Trichophyton concentricunm have certain inhibitory action.

Cortex Phellodendri: bitter in the mouth; Cold in nature.Enter kidney; Urinary bladder channel.Heat clearing and damp drying; Eliminating fire and detoxication.Cure mainly hygropyretic dysentery, have loose bowels, jaundice; Nocturnal emission, stranguria with turbid discharge, leukorrhagia; Hectic fever due to YIN-deficiency consumptive fever; And aphtha of the mouth and tongue; Conjunctival congestion and swelling pain; Skin sore; Skin eczema." medicineization justice " carries: " pathogenic fire reducing can capit ad calcem, and the thorough marrow of the skin that falls invariably thoughtfully, specially rushes down the fire of kidney and bladder." modern medicine study confirms, Cortex Phellodendri is containing the main component such as berberine, obacunone, and have the effect of antibacterial, convergence, antiinflammatory, to symptoms such as various skin noxious dampness, skin infection, effect is good.

Herba Polygoni Avicularis: bitter in the mouth; Cold nature.Return urinary bladder channel.Relieving stranguria by diuresis; Parasite killing dehumidifies.Cure mainly and drench pain; Eczema; Urinary system infection; Calculus; Hematuria; Enterobiasis; Skin sore rash; Pruritus.Shennong's Herbal carries: " cellulitis hemorrhoid, kill three worms for main contamination, scabies scabies, raw mountain valley." modern medicine study confirmation; Herba Polygoni Avicularis can increase the discharge of urine volume, sodium, potassium; have inhibitory action to trichophyton mentagrophytes, ulotrichy microspore bacterium, dysentery bacterium; suppress the growth of bacterium flexneri VI type and bacterium sonnei; water-ol extract can accelerate blood coagulation, has function of gallbladder promoting, boosting in addition.

Semen Citri Reticulatae: bitter in the mouth; Flat.Return liver; Kidney; Urinary bladder channel.Regulate the flow of vital energy; Eliminating stagnation; Pain relieving.Cure mainly: hernia; Painful and swollen testis; Acute mastitis; Lumbago." medical center bun is wanted ": profit kidney, hard kidney.Modern medicine study proves: Semen Citri Reticulatae has effect that is antipyretic, antibacterial, the smooth muscle that eases pain, expands.

Caulis Aspidopterydis obcordatae: lightly seasoned; Puckery; Cold nature.Return urinary bladder channel.Clearing away heat and promoting diuresis; Dispelling wind and removing obstruction in the collateral.Cure mainly: antiinflammatory diuresis, heat clearing away calculus.Control urinary tract infection, cystitis, lithangiuria, rheumatic ostalgia, puerperal asthenia, inappetence.

Herba Leonuri: acrid in the mouth; Bitter; Property micro-enter.Return liver; Kidney; Pericardium channel.Promoting blood flow to regulate menstruation; Inducing diuresis to remove edema; Heat-clearing and toxic substances removing.Cure mainly menoxenia; Amenorrhea; Vaginal bleeding during pregnancy is had difficult labour; Retention of placenta; Puerperal blood faints; Abdominal pain due to blood stasis; Traumatic injury; Dysuria; Edema; Carbuncle skin infection." book on Chinese herbal medicine is looked for the truth " carries: " disappear water promoting the circulation of blood, removes crazy tissue regeneration promoting, and regulating menstruation is detoxified, for wanting agent after tire front tyre." modern medicine study shows; the leonurines contained by Herba Leonuri etc. have excitation to uterus; antiplatelet aggregation, coagulation; improve coronary circulation, cardioprotection; strengthen cardiac contractile force; direct excited respiratory center, slow intestinal tube tonicity of speeding, and also have the effect such as CNS inhibition, bacteriostatic in addition.

Poria: property is flat, sweet in the mouth and, avirulence.GUIXIN, lung, spleen channel.Spleen invigorating, calm the nerves, calm, diuresis, also can promote body immune ability.For benefiting vital QI for tranquillizing, invigorating the spleen and regulating the stomach, dispels damp and hot, row water stopping leak, the disease such as treatment deficiency of vital energy impairment caused by overstrain, trusted subordinate's distension, edema, diarrhoea, forgetful, insomnia.The primary bioactive components of Poria is containing Multiple components such as three compounds and pachyman such as pachymic acid, the acid of layer hole, the acid of dehydrogenation layer hole, the acid of loose Siberian cocklebur.There is the effects such as anti-inflammatory, antioxidation, immunity moderation, calmness, emesis.Containing a large amount of β-pachyman in Poria sclerotium, also has pachymic acid, eburicoic acid, TA, the acid of loose Siberian cocklebur etc.In addition still containing ergosterol, choline, adenine, lecithin etc. is extraordinary medical material.

Semen juglandis: sweet in the mouth; Puckery; Warm in nature.Return kidney; Liver; Lung meridian.Tonifying the kidney to consolidate the essence; Warming the lung Dingchuan; Loosening bowel to relieve constipation.Cure mainly: lumbago flaccidity of the lower limbs; Frequent micturition; The enuresis; Sexual impotence; Seminal emission; Chronic cough dyspnea with rapid and short breath; Dryness of the intestine constipation; Stranguria caused by urinary stone and skin infection scrofula." Records of Tradition Chinese and Western Medicine in Combination ": Semen Juglandis is the key medicine of nourishing the liver and kidney, strong muscles and bones, therefore kind control pain in the lumbar region and have a pain in the leg, all bones and muscles pain.For it can the kidney invigorating, therefore can teeth consolidating tooth, black beard and hair, control asthenia and breathe heavily and cough, gas return unit, part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels deficiency and coldness, frequent micturition, all cards of woman's metrorrhagia and leukorrhagia.Its property heavily fortified point that can disappear again opens the stasis of blood, controls trusted subordinate's pain, and sand Stranguria, stranguria caused by urinary stone cane plug are done to ache, and kidney loses water of can not filtering, dysuria.Modern medicine proves: the phospholipid in semen juglandis, has fine health-care effect to cranial nerve.Walnut oil contains unsaturated fatty acid, has the arteriosclerotic effect of control.Containing indispensable trace element of human body such as zinc, manganese, chromium in semen juglandis, human body zinc, Fe content in aging course day by day reduce, and chromium has promotion glucose utilization, cholesterol metabolism and the cardiovascular function of protection.The antitussive and antiasthmatic effect of semen juglandis is also fairly obvious, winter, to chronic tracheitis and asthmatics's excellent curative.

Natrii Sulfas: acrid in the mouth; Bitter; Salty; Cold in nature.Enter stomach; Lung; Spleen; Kidney; Small intestinal; Three is burnt; Large intestine channel.Under softening the hard mass rushes down; Removing damp-heat; Removing blood stasis stimulates the menstrual flow; Skin ulcer is treated in detumescence.Cure mainly excess-heat to stagnate; Abdominal distention constipation; Retention of phlegm gathers; Conjunctival congestion is hidden from view; Erysipelas; Carbuncle." herbal classic " carries: " gas heavily fortified point person with softening masses by salty flavor it, intenseness of heat person disappears it with cold, hot excessive in interior, controls with salty-cold, helps with hardship." clinic study shows; the reticuloendothelial system of Natrii Sulfas to vermiform appendix and spleen has obvious stimulation, its hypertrophy phenomenon and phagocytic activity is strengthened to some extent, obviously alleviates appendicitis; can promote small intestinal, vermiform appendix and bag-shaped Colon Movement, transfers the resistance against diseases of body inherence.

Herba Cirsii: sweet in the mouth; Micro-hardship; Cool in nature.Enter liver; Spleen channel.Cooling blood for hemostasis; Clearing heat for detumescence.Cure mainly hemoptysis; Spit blood; Epistaxis; Hematuria; Stranguria with blood; Have blood in stool; Dysentery; Metrorrhagia and metrostaxis; Traumatic hemorrhage; Swollen ulcer drug." classifying herbal " carries: " control stranguria with blood to swell and ache, traumatic injury, redly to collapse, leucorrhea, heat clearing away, hemostasis, blood pressure lowering, dissipating blood stasis for subsidence of swelling.Control various hemorrhage, hypertension, jaundice, hepatitis, nephritis." modern medicine study confirmation, Herba Cirsii energy vasoconstrictive, increased platelets counts number, promotes platelet aggregation and increases thrombin activity, suppresses fibrinolysin, thus accelerates hemostasis.There is certain inhibitory action to diphtheria corynebacterium, streptococcus pneumoniae, Hemolytic streptococcus, staphylococcus aureus, bacillus pyocyaneus, Bacillus proteus, escherichia coli, Bacillus typhi etc., also have the effects such as blood fat reducing, function of gallbladder promoting, diuresis, heart tonifying, boosting in addition.

Rhizoma Curcumae: acrid in the mouth; Bitter; Warm in nature.Return liver; Spleen channel.Circulation of qi promoting removing blood stasis; Removing food stagnancy pain relieving.Cure mainly vim and vigour pained; Eating accumulation; Abdominal distention; Amenorrhea due to stagnation of blood; Dysmenorrhea; WEIJIA tumor mass in the abdomen; Traumatic injury." medicineization justice " carries: " acrid in the mouth is strong, specializes in the blood in gas, and main removing mass disappears heavily fortified point, goes to gather addiction block, amenorrhea blood stasis, flutters report pain." modern medicine study confirmation; the growth of Rhizoma Curcumae to multiple tumor strain has significantly suppression and destruction; have inhibitory action to tumor, the metabolism of cancerous cell core; significantly improve the content of lymphocytes in blood; strengthen oncocyte immunogenicity; temptation or promotion body, to the immunological rejection of tumor, improve the effect of radiation therapy.Take orally and decoct soup, grind into powder or enter ball and fall apart; External is decocted soup and is washed or grind into powder and dress.The how raw use of promoting the circulation of QI to relieve pain, removing blood stasis should be fried by vinegar.

Stigma Maydis: sweet in the mouth; Light; Property is put down.Return kidney; Stomach; Liver; Gallbladder meridian.Inducing diuresis to remove edema; Liver heat removing function of gallbladder promoting.Cure mainly: edema; Dribbling urination; Jaundice; Cholecystitis; Cholelithiasis; Hypertension; Diabetes; Galactostasis." modern Practical Chinese medicinal ": be diuretic, effective to nephropathy, edema illness, diabetes etc.It is again the active drug of cholecystitis, cholelithiasis, hepatic inflammatory jaundice etc.

Asteriscus Pseudosciaenae: sweet in the mouth; Salty; Cold in nature.Return urinary bladder channel.Inducing diuresis for treating stranguria syndrome; Heat-clearing and toxic substances removing.Cure mainly: stranguria caused by urinary stone; Dribbling urination is not smooth; Rhinitis; Suppurative otitis media." Japan hanako materia medica ": get pillow in brain and burn for end, under drink, control stranguria caused by urinary stone.

Herba Houttuyniae: acrid in the mouth; Cold in nature.Enter liver; Lung meridian.Heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; Inducing diuresis for treating stranguria syndrome.Cure mainly lung abscess vomiting pus; Expectorant dyspnea of heat type is coughed; Larynx; Hematodiarrhoea; Carbuncle sore tumefacting virus; Pyretic stranguria." conventional Chinese herbal medicine handbook " carries: " eliminating inflammation and expelling toxin, inducing diuresis to remove edema.Control upper respiratory tract infection, lung abscess, urinary tract inflammation and other position suppurative inflammation, venom." modern medicine study confirmation; Herba Houttuyniae can strengthen the phagocytic activity of WBC; improve immunity of organisms; all have inhibitory action to various microorganism, also has significant antagonism, antiviral, diuresis, analgesia, antitussive, hemostasis, suppression serous secretion in addition, promotes tissue regeneration, calmness, anticonvulsant action.

Radix Glycyrrhizae: sweet in the mouth; Property is put down.GUIXIN; Lung; Spleen; Stomach warp.Invigorating the spleen and replenishing QI; Heat-clearing and toxic substances removing; Expelling phlegm for arresting cough; Relieving spasm to stop pain; Coordinating the actions of various ingredients in a prescription.Cure mainly weakness of the spleen and stomach; Fatigue and weakness; Shortness of breath and palpitation; Cough with copious phlegm; Gastral cavity abdomen four muscle spasm of the leg and foot pain; Carbuncle sore tumefacting virus; Cushion toxicity.Compendium of Material Medica is carried: " in all medicines, Radix Glycyrrhizae is monarch.Control 72 kinds of mammary calculus poison, draft is malicious by every means to separate 1,002, is in harmonious proportion from medicine and gains merit." modern medicine study confirmation; Radix Glycyrrhizae has stronger Detoxication; also have antiulcer, anti-inflammatory, spasmolytic antitussive, blood pressure lowering, blood fat reducing, antitumaous effect; be widely used in the diseases such as treatment pharyngolaryngitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis, have anti-gastric-ulcer, gastritis effect in addition.

Fructus Forsythiae: bitter in the mouth; Cold nature.Enter lung; The heart; Gallbladder meridian.Heat-clearing and toxic substances removing; Dispersing swelling and dissipating binds.Cure mainly anemopyretic cold; Epidemic febrile disease; Pyretic stranguria urine retention; Carbuncle; Toxic swelling; Scrofula; Goiter; Sore throat.Shennong's Herbal carries: " main cold and heat, scrofula, scrofula, carbuncle malignant boil, goiter, stagnation of pathogenic heat." clinic study shows; Fructus Forsythiae has broad-spectrum antibacterial action; have very strong inhibitory action to staphylococcus aureus, Hayes dysentery bacterium; have certain inhibitory action to other pathogenic bacterium, influenza virus, fungus; contained oleanolic acid has heart tonifying, diuresis and hypotensive activity; Citrin can reduce vascular permeability and fragility, prevents haemolysis, also has antiinflammatory in addition, town is told, anti-liver injury effect.

The present invention compared with prior art, has following beneficial effect:

The present invention selects the property of medicine of medical material suitable mutually auxiliary mutually, suits the remedy to the case, have effect of clearing away heat-damp and promoting diuresis, Tonglin Paishi, nourishing YIN and clearing away heat, strengthening spleen, tonifying kidney, promoting flow of QI and blood, removing toxic substances and promoting subsidence of swelling, hemostasis and pain-relieving for the cause of disease such as deficiency of kidney-QI, filling of strength causing nephrolith disease.Good absorbing effect, evident in efficacy, have no side effect and clinical adverse, higher to nephrolith disease cure rate through clinical verification.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The raw material composition of effective ingredient of the present invention and weight are:

Rhizoma Dioscoreae 65 ~ 85g Herba Lysimachiae 62 ~ 80g Radix Rehmanniae 58 ~ 76g Fructus Lycii 55 ~ 73g

Polyporus 52 ~ 70g Radix Codonopsis 48 ~ 67g Fructus Schisandrae Chinensis 45 ~ 63g Semen Sesami Nigrum 43 ~ 57g

Spora Lygodii 40 ~ 55g Rhizoma Atractylodis Macrocephalae 37 ~ 52g Cortex Phellodendri 34 ~ 47g Herba Polygoni Avicularis 32 ~ 45g

Semen Citri Reticulatae 30 ~ 42g Caulis Aspidopterydis obcordatae 28 ~ 40g Herba Leonuri 25 ~ 37g Poria 22 ~ 35g

Semen juglandis 20 ~ 33g Natrii Sulfas 18 ~ 30g Herba Cirsii 15 ~ 27g Rhizoma Curcumae 12 ~ 24g

Stigma Maydis 10 ~ 20g Asteriscus Pseudosciaenae 8 ~ 15g Herba Houttuyniae 6 ~ 14g Radix Glycyrrhizae 4 ~ 9g

Fructus Forsythiae 2 ~ 6g.

The processing step of process for preparing medicine of the present invention is:

(7) by the thick paste of step (1), step (2) gained, mix with the fine powder of gained in step (3), step (4), step (5), step (6), add after refined honey stirs, be prepared as the pill of every 8g.

Usage and dosage: oral, every day 3 each 2 balls, one hour after meal with warm water delivery service, within 10 days, be a course for the treatment of.

Embodiment 2

Rhizoma Dioscoreae 70 ~ 80g Herba Lysimachiae 66 ~ 75g Radix Rehmanniae 62 ~ 72g Fructus Lycii 59 ~ 70g

Polyporus 56 ~ 66g Radix Codonopsis 52 ~ 62g Fructus Schisandrae Chinensis 49 ~ 58g Semen Sesami Nigrum 46 ~ 54g

Spora Lygodii 44 ~ 51g Rhizoma Atractylodis Macrocephalae 40 ~ 48g Cortex Phellodendri 37 ~ 44g Herba Polygoni Avicularis 35 ~ 42g

Semen Citri Reticulatae 33 ~ 40g Caulis Aspidopterydis obcordatae 31 ~ 36g Herba Leonuri 28 ~ 34g Poria 25 ~ 32g

Semen juglandis 23 ~ 30g Natrii Sulfas 21 ~ 26g Herba Cirsii 18 ~ 23g Rhizoma Curcumae 15 ~ 20g

Stigma Maydis 12 ~ 16g Asteriscus Pseudosciaenae 10 ~ 14g Herba Houttuyniae 8 ~ 12g Radix Glycyrrhizae 5 ~ 7g

Fructus Forsythiae 3 ~ 5g.

The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.

Embodiment 3

Rhizoma Dioscoreae 76g Herba Lysimachiae 73g Radix Rehmanniae 70g Fructus Lycii 67g

Polyporus 64g Radix Codonopsis 60g Fructus Schisandrae Chinensis 56g Semen Sesami Nigrum 52g

Spora Lygodii 48g Rhizoma Atractylodis Macrocephalae 45g Cortex Phellodendri 42g Herba Polygoni Avicularis 38g

Semen Citri Reticulatae 36g Caulis Aspidopterydis obcordatae 34g Herba Leonuri 31g Poria 30g

Semen juglandis 27g Natrii Sulfas 24g Herba Cirsii 20g Rhizoma Curcumae 17g

Stigma Maydis 14g Asteriscus Pseudosciaenae 12g Herba Houttuyniae 9g Radix Glycyrrhizae 6g

Fructus Forsythiae 4g.

Clinical data:

1, case selection

The routine clinical observation of nephrolith disease patient 80 selecting my institute to make a definite diagnosis, patient is divided into two groups at random.Treatment group 40 example, wherein male 23 example, women 17 example, 12 ~ 55 years old age, 32.6 years old mean age.Matched group 40 example, wherein male 24 example, women 16 example, 19 ~ 57 years old age, 31.4 years old mean age.Two groups of qualifications and record of service are basically identical, without significant difference, have comparability.

2, treatment group patient takes medicine of the present invention, oral, every day 3 each 2 balls, one hour after meal with warm water delivery service, within 10 days, be a course for the treatment of.Matched group, according to the classification of the nephrolith disease diagnosed out, gives the western medical treatment means such as litholytic therapy, extracorporeal shock wave, surgical calculus removing respectively.

3, efficacy determination:

(1) cure: clinical symptom disappearance, B ultrasonic shows, and renal calculus disappears.

(2) take a turn for the better: clinical symptom disappearance, B ultrasonic shows, and calculus reduces more than 1/3.

(3) invalid: clinical symptoms takes a turn for the better, B ultrasonic shows, and renal calculus is without obvious minimizing.

4, result

Cure 30 examples in treatment group, take a turn for the better 7 examples, invalid 3 examples, cure rate 75%, total effective rate 92.5%.

Cure 32 examples in matched group, take a turn for the better 6 examples, invalid 2 examples, cure rate 80%, total effective rate 95%.

The display of above result, the cure rate for the treatment of group and total effective rate close to the therapeutic effect of matched group, but adopt tcm therapy safe and reliable, have no side effect, and not easily recur after curing.

Model case is illustrated:

1, grandson's ××, man, 45 years old, office worker.This patient's lower abdomen pain, has hematuria phenomenon, comes institute and goes to a doctor, B ultrasonic display right side renal calculus 7mm, left renal calculus size 5mm.After taking 3 courses for the treatment of of pill of the present invention, clinical symptom disappearance, B ultrasonic shows, and renal calculus disappears, and rear tracking is not recurred for 3 months.

2, Lee's ××, female, 38 years old, workman.Patient's readme, has pain during right kidney nearest half a year, and has the slight soreness of waist to go up painful sense.Come institute to go to a doctor, B ultrasonic shows right lower calyx 8 millimeters of calculus, and after taking 2 courses for the treatment of of pill of the present invention, clinical symptom disappearance, B ultrasonic shows, and renal calculus disappears, and rear tracking is not recurred for 3 months.

The present invention selects the property of medicine of medical material suitable mutually auxiliary mutually, suit the remedy to the case for the cause of disease such as deficiency of kidney-QI, filling of strength causing nephrolith disease, Herba Lysimachiae, the treating stranguria fossil of Spora Lygodii energy in side, wherein Herba Lysimachiae can increase ureteral action potential, and have diuretic effect, be conducive to promoting ureteral calculus to move down, promote that calculus is discharged; Herba Polygoni Avicularis in side, Polyporus, Asteriscus Pseudosciaenae, Herba Houttuyniae can heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome; In side the Chinese medicine such as Rhizoma Dioscoreae, Fructus Lycii, Radix Codonopsis, Fructus Schisandrae Chinensis, Semen Sesami Nigrum, Rhizoma Atractylodis Macrocephalae can nourishing the liver nourishing kidney, invigorating the spleen and benefiting QI; In side the Chinese medicine such as the Radix Rehmanniae, Herba Cirsii can nourishing YIN and clearing away heat, cooling blood for hemostasis; In side, the Chinese medicine such as Cortex Phellodendri, Caulis Aspidopterydis obcordatae, Herba Leonuri, Stigma Maydis, Fructus Forsythiae can heat-clearing and toxic substances removing, inducing diuresis to remove edema; In side, the Chinese medicine such as Semen Citri Reticulatae, Natrii Sulfas, Rhizoma Curcumae can circulation of qi promoting removing blood stasis, regulating QI to relieve pain; Radix Glycyrrhizae relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription in side.All medicines share, voided volume can be increased, accelerate ureteral peristalsis frequency, lithodialysis pain relieving, effectively corrects the imbalance of function and the disorder of metabolism, makes body QI and blood, negative and positive are attributed to balance, calculus is discharged, evident in efficacy, have no side effect and clinical adverse, higher to nephrolith disease cure rate through clinical verification.

Claims

1. be used for the treatment of a medicine pill for nephrolith disease, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:

Fructus Forsythiae 2 ~ 6 parts.

2. a kind of medicine pill being used for the treatment of nephrolith disease according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:

Semen juglandis 23 ~ 30 parts of Natrii Sulfas 21 ~ 26 portions of Herba Cirsiis 18 ~ 23 parts of Rhizoma Curcumae 15 ~ 20 parts

5 ~ 7 parts, Stigma Maydis 12 ~ 16 parts of Asteriscus Pseudosciaenaes 10 ~ 14 parts of Herba Houttuyniae 8 ~ 12 portions of Radix Glycyrrhizaes

Fructus Forsythiae 3 ~ 5 parts.

3. a kind of medicine pill being used for the treatment of nephrolith disease according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:

Fructus Forsythiae 4 parts.

4. a kind of preparation method being used for the treatment of the medicine pill of nephrolith disease according to claims 1 to 3, is characterized in that: comprise following processing step: