CN106039205A - 一种用于治疗反流性食道炎的中药冲剂及制备方法 - Google Patents
一种用于治疗反流性食道炎的中药冲剂及制备方法 Download PDFInfo
- Publication number
- CN106039205A CN106039205A CN201610411574.7A CN201610411574A CN106039205A CN 106039205 A CN106039205 A CN 106039205A CN 201610411574 A CN201610411574 A CN 201610411574A CN 106039205 A CN106039205 A CN 106039205A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- fructus
- herba
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/342—Adenophora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种用于治疗反流性食道炎的中药冲剂及制备方法,属中药领域。本发明药物有效成分的原料组成为:稻草、附地菜、薤根、牛奶浆根、沙参、金钱草、粳米、麦门冬、黄芪、六神曲、甘草、水茴香、枸橘、莱菔叶、香附、香果树、佛手、瓦楞子、郁金、黄荆子、砂仁、大腹皮、香橼皮、吴茱萸。本发明选用药材符合君臣左使之理,针对病因对症下药,有补中益气、健脾利湿、益胃生津、舒肝理气、下气宽中、和胃化痰、消食化积、降逆止呕、制酸止痛之功效,吸收效果好,疗效显著,无毒副作用及临床不良反应,经临床验证对反流性食道炎治愈率较高。
Description
所属技术领域
本发明涉及中药领域,尤其涉及一种用于治疗反流性食道炎的中药冲剂及制备方法。
背景技术
反流性食道炎是因为胃内容物反流至食管引起,俗称“烧心病”,因为正常情况下胃酸只存在于胃中,当反流人食管时灼烧或刺激食管而产生“烧心感”。常常发生于饭后,因为食管***张力减弱或胃内压力高于食管而引起。胃内容物长期反复刺激食管黏膜,尤其是食管下段黏膜而引起炎症,该病经常与慢性胃炎、消化性溃疡或食道裂孔疝等病并存,但也可单独存在。主要症状为吞酸、吐酸、胸骨后烧灼不适感或灼痛,以及吞咽障碍等。
西医治疗本病主要从促进食管和胃的排空以及抑制中和胃酸入手对症治疗,如可用制酸剂中和胃酸,降低胃蛋白酶的活性。对胃排空延长可用胃动力药物如多潘立酮等,服用这些药物虽然见效较快,但治疗周期长,不能根治,病情易反复发作,且长期服用这些药物会产生一些副作用。
反流性食道炎根据临床表现可归属中医“吐酸”、“吞酸”、“反胃”、“嘈杂”、“噎膈”、“胃痞”、“胸痹”等范畴,在中医学中,肝属木,主疏泄,生发阳气,条达情志。胃属土,主受纳,以通为用。食管上及咽喉,下连脘腹,属胃所主,胃为水谷之海,与脾互为表里,共司受纳运化和输布功能,而脾胃运化与肝之疏泄功能相关,故本病病位在食道,与肝、胃、脾关系密切。故本病病因主要是由于情志不遂,饮食不节,劳逸过度,导致肝失疏泄,脾失健运,出现胃失和降,上逆于食道,食道失于濡养,通降不利而发病。本发明根据病因对症下药,具有补中益气、健脾利湿、益胃生津、舒肝理气、下气宽中、和胃化痰、消食化积、降逆止呕、制酸止痛之功效,吸收效果好,疗效显著,无毒副作用及临床不良反应,经临床验证对反流性食道炎治愈率较高。
发明内容
本发明提供了一种用于治疗反流性食道炎的中药冲剂及制备方法,具有补中益气、健脾利湿、益胃生津、舒肝理气、下气宽中、和胃化痰、消食化积、降逆止呕、制酸止痛之功效,治病求源标本兼治,对各种原因引起的反流性食道炎均具有很好的疗效。
为实现上述目的,本发明的技术方案实施如下:
一种用于治疗反流性食道炎的中药冲剂,制成所述药物有效成分的原料组成及重量份数为:
稻草65~80份、附地菜62~77份、薤根59~74份、牛奶浆根56~70份、
沙参53~66份、金钱草50~63份、粳米47~60份、麦门冬44~56份、
黄芪41~53份、六神曲39~50份、甘草36~46份、水茴香33~43份、
枸橘30~40份、莱菔叶26~37份、香附23~34份、香果树20~31份、
佛手17~28份、瓦楞子15~25份、郁金12~22份、黄荆子10~19份、
砂仁7~16份、大腹皮5~13份、香橼皮3~10份、吴茱萸1~8份。
制成所述药物有效成分的原料组成及重量份数为:
稻草68~77份、附地菜65~74份、薤根62~70份、牛奶浆根59~67份、
沙参56~63份、金钱草53~60份、粳米50~57份、麦门冬47~59份、
黄芪44~50份、六神曲42~47份、甘草39~43份、水茴香36~40份、
枸橘33~37份、莱菔叶29~34份、香附26~31份、香果树23~28份、
佛手20~25份、瓦楞子18~22份、郁金15~19份、黄荆子12~16份、
砂仁9~14份、大腹皮7~10份、香橼皮5~8份、吴茱萸2~5份。
制成所述药物有效成分的原料组成及重量份数为:
稻草73份、附地菜70份、薤根66份、牛奶浆根63份、
沙参60份、金钱草57份、粳米54份、麦门冬51份、
黄芪47份、六神曲44份、甘草41份、水茴香38份、
枸橘35份、莱菔叶32份、香附29份、香果树26份、
佛手23份、瓦楞子20份、郁金17份、黄荆子14份、
砂仁12份、大腹皮9份、香橼皮6份、吴茱萸3份。
一种用于治疗反流性食道炎的中药冲剂的制备方法,包括以下工艺步骤:
(1)将稻草、附地菜、薤根、牛奶浆根、沙参、金钱草、粳米、麦门冬、水茴香、枸橘、莱菔叶、香果树、佛手、黄荆子、大腹皮、香橼皮、吴茱萸洗净、晾干后混合均匀,放入容器中,在容器中加入6~8倍量的水,加热煮沸2~3小时,冷却后取浸液;在剩余的药渣中再加入4~6倍量的水,加热煮沸1~2小时,冷却后取浸液;合并两次所得浸液,加热,蒸发浓缩为相对密度1.15~1.25的稠膏,备用;
(2)将黄芪片加炼熟的蜂蜜与少许开水,拌匀稍闷,放锅内炒至黄色并不粘手时,取出晾凉,粉碎研末,过100目细筛,得细粉,备用;
(3)取六神曲,切成小块,用文火炒至表面焦黄,取出,放凉,粉碎研末,过100目细筛,得细粉,备用;
(4)取净甘草片,加入炼熟的蜂蜜与少许开水,拌匀后稍闷,置炒制容器内,文火炒至深黄色,不粘手时取出,放凉,粉碎研末,过100目细筛,得细粉,备用;
(5)取香附洗净切片,加定量的米醋拌匀,闷润至醋被吸尽后,置炒制容器内,用文火加热炒干,取出晾凉,筛去碎屑,粉碎研末,过100目细筛,得细粉,备用;
(6)取净瓦楞子置适宜容器内,于无烟的炉火中,煅至酥脆,取出放凉,粉碎研末,过100目细筛,得细粉,备用;
(7)郁金片加米醋拌匀,闷透,置锅内用文火加热炒干,取出放凉,筛去碎屑,粉碎研末,过100目细筛,得细粉,备用;
(8)取净砂仁,用盐水浸泡拌匀,文火炒至微干,取出放凉,粉碎研末,过100目细筛,得细粉,备用;
(9)将步骤(1)所得的稠膏,与步骤(2)、步骤(3)、步骤(4)、步骤(5)、步骤(6)、步骤(7)、步骤(8)中所得的细粉混合,加辅料蔗糖和糊精混合均匀制成颗粒,干燥、整粒后,封装成每袋10g的中药冲剂。
本发明所用中药的药性如下:
稻草:味辛;性温。归脾;肺经。宽中;下气;消食;解毒。主治噎膈;反胃;食滞;腹痛;泄泻;消渴;黄疸;喉痹;痔疮;烫火伤。
附地菜:味辛,苦;性平。归心;肝;脾;肾经。行气止痛;解毒消肿。主治胃痛吐酸;痢疾;热毒痈肿;手脚麻木。
薤根:味辛;苦;性温。归肺;心;胃;大肠经。理气宽胸;通阳散结。主治胸痹心痛彻背;胸脘痞闷;咳喘痰多;脘腹疼痛;泄痢后重;白带;疮疖痈肿。《纲目》:治少阴病厥逆泄痢,及胸痹刺痛,下气散血,安胎。温补助阳道。现代医学研究证明:薤根具有抑菌、降压利尿和抗癌作用,并具有扩张血管,抗血小板聚集,防止血栓形成,降低血脂的作用。
牛奶浆根:味甘;辛;性温。归肺;脾;肾经。益气健脾;活血通络;祛风除湿。主治劳倦乏力;食少;乳汁不下;脾虚白带;脱肛;***;头风疼痛;跌打损伤;风湿性关节痛。《闽东本草》:补中益气,健脾化湿,强筋壮骨,消肿,活血解毒。治中气虚弱,气血衰微,四肢酸软,筋骨不利,经闭,乳汁不通。
沙参:味甘;微苦;性微寒。归肺;胃经。养阴清热;润肺化痰;益胃生津。主治阴虚久咳;痨嗽痰血;燥咳痰少;虚热喉痹;津伤口渴。《本草纲目》载:“沙参甘淡而寒,其体轻虚,专补肺气,因而益脾与肾,故金能受火克者宜之。补阳而生阴,补阴而制阳,不可不辩之也。”现代医学研究证实,沙参含有挥发油、香豆素、淀粉、生物碱、三萜酸、豆甾醇、β-各甾醇,提高T细胞比值,提高淋巴细胞转化率,升高白细胞,增强巨噬细胞功能,延长抗体存在时间,有解热、镇痛、祛痰、平喘功能,增强体液和细胞的免疫功能,对应激性和药物性胃溃疡有保护和抑制作用。
金钱草:味甘;微苦;性凉。入肝;胆;肾;膀胱经。利水通淋;清热解毒;散瘀消肿。主治肝胆及泌尿系结石;热淋;肾炎水肿;湿热黄疸;疮毒痈肿;毒蛇咬伤;跌打损伤。现代医学研究证实,金钱草主要含酚性成分和甾醇、黄酮类、鞣质、挥发油、胆碱、钾盐等,具有排石、抑菌、通淋、抗炎作用,对体液免疫、细胞免疫均有明显的抑制作用。
粳米:味甘;性平。归脾;胃;肺经。补中益气,健脾和胃,除烦渴,止泻痢。主治脾胃气虚;食少纳呆;倦怠乏力;心烦口渴;泻下痢疾。《滇南本草》:治诸虚百损,强阴壮骨,生津,明目,长智。
麦门冬:味甘;微苦;性寒。归肺;胃;心经。滋阴润肺;益胃生津;清心除烦。主治肺燥干咳;肺痈;阴虚劳嗽;津伤口渴;消渴;心烦失眠;咽喉疼痛;肠燥便秘;血热吐衄。《本草汇言》:麦门冬,清心润肺之药也。主心气不足,惊悸怔忡,健忘恍惚,精神失守;或肺热肺燥,咳声连发,肺痿叶焦,短气虚喘,火伏肺中,咯血咳血;或虚劳客热,津液干少;或脾胃燥涸,虚秘便难;此皆心肺肾脾元虚火郁之证也。然而味甘气平,能益肺金,味苦性寒,能降心火,体润质补,能养肾髓,专治劳损虚热之功居多。如前古主心腹结气,伤中伤饱,胃络脉绝,羸瘦短气等疾,则属劳损明矣。
黄芪:味甘;性温。入心;肺;脾;肾经。补气固表;利尿;托毒排脓;生肌敛疮。主治气短心悸;倦怠;乏力;自汗;盗汗;久泻;脱肛;体虚浮肿;子宫脱垂;慢性肾炎;痈疽难溃;或溃久不敛。《新华本草纲要》载:“有补气固表、托毒排脓、生肌的功能。”现代医学研究证实,黄芪主要成分为黄芪总黄酮、黄芪总多糖、黄芪总皂苷和氨基酸等,具有利尿降压、消炎镇痛、强心、抗氧自由基生成及提高机体免疫功能等多种药理作用,可从多方面作用于机体,改善心血管、脑血管、糖尿病、肾病等相关血管性病变患者的血流动力学和血管内皮细胞等功能。
六神曲:味甘;辛;性温;无毒。入脾;胃经。健脾和胃;消食化积;主治饮食停滞;消化不良;脘腹胀满;食欲不振;呕吐泻痢。《本草正》载:“味甘气平,炒黄入药,善助中焦土脏,健脾暖胃,消食下气,化滞调中,逐痰积,破癥瘕,运化水谷,除霍乱胀满呕吐。其气腐,故能除湿热,其性涩,故又止泻痢。疗女人胎动因滞,治小儿腹坚因积。”现代医学研究证实,六神曲含多量酵母菌和B族维生素,能增进食欲,维持正常消化机能,同时还能帮助矿石类药物消化吸收。
甘草:味甘;性平。归心;肺;脾;胃经。补脾益气;清热解毒;祛痰止咳;缓急止痛;调和诸药。主治脾胃虚弱;倦怠乏力;心悸气短;咳嗽痰多;脘腹四肢挛急疼痛;痈肿疮毒;缓解药物毒性。《本草纲目》载:“诸药中甘草为君。治七十二种乳石毒,解一千二百般草本毒,调和从药有功。”现代医学研究证实,甘草有较强的解毒作用,还有抗溃疡、抗炎症、镇痉镇咳、降血压、降血脂、抗癌作用,广泛用于治疗咽喉炎、喉炎、气管炎、支气管炎、哮喘、咳嗽、咳血等疾病,此外还具有抗胃溃疡、抗胃炎作用。
水茴香:味辛;甘;性温。归肺;脾;胃经。健脾利湿;理气化痰。主治水肿;胃痛;胸腹胀满;咳嗽;小儿乳积;疮疖。《南宁市药物志》:"燥湿去痰,消肿止痛,杀虫解毒。治气喘咳嗽,小儿奶瘕,疮疖,蛇伤,胃寒痛。"
枸橘:味辛;苦;性温。归肝;胃经。疏肝和胃;理气止痛;消积化滞。主治胸胁胀满;脘腹胀痛;***结块;疝气疼痛;睾丸肿痛;跌打损伤;食积;便秘;子宫脱垂。《上海常用中草药》:利气,健胃,通便。治胃部胀满,消化不良,便秘,子宫脱垂,***结核。
莱菔叶:味辛;苦;性平。归脾;胃;肺经。消食理气;清肺利咽;散瘀消肿。主治食积气滞;脘腹痞满;呃逆;吐酸;泄泻;痢疾;咳谈;音哑;咽喉肿痛;妇女***肿痛;乳汁不通;外治损伤瘀肿。《滇南本草》:白萝卜杆叶,治脾胃不和,宿食不消,胸膈膨胀,噎膈,打呃,呕吐酸水,赤白痢疾,妇人乳结、乳肿,经闭。
香附:味辛;微寒;无毒。归肝;肺;脾;胃;三焦经。理气解郁;调经止痛;安胎。主治胁肋胀痛;***胀育;疝气疼痛;***;脘腹痞满疼痛;嗳气吞酸,呕恶;经行腹痛;崩漏带下;胎动不安。《纲目》散时气寒疫,利三焦,解女郁,消饮食积聚,痰饮痞满,跗肿,腹胀,脚气,止心腹、肢体、头、目、齿、耳诸痛,痈疽疮疡,吐血,下血,尿血,妇人崩漏带下,***,胎前产后百病。
香果树:味辛;甘;性微温。归胃经。湿中和胃;降逆止呕。主治反胃;呕吐;呃逆。
佛手:味辛;苦;性温。入肝;胃;脾;肺经。舒肝理气;和胃化痰。主治肝气郁结之胁痛;胸闷;肝胃不和;脾胃气滞之脘腹胀痛;喛气;恶心;久咳痰多。《本草再新》载:“治气舒肝,和胃化痰,破积,治噎膈反胃,消症瘕瘰疬。”现代医学研究证实,佛手有平喘祛痰作用,对抗气管收缩,迅速缓解胃、肠和胆囊的张力增加,延长惊厥发生时间,预防心律失常,增强毛血管的抵抗力,并具有抗炎的作用。
瓦楞子:味甘;咸;性平。入肝;脾;胃经。消痰化瘀;软坚散结;制酸止痛。主治瘰疬;癓瘕痞块;顽痰久咳;胃痛吐酸;牙疳;外伤出血;冻疮及烫火伤。《纲目》载:“咸走血而软坚,故能消血块,散痰积。”现代医学研究证实,瓦楞子用于治气血癓瘕有明显的疗效,富含大量碳酸钙,少量镁、铁、硅酸盐、硫酸盐和氯化物及有机质,对核素锰有特异的富集能力,临床上主要用于消肿止痛,活血化瘀。
郁金:味辛;苦;性寒。入心;肝;胆经。活血止痉;行气解郁;清心凉血;疏肝利胆。主治胸腹胁肋诸痛;妇女痛经;经闭;癓瘕结块;热病神昏;癫狂;惊痫;吐血;衄血;血淋;砂淋;黄疸。《本草备要》载:“行气,解郁;泄血,破瘀。凉心热,散肝郁,能开肺金之郁。”现代医学研究证实,郁金富含郁金多糖,具有增强网状内皮***活性,醇提物对纤维蛋白原有明显的影响,能降低主动脉中总胆固醇和甘油三酯含量。
黄荆子:味辛;苦;性温。归肺;胃;肝经。祛风解表;止咳平喘;理气消食止痛。主治伤风感冒;咳嗽;哮喘;胃痛吞酸;消化不良;食积泻痢;胆囊炎;胆结石;疝气。《广州植物志》载:“黄荆子祛风、涤痰、镇咳。”现代医学研究证实,黄荆子煎剂对支气管平滑肌有扩张作用,可解除气管、支气管痉挛。“
砂仁:味辛;性温。入脾;胃;肾经。化湿开胃;行气宽中;温脾;止泻;安胎。主治湿阻气滞;脘腹胀痛;不思饮食;恶心呕吐;腹痛泄泻;妊娠恶阻;胎动不安。《纲目》载:“补肺醒脾,养胃益肾,理元气,通滞气,散寒饮胀痞,噎膈呕吐,止女子崩中,除咽喉口齿浮热,化铜铁骨哽。”现代医学研究证实,砂仁能加强肠管收缩,大剂量时对肠管有抑制作用,表现张力降低,部分或完全拮抗乙酰胆碱,增进肠道运动,明显抑制血小板聚集,明显对抗胶原和肾上腺素的诱发作用。
大腹皮:味辛;性微温。入脾;胃;大肠;小肠经。下气宽中;行水消肿。主治胸腹胀闷;水肿;脚气;小便不利。《本草再新》载:“泻肺,和胃气,利湿追风,宽肠消肿,理腰脚气,治疟疾泻痢。“现代医学研究证实,大腹皮能提高肠管紧张性,减少收缩幅度,具有调节肠平滑肌的功能。
香橼皮:味辛;苦;酸;性温。入肝;肺;脾经。理气降逆;宽胸化痰。主治胸腹满闷;胁肋胀痛;咳嗽痰多。《本草再新》载:“平肝舒郁,理肺气,通经利水,治腰脚气。”现代医学研究证实,香橼皮所含挥发油对胃肠道有温和刺激作用,能促进肠胃里蠕动和消化液成分,排除肠内积气,并有祛痰、抗炎、抗病毒,以及预防冻伤和抑制醛还原酶的作用。
吴茱萸:味辛;苦;性热;小毒。入肝;胃;脾;大肠;肾经。散寒止痛;疏肝下气;温中燥湿。主治脘腹冷痛;厥阴头痛;疝痛;脚气肿痛;呕吐吞酸;寒湿泄泻。《本草纲目》载:“开郁化滞,治吞酸,厥阴痰涎头痛,阴毒腹痛,疝气,血痢,喉舌口呛。”现代医学研究证实,吴茱萸有镇吐,止泻,抗溃疡,抑制胃运动,强心,升血压,抗休克,改善微循环,提高免疫功能等作用。
本发明与现有技术相比,具有以下有益效果:
本发明选用药材君、臣、左、使诸理皆备,药性相适相辅,针对引发反流性食道炎的病因对症下药,有补中益气、健脾利湿、益胃生津、舒肝理气、下气宽中、和胃化痰、消食化积、降逆止呕、制酸止痛之功效,吸收效果好,疗效显著,无毒副作用及临床不良反应,经临床验证对反流性食道炎治愈率较高。
具体实施方式
下面结合具体实施例对本发明做进一步阐述。
实施例1
本发明药物有效成分的原料组成及重量为:
稻草65~80g、附地菜62~77g、薤根59~74g、牛奶浆根56~70g、
沙参53~66g、金钱草50~63g、粳米47~60g、麦门冬44~56g、
黄芪41~53g、六神曲39~50g、甘草36~46g、水茴香33~43g、
枸橘30~40g、莱菔叶26~37g、香附23~34g、香果树20~31g、
佛手17~28g、瓦楞子15~25g、郁金12~22g、黄荆子10~19g、
砂仁7~16g、大腹皮5~13g、香橼皮3~10g、吴茱萸1~8g。
本发明药物制备方法的工艺步骤为:
(1)将稻草、附地菜、薤根、牛奶浆根、沙参、金钱草、粳米、麦门冬、水茴香、枸橘、莱菔叶、香果树、佛手、黄荆子、大腹皮、香橼皮、吴茱萸洗净、晾干后混合均匀,放入容器中,在容器中加入6~8倍量的水,加热煮沸2~3小时,冷却后取浸液;在剩余的药渣中再加入4~6倍量的水,加热煮沸1~2小时,冷却后取浸液;合并两次所得浸液,加热,蒸发浓缩为相对密度1.15~1.25的稠膏,备用;
(2)将黄芪片加炼熟的蜂蜜与少许开水,拌匀稍闷,放锅内炒至黄色并不粘手时,取出晾凉,粉碎研末,过100目细筛,得细粉,备用;
(3)取六神曲,切成小块,用文火炒至表面焦黄,取出,放凉,粉碎研末,过100目细筛,得细粉,备用;
(4)取净甘草片,加入炼熟的蜂蜜与少许开水,拌匀后稍闷,置炒制容器内,文火炒至深黄色,不粘手时取出,放凉,粉碎研末,过100目细筛,得细粉,备用;
(5)取香附洗净切片,加定量的米醋拌匀,闷润至醋被吸尽后,置炒制容器内,用文火加热炒干,取出晾凉,筛去碎屑,粉碎研末,过100目细筛,得细粉,备用;
(6)取净瓦楞子置适宜容器内,于无烟的炉火中,煅至酥脆,取出放凉,粉碎研末,过100目细筛,得细粉,备用;
(7)郁金片加米醋拌匀,闷透,置锅内用文火加热炒干,取出放凉,筛去碎屑,粉碎研末,过100目细筛,得细粉,备用;
(8)取净砂仁,用盐水浸泡拌匀,文火炒至微干,取出放凉,粉碎研末,过100目细筛,得细粉,备用;
(9)将步骤(1)所得的稠膏,与步骤(2)、步骤(3)、步骤(4)、步骤(5)、步骤(6)、步骤(7)、步骤(8)中所得的细粉混合,加辅料蔗糖和糊精混合均匀制成颗粒,干燥、整粒后,封装成每袋10g的中药冲剂。
用法用量:口服,每次1袋,每日2次,早晚分服,饭前半小时以开水冲服,20天为1个疗程。
实施例2
本发明药物有效成分的原料组成及重量为:
稻草68~77g、附地菜65~74g、薤根62~70g、牛奶浆根59~67g、
沙参56~63g、金钱草53~60g、粳米50~57g、麦门冬47~59g、
黄芪44~50g、六神曲42~47g、甘草39~43g、水茴香36~40g、
枸橘33~37g、莱菔叶29~34g、香附26~31g、香果树23~28g、
佛手20~25g、瓦楞子18~22g、郁金15~19g、黄荆子12~16g、
砂仁9~14g、大腹皮7~10g、香橼皮5~8g、吴茱萸2~5g。
本实施例的药物制备方法工艺步骤及用法用量与实施例1相同。
实施例3
本发明药物有效成分的原料组成及重量为:
稻草73g、附地菜70g、薤根66g、牛奶浆根63g、
沙参60g、金钱草57g、粳米54g、麦门冬51g、
黄芪47g、六神曲44g、甘草41g、水茴香38g、
枸橘35g、莱菔叶32g、香附29g、香果树26g、
佛手23g、瓦楞子20g、郁金17g、黄荆子14g、
砂仁12g、大腹皮9g、香橼皮6g、吴茱萸3g。
本实施例的药物制备方法工艺步骤及用法用量与实施例1相同。
临床资料:
1、病例选择
选择我院确诊的反流性食道炎患者76例临床观察,病人随机分成两组。治疗组38例,其中男性16例,女性22例,年龄29~61岁,平均年龄42.7岁。对照组38例,其中男性14例,女性24例,年龄30~60岁,平均年龄42.1岁。两组资历基本一致,无显著差异,具有可比性。
2、治疗组患者服用本发明药物,口服,每次1袋,每日2次,早晚分服,饭前半小时以开水冲服,20天为1个疗程,服用3个疗程。对照组根据诊断出的反流性食道炎的病况,予以西药常规治疗,如予以兰索拉唑肠溶片15mg,2次/日,口服;氢氧化铝凝胶10ml,3次/日,口服;西沙比利片10mg,3次/日,口服。
3、疗效判定:
(1)治愈:胸骨后烧灼不适感或灼痛、烧心、反酸及吞咽困难等临床症状消失,上消化道钡餐X线检查或内镜及活组织检查恢复正常。
(2)好转:胸骨后烧灼不适感或灼痛、吞咽困难等临床症状基本消失,但还偶有烧心、反酸等症状发生,上消化道钡餐X线检查或内镜及活组织检查明显好转。
(3)无效:症状同施治前无明显差异。
4、结果
治疗组治愈率63.2%、总有效率92.1%,对照组治愈率44.7%、总有效率为78.9%,两组疗效比较,差异具有统计学意义(P<0.05),故治疗组对于本病的疗效明显优于对照组。
表1 两组患者临床疗效比较
典型病例举例:
1、蔡××,男,37岁。该患者胸骨后灼痛、吞酸、嗳气、纳差半年多。后来来院问诊,经检查诊断为反流性食道炎,经服用本发明所述中药2个疗程后,自述上述症状基本消失。遵医嘱继续服用本发明所述中药1个疗程后,临床症状完全消失,内镜检查正常,停药后随访3个月未复发,已痊愈。
2、齐××,女,48岁。该患者近3个月来胸骨后有烧灼不适感,饭后时有泛酸、烧心等症状,后来来院问诊,经检查诊断为反流性食道炎,经服用本发明所述中药2个疗程后,临床症状完全消失,内镜检查正常,停药后随访3个月未复发,已痊愈。
3、李××,女,57岁。该患者饭后时常出现胃脘部烧灼不适,伴反酸、嗳气等症状1年多,后来来院问诊,经检查诊断为反流性食道炎,经服用本发明所述中药3个疗程后,临床症状完全消失,内镜检查正常,停药后随访3个月未复发,已痊愈。
反流性食道炎的发生发展,是由于多种因素导致食道抗反流防御机制下降和反流物对食道黏膜刺激作用的结果。本病属中医“吐酸”、“吞酸”、“反胃”、“嘈杂”、“噎膈”、“胃痞”、“胸痹”等范畴,本病多为情志不遂,饮食不节,劳逸过度,导致肝失疏泄,脾失健运,出现胃失和降,上逆于食道,食道失于濡养,通降不利而发病。本发明经长期临床实践,所选药材的药性相适相辅,根据病因对症下药,方中黄芪、粳米、牛奶浆根可补中益气、健脾和胃;方中水茴香、金钱草可健脾利湿、理气化痰、利水通淋;方中香附、郁金、佛手、枸橘、吴茱萸可舒肝理气、行气解郁、和胃化痰;方中沙参、麦门冬可养阴清热、益胃生津;方中六神曲、莱菔叶、黄荆子可健脾和胃、理气消食、消食化积;方中大腹皮、稻草、砂仁可下气宽中、化湿开胃;方中香橼皮、薤根、香果树可理气宽胸、降逆止呕;方中附地菜、瓦楞子可解毒消肿、制酸止痛;方中甘草可补脾益气、调和诸药;方中诸药合用可共奏补中益气、健脾利湿、益胃生津、舒肝理气、下气宽中、和胃化痰、消食化积、降逆止呕、制酸止痛之功效,吸收效果好,疗效显著,无毒副作用及临床不良反应,经临床验证对反流性食道炎治愈率较高。
Claims (4)
1.一种用于治疗反流性食道炎的中药冲剂,其特征在于:制成所述药物有效成分的原料组成及重量份数为:
稻草65~80份、附地菜62~77份、薤根59~74份、牛奶浆根56~70份、
沙参53~66份、金钱草50~63份、粳米47~60份、麦门冬44~56份、
黄芪41~53份、六神曲39~50份、甘草36~46份、水茴香33~43份、
枸橘30~40份、莱菔叶26~37份、香附23~34份、香果树20~31份、
佛手17~28份、瓦楞子15~25份、郁金12~22份、黄荆子10~19份、
砂仁7~16份、大腹皮5~13份、香橼皮3~10份、吴茱萸1~8份。
2.根据权利要求1所述的一种用于治疗反流性食道炎的中药冲剂,其特征在于:制成所述药物有效成分的原料组成及重量份数为:
稻草68~77份、附地菜65~74份、薤根62~70份、牛奶浆根59~67份、
沙参56~63份、金钱草53~60份、粳米50~57份、麦门冬47~59份、
黄芪44~50份、六神曲42~47份、甘草39~43份、水茴香36~40份、
枸橘33~37份、莱菔叶29~34份、香附26~31份、香果树23~28份、
佛手20~25份、瓦楞子18~22份、郁金15~19份、黄荆子12~16份、
砂仁9~14份、大腹皮7~10份、香橼皮5~8份、吴茱萸2~5份。
3.根据权利要求1所述的一种用于治疗反流性食道炎的中药冲剂,其特征在于:制成所述药物有效成分的原料组成及重量份数为:
稻草73份、附地菜70份、薤根66份、牛奶浆根63份、
沙参60份、金钱草57份、粳米54份、麦门冬51份、
黄芪47份、六神曲44份、甘草41份、水茴香38份、
枸橘35份、莱菔叶32份、香附29份、香果树26份、
佛手23份、瓦楞子20份、郁金17份、黄荆子14份、
砂仁12份、大腹皮9份、香橼皮6份、吴茱萸3份。
4.根据权利要求1~3所述的一种用于治疗反流性食道炎的中药冲剂的制备方法,其特征在于:包括以下工艺步骤:
(1)将稻草、附地菜、薤根、牛奶浆根、沙参、金钱草、粳米、麦门冬、水茴香、枸橘、莱菔叶、香果树、佛手、黄荆子、大腹皮、香橼皮、吴茱萸洗净、晾干后混合均匀,放入容器中,在容器中加入6~8倍量的水,加热煮沸2~3小时,冷却后取浸液;在剩余的药渣中再加入4~6倍量的水,加热煮沸1~2小时,冷却后取浸液;合并两次所得浸液,加热,蒸发浓缩为相对密度1.15~1.25的稠膏,备用;
(2)将黄芪片加炼熟的蜂蜜与少许开水,拌匀稍闷,放锅内炒至黄色并不粘手时,取出晾凉,粉碎研末,过100目细筛,得细粉,备用;
(3)取六神曲,切成小块,用文火炒至表面焦黄,取出,放凉,粉碎研末,过100目细筛,得细粉,备用;
(4)取净甘草片,加入炼熟的蜂蜜与少许开水,拌匀后稍闷,置炒制容器内,文火炒至深黄色,不粘手时取出,放凉,粉碎研末,过100目细筛,得细粉,备用;
(5)取香附洗净切片,加定量的米醋拌匀,闷润至醋被吸尽后,置炒制容器内,用文火加热炒干,取出晾凉,筛去碎屑,粉碎研末,过100目细筛,得细粉,备用;
(6)取净瓦楞子置适宜容器内,于无烟的炉火中,煅至酥脆,取出放凉,粉碎研末,过100目细筛,得细粉,备用;
(7)郁金片加米醋拌匀,闷透,置锅内用文火加热炒干,取出放凉,筛去碎屑,粉碎研末,过100目细筛,得细粉,备用;
(8)取净砂仁,用盐水浸泡拌匀,文火炒至微干,取出放凉,粉碎研末,过100目细筛,得细粉,备用;
(9)将步骤(1)所得的稠膏,与步骤(2)、步骤(3)、步骤(4)、步骤(5)、步骤(6)、步骤(7)、步骤(8)中所得的细粉混合,加辅料蔗糖和糊精混合均匀制成颗粒,干燥、整粒后,封装成每袋10g的中药冲剂。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610411574.7A CN106039205A (zh) | 2016-06-14 | 2016-06-14 | 一种用于治疗反流性食道炎的中药冲剂及制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610411574.7A CN106039205A (zh) | 2016-06-14 | 2016-06-14 | 一种用于治疗反流性食道炎的中药冲剂及制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106039205A true CN106039205A (zh) | 2016-10-26 |
Family
ID=57170075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610411574.7A Pending CN106039205A (zh) | 2016-06-14 | 2016-06-14 | 一种用于治疗反流性食道炎的中药冲剂及制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106039205A (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104906554A (zh) * | 2015-07-16 | 2015-09-16 | 上海中医药大学附属岳阳中西医结合医院 | 一种治疗难治性胃食管反流病的中药组合物及其应用 |
-
2016
- 2016-06-14 CN CN201610411574.7A patent/CN106039205A/zh active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104906554A (zh) * | 2015-07-16 | 2015-09-16 | 上海中医药大学附属岳阳中西医结合医院 | 一种治疗难治性胃食管反流病的中药组合物及其应用 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103977358A (zh) | 一种降脂护肝的口服中药 | |
CN103830749B (zh) | 一种胃肠造影剂 | |
CN104524335A (zh) | 一种用于女性内分泌失调调理的药丸及制备方法 | |
CN103656461B (zh) | 一种治疗胃癌的中药蜜丸及制备方法 | |
CN102362974A (zh) | 一种治疗荨麻疹的中药组合物 | |
CN106389950A (zh) | 一种治疗慢性肾炎综合征蛋白尿的中药制剂 | |
CN105999110A (zh) | 一种用于治疗女性慢性盆腔疼痛的中药冲剂及制备方法 | |
CN106266961A (zh) | 一种脾胃病和肠胃病综合治疗的中药组合物及其制备方法 | |
CN105148122A (zh) | 一种用于治疗盆腔脓肿的中药丸剂及制备方法 | |
CN102580032B (zh) | 具有促排石作用的中药组合物片剂、散剂、口服液及制备方法 | |
CN105688002A (zh) | 一种用于治疗老年功能性便秘的中药冲剂及制备方法 | |
CN105362914A (zh) | 一种治疗慢性胃炎的中药组合物 | |
CN105168522A (zh) | 医治腹胀的药剂及制法 | |
CN104840874A (zh) | 一种用于动脉瘤术后康复治疗的中药丸剂及制备方法 | |
CN106039205A (zh) | 一种用于治疗反流性食道炎的中药冲剂及制备方法 | |
CN104491364B (zh) | 一种治疗慢性淋巴细胞性甲状腺炎的药丸及制备方法 | |
CN105816742A (zh) | 一种用于治疗胃窦炎的中药冲剂及制备方法 | |
CN106943573A (zh) | 一种治疗胃病的中药及其制备方法 | |
CN103055271B (zh) | 一种用于治疗慢性胃炎的药物及制备方法 | |
CN105381416A (zh) | 一种治疗上消化道出血的药物及其制备方法 | |
CN105497782A (zh) | 一种用于治疗肾石症的中药丸剂及制备方法 | |
CN105362843A (zh) | 治疗脾胃湿热型消化性溃疡的药物组合物及其制备方法 | |
CN105056093A (zh) | 一种治疗慢性胃及十二指肠溃疡的药物及其制备方法 | |
CN104189816A (zh) | 治疗腹胀的中药制剂 | |
CN104056228A (zh) | 一种治疗小儿厌食症的药物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161026 |