CN105943940A - 一种用于治疗过敏性鼻炎的中药组合物及其制剂的制备方法 - Google Patents
一种用于治疗过敏性鼻炎的中药组合物及其制剂的制备方法 Download PDFInfo
- Publication number
- CN105943940A CN105943940A CN201610572459.8A CN201610572459A CN105943940A CN 105943940 A CN105943940 A CN 105943940A CN 201610572459 A CN201610572459 A CN 201610572459A CN 105943940 A CN105943940 A CN 105943940A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- allergic rhinitis
- fructus
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 206010039085 Rhinitis allergic Diseases 0.000 title claims abstract description 29
- 201000010105 allergic rhinitis Diseases 0.000 title claims abstract description 29
- 239000003814 drug Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims description 17
- 239000000843 powder Substances 0.000 claims abstract description 8
- 239000003826 tablet Substances 0.000 claims abstract description 5
- 239000002671 adjuvant Substances 0.000 claims abstract description 4
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 239000008187 granular material Substances 0.000 claims abstract description 4
- 239000006187 pill Substances 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 20
- 241000237636 Pheretima Species 0.000 claims description 14
- 239000009636 Huang Qi Substances 0.000 claims description 12
- 210000000582 semen Anatomy 0.000 claims description 12
- 244000025254 Cannabis sativa Species 0.000 claims description 11
- 239000002994 raw material Substances 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000009835 boiling Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 15
- 241000721047 Danaus plexippus Species 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 239000002552 dosage form Substances 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 241000717682 Anisomeles Species 0.000 abstract 1
- 241000758794 Asarum Species 0.000 abstract 1
- 241000045403 Astragalus propinquus Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 241000931705 Cicada Species 0.000 abstract 1
- 241000110637 Cuscuta chinensis Species 0.000 abstract 1
- 244000286838 Eclipta prostrata Species 0.000 abstract 1
- 241000243684 Lumbricus Species 0.000 abstract 1
- 241000123069 Ocyurus chrysurus Species 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- 241000209140 Triticum Species 0.000 abstract 1
- 235000021307 Triticum Nutrition 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 235000021018 plums Nutrition 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 description 13
- 210000004072 lung Anatomy 0.000 description 13
- 210000003734 kidney Anatomy 0.000 description 10
- 210000000952 spleen Anatomy 0.000 description 10
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 230000007812 deficiency Effects 0.000 description 7
- 208000006820 Arthralgia Diseases 0.000 description 6
- 206010011224 Cough Diseases 0.000 description 6
- 239000013566 allergen Substances 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 206010003549 asthenia Diseases 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 208000008454 Hyperhidrosis Diseases 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 201000009890 sinusitis Diseases 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 206010003645 Atopy Diseases 0.000 description 3
- 206010010904 Convulsion Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 208000025747 Rheumatic disease Diseases 0.000 description 3
- 208000005392 Spasm Diseases 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 239000000812 cholinergic antagonist Substances 0.000 description 3
- 230000036461 convulsion Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000002175 menstrual effect Effects 0.000 description 3
- 230000027939 micturition Effects 0.000 description 3
- 210000003695 paranasal sinus Anatomy 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 230000000552 rheumatic effect Effects 0.000 description 3
- 230000002048 spasmolytic effect Effects 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 206010019468 Hemiplegia Diseases 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 201000005505 Measles Diseases 0.000 description 2
- 208000007101 Muscle Cramp Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 208000009205 Tinnitus Diseases 0.000 description 2
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 2
- 206010047513 Vision blurred Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 201000009361 ascariasis Diseases 0.000 description 2
- 210000003445 biliary tract Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 230000037315 hyperhidrosis Effects 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 210000002850 nasal mucosa Anatomy 0.000 description 2
- 230000036565 night sweats Effects 0.000 description 2
- 206010029410 night sweats Diseases 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 206010039083 rhinitis Diseases 0.000 description 2
- 201000005404 rubella Diseases 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 231100000886 tinnitus Toxicity 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 210000003932 urinary bladder Anatomy 0.000 description 2
- FLNXBVJLPJNOSI-UHFFFAOYSA-N 1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine Chemical compound C1=CC(Cl)=CC=C1C(C=1C=CC=CC=1)OCCN1CCCCC1 FLNXBVJLPJNOSI-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010002653 Anosmia Diseases 0.000 description 1
- 241000244186 Ascaris Species 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000036119 Frailty Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010050515 Hyposmia Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010037714 Quadriplegia Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 231100000354 acute hepatitis Toxicity 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 230000002590 anti-leukotriene effect Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 229960002544 cloperastine Drugs 0.000 description 1
- 239000000850 decongestant Substances 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000005182 global health Effects 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 235000019559 hyposmia Nutrition 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 201000005630 leukorrhea Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 206010041232 sneezing Diseases 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 206010046901 vaginal discharge Diseases 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Insects & Arthropods (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
一种治疗过敏性鼻炎的中药组合物,由黄芪1‑60份、白术1‑30份、防风1‑20份、五味子1‑20份、菟丝子1‑30份、细辛1‑6份、茜草1‑20份、豨签草1‑30份、蝉蜕1‑20份、乌梅1‑20份、地龙1‑30份、旱莲草1‑30份、浮小麦1‑30份、甘草1‑20份制成。药物剂型为:水煎剂、散剂、胶囊剂、片剂、颗粒剂或丸剂。本发明君、臣、佐、使各施其效,具有用药少,见效快,临床观察证实无毒副作用。
Description
技术领域
本发明涉及一种用于治疗过敏性鼻炎的中药组合物及其制剂的制备方法,属于中医药领域。
背景技术
过敏性鼻炎即变应性鼻炎,是指特应性个体接触变应原后,主要由IgE介导的介质(主要是组胺)释放,并有多种免疫活性细胞和细胞因子等参与的鼻黏膜非感染性炎性疾病。其发生的必要条件有3个:特异性抗原即引起机体免疫反应的物质;特应性个体即所谓个体差异、过敏体质;特异性抗原与特应型个体二者相遇。变应性鼻炎是一个全球性健康问题,可导致许多疾病和劳动力丧失。变应性鼻炎是一种由基因与环境互相作用而诱发的多因素疾病。变应性鼻炎的危险因素可能存在于所有年龄段。变应性鼻炎患者具有特应性体质,通常显示出家族聚集性。变应原是诱导特异性IgE抗体并与之发生反应的抗原,变应原主要分为吸入性变应原和食物性变应原,吸入性变应原是变应性鼻炎的主要原因。临床表现主要是阵发性喷嚏、清水样鼻涕、鼻塞和鼻痒。部分伴有嗅觉减退。治疗除了避免接触变应原,还有药物治疗,目前常用鼻内和口服给药,严重者可选择外科治疗。口服给药西药多为抗组胺药、糖皮质激素、抗白三烯药、鼻内减充血剂。部分中药对缓解症状有效。临床上有鼻炎康、鼻炎片等药物,缺点是疗效差,对过敏性鼻炎没有较好的治疗效果。效果不理想,容易反复,本发明针对病因起效,过敏性鼻炎无须手术,而且疗效肯定。
发明内容
针对现有技术的不足,本发明提供一种治疗过敏性鼻炎病的中药组合物及其制备方法。
本发明的技术方案如下:
一种治疗过敏性鼻炎的中药组合物,由以下重量份的原材料制成:
黄芪1-60份、白术1-30份、防风1-20份、五味子1-20份、菟丝子1-30份、细辛1-6份、茜草1-20份、豨签草1-30份、蝉蜕1-20份、乌梅1-20份、地龙1-30份、旱莲草1-30份、浮小麦1-30份、甘草1-20份。
作为上述技术案的进一步优选,所述中药组合物由以下重量份的原材料制成:
黄芪30份、白术15份、防风10份、五味子10份、菟丝子15份、细辛3份、茜草15份、豨签草15份、蝉蜕15份、乌梅15份、地龙15份、旱莲草15份、浮小麦15份、甘草10份。
根据本发明,一种治疗过敏性鼻炎的中药组合物制剂的制备方法,包括以下步骤:
a、将黄芪、白术、防风、五味子、菟丝子、细辛、茜草、豨签草、蝉蜕、乌梅、地龙、旱莲草、浮小麦、甘草一起混合,加水煎煮两次,滤过,合并滤液,浓缩至滤液体积的1/2,得浓缩液;
b、将步骤a所得的浓缩液浓缩至相对密度80℃测得1.20~1.24的稠浸膏;
c、将上述步骤b的稠浸膏混合均匀后移进烘箱,50-70℃烘干至水分低于5%,加入辅料按现有技术制成散剂、胶囊剂、片剂、颗粒剂或丸剂。
根据本发明,一种治疗过敏性鼻炎的中药组合物制剂的制备方法,包括按比例取各原料成分,混合,加水煎煮30分钟,成水煎剂。
所述中药组合物药物剂型为:水煎剂、散剂、胶囊剂、片剂、颗粒剂或丸剂。
在以上原料中:
黄芪:味甘性微温。归肺、脾、肝、肾经。补齐固表,托疮生肌。主治体虚自汗,久泻,脱肛,子宫脱垂,慢性肾炎,体虚浮肿,慢性溃疡,疮口久不愈合。
白术:补脾,益胃,燥湿,和中,安胎。治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,痰饮,水肿,黄疸,湿痹,小便不利,头晕,自汗,胎气不安。
防风:防风味辛、甘,性微温;归肺、脾、肝、膀胱经;气香升散;具有祛风解表,除湿止痛,疏肝解痉,杀虫止痒的功效;主治外感风寒,头痛项强,目眩昏涩,风寒湿痹,骨节酸痛,腹痛泄泻,肠风下血,破伤中风,麻疹难透,风疹瘙痒,疮疡初起。
五味子:味甘、酸,性温。能益气生津,补肾养心,收敛固涩。用于气虚津伤,体倦多汗,短气心悸;肺气不足或肺肾两虚所致的喘咳,或喘咳日久,肺气耗伤;心阴不足,心悸怔忡,失眠健忘;肾气不固,遗精,尿频,或脾肾两虚。
菟丝子:滋补肝肾,安胎,明目,止泻。用于:阳痿遗精,尿有余沥,遗尿尿频,药膝酸软,目昏耳鸣,肾虚胎漏,胎动不安,脾肾虚泻。
细辛:祛风,散寒,行水,开窍。治风冷头痛,鼻渊,齿痛,痰饮咳逆,风湿痹痛。宜通肺窍:用于鼻炎、鼻窦炎
茜草:苦,寒。归肝经。有凉血止血,化瘀,通经的作用。主治血热吐衄,崩漏下血,血瘀经闭,跌打损伤,风湿痹痛。由于茜草有活血通经的作用,临床上常用来治疗风湿痹痛。
豨签草:祛除风湿,强健筋骨,清热解毒。治四肢麻痹,筋骨疼痛,腰膝无力,疟疾,急性肝炎,高血压病,疔疮肿毒,外伤出血。
蝉蜕:蝉蜕可以散风除热,利咽,透疹,退翳,解痉。用于风热感冒,咽痛,音哑,麻疹不透,风疹瘙痒,目赤翳障,惊风抽搐,破伤风。
乌梅:味酸、微涩,性平。归肝、脾、肺、胃、大肠经。质润敛涩。敛肺,涩肠,生津,安蛔。用于肺虚久咳,久痢滑肠,虚热消渴,蛔厥呕吐腹痛,胆道蛔虫症。
地龙:地龙性寒,味咸。功能:清热、平肝、止喘、通络。归肝、胃、肺、膀胱经。功能清热平肝、熄风止痉、平喘、利尿、通络除痹。主治高热烦躁、惊痫抽搐、肺热喘咳、热结尿闭、痹痛肢麻、半身不遂,以及疮疡肿毒等证。主治高热狂燥,惊风抽搐,风热头痛,目赤、半身不遂等。地龙提供取液有良好的定咳平喘的作用。
旱莲草:滋补肝肾,乌须固齿,凉血止血。 主治:肝肾不足,眩晕耳鸣,视物昏花,腰膝酸软,发白齿摇,劳淋带浊,咯血,吐血,衄血,尿血,血痢,崩漏,外伤出血。
浮小麦:性味甘、凉,入心经,有益气除热,养心生津,止虚汗、盗汗,骨蒸虚热的作用,用于治疗虚热多汗、盗汗、口干舌燥、心烦失眠。
甘草:甘草性平,味甘,归十二经。有解毒、祛痰、止痛、解痉以至抗癌等药理作用。在中医上,甘草补脾益气,滋咳润肺,缓急解毒,调和百药。
过敏性鼻炎中医属于“鼻渊”,是因邪犯鼻窦,窦内湿热蕴积,酿成痰浊所致,以鼻流浊涕量多为特征的鼻病。证候分类为肺经风热、胆经郁热、脾胃湿热、肺脾气虚。本发明应用黄芪、白术、防风、五味子、甘草益气固表,主要对过敏性鼻炎的肺脾气虚治疗。菟丝子、浮小麦、旱莲草滋补肝肾固表。地龙、蝉蜕清热平肝、散风除热,主要对过敏性鼻炎的胆经郁热治疗。豨签草、细辛配合蝉蜕主要对过敏性鼻炎的肺经风热治疗。细辛、茜草、乌梅敛肺涕,活血通经,针对过敏性鼻炎的鼻粘膜长期充血治疗。君、臣、佐、使各施其效,疗效显著。
本发明采用以上技术方案,与现有技术相比,具有以下优点:购买方便,价格便宜,原材料各组分配比例合理,作用互补,有机配伍,本发明君、臣、佐、使各施其效,具有用药少,见效快,临床观察证实无毒副作用,可达到标本兼顾的目的,治疗效果好,无化学药物的毒副作用,可长期服用。
具体实施方式
下面结合实施例对本发明作进一步说明。
实施例1:一种用于治疗过敏性鼻炎的中药组合物,由以下重量份的原材料制成:
黄芪30份、白术15份、防风10份、五味子10份、菟丝子15份、细辛3份、茜草15份、豨签草15份、蝉蜕15份、乌梅15份、地龙15份、旱莲草15份、浮小麦15份、甘草10份。
制备方法,包括以下步骤:
a、将黄芪、白术、防风、五味子、菟丝子、细辛、茜草、豨签草、蝉蜕、乌梅、地龙、旱莲草、浮小麦、甘草一起混合,加水煎煮两次,滤过,合并滤液,浓缩至滤液体积的1/2,得浓缩液;
b、将步骤a所得的浓缩液浓缩至相对密度80℃测得1.20~1.24的稠浸膏;
c、将上述步骤b的稠浸膏混合均匀后移进烘箱,50-70℃烘干至水分低于5%,加入辅料按现有技术制成散剂。
实施例2:一种用于治疗过敏性鼻炎的中药组合物,由以下重量份的原材料制成:。
黄芪60份,白术30份,防风20份,五味子20份,菟丝子30份,细辛6份,茜草20份,豨签草30份,蝉蜕20份,乌梅20份,地龙30份,旱莲草30份,浮小麦30份,甘草20份。
制备方法同实施例1。
实施例3:一种用于治疗过敏性鼻炎的中药组合物,由以下重量份的原材料制成:
黄芪15份、白术8份、防风6份、五味子6份、菟丝子8份、细辛2份、茜草8份、豨签草8份、蝉蜕8份、乌梅8份、地龙8份、旱莲草8份、浮小麦8份、甘草6份。
制备方法同实施例1。
对比试验:
疗效标准:依据<<中医耳鼻喉科病证诊断疗效标准>>中治疗“鼻渊”的疗效判定标准:
疗效评定:
治愈:症状消失,X线鼻窦片无异常。
好转:症状明显改善,鼻腔检查见充血、粘膜肿胀等表现减轻。X线鼻窦摄片有明显改善。
未愈:症状和体征无改善。
选取200例的过敏性鼻炎患者,随机选取150例作为治疗组,另外50例作为对照组,其中150例患者分为治疗组1、治疗组2和治疗组3,每个治疗组治疗随机选取的50例患者,治疗组1使用本发明实施例1制备的散剂进行治疗,治疗组2使用本发明实施例2制备的散剂进行治疗,治疗组3使用本发明实施例3制备的散剂进行治疗。对照组应用鼻炎康治疗。一个月为1疗程。
治疗结果如下表:
从以上数据表可以看出,治疗组有效率治愈率明显高于对照组, 治疗组1和2的治愈率有效率高于其余治疗组,综上所述治疗组1和2组方最为有效。
Claims (3)
1.一种治疗过敏性鼻炎的中药组合物,其特征是:所述中药组合物由以下重量份的原材料制成:
黄芪1-60份、白术1-30份、防风1-20份、五味子1-20份、菟丝子1-30份、细辛1-6份、茜草1-20份、豨签草1-30份、蝉蜕1-20份、乌梅1-20份、地龙1-30份、旱莲草1-30份、浮小麦1-30份、甘草1-20份。
2.如权利要求1所述治疗过敏性鼻炎的中药组合物,其特征是:所述中药组合物由以下重量份的原材料制成:
黄芪30份、白术15份、防风10份、五味子10份、菟丝子15份、细辛3份、茜草15份、豨签草15份、蝉蜕15份、乌梅15份、地龙15份、旱莲草15份、浮小麦15份、甘草10份。
3.如权利要求1或2所述治疗过敏性鼻炎的中药组合物制剂的制备方法,其特征是:所述制备方法包括以下步骤:
a、将黄芪、白术、防风、五味子、菟丝子、细辛、茜草、豨签草、蝉蜕、乌梅、地龙、旱莲草、浮小麦、甘草一起混合,加水煎煮两次,滤过,合并滤液,浓缩至滤液体积的1/2,得浓缩液;
b、将步骤a所得的浓缩液浓缩至相对密度80℃测得1.20~1.24的稠浸膏;
c、将上述步骤b的稠浸膏混合均匀后移进烘箱,50-70℃烘干至水分低于5%,加入辅料按现有技术制成散剂、胶囊剂、片剂、颗粒剂或丸剂。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610572459.8A CN105943940A (zh) | 2016-07-20 | 2016-07-20 | 一种用于治疗过敏性鼻炎的中药组合物及其制剂的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610572459.8A CN105943940A (zh) | 2016-07-20 | 2016-07-20 | 一种用于治疗过敏性鼻炎的中药组合物及其制剂的制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105943940A true CN105943940A (zh) | 2016-09-21 |
Family
ID=56901198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610572459.8A Withdrawn CN105943940A (zh) | 2016-07-20 | 2016-07-20 | 一种用于治疗过敏性鼻炎的中药组合物及其制剂的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105943940A (zh) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1751730A (zh) * | 2004-09-20 | 2006-03-29 | 曹蛟 | 一种治疗过敏性鼻炎的中药及其制备方法 |
CN1872280A (zh) * | 2005-05-30 | 2006-12-06 | 成都华神集团股份有限公司制药厂 | 一种治疗过敏性鼻炎的中药组合物及其制备方法 |
CN101537089A (zh) * | 2008-03-21 | 2009-09-23 | 北京中泰天和科技有限公司 | 一种治疗过敏性鼻炎的药物组合及其制备方法 |
CN101637562A (zh) * | 2009-09-14 | 2010-02-03 | 黄山 | 一种过敏性鼻炎颗粒 |
CN102283916A (zh) * | 2011-08-03 | 2011-12-21 | 郭芝萍 | 一种治疗过敏性鼻炎的药物及其制备方法 |
CN103432475A (zh) * | 2013-09-06 | 2013-12-11 | 梁怡芃 | 一种治疗过敏性鼻炎的中药组合物及其制备方法 |
CN105031588A (zh) * | 2015-08-18 | 2015-11-11 | 康明 | 一种治疗鼻炎的中药及其制备方法 |
-
2016
- 2016-07-20 CN CN201610572459.8A patent/CN105943940A/zh not_active Withdrawn
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1751730A (zh) * | 2004-09-20 | 2006-03-29 | 曹蛟 | 一种治疗过敏性鼻炎的中药及其制备方法 |
CN1872280A (zh) * | 2005-05-30 | 2006-12-06 | 成都华神集团股份有限公司制药厂 | 一种治疗过敏性鼻炎的中药组合物及其制备方法 |
CN101537089A (zh) * | 2008-03-21 | 2009-09-23 | 北京中泰天和科技有限公司 | 一种治疗过敏性鼻炎的药物组合及其制备方法 |
CN101637562A (zh) * | 2009-09-14 | 2010-02-03 | 黄山 | 一种过敏性鼻炎颗粒 |
CN102283916A (zh) * | 2011-08-03 | 2011-12-21 | 郭芝萍 | 一种治疗过敏性鼻炎的药物及其制备方法 |
CN103432475A (zh) * | 2013-09-06 | 2013-12-11 | 梁怡芃 | 一种治疗过敏性鼻炎的中药组合物及其制备方法 |
CN105031588A (zh) * | 2015-08-18 | 2015-11-11 | 康明 | 一种治疗鼻炎的中药及其制备方法 |
Non-Patent Citations (1)
Title |
---|
吴复苍,阚湘苓: "《常见病遣方用药规律》", 31 October 2015, 人民军医出版社 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN106267120A (zh) | 一种治疗鼻炎的中药制剂及其制备方法 | |
CN103432559B (zh) | 一种治疗血滞型月经减少及痛经的中药组合物及其制备方法和用途 | |
CN103638451A (zh) | 一种治疗慢性肝炎的中药及其制备方法 | |
CN107737288B (zh) | 一种治疗过敏性哮喘的中药组合物及其制备方法 | |
CN104771578A (zh) | 用于治疗变应性鼻炎的中药 | |
CN104587206A (zh) | 治疗褥疮的药物及制备方法 | |
CN101690797B (zh) | 一种治疗风湿、类风湿疾病的中药 | |
CN103720980A (zh) | 一种治疗慢性肾炎的药物 | |
CN105770691A (zh) | 一种用于治疗***的药物制剂及其用途 | |
CN105106508A (zh) | 苍耳子过敏性鼻炎膏 | |
CN105362682A (zh) | 一种治疗月经过少的外用药物 | |
CN100411681C (zh) | 缩短坐月子时间及治疗人流后遗症产后风的药物 | |
CN104306872A (zh) | 一种治疗子宫肌瘤的中药 | |
CN104288581A (zh) | 用于治疗先兆流产的中药 | |
CN104306847A (zh) | 一种六味补气胶囊及其制备工艺 | |
CN105943940A (zh) | 一种用于治疗过敏性鼻炎的中药组合物及其制剂的制备方法 | |
CN103610772A (zh) | 治疗脑血栓的中药 | |
CN102357179B (zh) | 治疗抗***抗体致***症或习惯性流产的药物及制备方法 | |
CN105726823A (zh) | 一种治疗过敏性鼻炎的中药制剂及其制备方法 | |
CN105998512A (zh) | 一种治疗股骨干骨折的药物组合物及制备方法 | |
CN105250618A (zh) | 一种治疗肝硬化的抗病毒中药组合物及其制备方法 | |
CN105327299A (zh) | 一种用于治疗原发性血小板减少紫癜的药物 | |
CN104922595A (zh) | 一种用于带状疱疹的中药制剂及其制备方法 | |
CN105169111A (zh) | 一种用于治疗慢性荨麻疹的中药组合物及其应用 | |
CN104644955B (zh) | 一种治疗痛经的中药组合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160921 |
|
WW01 | Invention patent application withdrawn after publication |