CN105106754A - Dietary therapy anticancer preparation and preparation method thereof - Google Patents
Dietary therapy anticancer preparation and preparation method thereof Download PDFInfo
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- CN105106754A CN105106754A CN201510589422.1A CN201510589422A CN105106754A CN 105106754 A CN105106754 A CN 105106754A CN 201510589422 A CN201510589422 A CN 201510589422A CN 105106754 A CN105106754 A CN 105106754A
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Landscapes
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Abstract
The invention discloses a dietary therapy anticancer preparation which comprises, by weight parts, 2-6 parts of ganoderma lucidum, 2-6 parts of lentinula edodes, 3-7 parts of dandelion, 1-5 parts of asparagus, 2-7 parts of soybean, 1-5 parts of sea buckthorn, 2-4 parts of tomato, 2-5 parts of carrot, 3-7 parts of pearl barley and 2-6 parts of jujube. Through plenty of research and dialectics, based on the composition principle of monarch drugs, minister drugs, adjuvant drugs and envoy drugs, the raw materials are scientifically matched, interact and prevent and treat various cancers, and the raw materials in use are 100% pure natural food materials and have no toxic or side effect. The raw materials undergo optimal proportion tests, the optimal matching proportions of the raw materials are determined, contained nutritional ingredients are rich and balanced, it begins from improvement of immunity, killing of cancer cells and cutting off of nutrition supply of cancer cells, functions of the organism in various aspects are affected by utilizing dietary therapy, and various cancers are effectively treated and prevented. The invention further discloses a method for preparing the preparation.
Description
Technical field
The present invention relates to dietetic therapy anti-cancer field, particularly a kind of dietetic therapy anticancer preparation and preparation method thereof.
Background technology
Along with the progress of the reach of science, medical science, the understanding of people to disease is more and more clearer.As everyone knows, cancer seriously threatens the health of the mankind, and the method for beat cancer is also maked rapid progress, at in the past intrinsic operative treatment, chemotherapy, outside the large conventional treatment of radiotherapy three, there is again molecular targeted therapy, Biotherapeutics, immunization therapy, endocrine therapy, Chinese traditional treatment, the multiple therapy methods such as therapy of combining Chinese and Western medicine, wherein the feature of Chinese traditional treatment is from entirety, implement determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, to yin asthenia generating intrinsic heat person Yin-nourishing and body fluid promoting, to deficiency of YANG QI, person works as warming YANG and invigorating QI, to the easypro person's soothing liver-QI for relieving depression of feelings will, after treatment basic scheme is clear and definite, in conjunction with the clinical concrete condition of patient, the side's of sending medication, kill cancerous cell, this treatment must aim at the pathogenesis of disease, the treatment ment for the treatment of both the principal and secondary aspects of a disease is the anticancer advantage of the traditional Chinese medical science.
Integration of edible and medicinal herbs, various bioactive substance is had in numerous food product, therefore, dietotherapy becomes the important composition part of Chinese therapeutics, and the successive dynasties, outstanding doctor took much count of dietetic therapy, as by honor being Eastern Han Dynasty's Zhang Zhongjing of doctor sage, after the king of medicine grandfather of China, the Tang Dynasty Sun Simiao propose " a dietetic therapy section " in its Thousand Golden Prescriptions, the successive dynasties, well-known doctor attached great importance to dietetic therapy, particularly founding of New, dietetic therapy development is more rapid, and various dietetic therapy book occurs a lot.Dietetic therapy is as the anticancer branch of the traditional Chinese medical science, evident in efficacy, safely, have no side effect, simultaneously because of its have simply, facilitate, valency is held concurrently, effective feature obtains swift and violent development especially.The anticancer kind of present dietetic therapy is increasing, but it exists following shortcoming mostly: (1) only for a certain class cancer patients effective, can not to kinds cancer onset simultaneously, thus use there is certain limitation; (2) in raw material or adjuvant, some drugs composition is non-pure natural food materials, has larger side effect.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of double dietetic therapy anticancer preparation and preparation method thereof controlling kinds cancer, evident in efficacy, safe without toxic side effect.
In order to solve above-described technical problem, the present invention by the following technical solutions:
A kind of dietetic therapy anticancer preparation, the crude drug making effective ingredient is made up of following parts by weight:
Ganoderma 2 ~ 6 parts, 2 ~ 6 parts, Lentinus Edodes, Herba Taraxaci 3 ~ 7 parts, Germinatus Phragmitis 1 ~ 5 part, Semen sojae atricolor 2 ~ 7 parts, Fructus Hippophae 1 ~ 5 part, Fructus Lycopersici esculenti 2 ~ 4 parts, 2 ~ 5 parts, Radix Dauci Sativae, Semen Coicis 3 ~ 7 parts, 2 ~ 6 parts, Fructus Jujubae.
Further, the crude drug making effective ingredient is made up of following parts by weight: Ganoderma 4 parts, 4 parts, Lentinus Edodes, Herba Taraxaci 5 parts, Germinatus Phragmitis 3 parts, Semen sojae atricolor 5 parts, Fructus Hippophae 4 parts, Fructus Lycopersici esculenti 3 parts, 4 parts, Radix Dauci Sativae, Semen Coicis 5 parts, 4 parts, Fructus Jujubae.
Described dietetic therapy anticancer preparation is the peroral dosage form on pharmaceutics.
Described dietetic therapy anticancer preparation is oral liquid or water-honeyed pill or tablet or capsule.
A preparation method for described dietetic therapy anticancer preparation, comprises the following steps:
Described Ganoderma, Lentinus Edodes, Herba Taraxaci, Germinatus Phragmitis, Semen sojae atricolor, Fructus Hippophae, Fructus Lycopersici esculenti, Radix Dauci Sativae, Semen Coicis and Fructus Jujubae take by weight, mixing remove impurity, and dry at cleaning is placed on 50 ~ 60 DEG C, after co-grinding, 100 orders sieve and obtain raw material mixing fine powders;
Heat 30 ~ 40min at Mel being placed in 40 ~ 45 DEG C, 60 mesh filter screen coarse filtration, 100 mesh filter screen fine filterings, obtain refined honey;
Mixed homogeneously with weight ratio 1:0.4 ~ 4 with gained refined honey by the raw material mixing fine powders of gained, be incubated 30 ~ 40min at 30 ~ 40 DEG C, after naturally cooling to room temperature, kneading is processed and is obtained water-honeyed pill.
Further, described in the preparation method of described dietetic therapy anticancer preparation, the weight ratio of raw material mixing fine powders and refined honey is 1:1 ~ 1.5.
To adopted ten kinds of food materials brief introductions:
1, Ganoderma is the dry entity of the red spirit of On Polyporaceae, purple spirit, is traditional good merchantable brand that broad masses like, records according in " Chinese medicine voluminous dictionary " second edition: property is sweet, flat, GUIXIN, lung, liver, kidney channel; There is invigorating QI and tranquilization, the effect of relieving cough and asthma, for dizzy sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.Modern study shows that the compound such as ganoderan and Ganoderma three note class wherein contained has function and blood fat reducing, blood sugar lowering and the cancer-resisting curative effect of enhancing human body immunity power.
2, Lentinus Edodes is Agaricales, Kou Mo section plant, the entity of Lentinus Edodes, its delicious flavour, and nutritious, contained lentinan, various nutrients have anti-cancer and kill cancer action.
3, Herba Taraxaci is the dry herb of Compositae platymiscium.Its main component has taraxasterol, taraxacin, taraxacin, Taraxacum Polysaccharides, Long-term Clinical Observation and many experiments find, Taraxacum Polysaccharides can improve and improve mouse cell immunity, Promote immunity cell proliferation, promotes the recovery damaged by the immune function of mice of caused by cyclophosphamide significantly.Also find that the total flavones contained by Herba Taraxaci can remove ultra-oxygen anion free radical effectively, suppresses the oxidation of unsaturated fatty acid, alleviates body oxidative damage.
4, Germinatus Phragmitis is liliaceous plant, containing anti-cancer principle such as dietary fiber, bata-carotene, vitamin C, potassium, calcium, selenium, normal cell canceration can not only be prevented, and the cell of canceration can also be made to be inhibited, improve immunity of organism, anticancer is bred.
5, Fructus Jujubae is the fruit of Rhamnaceae plant-Fructus Jujubae, contained active polysaccharide composition, particularly contained triterpenoid compound and cycli phosphate glycosides antitumaous effect more outstanding, the existing great attention having caused Chinese and foreign department scholar.
6, Semen Glycines is the amber seed of leguminous plant-Semen sojae atricolor, also Semen sojae atricolor is claimed, nutritious, there is the laudatory title of Vegetable meat, interior soybean protein-containing, dietary fiber, soybean isoflavone, vitamin B complex, linoleic acid, linolenic acid etc., soybean isoflavone wherein has and strengthens immunity and anti-cancer, the effect such as anticancer.
7, Semen Coicis is the kernel of grass-Semen Coicis, also known as Semen Coicis, Semen Coicis etc.The compositions such as contained Semen Coicis polysaccharide, dietary fiber, vitamin, Coixenolide, effective in cure to cervical cancer, breast carcinoma, ovarian cancer, cancer of pancreas etc.
8, the root of Radix Dauci Sativae Shi San section kind of plant-Radix Dauci Sativae, also claims Radix Dauci Sativae, and containing carotene, protein, vitamin B1, B2, E, terpenoid, sterol, ferrum, potassium, calcium, selenium and several amino acids, anticancer therapeutic is remarkable.Carotene wherein can be used for skin carcinoma, pulmonary carcinoma, esophageal carcinoma, gastric cancer, colon cancer, bladder cancer, breast carcinoma, uterus carcinoma etc.
9, Fructus Lycopersici esculenti is the fruit of plant of Solanaceae-Fructus Lycopersici esculenti, and clinical research finds that Fructus Lycopersici esculenti element contained in Fructus Lycopersici esculenti has inhibitory action to multiple cancerous cell, in addition, also finds that Fructus Lycopersici esculenti element safeguards the normal a kind of material of cell.
10, Fructus Hippophae is the fruit of Elaeangnaceae plant-Fructus Hippophae, in clinical practice, finds that its composition contains carotene, cellulose, vitamin B
1, B
2, C, E flavonoid, folic acid, sitosterol, and the multiple anticancer component such as mineral, calcium, ferrum, magnesium, many experiments shows: can promote Splenic vein hemodynamics, obvious enhancing abdominal cavity phagocytic function, enhancing human body immunity power, meanwhile, Oleum Hippophae is also rich in essential fatty acid and other bioactive substance, and anthocyanidin etc. has anti-cancer and kill cancer action.
The present invention's 10 kinds of raw materials 100% used are pure natural food materials, its all effect is by strengthening immunity, suppress or kill cancerous cell, or malnutrition is implemented to cancerous cell thus anticancer propagation for anticancer means, thus reach the therapeutic purposes eliminating cancerous cell.
Li Shizhen (1518-1593 A.D.) was once said: " drink trencherman, the lifeblood of people also ", and common saying is also said: " Diet cures more than the doctors, and medication is not as dietetic therapy ".Huangdi's Internal Classics has cloud: " supporting vital QI with five kinds of grains, assisting vital QI with five kinds of fruits, reinforcing vital QI with meats of five livestock, supplementing vital QI with five kinds of veg etables, taking the mixed foods of various natures and flavors; with replenishing vital essence and invigorating vital QI ", and the present invention filters out raw material used from hundreds of pure natural plant, utilizes food to affect the function of body each side, prophylaxis of cancer, Therapeutic cancer.
The present invention can prevent and treat the anticancer composition of kinds cancer and mechanism as follows: the main component contained by the present invention has polysaccharide, triterpenes, flavonoid, compound, in addition, also has Crataegolic acid, cycli phosphate gland is sweet, Coixenolide, vitamins, multiple Fructus Hippophae acid, anthocyanidin isoreactivity material and potassium, calcium, ferrum, magnesium, the anticancer components such as selenium, these natural plant active components and other various nutrients, compatibility is carried out by the principle of traditional Chinese medical science monarch prescription, and based on determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, (hope with the four diagnostic methods, hear, ask, cut), the eight guiding principles for diagnosis (negative and positive the exterior and the interior cold and heat and asthenia and sthenia) are for instructing, science permutation and combination is carried out to various food materials, thus play drug action better.By immunomodulating, strengthen cancer friend body resistance against diseases, finally reach and suppress or kill cancerous cell, alleviate cancer friend symptom, so beat cancer.
Dietetic therapy anticancer preparation of the present invention for main component with the Herba Taraxaci of described various effect, Ganoderma, Lentinus Edodes, Semen sojae atricolor, Fructus Hippophae, Fructus Lycopersici esculenti, Radix Dauci Sativae, Semen Coicis, Germinatus Phragmitis and Fructus Jujubae, can be mixed Mel and make water-honeyed pill.The whole dietetic therapy anticancer preparation traditional Chinese medical science selects the principle of medicine prescription, by the property of medicine " monarch, minister, help, make " principle prescription.Unit medicine is formed a kind of prescription, according to the needs of the state of an illness, on the basis of dialectical legislation, select suitable drug regimen to form, ancient title " monarch " is not simply pile up together by medicine, it proposes already in "Nei Jing": " the meaning monarch of main disease; the drug in a prescription helping monarch-drug is called miniSter, answer minister for making ", principal and subordinate's principle of medication in the principle of system side and prescription is described with this.
Monarch drug is for the cause of disease and main symptom, is the medicine played a major role, and the monarch drug in the present invention is the Ganoderma of the kidney invigorating, Lentinus Edodes, Herba Taraxaci.Ganoderma records according to " Chinese medicine voluminous dictionary " second edition the activity that experimental result display Ganoderma has superoxides Qihoo dismutase, and the peroxidating of ganoderan to the generation of ultra-oxygen anion free radical and erythrocyte lipid has inhibitory action.Lentinus Edodes, Herba Taraxaci have raising immunity of organisms, anticancer effect, and the ganoderan in Ganoderma, while suppressing cancer, can treat the leukopenia caused by chemotherapy; Lentinus Edodes contains lentinan energy activating macrophage vigor, improves immunity of organisms, and after unsaturated fatty acid contained in Lentinus Edodes kills cancerous cell, the ergosterol in Lentinus Edodes can transform vitamin after absorption of human body, further anticancer proliferation and spreading.The total flavones contained in Herba Taraxaci can suppress the oxidation of unsaturated fatty acid, alleviate the oxidative damage of body, promote body's immunity, taraxasterol, taraxacin, taraxacin, Taraxacum Polysaccharides, can not only Promote immunity cell proliferation, and can the damaged cell of repair function.Also show through results of animal: Herba Taraxaci hot water extract to inoculation mice ehrlich carcinoma and MM46 tumor cell all inhibited, the methanolic extract of Radix Taraxaci and water extract have inhibitory action to DMBA (DMBA) and phorbol exters (TPA) induced mice cutaneous papilloma, not only can impel immune cell propagation, and can the damaged cell of repair function.Cooperatively interact between Ganoderma, Lentinus Edodes, Herba Taraxaci three, following triple role can be played: the generation 1, improving body immune function prophylaxis of cancer, 2, improve body immune machine to assist further to kill cancerous cell, 3, the oxidative damage of health body is alleviated, increase the recovery of human normal quantity of leucocyte, simultaneously the damaged cell of repair function.Ganoderma, Lentinus Edodes, Herba Taraxaci three with the use of, emphasize particularly on different fields from the mechanism of anti-cancer and cancer-preventing, mutually collaboratively to supplement, also can treat the leukopenia caused by chemotherapy; Fundamentally reach the effect of prevention, treatment, rehabilitation, there is any component and be used alone the effect unique all do not had.
Ministerial drug is medicine or the double sick medicine for the treatment of that auxiliary monarch drug strengthens therapeutical effect, and Germinatus Phragmitis, Semen Glycines and Semen Coicis are ministerial drugs in the present invention.Agedoite contained by Germinatus Phragmitis prevents normal cell canceration, makes the cell generation malnutrition through canceration, thus anticancer is bred further; Contained by Germinatus Phragmitis, bata-carotene, vitamin C and selenium etc., have effective antioxidation, thus strengthen the antitumaous effect of monarch drug; Protein contained by Semen Glycines, dietary fiber, linoleic acid, linolenic acid are all that the isoflavone particularly contained by it all has inhibitory action to gastric cancer, hepatocarcinoma, pulmonary carcinoma, bladder cancer, colon cancer, carcinoma of prostate, osteocarcinoma and leukemia to the necessary important nutrient of people; In Semen Coicis, contained Coixenolide can be bred by anticancer, and unsaturated fatty acid contained in Semen Coicis also has enhancing immunologic function, also plays potentiation further to monarch drug.
The double medicine controlling other disease of monarch drug assisted by adjuvant drug, and Fructus Hippophae, Radix Dauci Sativae, Fructus Lycopersici esculenti are adjuvant drugs in the present invention.Fructus Hippophae: total flavones has the activity improving free radical scavenging enzyme, anti-lipid peroxidation reacts, enhancing human body immunity power, and hippophae rhamnoides nutrition is comprehensive, contained carotene, cellulose, vitamin B
1, B
2, the anticancer component such as injection Vitamin B_6 flavonoid and calcium, ferrum, magnesium, of some help to reinforcement monarch drug.In Radix Dauci Sativae, contained carotene is a kind of well antioxidant, can scavenging free radicals, strengthens immunoreation, blocks the formation of carcinogenic active substance, can also inducing cancer cell differentiation, and anticancer is bred.Fructus Lycopersici esculenti element contained in Fructus Lycopersici esculenti has anti-oxidation efficacy, can also repair impaired cell.
Make medicine be guiding drug or coordinating the actions of various ingredients in a prescription, make between various raw material through science collocation interact obvious component, make medicine be Fructus Jujubae in the present invention.The invigorating the spleen and replenishing QI of Fructus Jujubae function, nourishing blood to tranquillize the mind, coordinating the actions of various ingredients in a prescription, Fructus Jujubae has the effect improving Chinese medicine mouthfeel simultaneously.
Mel sweet in the mouth, property are flat, enter lung, spleen, large intestine channel; Adjustable gastric intestinal tract disease, natural honey can prevent the mouse Gastric Diseases by Spraying of alcohol-induced, can increase mouse vascular permeability, and prevent the gastric mucosal lesions of anoxia-Reperfu-sion-bring out, determine at present, natural honey has the effect of protection stomach, and has oxidation resistance; In addition, Mel has defecating feces excretion, and this is relevant with the incomplete absorption of fructose; Mel also have nutrition, antibacterial, promote wound healing and immunization.Mel, as auxiliary material conventional in pharmacy procedure, simultaneously in Chinese medicine and dietetic therapy field, also has the effect having and improve Chinese medicine mouthfeel.
Dialectical by large quantifier elimination, based on " monarch, minister, help, the make " principles of formulating prescriptions, arrange in pairs or groups through science between the various raw materials that the property of medicine is different, interact, curative effect strengthens, thus reaches the object of prophylactic treatment kinds cancer, clinical effectiveness is obvious, the present invention raw materials used 100% is the safety of pure natural food materials, use, does not produce toxic and side effects.The present invention has carried out optimization test to its each material simultaneously, determine the optimal proportion of each material in component, contained rich in nutrition content, equilibrium, start with from nutrition supply three aspect improving immunity, kill cancerous cell and block cancerous cell, utilize dietetic therapy to affect the function of body each side, effectively treatment and prevention kinds cancer.
Detailed description of the invention
Embodiment 1
This enforcement provides a kind of dietetic therapy anticancer preparation, and the raw material making active ingredient is made up of following parts by weight;
Ganoderma 2 parts, 2 parts, Lentinus Edodes, Herba Taraxaci 3 parts, Germinatus Phragmitis 1 part, Semen sojae atricolor 2 parts, Fructus Hippophae 1 part, Fructus Lycopersici esculenti 2 parts, 2 parts, Radix Dauci Sativae, Semen Coicis 3 parts, 2 parts, Fructus Jujubae.
The present embodiment additionally provides the preparation method of above-mentioned dietetic therapy anticancer preparation (water-honeyed pill), and step is as follows:
Step one: take Ganoderma, Lentinus Edodes, Herba Taraxaci, Germinatus Phragmitis, Semen sojae atricolor, Fructus Hippophae, Fructus Lycopersici esculenti, Radix Dauci Sativae, Semen Coicis and Fructus Jujubae by weight portion in above-mentioned formula, mixing remove impurity, dry at cleaning is placed on 55 DEG C, after co-grinding, 100 orders sieve and obtain raw material mixing fine powders.
Step 2: heat 30min at fresh honey is placed in 40 DEG C, 60 mesh filter screen coarse filtration, 100 mesh filter screen fine filterings obtain refined honey.
Step 3: above-mentioned raw materials mixing fine powders and refined honey are mixed with 1:1 weight, be incubated 40min at 30 DEG C, after naturally cooling to room temperature, water-honeyed pill is processed in kneading, every ball 10g.
Composition analyzed
Effect detection for dietetic therapy anticancer preparation is divided into 4 grades: 1) cure: cancerous cell disappears completely, feel without uncomfortable, the indagation of the traditional Chinese medical science four methods of diagnosis is normal, the medical imaging such as B ultrasonic, nuclear-magnetism checks that whole body is without tumor, cancer laboratory indexes is normal, and lymphocyte subgroup amynologic index recovers normal; 2) effective (remarkable result): symptom obviously alleviates, and focus obviously diminishes, life, quality of life improves; 3) effective: symptom is eased; 4) invalid.
The present embodiment selects 100 cases of various cancers from internal clinic, and carry out system clinical observation, period withdraws all medicines, only takes embodiment medicine; Observation period is six months (each moon is a course for the treatment of), observes six months altogether; Method of administration: 10g (every ball)/time, take 2 day, ante cibum, light salt brine took, and its experimental result is as table 1 (data are all in units of people).
Embodiment 2
Present embodiments provide a kind of dietetic therapy anticancer preparation, the raw material making active ingredient is made up of following parts by weight:
Ganoderma 3 parts, 3 parts, Lentinus Edodes, Herba Taraxaci 4 parts, Germinatus Phragmitis 4 parts, Semen sojae atricolor 4 parts, Fructus Hippophae 2 parts, Fructus Lycopersici esculenti 3 parts, 3 parts, Radix Dauci Sativae, Semen Coicis 4 parts, 3 parts, Fructus Jujubae.
The present embodiment additionally provides the preparation method of above-mentioned dietetic therapy anticancer preparation (water-honeyed pill), and step is as follows:
Step one: take Ganoderma, Lentinus Edodes, Herba Taraxaci, Germinatus Phragmitis, Semen sojae atricolor, Fructus Hippophae, Fructus Lycopersici esculenti, Radix Dauci Sativae, Semen Coicis and Fructus Jujubae by weight portion in above-mentioned formula, mixing remove impurity, dry at cleaning is placed on 50 DEG C, after co-grinding, 100 orders sieve and obtain raw material mixing fine powders.
Step 2: heat 30min at fresh honey is placed in 45 DEG C, 60 mesh filter screen coarse filtration, 100 mesh filter screen fine filterings obtain refined honey.
Step 3: above-mentioned raw materials mixing fine powders and refined honey are mixed with 1:0.44 weight, be incubated 30min at 40 DEG C, after naturally cooling to room temperature, water-honeyed pill is processed in kneading, every ball 10g.
Patient 100 example that the present embodiment also selects the medical history state of an illness, age and sex suitable with embodiment 1, detection method is with embodiment 1, and its experimental result is as shown in table 1.
Embodiment 3
This enforcement provides the raw material that a kind of dietetic therapy anticancer preparation makes active ingredient and is made up of following parts by weight: Ganoderma 4 parts, 4 parts, Lentinus Edodes, Herba Taraxaci 5 parts, Germinatus Phragmitis 3 parts, Semen sojae atricolor 5 parts, Fructus Hippophae 4 parts, Fructus Lycopersici esculenti 3 parts, 4 parts, Radix Dauci Sativae, Semen Coicis 5 parts, 4 parts, Fructus Jujubae.
The present embodiment additionally provides the preparation method of above-mentioned dietetic therapy anticancer preparation (water-honeyed pill), and step is as follows:
Step one: take Ganoderma, Lentinus Edodes, Herba Taraxaci, Germinatus Phragmitis, Semen sojae atricolor, Fructus Hippophae, Fructus Lycopersici esculenti, Radix Dauci Sativae, Semen Coicis and Fructus Jujubae by weight portion in above-mentioned formula, mixing remove impurity, dry at cleaning is placed on 60 DEG C, after co-grinding, 100 orders sieve and obtain raw material mixing fine powders.
Step 2: heat 40min at fresh honey is placed in 40 DEG C, 60 mesh filter screen coarse filtration, 100 mesh filter screen fine filterings obtain refined honey.
Step 3: above-mentioned raw materials mixing fine powders and refined honey are mixed with 1:4 weight, be incubated 35min at 35 DEG C, after naturally cooling to room temperature, water-honeyed pill is processed in kneading, every ball 10g.
Patient 100 example that the present embodiment also selects the medical history state of an illness, age and sex suitable with embodiment 1, detection method is with embodiment 1, and its experimental result is as shown in table 1.
Embodiment 4
Present embodiments provide a kind of dietetic therapy anticancer preparation to make active ingredient raw material and be made up of following parts by weight:
Ganoderma 4 parts, 3 parts, Lentinus Edodes, Herba Taraxaci 5 parts, Germinatus Phragmitis 4 parts, Semen sojae atricolor 6 parts, Fructus Hippophae 2 parts, Fructus Lycopersici esculenti 4 parts, 3 parts, Radix Dauci Sativae, Semen Coicis 3 parts, 3 parts, Fructus Jujubae.
The present embodiment additionally provides the preparation method of above-mentioned dietetic therapy anticancer preparation (water-honeyed pill), and step is as follows:
Step one: take Ganoderma, Lentinus Edodes, Herba Taraxaci, Germinatus Phragmitis, Semen sojae atricolor, Fructus Hippophae, Fructus Lycopersici esculenti, Radix Dauci Sativae, Semen Coicis and Fructus Jujubae by weight portion in above-mentioned formula, mixing remove impurity, dry at cleaning is placed on 60 DEG C, after co-grinding, 100 orders sieve and obtain raw material mixing fine powders.
Step 2: heat 35min at fresh honey is placed in 40 DEG C, 60 mesh filter screen coarse filtration, 100 mesh filter screen fine filterings obtain refined honey.
Step 3: above-mentioned raw materials mixing fine powders and refined honey are mixed with 1:2 weight, be incubated 40min at 40 DEG C, after naturally cooling to room temperature, water-honeyed pill is processed in kneading, every ball 10g.
Patient 100 example that the present embodiment also selects the medical history state of an illness, age and sex suitable with embodiment 1, detection method is with embodiment 1, and its experimental result is as shown in table 1.
Embodiment 5
Present embodiments provide a kind of dietetic therapy anticancer preparation to make active ingredient raw material and be made up of following parts by weight:
Ganoderma 6 parts, 6 parts, Lentinus Edodes, Herba Taraxaci 7 parts, Germinatus Phragmitis 5 parts, Semen sojae atricolor 7 parts, Fructus Hippophae 5 parts, Fructus Lycopersici esculenti 4 parts, 5 parts, Radix Dauci Sativae, Semen Coicis 7 parts, 6 parts, Fructus Jujubae.
The present embodiment additionally provides the preparation method of dietetic therapy anticancer preparation (water-honeyed pill), and step is as follows:
Step one: take Ganoderma, Lentinus Edodes, Herba Taraxaci, Germinatus Phragmitis, Semen sojae atricolor, Fructus Hippophae, Fructus Lycopersici esculenti, Radix Dauci Sativae, Semen Coicis and Fructus Jujubae by weight portion in above-mentioned formula, dry at mixing remove impurity cleaning is placed on 60 DEG C, after co-grinding, 100 orders sieve and obtain raw material mixing fine powders.
Step 2: heat 30min at fresh honey is placed in 42 DEG C, 60 mesh filter screen coarse filtration, 100 mesh filter screen fine filterings obtain refined honey.
Step 3: above-mentioned raw materials mixing fine powders and refined honey are mixed with 1:1.5 weight, be incubated 40min at 30 DEG C, after naturally cooling to room temperature, water-honeyed pill is processed in kneading, every ball 10g.
Patient 100 example that the present embodiment also selects the medical history state of an illness, age and sex suitable with embodiment 1, detection method is with embodiment 1, and its experimental result is as shown in table 1.
Comparative example 1
The patient 100 selecting medical history, the state of an illness, age suitable with embodiment 1 with sex is routine, the raw material of active ingredient is made up of following parts by weight: Herba Taraxaci 0.5 part, Ganoderma 0.5 part, 1 part, Lentinus Edodes, Germinatus Phragmitis 5 parts, Semen sojae atricolor 9 parts, Fructus Hippophae 4 parts, Fructus Lycopersici esculenti 4 parts, 8 parts, Radix Dauci Sativae, Semen Coicis 6 parts, 8 parts, Fructus Jujubae, wherein the use amount of monarch drug Germinatus Phragmitis, Ganoderma, Lentinus Edodes reduces all in a large number.
Comparative example 2
The patient 100 selecting medical history, the state of an illness, age suitable with embodiment 1 with sex is routine, the raw material of active ingredient is made up of following parts by weight: 4 parts, Lentinus Edodes, Herba Taraxaci 5 parts, Germinatus Phragmitis 3 parts, Semen sojae atricolor 5 parts, Fructus Hippophae 4 parts, Fructus Lycopersici esculenti 3 parts, 4 parts, Radix Dauci Sativae, Semen Coicis 5 parts, 4 parts, Fructus Jujubae, reduces the Ganoderma of monarch drug simply in prescription.
Comparative example 3
The patient 100 selecting medical history, the state of an illness, age suitable with embodiment 1 with sex is routine, the raw material of active ingredient is made up of following parts by weight: Ganoderma 4 parts, Herba Taraxaci 5 parts, Germinatus Phragmitis 3 parts, Semen sojae atricolor 5 parts, Fructus Hippophae 4 parts, Fructus Lycopersici esculenti 3 parts, 4 parts, Radix Dauci Sativae, Semen Coicis 5 parts, 4 parts, Fructus Jujubae, reduces the Lentinus Edodes of monarch drug simply in prescription.
Comparative example 4
The patient 100 selecting medical history, the state of an illness, age suitable with embodiment 1 with sex is routine, the raw material of active ingredient is made up of following parts by weight: Ganoderma 4 parts, 4 parts, Lentinus Edodes, Germinatus Phragmitis 3 parts, Semen sojae atricolor 5 parts, Fructus Hippophae 4 parts, Fructus Lycopersici esculenti 3 parts, 4 parts, Radix Dauci Sativae, Semen Coicis 5 parts, 4 parts, Fructus Jujubae, reduces the Herba Taraxaci of monarch drug simply in prescription.
The raw material of the above comparative example makes water-honeyed pill by the following method, and step is as follows:
Step one: take Ganoderma, Lentinus Edodes, Herba Taraxaci, Germinatus Phragmitis, Semen sojae atricolor, Fructus Hippophae, Fructus Lycopersici esculenti, Radix Dauci Sativae, Semen Coicis and Fructus Jujubae by weight portion in above-mentioned formula, mixing remove impurity, dry at cleaning is placed on 60 DEG C, after co-grinding, 100 orders sieve and obtain raw material mixing fine powders.
Step 2: heat 30min at fresh honey is placed in 40 DEG C, 60 mesh filter screen coarse filtration, 100 mesh filter screen fine filterings obtain refined honey.
Step 3: above-mentioned raw materials mixing fine powders and refined honey are mixed with 1:2 weight, be incubated 40min at 30 DEG C, after naturally cooling to room temperature, water-honeyed pill is processed in kneading, every ball 10g.
Patient 100 example that comparative example 1,2,3,4 all selects medical history, the state of an illness, age and sex suitable with embodiment 1, detection method is with embodiment 1, and its treatment testing result is as shown in table 1.
Table 1
Can as apparent from table 1, the water-honeyed pill taking embodiment of the present invention 1-5 is all significantly better than the water-honeyed pill of comparative example 1-4 to the effect of various cancer, can find out from comparative example 1, the usage ratio of three taste monarchs drug reduces and can produce significant impact to the effect of this dietetic therapy anticancer preparation; Comparative example 2 lacks monarch drug Ganoderma, while causing most for the treatment of of cancer total effective rate to reduce, has a strong impact on the total effective rate to hepatocarcinoma, pulmonary carcinoma, esophageal carcinoma, curing gastric cancer; Comparative example 3 lacks monarch drug Lentinus Edodes, while causing most for the treatment of of cancer total effective rate to reduce, can cause further and obviously decline to the total effective rate of esophageal carcinoma, gastric cancer, pulmonary carcinoma; Comparative example 4 lacks monarch drug Herba Taraxaci, can cause the obvious decline to all cancer total effective rates.The water-honeyed pill of embodiment 1-5 feeds back after taking, and has the pain alleviating cancer friend, improves immunity of organisms, improves blood circulation and respiratory function, enhance appetite, improves sleep quality and the benefit of quality of life.As can be seen here, according to Chinese medicine " monarch " or the principles of formulating prescriptions huge meaning in the present invention claiming " major-minor assistant makes ", only have through large quantifier elimination dialectical, the extensive effectiveness of this dietetic therapy anticancer preparation of guarantee, if simply pile up together by mixed for various effective ingredient, the effect that good dietetic therapy is anticancer can not be played.Nature have the food of anti-cancer effect more than above these, applicant also once used other raw material by the principle prescription of " monarch ", and effect is all nothing like the present invention, therefore does not adopt.
Formula of the present invention can make the various peroral dosage forms on pharmaceutics, such as oral liquid, water-honeyed pill, tablet or capsule etc.
Claims (6)
1. a dietetic therapy anticancer preparation, is characterized in that: the crude drug making effective ingredient is made up of following parts by weight:
Ganoderma 2 ~ 6 parts, 2 ~ 6 parts, Lentinus Edodes, Herba Taraxaci 3 ~ 7 parts, Germinatus Phragmitis 1 ~ 5 part, Semen sojae atricolor 2 ~ 7 parts, Fructus Hippophae 1 ~ 5 part, Fructus Lycopersici esculenti 2 ~ 4 parts, 2 ~ 5 parts, Radix Dauci Sativae, Semen Coicis 3 ~ 7 parts, 2 ~ 6 parts, Fructus Jujubae.
2. dietetic therapy anticancer preparation as claimed in claim 1, is characterized in that: the crude drug making effective ingredient is made up of following parts by weight:
Ganoderma 4 parts, 4 parts, Lentinus Edodes, Herba Taraxaci 5 parts, Germinatus Phragmitis 3 parts, Semen sojae atricolor 5 parts, Fructus Hippophae 4 parts, Fructus Lycopersici esculenti 3 parts, 4 parts, Radix Dauci Sativae, Semen Coicis 5 parts, 4 parts, Fructus Jujubae.
3. dietetic therapy anticancer preparation according to claim 1 and 2, is characterized in that: described dietetic therapy anticancer preparation is the peroral dosage form on pharmaceutics.
4. dietetic therapy anticancer preparation according to claim 3, is characterized in that: described dietetic therapy anticancer preparation is oral liquid or water-honeyed pill or tablet or capsule.
5. the preparation method of dietetic therapy anticancer preparation according to claims 1 to 3, is characterized in that: comprise the following steps:
Described Ganoderma, Lentinus Edodes, Herba Taraxaci, Germinatus Phragmitis, Semen sojae atricolor, Fructus Hippophae, Fructus Lycopersici esculenti, Radix Dauci Sativae, Semen Coicis and Fructus Jujubae take by weight, mixing remove impurity, and dry at cleaning is placed on 50 ~ 60 DEG C, after co-grinding, 100 orders sieve and obtain raw material mixing fine powders;
Heat 30 ~ 40min at Mel being placed in 40 ~ 45 DEG C, 60 mesh filter screen coarse filtration, 100 mesh filter screen fine filterings, obtain refined honey;
Mixed homogeneously with weight ratio 1:0.4 ~ 4 with gained refined honey by the raw material mixing fine powders of gained, be incubated 30 ~ 40min at 30 ~ 40 DEG C, after naturally cooling to room temperature, kneading is processed and is obtained water-honeyed pill.
6. the preparation method of dietetic therapy anticancer preparation according to claim 5, is characterized in that: the weight ratio of described raw material mixing fine powders and refined honey is 1:1 ~ 1.5.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214996A (en) * | 2016-07-29 | 2016-12-14 | 于文洋 | A kind of Chinese herbal and crude drugs preparations to assisting treatment after cancer of late stage and postoperative and chemotherapy |
| CN108066743A (en) * | 2018-01-26 | 2018-05-25 | 陈保国 | A kind of Chinese medicine for the treatment of cancer and preparation method thereof |
| CN109481589A (en) * | 2018-11-02 | 2019-03-19 | 吴保喜 | A kind of preparation method of the toxin expelling anti-cancer capsule for treating lung cancer and dietotherapy anticancer |
| CN109549187A (en) * | 2018-11-14 | 2019-04-02 | 谢兆琪 | With the effective bacterium king's snail delicacy food dietotherapy spy's meals and preparation method thereof of anticancer |
| CN110537684A (en) * | 2019-04-23 | 2019-12-06 | 辽宁抗风竤生物医药科技有限责任公司 | Dietary therapy composition for treating lung cancer and preparation method thereof |
| CN111357994A (en) * | 2020-05-06 | 2020-07-03 | 曦晟源科贸有限公司 | Sea-buckthorn fruit and vegetable composite auxiliary preparation |
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Effective date of registration: 20160406 Address after: Longgang District of Shenzhen City, Guangdong province 518172 Dragon Street lime Wai Road No. 12 Applicant after: Shenzhen million Wanglong Biotechnology Co. Ltd. Address before: 2 2 unit 14D, sunshine rose garden, former route, Nanshan District, Guangdong, Shenzhen 518000, China Applicant before: Zhuang Shufan Applicant before: Wei Maoxiang Applicant before: Wu Kaijun Applicant before: Jin Chenglie Applicant before: Zhuang Lingling Applicant before: Bi Changhong |
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