CN104027412B - Disappear fast capsule and its preparation method and application yearningly - Google Patents
Disappear fast capsule and its preparation method and application yearningly Download PDFInfo
- Publication number
- CN104027412B CN104027412B CN201410248098.2A CN201410248098A CN104027412B CN 104027412 B CN104027412 B CN 104027412B CN 201410248098 A CN201410248098 A CN 201410248098A CN 104027412 B CN104027412 B CN 104027412B
- Authority
- CN
- China
- Prior art keywords
- parts
- weight portion
- capsule
- rhizoma
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title abstract description 6
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 15
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 15
- 241000255791 Bombyx Species 0.000 claims abstract description 9
- 241000237903 Hirudo Species 0.000 claims abstract 2
- 238000010791 quenching Methods 0.000 claims description 23
- 241000545744 Hirudinea Species 0.000 claims description 21
- 239000003814 drug Substances 0.000 claims description 20
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 15
- 241000255789 Bombyx mori Species 0.000 claims description 14
- 240000005373 Panax quinquefolius Species 0.000 claims description 14
- 230000000171 quenching effect Effects 0.000 claims description 12
- 230000035922 thirst Effects 0.000 claims description 12
- 241000132012 Atractylodes Species 0.000 claims description 11
- 244000131316 Panax pseudoginseng Species 0.000 claims description 11
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims description 11
- 241001522129 Pinellia Species 0.000 claims description 11
- 241000037740 Coptis chinensis Species 0.000 claims description 9
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 8
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 8
- 235000008326 Trichosanthes anguina Nutrition 0.000 claims description 8
- 244000078912 Trichosanthes cucumerina Species 0.000 claims description 8
- 235000013399 edible fruits Nutrition 0.000 claims description 8
- 244000273928 Zingiber officinale Species 0.000 claims description 7
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 7
- 235000008397 ginger Nutrition 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 6
- 235000011477 liquorice Nutrition 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 5
- 241000173529 Aconitum napellus Species 0.000 claims description 4
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 22
- 210000004369 blood Anatomy 0.000 abstract description 20
- 239000008280 blood Substances 0.000 abstract description 20
- 230000000694 effects Effects 0.000 abstract description 13
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract description 10
- 206010020772 Hypertension Diseases 0.000 abstract description 9
- 208000004930 Fatty Liver Diseases 0.000 abstract description 8
- 206010019708 Hepatic steatosis Diseases 0.000 abstract description 8
- 208000010706 fatty liver disease Diseases 0.000 abstract description 8
- 231100000240 steatosis hepatitis Toxicity 0.000 abstract description 8
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract description 3
- 210000000952 spleen Anatomy 0.000 description 13
- 206010062717 Increased upper airway secretion Diseases 0.000 description 11
- 208000026435 phlegm Diseases 0.000 description 11
- 210000002784 stomach Anatomy 0.000 description 11
- 230000007812 deficiency Effects 0.000 description 10
- 210000004072 lung Anatomy 0.000 description 9
- 235000009508 confectionery Nutrition 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 8
- 235000019634 flavors Nutrition 0.000 description 8
- 210000000038 chest Anatomy 0.000 description 6
- 241000227129 Aconitum Species 0.000 description 5
- 241000218202 Coptis Species 0.000 description 5
- 235000002991 Coptis groenlandica Nutrition 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 210000002216 heart Anatomy 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 206010011224 Cough Diseases 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 239000002398 materia medica Substances 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000010792 warming Methods 0.000 description 4
- 208000001380 Diabetic Ketoacidosis Diseases 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 3
- 208000031971 Yin Deficiency Diseases 0.000 description 3
- 229940023019 aconite Drugs 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 201000005577 familial hyperlipidemia Diseases 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 235000017443 Hedysarum boreale Nutrition 0.000 description 2
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 2
- 208000007976 Ketosis Diseases 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 240000004371 Panax ginseng Species 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 240000006023 Trichosanthes kirilowii Species 0.000 description 2
- 235000009818 Trichosanthes kirilowii Nutrition 0.000 description 2
- 206010045254 Type II hyperlipidaemia Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000004140 ketosis Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 2
- 229960003105 metformin Drugs 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 230000024121 nodulation Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 239000007939 sustained release tablet Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 240000008025 Alternanthera ficoidea Species 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 241000208173 Apiaceae Species 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 241000751139 Beauveria bassiana Species 0.000 description 1
- 241000255783 Bombycidae Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 208000031288 Combined hyperlipidaemia Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 206010061876 Obstruction Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 241000756042 Polygonatum Species 0.000 description 1
- 235000008737 Polygonatum biflorum Nutrition 0.000 description 1
- 244000046146 Pueraria lobata Species 0.000 description 1
- 235000010575 Pueraria lobata Nutrition 0.000 description 1
- 244000184734 Pyrus japonica Species 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 240000001341 Reynoutria japonica Species 0.000 description 1
- 235000018167 Reynoutria japonica Nutrition 0.000 description 1
- 239000009759 San-Chi Substances 0.000 description 1
- 241000522620 Scorpio Species 0.000 description 1
- 244000291333 Serissa japonica Species 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 241000218989 Trichosanthes Species 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 208000031975 Yang Deficiency Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 229940107666 astragalus root Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000002920 convulsive effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 235000018927 edible plant Nutrition 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000031877 prophase Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000012420 sanguinaria Nutrition 0.000 description 1
- 239000009490 scorpio Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The open one of the present invention disappears fast capsule and its preparation method and application yearningly, it comprises the Chinese medicinal components of following weight portion: Rhizoma Coptidis 20-40 weight portion, Rhizoma Pinelliae 10-25 weight portion, Fructus Trichosanthis 10-30 weight portion, Radix Panacis Quinquefolii 10-30 weight portion, Bombyx Batryticatus 10-25 weight portion, Radix Notoginseng 10-20 weight portion, Hirudo 10-25 weight portion, Radix Aconiti Lateralis Preparata 10-30 weight portion, Rhizoma Atractylodis Macrocephalae 10-20 weight portion, Rhizoma Zingiberis 10-20 weight portion, Radix Glycyrrhizae 5-10 weight portion; Can be applicable to the clinical hyperlipidemia, fatty liver, hypertension, the high blood viscosity that cure mainly type-II diabetes and diabetes merging, have received good curative effect.
Description
Technical Field
The invention relates to the technical field of thirsty-eliminating capsules, and particularly discloses a thirsty-eliminating capsule as well as a preparation method and application thereof.
Background
Diabetic ketosis is one of the most common complications of diabetes, and if the diabetic ketosis cannot be treated in time, diabetic ketoacidosis is easily complicated, so that the life is threatened. According to the theory of 'tonifying qi and warming yang' of the traditional Chinese medicine, the theory is that: qi deficiency is a prophase symptom, yang deficiency is a complication stage, and the complication almost relates to each organ of a human body and is a source of 'a plurality of diseases'. Diabetes is divided into seven types based on this theory: (1) common diabetes (qi deficiency and spleen weakness); (2) diabetes complicated with anemia (deficiency of both qi and yin); (3) diabetes mellitus with high blood uric acid (qi deficiency with heat); (4) diabetes complicated with hyperlipidemia, fatty liver (phlegm due to qi deficiency); (5) diabetes complicated with heart disease (qi deficiency with blood stasis); (6) diabetes complicated with nephropathy, impotence (insufficiency of yang-qi); (7) diabetes mellitus complicated with hypertension (qi deficiency with stagnation).
Liangxiaoling (Liangxiaoling) is disclosed in Liangxiaoling (Liangxiaoling, Liangxiaoling oral liquid quality standard research, Chinese medicine 2008(17):15-16) as an oral liquid for treating diabetes, deficiency of both qi and yin and blood stasis, which is prepared from 8 Chinese medicinal materials including kudzu vine root, astragalus root, Siberian solomonseal rhizome, fleece-flower root, root of Chinese trichosannthes, and has the functions of supplementing qi, nourishing yin, promoting blood circulation and promoting blood circulation. The application of the thirst-eliminating capsule to the treatment of type II diabetes by Zhangxiao has been primarily tried, and a thirst-eliminating capsule is disclosed in 56 cases of curative effect observation of the thirst-eliminating capsule to the treatment of yin deficiency and dryness heat type 2 diabetes ketosis (56 cases of curative effect observation of the thirst-eliminating capsule to the treatment of yin deficiency and dryness heat type 2 diabetes ketosis, and guang Ming TCM 2011(5): 971-. According to the needs of patients, 56 cases of diabetes mellitus with yin deficiency and dryness-heat are treated by adopting the traditional Chinese medicine syndrome differentiation and western medicine for reducing blood sugar without injecting insulin, and a good curative effect is achieved.
Disclosure of Invention
The invention aims to provide a capsule for quenching thirst and eliminating indigestion, which comprises Chinese medicinal components such as coptis chinensis, American ginseng, stiff silkworm, panax notoginseng and leech, and is mainly used for clinically treating type II diabetes and hyperlipidemia, fatty liver, hypertension and high blood viscosity which are caused by diabetes.
The invention also aims to provide a method for preparing the thirsty-vanishing fast capsule, which is characterized in that the traditional Chinese medicine components are ground into powder and then filled into a hollow capsule to prepare the thirsty-vanishing fast capsule, and the preparation method is simple, has low cost and can be industrially produced.
The invention also aims to provide an application of the thirsty-vanishing capsule in treating type II diabetes and diabetes-combined hyperlipidemia, fatty liver, hypertension and high blood viscosity.
The invention provides a thirsty-quenching capsule, which comprises the following traditional Chinese medicine components: coptis root, American ginseng, stiff silkworm, panax notoginseng and leech.
Preferably, the thirsty-quenching capsule comprises the following traditional Chinese medicine components in parts by weight: 20-40 parts of coptis chinensis, 10-30 parts of American ginseng, 10-25 parts of stiff silkworm, 10-20 parts of pseudo-ginseng and 10-25 parts of leech.
Coptis root, rhizoma Coptidis, being bitter and cold, enters heart, spleen, stomach and gallbladder meridians, is good at clearing heat and drying dampness, purging fire and removing toxicity, and clearing stomach fire, and can be used for treating diabetes due to excessive stomach fire, hyperphagia and hunger. American ginseng is sweet in taste and slightly bitter in flavor, and cold in nature enters lung, stomach, heart and kidney meridians. Tonify qi, nourish yin, clear fire and promote the production of body fluid. It can be used for treating deficiency of both qi and yin, cough, asthenia heat, vexation, fatigue, internal heat, diabetes, xerostomia, and dry tobacco. Bombyx Batryticatus is pungent, salty and neutral in flavor, and enters liver, lung and stomach meridians. Dispel wind and stop spasm, resolve phlegm and dissipate nodulation, remove toxicity and relieve sore throat. It can be used for treating convulsive epilepsy, convulsion, apoplexy, facial distortion, migraine, headache, sore throat, and lymphoid tuberculosis. The bibliography: although pungent and mild in flavor and not toxic, its specific application is pungent and salty but inferior in flavor and slightly warm in qi. Thin smell, floating and ascending, yang entering foot jueyin, hand taiyin and shaoyang meridians. Notoginseng, sweet, slightly bitter and warm. It enters liver and stomach meridians. Remove blood stasis, stop bleeding, activate blood, relieve pain, tonify deficiency and strengthen body. Modern pharmacological research proves that the pseudo-ginseng reduces blood pressure, slows down heart rate, reduces myocardial oxygen consumption, dilates cerebral vessels, enhances cerebral vessel blood flow, improves organism immunity, and has the functions of analgesia, anti-inflammation and anti-aging. Leech, salty and bitter in taste, neutral in nature. It enters liver meridian. Break blood and dispel stasis, dredge meridians and eliminate mass. It can be used for treating amenorrhea due to blood stasis, and abdominal mass. Modern pharmacological research shows that leeches have the effects of resisting blood coagulation and thrombus, obviously inhibiting platelet aggregation and reducing triglyceride and cholesterol in serum. The compatibility of pseudo-ginseng, leech and stiff silkworm is adopted, the blood viscosity can be reduced, the blood circulation is promoted, the blood stasis is removed, and the clinical treatment of the hyperlipemia, the fatty liver, the hypertension and the high blood viscosity which are combined in the type II diabetes and the diabetes have good effects.
Preferably, the thirsty-quenching capsule comprises the following traditional Chinese medicine components: coptis root, pinellia tuber, snakegourd fruit, American ginseng, stiff silkworm, pseudo-ginseng and leech.
Preferably, the thirsty-quenching capsule comprises the following traditional Chinese medicine components in parts by weight: 20-40 parts of coptis chinensis, 10-25 parts of pinellia ternate, 10-30 parts of snakegourd fruit, 10-30 parts of American ginseng, 10-25 parts of stiff silkworm, 10-20 parts of pseudo-ginseng and 10-25 parts of leech.
Pinellia tuber, rhizoma Pinelliae is pungent in flavor and warm in nature, enters spleen, stomach and lung channels, eliminates dampness and phlegm, lowers adverse qi to arrest vomiting, relieves distension and fullness and dissipates stasis, and is mainly used for treating cough, asthma, excessive phlegm, vomiting, regurgitation, fullness in chest and stomach, headache, vertigo and other symptoms. The book of materia Medica Yan: ban Xia can clear phlegm and tonify spleen, so it can divide water. Spleen is aversion to dampness, dampness is soft and stranded, and water cannot be produced. "treatise on drug Property: pinellia ternate has the effects of eliminating phlegm and saliva, stimulating appetite, tonifying spleen, stopping vomiting, removing phlegm fullness in chest and descending lung qi. Gua Lou is sweet in taste, slightly bitter and cold in nature, and enters lung, stomach and large intestine meridians. Clear heat and resolve phlegm, relieve chest stuffiness and dissipate nodulation, moisten dryness and smooth intestines. It can be used for treating cough due to lung heat, thoracic obstruction, diabetes, and constipation. Supplement to the Yanyi of Ben Cao (supplement to the Yan Yi of materia Medica): gua Lou Shi, in the book Ben Cao, is indicated for chest impediment by sweet flavor with moistening property, sweet flavor can tonify lung, moisten and descend qi. For phlegm in the chest, it is also the essential herb for treating cough because it is sweet and mild in action of descending and descending due to lung fire. Also, it is indicated for diabetes because it washes greasy dirt in chest and diaphragm. Modern pharmacological research shows that trichosanthes expands coronary artery, has obvious protection effect on acute myocardial ischemia and has the function of reducing blood fat. The combination of Huang Lian, ban Xia and Gua Lou can clear heat, resolve masses and remove phlegm, and treat hypertension, hyperlipemia and hyperglycemia with phlegm, stasis and heat.
Preferably, the thirsty-quenching capsule comprises the following traditional Chinese medicine components: coptis root, American ginseng, white muscardine silkworm, pseudo-ginseng, leech, monkshood, bighead atractylodes rhizome, dried ginger and liquorice.
Preferably, the thirsty-quenching capsule comprises the following traditional Chinese medicine components in parts by weight: 20-40 parts of coptis chinensis, 10-30 parts of American ginseng, 10-25 parts of stiff silkworm, 10-20 parts of pseudo-ginseng, 10-25 parts of leech, 10-30 parts of monkshood, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of dried ginger and 5-10 parts of liquorice.
Gan Jiang is pungent in flavor and hot in nature. It enters spleen, stomach, heart and lung meridians. Warming the middle energizer to dispel cold, restoring yang and activating collaterals. It is indicated for cholera, abdominal pain and blood block with the main action of warming middle energizer. Tang Ben Cao (materia Medica of Tang Dynasty): for wind-cold, descending qi, stopping bleeding, dispersing all collaterals and slight sweating. In Yun Qi of the main treatment Mi Yao (secret essences), it can activate heart-qi, strengthen yang, remove deep-cold from viscera, and induce cold-qi of all meridians, so it is indicated for cold-type abdominal pain. Fu Zi is pungent, sweet and hot, and enters heart, spleen meridian. Revive yang and rescue collapse, tonify fire and strengthen yang. The book of materia Medica: the ingredient Fu Zi is the key herb … … for dredging twelve meridians and pure yang because it is pungent, warm and hot with good property. Bai Zhu is sweet, bitter and warm. It enters spleen and stomach meridians. To replenish qi and invigorate the spleen. The herbal medicine Tongxian: "clear qi rises well when the soil is strong, fine qi rises, foul qi is removed well, and dregs are transported downwards". Modern pharmacological research shows that the bighead atractylodes rhizome can protect the liver, promote the function of gallbladder, promote urination and reduce blood sugar. Licorice root, radix Glycyrrhizae strengthens the spleen and harmonizes the effects of the other drugs in the recipe. The combination of Fu Zi, Bai Zhu, gan Jiang and gan Cao can strengthen the spleen and warm the kidney, promote the transportation and transformation of the spleen and the warming of the kidney, and restrict the bitter and cold property of Huang Lian.
Preferably, the thirsty-quenching capsule comprises the following traditional Chinese medicine components: coptis chinensis, pinellia ternate, trichosanthes kirilowii maxim, American ginseng, stiff silkworm, pseudo-ginseng, leech, monkshood, bighead atractylodes rhizome, dried ginger and liquorice.
Preferably, the thirsty-quenching capsule comprises the following traditional Chinese medicine components in parts by weight: 20-40 parts of coptis chinensis, 10-25 parts of pinellia ternate, 10-30 parts of snakegourd fruit, 10-30 parts of American ginseng, 10-25 parts of stiff silkworm, 10-20 parts of pseudo-ginseng, 10-25 parts of leech, 10-30 parts of monkshood, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of dried ginger and 5-10 parts of liquorice.
The invention also provides a method for preparing the thirsty-vanishing fast capsule, which comprises the steps of proportioning the traditional Chinese medicine components in parts by weight, grinding the traditional Chinese medicine components into powder, and filling the powder into a hollow capsule to prepare the thirsty-vanishing fast capsule.
The invention provides application of the thirsty-removing capsule in treating type II diabetes and diabetes-complicated hyperlipidemia, fatty liver, hypertension and high blood viscosity.
The invention has the following beneficial effects:
1. the capsule for quenching thirst and eliminating indigestion comprises Chinese medicinal components such as coptis chinensis, American ginseng, stiff silkworm, panax notoginseng and leech, and is mainly used for clinically treating type II diabetes and hyperlipidemia, fatty liver, hypertension and high blood viscosity which are caused by diabetes.
2. The preparation method of the thirsty-removing capsule is simple, has low cost and can be industrially produced.
Detailed Description
The present invention will be further clearly understood from the specific examples and comparative examples of the present invention given below, which are not intended to limit the present invention. The parts of the specific examples and comparative examples which are not described in detail are obtained by means of the prior art, the known technical means and the industry standard.
All percentages used in the present invention are by weight unless otherwise indicated.
Example 1
According to the formula proportion of table 1, the Chinese medicinal components: 40g of coptis chinensis, 25g of processed pinellia ternate, 30g of dried snakegourd fruit, 30g of American ginseng, 10g of stiff silkworm, 10g of panax notoginseng, 10g of leech in clear water, 10g of cooked monkshood, 10g of fried bighead atractylodes rhizome, 10g of dried ginger and 5g of liquorice are crushed, sieved by a 300-mesh sieve and filled into a No. 0 capsule, namely a machine-made thirst quenching capsule. Wherein,
bombyx Batryticatus, alternative name: bombyx Batryticatus and Bombyx Batryticatus are dry whole silkworm obtained by infecting larva of Bombycis Mori of Bombycidae with Beauveria bassiana. Cylindrical, and is bent and shrunk. The length is about 2-5 cm and the diameter is 4-7 mm. The surface is grayish white or light brown, and is mostly frosted with white powder.
The processed pinellia tuber is the processed product of pinellia tuber.
Fructus Trichosanthis is fructus Trichosanthis, and is also named as fructus Momordicae Charantiae, fructus Trichosanthis, and fructus Callicarpae Longipedunculatae; the dried snakegourd fruit is dried snakegourd fruit after being dried and dried in the sun.
Pseudo-ginseng, also known as panax notoginseng, sanguinaria japonica, serissa serissoides, scorpio grass, also known as showa, sang ginseng, panax notoginseng, sanchi, panax notoginseng, and the like in ancient times, belongs to perennial herb of panax ginseng belonging to the family araliaceae, belongs to the family umbelliferae, is a unique rare Chinese medicinal material, and is also one of the earliest medicinal and edible plants in China; the big radix Notoginseng is the first-class radix Notoginseng.
The fresh leech is the leech without salt, and is the genuine leech.
The prepared aconite is the processed Chinese medicine aconite.
The actions of Bai Zhu are slightly different due to different processing. The common clinical processing method of the largehead atractylodes rhizome comprises the following steps: raw white atractylodes rhizome, stir-baked white atractylodes rhizome, parched white atractylodes rhizome and the like. Parching Atractylodis rhizoma, also called preparata Atractylodis rhizoma, spreading a part of testa Tritici in a hot pan, adding ten parts of Atractylodis rhizoma slices, parching to light yellow, taking out, sieving to remove testa, and cooling. Stir-baked Bai Zhu is good at drying dampness.
Example 2
The process of this example was substantially the same as example 1, and the formulation ratio was adjusted as detailed in Table 1.
Example 3
The process of this example was substantially the same as example 1, and the formulation ratio was adjusted as detailed in Table 1.
Example 4
The process of this example was substantially the same as example 1, and the formulation ratio was adjusted as detailed in Table 1.
Example 5
The process of this example was substantially the same as example 1, and the formulation ratio was adjusted as detailed in Table 1.
TABLE 1 formulation
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | |
| Coptis root/g | 40 | 20 | 30 | 35 | 25 |
| Processed pinellia tuber/g | 25 | 10 | 20 | 15 | — |
| Dried snakegourd fruit/g | 30 | 10 | 20 | 25 | — |
| American ginseng/g | 30 | 10 | 20 | 25 | 15 |
| Bombyx Batryticatus/g | 10 | 25 | 15 | 20 | 18 |
| Notoginseng radix/g | 10 | 20 | 15 | 12 | 18 |
| Leech cleaning per gram | 10 | 25 | 20 | 15 | 18 |
| Prepared aconite/g | 10 | 30 | 20 | — | 15 |
| Parched Atractylodis rhizoma/g | 10 | 20 | 15 | — | 18 |
| Dried ginger/g | 10 | 20 | 15 | — | 12 |
| Licorice root/g | 5 | 10 | 8 | — | 6 |
Application examples
The thirsty-eliminating capsule of the invention is used for clinically treating patients with type II diabetes and diabetes combined with hyperlipemia, fatty liver, hypertension and high blood viscosity. The thirsty-quenching capsule is taken by a treatment group 3 times a day, 5 capsules each time. The control group was treated with metformin sustained release tablets.
The treatment results are as follows: of the 169 patients in the treatment group, 35 patients were cured, accounting for 20.7%; 39 cases of remarkable effect account for 23 percent; the improvement of 59 cases accounts for 34.3 percent; 37 invalid cases account for 21.9%; the total effective rate of treatment is 78.1%. In 162 cases of the control group, 17 cases are cured, accounting for 10.5%; 26 cases of obvious effect account for 16 percent; 42 cases are advanced, accounting for 25.9 percent; 77 cases with no effect, accounting for 47%; the total effective rate of the treatment is 47.5%. The comparison of the total effective rate of the two groups of treatment is less than 0.01. Therefore, the curative effect of the thirsty-removing capsule group is obviously better than that of the metformin sustained-release tablet group (p is less than 0.01).
The above disclosure is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the scope of the present invention, therefore, the present invention is not limited by the appended claims.
Claims (9)
1. A thirsty-quenching capsule is characterized in that: is prepared from the following Chinese medicinal components: rhizoma Coptidis, rhizoma Pinelliae, fructus Trichosanthis, radix Panacis Quinquefolii, Bombyx Batryticatus, radix Notoginseng, Hirudo, radix Aconiti lateralis Preparata, rhizoma Atractylodis Macrocephalae, rhizoma Zingiberis, and radix Glycyrrhizae; wherein the weight ratio of the traditional Chinese medicine components is as follows: 20-40 parts of coptis chinensis, 10-25 parts of pinellia ternate, 10-30 parts of snakegourd fruit, 10-30 parts of American ginseng, 10-25 parts of stiff silkworm, 10-20 parts of pseudo-ginseng, 10-25 parts of leech, 10-30 parts of monkshood, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of dried ginger and 5-10 parts of liquorice.
2. The thirst quenching capsule according to claim 1, wherein: the rhizoma Pinelliae is processed rhizoma Pinelliae.
3. The thirst quenching capsule according to claim 1, wherein: the fructus trichosanthis is dry fructus trichosanthis.
4. The thirst quenching capsule according to claim 1, wherein: the Bombyx Batryticatus is Bombyx Batryticatus.
5. The thirst quenching capsule according to claim 1, wherein: the Notoginseng radix is radix Notoginseng.
6. The thirst quenching capsule according to claim 1, wherein: the leech is clear leech.
7. The thirst quenching capsule according to claim 1, wherein: the radix Aconiti lateralis is prepared from radix Aconiti lateralis Preparata.
8. The thirst quenching capsule according to claim 1, wherein: the Atractylodis rhizoma is parched Atractylodis rhizoma.
9. A method for preparing the thirst quenching capsule according to any one of claims 1 to 8, wherein: the traditional Chinese medicine components are mixed according to the weight part ratio, ground into powder and filled into a hollow capsule to prepare the thirsty-quenching capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410248098.2A CN104027412B (en) | 2014-06-06 | 2014-06-06 | Disappear fast capsule and its preparation method and application yearningly |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410248098.2A CN104027412B (en) | 2014-06-06 | 2014-06-06 | Disappear fast capsule and its preparation method and application yearningly |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104027412A CN104027412A (en) | 2014-09-10 |
| CN104027412B true CN104027412B (en) | 2016-04-20 |
Family
ID=51458557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410248098.2A Expired - Fee Related CN104027412B (en) | 2014-06-06 | 2014-06-06 | Disappear fast capsule and its preparation method and application yearningly |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104027412B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306656B (en) * | 2014-10-31 | 2017-06-06 | 福建中医药大学附属人民医院 | It is a kind of to eliminate hyperglycemia toxicity to protect the prescription and preparation method and purposes of blood vessel |
| CN105343828A (en) * | 2015-11-30 | 2016-02-24 | 姜辉阳 | Traditional Chinese medicine composition for treating diabetes |
| CN105726599A (en) * | 2016-03-17 | 2016-07-06 | 罗健 | Medicine for treating diabetes |
| CN108014186A (en) * | 2018-01-15 | 2018-05-11 | 马飞 | Treat Chinese medicine composition of diabetes and its preparation method and application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642529B (en) * | 2009-08-20 | 2011-06-08 | 余东山 | Preparation capable of treating diabetes |
-
2014
- 2014-06-06 CN CN201410248098.2A patent/CN104027412B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN104027412A (en) | 2014-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107029146B (en) | Traditional Chinese medicine composition for clearing lung, eliminating phlegm, tonifying qi, invigorating spleen and nourishing lung and preparation method thereof | |
| CN104873947A (en) | Medicinal composition for treating dog acute upper gastrointestinal hemorrhage and preparation method thereof | |
| CN103768523A (en) | Chinese herbal medicine compound preparation for treating malignant tumors and preparation method of compound preparation | |
| CN104027412B (en) | Disappear fast capsule and its preparation method and application yearningly | |
| CN104757669A (en) | Blood pressure and blood lipid lowering health drink and preparation method thereof | |
| CN104001045A (en) | Drug for treating dog pneumonia and preparation method thereof | |
| CN105326939A (en) | Traditional Chinese medicine for treating heart and cerebral vusculer diseases | |
| CN101313994A (en) | Traditional Chinese medicine capsule for treating auricular fibrillation | |
| CN102579799A (en) | Traditional Chinese medicine composition for treating postpartum fever with blood deficiency | |
| CN105796685A (en) | Method for preparing traditional Chinese medicine composition for treating myocardial infarction | |
| CN104800600A (en) | Medicine for treating hypertension | |
| CN102961461A (en) | Traditional Chinese medicine composition for treating viral myocarditis | |
| CN117180387B (en) | Composition for treating wind-phlegm obstruction type peripheral facial paralysis and preparation method thereof | |
| CN115006491B (en) | Traditional Chinese medicine composition for treating chronic atrophic gastritis and preparation method thereof | |
| CN108721540A (en) | Treat the Chinese medicine preparation of six kinds of situations of liver cancer | |
| CN106668349A (en) | Traditional Chinese medicine composition used after hemobilia operation and preparation method thereof | |
| CN108524651B (en) | Traditional Chinese medicine composition for treating tracheitis | |
| CN105853882A (en) | Medicine for treating stomach illness and preparation method | |
| CN106306205A (en) | Solid beverage with effects of relieving swelling and pain and making method thereof | |
| CN113827691A (en) | Composition for relieving sports fatigue and chronic fatigue syndrome and preparation method thereof | |
| CN105055978A (en) | Pharmaceutical composition for treating alcoholic distention | |
| CN105079318A (en) | Blood-activating pain-relieving preparation for treating prosopalgia and preparation method | |
| CN104984060A (en) | Traditional Chinese medicament for treating coronary heart disease | |
| CN104147386A (en) | Traditional Chinese medicinal preparation for treating migraine and preparation method thereof | |
| CN110946981A (en) | A Chinese medicinal composition for treating various diseases, and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160420 Termination date: 20180606 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |