CN105769608A - Sterilization and disinfection hand sanitizer and preparation method thereof - Google Patents
Sterilization and disinfection hand sanitizer and preparation method thereof Download PDFInfo
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- CN105769608A CN105769608A CN201610214332.9A CN201610214332A CN105769608A CN 105769608 A CN105769608 A CN 105769608A CN 201610214332 A CN201610214332 A CN 201610214332A CN 105769608 A CN105769608 A CN 105769608A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- Dermatology (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a sterilization and disinfection hand sanitizer and a preparation method thereof.The hand sanitizer mainly comprises sterilization components and purified water, and the sterilization components comprise hydroxypropyl methyl cellulose, cocamidopropyl betaine, cocamidopropyl dimethylamine oxide, alkyl glycoside, glycerin, polyhexamethylen guanidine hydrochloride, didecyl dimethyl ammonium bromide, sodium chloride and essence.The preparation method comprises the steps that alkaline surfactants are dissolved, the pH is adjusted to be weakly acidic, polyhexamethylene guanidine is added, mixing is conducted, and the sterilization and disinfection hand sanitizer is obtained.According to the sterilization and disinfection hand sanitizer and the preparation method thereof, sterilization capacities of all the raw materials are exerted most efficiently, chemical resistance is not caused, and the sterilization and bacteriostasis capacities are high; the hand sanitizer is small in dosage, low in cost and price, economical, practical, easy to rinse, high in dirt-removing capacity, good in sterilization effect and harmless to body health and can be widely applied to medical industry and daily life.
Description
Technical field
The present invention relates to Irrigation sterilization field, be specifically related to a kind of sterilizing handwashing liquid and preparation method thereof.
Background technology
In life and work, the both hands of people can contact with microorganism, the even article of pathogenic microorganism, so that both hands bacterial infection.Preventing the measure infected, form good Personal hygiene custom and accomplish that duty is washed one's hands, diligent sterilization, stopping to propagate because of hands contact is wherein one of measure.At present, handwashing liquid is accepted by increasing consumer as a kind of daily articles for washing, and has entered into huge numbers of families.And at present the kind of detergent is also multifarious, various be primary raw material with dodecyl alcohol sodium sulfate, ammonium alkyl sulfate, dodecyl polyoxyethylene sodium sulfate, sodium chloride, essence and pigment and water etc. the product of detergent class arise at the historic moment.In prior art, some handwashing liquid adopts the composite of cationic germicide and anion surfactant.Wherein polyhexamethylene guanidine is due to its efficient sterilizing, is used in a large number in current handwashing liquid.
The Chinese patent that publication number is CN101684435B discloses a kind of disinfection hand cleanser, the cationic germicide that this handwashing liquid passes through such as polyhexamethylene guanidine, thickening agent, amphoteric surfactant or nonionic or cationic surfactant and alcohols mixing gained, its preparation method is to be added together to purified water by all kinds of raw materials, and regulating pH is that 6-7 obtains.The Chinese patent of publication number CN102018634A discloses compound polyhexamethylene guanidine antibacterial hand sanitizer and preparation method thereof, wherein also include polyhexamethylene guanidine, amphoteric surfactant or nonionic or cationic surfactant and glycerol (alcohol) class, its preparation method is to be initially charged cellulose and surfactant, adjusts pH and obtain product after adding polyhexamethylene guanidine.Publication number CN104840378A discloses skin-protection type disinfection hand cleanser and preparation method thereof, and the main formula of this handwashing liquid is mainly polyhexamethylene guanidine, surfactant and alcohol oils, and its preparation method is to mix all raw materials and pH adjusting agent to obtain product.
In sum, being currently fed the handwashing liquid of polyhexamethylene guanidine, its preparation method is all be mixed together with other surfactants and pH value to add the bactericidal effect affecting polyhexamethylene guanidine.Polyhexamethylene guanidine is a kind of multipurpose high one's share of expenses for a joint undertaking polymer, but after mixing with surfactant, it is easy to cause the antagonism problem between each raw material, make polyhexamethylene guanidine lose bactericidal effect；And polyhexamethylene guanidine is acid, and bactericidal effect is best in acid condition, but the surfactant of current most of practicality is alkalescence, in process for preparation, it is easy to cause the problem that polyhexamethylene guanidine sterilization was lost efficacy.
Summary of the invention
In order to solve above-mentioned deficiency and defect, it is good that the present invention proposes a kind of bactericidal and bacteriostatic effect, and softness, conditioning and low-temperature stability easily rinse, soft skin, sterilizing handwashing liquid of moisturizing and preparation method thereof.
To achieve these goals, the present invention is achieved through the following technical solutions:
A kind of sterilizing handwashing liquid, it is characterised in that: mainly include following components, be by mass percentage:
Preferably, a kind of sterilizing handwashing liquid, mainly include following components, be by mass percentage:
A kind of preparation method of sterilizing handwashing liquid, comprise the following steps: weigh after hydroxypropyl methylcellulose dissolves in the purified water of 1/3, it is sequentially added into after cocamido propyl betaine, cocamidopropyl propyl amide amine oxide, alkyl polyglucoside and glycerol is sufficiently mixed, after regulating pH to 5.5-6.5 with acid-base modifier, after adding Polyhaxemethylenguanidine Hydrochloride and Deciquam mixing, add sodium chloride and regulate denseness, after adding essence, add remaining purified water to stir, obtain product.
Preferably, acid-base modifier described above is the sodium hydroxide solution of 1%.
In the present invention, the guanidine radicals in Polyhaxemethylenguanidine Hydrochloride possesses significantly high activity, polymer is made to become electropositive, it is easily absorbing each bacterioid, the virus that are negative in surface, antibacterial then can be surrounded parcel by the polymer of long-chain firmly, thus inhibiting breathing and the nutrition channel of bacterial virus, making bacterial virus lose fertility, polymer one's share of expenses for a joint undertaking blocks the nutrient substance exchange of pathogenic microorganism, and therefore the fungicidal effectiveness of Polyhaxemethylenguanidine Hydrochloride is much higher than other guanidine compound.Due to the long chain type layout of Polyhaxemethylenguanidine Hydrochloride, do not contain heterocyclic group, therefore its toxicity is extremely low.Some antibiotic can be developed immunity to drugs by antibacterial by changing a link of its DNA, but no matter how pathogen makes a variation, all must carry out nutrient substance exchange with the external world, thus, the specific physical effect sterilization mechanism of Polyhaxemethylenguanidine Hydrochloride, do not destroy DNA of bacteria, make all kinds of pathogen that it not developed immunity to drugs.
Cocamido propyl betaine in the present invention, it is a kind of zwitterionic surfactant, under acidity and alkali condition, is respectively provided with excellent stability, presents male and female respectively ionic, its compatibility is good, zest is little, soluble in water, to ph stability, foam is many, strong detergency, has excellent thickening property, flexibility, bactericidal properties, antistatic behaviour, hard water resistance property, can significantly improve the washing softness of series products, conditioning and low-temperature stability.
Cocamidopropyl propyl amide amine oxide in the present invention, and anions and canons, nonionic and other amphoteric surfactant compound compatibilities, form synergism, reach the purpose of compound synergic, improve the comprehensive scourability of product；Have and nurse one's health antistatic property preferably；Anion surfactant is had good thickening power；There is outstanding foaming and steady bubble ability.Skin is had good protective effect by the addition of glycerol, and gentleness does not hurt hands, and also can reduce the zest of other surfactant；
Sterilizing handwashing liquid of the present invention and preparation method thereof, compared with prior art, it has the beneficial effects that:
(1) adopting Polyhaxemethylenguanidine Hydrochloride is major antibacterial agent, and add both sexes table cocamido propyl betaine alive, cocamidopropyl propyl amide amine oxide and alkyl polyglucoside, ratio between Polyhaxemethylenguanidine Hydrochloride and surfactant is through the content proportioning of science, so as to the mutual opposing problem avoiding mixing and producing, Polyhaxemethylenguanidine Hydrochloride and amphoteric surfactant synergism, the each sterilizing ability making raw material obtains the performance of maximal efficiency, not producing drug resistance, sterilization and bacteriostasis are strong；And consumption is few, cost is low, and low price is economical and practical.
(2) in the preparation method of sterilizing handwashing liquid of the present invention, after first surfactant first being dissolved, adjust pH value after faintly acid, add Polyhaxemethylenguanidine Hydrochloride, owing to before adding Polyhaxemethylenguanidine Hydrochloride, solution just presents faintly acid, add as after acid polyhexamethylene guanidine, it is possible to make Polyhaxemethylenguanidine Hydrochloride be in the environment of acidity, strengthen its antibiotic property.
(3) raw bactericidal material used by the present invention is medical grade or cosmetics-stage, and skin is non-stimulated, adds glycerol, reducing the injury to skin, easily rinse, dirt-removing power is strong, bactericidal effect is good, does not produce harm to healthy, can be widely used for pharmaceuticals industry, daily life.
The property indices of sterilizing handwashing liquid of the present invention, as shown in table 1:
| Project | Performance and index |
| Outward appearance | Colourless, thickness |
| Abnormal smells from the patient | Faint fragranced |
| PH value | 5.5-7.5 |
| Microbiological indicator | Meet GB15979 regulation |
| Repeatedly intact skin irritant test | Non-stimulated |
Table 1
The antibacterial effect of sterilizing handwashing liquid of the present invention, as shown in table 2:
| Dilution ratio (medicine: water) | Effective object | Action time | Killing rate |
| 1:1 | Staphylococcus aureus | 2min | >=90% |
| 1:1 | Escherichia coli | 2min | >=90% |
| 1:1 | Candida albicans | 2min | >=90% |
Table 2
Detailed description of the invention
The present invention is further described below in conjunction with specific embodiment.
Embodiment 1
A kind of sterilizing handwashing liquid, mainly includes following components, is by mass percentage: hydroxypropyl methylcellulose 2%；Cocamido propyl betaine 0.7%；Cocamidopropyl propyl amide amine oxide 2.0%；Alkyl polyglucoside 2%；Glycerol 0.5%；Polyhaxemethylenguanidine Hydrochloride 1.0%；Deciquam 0.07%；Sodium chloride 0.1%；Essence 0.06%, all the other are purified water.
Preparation method step is: the purified water by 1/3 heats to 60 DEG C, add hydroxybenzyl cellulose dissolution, it is sequentially added into cocamido propyl betaine, cocamidopropyl propyl amide amine oxide, alkyl polyglucoside, glycerol, sodium hydroxide solution with 1% regulates pH to 5.5-6.5, add Polyhaxemethylenguanidine Hydrochloride and Deciquam, add sodium chloride and regulate denseness, add essence, add remaining purification, stir.
Embodiment 2
A kind of sterilizing handwashing liquid, mainly includes following components, is by mass percentage: hydroxypropyl methylcellulose 5%；Cocamido propyl betaine 1.4%；Cocamidopropyl propyl amide amine oxide 2.8%；Alkyl polyglucoside 1.5%；Glycerol 1.5%；Polyhaxemethylenguanidine Hydrochloride 1.6%；Deciquam 0.5%；Sodium chloride 0.05%；Essence 0.1%, all the other are purified water.
Preparation method step is: the purified water by 1/3 heats to 60 DEG C, add hydroxybenzyl cellulose dissolution, it is sequentially added into cocamido propyl betaine, cocamidopropyl propyl amide amine oxide, alkyl polyglucoside, glycerol, sodium hydroxide solution with 1% regulates pH to 5.5-6.5, add Polyhaxemethylenguanidine Hydrochloride and Deciquam, add sodium chloride and regulate denseness, add essence, add remaining purification, stir.
Embodiment 3
A kind of sterilizing handwashing liquid, mainly includes following components, is by mass percentage: hydroxypropyl methylcellulose 1%；Cocamido propyl betaine 2.5%；Cocamidopropyl propyl amide amine oxide 2.5%；Alkyl polyglucoside 2%；Glycerol 1.33%；Polyhaxemethylenguanidine Hydrochloride 0.5%；Deciquam 0.25%；Sodium chloride 0.03%；Essence 0.05%, all the other are purified water.
Preparation method step is: the purified water by 1/3 heats to 60 DEG C, add hydroxybenzyl cellulose dissolution, it is sequentially added into cocamido propyl betaine, cocamidopropyl propyl amide amine oxide, alkyl polyglucoside, glycerol, sodium hydroxide solution with 1% regulates pH to 5.5-6.5, add Polyhaxemethylenguanidine Hydrochloride and Deciquam, add sodium chloride and regulate denseness, add essence, add remaining purification, stir.
Embodiment 4
A kind of sterilizing handwashing liquid, mainly includes following components, is by mass percentage: hydroxypropyl methylcellulose 3%；Cocamido propyl betaine 1.0%；Cocamidopropyl propyl amide amine oxide 2.5%；Alkyl polyglucoside 3%；Glycerol 2%；Polyhaxemethylenguanidine Hydrochloride 0.2%；Deciquam 0.7%；Sodium chloride 0.01%；Essence 0.04%, all the other are purified water.
Preparation method step is: the purified water by 1/3 heats to 60 DEG C, add hydroxybenzyl cellulose dissolution, it is sequentially added into cocamido propyl betaine, cocamidopropyl propyl amide amine oxide, alkyl polyglucoside, glycerol, sodium hydroxide solution with 1% regulates pH to 5.5-6.5, add Polyhaxemethylenguanidine Hydrochloride and Deciquam, add sodium chloride and regulate denseness, add essence, add remaining purification, stir.
Embodiment 5
A kind of sterilizing handwashing liquid, mainly includes following components, is by mass percentage: hydroxypropyl methylcellulose 2%；Cocamido propyl betaine 2.6%；Cocamidopropyl propyl amide amine oxide 1.4%；Alkyl polyglucoside 1.5%；Glycerol 3%；Polyhaxemethylenguanidine Hydrochloride 0.6%；Deciquam 0.2%；Sodium chloride 0.03%；Essence 0.05%, all the other are purified water.
Preparation method step is: the purified water by 1/3 heats to 60 DEG C, add hydroxybenzyl cellulose dissolution, it is sequentially added into cocamido propyl betaine, cocamidopropyl propyl amide amine oxide, alkyl polyglucoside, glycerol, sodium hydroxide solution with 1% regulates pH to 5.5-6.5, add Polyhaxemethylenguanidine Hydrochloride and Deciquam, add sodium chloride and regulate denseness, add essence, add remaining purification, stir
The technical scheme above embodiment of the present invention provided is described in detail, principle and the embodiment of the embodiment of the present invention are set forth by specific case used herein, and the explanation of above example is only applicable to help to understand the principle of the embodiment of the present invention；Simultaneously for one of ordinary skill in the art, according to the embodiment of the present invention, all will change in detailed description of the invention and range of application, in sum, this specification content should not be construed as limitation of the present invention.
Claims (4)
1. a sterilizing handwashing liquid, it is characterised in that: mainly include following components, be by mass percentage:
2. sterilizing handwashing liquid according to claim 1, mainly includes following components, is by mass percentage:
3. the preparation method of a sterilizing handwashing liquid according to claim 1, it is characterized in that: comprise the following steps: weigh after hydroxypropyl methylcellulose dissolves in the purified water of 1/3, it is sequentially added into after cocamido propyl betaine, cocamidopropyl propyl amide amine oxide, alkyl polyglucoside and glycerol is sufficiently mixed, after regulating pH to 5.5-6.5 with acid-base modifier, after adding Polyhaxemethylenguanidine Hydrochloride and Deciquam mixing, add sodium chloride and regulate denseness, after adding essence, add remaining purified water to stir, obtain product.
4. the preparation method of sterilizing handwashing liquid according to claim 3, it is characterised in that: described acid-base modifier is the sodium hydroxide solution of 1%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610214332.9A CN105769608A (en) | 2016-04-07 | 2016-04-07 | Sterilization and disinfection hand sanitizer and preparation method thereof |
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| CN201610214332.9A CN105769608A (en) | 2016-04-07 | 2016-04-07 | Sterilization and disinfection hand sanitizer and preparation method thereof |
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| CN201610214332.9A Pending CN105769608A (en) | 2016-04-07 | 2016-04-07 | Sterilization and disinfection hand sanitizer and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106388666A (en) * | 2016-08-30 | 2017-02-15 | 杭州国光旅游用品有限公司 | Degreasing wet tissue and preparation method thereof |
| CN108403465A (en) * | 2018-04-19 | 2018-08-17 | 山东顺皓聚氨酯保温材料有限公司 | A kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser and preparation method thereof |
| CN110876684A (en) * | 2019-11-29 | 2020-03-13 | 吉林师范大学 | Preparation method of washing-free polyhexamethylene guanidine hydrochloride disinfectant |
| CN111281879A (en) * | 2020-03-18 | 2020-06-16 | 成都斯瑞宁科技有限公司 | Wound disinfectant |
| CN111743793A (en) * | 2020-08-03 | 2020-10-09 | 默秀平 | Hand sanitizer and preparation method thereof |
| CN112618401A (en) * | 2021-01-15 | 2021-04-09 | 刘长德 | Shampoo special for pets and preparation method thereof |
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| CN101810186A (en) * | 2010-05-18 | 2010-08-25 | 北京绿伞化学股份有限公司 | Multifunctional disinfectant and preparation method thereof |
| CN102018634A (en) * | 2009-09-17 | 2011-04-20 | 上海利康消毒高科技有限公司 | Compound polyhexamethylene guanidine antibacterial hand sanitizer and preparation method |
| CN103948520A (en) * | 2014-04-28 | 2014-07-30 | 辽宁科技大学 | Guanidyl composite disinfection and cleaning hand sanitizer and preparation method for same |
| CN104490630A (en) * | 2014-12-09 | 2015-04-08 | 南阳市汇博生物技术有限公司 | No-washing foam hand disinfection solution and preparation method thereof |
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2016
- 2016-04-07 CN CN201610214332.9A patent/CN105769608A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102018634A (en) * | 2009-09-17 | 2011-04-20 | 上海利康消毒高科技有限公司 | Compound polyhexamethylene guanidine antibacterial hand sanitizer and preparation method |
| CN101810186A (en) * | 2010-05-18 | 2010-08-25 | 北京绿伞化学股份有限公司 | Multifunctional disinfectant and preparation method thereof |
| CN103948520A (en) * | 2014-04-28 | 2014-07-30 | 辽宁科技大学 | Guanidyl composite disinfection and cleaning hand sanitizer and preparation method for same |
| CN104490630A (en) * | 2014-12-09 | 2015-04-08 | 南阳市汇博生物技术有限公司 | No-washing foam hand disinfection solution and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106388666A (en) * | 2016-08-30 | 2017-02-15 | 杭州国光旅游用品有限公司 | Degreasing wet tissue and preparation method thereof |
| CN108403465A (en) * | 2018-04-19 | 2018-08-17 | 山东顺皓聚氨酯保温材料有限公司 | A kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser and preparation method thereof |
| CN110876684A (en) * | 2019-11-29 | 2020-03-13 | 吉林师范大学 | Preparation method of washing-free polyhexamethylene guanidine hydrochloride disinfectant |
| CN111281879A (en) * | 2020-03-18 | 2020-06-16 | 成都斯瑞宁科技有限公司 | Wound disinfectant |
| CN111743793A (en) * | 2020-08-03 | 2020-10-09 | 默秀平 | Hand sanitizer and preparation method thereof |
| CN112618401A (en) * | 2021-01-15 | 2021-04-09 | 刘长德 | Shampoo special for pets and preparation method thereof |
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Application publication date: 20160720 |