CN102018634A - Compound polyhexamethylene guanidine antibacterial hand sanitizer and preparation method - Google Patents
Compound polyhexamethylene guanidine antibacterial hand sanitizer and preparation method Download PDFInfo
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- CN102018634A CN102018634A CN2009101958271A CN200910195827A CN102018634A CN 102018634 A CN102018634 A CN 102018634A CN 2009101958271 A CN2009101958271 A CN 2009101958271A CN 200910195827 A CN200910195827 A CN 200910195827A CN 102018634 A CN102018634 A CN 102018634A
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Abstract
The invention relates to an antibacterial hand sanitizer containing polyhexamethylene guanidine, in particular to a compound polyhexamethylene guanidine antibacterial hand sanitizer. The compound polyhexamethylene guanidine antibacterial hand sanitizer is characterized in that: the antibacterial hand sanitizer comprises the following ingredients by weight percentage: 0.1-1.0 of PHMB (polyhexamethylene biguanidine), 0.1-0.5 of cationic surface active agent, 0.5-1.0 of cellulose, 4.0-7.0 of non-ionic surface active agent, 1.0-3.0 of lipotropic agent, 4.0-8.0 of amphoteric surfactant, 1.0-2.0 of glycerol, 0.5-1.5 of citric acid and the balance water. The preparation method of the antibacterial hand sanitizer comprises the following steps: enough water is added in an agitated reactor, and the temperature is heated to 60-80 DEG C, cellulose is added in water under stirring, after the cellulose is completely swelled, the non-ionic surface active agent, the lipotropic agent, the amphoteric surfactant and the glycerol are sequentially added, after the mixture is mixed evenly, bromogeramine and the PHMB are added and are stirred for five minutes, when the temperature of a feed liquid in the agitated reactor is reduced to room temperature, a proper amount of citric acid is added to adjust the pH value of the feed liquid to be neutral, and filling can be carried out on the mixture subjected to standing and defoaming. In the antibacterial hand sanitizer provided by the invention, a cationic surface active agent is compounded as a sterilization ingredient and has synergy function, and the antibacterial hand sanitizer is used for washing easily without irritation.
Description
Technical field
The present invention relates to handwashing liquid, relate in particular to the anti-bacterial hand lotion that contains polyhexamethylene guanidine.
Background technology
Anti-bacterial hand lotion in the market all adopts DP300 (triclosan), and PX (4-chloro-3,5-xylenols) makes antibacterial, and kind is more single, uses for a long time, easily produces drug resistance.And DP300 and PX poorly water-soluble, the preparation difficulty is big, adopt the handwashing liquid of these two kinds of disinfectant all must add pigment, otherwise handwashing liquid is easy to change after depositing a period of time.
Polyhexamethylene guanidine (PHMB) is the polymer of hydrogen chlorine (hexamethylene biguan-ide), and it is a kind of wide spectrum new type bactericide fast, is used as sterilization, antibiotic and anti-corrosion composition in specialty sterilization and household products.But the PHMB snap action is in antibacterial, virus and pathogen, its model of action comprises following several approach: attract fast and near the surface of antibacterial, receptor one side on the surface is sticked, mechanism is repelled in the defence that overcomes antibacterial, attract near cytoplasma membrane, low-molecular-weight Cytoplasm composition is revealed as K
+, the elimination film extensively destroys cytoplasma membrane to the binding force of enzyme, makes the macromolecule composition reveal as nucleoside the precipitation cell inclusion.So far the less skin degerming that is used for is preserved in the sterilization that is mainly used in the sterilization of swimming-pool water both at home and abroad or is used for invisible glasses.Why situation like this appears, be because: in the general handwashing liquid with anion surfactant as main active matter, the thickening of usefulness sodium chloride gets final product then.And polyhexamethylene guanidine is cationic, with anion surfactant incompatibility is arranged.The handwashing liquid of making antibacterial with polyhexamethylene guanidine just can not have anion surfactant like this.
Summary of the invention
The present invention is intended to address the deficiencies of the prior art, and a kind of compound polyhexamethylene guanidine anti-bacterial hand lotion is provided.Handwashing liquid of the present invention, composite cationic surfactant, Synergistic is easy to clean, and does not have zest.
The present invention is achieved in that
A kind of compound polyhexamethylene guanidine anti-bacterial hand lotion is characterized in that, it comprises (by weight percentage):
PHMB0.1-1.0，
Cationic surfactant 0.1-0.5,
Cellulose 0.5-1.0,
Non-ionic surface active agent 4.0-7.0,
Compose fat agent 1.0-3.0,
Zwitterionic surfactant 4.0-8.0,
Glycerol 1.0-2.0,
Citric acid 0.5-1.5,
All the other are water.
Described compound polyhexamethylene guanidine anti-bacterial hand lotion, described cationic surfactant are selected from a kind of in bromo geramine/geramine; Cellulose is selected from a kind of in hydroxyethyl-cellulose/hydroxypropyl cellulose, non-ionic surface active agent be selected from a kind of, zwitterionic surfactant in fatty alcohol-polyoxyethylene ether/fatty acid diethanolamine/alkyl polyglucoside be selected from the betanin series a kind of, compose the fat agent and be selected from a kind of in polyoxyethylene (7) glyceryl cocoate/lanolin isohexadecyl ether 75.
The preparation method of described compound polyhexamethylene guanidine anti-bacterial hand lotion, it comprises reactor and electric heater that a band stirs, and preparation process is: the water that adds capacity in reactor, heat temperature raising to 60～80 ℃, under agitation add cellulose, after treating its complete swelling, add non-ionic surface active agent successively, compose the fat agent, zwitterionic surfactant, glycerol, add bromo geramine behind the mixing again, PHMB, stirred 5 minutes, when the feed liquid of reactor is reduced to room temperature, an amount of citric acid of reuse regulate feed liquid to pH value to neutral, get final product fill after leaving standstill froth breaking.
The preparation method of described compound polyhexamethylene guanidine anti-bacterial hand lotion, its complete swelling time is 60 minutes behind the described adding hydroxyethyl-cellulose.
The preparation method of described compound polyhexamethylene guanidine anti-bacterial hand lotion, the pH value that described citric acid is regulated feed liquid is 6-7.
Handwashing liquid of the present invention has three big advantages: the one, PHMB is used for skin degerming, composite cationic surfactant, Synergistic, not only strengthen the bactericidal effect, and added cationic surfactant in the prescription, more increased the stability and the dirt-removing power of handwashing liquid, soft and smooth sensation has been arranged after the rinsing.
The 2nd, easy cleaning, non-stimulated to skin.Because the present invention has adopted the biguanides disinfectant, so do not have anion surfactant (incompatibility is arranged) in the prescription, so very big reduction handwashing liquid is to the zest of skin.Adopted nonionic and zwitterionic surfactant in the prescription, thus the foam exquisiteness that handwashing liquid is produced, easy cleaning.Can shorten the time of washing one's hands like this, particularly important concerning the doctors and nurses that need wash one's hands repeatedly every day.
The 3rd, handwashing liquid of the present invention need not add dyestuff and essence owing to used PHMB and bromo geramine to make antibacterial, and the product character is a colourless transparent liquid, and fragrant Semen Armeniacae Amarum flavor is arranged, and long-term storage is invariant color also, uses the back to make skin leave aromatic odor in long-time.
The specific embodiment
The premium properties of PHMB is summarized and is mainly contained 5 points:
1. under low dosage, has broad spectrum of activity, it is 1ppm to the MICs of staphylococcus aureus, is 5ppm to colibacillary MICs, is 100ppm to the MICs of bacillus pyocyaneus, MICs to legionella is 200ppm, only is 20ppm～500ppm. to various funguses and saccharomycetic MICs.
2. have a kind of unspecific sterilization and antibacterial pattern, this shows that antibacterial is difficult for developing immunity to drugs.
3. in hard water, have excellent activity, Organic substance (as protein, fat, blood etc.) is had good tolerance.
4. the scope at pH value (1～11) has good stable and activity.
5. long action time has no side effect.PHMB is difficult for by skin absorbs very much, under conventional working concentration, and extremely low skin and eye irritation.
The present invention is a kind of compound polyhexamethylene guanidine anti-bacterial hand lotion, and it comprises (by weight percentage):
PHMB0.1-1.0，
Cationic surfactant 0.1-0.5,
Cellulose 0.5-1.0,
Non-ionic surface active agent 4.0-7.0,
Compose fat agent 1.0-3.0,
Zwitterionic surfactant 4.0-8.0,
Glycerol 1.0-2.0,
Citric acid 0.5-1.5,
All the other are water.
Described cationic surfactant is selected from a kind of in bromo geramine/geramine; Cellulose is selected from a kind of in hydroxyethyl-cellulose/hydroxypropyl cellulose, non-ionic surface active agent be selected from a kind of, zwitterionic surfactant in fatty alcohol-polyoxyethylene ether/fatty acid diethanolamine/alkyl polyglucoside be selected from the betanin series a kind of, compose the fat agent and be selected from a kind of in polyoxyethylene (7) glyceryl cocoate/lanolin isohexadecyl ether 75.
The preparation process of handwashing liquid of the present invention is very simple, and weak point consuming time is easy to operate, and is simultaneously low for equipment requirements, and reactor and an electric heater of a band stirring get final product.Concrete preparation process is: the water that adds capacity in reactor, heat temperature raising to 60～80 ℃, under agitation add cellulose, (need 60 minutes approximately) after treating its complete swelling, add non-ionic surface active agent successively, compose fat agent, non-ionic surface active agent, wetting agent, add cationic surfactant, PHMB behind the mixing again, stirred 5 minutes, when the feed liquid of reactor is reduced to room temperature, an amount of citric acid of reuse regulate feed liquid to pH value to neutral, get final product fill after leaving standstill froth breaking.
The present invention has enriched handwashing liquid market, provides a kind of new selection to users.
Example 1:PHMB 0.2, bromo geramine 0.2, hydroxyethyl-cellulose 1.0, fatty acid diethanolamine 5.0, polyoxyethylene (7) glyceryl cocoate 4.0, cocamido propyl betaine 10.0, glycerol 2.0, citric acid 0.5-1.5, all the other are water.
Example 2:PHMB 0.3, geramine 0.2, hydroxypropyl cellulose 1.0, fatty alcohol-polyoxyethylene ether 5.0, polyoxyethylene (7) glyceryl cocoate 4.0, cocamido propyl betaine 8.0, propylene glycol 2.0, citric acid 0.5-1.5, all the other are water.
Example 3:PHMB 0.4, bromo geramine 0.2, hydroxyethyl-cellulose 0.8, fatty acid diethanolamine 5.0, (lanolin isohexadecyl ether 7502.0, cocamido propyl betaine 10.0, glycerol 2.0, citric acid 0.5-1.5, all the other are water.
Make finished product by the proportioning of above-mentioned three embodiment according to the preparation method of described handwashing liquid and carry out bactericidal effect, the bactericidal effect of each embodiment sees Table 1:
Table 1 bactericidal effect table
| The kind of microorganism | Antibacterial | Kill the time, min | Killing rate, % |
| Escherichia coli (8099) | Example 1 sample stock solution | 3 | 99.04 |
| Example 2 sample stock solutions | 3 | 99.44 | |
| Example 3 sample stock solutions | 3 | 99.98 | |
| Staphylococcus aureus (ATCC 6538) | Example 1 sample stock solution | 3 | 99.10 |
| Example 2 sample stock solutions | 3 | 99.52 |
| Example 3 sample stock solutions | 3 | 99.97 | |
| Candida albicans (ATCC 10231) | Example 1 sample stock solution | 3 | 99.09 |
| Example 2 sample stock solutions | 3 | 99.43 | |
| Example 3 sample stock solutions | 3 | 99.95 | |
| Bacillus pyocyaneus (ATCC 15442) | Example 1 sample stock solution | 3 | 99.04 |
| Example 2 sample stock solutions | 3 | 99.58 | |
| Example 3 sample stock solutions | 3 | 99.97 |
Claims (5)
1. a compound polyhexamethylene guanidine anti-bacterial hand lotion is characterized in that, it comprises (by weight percentage):
PHMB0.1-1.0，
Cationic surfactant 0.1-0.5,
Cellulose 0.5-1.0,
Non-ionic surface active agent 4.0-7.0,
Compose fat agent 1.0-3.0,
Zwitterionic surfactant 4.0-8.0,
Glycerol 1.0-2.0,
Citric acid 0.5-1.5,
All the other are water.
2. compound polyhexamethylene guanidine anti-bacterial hand lotion according to claim 1 is characterized in that, described cationic surfactant is selected from a kind of in bromo geramine/geramine; Cellulose is selected from a kind of in hydroxyethyl-cellulose/hydroxypropyl cellulose; Non-ionic surface active agent is selected from a kind of in fatty alcohol-polyoxyethylene ether/fatty acid diethanolamine/alkyl polyglucoside; Zwitterionic surfactant is selected from a kind of in the betanin series; Compose the fat agent and be selected from a kind of in polyoxyethylene (7) glyceryl cocoate/lanolin isohexadecyl ether 75.
3. the preparation method of compound polyhexamethylene guanidine anti-bacterial hand lotion according to claim 1, it is characterized in that, it comprises reactor and electric heater that a band stirs, and preparation process is: the water that adds capacity in reactor, heat temperature raising to 60～80 ℃, under agitation add cellulose, after treating its complete swelling, add non-ionic surface active agent successively, compose the fat agent, zwitterionic surfactant, glycerol, add bromo geramine behind the mixing again, PHMB stirred 5 minutes, when the feed liquid of reactor is reduced to room temperature, the an amount of citric acid of reuse regulate feed liquid to pH value to neutral, get final product fill after leaving standstill froth breaking.
4. the preparation method of compound polyhexamethylene guanidine anti-bacterial hand lotion according to claim 3 is characterized in that, its complete swelling time is 60 minutes behind the described adding hydroxyethyl-cellulose.
5. the preparation method of compound polyhexamethylene guanidine anti-bacterial hand lotion according to claim 3 is characterized in that, the pH value that described citric acid is regulated feed liquid is 6-7.
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948520A (en) * | 2014-04-28 | 2014-07-30 | 辽宁科技大学 | Guanidyl composite disinfection and cleaning hand sanitizer and preparation method for same |
| CN105769608A (en) * | 2016-04-07 | 2016-07-20 | 成都蓝孚科技有限公司 | Sterilization and disinfection hand sanitizer and preparation method thereof |
| CN108403465A (en) * | 2018-04-19 | 2018-08-17 | 山东顺皓聚氨酯保温材料有限公司 | A kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser and preparation method thereof |
| CN108904315A (en) * | 2018-08-06 | 2018-11-30 | 郑州吉尔康消毒制品有限公司 | A kind of foam type hand sanitizing fluid and preparation method thereof |
| CN110876684A (en) * | 2019-11-29 | 2020-03-13 | 吉林师范大学 | Preparation method of washing-free polyhexamethylene guanidine hydrochloride disinfectant |
| CN111264566A (en) * | 2020-03-06 | 2020-06-12 | 吉林云飞医药有限公司 | Household disinfectant and preparation method thereof |
| CN111281879A (en) * | 2020-03-18 | 2020-06-16 | 成都斯瑞宁科技有限公司 | Wound disinfectant |
| CN112088879A (en) * | 2020-10-19 | 2020-12-18 | 武汉东湖星科技有限公司 | Quaternary ammonium salt compound disinfectant and preparation method thereof |
| CN112205432A (en) * | 2020-09-27 | 2021-01-12 | 杭州氢态生物科技有限公司 | Cationic composite disinfectant based on plant antibacterial extract |
| US11116220B2 (en) | 2017-12-22 | 2021-09-14 | Ecolab Usa Inc. | Antimicrobial compositions with enhanced efficacy |
| WO2023143490A1 (en) * | 2022-01-28 | 2023-08-03 | Nano And Advanced Materials Institute Limited | Antimicrobial compositions with enhanced efficacy and prolonged performance lifetime, and preparation method thereof |
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2009
- 2009-09-17 CN CN2009101958271A patent/CN102018634A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948520A (en) * | 2014-04-28 | 2014-07-30 | 辽宁科技大学 | Guanidyl composite disinfection and cleaning hand sanitizer and preparation method for same |
| CN105769608A (en) * | 2016-04-07 | 2016-07-20 | 成都蓝孚科技有限公司 | Sterilization and disinfection hand sanitizer and preparation method thereof |
| US11116220B2 (en) | 2017-12-22 | 2021-09-14 | Ecolab Usa Inc. | Antimicrobial compositions with enhanced efficacy |
| US11930819B2 (en) | 2017-12-22 | 2024-03-19 | Ecolab Usa Inc. | Antimicrobial compositions with enhanced efficacy |
| CN108403465A (en) * | 2018-04-19 | 2018-08-17 | 山东顺皓聚氨酯保温材料有限公司 | A kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser and preparation method thereof |
| CN108904315A (en) * | 2018-08-06 | 2018-11-30 | 郑州吉尔康消毒制品有限公司 | A kind of foam type hand sanitizing fluid and preparation method thereof |
| CN110876684A (en) * | 2019-11-29 | 2020-03-13 | 吉林师范大学 | Preparation method of washing-free polyhexamethylene guanidine hydrochloride disinfectant |
| CN111264566A (en) * | 2020-03-06 | 2020-06-12 | 吉林云飞医药有限公司 | Household disinfectant and preparation method thereof |
| CN111281879A (en) * | 2020-03-18 | 2020-06-16 | 成都斯瑞宁科技有限公司 | Wound disinfectant |
| CN112205432A (en) * | 2020-09-27 | 2021-01-12 | 杭州氢态生物科技有限公司 | Cationic composite disinfectant based on plant antibacterial extract |
| CN112088879A (en) * | 2020-10-19 | 2020-12-18 | 武汉东湖星科技有限公司 | Quaternary ammonium salt compound disinfectant and preparation method thereof |
| CN112088879B (en) * | 2020-10-19 | 2021-10-26 | 武汉东湖星科技有限公司 | Quaternary ammonium salt compound disinfectant and preparation method thereof |
| WO2023143490A1 (en) * | 2022-01-28 | 2023-08-03 | Nano And Advanced Materials Institute Limited | Antimicrobial compositions with enhanced efficacy and prolonged performance lifetime, and preparation method thereof |
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Application publication date: 20110420 |