CN111743793A - Hand sanitizer and preparation method thereof - Google Patents
Hand sanitizer and preparation method thereof Download PDFInfo
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- CN111743793A CN111743793A CN202010766002.7A CN202010766002A CN111743793A CN 111743793 A CN111743793 A CN 111743793A CN 202010766002 A CN202010766002 A CN 202010766002A CN 111743793 A CN111743793 A CN 111743793A
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- water
- hand sanitizer
- benzene sulfonate
- alkyl benzene
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- 238000002360 preparation method Methods 0.000 title abstract description 7
- 239000010703 silicon Substances 0.000 claims abstract description 73
- 229910052710 silicon Inorganic materials 0.000 claims abstract description 73
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- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 45
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 45
- 239000011734 sodium Substances 0.000 claims abstract description 40
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 40
- 229940077388 benzenesulfonate Drugs 0.000 claims abstract description 38
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a hand sanitizer which is prepared from the following components in percentage by weight: 0.3-0.6% of hydroxypropyl methyl cellulose, 3-6% of sodium alkyl benzene sulfonate, 3-6% of sodium laureth sulfate, 1-4% of coconut oil diethanolamide, 3-6% of water-soluble silicon, 0.1-0.3% of preservative, 0.1-0.3% of essence and the balance of water. The invention also provides a preparation method of the hand sanitizer. The hand sanitizer provided by the invention can be used for decontamination and sterilization, has the effects of diminishing inflammation and regenerating and repairing wounded skin, and solves the problems that the hand sanitizer in the current market only can be used for decontamination and does not have the effects of sterilization, disinfection and other effects.
Description
Technical Field
The invention relates to the technical field of washing daily chemical products, in particular to a hand sanitizer and a preparation method thereof.
Background
In the daily activities of people, hands contact with various things and the adhered stains are various, so that hand washing is the most frequent action in daily sanitary cleaning life of people, and hand washing products are produced at present. However, due to the restrictions of living conditions and markets, perfumed soaps, washing powders and the like are commonly used for washing hands of people before, and although the perfumed soaps, the washing powders and the like can achieve a certain cleaning effect, the perfumed soaps have an irritant effect on the skin, and after long-term use, part of the skin is rough, chapped and peeled.
The hand sanitizer is a common washing product, and is popular with consumers due to the characteristics of convenient use and convenient preservation. The common hand sanitizer can only decontaminate, has limited killing effect on bacteria and viruses, and has the functions of diminishing inflammation and regenerating and repairing skin wounds.
Therefore, aiming at the defects of the hand sanitizer products in the current market, the invention provides a novel hand sanitizer with the functions of sterilization, decontamination, inflammation diminishing and the like.
Disclosure of Invention
The invention aims to provide a hand sanitizer and a preparation method thereof, wherein the hand sanitizer has excellent permeability, bactericidal property and cleaning ability, has the anti-inflammatory and regenerative repair capabilities on skin wounds, and solves the problems that the hand sanitizer in the current market only can decontaminate and does not have the functions of sterilization, disinfection, anti-inflammatory and regenerative repair on the skin wounds.
The invention provides a hand sanitizer which is prepared from the following components in percentage by weight:
0.3-0.6% of hydroxypropyl methyl cellulose, 3-6% of sodium alkyl benzene sulfonate, 3-6% of sodium laureth sulfate, 1-4% of coconut oil diethanolamide, 3-6% of water-soluble silicon, 0.1-0.3% of preservative, 0.1-0.3% of essence and the balance of water.
The water soluble silicon is water soluble silicon crystal solution formed by dissolving silicon trioxide in water, and has the chemical characteristics of no radioactivity, no explosiveness, no toxicity, no sterility and the like. The water-soluble silicon element contained in the water-soluble silicon has super-strong permeability, and the water-soluble silicon element has fine molecules of about 0.4 nanometer, so that the water-soluble silicon element can quickly permeate into cells and has extremely strong permeability to skin. The water-soluble silicon element has super-strong bactericidal property and is mainly reflected in having strong instant bactericidal effect on escherichia coli and legionella (gram-negative bacteria). The water-soluble silicon element has super-strong anti-inflammatory power and has the function of strongly preventing the development of cell inflammation. Can quickly diminish inflammation of damaged skin tissues, such as injured wounds, scalds, burns, frostbites and the like, and can quickly relieve pain and quickly recover the damaged tissues by coating the affected parts with the soluble silicon element. The water-soluble silicon element has super strong cleaning power, can quickly decompose greasy dirt residues on hands when the hands are washed by the liquid soap containing the silicon element, and has extremely strong purification and cleaning effects. The water-soluble silicon element has super strong regenerative power, and can repair and activate damaged cell tissues, skin tissues and connective tissues to promote the regeneration of the damaged cell tissues, skin tissues and connective tissues.
The hydroxypropyl methyl cellulose not only has the characteristics of salt resistance, pH stability, water retention property, dimensional stability, excellent film forming property, wide enzyme resistance, dispersibility, cohesiveness and the like, but also has thickening capability and plays a role in thickening in the invention. The hydrophobic main chain of the cellulose thickener molecules contained in the hydroxypropyl methyl cellulose can be associated with the surrounding water molecules through hydrogen bonds, so that the fluid volume of the polymer is increased, the free movement space of particles is reduced, and the viscosity of the system is increased.
The sodium alkyl benzene sulfonate is solid and soluble in water, has active matter content of 30-40%, unsaponifiable matter content of 3%, pH value of about 8, and has the surface activity of cleaning, moistening, foaming, emulsifying and dispersing. Sodium alkyl benzene sulfonate is easy to oxidize, strong in foaming power, high in detergency, easy to compound with various assistants, low in cost, mature in synthesis process and very excellent in anionic surfactant. The sodium alkyl benzene sulfonate has obvious detergency effect on granular dirt, protein dirt and oily dirt, excellent detergency on granular dirt on natural fiber, raised detergency with the raised washing temperature, high protein dirt effect and rich foam.
Sodium laureth sulfate is a white or pale yellow gel paste or a colorless or pale yellow liquid. From the structure, the sodium laureth sulfate belongs to an amphoteric surfactant, but the sodium sulfate group is dominant, so the sodium laureth sulfate belongs to an anionic type, can be dissolved in water and alcohol, has good washing performance and diffusivity, is easy to generate a large amount of foam, and has antistatic property, smoothness, softness and strong detergency.
The coconut oil diethanolamide has good thickening, foam increasing and foam stabilizing properties; has good emulsifying and decontaminating capabilities; the surfactant has good combination and synergistic effect with other surfactants; has the performances of static resistance, rust prevention, corrosion prevention and the like.
The preservative may inhibit the growth of bacteria, fungi, mold and mildew in the hand sanitizer.
The essence has the main function of generating pleasant smell in the hand sanitizer provided by the invention and covering the smell of a product substrate.
The hand sanitizer prepared from the raw materials can remove dirt on hand skin and kill germs on the surface of the skin. Moreover, the hand sanitizer has an anti-inflammatory effect on a wound part of skin, and can promote regeneration of skin tissues and repair damaged skin.
Further, the hand sanitizer is prepared from the following components in percentage by weight:
0.4 to 0.5 percent of hydroxypropyl methyl cellulose, 4 to 5 percent of sodium alkyl benzene sulfonate, 4 to 5 percent of sodium laureth sulfate, 2 to 3 percent of coconut oil diethanolamide, 4 to 5 percent of water-soluble silicon, 0.1 to 0.2 percent of preservative, 0.1 to 0.2 percent of essence and the balance of water.
The hand sanitizer prepared from the components in percentage by weight has the remarkable effects of decontaminating, sterilizing and diminishing inflammation and regenerating and repairing wounded skin.
Further, the preservative is methylisothiazolinone. Methylisothiazolinone is a high-efficiency bactericide, a heat-resistant aqueous preservative, has a good effect on inhibiting the growth of microorganisms, and can inhibit the growth of bacteria, fungi, molds and mildew.
Further, the water is deionized water.
Deionized water refers to pure water from which impurities in the form of ions are removed, and the water quality is more pure.
The invention also provides a preparation method of the hand sanitizer, which comprises the following steps:
s1: dissolving hydroxypropyl methylcellulose in water to obtain a hydroxypropyl methylcellulose solution;
s2: adding sodium alkyl benzene sulfonate into the hydroxypropyl methyl cellulose solution, stirring until the sodium alkyl benzene sulfonate is completely dissolved, adding a sodium hydroxide solution into the mixture, and adjusting the pH value to 6-8 to obtain a mixed solution 1;
s3: adding sodium laureth sulfate into the mixed solution 1, and stirring until the sodium laureth sulfate is dissolved to obtain a mixed solution 2;
s4: adding coconut oil diethanolamide, water-soluble silicon, preservative and essence into the mixed solution 2, and uniformly stirring to obtain the hand sanitizer.
The hydroxypropyl methyl cellulose solution obtained in the step S1 can increase the viscosity of the hand sanitizer. Step S2, sodium alkyl benzene sulfonate is added, so that the hand sanitizer is easy to foam, and protein dirt and oily dirt can be effectively removed; the pH value is adjusted to be alkalescent by adding sodium hydroxide solution, which is beneficial to enhancing the dirt-removing capability of the hand sanitizer because sweat secreted by a human body is acidic, and dirt on skin is acidic generally due to inorganic salt separated out along with the sweat and grease secreted on the skin surface. In step S3, the stirring process of sodium laureth sulfate is performed slowly to prevent the generation of bubbles. Through the step S4, the prepared hand sanitizer not only has the functions of removing dirt, sterilizing and promoting the regeneration of damaged skin, but also has pleasant fragrance.
Further, the step S2 specifically includes:
heating hydroxypropyl methylcellulose solution to 44-46 ℃ in water bath, adding sodium alkyl benzene sulfonate, stirring to completely dissolve, adding 1-3% by mass of sodium hydroxide solution, and adjusting pH to 6-8 to obtain mixed solution 1.
Heating in water bath to 44-46 deg.c is favorable to the fast dissolution of sodium alkyl benzene sulfonate. And adding 1-3% by mass of sodium hydroxide solution to effectively adjust the pH value of the mixed solution 1.
Further, the water-soluble silicon is prepared by the following method:
burning the silicon dioxide at 1650-2000 ℃ for 8-10 hours, and rapidly cooling to form silicon crystals; and combining the silicon crystals with water to prepare the water-soluble silicon.
Using high grade silicon dioxide (SiO)2) Recovering gasified silicon element component by 1650-2000 deg.C high-temperature physical extraction method and special method of continuous burning for more than 8 hr, neutralizing harmful component, decomposing, and quickly cooling to form soluble crystal (SiO)3). Soluble crystals (SiO)3) Combined with water, can be dissolved in water body by 100 percent to form ionic free molecules, namely water-soluble silicon.
The hand sanitizer and the preparation method thereof provided by the invention take hydroxypropyl methyl cellulose, sodium alkyl benzene sulfonate, sodium laureth sulfate, coconut oil diethanolamide, water-soluble silicon, a preservative, essence and the like as raw materials, have an ultra-strong cleaning function, and can rapidly decompose oil stain residues on hands. The hand sanitizer provided by the invention has strong bactericidal performance and can instantly kill escherichia coli, legionella and the like. In addition, as the hand sanitizer takes water-soluble silicon as a raw material, the hand sanitizer also has super anti-inflammatory effect and skin regeneration promoting capability.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some schematic drawings of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is a schematic diagram showing the inhibition effect of an aqueous solution of water-soluble silicon crystals on Escherichia coli;
FIG. 2 is a schematic diagram showing the inhibitory effect of an aqueous solution of water-soluble silicon crystals on Vibrio bacteria;
FIG. 3 is a schematic representation of the inhibitory effect of an aqueous solution of water-soluble silicon crystals on Staphylococcus aureus;
FIG. 4 is a schematic diagram showing the inhibitory effect of an aqueous solution of water-soluble crystalline silanols on Aeromonas hydrophila;
FIG. 5 is a schematic representation of the inhibition of Streptococcus agalactiae by an aqueous solution of water-soluble crystalline silanols;
FIG. 6 is a scanning electron microscope image showing the inhibitory effect of a water-soluble silicon crystal aqueous solution on Staphylococcus aureus (including a control group and a treated group, wherein the control group is a scanning electron microscope image showing Staphylococcus aureus without adding the water-soluble silicon crystal aqueous solution, and the control group is a scanning electron microscope image showing Staphylococcus aureus with adding the water-soluble silicon crystal aqueous solution);
FIG. 7 is a scanning electron microscope photograph showing the inhibitory effect of an aqueous solution of water-soluble silicone crystals on Aeromonas hydrophila (including a control group and a treated group), wherein the control group is a scanning electron microscope photograph of Aeromonas hydrophila without the addition of an aqueous solution of water-soluble silicone crystals, and the control group is a scanning electron microscope photograph of Aeromonas hydrophila with the addition of an aqueous solution of water-soluble silicone crystals).
Detailed Description
It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms also include the plural forms unless the context clearly dictates otherwise, and further, it is understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of the stated features, steps, operations, devices, components, and/or combinations thereof.
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A hand sanitizer is prepared from the following components in percentage by weight:
0.3% of hydroxypropyl methyl cellulose, 3% of sodium alkyl benzene sulfonate, 3% of sodium laureth sulfate, 1% of coconut diethanolamide, 3% of water-soluble silicon, 0.1% of preservative, 0.1% of essence and the balance of water.
The hand sanitizer is prepared by the following steps:
s1: dissolving hydroxypropyl methylcellulose in water to obtain a hydroxypropyl methylcellulose solution;
s2: heating a hydroxypropyl methyl cellulose solution in a water bath to 44 ℃, adding sodium alkyl benzene sulfonate, stirring until the sodium alkyl benzene sulfonate is completely dissolved, adding a sodium hydroxide solution with the mass fraction of 1%, and adjusting the pH value to 6 to obtain a mixed solution 1;
s3: adding sodium laureth sulfate into the mixed solution 1, and stirring until the sodium laureth sulfate is dissolved to obtain a mixed solution 2;
s4: adding coconut oil diethanolamide, water-soluble silicon, preservative and essence into the mixed solution 2, and uniformly stirring to obtain the hand sanitizer.
Example 2
A hand sanitizer is prepared from the following components in percentage by weight:
0.45 percent of hydroxypropyl methyl cellulose, 4.5 percent of sodium alkyl benzene sulfonate, 4.5 percent of sodium lauryl polyether sulfate, 2.5 percent of coconut oil diethanolamide, 4.5 percent of water-soluble silicon, 0.2 percent of preservative, 0.2 percent of essence and the balance of water.
The hand sanitizer is prepared by the following steps:
s1: dissolving hydroxypropyl methylcellulose in water to obtain a hydroxypropyl methylcellulose solution;
s2: heating a hydroxypropyl methyl cellulose solution to 45 ℃ in a water bath, adding sodium alkyl benzene sulfonate, stirring until the sodium alkyl benzene sulfonate is completely dissolved, adding a sodium hydroxide solution with the mass fraction of 2%, and adjusting the pH value to 7 to obtain a mixed solution 1;
s3: adding sodium laureth sulfate into the mixed solution 1, and stirring until the sodium laureth sulfate is dissolved to obtain a mixed solution 2;
s4: adding coconut oil diethanolamide, water-soluble silicon, preservative and essence into the mixed solution 2, and uniformly stirring to obtain the hand sanitizer.
Example 3
A hand sanitizer is prepared from the following components in percentage by weight:
0.6% of hydroxypropyl methyl cellulose, 6% of sodium alkyl benzene sulfonate, 6% of sodium laureth sulfate, 4% of coconut diethanolamide, 6% of water-soluble silicon, 0.3% of preservative, 0.3% of essence and the balance of water.
The hand sanitizer is prepared by the following steps:
s1: dissolving hydroxypropyl methylcellulose in water to obtain a hydroxypropyl methylcellulose solution;
s2: heating a hydroxypropyl methyl cellulose solution to 46 ℃ in a water bath, adding sodium alkyl benzene sulfonate, stirring until the sodium alkyl benzene sulfonate is completely dissolved, adding a sodium hydroxide solution with the mass fraction of 3%, and adjusting the pH value to 8 to obtain a mixed solution 1;
s3: adding sodium laureth sulfate into the mixed solution 1, and stirring until the sodium laureth sulfate is dissolved to obtain a mixed solution 2;
s4: adding coconut oil diethanolamide, water-soluble silicon, preservative and essence into the mixed solution 2, and uniformly stirring to obtain the hand sanitizer.
Example 4
A hand sanitizer is prepared from the following components in percentage by weight:
0.4% of hydroxypropyl methyl cellulose, 4% of sodium alkyl benzene sulfonate, 4% of sodium lauryl polyether sulfate, 2% of coconut diethanolamide, 4% of water-soluble silicon, 0.1% of preservative, 0.1% of essence and the balance of water.
The hand sanitizer is prepared by the following steps:
s1: dissolving hydroxypropyl methylcellulose in water to obtain a hydroxypropyl methylcellulose solution;
s2: heating a hydroxypropyl methyl cellulose solution in a water bath to 44 ℃, adding sodium alkyl benzene sulfonate, stirring until the sodium alkyl benzene sulfonate is completely dissolved, adding a sodium hydroxide solution with the mass fraction of 1%, and adjusting the pH value to 6 to obtain a mixed solution 1;
s3: adding sodium laureth sulfate into the mixed solution 1, and stirring until the sodium laureth sulfate is dissolved to obtain a mixed solution 2;
s4: adding coconut oil diethanolamide, water-soluble silicon, preservative and essence into the mixed solution 2, and uniformly stirring to obtain the hand sanitizer.
Example 5
A hand sanitizer is prepared from the following components in percentage by weight:
0.5% of hydroxypropyl methyl cellulose, 5% of sodium alkyl benzene sulfonate, 5% of sodium laureth sulfate, 3% of coconut oil diethanol amide, 5% of water-soluble silicon, 0.2% of preservative, 0.2% of essence and the balance of water.
The hand sanitizer is prepared by the following steps:
s1: dissolving hydroxypropyl methylcellulose in water to obtain a hydroxypropyl methylcellulose solution;
s2: heating a hydroxypropyl methyl cellulose solution to 45 ℃ in a water bath, adding sodium alkyl benzene sulfonate, stirring until the sodium alkyl benzene sulfonate is completely dissolved, adding a sodium hydroxide solution with the mass fraction of 2%, and adjusting the pH value to 7 to obtain a mixed solution 1;
s3: adding sodium laureth sulfate into the mixed solution 1, and stirring until the sodium laureth sulfate is dissolved to obtain a mixed solution 2;
s4: adding coconut oil diethanolamide, water-soluble silicon, preservative and essence into the mixed solution 2, and uniformly stirring to obtain the hand sanitizer.
Example 6
A hand sanitizer is prepared from the following components in percentage by weight:
0.5% of hydroxypropyl methyl cellulose, 5% of sodium alkyl benzene sulfonate, 5% of sodium laureth sulfate, 3% of coconut oil diethanol amide, 5% of water-soluble silicon, 0.2% of preservative, 0.2% of essence and the balance of water.
The hand sanitizer is prepared by the following steps:
s1: dissolving hydroxypropyl methylcellulose in water to obtain a hydroxypropyl methylcellulose solution;
s2: heating a hydroxypropyl methyl cellulose solution to 46 ℃ in a water bath, adding sodium alkyl benzene sulfonate, stirring until the sodium alkyl benzene sulfonate is completely dissolved, adding a sodium hydroxide solution with the mass fraction of 3%, and adjusting the pH value to 8 to obtain a mixed solution 1;
s3: adding sodium laureth sulfate into the mixed solution 1, and stirring until the sodium laureth sulfate is dissolved to obtain a mixed solution 2;
s4: adding coconut oil diethanolamide, water-soluble silicon, preservative and essence into the mixed solution 2, and uniformly stirring to obtain the hand sanitizer.
Wherein, the silicon trioxide is prepared by the following method:
burning the silicon dioxide at 1825 ℃ for 9 hours, and rapidly cooling to form silicon crystals; and combining the silicon crystals with water to prepare the water-soluble silicon.
Example 7
A hand sanitizer is prepared from the following components in percentage by weight:
0.5% of hydroxypropyl methyl cellulose, 5% of sodium alkyl benzene sulfonate, 5% of sodium laureth sulfate, 3% of coconut diethanolamide, 5% of water-soluble silicon, 0.2% of methylisothiazolinone, 0.2% of essence and the balance of deionized water.
The hand sanitizer is prepared by the following steps:
s1: adding hydroxypropyl methyl cellulose into deionized water for dissolving to obtain a hydroxypropyl methyl cellulose solution;
s2: heating a hydroxypropyl methyl cellulose solution to 46 ℃ in a water bath, adding sodium alkyl benzene sulfonate, stirring until the sodium alkyl benzene sulfonate is completely dissolved, adding a sodium hydroxide solution with the mass fraction of 3%, and adjusting the pH value to 8 to obtain a mixed solution 1;
s3: adding sodium laureth sulfate into the mixed solution 1, and stirring until the sodium laureth sulfate is dissolved to obtain a mixed solution 2;
s4: adding coconut oil diethanolamide, water-soluble silicon, methylisothiazolinone and essence into the mixed solution 2, and uniformly stirring to obtain the hand sanitizer.
Wherein, the silicon trioxide is prepared by the following method:
burning the silicon dioxide at 2000 ℃ for 10 hours, and quickly cooling to form silicon crystals; and combining the silicon crystals with water to prepare the water-soluble silicon.
According to the trial feedback condition of the volunteers, the hand sanitizer provided by the examples 1-7 is considered to be capable of decontaminating by 100% of the volunteers, and the hand sanitizer provided by the examples 1-7 is considered to have the effects of diminishing inflammation and regenerating and repairing the wounded skin by 98% of the volunteers.
The sterilization and disinfection effects of the hand sanitizer cannot be directly obtained by trial use, and the sterilization and disinfection effects of the hand sanitizer provided by the invention mainly come from a water-soluble silicon crystal aqueous solution formed by dissolving silicon trioxide in water. Accordingly, the present invention provides a schematic representation of the bactericidal inhibition effect of the aqueous solution of water-soluble crystalline silicic acid formed by dissolving the silicon trioxide in water in the figures 1 to 7: wherein, FIG. 1 is a schematic diagram of the inhibition effect of a water-soluble silicon crystal aqueous solution on Escherichia coli; FIG. 2 is a schematic diagram showing the inhibitory effect of an aqueous solution of water-soluble silicon crystals on Vibrio bacteria; FIG. 3 is a schematic representation of the inhibitory effect of an aqueous solution of water-soluble silicon crystals on Staphylococcus aureus; FIG. 4 is a schematic diagram showing the inhibitory effect of an aqueous solution of water-soluble crystalline silanols on Aeromonas hydrophila; FIG. 5 is a schematic representation of the inhibition of Streptococcus agalactiae by an aqueous solution of water-soluble crystalline silanols; FIG. 6 is a scanning electron microscope image showing the inhibitory effect of a water-soluble silicon crystal aqueous solution on Staphylococcus aureus (including a control group and a treated group, wherein the control group is a scanning electron microscope image showing Staphylococcus aureus without adding the water-soluble silicon crystal aqueous solution, and the control group is a scanning electron microscope image showing Staphylococcus aureus with adding the water-soluble silicon crystal aqueous solution); FIG. 7 is a scanning electron microscope photograph showing the inhibitory effect of an aqueous solution of water-soluble silicone crystals on Aeromonas hydrophila (including a control group and a treated group), wherein the control group is a scanning electron microscope photograph of Aeromonas hydrophila without the addition of an aqueous solution of water-soluble silicone crystals, and the control group is a scanning electron microscope photograph of Aeromonas hydrophila with the addition of an aqueous solution of water-soluble silicone crystals).
In conclusion, the bacteriostatic test of the water-soluble silicon crystal aqueous solution shows that the water-soluble silicon crystal aqueous solution with the concentration of 500ppm has a better effect, and the bacteriostatic effect is not very obvious compared with the water-soluble silicon crystal aqueous solution. From the results of scanning electron microscopy, it was found that the water-soluble silicon crystal aqueous solution can destroy the bacterial cell wall, and finally cause the bacterial death.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (7)
1. The hand sanitizer is characterized by being prepared from the following components in percentage by weight:
0.3-0.6% of hydroxypropyl methyl cellulose, 3-6% of sodium alkyl benzene sulfonate, 3-6% of sodium laureth sulfate, 1-4% of coconut oil diethanolamide, 3-6% of water-soluble silicon, 0.1-0.3% of preservative, 0.1-0.3% of essence and the balance of water.
2. The hand sanitizer according to claim 1, which is prepared from the following components in percentage by weight:
0.4 to 0.5 percent of hydroxypropyl methyl cellulose, 4 to 5 percent of sodium alkyl benzene sulfonate, 4 to 5 percent of sodium laureth sulfate, 2 to 3 percent of coconut oil diethanolamide, 4 to 5 percent of water-soluble silicon, 0.1 to 0.2 percent of preservative, 0.1 to 0.2 percent of essence and the balance of water.
3. The hand sanitizer of claim 2, wherein the preservative is methylisothiazolinone.
4. The hand sanitizer of claim 3, wherein the water is deionized water.
5. A method of preparing a hand sanitizer according to any one of claims 1 to 4 comprising the steps of:
s1: dissolving hydroxypropyl methylcellulose in water to obtain a hydroxypropyl methylcellulose solution;
s2: adding sodium alkyl benzene sulfonate into the hydroxypropyl methyl cellulose solution, stirring until the sodium alkyl benzene sulfonate is completely dissolved, adding a sodium hydroxide solution into the mixture, and adjusting the pH value to 6-8 to obtain a mixed solution 1;
s3: adding sodium laureth sulfate into the mixed solution 1, and stirring until the sodium laureth sulfate is dissolved to obtain a mixed solution 2;
s4: adding coconut oil diethanolamide, water-soluble silicon, preservative and essence into the mixed solution 2, and uniformly stirring to obtain the hand sanitizer.
6. The method for preparing a hand sanitizer according to claim 5, wherein the step S2 specifically comprises:
heating hydroxypropyl methylcellulose solution to 44-46 ℃ in water bath, adding sodium alkyl benzene sulfonate, stirring to completely dissolve, adding 1-3% by mass of sodium hydroxide solution, and adjusting pH to 6-8 to obtain mixed solution 1.
7. The method of claim 6, wherein the water soluble silicon is prepared by:
burning the silicon dioxide at 1650-2000 ℃ for 8-10 hours, and rapidly cooling to form silicon crystals; and combining the silicon crystals with water to prepare the water-soluble silicon.
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| CN202010766002.7A CN111743793A (en) | 2020-08-03 | 2020-08-03 | Hand sanitizer and preparation method thereof |
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| CN202010766002.7A CN111743793A (en) | 2020-08-03 | 2020-08-03 | Hand sanitizer and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115778859A (en) * | 2022-12-23 | 2023-03-14 | 李克明 | Skin conditioner |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769608A (en) * | 2016-04-07 | 2016-07-20 | 成都蓝孚科技有限公司 | Sterilization and disinfection hand sanitizer and preparation method thereof |
| CN111228128A (en) * | 2020-02-24 | 2020-06-05 | 华夏瑞天(北京)生物科技有限公司 | Strong-effect degreasing liquid soap containing water-soluble silicon element waste liquid |
-
2020
- 2020-08-03 CN CN202010766002.7A patent/CN111743793A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769608A (en) * | 2016-04-07 | 2016-07-20 | 成都蓝孚科技有限公司 | Sterilization and disinfection hand sanitizer and preparation method thereof |
| CN111228128A (en) * | 2020-02-24 | 2020-06-05 | 华夏瑞天(北京)生物科技有限公司 | Strong-effect degreasing liquid soap containing water-soluble silicon element waste liquid |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115778859A (en) * | 2022-12-23 | 2023-03-14 | 李克明 | Skin conditioner |
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