CN105766901B - A kind of mosquito repellent sustained-release dropping pill and preparation method - Google Patents
A kind of mosquito repellent sustained-release dropping pill and preparation method Download PDFInfo
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- CN105766901B CN105766901B CN201610128201.9A CN201610128201A CN105766901B CN 105766901 B CN105766901 B CN 105766901B CN 201610128201 A CN201610128201 A CN 201610128201A CN 105766901 B CN105766901 B CN 105766901B
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- oil
- essential oil
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- mosquito repellent
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- 239000006187 pill Substances 0.000 title claims abstract description 49
- 239000000077 insect repellent Substances 0.000 title claims abstract description 40
- 238000013268 sustained release Methods 0.000 title claims abstract description 34
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000000341 volatile oil Substances 0.000 claims abstract description 46
- 239000000203 mixture Substances 0.000 claims abstract description 31
- 239000011159 matrix material Substances 0.000 claims abstract description 22
- 239000003921 oil Substances 0.000 claims abstract description 12
- 235000005979 Citrus limon Nutrition 0.000 claims abstract description 11
- 244000131522 Citrus pyriformis Species 0.000 claims abstract description 11
- 239000012141 concentrate Substances 0.000 claims abstract description 11
- 239000010656 jasmine oil Substances 0.000 claims abstract description 11
- 239000008371 vanilla flavor Substances 0.000 claims abstract description 11
- 238000003756 stirring Methods 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 6
- 238000010257 thawing Methods 0.000 claims abstract description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 235000019198 oils Nutrition 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 244000004281 Eucalyptus maculata Species 0.000 claims description 9
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- 238000002844 melting Methods 0.000 claims description 7
- 230000008018 melting Effects 0.000 claims description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims description 7
- 229920000858 Cyclodextrin Polymers 0.000 claims description 6
- 239000001116 FEMA 4028 Substances 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 6
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 6
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 6
- 229960004853 betadex Drugs 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 238000010025 steaming Methods 0.000 claims description 6
- 241000196324 Embryophyta Species 0.000 claims description 5
- 238000004821 distillation Methods 0.000 claims description 5
- 238000000199 molecular distillation Methods 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 4
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical group [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 4
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 3
- 229920002594 Polyethylene Glycol 8000 Polymers 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000004006 olive oil Substances 0.000 claims description 3
- 235000008390 olive oil Nutrition 0.000 claims description 3
- 239000003549 soybean oil Substances 0.000 claims description 3
- 235000012424 soybean oil Nutrition 0.000 claims description 3
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 2
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims description 2
- 229920002538 Polyethylene Glycol 20000 Polymers 0.000 claims description 2
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims description 2
- 229940036350 bisabolol Drugs 0.000 claims description 2
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims description 2
- 239000003240 coconut oil Substances 0.000 claims description 2
- 235000019864 coconut oil Nutrition 0.000 claims description 2
- 239000008157 edible vegetable oil Substances 0.000 claims description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 2
- 229960004889 salicylic acid Drugs 0.000 claims description 2
- 239000008159 sesame oil Substances 0.000 claims description 2
- 235000011803 sesame oil Nutrition 0.000 claims description 2
- 229920002545 silicone oil Polymers 0.000 claims description 2
- 229940032147 starch Drugs 0.000 claims 3
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims 2
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 229930016911 cinnamic acid Natural products 0.000 claims 2
- 235000013985 cinnamic acid Nutrition 0.000 claims 2
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims 2
- AQLLBJAXUCIJSR-UHFFFAOYSA-N OC(=O)C[Na] Chemical compound OC(=O)C[Na] AQLLBJAXUCIJSR-UHFFFAOYSA-N 0.000 claims 1
- 244000290333 Vanilla fragrans Species 0.000 claims 1
- 235000009499 Vanilla fragrans Nutrition 0.000 claims 1
- 235000012036 Vanilla tahitensis Nutrition 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
- 229940080313 sodium starch Drugs 0.000 claims 1
- 241000255925 Diptera Species 0.000 abstract description 5
- 239000000470 constituent Substances 0.000 abstract description 3
- 206010059866 Drug resistance Diseases 0.000 abstract description 2
- 230000001846 repelling effect Effects 0.000 abstract description 2
- 244000166124 Eucalyptus globulus Species 0.000 abstract 2
- 239000000155 melt Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 6
- 230000001139 anti-pruritic effect Effects 0.000 description 3
- 239000003908 antipruritic agent Substances 0.000 description 3
- 239000011505 plaster Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000006071 cream Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000011435 rock Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000256059 Culex pipiens Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 239000010779 crude oil Substances 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000010734 process oil Substances 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/18—Vapour or smoke emitting compositions with delayed or sustained release
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
- A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
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- A61L9/012—Deodorant compositions characterised by being in a special form, e.g. gels, emulsions
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- A—HUMAN NECESSITIES
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- A61L9/00—Disinfection, sterilisation or deodorisation of air
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The present invention relates to a kind of mosquito repellent sustained-release dropping pill and preparation methods, it is characterised in that including essential oil composition and matrix；The weight ratio of the essential oil composition and the matrix is 1:1~1:8；The essential oil composition includes lemon eucalyptus quintessence oil, Herba Lysimachiae foenumgraeci essential oil, vanilla flavour concentrate, refined jasmine oil and synergist.Preparation method is that line melts lemon eucalyptus quintessence oil, and Herba Lysimachiae foenumgraeci essential oil, vanilla flavour concentrate, refined jasmine oil and synergist is then added, stirs evenly；It is added in the matrix of thawing, stirs evenly simultaneously constant temperature；Then dripping pill is prepared by specific technique in pill dripping machine.The present invention can be according to different use requirements with the usage quantity of hobby self assemble dripping pill and using sequentially, to control the single active constituent sustained release amount and sustained release duration of essential oil, mosquito will not be enabled to develop drug resistance, can be used with a variety of mosquito repellent carrier combinations, repelling effect is good.
Description
Technical field
The present invention relates to mosquito repellent product, a kind of mosquito repellent sustained-release dropping pill and preparation method are referred specifically to.
Background technique
Common mosquito repellent product has mosquito-repellent perfume, mosquito repellent liquid, mosquito-dispelling cream, mosquito repellent aerosol, mosquito-repellent liquid, mosquito repellent on the market
Cream, mosquito-dispelling tablet, mosquito expelling plaster, mosquito repellent gel etc..The repellent product for directly acting on skin is likely to cause human body discomfort and allergy
The problems such as, the sustained-release dosage types such as mosquito-dispelling tablet, mosquito expelling plaster are then uncontrollable in the presence of sustained release duration, are not easy to the problems such as quality control；And
For a long time, chemical synthesis repellant largely and is unreasonably used, has produced a series of problem, therefore there is an urgent need to grind
Study carefully and develop health, environmental protection, safe and effective novel mosquito-repellent.
Natural plant essential oils have many advantages, such as renewable, degradable, meet that people are safe and environment-friendly to mosquito-repellent to be wanted
It asks.But readily volatilized since the ingredient of essential oil is more complex, vulnerable to the influence of environmental factor in use process, and crude oil is being smeared
After skin, generally there are the disadvantages of greasy, scorching hot, minority can may also generate shouting pain, be not suitable for directly using.
Summary of the invention
The technical problem to be solved by the present invention is to the statuses for the prior art to provide a kind of sustained release amount and sustained release duration
Controllable mosquito repellent sustained-release dropping pill.
Another technical problem to be solved by this invention be to provide a kind of sustained release amount and sustained release duration it is controllable mosquito repellent it is slow
Release the preparation method of dripping pill.
The technical scheme of the invention to solve the technical problem is: the mosquito repellent sustained-release dropping pill, it is characterised in that packet
Include essential oil composition and matrix；The weight ratio of the essential oil composition and the matrix is 1:1~1:8；The essential oil composition
It is formed including following weight:
The synergist is selected from soybean oil, olive oil, sesame oil, coconut oil, bisabolol, salicylic acid, vanillic aldehyde, cortex cinnamomi
At least one of aldehyde and gaultherolin；The matrix is selected from polyethylene glycol, sodium carboxymethyl starch, beta-cyclodextrin and poly- sorb
At least one of ester -80.
Preferably, the composition of the essential oil composition are as follows:
Preferably, the composition of the essential oil composition are as follows:
In above-mentioned each scheme, the proportion of the preferably described essential oil composition and the matrix is 1:2~1:5.
The matrix is preferably the mixture of Macrogol 4000, Macrogol 6000 and PEG 20000, three's
Mass ratio is 1:1:1.
Alternatively, the matrix is preferably the mixture of Macrogol 4000, polyethylene glycol 12000 and sodium carboxymethyl starch,
The mass ratio of three is 2:1:1.
Alternatively, the matrix is preferably polyethylene glycol 12000, PEG 8000, sodium carboxymethyl starch and beta-cyclodextrin
Mixture, the polyethylene glycol 12000, PEG 8000, beta-cyclodextrin mass ratio be 1:1:0.2:0.2.
The preparation method of mosquito repellent sustained-release dropping pill in above-mentioned each scheme, it is characterised in that include the following steps:
(1) each component is weighed according to the ratio；
(2) in 50 DEG C~70 DEG C heating lemon eucalyptus quintessence oils, until melting completely；In the lemon eucalyptus quintessence oil of thawing
Herba Lysimachiae foenumgraeci essential oil, vanilla flavour concentrate, refined jasmine oil and the synergist is added, stirs evenly；Obtain essential oil composition；
(3) matrix is heated to melting at 75 DEG C~105 DEG C, the essential oil is added after being subsequently cooled to 65~70 DEG C
Composition stirs evenly and keeps 65~70 DEG C of constant temperature；
(4) temperature control system for adjusting pill dripping machine, makes 65 DEG C~95 DEG C of temperature of water dropper；The temperature of condensing agent is 35
DEG C~-5 DEG C；Stably reach above-mentioned state respectively to the temperature of pill dripping machine water dropper and condensing agent, will containing compound plant essential oil and
The molten liquid of matrix is placed in the water dropper tank of pill dripping machine, is instilled in condensing agent to shrink to shape and is arrived mosquito repellent sustained-release dropping pill to obtain the final product；
The condensing agent is selected from atoleine, methyl-silicone oil or edible vegetable oil.
Compared with prior art, sustained-release dropping pill provided by the present invention solve plants essential oil is volatile, slow release effect not
Uniformly, sustained release the problems such as duration is difficult to control and processing difficulties, can according to different use requirements with hobby self assemble dripping pill
Usage quantity and using sequence, thus control essential oil single active constituent sustained release amount and sustained release duration；Preparation method is simple,
The dripping pill resting period prepared is long；Mosquito repellent dripping pill can also adjust pellet sizes, nontoxic, green ring according to different needs
It protects, mosquito will not be enabled to develop drug resistance；Active constituent in essential oil will be slow release, and mosquito repellent dripping pill is easy to carry, using just
Victory can be used with a variety of mosquito repellent carrier combinations, and repelling effect is good, and is free from side effects.
Specific embodiment
Present invention is further described in detail with reference to embodiments.
Molecule rectifying is carried out to commercially available essential oil first.
Commercially available Herba Lysimachiae foenumgraeci essential oil, vanilla flavour concentrate and the refined jasmine oil of purchase are divided respectively in wiped film molecular distillation instrument
Sub- rectifying, the specific method is as follows:
It is 20-40 DEG C that feeding temperature, which is arranged, opens water circulation vavuum pump, slowly opens balanced valve, until bubble-free generates, is closed
Balanced valve and water-circulating pump are closed, it is on the rocks in cold-trap, oil-sealed rotary pump is opened, adjusts vacuum degree to 200-400Pa, the present embodiment
For 300Pa, degassing to bubble-free generation stops, then gradually adjusts vacuum degree to 5-25Pa, the present embodiment 15Pa, at 20-45 DEG C
Lower progress first time distillation, distillation speed 0.8-3mL/min, the present embodiment 1.5mL/min, knifing machine revolving speed 150-
350rpm, the present embodiment 250rpm, remove part lower-molecular substance by 5-15 DEG C of cooling temperature.
The steaming excess distilled for the first time is taken, feeder is added, setting feeding temperature is 55-95 DEG C, and the present embodiment is 70 DEG C,
It is on the rocks in cold-trap, balanced valve is closed, oil-sealed rotary pump is opened, until after vacuum degree reaches 10-40Pa, the present embodiment 25Pa,
Diffusion pump is opened, and gradually opens balanced valve and is de-gassed, vacuum degree is adjusted after bubble-free to 1-25Pa, the present embodiment is
15Pa starts second at being 120 DEG C in 90-150 DEG C of the present embodiment and distills, distillation speed 0.5-8mL/min, the present embodiment
For 4mL/min, knifing machine revolving speed 150-450rpm, the present embodiment 300rpm, vacuum degree 1-25Pa, the present embodiment is
15Pa, cooling temperature are 15-35 DEG C, remove part polymer substance, collect steaming excess.
Herba Lysimachiae foenumgraeci essential oil, vanilla flavour concentrate and the refined jasmine oil steaming excess collected respectively are spare.
In each embodiment mosquito repellent sustained-release dropping pill the preparation method is as follows:
(1) each component is weighed according to the ratio；
(2) in 50 DEG C~70 DEG C heating lemon eucalyptus quintessence oils, until melting completely；In the lemon eucalyptus quintessence oil of thawing
Herba Lysimachiae foenumgraeci essential oil, vanilla flavour concentrate, refined jasmine oil and synergist is added, stirs evenly；Obtain essential oil composition；
(3) matrix is heated to melting at 75 DEG C~105 DEG C, essential oil composition is added after being subsequently cooled to 65~70 DEG C,
Stir evenly and keep 65~70 DEG C of constant temperature；
(4) temperature control system for adjusting pill dripping machine, makes 65 DEG C~95 DEG C of temperature of water dropper；The temperature of condensing agent is 35
DEG C~-5 DEG C；Stably reach above-mentioned state respectively to the temperature of pill dripping machine water dropper and condensing agent, will containing compound plant essential oil and
The molten liquid of matrix is placed in the water dropper tank of pill dripping machine, is instilled in condensing agent to shrink to shape and is arrived mosquito repellent sustained-release dropping pill to obtain the final product.
Each Example formulations are as shown in table 1.
Table 1
Each component unit is parts by weight in table 1, and temperature unit is DEG C；Herba Lysimachiae foenumgraeci essential oil, vanilla flavour concentrate and jasmine in table 1
Essential oil is molecular distillation treated steaming excess.
The sustained-release dropping pill application method being prepared is as follows:
(1) dripping pill is integrated on mosquito expelling plaster and mosquito-dispelling tablet by the modes such as embedding, inlaying, when use according to individual demand and
Hobby, effective component release the effects of by squeezing, rubbing in control dripping pill, plays mosquito-repelling function；
(2) dripping pill can be fitted into the devices such as sachet, bracelet, air purifier, be controlled by the effects of extruding, friction, melting
Effective component release in dripping pill processed, the effects of playing mosquito repellent, purify air, mind at rest；
(3) according to individual demand and hobby, the modes such as appropriate dripping pill friction or extruding are taken to stave dripping pill, in dripping pill
The mosquito-repellent essential oil compound of package can be directly applied on skin or clothing, play mosquito repellent, antipruritic, aromatic health effect；
(4) it takes appropriate dripping pill to be fitted into carry in the spray bottle equipped with liquid, concussion is rocked, and dripping pill is melted, and is made
Mosquito-expelling and antipruritic is spraying, is sprayed on skin or clothing, play mosquito repellent, it is antipruritic the effects of.
Claims (8)
1. a kind of mosquito repellent sustained-release dropping pill, it is characterised in that including essential oil composition and matrix；The essential oil composition and the base
The weight ratio of matter is 1:1 ~ 1:8；The essential oil composition includes following weight composition:
15 ~ 60 parts of lemon eucalyptus quintessence oil
5 ~ 30 parts of Herba Lysimachiae foenumgraeci essential oil
5 ~ 20 parts of vanilla flavour concentrate
5 ~ 30 parts of refined jasmine oil；
3 ~ 20 parts of synergist；
The synergist be selected from soybean oil, olive oil, sesame oil, coconut oil, bisabolol, salicylic acid, vanillic aldehyde, cinnamic acid and
At least one of gaultherolin；The matrix is selected from polyethylene glycol, sodium carboxymethyl starch, beta-cyclodextrin and polysorbate-
At least one of 80；
The mosquito repellent sustained-release dropping pill the preparation method is as follows:
(1) each component is weighed according to the ratio；
(2) in 50 DEG C ~ 70 DEG C heating lemon eucalyptus quintessence oils, until melting completely；It is added in the lemon eucalyptus quintessence oil of thawing
Herba Lysimachiae foenumgraeci essential oil, vanilla flavour concentrate, refined jasmine oil and the synergist, stir evenly；Obtain essential oil composition；
(3) matrix is heated to melting at 75 DEG C ~ 105 DEG C, the essential oil combination is added after being subsequently cooled to 65 ~ 70 DEG C
Object stirs evenly and keeps 65 ~ 70 DEG C of constant temperature；
(4) temperature control system for adjusting pill dripping machine, makes 65 DEG C ~ 95 DEG C of temperature of water dropper；The temperature of condensing agent be 35 DEG C ~-
5℃；Stably reach above-mentioned state respectively to the temperature of pill dripping machine water dropper and condensing agent, it will be containing compound plant essential oil and matrix
Molten liquid is placed in the water dropper tank of pill dripping machine, is instilled in condensing agent to shrink to shape and is arrived mosquito repellent sustained-release dropping pill to obtain the final product；
The condensing agent is selected from atoleine, methyl-silicone oil or edible vegetable oil.
2. mosquito repellent sustained-release dropping pill according to claim 1, it is characterised in that the composition of the essential oil composition are as follows:
20 ~ 50 parts of lemon eucalyptus quintessence oil
10 ~ 20 parts of Herba Lysimachiae foenumgraeci essential oil
10 ~ 15 parts of vanilla flavour concentrate
10 ~ 15 parts of refined jasmine oil
3 ~ 5 parts of soybean oil
2 ~ 4 parts of olive oil
3 ~ 5 parts of vanillic aldehyde.
3. mosquito repellent sustained-release dropping pill according to claim 1, it is characterised in that the composition of the essential oil composition are as follows:
25 parts of lemon eucalyptus quintessence oil
20 parts of Herba Lysimachiae foenumgraeci essential oil
10 parts of vanilla flavour concentrate
10 parts of refined jasmine oil
5 parts of gaultherolin
5 parts of cinnamic acid
5 parts of vanillic aldehyde.
4. according to claim 1 to mosquito repellent sustained-release dropping pill described in 3 any claims, it is characterised in that: the essential oil combination
The proportion of object and the matrix is 1:2 ~ 1:5.
5. mosquito repellent sustained-release dropping pill according to claim 4, it is characterised in that the matrix is Macrogol 4000, poly- second two
The mixture of alcohol 6000 and PEG 20000, the mass ratio of three are 1:1:1.
6. mosquito repellent sustained-release dropping pill according to claim 4, it is characterised in that the matrix is Macrogol 4000, poly- second two
The mixture of alcohol 12000 and sodium carboxymethyl starch, the mass ratio of three are 2:1:1.
7. mosquito repellent sustained-release dropping pill according to claim 4, it is characterised in that the matrix is polyethylene glycol 12000, poly- second
The mixture of glycol 8000, sodium carboxymethyl starch and beta-cyclodextrin, the polyethylene glycol 12000, PEG 8000, carboxymethyl
Sodium starch and beta-cyclodextrin mass ratio are 1:1:0.2:0.2.
8. the preparation method of mosquito repellent sustained-release dropping pill according to claim 1, it is characterised in that the Herba Lysimachiae foenumgraeci essential oil, vanilla
Oil, refined jasmine oil are first carrying out molecule rectifying using preceding respectively, and molecule rectificating method is as follows:
5-25Pa, vapo(u)rizing temperature be 20-45 DEG C, it is distillation speed 0.8-3mL/min, knifing machine revolving speed 150-350rpm, cold
But first time molecular distillation is carried out at 5-15 DEG C of temperature；
The steaming excess for taking first time molecular distillation in 1-25Pa, 90-150 DEG C of vapo(u)rizing temperature, distillation speed 0.5-8mL/min, is scraped
Film machine revolving speed 150-450rpm, at 15-35 DEG C of cooling temperature, second of molecular distillation is carried out, obtained steaming excess is as mosquito repellent
Essential oil raw material in sustained-release dropping pill.
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| CN111758723A (en) * | 2020-07-20 | 2020-10-13 | 成都彩虹电器（集团）股份有限公司 | Synergist for electric heating mosquito-repellent incense tablet and electric heating mosquito-repellent incense tablet |
| CN113412842A (en) * | 2021-06-23 | 2021-09-21 | 长江大学 | Mosquito repellent agent for pigsty and preparation method thereof |
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| CN1368272A (en) * | 2001-02-06 | 2002-09-11 | 杨孟君 | Nano medicine 'Zhengjin' and its preparing process |
| CN1443563A (en) * | 2003-03-18 | 2003-09-24 | 彭少明 | Huoluo oil |
| CN1730087A (en) * | 2005-08-11 | 2006-02-08 | 北京正大绿洲医药科技有限公司 | Wind dispelling drop pill containing amomum fruit and process for preparing the same |
| CN102579288A (en) * | 2012-04-06 | 2012-07-18 | 厦门鼎嘉奇投资管理有限公司 | Natural plant essential oil composition capable of directly serving as mosquito repellent |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1368272A (en) * | 2001-02-06 | 2002-09-11 | 杨孟君 | Nano medicine 'Zhengjin' and its preparing process |
| CN1443563A (en) * | 2003-03-18 | 2003-09-24 | 彭少明 | Huoluo oil |
| CN1730087A (en) * | 2005-08-11 | 2006-02-08 | 北京正大绿洲医药科技有限公司 | Wind dispelling drop pill containing amomum fruit and process for preparing the same |
| CN102579288A (en) * | 2012-04-06 | 2012-07-18 | 厦门鼎嘉奇投资管理有限公司 | Natural plant essential oil composition capable of directly serving as mosquito repellent |
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