CN105766901A - Mosquito-repelling sustained-release dropping pills and preparation method - Google Patents
Mosquito-repelling sustained-release dropping pills and preparation method Download PDFInfo
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- CN105766901A CN105766901A CN201610128201.9A CN201610128201A CN105766901A CN 105766901 A CN105766901 A CN 105766901A CN 201610128201 A CN201610128201 A CN 201610128201A CN 105766901 A CN105766901 A CN 105766901A
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- CN
- China
- Prior art keywords
- essential oil
- sustained
- anophelifuge
- oil
- release dropping
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000006187 pill Substances 0.000 title claims abstract description 52
- 238000013268 sustained release Methods 0.000 title claims abstract description 26
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000000341 volatile oil Substances 0.000 claims abstract description 34
- 239000003921 oil Substances 0.000 claims abstract description 33
- 239000000203 mixture Substances 0.000 claims abstract description 30
- 239000000758 substrate Substances 0.000 claims abstract description 21
- 235000010676 Ocimum basilicum Nutrition 0.000 claims abstract description 9
- 240000007926 Ocimum gratissimum Species 0.000 claims abstract description 9
- 235000019198 oils Nutrition 0.000 claims description 31
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- 235000018958 Gardenia augusta Nutrition 0.000 claims description 7
- 238000004821 distillation Methods 0.000 claims description 7
- 244000166124 Eucalyptus globulus Species 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 6
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 241000196324 Embryophyta Species 0.000 claims description 5
- 238000000199 molecular distillation Methods 0.000 claims description 5
- 229920002594 Polyethylene Glycol 8000 Polymers 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 4
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 4
- 238000010025 steaming Methods 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 230000008602 contraction Effects 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 238000007493 shaping process Methods 0.000 claims description 3
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 2
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims description 2
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 claims description 2
- 229920002538 Polyethylene Glycol 20000 Polymers 0.000 claims description 2
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 claims description 2
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims description 2
- 229940036350 bisabolol Drugs 0.000 claims description 2
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims description 2
- 229940117916 cinnamic aldehyde Drugs 0.000 claims description 2
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000008157 edible vegetable oil Substances 0.000 claims description 2
- 229940057995 liquid paraffin Drugs 0.000 claims description 2
- 229960001047 methyl salicylate Drugs 0.000 claims description 2
- 239000004006 olive oil Substances 0.000 claims description 2
- 235000008390 olive oil Nutrition 0.000 claims description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 2
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 229960004889 salicylic acid Drugs 0.000 claims description 2
- 229920002545 silicone oil Polymers 0.000 claims description 2
- 239000003549 soybean oil Substances 0.000 claims description 2
- 235000012424 soybean oil Nutrition 0.000 claims description 2
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims description 2
- 229940117960 vanillin Drugs 0.000 claims description 2
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 claims description 2
- 235000012141 vanillin Nutrition 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims 1
- 241000255925 Diptera Species 0.000 abstract description 6
- 238000005516 engineering process Methods 0.000 abstract description 2
- 230000001846 repelling effect Effects 0.000 abstract description 2
- 244000165852 Eucalyptus citriodora Species 0.000 abstract 2
- 235000004722 Eucalyptus citriodora Nutrition 0.000 abstract 2
- 235000010254 Jasminum officinale Nutrition 0.000 abstract 2
- 240000005385 Jasminum sambac Species 0.000 abstract 2
- 244000290333 Vanilla fragrans Species 0.000 abstract 2
- 235000009499 Vanilla fragrans Nutrition 0.000 abstract 2
- 235000012036 Vanilla tahitensis Nutrition 0.000 abstract 2
- 235000009508 confectionery Nutrition 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000012865 response to insecticide Effects 0.000 abstract 1
- 239000000077 insect repellent Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- 230000001139 anti-pruritic effect Effects 0.000 description 3
- 239000003908 antipruritic agent Substances 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000011505 plaster Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000011435 rock Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000010779 crude oil Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/18—Vapour or smoke emitting compositions with delayed or sustained release
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
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- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
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- A—HUMAN NECESSITIES
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- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
- A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
-
- A—HUMAN NECESSITIES
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
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- A61L9/012—Deodorant compositions characterised by being in a special form, e.g. gels, emulsions
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- A—HUMAN NECESSITIES
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- A61L9/00—Disinfection, sterilisation or deodorisation of air
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
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- Dentistry (AREA)
- Wood Science & Technology (AREA)
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- Environmental Sciences (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Dispersion Chemistry (AREA)
- Pest Control & Pesticides (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Birds (AREA)
- Toxicology (AREA)
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- Cosmetics (AREA)
Abstract
The invention relates to mosquito-repelling sustained-release dropping pills and a preparation method.The mosquito-repelling sustained-release dropping pills are characterized by be prepared from an essential oil combination and a matrix, wherein the weight ratio of the essential oil combination to the substrate ranges from 1:1 to 1:8, and the essential oil combination is prepared from eucalyptus citriodora essential oil, basil sweet essential oil, vanilla oil, jasmine essential oil and synergist.The preparation method comprises the steps that the eucalyptus citriodora essential oil is melted, the basil sweet essential oil, the vanilla oil, the jasmine essential oil and the synergist are added, and the materials are stirred to be uniform; the mixture is added to the melted matrix and stirred to be uniform, and the constant temperature is maintained; the dropping pills are preparedin a pill dropping machine according to a specified technology.According to the mosquito-repelling sustained-release dropping pills and the preparation method, the usage quantity and order of use of the pills can be self-assembled according to different usage requirements and hobbies, and therefore single active ingredient slow-release quantity and slow-release duration of the essential oil are controlled, mosquitoes cannot produce insecticide resistance, the pills can be matched with multiple mosquito-repelling carriers for use, and the mosquito repelling effect is good.
Description
Technical field
The present invention relates to mosquito repellent product, refer specifically to a kind of anophelifuge sustained-release dropping pill and preparation method.
Background technology
Mosquito repellent product common on the market has mosquito-repellent perfume, mosquito-driving liquid, mosquito-dispelling cream, anophelifuge aerosol, mosquito-repellent liquid, anophelifuge breast, mosquito-dispelling tablet, mosquito expelling plaster, anophelifuge gel etc..Directly acting on the repellent product of skin and be likely to cause that human body is uncomfortable and the problem such as allergy, the slow release formulation such as mosquito-dispelling tablet, mosquito expelling plaster then exists that slow release duration is uncontrollable, be not easy to the problems such as quality control；And use chemosynthesis repellant for a long time, in a large number and unreasonably, create a series of problem, therefore in the urgent need to researching and developing health, environmental protection, safe and effective novel mosquito-repellent.
Natural plant essential oils has the advantages such as renewable, degradable, meets the requirement that people are safe and environment-friendly to mosquito-repellent.But owing to the composition of quintessence oil is more complicated, it is easy to volatilization, being subject to the impact of environmental factors, and crude oil is after smearing skin, generally there are the shortcomings such as greasy, scorching hot in use procedure, minority is likely to also can produce twinge, is not suitable for direct use.
Summary of the invention
The technical problem to be solved is that the present situation for prior art provides a kind of slow release amount and the controlled anophelifuge sustained-release dropping pill of slow release duration.
Another technical problem to be solved by this invention is to provide a kind of slow release amount and the preparation method of the controlled anophelifuge sustained-release dropping pill of slow release duration.
This invention address that the technical scheme that above-mentioned technical problem adopts is: this anophelifuge sustained-release dropping pill, it is characterised in that include essential oil composition and substrate；The weight ratio of described essential oil composition and described substrate is 1:1～1:8；Described essential oil composition includes following weight composition:
Described synergist at least one in soybean oil, olive oil, Oleum sesami, Oleum Cocois, bisabolol, salicylic acid, vanillin, cinnamic aldehyde and methyl salicylate；Described substrate at least one in Polyethylene Glycol, carboxymethyl starch sodium, beta-schardinger dextrin-and Tween-80.
Preferably, the consisting of of described essential oil composition:
Better, the consisting of of described essential oil composition:
In above-mentioned each scheme, it is preferable that the proportioning of described essential oil composition and described substrate is 1:2～1:5.
Described substrate is preferably the mixture of Macrogol 4000, polyethylene glycol 6000 and PEG 20000, and the mass ratio of three is 1:1:1.
Or, described substrate is preferably the mixture of Macrogol 4000, Polyethylene Glycol 12000 and carboxymethyl starch sodium, and the mass ratio of three is 2:1:1.
Or, described substrate is preferably the mixture of Polyethylene Glycol 12000, PEG 8000, carboxymethyl starch sodium and beta-schardinger dextrin-, and described Polyethylene Glycol 12000, PEG 8000, beta-schardinger dextrin-mass ratio are 1:1:0.2:0.2.
The preparation method of anophelifuge sustained-release dropping pill in above-mentioned each scheme, it is characterised in that comprise the steps:
(1) each component is weighed by proportioning；
(2) Fructus Citri Limoniae eucalyptus quintessence oil is heated at 50 DEG C～70 DEG C, to melting completely；The Fructus Citri Limoniae eucalyptus quintessence oil melted adds sweet basil quintessence oil, Rhizoma et radix valerianae oil, jasmin quintessence oil and described synergist, stirs；Obtain essential oil composition；
(3) by described substrate 75 DEG C～105 DEG C heating to melted, add described essential oil composition after being subsequently cooled to 65～70 DEG C, stir and keep the constant temperature of 65～70 DEG C；
(4) adjusting the temperature control system of pill dripping machine, the temperature making water dropper is 65 DEG C～95 DEG C；The temperature of condensing agent is 35 DEG C～-5 DEG C；Treat that the temperature of pill dripping machine water dropper and condensing agent stably reaches above-mentioned state respectively, the fused solution containing compound plant essential oil and substrate is placed in the water dropper tank of pill dripping machine, instill contraction shaping in condensing agent and namely obtain anophelifuge sustained-release dropping pill；
Described condensing agent is selected from liquid paraffin, methyl-silicone oil or edible vegetable oil.
Compared with prior art, sustained-release dropping pill provided by the present invention solves that plants essential oil is volatile, slow release effect is uneven, slow release duration difficulty controls and the problem such as processing difficulties, can according to different user demands and the hobby usage quantity of self assemble drop pill and use order, thus controlling single active component slow release amount and the slow release duration of quintessence oil；Preparation method is simple, and the drop pill resting period prepared is long；Anophelifuge drop pill also according to different needs, can regulate pellet sizes, nontoxic, and environmental protection will not make mosquito develop immunity to drugs；Active component meeting slow releasing in quintessence oil, and anophelifuge drop pill is easy to carry, easy to use, can use with multiple anophelifuge carrier combination, repelling effect is good, and is free from side effects.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail.
First commercially available quintessence oil is carried out molecule rectification.
In wiped film molecular distillation instrument, the commercially available sweet basil quintessence oil bought, Rhizoma et radix valerianae oil and jasmin quintessence oil being carried out molecule rectification respectively, concrete grammar is as follows:
Feeding temperature is set and is 20-40 DEG C, open water circulation vacuum pump, slowly open balanced valve, produce to bubble-free, close balanced valve and water-circulating pump, in cold-trap on the rocks, open oil-sealed rotary pump, regulate vacuum to 200-400Pa, the present embodiment is 300Pa, degassed produce only to bubble-free, regulate vacuum more gradually to 5-25Pa, the present embodiment is 15Pa, first time distillation is carried out at 20-45 DEG C, distillation speed is 0.8-3mL/min, the present embodiment is 1.5mL/min, knifing machine rotating speed 150-350rpm, the present embodiment is 250rpm, chilling temperature 5-15 DEG C, remove part lower-molecular substance.
nullTake the steaming excess of first time distillation，Add feeder，Feeding temperature is set and is 55-95 DEG C，The present embodiment is 70 DEG C，In cold-trap on the rocks，Close balanced valve，Open oil-sealed rotary pump，After reaching 10-40Pa to vacuum，The present embodiment is 25Pa，Open diffusion pump，And unlatching balanced valve carries out degassed gradually，Vacuum is regulated to 1-25Pa after bubble-free，The present embodiment is 15Pa，It is at 120 DEG C, start second time distillation at 90-150 DEG C of the present embodiment，Distillation speed is 0.5-8mL/min，The present embodiment is 4mL/min，Knifing machine rotating speed 150-450rpm，The present embodiment is 300rpm，Vacuum is 1-25Pa，The present embodiment is 15Pa，Chilling temperature is 15-35 DEG C，Elimination part polymer substance，Collect and steam excess.
Collect the sweet basil quintessence oil, Rhizoma et radix valerianae oil and the jasmin quintessence oil steaming excess that obtain respectively standby.
In each embodiment, the preparation method of anophelifuge sustained-release dropping pill is as follows:
(1) each component is weighed by proportioning；
(2) Fructus Citri Limoniae eucalyptus quintessence oil is heated at 50 DEG C～70 DEG C, to melting completely；The Fructus Citri Limoniae eucalyptus quintessence oil melted adds sweet basil quintessence oil, Rhizoma et radix valerianae oil, jasmin quintessence oil and synergist, stirs；Obtain essential oil composition；
(3) by substrate 75 DEG C～105 DEG C heating to melted, add essential oil composition after being subsequently cooled to 65～70 DEG C, stir and keep the constant temperature of 65～70 DEG C；
(4) adjusting the temperature control system of pill dripping machine, the temperature making water dropper is 65 DEG C～95 DEG C；The temperature of condensing agent is 35 DEG C～-5 DEG C；Treat that the temperature of pill dripping machine water dropper and condensing agent stably reaches above-mentioned state respectively, the fused solution containing compound plant essential oil and substrate is placed in the water dropper tank of pill dripping machine, instill contraction shaping in condensing agent and namely obtain anophelifuge sustained-release dropping pill.
Each Example formulations is as shown in table 1.
Table 1
In table 1, each component unit is weight portion, and temperature unit is DEG C；Basil Essential in table 1, Rhizoma et radix valerianae oil and jasmin quintessence oil are the steaming excess after molecular distillation processes.
The sustained-release dropping pill using method prepared is as follows:
(1) drop pill is attached on mosquito expelling plaster and mosquito-dispelling tablet by modes such as embedding, inlay, according to individual demand and hobby during use, controls the effective ingredient release in drop pill through effects such as extruding, frictions, plays mosquito-repelling function；
(2) drop pill can load in the devices such as sachet, bracelet, air purifier, controls the effective ingredient in drop pill through effects such as extruding, rub, melt and discharges, and play anophelifuge, purification air, mind at rest etc. acts on；
(3) according to individual demand and hobby, drop pill is staved by the modes such as the friction of appropriate drop pill or extruding that take, and in drop pill, the mosquito-repellent essential oil complex of parcel can directly spread upon on skin or medicated clothing, plays anophelifuge, antipruritic, aromatic health effect；
(4) taking appropriate drop pill to load and carry with equipped with in the spray bottle of liquid, concussion is rocked, and makes drop pill melt, and makes mosquito-expelling and antipruritic spraying, is sprayed on skin or medicated clothing, plays anophelifuge, the effect such as antipruritic.
Claims (9)
1. an anophelifuge sustained-release dropping pill, it is characterised in that include essential oil composition and substrate；The weight ratio of described essential oil composition and described substrate is 1:1～1:8；Described essential oil composition includes following weight composition:
Described synergist at least one in soybean oil, olive oil, Oleum sesami, Oleum Cocois, bisabolol, salicylic acid, vanillin, cinnamic aldehyde and methyl salicylate；Described substrate at least one in Polyethylene Glycol, carboxymethyl starch sodium, beta-schardinger dextrin-and Tween-80.
2. anophelifuge sustained-release dropping pill according to claim 1, it is characterised in that consisting of of described essential oil composition:
3. anophelifuge sustained-release dropping pill according to claim 1, it is characterised in that consisting of of described essential oil composition:
4. the anophelifuge sustained-release dropping pill according to claims 1 to 3 any claim, it is characterised in that: the proportioning of described essential oil composition and described substrate is 1:2～1:5.
5. anophelifuge sustained-release dropping pill according to claim 4, it is characterised in that described substrate is the mixture of Macrogol 4000, polyethylene glycol 6000 and PEG 20000, the mass ratio of three is 1:1:1.
6. anophelifuge sustained-release dropping pill according to claim 4, it is characterised in that described substrate is the mixture of Macrogol 4000, Polyethylene Glycol 12000 and carboxymethyl starch sodium, and the mass ratio of three is 2:1:1.
7. anophelifuge sustained-release dropping pill according to claim 4, it is characterized in that the mixture that described substrate is Polyethylene Glycol 12000, PEG 8000, carboxymethyl starch sodium and beta-schardinger dextrin-, described Polyethylene Glycol 12000, PEG 8000, beta-schardinger dextrin-mass ratio are 1:1:0.2:0.2.
8. the preparation method of the anophelifuge sustained-release dropping pill as described in claim 1 to 7, it is characterised in that comprise the steps:
(1) each component is weighed by proportioning；
(2) Fructus Citri Limoniae eucalyptus quintessence oil is heated at 50 DEG C～70 DEG C, to melting completely；The Fructus Citri Limoniae eucalyptus quintessence oil melted adds sweet basil quintessence oil, Rhizoma et radix valerianae oil, jasmin quintessence oil and described synergist, stirs；Obtain essential oil composition；
(3) by described substrate 75 DEG C～105 DEG C heating to melted, add described essential oil composition after being subsequently cooled to 65～70 DEG C, stir and keep the constant temperature of 65～70 DEG C；
(4) adjusting the temperature control system of pill dripping machine, the temperature making water dropper is 65 DEG C～95 DEG C；The temperature of condensing agent is 35 DEG C～-5 DEG C；Treat that the temperature of pill dripping machine water dropper and condensing agent stably reaches above-mentioned state respectively, the fused solution containing compound plant essential oil and substrate is placed in the water dropper tank of pill dripping machine, instill contraction shaping in condensing agent and namely obtain anophelifuge sustained-release dropping pill；
Described condensing agent is selected from liquid paraffin, methyl-silicone oil or edible vegetable oil.
9. the preparation method of anophelifuge sustained-release dropping pill according to claim 8, it is characterised in that described sweet basil quintessence oil, Rhizoma et radix valerianae oil, jasmin quintessence oil first carry out molecule rectification before use respectively, and molecule rectificating method is as follows:
5-25Pa, vapo(u)rizing temperature be 20-45 DEG C, distillation speed be at 0.8-3mL/min, knifing machine rotating speed 150-350rpm, chilling temperature 5-15 DEG C, carry out first time molecular distillation；
Take the steaming excess of first time molecular distillation, 1-25Pa, vapo(u)rizing temperature 90-150 DEG C, distillation speed 0.5-8mL/min, knifing machine rotating speed 150-450rpm, at chilling temperature 15-35 DEG C, carrying out second time molecular distillation, what obtain steams excess as the quintessence oil raw material in anophelifuge sustained-release dropping pill.
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| CN111758723A (en) * | 2020-07-20 | 2020-10-13 | 成都彩虹电器（集团）股份有限公司 | Synergist for electric heating mosquito-repellent incense tablet and electric heating mosquito-repellent incense tablet |
| CN113412842A (en) * | 2021-06-23 | 2021-09-21 | 长江大学 | Mosquito repellent agent for pigsty and preparation method thereof |
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| CN105766901B (en) | 2019-06-18 |
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