CN105641260A - Traditional Chinese medicinal composition for treating piglet edema disease and preparation method of traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition for treating piglet edema disease and preparation method of traditional Chinese medicinal composition Download PDFInfo
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- CN105641260A CN105641260A CN201410628995.6A CN201410628995A CN105641260A CN 105641260 A CN105641260 A CN 105641260A CN 201410628995 A CN201410628995 A CN 201410628995A CN 105641260 A CN105641260 A CN 105641260A
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Abstract
The invention relates to a traditional Chinese medicinal composition for treating the piglet edema disease and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition is prepared from the following medicinal materials in parts by weight: 1-10 parts of white atractylodes rhizome, 1-10 parts of mirabilite, 1-5 parts of rhizoma coptidis, 1-5 parts of cortex phellodendri, 1-10 parts of rhizoma alismatis, 1-10 parts of poria cocos, 1-5 parts of fructus aurantii, 1-5 parts of medicated leaven, 1-5 parts of herba commelinae, 1-10 parts of herba plantaginis, and 1-5 parts of licorice root. The traditional Chinese medicinal composition has the efficacies of clearing away heat and toxic materials, as well as relieving sore-throat and wetting the laryngopharynx, is simple in preparation method, convenient to use, low in price, small in toxic and side effects, and free of drug residue, and belongs to a good traditional Chinese medicinal composition for treating the piglet edema disease.
Description
Technical field
The invention belongs to field of veterinary, especially a kind of Chinese medicine composition and its preparation method treating baby pig edema.
Background technology
Baby pig edema is the infectivity enterotoxin mass formed by blood stasis that a kind of pathogenic colon bacillus being colonizated in small intestine by certain causes. On clinical, nervous symptoms hoarse taking acute death, eyelid swelled, cry and greater gastric curvature and mesocolon oedema are as feature. This disease is how popular in region, all can occur throughout the year, and Xia Qiu is multiple; and wean after 1��2 week and those eat many, grow piglets fast, that height is big the most common; if do not given treatment to early, mortality ratio almost 100%, seriously affect large-scale pig farm piglet and cultivates the sound development with pig industry.
Baby pig edema is clinical mainly shows as ataxia, and four limbs are disorderly dynamic, shape of seemingly swimming, the sick common face of pig, palpebral edema, and severe one is extended down to face, neck, and head becomes fat. Major lesions is oedema. Owing to the cause of disease is extremely complicated, but the measure treating this disease is little, usually adopts immunoprophylaxis, eliminates the prevention and controls such as the cause of disease, comprehensive symptomatic treatment, i.e. antisepsis and anti-inflammation, Qiang Xin, removing toxic substances, diuresis. Although this disease of prevention and corntrol is had certain effect by these methods, but then effect is very micro-to the heavier chicken of morbidity. Therefore, in clinical treatment, we adopt and eliminate the cause of disease in conjunction with Chinese medicine composition spice administration of the present invention, obtain better effects.
Chinese medicine is the pure natural substance that animal body the most easily absorbs, containing multiple biological effective components, toxic side effect is very micro-, almost noresidue, without resistance, meat product, egg-products are had no side effect, free from environmental pollution so that Chinese medicine has unique advantage preventing and treating in the disease of domestic animals.
Summary of the invention
The present invention has effect clearing heat and detoxicating, profit pharynx profit larynx, and the Chinese medicinal preparation method of itself and the present invention is simple, easy to use, cheap, toxic side effect is little, drug residue free, is the Chinese medicine composition of a kind for the treatment of baby pig edema well.
Another object of the present invention is to provide the preparation method of a kind of Chinese medicine composition treating baby pig edema.
The present invention is achieved by the following technical solutions:
Treating a Chinese medicine composition for baby pig edema, component and the ratio of weight and number thereof of its Chinese medicine composition are respectively:
Bighead atractylodes rhizome 1-10 part;
Saltcake 1-10 part;
Coptis 1-5 part;
Golden cypress 1-5 part;
Rhizoma alismatis 1-10 part;
Poria cocos 1-10 part;
Fructus Aurantii 1-5 part;
Divine Comedy 1-5 part;
Duck opens up grass 1-5 part;
Psyllium 1-10 part;
Radix Glycyrrhizae 1-5 part.
Treating a preparation method for the Chinese medicine composition of baby pig edema, the step of its preparation method is as follows:
(1) take the bighead atractylodes rhizome respectively according to weight proportion, saltcake, the coptis, golden cypress, rhizoma alismatis, Poria cocos, Fructus Aurantii, Divine Comedy, duck opened up grass, psyllium and Radix Glycyrrhizae and pulverize, and all sieved by 80 orders respectively;
(2) bighead atractylodes rhizome after sieving in step (1), saltcake, the coptis, golden cypress, rhizoma alismatis, Poria cocos, Fructus Aurantii, Divine Comedy, duck are opened up grass, psyllium and Radix Glycyrrhizae and put in mixing tank, fully mix, namely obtain treating the Chinese medicine composition finished product of baby pig edema.
Advantage and the useful effect of the present invention be:
1, the bighead atractylodes rhizome that contains in the Chinese medicine composition of this treatment baby pig edema, saltcake, the coptis, golden cypress, rhizoma alismatis, Poria cocos, Fructus Aurantii, Divine Comedy, duck open up the Chinese medicinal ingredients such as grass, psyllium, Radix Glycyrrhizae, and the baby pig edema multiple factor caused has good preventive and therapeutic effect.
2, the Chinese medicine composition of the present invention is to quite stable in stomach-tissue environment, absorbs good, and be not subject to the impact of temperature, potential of hydrogen, the Plasma Concentration required for reaching treatment in the short period of time after for oral administration.
3, the present invention has effect clearing heat and detoxicating, profit pharynx profit larynx, and the Chinese medicinal preparation method of itself and the present invention is simple, easy to use, cheap, toxic side effect is little, drug residue free, is the Chinese medicine composition of a kind for the treatment of baby pig edema well.
Embodiment
The present invention is described in further detail by following examples. It should be understood that following embodiment is explanation property, it not limited, protection scope of the present invention can not be limited with following embodiment.
The bighead atractylodes rhizome involved in the present invention, saltcake, the coptis, golden cypress, rhizoma alismatis, Poria cocos, Fructus Aurantii, Divine Comedy, duck are opened up grass, psyllium and Radix Glycyrrhizae and all can commercially be bought and obtain.
Embodiment 1
Treating a Chinese medicine composition for baby pig edema, component and the weight thereof of its Chinese medicine composition are respectively:
Bighead atractylodes rhizome 10g, saltcake 10g, coptis 10g, golden cypress 10g, rhizoma alismatis 10g, Poria cocos 10g, Fructus Aurantii 10g, Divine Comedy 10g, duck open up grass 10g, psyllium 10g, Radix Glycyrrhizae 10g.
Treating a preparation method for the Chinese medicine composition of baby pig edema, the step of preparation technology is as follows:
(1) take the bighead atractylodes rhizome respectively according to weight proportion, saltcake, the coptis, golden cypress, rhizoma alismatis, Poria cocos, Fructus Aurantii, Divine Comedy, duck opened up grass, psyllium and Radix Glycyrrhizae and pulverize, and all sieved by 80 orders respectively;
(2) bighead atractylodes rhizome after sieving in step (1), saltcake, the coptis, golden cypress, rhizoma alismatis, Poria cocos, Fructus Aurantii, Divine Comedy, duck are opened up grass, psyllium and Radix Glycyrrhizae and put in mixing tank, fully mix, namely obtain treating the Chinese medicine composition finished product of baby pig edema.
Embodiment 2
Treating a Chinese medicine composition for baby pig edema, component and the weight thereof of its Chinese medicine composition are respectively:
Bighead atractylodes rhizome 100g, saltcake 100g, coptis 50g, golden cypress 50g, rhizoma alismatis 100g, Poria cocos 100g, Fructus Aurantii 50g, Divine Comedy 50g, duck open up grass 50g, psyllium 100g, Radix Glycyrrhizae 50g.
The step of its preparation method is with embodiment 1.
Embodiment 3
Treating a Chinese medicine composition for baby pig edema, component and the weight thereof of its Chinese medicine composition are respectively:
Bighead atractylodes rhizome 50g, saltcake 50g, coptis 25g, golden cypress 25g, rhizoma alismatis 50g, Poria cocos 50g, Fructus Aurantii 25g, Divine Comedy 40g, duck open up grass 40g, psyllium 50g, Radix Glycyrrhizae 40g.
The step of its preparation method is with embodiment 1.
Clinical application
In order to verify that the present invention is to the clinical therapeutic efficacy of baby pig edema, the case of pig natural infection baby pig edema has been carried out efficacy experiment with the present invention by us. The present invention is divided into basic, normal, high three dosage that animal carries out grouping administration by test, compares with the infection control group of baby pig edema, thus evaluates result for the treatment of and the optimum amount of the present invention.
1 materials and methods
1.1 experimental animal
There is provided by pig farm, Tianjin. Inspection is cutd open and Tianjin livestock and poultry inspection center takes disease chitterlings and mucous membrane of colon mucus pathological material of disease to carry out bacteriology checking and be use O through clinical observation, pathology138��O139��O141Do glass plate aggegation qualification O antigen Deng intestinal bacteria antiserum(antisera) and bacterial suspension and make glass plate aggegation qualification pili antigen with bacterium and F18 pili monoclonal antibody, make a definite diagnosis the piglet 24 for suffering from baby pig edema and use pig as test.
1.2 trial drug
The present invention is prepared by our company.
Injection of Norfloxacin: produce by Shanxi Ya Bao veterinary drug company limited, product batch number 121113, specification 5mL: Norxin 0.11g.
1.3 test method
The case of baby pig edema is primarily of clinical symptom, and the methods such as inspection change and Virus Isolation of cuing open are made a definite diagnosis, and then disease pig random packet are treated by test personnel.
The Case definition of 1.4 baby pig edema
Clinical symptom:
Sick pig sudden onset, body temperature is not high, quadruped locomotion obstacle, and rear body is unable, waves and ataxia; The sick pig having does circular motion or blindly disorderly punching, violent body wash-ahead suddenly; When various stimulation or seizure, the scream touched, calls hoarse, falls down to the ground, and four limbs are disorderly dynamic, shape of seemingly swimming; The sick common face of pig, palpebral edema, severe one is extended down to face, neck, and head becomes fat.
Cut open inspection change:
Major lesions is oedema. Upper lower eyelid, face, lower jaw part, overhead are subcutaneous in canescence bean jelly sample oedema. Curved greatly, the cardiac region oedema of stomach, in gel-shaped oedema between the mucous layer and muscle layer of stomach; Film and lymphoglandula oedema thereof between colon intestines, film bean jelly sample between whole intestines, cuts and has volume liquid to flow out, and intestinal mucosa is red and swollen, even hemorrhage.
Virus Isolation:
Disease chitterlings and mucous membrane of colon mucus pathological material of disease is taked to carry out bacteriology checking and be use O138��O139��O141Do glass plate aggegation qualification O antigen Deng intestinal bacteria antiserum(antisera) and bacterial suspension and make glass plate aggegation qualification pili antigen with bacterium and F18 pili monoclonal antibody, make a definite diagnosis.
1.5 experimental animal groupings and process
The sick pig of the baby pig edema of naturally-occurring is divided into 5 groups at random, often organizes 12.
Test 1 group for infecting control group, do not process.
Testing 2 groups is low dose group of the present invention, 1/2 times amount (the per kilogram body weight 1g) administration of clinical recommended dose, spice, successive administration 5 days.
Testing 3 groups is dosage group in the present invention, clinical recommended dose (per kilogram body weight 2g) administration, spice, successive administration 5 days.
Testing 4 groups is high dose group of the present invention, 2 times amount (the per kilogram body weight 4g) administration of clinical recommended dose, spice, successive administration 5 days.
Testing 5 groups is Injection of Norfloxacin group, uses according to specification sheets: every day twice, intramuscular injection, the amount administration of per kilogram body weight 5mL, successive administration 5 days.
1.6 result for the treatment of decision methods
Curative ratio:
Medication postoperative infection pig clinical symptom disappearance, body temperature, spirit, nervous symptoms etc. are all same as normal pig, and oedema situation disappears, and are all judged as curing. The ratio calculating curative ratio that this group tests head number is accounted for according to curing head number.
Inefficiency:
Medication postoperative infection pig, the clinical symptom such as body temperature, spirit, appetite, nervous symptoms still lose the even deterioration death person that takes a turn for the better, and it is invalid to be all judged as.The ratio accounting for this group test head number according to invalid head number calculates inefficiency.
1.7 statistical analysis
The percentage ratios such as result for the treatment of curative ratio, inefficiency represent. Comparison in difference between group adopts chi square test to analyze. P < 0.05 and P < 0.01 represents significant difference and extremely remarkable respectively.
2 test-results
To natural infection baby pig edema, after the spice administration of this Chinese medicine composition, by comparing with infection control group, the clinical symptom of morbidity pig obviously alleviates. The situation that the result for the treatment of of middle dosage group and laying rate significantly rise all reaches desirable requirement. The results are shown in Table 1.
Table 1 observation of curative effect
| Group | Sick pig's head number | Invalid head number | Inefficiency (%) | Cure head number | Curative ratio (%) |
| 1. infect control group | 12 | 12 | 100.0 | 0 | 0.0 |
| 2. low dose group of the present invention | 12 | 7 | 58.3 | 5 | 41.7 |
| 3. dosage group in the present invention | 12 | 0 | 0.0 | 12 | 100.0 |
| 4. high dose group of the present invention | 12 | 1 | 8.3 | 11 | 91.7 |
| 5. Injection of Norfloxacin group | 12 | 3 | 25.0 | 9 | 75.0 |
3 result analyses
Analyzing from clinical symptom, inefficiency, curative ratio three aspects, the result for the treatment of of middle dosage group is obviously higher than other treatment group. Through statistical analysis, case fatality rate and curative ratio significant difference (P > 0.01) between medication group, laying rate difference is very significantly (P > 0.05).
4 conclusions
The present invention presses per kilogram body weight 4g administration, spice, clinical type baby pig edema is had good therapeutic action in continuous 5 days.
Claims (2)
1. treat the Chinese medicine composition of baby pig edema for one kind, it is characterised in that: component and the ratio of weight and number thereof of this Chinese medicine composition are respectively:
2. treat the preparation method of the Chinese medicine composition of baby pig edema as claimed in claim 1 for one kind, it is characterised in that: the step of this preparation method is as follows:
(1) take the bighead atractylodes rhizome respectively according to weight proportion, saltcake, the coptis, golden cypress, rhizoma alismatis, Poria cocos, Fructus Aurantii, Divine Comedy, duck opened up grass, psyllium and Radix Glycyrrhizae and pulverize, and all sieved by 80 orders respectively;
(2) bighead atractylodes rhizome after sieving in step (1), saltcake, the coptis, golden cypress, rhizoma alismatis, Poria cocos, Fructus Aurantii, Divine Comedy, duck are opened up grass, psyllium and Radix Glycyrrhizae and put in mixing tank, fully mix, namely obtain treating the Chinese medicine composition finished product of baby pig edema.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105963443A (en) * | 2016-07-14 | 2016-09-28 | 成都中牧生物药业有限公司 | Composition for treating piglet edema |
| CN107536922A (en) * | 2017-10-23 | 2018-01-05 | 天津瑞贝特科技发展有限公司 | Treat Chinese medicine composition of bowel oedema disease and preparation method thereof |
| CN107648398A (en) * | 2017-11-03 | 2018-02-02 | 天津瑞贝特科技发展有限公司 | Treat the Chinese medicine composition of escherichia coli of piglets type stomach and intestine oedema |
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| CN101244164A (en) * | 2007-02-13 | 2008-08-20 | 梁永养 | Medicament for preventing and treating hydropsy of pigling |
| CN102784306A (en) * | 2012-08-31 | 2012-11-21 | 山东新希望六和集团有限公司 | Traditional Chinese medicine composition and feed for treating piglet edema disease and preparation methods of traditional Chinese medicine composition and feed |
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2014
- 2014-11-11 CN CN201410628995.6A patent/CN105641260A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244164A (en) * | 2007-02-13 | 2008-08-20 | 梁永养 | Medicament for preventing and treating hydropsy of pigling |
| CN102784306A (en) * | 2012-08-31 | 2012-11-21 | 山东新希望六和集团有限公司 | Traditional Chinese medicine composition and feed for treating piglet edema disease and preparation methods of traditional Chinese medicine composition and feed |
Non-Patent Citations (1)
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| 王自力: "《生态养猪》", 31 August 2011, 中国农业出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105963443A (en) * | 2016-07-14 | 2016-09-28 | 成都中牧生物药业有限公司 | Composition for treating piglet edema |
| CN107536922A (en) * | 2017-10-23 | 2018-01-05 | 天津瑞贝特科技发展有限公司 | Treat Chinese medicine composition of bowel oedema disease and preparation method thereof |
| CN107648398A (en) * | 2017-11-03 | 2018-02-02 | 天津瑞贝特科技发展有限公司 | Treat the Chinese medicine composition of escherichia coli of piglets type stomach and intestine oedema |
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Application publication date: 20160608 |