CN105585539A - 一锅法合成头孢他啶侧链酸乙酯的方法 - Google Patents
一锅法合成头孢他啶侧链酸乙酯的方法 Download PDFInfo
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- CN105585539A CN105585539A CN201510967718.2A CN201510967718A CN105585539A CN 105585539 A CN105585539 A CN 105585539A CN 201510967718 A CN201510967718 A CN 201510967718A CN 105585539 A CN105585539 A CN 105585539A
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- ethyl ester
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
- C07D277/593—Z being doubly bound oxygen or doubly bound nitrogen, which nitrogen is part of a possibly substituted oximino radical
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- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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CN201510967718.2A CN105585539B (zh) | 2015-12-21 | 2015-12-21 | 一锅法合成头孢他啶侧链酸乙酯的方法 |
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CN201510967718.2A CN105585539B (zh) | 2015-12-21 | 2015-12-21 | 一锅法合成头孢他啶侧链酸乙酯的方法 |
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CN105585539A true CN105585539A (zh) | 2016-05-18 |
CN105585539B CN105585539B (zh) | 2018-01-23 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108169399A (zh) * | 2017-12-15 | 2018-06-15 | 山东金城医药化工有限公司 | 去甲氨噻肟酸乙酯粗品中杂质的分离方法 |
CN110790721A (zh) * | 2019-12-06 | 2020-02-14 | 山东金城医药化工有限公司 | 头孢他啶侧链酸乙酯的合成方法 |
CN114031575A (zh) * | 2021-12-15 | 2022-02-11 | 山东金城医药化工有限公司 | 去甲氨噻肟酸乙酯的制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1709879A (zh) * | 2005-06-08 | 2005-12-21 | 浙江普洛化学有限公司 | 制备(z)-2-(2-氨基-4-噻唑)-2-羟基亚胺乙酸酯及其衍生物的方法 |
CN102617507A (zh) * | 2012-03-15 | 2012-08-01 | 苏州中联化学制药有限公司 | 一种头孢他啶侧链酸活性酯的制备方法 |
CN103232405A (zh) * | 2013-04-28 | 2013-08-07 | 山东优胜美特医药有限公司 | 一种新头孢侧链中间体的合成方法 |
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2015
- 2015-12-21 CN CN201510967718.2A patent/CN105585539B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1709879A (zh) * | 2005-06-08 | 2005-12-21 | 浙江普洛化学有限公司 | 制备(z)-2-(2-氨基-4-噻唑)-2-羟基亚胺乙酸酯及其衍生物的方法 |
CN102617507A (zh) * | 2012-03-15 | 2012-08-01 | 苏州中联化学制药有限公司 | 一种头孢他啶侧链酸活性酯的制备方法 |
CN103232405A (zh) * | 2013-04-28 | 2013-08-07 | 山东优胜美特医药有限公司 | 一种新头孢侧链中间体的合成方法 |
Non-Patent Citations (2)
Title |
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梁宝臣等: "头孢他啶侧链酸及其活性硫酯的合成研究", 《中国抗生素杂志》 * |
潘劲松等: "去甲基氨噻肟酸乙酯合成新工艺研究", 《山东化工》 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108169399A (zh) * | 2017-12-15 | 2018-06-15 | 山东金城医药化工有限公司 | 去甲氨噻肟酸乙酯粗品中杂质的分离方法 |
CN110790721A (zh) * | 2019-12-06 | 2020-02-14 | 山东金城医药化工有限公司 | 头孢他啶侧链酸乙酯的合成方法 |
CN110790721B (zh) * | 2019-12-06 | 2021-10-22 | 山东金城医药化工有限公司 | 头孢他啶侧链酸乙酯的合成方法 |
CN114031575A (zh) * | 2021-12-15 | 2022-02-11 | 山东金城医药化工有限公司 | 去甲氨噻肟酸乙酯的制备方法 |
CN114031575B (zh) * | 2021-12-15 | 2023-09-12 | 山东金城医药化工有限公司 | 去甲氨噻肟酸乙酯的制备方法 |
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Address after: 255129 Zichuan Economic Development Zone, Shandong, China, Zibo Applicant after: SHANDONG JINCHENG PHARMACEUTICAL GROUP CO.,LTD. Address before: 255129 Zichuan Economic Development Zone, Shandong, China, Zibo Applicant before: SHANDONG JINCHENG PHARMACEUTICAL CO.,LTD. Address after: 255129 Zichuan Economic Development Zone, Shandong, China, Zibo Applicant after: SHANDONG JINCHENG PHARMACEUTICAL CO.,LTD. Address before: 255129 Zichuan Economic Development Zone, Shandong, China, Zibo Applicant before: SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL Co.,Ltd. |
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Effective date of registration: 20171227 Address after: 255100, No. 288, Sheng Lu, Kunlun Town, Zichuan District, Shandong, Zibo Applicant after: SHANDONG JINCHENG MEDICINE CHEMICAL CO.,LTD. Address before: 255129 Zichuan Economic Development Zone, Shandong, China, Zibo Applicant before: SHANDONG JINCHENG PHARMACEUTICAL GROUP CO.,LTD. |
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