CN105581924B - A kind of compound cassia bark oil nanometer emulsion and preparation method thereof - Google Patents
A kind of compound cassia bark oil nanometer emulsion and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
Abstract
The invention belongs to cosmetic field, specially a kind of compound cassia bark oil nanometer emulsion and preparation method thereof.Compound cassia bark oil nanometer emulsion, is made of vegetable oil, organic materials, deionized water and auxiliary material, includes wherein cassia oil, samara oil, peppermint oil in vegetable oil, organic materials includes alkyl glycosides, 1,2-PD；Auxiliary material includes caprylic/capric triglyceride, SCY, vitamin E, Dermosoft Eco 1388 and citric acid.Compound cassia bark nano-emulsion of the present invention has significant anti-bite by mosquitos antipruritic and anti-inflammatory treatment effect, and material therefor is environmentally protective, and preparation method is easy, and preparation stabilization is suitable for realizing industrialized production.
Description
Technical field
The invention belongs to cosmetic field, specially a kind of compound cassia bark oil nanometer emulsion and preparation method thereof, the nano-emulsion
Main component is formed by extract cassia oil, samara oil, the mint oil combination of pure plant, can prevent bite by mosquitos, and skin
Skin is smeared after bite by mosquitos can play antipruritic antiinflammation.
Background technique
Bite by mosquitos usually causes the itch and swelling and pain of local skin, is easy to induce inflammation, i.e. insect bite dermatitis, Chang Yin is scratched
It grabs and the suppurative dermatosis such as secondary pustule sore.Currently, the traditional treatment of insect dermatitis mainly has: 1. is for oral administration, mainly benzene sea
Lamine, phenergan, chlorpheniramine, hormone, and use vitamin C or vitamin B12 and the combination therapy of antihistaminic medicine；Outside 2.
With disposing to the ill, such as selection floral water, essential wind oil is outer puts on the skin.And these traditional therapies, there is side effect is big, effect is not
Good disadvantage.
Summary of the invention
The object of the present invention is to provide a kind of mosquito controls to bite, the compound cassia bark oil nanometer emulsion of relieving itching and eliminating swelling obvious effect
And preparation method thereof.The present invention selects the surfactant of nontoxic green by the screening reasonable formula to pure plant oil
And cosurfactant, the ratio of emulsion each component is determined by pseudo-ternary phase diagram, and curative effect is verified by animal experiment, with system
The standby compound cassia bark oil nanometer emulsion that quality is stable, efficacy lasting, safety is good.
The present invention adopts the following technical scheme that realization: a kind of compound cassia bark oil nanometer emulsion, by vegetable oil, organic matter
Material, deionized water and auxiliary material are constituted, and wherein include the cassia bark configured according to weight part ratio for 1~6:1~4:2~5 in vegetable oil
Oil, samara oil, peppermint oil, it is 2.0%~8.0% that vegetable oil, which accounts for nano-emulsion weight percent, and organic materials includes according to weight
Part than be 4~6:1~2 configure alkyl glycosides, 1,2-PD, organic materials account for nano-emulsion weight percent be 30%~
40%；It is 35%~45% that deionized water, which accounts for nano-emulsion weight percent,；Auxiliary material includes caprylic/capric triglyceride, SCY, dimension
Raw element E, Dermosoft Eco 1388 and citric acid, caprylic/capric triglyceride account for nano-emulsion weight percent for 2.0%~
6.0%, SCY account for nano-emulsion weight percent be 0.5%~5.0%, vitamin E account for nano-emulsion weight percent be 0.05%~
It is 3.0%~5.0% that 0.2%, Dermosoft Eco 1388, which accounts for nanoemulsion weight ratio, and citric acid accounts for nano-emulsion weight percent
Than being 10%~20%.
The preparation method of above-mentioned compound cassia bark oil nanometer emulsion, comprising the following steps:
Step 1: cassia oil, samara oil, peppermint oil are weighed according to weight part ratio for 1~6:1~4:2~5, then mix
It closes, stir evenly, sequentially add caprylic/capric triglyceride and vitamin E, stir evenly, obtain A phase；By alkyl glycosides,
1,2-PD is that 4~6:1~2 weigh according to weight part ratio, then mixes, stirs evenly, obtains B phase；While stirring by A phase
It is added in B phase and stirs evenly, obtain A/B phase；It is made above can be at 20 DEG C~30 DEG C, revolving speed is 800rpm~1200rpm
Stirring condition under carry out；
Step 2: the SCY for weighing prescription amount is add to deionized water and stirs evenly, C phase is obtained, deionized water used
Amount is the 3/4 of deionized water full dose；C phase is delayed under 25 DEG C~35 DEG C, the stirring condition that revolving speed is 1500rpm~3000rpm
Slowly it is homogeneously added into above-mentioned A/B phase, then Dermosoft Eco 1388 is slowly added dropwise, continue 5~10min of stirring to system
As the clear and bright shape lotion of yellow, D phase is obtained；
It is dissolved in D phase step 3: weighing citric acid, finally plus pure remaining deionized water, stirs evenly, adjust the pH of D phase
To 5.0~6.0, compound cassia bark oil nanometer emulsion is obtained.
Pure natural plant extract cassia oil has an extensive pharmacological activity, especially in antibacterial anti-inflammatory, desinsection expelling parasite, anti-
Oxidation etc. has biggish utility value, and cassia oil all has a strong inhibitory effect common bacteria, saccharomycete, mould,
Fungistatic effect is still more obvious in gas phase diffusion bacteriostatic experiment；Cassia oil is a kind of effective free radical scavenger, to grease
Also there is preferable antioxidation, effect of the oxidation resistance than 0.05%Vc is good.Vitamin E in samara oil has anti-oxidant
Effect delays cell aging due to oxidation, promotes Dermal microvessel circulation, keeps skin elasticity, can prevent skin scar；
It is another to lock moisture, there is deep skin " moisturizer " good reputation；Even skin reduces skin antiinflammation.Peppermint oil has obvious stop
Itch, multiple actions, the especially test result such as antibacterial, antiviral and mosquito repellent show that human body is smeared peppermint oil and average can be driven at night
Except 85% all kinds of mosquitoes；The antibacterial action that peppermint oil has had, and have purifying skin, Bergamot Mint Extract, shrink capilary
Etc. curative effects, and transdermal effect is good, is now widely used for beauty industry.
Nano-emulsion is a kind of new form of administration, and quality is stablized, and strong permeability and is absorbed rapidly, and curative effect drop can be enhanced
Less toxic side effect has powerful advantage in transdermal drug delivery system.Plant extracts, especially essential oil high volatility, stability is low, function
Effect can be impacted.But after nano-emulsion system is coated with, has many advantages, such as high density, strong infiltration, easily absorbs, stability, separately
Outer nano-emulsion is prepared under conditions of 25 DEG C or so, does not influence its content and activity, fine droplet of the functional component in nano-emulsion
Interior concentration can achieve it is very high, and natural essential oil functional component quickly through surfactant molecule form interfacial film, in skin
Skin surface can quickly form functional component gradient penetration storage cavern, reach the characteristics of making natural essential oil efficiently act on and be sustained, and maintain
Effect is permanent.
The present invention is exactly to be acted on according to the effect of cassia oil, samara oil, peppermint oil, is made into nano-emulsion, playing prevents
Bite by mosquitos and pruitus caused by bite by mosquitos, redness, even inflammation and the effect of pain, are acted on.Due to volatile oil
Class drug is extremely difficult to be dissolved in water, and stability is poor, is easy to scatter and disappear, influences drug effect, after being made into O/W type nano-emulsion, can prevent medicine
Object volatilization, oxidation, improve stability, improve drug effect, reach sustained release or target administration purpose, develop a kind of pair of mosquito for market and sting
The novel form of the treatment and prevention more remarkable treatment effect of red swelling of the skin caused by stinging.
The innovative point of the invention patent is: 1. selection pure plant oil cassia oils, samara oil, peppermint oil prescription, both
Itching analgesic after playing the role of mosquito-proof sting and biting, and have no toxic and side effect to human body, is nonirritant.Cassia oil is in addition to preceding
The antibacterial action stated, there are also certain analgesic activities；Peppermint oil can not only drive away mosquito, but also can also effectively kill mosquito children
Worm, and have apparent refrigerant antipruritic and certain anti-inflammatory and analgesic effect；In addition the significant skin care effect of samara oil, three's compatibility effect
Fruit is splendid.
2. alkyl glycosides (APG) is the product that glucose and natural fatty alcohol generate, easily biological-degradable, nontoxic, non-stimulated,
It is pollution-free, it is " green " surfactant, surface property is good, and reduction surface tension is strong, and emulsibility, good dispersion are used as extensively
The functional products such as washing, emulsification, solubilising, moisturizing, not only surface tension is low for it, and foaming abundancy is fine and smooth and stablizes, and decontamination is excellent, and
And compatibility is splendid.It is the unique kind that can really deserve to be called " world-class " surfactant.Since pure natural raw material is made
APG unique superior function, domestic external application APG shows good skin as novel cosmetic made of active component
Moisture retention and skin care performance.In terms of food emulsifying agent, APG has with compared with food emulsifying agent (such as glycerine fatty acid)
There is the same or similar property.China's food emulsifying agent is not only solved using APG as food emulsifying agent there was only lipophilicity
The problem of (HLB5-9) product, also increase the kind of food emulsifying agent.
3. compound cassia bark nano-emulsion of the present invention since fine droplet is in strong permeability, there is easy absorption, enhancing effect reduces poison
The advantage of side effect plays the role of preventing bite by mosquitos and bites caused pruitus, redness, even inflammation.
Detailed description of the invention
Fig. 1 is compound cassia bark oil nanometer emulsion aspect graph under transmission electron microscope.
Fig. 2 is compound cassia oil nano-emulsion particle diameter distribution map.
Fig. 3 is compound cassia bark oil nanometer emulsion zata potential image.
Specific embodiment
Embodiment one:
A kind of compound cassia bark oil nanometer emulsion, is made of, wherein vegetable oil vegetable oil, organic materials, deionized water and auxiliary material
In include according to cassia oil that weight part ratio is 1:2:5 configuration, samara oil, peppermint oil, vegetable oil accounts for nano-emulsion weight percent
It is 4.0%, organic materials includes the alkyl glycosides configured according to weight part ratio for 4:2,1,2-PD, and organic materials accounts for nanometer
Newborn weight percent is 40%；It is 35% that deionized water, which accounts for nano-emulsion weight percent,；Auxiliary material includes caprylic/capric glycerol three
Ester, SCY, vitamin E, Dermosoft Eco 1388 and citric acid, caprylic/capric triglyceride account for nano-emulsion weight percent
Accounting for nano-emulsion weight percent for 2.0%, SCY is 0.8%, and it is 0.2% that vitamin E, which accounts for nano-emulsion weight percent,
It is 3.0% that Dermosoft Eco 1388, which accounts for nanoemulsion weight ratio, and it is 15% that citric acid, which accounts for nano-emulsion weight percent,.
Embodiment two:
A kind of compound cassia bark oil nanometer emulsion, it is characterised in that it is made of vegetable oil, organic materials, deionized water and auxiliary material,
It wherein include the cassia oil configured according to weight part ratio for 2:4:2, samara oil, peppermint oil in vegetable oil, vegetable oil accounts for nano-emulsion
Weight percent is 6.0%, organic materials include according to weight part ratio be 5:1 configuration alkyl glycosides, 1,2-PD, it is organic
It is 35% that material, which accounts for nano-emulsion weight percent,；It is 40% that deionized water, which accounts for nano-emulsion weight percent,；Auxiliary material includes octanoic acid/last of the ten Heavenly stems
Acid glycerol three ester, SCY, vitamin E, Dermosoft Eco 1388 and citric acid, caprylic/capric triglyceride account for nano-emulsion weight
Amount percentage is that account for nano-emulsion weight percent be 0.9% to 4.0%, SCY, and vitamin E accounts for nano-emulsion weight percent and is
It is 4.0% that 0.1%, Dermosoft Eco 1388, which accounts for nanoemulsion weight ratio, and citric acid accounts for nano-emulsion weight percent and is
10%.
Embodiment three:
A kind of compound cassia bark oil nanometer emulsion, it is characterised in that it is made of vegetable oil, organic materials, deionized water and auxiliary material,
It wherein include the cassia oil configured according to weight part ratio for 4:2:2, samara oil, peppermint oil in vegetable oil, vegetable oil accounts for nano-emulsion
Weight percent is 2.0%, organic materials include according to weight part ratio be 6:1 configuration alkyl glycosides, 1,2-PD, it is organic
It is 30% that material, which accounts for nano-emulsion weight percent,；It is 45% that deionized water, which accounts for nano-emulsion weight percent,；Auxiliary material includes octanoic acid/last of the ten Heavenly stems
Acid glycerol three ester, SCY, vitamin E, Dermosoft Eco 1388 and citric acid, caprylic/capric triglyceride account for nano-emulsion weight
Amount percentage is that account for nano-emulsion weight percent be 0.5% to 6.0%, SCY, and vitamin E accounts for nano-emulsion weight percent and is
It is 5.0% that 0.05%, Dermosoft Eco 1388, which accounts for nanoemulsion weight ratio, and citric acid accounts for nano-emulsion weight percent and is
11.45%.
Example IV:
A kind of compound cassia bark oil nanometer emulsion, it is characterised in that it is made of vegetable oil, organic materials, deionized water and auxiliary material,
It wherein include the cassia oil configured according to weight part ratio for 6:1:3, samara oil, peppermint oil in vegetable oil, vegetable oil accounts for nano-emulsion
Weight percent is 8.0%, organic materials include according to weight part ratio be 6:2 configuration alkyl glycosides, 1,2-PD, it is organic
It is 30% that material, which accounts for nano-emulsion weight percent,；It is 35% that deionized water, which accounts for nano-emulsion weight percent,；Auxiliary material includes octanoic acid/last of the ten Heavenly stems
Acid glycerol three ester, SCY, vitamin E, Dermosoft Eco 1388 and citric acid, caprylic/capric triglyceride account for nano-emulsion weight
Amount percentage is that account for nano-emulsion weight percent be 1.0% to 2.85%, SCY, and vitamin E accounts for nano-emulsion weight percent and is
It is 3.0% that 0.15%, Dermosoft Eco 1388, which accounts for nanoemulsion weight ratio, and citric acid accounts for nano-emulsion weight percent and is
20%.
Embodiment five:
A kind of compound cassia bark oil nanometer emulsion, it is characterised in that it is made of vegetable oil, organic materials, deionized water and auxiliary material,
It wherein include the cassia oil configured according to weight part ratio for 4:2:3, samara oil, peppermint oil in vegetable oil, vegetable oil accounts for nano-emulsion
Weight percent is 4.0%, organic materials include according to weight part ratio be 4:1 configuration alkyl glycosides, 1,2-PD, it is organic
It is 35% that material, which accounts for nano-emulsion weight percent,；It is 35% that deionized water, which accounts for nano-emulsion weight percent,；Auxiliary material includes octanoic acid/last of the ten Heavenly stems
Acid glycerol three ester, SCY, vitamin E, Dermosoft Eco 1388 and citric acid, caprylic/capric triglyceride account for nano-emulsion weight
Amount percentage is that account for nano-emulsion weight percent be 5.0% to 2.8%, SCY, and vitamin E accounts for nano-emulsion weight percent and is
It is 3.0% that 0.2%, Dermosoft Eco 1388, which accounts for nanoemulsion weight ratio, and citric acid accounts for nano-emulsion weight percent and is
15%.
Embodiment six:
A kind of compound cassia bark oil nanometer emulsion, it is characterised in that it is made of vegetable oil, organic materials, deionized water and auxiliary material,
It wherein include the cassia oil configured according to weight part ratio for 6:2:2, samara oil, peppermint oil in vegetable oil, vegetable oil accounts for nano-emulsion
Weight percent is 8.0%, organic materials include according to weight part ratio be 5:2 configuration alkyl glycosides, 1,2-PD, it is organic
It is 30% that material, which accounts for nano-emulsion weight percent,；It is 40% that deionized water, which accounts for nano-emulsion weight percent,；Auxiliary material includes octanoic acid/last of the ten Heavenly stems
Acid glycerol three ester, SCY, vitamin E, Dermosoft Eco 1388 and citric acid, caprylic/capric triglyceride account for nano-emulsion weight
Amount percentage is that account for nano-emulsion weight percent be 3.0% to 3.8%, SCY, and vitamin E accounts for nano-emulsion weight percent and is
It is 5.0% that 0.2%, Dermosoft Eco 1388, which accounts for nanoemulsion weight ratio, and citric acid accounts for nano-emulsion weight percent and is
10%.
The preparation method of above-mentioned compound cassia bark oil nanometer emulsion, comprising the following steps:
Step 1: cassia oil, samara oil, peppermint oil are weighed according to weight part ratio for 1~6:1~4:2~5, then mix
It closes, stir evenly, sequentially add caprylic/capric triglyceride and vitamin E, stir evenly, obtain A phase；By alkyl glycosides,
1,2-PD is that 4~6:1~2 weigh according to weight part ratio, then mixes, stirs evenly, obtains B phase；While stirring by A phase
It is added in B phase and stirs evenly, obtain A/B phase；It is made above can be at 20 DEG C~30 DEG C, revolving speed is 800rpm~1200rpm
Stirring condition under carry out；
Step 2: the SCY for weighing prescription amount is add to deionized water and stirs evenly, C phase is obtained, deionized water used
Amount is the 3/4 of deionized water full dose；C phase is delayed under 25 DEG C~35 DEG C, the stirring condition that revolving speed is 1500rpm~3000rpm
Slowly it is homogeneously added into above-mentioned A/B phase, then Dermosoft Eco 1388 is slowly added dropwise, continue 5~10min of stirring to system
As the clear and bright shape lotion of yellow, D phase is obtained；
It is dissolved in D phase step 3: weighing citric acid, finally plus pure remaining deionized water, stirs evenly, adjust the pH of D phase
To 5.0~6.0, compound cassia bark oil nanometer emulsion is obtained.
1. the itching-relieving action of compound cassia bark nano-emulsion is investigated
It chooses healthy mice and is randomly divided into 3 groups, is i.e. blank control group, compound cassia bark nano-emulsion group, compound cassia bark is common
Newborn group.Every group at mouse part skin shaving area coating 1 time.30min is subcutaneously injected to 4-aminopyridine at shaving after administration,
Blank control group injects isometric(al) physiological saline.Record the number of groups of animals Licking response in 10min after injecting 4-AP.Number
According to using SPSS11.0 analysis software.Test result is shown in Table 1.
The 1 antipruritic test result of compound cassia bark nano-emulsion of table
Seen from table 1, compound cassia bark nano-emulsion group, compound cassia bark commonly newborn group to mouse scabies caused by 4-aminopyridine
The inhibiting rate itched is respectively 55.88% and 32.35%, it is seen that the antipruritic effect of compound cassia bark nano-emulsion group is substantially better than compound osmanthus
The common newborn group of skin.
2. the anti-inflammatory effect of compound cassia bark nano-emulsion
It chooses healthy mice and is randomly divided into 3 groups, is i.e. blank control group, compound cassia bark nano-emulsion group, compound cassia bark is common
Newborn group.Mouse or so ear is using dimethylbenzene as proinflammatory agent.Each group drug is uniformly applied to mouse or so ear front and back two sides respectively, 1h gives
Medicine is primary, successive administration 8h.Using dimethylbenzene as proinflammatory agent, after last dose 1h, mouse is anesthetized with ether, on every mouse right side
The front and back two sides of ear is coated with proinflammatory agent 0.02ml, and left ear compares.Using the weight differential of two auricles as swelling, swelling suppression is calculated
Rate [inhibiting rate (%)=(one experimental group swelling of blank control group swelling)/blank control group swelling × 100%] processed.It adopts
With SPSS ll.0 analysis software statistics analysis, it the results are shown in Table 2.
2 compound cassia bark nano-emulsion of table investigates the anti-inflammatory effect of mouse
As can be seen from Table 2, compound cassia bark nano-emulsion and the common cream of compound cassia bark can inhibit mouse ear caused by dimethylbenzene and swell
Swollen, inhibiting rate is respectively 87.0% and 71.9%, and blank control group is without apparent antiphlogistic effects.It can be seen that compound cassia bark nano-emulsion
Antiphlogistic effects better than compound cassia bark it is commonly newborn.
Inflammation is the reaction for having the living tissue of vascular system to local damage.Early stage inflammation, certain inflammation are situated between
Matter stimulates blood vessel, distends the blood vessels, and vascular endothelial gap expands, Vascular Permeability enhancing, the liquid in blood plasma, protein and
Leucocyte etc. is exuded to tissue space, with the increase of exudation, causes swollen tissue, and therefore, inflammatory exudation swollen tissue is scorching
The important indicator of disease early stage.Inflammatory mediator refers to one group under pro-inflammatory cytokine effect, is generated and is discharged by local organization or blood plasma
Participation inflammatory reaction, and with proinflammatory effect chemically reactive substance.It is divided into two classes by its source, one kind is that pro-inflammatory cytokine is straight
It connects or indirectly-acting is in histocytes such as leucocyte, mast cell, macrophage and blood platelets, be allowed to the tissues-derived inflammation generated
Disease medium, such as histamine, prostaglandin, leukotriene, lysosome composition and lymphokine；One kind is the blood plasma from blood plasma components
Source property inflammatory mediator.The present invention, which tests, selects mice caused by dimethylbenzene xylene auricle edema, has studied compound cassia bark nano-emulsion to tissue source
Property inflammatory mediator caused by inflammation anti-inflammatory effect the results show that compound cassia bark nano-emulsion have significant anti-inflammatory effect.
In short, compound cassia bark nano-emulsion of the present invention has significant anti-bite by mosquitos antipruritic and anti-inflammatory treatment effect, and institute
Environmentally protective with material, preparation method is easy, and preparation stabilization is suitable for realizing industrialized production.
Claims (2)
1. a kind of compound cassia bark oil nanometer emulsion, it is characterised in that it is made of vegetable oil, organic materials, deionized water and auxiliary material,
By being that cassia oil, samara oil, peppermint oil that 1 ~ 6:1 ~ 4:2 ~ 5 is configured form according to weight part ratio, vegetable oil accounts for be received middle vegetable oil
Rice milk weight percent is 2.0% ~ 8.0%, and organic materials is by according to the alkyl glycosides that weight part ratio is the configuration of 4 ~ 6:1 ~ 2,1,2-
Propylene glycol composition, it is 30% ~ 40% that organic materials, which accounts for nano-emulsion weight percent,；Deionized water accounts for nano-emulsion weight percent
35%~45%；Auxiliary material is by caprylic/capric triglyceride, camellia oil SCY, vitamin E, Dermosoft Eco 1388 and citric acid
Composition, it is that 2.0% ~ 6.0%, SCY accounts for nano-emulsion weight percent and is that caprylic/capric triglyceride, which accounts for nano-emulsion weight percent,
0.5% ~ 5.0%, it is that 0.05% ~ 0.2%, Dermosoft Eco 1388 accounts for nanoemulsion that vitamin E, which accounts for nano-emulsion weight percent,
Weight ratio is 3.0% ~ 5.0%, and it is 10% ~ 20% that citric acid, which accounts for nano-emulsion weight percent,.
2. a kind of preparation method of compound cassia bark oil nanometer emulsion as described in claim 1, it is characterised in that the following steps are included:
Step 1: cassia oil, samara oil, peppermint oil are weighed according to weight part ratio for 1 ~ 6:1 ~ 4:2 ~ 5, then mixes, stirs
Uniformly, caprylic/capric triglyceride and vitamin E are sequentially added, is stirred evenly, A phase is obtained；By alkyl glycosides, 1,2- third
Glycol is that 4 ~ 6:1 ~ 2 weigh according to weight part ratio, then mixes, stirs evenly, obtains B phase；A phase is added to B while stirring
It in phase and stirs evenly, obtains A/B phase；It is made above at 20 DEG C ~ 30 DEG C, revolving speed is the stirring condition of the rpm of 800rpm ~ 1200
Lower progress；
Step 2: the SCY for weighing prescription amount is add to deionized water and stirs evenly, C phase is obtained, the amount of deionized water used is
The 3/4 of deionized water full dose；C phase is slowly uniform under 25 DEG C ~ 35 DEG C, the stirring condition that revolving speed is the rpm of 1500rpm ~ 3000
Ground is added in above-mentioned A/B phase, then Dermosoft Eco 1388 is slowly added dropwise, and continuing 5 ~ 10min of stirring to system becomes yellow
The clear and bright shape lotion of color, obtains D phase；
Be dissolved in D phase step 3: weighing citric acid, finally plus remaining deionized water, stir evenly, adjust the pH to 5.0 of D phase ~
6.0, obtain compound cassia bark oil nanometer emulsion.
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| CN110548164A (en) * | 2019-10-24 | 2019-12-10 | 南京启景环境科技有限公司 | Plant extraction compound nano material for air purification |
| CN112156053A (en) * | 2020-10-22 | 2021-01-01 | 北京中康联健康科技有限公司 | European cowberry fruit water-luster composition and preparation method thereof |
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| CN101002827A (en) * | 2006-12-15 | 2007-07-25 | 江南大学 | Micro-emulsion of mint oil with slow-releasing property, and its preparing method |
| CN101214355A (en) * | 2007-12-29 | 2008-07-09 | 西北农林科技大学 | Compound eugenol nano emulsion composition and preparation thereof |
| WO2011004395A1 (en) * | 2009-07-06 | 2011-01-13 | Intas Biopharmaceuticals Limited | Microemulsion formulation for biologicals |
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| CN101002827A (en) * | 2006-12-15 | 2007-07-25 | 江南大学 | Micro-emulsion of mint oil with slow-releasing property, and its preparing method |
| CN101214355A (en) * | 2007-12-29 | 2008-07-09 | 西北农林科技大学 | Compound eugenol nano emulsion composition and preparation thereof |
| WO2011004395A1 (en) * | 2009-07-06 | 2011-01-13 | Intas Biopharmaceuticals Limited | Microemulsion formulation for biologicals |
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| 国家食品药品监督管理总局关于批准翅果油作为化妆品原料使用的公告（第51号）;国家食品药品监督管理总局;《http://www.sda.gov.cn/WS01/CL0087/108721.html》;20141030;第1页，附件第2页倒数第2行、第3页第1行 |
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