CN107468609A - A kind of skin repair composition for after bite by mosquitos and the aqueous based systems containing this kind of composition - Google Patents
A kind of skin repair composition for after bite by mosquitos and the aqueous based systems containing this kind of composition Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
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Abstract
It is specially a kind of for playing antipruritic and maintenance skin composition, and the aqueous based systems containing this kind of composition after bite by mosquitos the present invention relates to daily chemical product technical field.Menthol in the present composition and aqueous based systems can provide refrigerant sense, can rapid recovery or dilution scratchiness by, though the content of menthol is less than 2% in aqueous based systems, but pass through the appropriate compounding with other components, coordinative role between each component, still ensure that product has good relieving itching and eliminating swelling effect.Though the present invention is the aqueous based systems of no ethanol, but not there is the problem of menthol crystallization is separated out during low temperature (0 10 DEG C), thus it is more extensive for aqueous based systems of the present invention, the selection of packaging material, transparent packaging material such as can be selected, it is not necessary to worry that consumer changes to product appearance and produce worry.
Description
Technical field
Play antipruritic after being used for bite by mosquitos the present invention relates to daily chemical product technical field, more particularly to one kind and repair
The composition of sheath skin, and the aqueous based systems containing this kind of composition.
Background technology
Mosquito enters skin histology by its mouthpart prick into human body's skin, its saliva and secretion, and skin can be to outside these
Derived component (antigen or allergen) produces allergic reaction so as to cause inflammation, and appearance is exactly itch redness, and
The performance of the skin of infant and children can be more obvious.Some commercial antipruritic medicines with Quick itch stopping and can eliminate redness,
Main component is paralyzant and antiphlogistic, it is known that example include antihistaminic, such as bagodryl hydrochloride and steroids (such as acetic acid
Dexamethasone etc.), anesthetic such as procaine, totokaine, cinchocaine, lidocaine.These antipruritic medicines are although quick
But dependence is easily produced, and also has side effect.Although some commercial household chemicals have much declares have
Relieving itching and eliminating swelling effect, but most actions are slow, and antipruritic effect is bad, and Aloe Extract effect is undesirable.The preferable product of some effects is more
Number has used the menthol, camphor or borneol of high level, and ethanol of arranging in pairs or groups is this kind of as solvent, the use of high level
Material will necessarily cause stronger skin irritation, can may temporarily solve the problems, such as itch redness, but can bring skin sensitivity
Or the other problems such as shouting pain.In addition, there is some products to be compounded using menthol and extract, alcohol-free system is prepared into, this
The alcohol-free system product common problem of class is that system can at a lower temperature (0-10 DEG C) when menthol content is higher
Crystallization is separated out, influences outward appearance, and limit the use of packaging material；If reducing the content of menthol, relieving itching and eliminating swelling effect can also drop
Low, formulation selection is very limited.
Correlative technology field personnel are also hopeful solve the skin after bite by mosquitos by the compound mode of some compositions
Skin problem, the technical staff of some field of medicaments treat pruitus, such as patent publication by the compounding of Chinese medicine
CN201210258152.2, CN201510905942.9, CN201610367963.4, in using in these patent publications
Medicine composition up to ten tastes are to more than ten tastes, although there is preferable effect, cross the use of multiple types Chinese medicine, its non-principal component is brought
Risk can not be ignored, and excessively multicomponent these compositions of operation instruction simply simple mixing, to wherein specifically acting as
Material and how to solve the problems, such as the unknown of source at all.Patent publication 201510643722.3 is disclosed for mosquito
The antipruritic composition of sting, compounded using menthol and plant component, menthol usage amount is 1-5% in composition, is belonged to
High level scope, damaged skin will have stronger excitant when menthol content is higher than 2%, because the rush of menthol is oozed
Permeability energy, the camphor compounded in composition can increase the excitant of whole composition with ethanol, be not appropriate for that consumer is daily to be made
With.Patent publication 201210460995.0 discloses a kind of preparation of argy wormwood Flos Lonicerae extractive solution, by folium artemisiae argyi, honeysuckle,
Chrysanthemum, peppermint are carried out the effect of compounding use reaches removing miliaria and relieving itching, but the extracting mode of these plant extracts is still using biography
The decoction of system or steam distillation, it is known that the active component in above plant extracts is belonged to heat and oxygen sensitivity
Composition, using these extracting modes, active component therein is largely destroyed, and obtain using steam distillation mode
The content of the menthol content arrived in the mixture is very low, and the itching-relieving efficacies of said composition are worth discussion from technique.Patent
CN201210568326.5 discloses triclosan, sodium acid carbonate, ammoniacal liquor, tea oil, the anti-pruritic formulation of menthol composition, but according to grinding
Study carefully and show, product of the Long Term Contact containing triclosan, the resistance to the action of a drug or hormonal readiness of human body can be influenceed, bring health risk, and
And FDA has had been sent from prohibitting the use of the requirement of triclosan in some daily chemical products.
The content of the invention
It is an object of the invention to for the product that is currently used for using after bite by mosquitos exist it is big to skin irritation or
Relieving itching and eliminating swelling is ineffective or the problem of alcohol-free system product can separate out peppermint alcohol crystals at low ambient temperatures, there is provided Yi Zhongyong
Used after bite by mosquitos and menthol content is low but relieving itching and eliminating swelling effect is good composition, and contain this kind of composition and low
The alcohol-free aqueous based systems of peppermint alcohol crystals will not be separated out under warm environment.
To achieve the above object, the present invention uses following technical scheme.
A kind of skin repair composition being used for after bite by mosquitos, each component containing following parts by weight：
Menthol 0.1-2 parts；
Honegsukle flower P.E 0.05-10 parts；
Both A. absinthium extract 0.05-18 parts；
Phragmites communis extract 0.1-10 parts；
Tuckahoe extracts 0.1-10 parts；
Radix glycyrrhizae class material 0.05-20 parts, the radix glycyrrhizae class material are selected from glycyrrhizic acid, glycyrrhetate, enoxolone and radix glycyrrhizae
At least one of secondary hydrochlorate；
The Honegsukle flower P.E, both A. absinthium extract, phragmites communis extract and tuckahoe extracts are water-soluble
Extract.
The skin repair composition being used for after bite by mosquitos, the parts by weight of contained each component are preferably as follows：
Menthol 0.1-2 parts；
Honegsukle flower P.E 0.05-5 parts；
Both A. absinthium extract 0.05-10 parts；
Phragmites communis extract 1.5-4 parts；
Tuckahoe extracts 3-10 parts；
Radix glycyrrhizae class material 0.05-10 parts.
Preferably, the menthol is Natural menthol and/or levorotatory menthol.The use of menthol can be with rapid dilution
Or change the scratchiness of skin by by controlling the mass percent of menthol in aqueous based systems of the present invention to be less than 2%, it is ensured that
The uniformity that refrigerant sense is received, if the adding too much of menthol can make refrigerant sense to change into burning heat sensation or tingling sensation and cause skin
Skin stimulates.Meanwhile menthol can change the conformation of lipid in cuticula, increase the mobility of Stratum corneum lipids bilayer
Add, the change of orderly compact texture, reduce skin barrier effect, can promote skin to honeysuckle extraction using menthol in right amount
The absorption of active component, promotes the performance of effect in thing, both A. absinthium extract, phragmites communis extract and tuckahoe extracts.It is excessive
Use (be higher than 2%) destructiveness of skin barrier can be aggravated, be unfavorable for the skin repair after bite by mosquitos.
Preferably, the Honegsukle flower P.E is honeysuckle by low temperature water extraction and is spray-dried obtained water soluble powder
End；It is furthermore preferred that the recovery rate of the Honegsukle flower P.E is 20-10:1.The Honegsukle flower P.E powder obtained by the technique
The chlorogenic acid containing high level, cyanidenon, galuteolin, rutin, inositol, macromolecular polysaccharide class material etc., can have in end
Effect suppresses the itch medium of keratinocyte release, and effectively facilitates skin barrier reparation.Human body skin is by after bite by mosquitos
The histamine of body release can allow Vascular Permeability to increase, and tissue fluid oozes out, and skin surface, which will show, itches with red and swollen, skin
Skin barrier function weakens, and skin surface ecological environment can also change, and the use of Honegsukle flower P.E can effectively suppress gold
Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, streptococcus pyogenes, effectively prevent inflammation caused by pathogenic bacteria.
Preferably, the both A. absinthium extract is that both A. absinthium is through microwave using glycerine, water and butanediol as mixed solvent
Extract obtained water-soluble filtrate.The Flavonoid substances such as rutin containing high level, energy in the both A. absinthium that the technique obtains
Vascular Permeability and brittle effect are enough reduced, recovers the elasticity of blood vessel, effectively prevents oozing out for tissue fluid after bite by mosquitos,
Mitigate the enclosed mass after bite by mosquitos to expand, play synergy with Honegsukle flower P.E compounding, both can effectively suppress compounding
The pathogenic bacteria of skin increase at bite by mosquitos, and effectively suppress the expansion of enclosed mass and red and swollen area.
Preferably, the phragmites communis extract is to extract the water-soluble filter that reed obtains at normal temperatures using buffered aqueous solvent
Liquid.The tuckahoe extracts are to extract the water-soluble filtrate that Poria cocos obtains at normal temperatures using buffered aqueous solvent.Carried by this kind
Taking technique can effectively preserve the active ingredients such as Coixol in phragmites communis extract, D-Glucose, D- galactolipins, to bite by mosquitos
Skin afterwards can play sedation, reduce scratchiness, and can promote skin barrier reparation.This kind of extraction process can have
Effect preserves su-fuling, pachymaran isoreactivity composition in tuckahoe extracts, can effectively anti-oxidant, anti-inflammatory, support barrier work(
Can and help skin solve it is hypertonic stress when deficiency, promote the reparation in bite by mosquitos affected part.Phragmites communis extract extracts with Poria cocos
Thing compounding use can effectively suppress itch, allergy and the inflammation of the histamine because of mast cell release.
Contained radix glycyrrhizae class material has the function that effective anti-oxidant, antiallergy, anti-inflammatory in the present composition, can delay
Excessive skin allergic reaction after solution bite by mosquitos, has the activity of Synergistic suppression tyrosinase with tuckahoe extracts, has
Effect alleviates the pigmentation after bite by mosquitos.
A kind of aqueous based systems containing the skin repair composition described above for after bite by mosquitos, by following quality hundred
Divide each component composition of ratio：
For the skin repair composition 1-50% after bite by mosquitos；
1,3 butylene glycol 5-40%；
Solubilizer 0.2-10%；
Cosolvent 0.1-7%；
Surplus is water.
The aqueous based systems containing for the skin repair composition after bite by mosquitos, the quality percentage of contained each component
Than being preferably as follows：
For the skin repair composition 1-30.5% after bite by mosquitos；
1,3 butylene glycol 10-20%；
Solubilizer 0.6-5%；
Cosolvent 3-7%；
Surplus is water.
Preferably, the water is deionized water.
Preferably, the solubilizer be selected from Cremophor RH40, PEG-60 rilanit specials, polysorbate -20,
Polysorbate -40, Polyoxyethylene Sorbitan Monooleate, laureth -23, PPG-5 ceteths -20, oleth -20, PEG-
6 caprylic/capric glyceride types, PEG-7 glyceryl cocoates, PEG-60 passionflowers glyceride type, PEG-45 palm oil glycerides
At least one of class, PEG-60 almond glyceride types.Such solubilizer property is gentle, can directly contact skin, to skin without
Stimulate, do not interfere with the reparation for biting rear skin.
Preferably, the cosolvent is polarity grease and/or C12-18 Pareths.
It is furthermore preferred that the polarity grease is selected from Permethyl 99A, isohexadecane, octyl dodecanol, C12-15 alcohol benzoic acid
Ester, adipic acid ethylhexyl, ethyl oleate, isopropyl isostearate, n-nonanoic acid ethylhexyl, diethyl hexylcarbonate, poly- third
At least one of the nutmeg of glycol -3 alcohol ether, decyl oleate, benzene oxygen ethyl octanoic acid.Polarity grease described above is more than 0 DEG C
Be mobility liquid, and there is good solvability to menthol, can ensure under appropriate ratio more than 0 DEG C it is right
The solubility of menthol, such polar solvent property are gentle, non-stimulated to skin.
It is furthermore preferred that the C12-18 Pareths are as nonionic surfactant, HLB value 5-9.5, selected from the moon
Laureth -2, laureth -3, laureth -4, C12-13 Pareths -2, C12-13 Pareths -3,
At least one of C12-13 Pareths -4, oleth -2, oleth -3, oleth -4, oleth -5.
It is furthermore preferred that the C12-18 Pareths are working fluid at normal temperatures.
Above-described C12-18 Pareths have a more preferable oleophilic properties, at the same its surfactant properties and
Excellent solvability, it can be cooperateed with different temperature conditionss by changing the dissolved state of micellar conformation and menthol
Solubilizer solubilising, ensure that under appropriate proportioning composition in the transparency of aqueous based systems, can make formula 0 under the conditions of alcohol-free
DEG C clear.
Contained 1,3 butylene glycol can not only keep the product shape under cryogenic conditions in aqueous based systems of the present invention
State, increase micelle volume in fence structure that can also be by inserting surfactant, improve the characteristic of solubilizing of solubilizer.1,3-
Butanediol has certain solvability to menthol in itself, can help to improve the stability under cryogenic conditions.1,3 butylene glycol
The moisture of skin can be also improved as NMF, promotes the reparation in affected part.
The above-described aqueous based systems containing for the skin repair composition after bite by mosquitos, can also be according to product
Performance requirement and add other additives, such as pH buffer, essence, preservative, xanthans, card ripple.
Compared with prior art, the beneficial effects of the invention are as follows：
Menthol in the present composition and aqueous based systems can provide refrigerant sense, can rapid recovery or dilution scratchiness
By, though the content of menthol is less than 2% in aqueous based systems, by the appropriate compounding with other components, the association between each component
Tune acts on, and still ensures that product has good relieving itching and eliminating swelling effect.
Due to that can produce a series of dermoreaction after bite by mosquitos, itch, then played bag before this, then red and swollen, single
The combination of functional component or effect analogous components can not solve problem at all.The present composition goes out from the red and swollen root of itch
Hair, Reduced Design, from refrigerant, calm, antibacterial, anti-inflammatory, suppress the formation of itch medium, antiallergy, suppression pigmentation, reduction group
The skin problem after the various dimensions such as the oozing out of liquid, skin barrier reparation confrontation bite by mosquitos is knitted, effectively solves itch, enclosed mass, red
The problems such as swollen.In the present invention, menthol provides refrigerant sense and promotes active component to permeate, and Honegsukle flower P.E extracts with Poria cocos
Both things suppress itch, the work of Central Asia biennial wormwood extract for keratinocyte and the itch medium of mast cell release respectively
With the bag that disappears is laid particular emphasis on, radix glycyrrhizae class material lays particular emphasis on suppression allergy, and phragmites communis extract lays particular emphasis on reparation skin barrier, this six kinds of components
Combination play synergy, the missing of any component all can reducing effect.
Used by the extract that the present invention uses extracting method can maximum retentive activity composition stabilization, have
The effect of beneficial to product of the present invention is ensured.
The skin repair composition of the present invention can be prepared into by transparent aqua by the method for routine, i.e., it is of the present invention
Aqueous based systems, and (be higher than 0 DEG C) under cryogenic and remain to keep transparent aqua character.The aqueous based systems of the present invention make peppermint
Alcohol has broken away from the dependence to ethanol in aqueous based systems, and solves low temperature crystallization precipitation of the menthol in without ethanol system and ask
Topic.Though the present invention is the aqueous based systems of no ethanol, but not there is the problem of menthol crystallization is separated out during low temperature (0-10 DEG C), because
, for aqueous based systems of the present invention, the selection of packaging material is more extensive, transparent packaging material such as can be selected, it is not necessary to worry consumer to product for this
Cosmetic variation produces worry.
Embodiment
In order to more fully understand the technology contents of the present invention, with reference to specific embodiment to technical scheme
It is described further and illustrates.
For those skilled in the art, it is feature of the invention, beneficial by reading the content of this disclosure
Effect and advantage will become obvious.
Except as otherwise noted, all percentages, fraction and ratio are calculated by the gross weight of the present composition.Remove
Non- otherwise indicated, all wt about ingredients listed gives the content of active material, thus they be not included in it is commercially available
The solvent or accessory substance that may be included in the material of acquisition.This paper terms " weight content " available symbols " % " represent.
Herein " comprising ", "comprising", " containing ", " containing ", " having " or other variants be intended to it is non-enclosed including,
Do not distinguished between these terms.Term "comprising" refers to that the other steps for not influenceing final result and composition can be added.Term
"comprising" also includes term " Consists of " and "consisting essentially of ...".The compositions and methods of the invention/technique can include,
It is made from it and substantially by essential elements described herein and limit entry and described herein any additional or optional
Composition, component, step or limit entry composition.
The menthol used in following embodiments is Natural menthol and/or levorotatory menthol.
Honegsukle flower P.E, both A. absinthium extract, phragmites communis extract, the tuckahoe extracts used in following embodiments should
Meet following require：
Honegsukle flower P.E is honeysuckle by low temperature water extraction (such as Extracting temperature is not higher than 25 DEG C) and is spray-dried
The water-soluble powder arrived；The recovery rate of Honegsukle flower P.E is 20-10:1 (honeysuckle raw material and extraction gained water-soluble powder
Mass ratio).
Both A. absinthium extract is using glycerine, water and butanediol as mixed solvent, and both A. absinthium obtains through Microwave Extraction
Water-soluble filtrate.
Phragmites communis extract is to extract the water-soluble filtrate that reed obtains at normal temperatures using buffered aqueous solvent.
Tuckahoe extracts are to extract the water-soluble filtrate that Poria cocos obtains at normal temperatures using buffered aqueous solvent.
Embodiment 1
The present embodiment provides a kind of skin repair composition being used for after bite by mosquitos, and the water containing this kind of composition
Matrix system.
It is made up of for the skin repair composition after bite by mosquitos each component of following parts by weight：0.1 part of menthol, gold
0.15 part of honeysuckle flower extract, 0.3 part of both A. absinthium extract, 0.1 part of phragmites communis extract, 0.1 part of tuckahoe extracts, glycyrrhizic acid
0.25 part.
Containing the aqueous based systems described in the present embodiment for the skin repair composition after bite by mosquitos by following parts by weight
Each component form：For 1 part of skin repair composition after bite by mosquitos, 5 parts of 1,3-BDO, PEG-60 rilanit specials
3 parts, -3 3 parts of C12-13 Pareths, 0.1 part of pH buffer, 0.01 part of essence, 0.5 part of preservative, deionized water surplus；
The total amount of the aqueous based systems formed is 100 parts.
For the skin repair composition after bite by mosquitos and containing described in the present embodiment be used for bite by mosquitos after skin
The preparation method of the aqueous based systems of skin maintenance composition：Each raw material is conventionally well mixed, can obtain clear
Solution.
Embodiment 2
The present embodiment provides a kind of skin repair composition being used for after bite by mosquitos, and the water containing this kind of composition
Matrix system.
It is made up of for the skin repair composition after bite by mosquitos each component of following parts by weight：1 part of menthol, gold and silver
2 parts of flower extract, 0.05 part of both A. absinthium extract, 1.5 parts of phragmites communis extract, 3 parts of tuckahoe extracts, enoxolone 0.05
Part.
Containing the aqueous based systems described in the present embodiment for the skin repair composition after bite by mosquitos by following parts by weight
Each component form：For 7.6 parts of skin repair composition after bite by mosquitos, 20 parts of 1,3-BDO, carbonic acid diethyl oneself
1 part of ester, -20 3 parts of PPG-5 ceteths, 3 parts of PEG-60 rilanit specials, 3 parts of laureth -4, pH buffer
0.05 part, 0.45 part of xanthans, 0.1 part of essence, 0.05 part of preservative, deionized water surplus；The aqueous based systems formed it is total
Measure as 100 parts.
For the skin repair composition after bite by mosquitos and containing described in the present embodiment be used for bite by mosquitos after skin
The preparation method of the aqueous based systems of skin maintenance composition：Each raw material is conventionally well mixed, can obtain clear
Solution.
Embodiment 3
The present embodiment provides a kind of skin repair composition being used for after bite by mosquitos, and the water containing this kind of composition
Matrix system.
It is made up of for the skin repair composition after bite by mosquitos each component of following parts by weight：0.1 part of menthol, gold
3 parts of honeysuckle flower extract, 10 parts of both A. absinthium extract, 3 parts of phragmites communis extract, 3 parts of tuckahoe extracts, 0.5 part of enoxolone.
Containing the aqueous based systems described in the present embodiment for the skin repair composition after bite by mosquitos by following parts by weight
Each component form：For 19.6 parts of skin repair composition after bite by mosquitos, 10 parts of 1,3-BDO, PEG-60 almonds are sweet
0.2 part of grease class, 0.1 part of PEG-6 caprylic/caprics glyceride type, 0.2 part of laureth -2,0.08 part of pH buffer are fragrant
0.2 part of essence, deionized water surplus；The total amount of the aqueous based systems formed is 100 parts.
For the skin repair composition after bite by mosquitos and containing described in the present embodiment be used for bite by mosquitos after skin
The preparation method of the aqueous based systems of skin maintenance composition：Each raw material is conventionally well mixed, can obtain clear
Solution.
Embodiment 4
The present embodiment provides a kind of skin repair composition being used for after bite by mosquitos, and the water containing this kind of composition
Matrix system.
It is made up of for the skin repair composition after bite by mosquitos each component of following parts by weight：2 parts of menthol, gold and silver
5 parts of flower extract, 10 parts of both A. absinthium extract, 3 parts of phragmites communis extract, 10 parts of tuckahoe extracts, 0.5 part of dipotassium glycyrrhizinate.
Containing the aqueous based systems described in the present embodiment for the skin repair composition after bite by mosquitos by following parts by weight
Each component form：For 30.5 parts of skin repair composition after bite by mosquitos, 20 parts of 1,3-BDO, C12-15 alcohol benzene first
1 part of acid esters, -20 1 parts of PPG-5 ceteths, 3 parts of Cremophor RH40,1 part of polysorbate -20, laruyl alcohol gathers
- 36 parts of ether, 0.5 part of card ripple, 0.5 part of nertralizer, 0.1 part of essence, deionized water surplus；The total amount of the aqueous based systems formed is
100 parts.
For the skin repair composition after bite by mosquitos and containing described in the present embodiment be used for bite by mosquitos after skin
The preparation method of the aqueous based systems of skin maintenance composition：Each raw material is conventionally well mixed, can obtain clear
Solution.
Embodiment 5
The present embodiment provides a kind of skin repair composition being used for after bite by mosquitos, and the water containing this kind of composition
Matrix system.
It is made up of for the skin repair composition after bite by mosquitos each component of following parts by weight：0.1 part of menthol, gold
10 parts of honeysuckle flower extract, 0.05 part of both A. absinthium extract, 4 parts of phragmites communis extract, 6 parts of tuckahoe extracts, dipotassium glycyrrhizinate 20
Part.
Containing the aqueous based systems described in the present embodiment for the skin repair composition after bite by mosquitos by following parts by weight
Each component form：For 40.15 parts of skin repair composition after bite by mosquitos, 10 parts of 1,3-BDO, C12-15 alcohol benzene
1 part of formic acid esters, -20 1 parts of PPG-5 ceteths, 0.05 part of PEG-6 caprylic/caprics glyceride, PEG-60 almond glyceride
0.15 part of class, 0.1 part of laureth -4,0.2 part of pH buffer, deionized water surplus；The total amount of the aqueous based systems formed
For 100 parts.
For the skin repair composition after bite by mosquitos and containing described in the present embodiment be used for bite by mosquitos after skin
The preparation method of the aqueous based systems of skin maintenance composition：Each raw material is conventionally well mixed, can obtain clear
Solution.
Embodiment 6
The present embodiment provides a kind of skin repair composition being used for after bite by mosquitos, and the water containing this kind of composition
Matrix system.
It is made up of for the skin repair composition after bite by mosquitos each component of following parts by weight：2 parts of menthol, gold and silver
0.05 part of flower extract, 0.1 part of both A. absinthium extract, 10 parts of phragmites communis extract, 0.2 part of tuckahoe extracts, glycyrrhizic acid hypo acid
1.0 part.
Containing the aqueous based systems described in the present embodiment for the skin repair composition after bite by mosquitos by following parts by weight
Each component form：For 13.35 parts of skin repair composition after bite by mosquitos, 40 parts of 1,3-BDO, C12-15 alcohol benzene
1 part of formic acid esters, 2 parts of oleth -3,2 parts of polysorbate -20,8 parts of Cremophor RH40,0.3 part of pH buffer,
Deionized water surplus；The total amount of the aqueous based systems formed is 100 parts.
For the skin repair composition after bite by mosquitos and containing described in the present embodiment be used for bite by mosquitos after skin
The preparation method of the aqueous based systems of skin maintenance composition：Each raw material is conventionally well mixed, can obtain clear
Solution.
Embodiment 7
The present embodiment provides a kind of skin repair composition being used for after bite by mosquitos, and the water containing this kind of composition
Matrix system.
It is made up of for the skin repair composition after bite by mosquitos each component of following parts by weight：0.2 part of menthol, gold
1.8 parts of honeysuckle flower extract, 18 parts of both A. absinthium extract, 10 parts of phragmites communis extract, 10 parts of tuckahoe extracts, dipotassium glycyrrhizinate 10
Part.
Containing the aqueous based systems described in the present embodiment for the skin repair composition after bite by mosquitos by following parts by weight
Each component form：For 50 parts of skin repair composition after bite by mosquitos, 10 parts of 1,3-BDO, polysorbate -20
0.2 part, 0.4 part of Cremophor RH40,0.3 part of laureth -3,0.4 part of pH buffer, deionized water surplus；Institute
The total amount of the aqueous based systems of formation is 100 parts.
For the skin repair composition after bite by mosquitos and containing described in the present embodiment be used for bite by mosquitos after skin
The preparation method of the aqueous based systems of skin maintenance composition：Each raw material is conventionally well mixed, can obtain clear
Solution.
Comparative example 1
Commercially available antipruritic liquid, declares bite by mosquitos of releiving, and containing menthol, is not added with alcohol.
Comparative example 2
Commercially available antipruritus toilet water, declares Quick itch stopping, containing menthol, spirituosity.
Comparative example 3
The present embodiment provides a kind of skin repair composition being used for after bite by mosquitos, and the water containing this kind of composition
Matrix system.
It is made up of for the skin repair composition after bite by mosquitos each component of following parts by weight：0.5 part of menthol, gold
0.5 part of honeysuckle flower extract, 0.3 part of both A. absinthium extract, 1.5 parts of phragmites communis extract, 2 parts of tuckahoe extracts, dipotassium glycyrrhizinate
0.5 part.
Containing the aqueous based systems described in the present embodiment for the skin repair composition after bite by mosquitos by following parts by weight
Each component form：For 5.3 parts of skin repair composition after bite by mosquitos, 20 parts of 1,3-BDO, PEG-40 hydrogenation castors
1.2 parts of sesame oil, 0.3 part of polysorbate -20,0.1 part of pH buffer, 0.01 part of essence, 0.5 part of preservative, more than deionized water
Amount；The total amount of the aqueous based systems formed is 100 parts.
For the skin repair composition after bite by mosquitos and containing described in the present embodiment be used for bite by mosquitos after skin
The preparation method of the aqueous based systems of skin maintenance composition：Each raw material is conventionally well mixed, can obtain clear
Solution.
Comparative example 4
The present embodiment provides a kind of skin repair composition being used for after bite by mosquitos, and the water containing this kind of composition
Matrix system.
It is made up of for the skin repair composition after bite by mosquitos each component of following parts by weight：0.1 part of menthol, gold
0.15 part of honeysuckle flower extract, 0.1 part of phragmites communis extract, 0.1 part of tuckahoe extracts, 0.25 part of glycyrrhizic acid.
Containing the aqueous based systems described in the present embodiment for the skin repair composition after bite by mosquitos by following parts by weight
Each component form：For 0.7 part of skin repair composition after bite by mosquitos, 5 parts of 1,3-BDO, PEG-60 hydrogenated castors
3 parts of oil, -3 3 parts of C12-13 Pareths, 0.1 part of pH buffer, 0.01 part of essence, 0.5 part of preservative, more than deionized water
Amount；The total amount of the aqueous based systems formed is 100 parts.
For the skin repair composition after bite by mosquitos and containing described in the present embodiment be used for bite by mosquitos after skin
The preparation method of the aqueous based systems of skin maintenance composition：Each raw material is conventionally well mixed, can obtain clear
Solution.
Low-temperature resistance performance test
Example 1-7 and contrast 1-4 test sample 100mL respectively, pours into transparent clean plastic bottle, is positioned over
7 days in 5 DEG C of constant refrigeration case, the cosmetic variation of test sample is observed, test result is as shown in table 1, and result proves this in table
Invention completely solves precipitation problem of the menthol in the aqueous based systems without ethanol.Comparative example 1 is containing thin as can be seen from Table 1
The marketed formulation of lotus alcohol low temperature in the presence of alcohol-free can separate out crystal, comparative example 3 relative to embodiment 1-7 lack cosolvent into
Point, comparative example 3 can separate out crystallization at low temperature as can be seen from Table 1.Comparative example 3 is a simple example, of the invention
Disclosed co-solvent component is for the skin repair composition of the present invention for after bite by mosquitos in water base no ethanol
Application in system is indispensable, if not adding cosolvent disclosed in this invention, the aqueous based systems being configured to are in low temperature
Under can separate out crystal.
The low-temperature resistance the performance test results of table 1
| Normal temperature sample appearance (25 DEG C) | 5 DEG C of sample appearances | |
| Embodiment 1 | Clear transparent solutions | Clear transparent solutions |
| Embodiment 2 | Clear has the mobile solution of viscosity | Clear has the mobile solution of viscosity |
| Embodiment 3 | Clear transparent solutions | Clear transparent solutions |
| Embodiment 4 | Clear gel | Clear gel |
| Embodiment 5 | Clear transparent solutions | Clear transparent solutions |
| Embodiment 6 | Clear transparent solutions | Clear transparent solutions |
| Embodiment 7 | Clear transparent solutions | Clear transparent solutions |
| Comparative example 1 | Clear transparent solutions | There is crystallization to separate out in solution |
| Comparative example 2 | Clear transparent solutions | Clear transparent solutions |
| Comparative example 3 | Clear transparent solutions | There is crystallization to separate out in solution |
| Comparative example 4 | Clear transparent solutions | Clear transparent solutions |
The antipruritic bag performance test that disappears after bite by mosquitos
This test by embodiment 1 prepare aqueous based systems exemplified by, with comparative example 1, comparative example 2, comparative example 4 water base body
System and blank control group have carried out the Contrast on effect after bite by mosquitos (without using any measure after biting).
Mosquito and tester's screening process：It is first according to the method sieve that attack is tested in GB/T 13917.9-2009
Select qualified tester and test worm, attack qualified tester had after bite by mosquitos scratchiness, skin rise bag and
It is rubescent just to carry out antipruritic test.
Antipruritic test process：The people of tester 50 (men and women half and half, age 20-45 year), is divided into 5 groups, often by tester
10 people of group, are 1 group of embodiment, 1 group of comparative example, 2 groups of comparative example, 4 groups of comparative example, blank control group respectively.Tester's the back of the hand
Expose the test zone of 4cm*4cm areas, remaining position is tightly covered, and tester puts his hand into mosquito cage to mosquito and comes to bite
10s is quickly removed afterwards, that is, is engraved in test zone and is uniformly smeared the μ L of test sample 40, and timing, record pruitus process when
Between (antipruritic time) t1, time (disappear bag time) t2 that enclosed mass disappears.
Result of the test：Statistical disposition is carried out to the experimental data of each group, is tabulated, initial data is added and subtracted with mean and marked
Quasi- difference expression, and to the significance test of difference between blank control group and other groups.Specific experiment result such as table 2.According in table
Antipruritic time t1 result understands that compared with blank control group, embodiment 1, comparative example 1, comparative example 2, comparative example 4 are respectively provided with aobvious
Sex differernce (P ＜ 0.01) is write, embodiment 1 more also has the significance difference opposite sex (P ＜ 0.01), explanation with comparative example 1, comparative example 2
Skin repair composition and aqueous based systems of the present invention for after bite by mosquitos uses the skin after bite by mosquitos
On can be very good to alleviate itch, and effect is better than commercially available prod, and embodiment 1 is different in nature with significance difference with comparative example 4 compared with
(P ＜ 0.05), the both A. absinthium extract for illustrating to remove in component can reduce antipruritic effect.According to the knot for bag time t2 that disappears in table
Fruit understands that compared with blank control group, embodiment 1, comparative example 1, comparative example 2 are respectively provided with significant difference (P ＜ 0.05), implements
Example 1 and comparative example 1, comparative example 2 more also have significance difference different in nature (P ＜ 0.01), illustrate of the present invention to sting for mosquito
For skin repair composition and aqueous based systems after stinging using can be very good to subside a swelling on the skin after bite by mosquitos, effect is good
In commercially available prod, embodiment 1 is different in nature (P ＜ 0.01) with significance difference compared with comparative example 4, and the Central Asia for illustrating to remove in component is bitter
Parthenium extract can substantially reduce the bag effect that disappears.
The antipruritic bag the performance test results that disappear after the bite by mosquitos of table 2
Malicious combability measurements are examined with human safety
This test is by taking the aqueous based systems of embodiment 4 and embodiment 7 as an example, according to cosmetics safety technical specification 2015 editions
Test acute oral toxicity, acute dermal toxicity, skin irritation, skin allergic reaction, the skin light poison of Example formulations
Property and human skin patch, concrete outcome be shown in Table 3, from table result understand embodiment formula safety, it is gentle, will not
Harmful effect is produced to skin.
3 malicious combability measurements of table and human safety assay
| Test-types | Embodiment 4 | Embodiment 7 |
| Acute oral toxicity | It is nontoxic for reality | It is nontoxic for reality |
| Skin irritation | It is nonirritant | It is nonirritant |
| Skin allergic reaction | Have no skin allergic reaction | Have no skin allergic reaction |
| Skin phototoxicity | Without phototoxicity | Without phototoxicity |
| Human skin patch | It is qualified | It is qualified |
The technology contents described above that the present invention is only further illustrated with embodiment, in order to which reader is easier to understand,
But embodiments of the present invention are not represented and are only limitted to this, any technology done according to the present invention extends or recreation, is sent out by this
Bright protection.
Claims (10)
- A kind of 1. skin repair composition being used for after bite by mosquitos, it is characterised in that each component containing following parts by weight：Menthol 0.1-2 parts；Honegsukle flower P.E 0.05-10 parts；Both A. absinthium extract 0.05-18 parts；Phragmites communis extract 0.1-10 parts；Tuckahoe extracts 0.1-10 parts；Radix glycyrrhizae class material 0.05-20 parts, the radix glycyrrhizae class material are selected from glycyrrhizic acid, glycyrrhetate, enoxolone and enoxolone At least one of salt；The Honegsukle flower P.E, both A. absinthium extract, phragmites communis extract and tuckahoe extracts are water-soluble extraction Thing.
- 2. a kind of skin repair composition being used for after bite by mosquitos according to claim 1, it is characterised in that containing following The each component of parts by weight：Menthol 0.1-2 parts；Honegsukle flower P.E 0.05-5 parts；Both A. absinthium extract 0.05-10 parts；Phragmites communis extract 1.5-4 parts；Tuckahoe extracts 3-10 parts；Radix glycyrrhizae class material 0.05-10 parts.
- A kind of 3. skin repair composition being used for after bite by mosquitos according to claim 1, it is characterised in that the peppermint Alcohol is Natural menthol and/or levorotatory menthol；The Honegsukle flower P.E is honeysuckle by low temperature water extraction and sprayed dry Dry obtained water-soluble powder；The sub- Artemisia santonica extract is that both A. absinthium is through micro- using glycerine, water and butanediol as mixed solvent Ripple extracts obtained water-soluble filtrate；The phragmites communis extract is to extract the water that reed obtains at normal temperatures using buffered aqueous solvent Dissolubility filtrate；The tuckahoe extracts are to extract the water-soluble filtrate that Poria cocos obtains at normal temperatures using buffered aqueous solvent.
- 4. a kind of contain the aqueous based systems for the skin repair composition after bite by mosquitos as claimed in claim 1, its feature It is, is made up of each component of following mass percent：For the skin repair composition 1-50% after bite by mosquitos；1,3 butylene glycol 5-40%；Solubilizer 0.2-10%；Cosolvent 0.1-7%；Surplus is water.
- 5. a kind of aqueous based systems containing for the skin repair composition after bite by mosquitos according to claim 4, it is special Sign is, is made up of each component of following mass percent：For the skin repair composition 1-30.5% after bite by mosquitos；1,3 butylene glycol 10-20%；Solubilizer 0.6-5%；Cosolvent 3-7%；Surplus is water.
- 6. a kind of aqueous based systems containing for the skin repair composition after bite by mosquitos according to claim 4, it is special Sign is that the solubilizer is selected from Cremophor RH40, PEG-60 rilanit specials, polysorbate -20, polysorbate Ester -40, Polyoxyethylene Sorbitan Monooleate, laureth -23, PPG-5 ceteths -20, oleth -20, the PEG-6 octanoic acids/last of the ten Heavenly stems Acid glycerol esters, PEG-7 glyceryl cocoates, PEG-60 passionflowers glyceride type, PEG-45 palm oil glycerides class, PEG-60 At least one of almond glyceride type.
- 7. a kind of aqueous based systems containing for the skin repair composition after bite by mosquitos according to claim 4, it is special Sign is that the cosolvent is selected from polarity grease and/or C12-18 Pareths.
- 8. a kind of aqueous based systems containing for the skin repair composition after bite by mosquitos according to claim 7, it is special Sign is that the polarity grease is selected from Permethyl 99A, isohexadecane, octyl dodecanol, C12-15 alcohol benzoic ethers, adipic acid two Ethylhexyl, ethyl oleate, isopropyl isostearate, n-nonanoic acid ethylhexyl, diethyl hexylcarbonate, the nutmeg of polypropylene glycol -3 At least one of alcohol ether, decyl oleate, benzene oxygen ethyl octanoic acid.
- 9. a kind of aqueous based systems containing for the skin repair composition after bite by mosquitos according to claim 7, it is special Sign is that the HLB value of the C12-18 Pareths is 5-9.5.
- 10. a kind of aqueous based systems containing for the skin repair composition after bite by mosquitos according to claim 7, it is special Sign is that the C12-18 Pareths are selected from laureth -2, laureth -3, laureth -4, C12-13 Pareth -2, C12-13 Pareths -3, C12-13 Pareths -4, oleth -2, oleth -3, oleyl alcohol At least one of polyethers -4, oleth -5.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111658669A (en) * | 2020-06-19 | 2020-09-15 | 北京本真工坊生物科技有限公司 | External application composition and application thereof |
| CN111686146A (en) * | 2020-06-01 | 2020-09-22 | 中国科学院合肥物质科学研究院 | Antibacterial, anti-inflammatory and antipruritic composition and preparation method thereof |
| CN111821231A (en) * | 2020-06-19 | 2020-10-27 | 广州艾蓓生物科技有限公司 | Refreshing composition and preparation method thereof |
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| CN104940075A (en) * | 2015-06-29 | 2015-09-30 | 周建志 | Floral water for preventing mosquito bites |
| CN105534871A (en) * | 2016-02-17 | 2016-05-04 | 广西大学 | Mosquito-repelling and itching-relieving floral water and preparation method thereof |
| CN105663018A (en) * | 2014-12-03 | 2016-06-15 | 玫琳凯有限公司 | Cosmetic composition |
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| CN105663018A (en) * | 2014-12-03 | 2016-06-15 | 玫琳凯有限公司 | Cosmetic composition |
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| CN111686146A (en) * | 2020-06-01 | 2020-09-22 | 中国科学院合肥物质科学研究院 | Antibacterial, anti-inflammatory and antipruritic composition and preparation method thereof |
| CN111658669A (en) * | 2020-06-19 | 2020-09-15 | 北京本真工坊生物科技有限公司 | External application composition and application thereof |
| CN111821231A (en) * | 2020-06-19 | 2020-10-27 | 广州艾蓓生物科技有限公司 | Refreshing composition and preparation method thereof |
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