CN105213652A - A kind of Chinese medicinal liniment for the treatment of skin pruritus and preparation method thereof - Google Patents

Abstract

The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicinal liniment for the treatment of skin pruritus and preparation method thereof, the raw materials of this Chinese medicinal liniment comprises: Folium Artemisiae Argyi 20-30 part, leaf of Moringa 13-17 part, Cortex Pini Massonianae 12-16 part, Pericarpium Zanthoxyli 16-20 part, Herba Portulacae 10-15 part, Fructus Kochiae 14-18 part, Herba Spirodelae 8-12 part, Radix Angelicae Dahuricae 6-14 part, Folium Mori 12-16 part, Herba Taraxaci 4-8 part and Herba Menthae 4-12 part.Medication of the present invention is suitable for, and compatibility is rigorous, makes a distinction between the important and the lesser one, mutual gain, and the pain that disappears is antipruritic.It is wide that the Chinese medicinal liniment for the treatment of skin pruritus provided by the invention has the suitability, soon effective, the course for the treatment of the shorter and advantage that cure rate is high.

Description

A kind of Chinese medicinal liniment for the treatment of skin pruritus and preparation method thereof

Technical field

The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicinal liniment for the treatment of skin pruritus and preparation method thereof.

Background technology

Skin pruritus is a kind of symptom of most of dermatosis and some systemic disease, is also one of symptom the most painful in dermatosis.Because the skin pruritus cause of disease is complicated, very itch unbearably, delay is difficult, therefore causes patient suffering unbearably.If scratch consumingly continuously, can cause affected part scratch innumerable, bloodstain is in blocks, and sepage is formed a scab, the with the passing of time coarse plumpness of illing skin, pigmentation.If secondary infection, also can cause furuncle, due to intestine erosion and ulcer etc., sickbed patients also may increase the danger of pressure ulcer, has a strong impact on healthy and quality of life, has increased the weight of the burden for the treatment of and nursing to a great extent.Different types of etiopathogenises can cause skin pruritus, as neurodermatitis, papular urticaria, chronic eczema, tinea manus and pedis, scabies, prurigo nodularis and dermatitis aestivale etc., also has fungus, acarid, own cells metabolite etc. to cause pruritus in addition.

At present, conventional external use anti pruritic medicine has Piyanping ointment, floral water, benzyl alcohol, Mentholum etc., the main component of these medicines is Mentholum and Camphora, its itching-relieving action mainly by be coated in skin makes people produce nice and cool sensory paralyses cerebral cortex realizes, but these medicines but act on not quite the pruritus that fungus, acarid, own cells metabolite etc. cause.

In the traditional Chinese medical science, the patent of invention of disclosed treatment skin pruritus has a lot at present, such as: Chinese invention patent application 201310647498.6 discloses a kind of Chinese medicine for the treatment of skin pruritus, but the part medical material cost used by the Chinese prescription of this invention is higher, the suitability is wideless, and is not very desirable to skin pruritus curative effect.

Summary of the invention

The object of the invention is to overcome weak point of the prior art, provide that a kind of suitability is wide, instant effect, short treating period, treatment skin pruritus easy to use and with low cost Chinese medicinal liniment.

Object of the present invention is achieved through the following technical solutions.

The invention provides a kind of Chinese medicinal liniment for the treatment of skin pruritus, described Chinese medicinal liniment comprises following raw materials:

Folium Artemisiae Argyi 20-30 part, leaf of Moringa 13-17 part, Cortex Pini Massonianae 12-16 part, Pericarpium Zanthoxyli 16-20 part, Herba Portulacae 10-15 part, Fructus Kochiae 14-18 part, Herba Spirodelae 8-12 part, Radix Angelicae Dahuricae 6-14 part, Folium Mori 12-16 part, Herba Taraxaci 4-8 part and Herba Menthae 4-12 part.

Further, described Chinese medicinal liniment comprises the raw materials of following parts by weight:

Folium Artemisiae Argyi 20 parts, leaf of Moringa 13 parts, Cortex Pini Massonianae 12 parts, 16 parts, Pericarpium Zanthoxyli, Herba Portulacae 10 parts, the Fructus Kochiae 14 parts, 8 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 6 parts, 12 parts, Folium Mori, Herba Taraxaci 4 parts and Herba Menthae 4 parts.

Further, described Chinese medicinal liniment comprises the raw materials of following parts by weight:

Folium Artemisiae Argyi 30 parts, leaf of Moringa 17 parts, Cortex Pini Massonianae 16 parts, 20 parts, Pericarpium Zanthoxyli, Herba Portulacae 15 parts, the Fructus Kochiae 18 parts, 12 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 14 parts, 16 parts, Folium Mori, Herba Taraxaci 8 parts and Herba Menthae 12 parts.

Further, described Chinese medicinal liniment comprises the raw materials of following parts by weight:

Folium Artemisiae Argyi 25 parts, leaf of Moringa 15 parts, Cortex Pini Massonianae 14 parts, 17 parts, Pericarpium Zanthoxyli, Herba Portulacae 13 parts, the Fructus Kochiae 16 parts, 10 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 12 parts, 14 parts, Folium Mori, Herba Taraxaci 6 parts and Herba Menthae 8 parts.

In addition, the preparation of described Chinese medicinal liniment comprises the following steps:

S1 gets leaf of Moringa, clean, crushed after being dried, cross 80-100 mesh sieve, adding medical material total amount 8-12 times amount volume fraction is the ethanol of 50-70%, add the Snailase of medical material total amount 1.5-3% again, lixiviate 1-2 hour at 38-45 DEG C, then at 85-95 DEG C of reflux, extract, 1-2 hour, filters, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtains moringa oleifera leaf extractive;

S2 gets Folium Artemisiae Argyi, Cortex Pini Massonianae, Pericarpium Zanthoxyli, Herba Portulacae, the Fructus Kochiae, Herba Spirodelae, the Radix Angelicae Dahuricae, Folium Mori, Herba Taraxaci and Herba Menthae, pulverize, mix, add the alcoholic solution reflux, extract, 2 ~ 4 times that above-mentioned coarse powder weight 4-6 times concentration is 75-85%, the time of each reflux is 1 ~ 2 hour, merge extractive liquid, filters, and leaves standstill, get supernatant, concentrating under reduced pressure becomes relative density at 65 DEG C to be 1.15 ~ 1.20 thick pastes;

The thick paste that the moringa oleifera leaf extractive that step S1 obtains by S3 and step S2 obtain mixes, and dry, pulverize, and to obtain final product.

Source, the nature and flavor of Chinese prescription of the present invention Chinese crude drug used, return through and effect:

Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort, and nature and flavor are bitter, pungent, warm; Return liver,spleen,kidney warp; Dispersing cold for relieving pain, warming the meridian for stopping bleeding.

Leaf of Moringa: the leaves being the perennial tropical deciduous tree Moringa tree of Capparales Moringaceae, strengthens immune function of human body, slow down aging, prevents disease.

Cortex Pini Massonianae: be the bark of pinaceae plant Pinus massoniana Lamb or its congener; Nature and flavor are bitter, pungent, warm; Return lung, large intestine channel; Expelling wind and removing dampness, promoting blood circulation and hemostasis, expelling pus and promoting granulation; Main rheumatic ostalgia, traumatic injury, injury by metallic tools, discharging fresh blood stool, chronic dysentery, eczema, burn and scald, carbuncle do not close up for a long time.

Pericarpium Zanthoxyli: this product is that the dry mature skin (Pericarpium Zanthoxyli) of rutaceae Capsicum annuum L. (fragrant green pepper, Zanthoxylum schinifolium, Pericarpium Zanthoxyli, Canis familiaris L. green pepper) or Pericarpium Zanthoxyli (another name for Sichuan Province green pepper, Fructus Zanthoxyli, Capsicum tetragonum, pericarpium zanthoxyli bungeani, Radix Campylotropis Hirtella (Herba Myrsines Africanae)) and seed (Semen zanthoxyli) are used as medicine; Nature and flavor are pungent, warm; Return spleen, stomach, kidney channel; Warming middle-JIAO to relieve pain, killing parasites for relieving itching.

Herba Portulacae: this product is the dry aerial parts of portulacaceous plant Herba Portulacae; Nature and flavor are sour, cold; Return liver, large intestine channel; Heat-clearing and toxic substances removing, cooling blood for hemostasis.

The Fructus Kochiae: this product is the dry mature fruit of the chenopod Fructus Kochiae; Acrid in the mouth, hardship, cold in nature; Return kidney, urinary bladder channel; Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.

Herba Spirodelae; This product is the dry herb of plant and of its applications duckweed; Nature and flavor are pungent, cold; Return lung meridian; Dispelling wind-heat, rash, diuresis.

The Radix Angelicae Dahuricae: this product is the dry root of the umbellate form section plant Radix Angelicae Dahuricae or Radix angelicae dahuricae; Nature and flavor are pungent, warm; Return stomach, large intestine, lung meridian; Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.

Folium Mori: this product is the dried leaves of moraceae plants Mulberry; Nature and flavor are sweet, bitter, cold; Return lung, Liver Channel; Dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.

Herba Taraxaci: this product is the dry herb of feverfew Herba Taraxaci; Bitter but sweet flavor, cold in nature; Return liver, stomach warp; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.

Herba Menthae: property is pungent, cool, returns lung, Liver Channel.Dispelling wind-heat, refresh oneself, rash; For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast the side of body feeling of distension and oppression.

Compared to the prior art the present invention, has following technique effect:

1, the Chinese medicinal liniment for the treatment of skin pruritus provided by the invention, plays the effect of Chinese medicine Coryza Treated by Syndrome Differentiation, and medication is suitable for, and compatibility is rigorous, makes a distinction between the important and the lesser one, wide to the suitability of skin pruritus.

2, the Chinese medicinal liniment for the treatment of skin pruritus provided by the invention is soon effective, and cure rate is high, short treating period.

3, the Chinese medicinal liniment dosage for the treatment of skin pruritus provided by the invention is few, and medical material is all listed by Chinese Pharmacopoeia, wide material sources, with low cost.

Preparation is simple for the Chinese medicinal liniment of 4, treatment skin pruritus provided by the invention, is applicable to suitability for industrialized production.

detailed description of the invention:

Below by way of the description of detailed description of the invention, the invention will be further described, but this is not limitation of the present invention, those skilled in the art are according to basic thought of the present invention, various amendment or improvement can be made, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.

embodiment 1

The embodiment of the present invention 1 Chinese medicinal liniment comprises the Chinese crude drug of following weight portion:

Folium Artemisiae Argyi 20 parts, leaf of Moringa 13 parts, Cortex Pini Massonianae 12 parts, 16 parts, Pericarpium Zanthoxyli, Herba Portulacae 10 parts, the Fructus Kochiae 14 parts, 8 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 6 parts, 12 parts, Folium Mori, Herba Taraxaci 4 parts and Herba Menthae 4 parts.

Preparation method is as follows:

S1 gets leaf of Moringa, clean, crushed after being dried, cross 80 mesh sieves, adding medical material total amount 8 times amount volume fraction is the ethanol of 50%, add the Snailase of medical material total amount 1.5% again, lixiviate 1 hour at 38 DEG C, then 85 DEG C of reflux, extract, 1 hour, filters, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10, obtains moringa oleifera leaf extractive;

S2 gets Folium Artemisiae Argyi, Cortex Pini Massonianae, Pericarpium Zanthoxyli, Herba Portulacae, the Fructus Kochiae, Herba Spirodelae, the Radix Angelicae Dahuricae, Folium Mori, Herba Taraxaci and Herba Menthae, pulverize, mix, add the alcoholic solution reflux, extract, 2 times that above-mentioned coarse powder weight 4 times of concentration are 75%, the time of each reflux is 1 hour, merge extractive liquid, filters, and leaves standstill, get supernatant, concentrating under reduced pressure becomes relative density at 65 DEG C to be 1.15 thick pastes;

The thick paste that the moringa oleifera leaf extractive that step S1 obtains by S3 and step S2 obtain mixes, and dry, pulverize, and makes liniment.

embodiment 2

The embodiment of the present invention 2 Chinese medicinal liniment comprises the Chinese crude drug of following weight portion:

Folium Artemisiae Argyi 30 parts, leaf of Moringa 17 parts, Cortex Pini Massonianae 16 parts, 20 parts, Pericarpium Zanthoxyli, Herba Portulacae 15 parts, the Fructus Kochiae 18 parts, 12 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 14 parts, 16 parts, Folium Mori, Herba Taraxaci 8 parts and Herba Menthae 12 parts.

Preparation method is as follows:

S1 gets leaf of Moringa, clean, crushed after being dried, cross 80 mesh sieves, adding medical material total amount 10 times amount volume fraction is the ethanol of 60%, add the Snailase of medical material total amount 2% again, lixiviate 1 hour at 43 DEG C, then 90 DEG C of reflux, extract, 1 hour, filters, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.20, obtains moringa oleifera leaf extractive;

S2 gets Folium Artemisiae Argyi, Cortex Pini Massonianae, Pericarpium Zanthoxyli, Herba Portulacae, the Fructus Kochiae, Herba Spirodelae, the Radix Angelicae Dahuricae, Folium Mori, Herba Taraxaci and Herba Menthae, pulverize, mix, add the alcoholic solution reflux, extract, 3 times that above-mentioned coarse powder weight 5 times of concentration are 80%, the time of each reflux is 1 hour, merge extractive liquid, filters, and leaves standstill, get supernatant, concentrating under reduced pressure becomes relative density at 65 DEG C to be 1.18 thick pastes;

The thick paste that the moringa oleifera leaf extractive that step S1 obtains by S3 and step S2 obtain mixes, and dry, pulverize, and makes liniment.

embodiment 3

The embodiment of the present invention 3 Chinese medicinal liniment comprises the Chinese crude drug of following weight portion:

Folium Artemisiae Argyi 25 parts, leaf of Moringa 15 parts, Cortex Pini Massonianae 14 parts, 17 parts, Pericarpium Zanthoxyli, Herba Portulacae 13 parts, the Fructus Kochiae 16 parts, 10 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 12 parts, 14 parts, Folium Mori, Herba Taraxaci 6 parts and Herba Menthae 8 parts.

Preparation method is as follows:

S1 gets leaf of Moringa, clean, crushed after being dried, cross 100 mesh sieves, adding medical material total amount 12 times amount volume fraction is the ethanol of 70%, add the Snailase of medical material total amount 3% again, lixiviate 2 hours at 45 DEG C, then 95 DEG C of reflux, extract, 2 hours, filters, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.25, obtains moringa oleifera leaf extractive;

S2 gets Folium Artemisiae Argyi, Cortex Pini Massonianae, Pericarpium Zanthoxyli, Herba Portulacae, the Fructus Kochiae, Herba Spirodelae, the Radix Angelicae Dahuricae, Folium Mori, Herba Taraxaci and Herba Menthae, pulverize, mix, add the alcoholic solution reflux, extract, 4 times that above-mentioned coarse powder weight 6 times of concentration are 85%, the time of each reflux is 2 hours, merge extractive liquid, filters, and leaves standstill, get supernatant, concentrating under reduced pressure becomes relative density at 65 DEG C to be 1.20 thick pastes;

The thick paste that the moringa oleifera leaf extractive that step S1 obtains by S3 and step S2 obtain mixes, and dry, pulverize, and makes liniment.

chinese medicinal liniment pharmacodynamic study of the present invention

test example one: Chinese medicinal liniment of the present invention causes the impact of guinea pig skin pruritus to histamine phosphate

1. object: according to the requirement of " new Chinese medicine pharmaceutical research guide ", study the Pharmacodynamics of Chinese medicinal liniment provided by the invention in treatment skin pruritus, the Chinese medicinal liniment of the present invention obtained for embodiment 3 being treated skin pruritus causes the Cavia porcellus administration of skin pruritus to histamine phosphate, observe Chinese medicinal liniment of the present invention to the impact of skin pruritus.

2. method: get Cavia porcellus 30, body weight 160 ~ 280g, male and female half and half, shaves hair in experiment first 1 day right back instep, is divided into 3 groups at random, often organize 10.Liniment (240mg/kg), Triamcinolone Acetonide Acetate Urea ointment (the accurate word H3402247 of traditional Chinese medicines, is produced by Anhui Xinhecheng Wannan Pharmaceutical Co., Ltd, dosage 240mg/kg) and distilled water negative control group.Precision takes histamine phosphate reference substance, and to be made into 0.01%, 0.02%, 0.03%, 0.04% a series of concentration with distilled water for subsequent use.Respectively at shaving the corresponding medicinal liquid of hair place uniform application, distilled water 1ml/kg.Next day, abrade right back instep with coarse sandpaper and shave hair place, area is about 1cm ², local repastes medicine 1 time, drips 0.01% histamine phosphate 0.05ml in last coating after 10 minutes at wound surface place, complies with 0.01%, 0.02%, 0.03%, 0.04% every 3 minutes later ... progressive concentration, is 0.05ml at every turn.Until occur Cavia porcellus later lick right back sufficient time the histamine phosphate total amount that gives be itch-threshold.Experimental result is in table 1.

the measurement result of table 1 Cavia porcellus histamine phosphate itch-threshold value

Note: ^##for comparing with model group, P<0.01.

3. conclusion

Show that itch-threshold and the model group comparing difference of liniment all have significance (P<0.01), show that liniment can significantly improve Cavia porcellus itch-threshold caused by histamine, have obvious itching-relieving action.

test two: Chinese medicinal liniment of the present invention is to the clinical observation on the therapeutic effect of the clinical volunteers patient of skin pruritus

1. physical data

Patient 100 example, man 52 example, female 48 example; In age 16-60 year, 40 years old mean age, clarify a diagnosis as skin pruritus.According to the standard that national health planning commission issues, skin pruritus screening criteria is: whole body pruritus and without obvious skin lesion, formicant itching, xerosis cutis and look asthenia, complexion white, pale tongue with thin fur the lung-pulse moistens or carefully, or flushed face, feverish sensation in the palms and soles, the dark red tongue of tongue, the few Tianjin of BOHUANG, thready and rapid pulse.

2. Therapeutic Method

Smearing the Chinese medicinal liniment that patient adopts example 1 to obtain, one day twice, continuous 7 days is a course for the treatment of.Two courses for the treatment of of continuous use and observe patients symptomatic after each course for the treatment of.

3. efficacy assessment standard

Cure, pruritus disappears, and drug withdrawal is not recurred for more than 1 year;

Effective, pruritus obviously alleviates, and the pruritus outbreak persistent period obviously shortens;

Effectively, pruritus alleviates to some extent, occasionally has gargalesthesia;

Invalid, pruritus even increases the weight of without alleviating.

4. therapeutic outcome:

Use the effect after one, two courses for the treatment of of Chinese medicinal liniment of the present invention respectively as shown in table 2 and table 3:

table 2 skin pruritus clinical volunteers uses the effect after the course for the treatment of of Chinese medicinal liniment of the present invention

table 3 skin pruritus clinical volunteers uses the effect after two courses for the treatment of of Chinese medicinal liniment of the present invention

Can draw from table 2 and table 3, Chinese medicinal liniment provided by the invention has antipruritic effect, with strong points, short treating period, can effectively treat skin pruritus symptom.

Claims (5)

1. treat a Chinese medicinal liniment for skin pruritus, it is characterized in that, described Chinese medicinal liniment comprises following raw materials:

Folium Artemisiae Argyi 20-30 part, leaf of Moringa 13-17 part, Cortex Pini Massonianae 12-16 part, Pericarpium Zanthoxyli 16-20 part, Herba Portulacae 10-15 part, Fructus Kochiae 14-18 part, Herba Spirodelae 8-12 part, Radix Angelicae Dahuricae 6-14 part, Folium Mori 12-16 part, Herba Taraxaci 4-8 part and Herba Menthae 4-12 part.

2. the Chinese medicinal liniment for the treatment of skin pruritus according to claim 1, is characterized in that, described Chinese medicinal liniment comprises the raw materials of following parts by weight:

Folium Artemisiae Argyi 20 parts, leaf of Moringa 13 parts, Cortex Pini Massonianae 12 parts, 16 parts, Pericarpium Zanthoxyli, Herba Portulacae 10 parts, the Fructus Kochiae 14 parts, 8 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 6 parts, 12 parts, Folium Mori, Herba Taraxaci 4 parts and Herba Menthae 4 parts.

3. the Chinese medicinal liniment for the treatment of skin pruritus according to claim 1, is characterized in that, described Chinese medicinal liniment comprises the raw materials of following parts by weight:

Folium Artemisiae Argyi 30 parts, leaf of Moringa 17 parts, Cortex Pini Massonianae 16 parts, 20 parts, Pericarpium Zanthoxyli, Herba Portulacae 15 parts, the Fructus Kochiae 18 parts, 12 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 14 parts, 16 parts, Folium Mori, Herba Taraxaci 8 parts and Herba Menthae 12 parts.

4. the Chinese medicinal liniment for the treatment of skin pruritus according to claim 1, is characterized in that, described Chinese medicinal liniment comprises the raw materials of following parts by weight:

Folium Artemisiae Argyi 25 parts, leaf of Moringa 15 parts, Cortex Pini Massonianae 14 parts, 17 parts, Pericarpium Zanthoxyli, Herba Portulacae 13 parts, the Fructus Kochiae 16 parts, 10 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 12 parts, 14 parts, Folium Mori, Herba Taraxaci 6 parts and Herba Menthae 8 parts.

5., according to the Chinese medicinal liniment of the arbitrary described treatment skin pruritus of claim 1-4, it is characterized in that, the preparation of described Chinese medicinal liniment comprises the following steps:

S1 gets leaf of Moringa, clean, crushed after being dried, cross 80-100 mesh sieve, adding medical material total amount 8-12 times amount volume fraction is the ethanol of 50-70%, add the Snailase of medical material total amount 1.5-3% again, lixiviate 1-2 hour at 38-45 DEG C, then at 85-95 DEG C of reflux, extract, 1-2 hour, filters, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtains moringa oleifera leaf extractive;

S2 gets Folium Artemisiae Argyi, Cortex Pini Massonianae, Pericarpium Zanthoxyli, Herba Portulacae, the Fructus Kochiae, Herba Spirodelae, the Radix Angelicae Dahuricae, Folium Mori, Herba Taraxaci and Herba Menthae, pulverize, mix, add the alcoholic solution reflux, extract, 2 ~ 4 times that above-mentioned coarse powder weight 4-6 times concentration is 75-85%, the time of each reflux is 1 ~ 2 hour, merge extractive liquid, filters, and leaves standstill, get supernatant, concentrating under reduced pressure becomes relative density at 65 DEG C to be 1.15 ~ 1.20 thick pastes;

The thick paste that the moringa oleifera leaf extractive that step S1 obtains by S3 and step S2 obtain mixes, and dry, pulverize, and to obtain final product.