CN105288126A - Chinese medicinal liniment for treating skin itch and preparing method thereof - Google Patents
Chinese medicinal liniment for treating skin itch and preparing method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine, and relates to a Chinese medicinal liniment for treating skin itch and a preparing method thereof. The Chinese medicinal liniment is prepared from radix ophiopogonis, pine bark, portulaca oleracea, borneol, duckweed, radix angelicae, snake slough and mint. The compatibility of medicines is high, medicines are matched in well graded and mutual enhancing modes, and pain and itch relieving is achieved. The Chinese medicinal liniment has the advantages of being high in applicability, capable of becoming effective quickly, short in treatment course and high in curative rate.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicinal liniment for the treatment of skin pruritus and preparation method thereof.
Background technology
Skin pruritus is one of symptom the most painful in dermatosis, because the skin pruritus cause of disease is complicated, very itches unbearably, and delay is difficult, therefore causes patient suffering unbearably.If scratch consumingly continuously, can cause affected part scratch innumerable, bloodstain is in blocks, and sepage is formed a scab, the with the passing of time coarse plumpness of illing skin, pigmentation.If secondary infection, also can cause furuncle, due to intestine erosion and ulcer etc., sickbed patients also may increase the danger of pressure ulcer, has a strong impact on healthy and quality of life, has increased the weight of the burden for the treatment of and nursing to a great extent.Different types of etiopathogenises can cause skin pruritus, as neurodermatitis, papular urticaria, chronic eczema, tinea manus and pedis, scabies, prurigo nodularis and dermatitis aestivale etc., also has fungus, acarid, own cells metabolite etc. to cause pruritus in addition.
At present, conventional external use anti pruritic medicine has Piyanping ointment, floral water, benzyl alcohol, Mentholum etc., the main component of these medicines is Mentholum and Camphora, its itching-relieving action mainly by be coated in skin makes people produce nice and cool sensory paralyses cerebral cortex realizes, but these medicines but act on not quite the pruritus that fungus, acarid, own cells metabolite etc. cause.
The patent of invention of disclosed treatment skin pruritus has a lot at present, such as: Chinese invention patent application 201310647498.6 discloses a kind of Chinese medicine composition for the treatment of skin pruritus, but the part medical material cost used by the Chinese prescription of this invention is higher, the suitability is wideless, and is not very desirable to skin pruritus curative effect.
Summary of the invention
The object of the invention is to overcome weak point of the prior art, provide that a kind of suitability is wide, instant effect, short treating period, treatment skin pruritus easy to use and with low cost Chinese medicinal liniment.
Object of the present invention is achieved through the following technical solutions.
Chinese medicinal liniment provided by the invention comprises the raw materials of following parts by weight: Radix Ophiopogonis 10-25 part, Cortex Pini Massonianae 10-20 part, Herba Portulacae 5-10 part, Borneolum Syntheticum 10-15 part, Herba Spirodelae 8-15 part, Radix Angelicae Dahuricae 8-15 part, Periostracum Serpentis 5-10 part and Herba Menthae 5-15 part.
Preferably, described Chinese medicinal liniment comprises the raw materials of following parts by weight: Radix Ophiopogonis 10 parts, Cortex Pini Massonianae 10 parts, Herba Portulacae 10 parts, Borneolum Syntheticum 10 parts, 8 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 8 parts, Periostracum Serpentis 5 parts and Herba Menthae 5 parts.
Preferably, described Chinese medicinal liniment comprises the raw materials of following parts by weight: Radix Ophiopogonis 15 parts, Cortex Pini Massonianae 15 parts, Herba Portulacae 5 parts, Borneolum Syntheticum 12 parts, 15 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 12 parts, Periostracum Serpentis 10 parts and Herba Menthae 15 parts.
Preferably, described Chinese medicinal liniment comprises the raw materials of following parts by weight: Radix Ophiopogonis 25 parts, Cortex Pini Massonianae 20 parts, Herba Portulacae 8 parts, Borneolum Syntheticum 15 parts, 12 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 15 parts, Periostracum Serpentis 8 parts and Herba Menthae 10 parts.
Correspondingly, the invention provides the preparation method of the Chinese medicinal liniment for the treatment of skin pruritus, comprise the following steps:
S1, take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 40-50% is the alcoholic solution of 60-85%, and regulation and control carbon dioxide flow is 15-20L/h, and extracting pressure is 15-20MPa, extraction temperature is 40-60 DEG C, extraction time is 1.5-2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
S2, take Cortex Pini Massonianae, Herba Portulacae, Herba Spirodelae, the Radix Angelicae Dahuricae, Periostracum Serpentis and Herba Menthae, add residue described Radix Ophiopogonis, mixing, pulverize, add the alcoholic solution reflux, extract, 2 ~ 3 times that volumetric concentration is 65 ~ 90%, the quality adding alcoholic solution is 3 ~ 5 times of mixture quality, and the time of each reflux is 1 ~ 4 hour, merge extractive liquid, filter, leave standstill, get supernatant, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.25;
S3, take Borneolum Syntheticum and add the obtained thick paste of S2, then add the alcoholic solution of 45 ~ 60%, the quality adding alcoholic solution is 1 ~ 3 times of the thick paste quality that S2 obtains, then adds described Radix Ophiopogonis extract, and mixing, obtains Chinese medicinal liniment.
Source, the nature and flavor of Chinese prescription of the present invention Chinese crude drug used, return through and effect:
Radix Ophiopogonis: be the tuber of liliaceous plant Radix Ophiopogonis, Hubei Radix Ophiopogonis, short Roripa mountain wheat or Radix Liriopes, dwarf lilyturf etc.; Sweet, micro-hardship, is slightly cold, GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, and for dryness of the lung dry cough, chronic consumptive disease is coughed, and Tianjin wound is thirsty, and vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Can immunologic function be improved, have inhibitory action to various bacteria, pituitary adrenal system function can be strengthened, improve organism adaptation ability, have arrhythmia and the peripheral vascular effect of expansion, can hypoxia-bearing capability be improved, have hypoglycemic activity.
Cortex Pini Massonianae: be the bark of pinaceae plant Pinus massoniana Lamb or its congener; Nature and flavor are bitter, pungent, warm; Return lung, large intestine channel; Expelling wind and removing dampness, promoting blood circulation and hemostasis, expelling pus and promoting granulation; Main rheumatic ostalgia, traumatic injury, injury by metallic tools, discharging fresh blood stool, chronic dysentery, eczema, burn and scald, carbuncle do not close up for a long time.
Herba Portulacae: this product is the dry aerial parts of portulacaceous plant Herba Portulacae; Nature and flavor are sour, cold; Return liver, large intestine channel; Heat-clearing and toxic substances removing, cooling blood for hemostasis.
Borneolum Syntheticum: this product is the native crystal compound of separating out in the resin for Spore density borneo camphor tree; Nature and flavor are pungent, bitter, cool; GUIXIN, lung meridian; Have one's ideas straightened out refreshment, heat radiation pain relieving, improving eyesight removing nebula.
Herba Spirodelae; This product is the dry herb of plant and of its applications duckweed; Nature and flavor are pungent, cold; Return lung meridian; Dispelling wind-heat, rash, diuresis.
The Radix Angelicae Dahuricae: this product is the dry root of the umbellate form section plant Radix Angelicae Dahuricae or Radix angelicae dahuricae; Nature and flavor are pungent, warm; Return stomach, large intestine, lung meridian; Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.
Periostracum Serpentis: this product is the dry epidermis film under Colubridae animal Elaphe taeniurus Cope, rat snake or Zaocys etc. are sloughed off; Nature and flavor are salty, sweet, flat; Return Liver Channel; Dispel the wind, calm the frightened, detoxify, nebula removing.
Herba Menthae: property is pungent, cool, returns lung, Liver Channel.Dispelling wind-heat, refresh oneself, rash; For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast the side of body feeling of distension and oppression.
Compared to the prior art the present invention, has following technique effect: 1, the Chinese medicinal liniment for the treatment of skin pruritus provided by the invention, and play the effect of Chinese medicine Coryza Treated by Syndrome Differentiation, concerted application of drugs is rigorous, makes a distinction between the important and the lesser one, wide to the suitability of skin pruritus.2, the Chinese medicinal liniment for the treatment of skin pruritus provided by the invention is soon effective, and cure rate is high, short treating period.3, the Chinese medicinal liniment dosage for the treatment of skin pruritus provided by the invention is few, and crude drug source is extensive, with low cost.Preparation is simple for the Chinese medicinal liniment of 4, treatment skin pruritus provided by the invention, is applicable to suitability for industrialized production.
detailed description of the invention:
Below by way of the description of detailed description of the invention, the invention will be further described, but this is not limitation of the present invention, those skilled in the art are according to basic thought of the present invention, various amendment or improvement can be made, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.
embodiment 1
The embodiment of the present invention 1 Chinese medicinal liniment comprises the Chinese crude drug of following weight portion: Radix Ophiopogonis 10 parts, Cortex Pini Massonianae 10 parts, Herba Portulacae 10 parts, Borneolum Syntheticum 10 parts, 8 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 8 parts, Periostracum Serpentis 5 parts and Herba Menthae 5 parts.
Preparation method is as follows:
S1, take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 45% is the alcoholic solution of 75%, and regulation and control carbon dioxide flow is 18L/h, and extracting pressure is 20MPa, extraction temperature is 50 DEG C, extraction time is 2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
S2, take Cortex Pini Massonianae, Herba Portulacae, Herba Spirodelae, the Radix Angelicae Dahuricae, Periostracum Serpentis and Herba Menthae, add residue described Radix Ophiopogonis, mixing, pulverize, add the alcoholic solution reflux, extract, 2 times that volumetric concentration is 75%, the quality adding alcoholic solution is 4 times of mixture quality, and the time of each reflux is 3 hours, merge extractive liquid, filter, leave standstill, get supernatant, being evaporated to 60 DEG C of relative densities is the thick paste of 1.20;
S3, take Borneolum Syntheticum and add the obtained thick paste of S2, then add the alcoholic solution of 50%, the quality adding alcoholic solution is 2 times of the thick paste quality that S2 obtains, then adds described Radix Ophiopogonis extract, and mixing, obtains Chinese medicinal liniment.
embodiment 2
The embodiment of the present invention 2 Chinese medicinal liniment comprises the Chinese crude drug of following weight portion: Radix Ophiopogonis 15 parts, Cortex Pini Massonianae 15 parts, Herba Portulacae 5 parts, Borneolum Syntheticum 12 parts, 15 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 12 parts, Periostracum Serpentis 10 parts and Herba Menthae 15 parts.
Preparation method is as follows:
S1, take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 50% is the alcoholic solution of 80%, and regulation and control carbon dioxide flow is 15L/h, and extracting pressure is 18MPa, extraction temperature is 40 DEG C, extraction time is 2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
S2, take Cortex Pini Massonianae, Herba Portulacae, Herba Spirodelae, the Radix Angelicae Dahuricae, Periostracum Serpentis and Herba Menthae, add residue described Radix Ophiopogonis, mixing, pulverize, add the alcoholic solution reflux, extract, 2 times that volumetric concentration is 75%, the quality adding alcoholic solution is 3 times of mixture quality, and the time of each reflux is 4 hours, merge extractive liquid, filter, leave standstill, get supernatant, being evaporated to 60 DEG C of relative densities is the thick paste of 1.25;
S3, take Borneolum Syntheticum and add the obtained thick paste of S2, then add the alcoholic solution of 60%, the quality adding alcoholic solution is 1 times of the thick paste quality that S2 obtains, then adds described Radix Ophiopogonis extract, and mixing, obtains Chinese medicinal liniment.
embodiment 3
The embodiment of the present invention 3 Chinese medicinal liniment comprises the Chinese crude drug of following weight portion: Radix Ophiopogonis 25 parts, Cortex Pini Massonianae 20 parts, Herba Portulacae 8 parts, Borneolum Syntheticum 15 parts, 12 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 15 parts, Periostracum Serpentis 8 parts and Herba Menthae 10 parts.
Preparation method is as follows:
S1, take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 40% is the alcoholic solution of 60%, and regulation and control carbon dioxide flow is 20L/h, and extracting pressure is 15MPa, extraction temperature is 60 DEG C, extraction time is 2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
S2, take Cortex Pini Massonianae, Herba Portulacae, Herba Spirodelae, the Radix Angelicae Dahuricae, Periostracum Serpentis and Herba Menthae, add residue described Radix Ophiopogonis, mixing, pulverize, add the alcoholic solution reflux, extract, 2 times that volumetric concentration is 75%, the quality adding alcoholic solution is 5 times of mixture quality, and the time of each reflux is 4 hours, merge extractive liquid, filter, leave standstill, get supernatant, being evaporated to 60 DEG C of relative densities is the thick paste of 1.30;
S3, take Borneolum Syntheticum and add the obtained thick paste of S2, then add the alcoholic solution of 60%, the quality adding alcoholic solution is 3 times of the thick paste quality that S2 obtains, then adds described Radix Ophiopogonis extract, and mixing, obtains Chinese medicinal liniment.
chinese medicinal liniment pharmacodynamic study of the present invention
test example one: Chinese medicinal liniment of the present invention causes the impact of guinea pig skin pruritus to histamine phosphate
According to the requirement of " new Chinese medicine pharmaceutical research guide ", study the Pharmacodynamics of Chinese medicinal liniment provided by the invention in treatment skin pruritus, the Chinese medicinal liniment of the present invention obtained for embodiment 1 being treated skin pruritus causes the Cavia porcellus administration of skin pruritus to histamine phosphate by basic, normal, high dosage, observe Chinese medicinal liniment of the present invention to the impact of skin pruritus.
Get Cavia porcellus 50, body weight 160 ~ 400g, male and female half and half, shave hair in experiment first 1 day right back instep, be divided into 5 groups at random, often organize 10.Dosage (120mg/kg), liniment high dose (240mg/kg), positive controls (Triamcinolone Acetonide Acetate Urea ointment, the accurate word H3402247 of traditional Chinese medicines, dosage 240mg/kg) and model group (distilled water) in liniment low dosage (60mg/kg), liniment.Precision takes histamine phosphate reference substance, and to be made into 0.01%, 0.02%, 0.03%, 0.04% a series of concentration with distilled water for subsequent use.Respectively at shaving the corresponding medicinal liquid of hair place uniform application, distilled water 1ml/kg.Next day, abrade right back instep with coarse sandpaper and shave hair place, area is about 1cm
2, local repastes medicine 1 time, drips 0.01% histamine phosphate 0.05ml in last coating after 10 minutes at wound surface place, complies with 0.01%, 0.02%, 0.03% every 3 minutes later ... progressive concentration, is 0.05ml at every turn.Until occur Cavia porcellus later lick right back sufficient time the histamine phosphate total amount that gives be itch-threshold.Experimental result is in table 1.
Note:
##for comparing with model group, P<0.01.
As known from Table 1, the itch-threshold of the basic, normal, high dosage of liniment and model group comparing difference all have significance (P<0.01), show that the basic, normal, high dosage group of liniment can significantly improve Cavia porcellus itch-threshold caused by histamine, have obvious itching-relieving action.
test two: Chinese medicinal liniment of the present invention is to the clinical observation on the therapeutic effect of the clinical volunteers patient of skin pruritus
Patient volunteer 100 example, man 52 example, female 48 example; In age 16-60 year, 39 years old mean age, clarify a diagnosis as skin pruritus.According to the standard that national health planning commission issues, skin pruritus screening criteria is: whole body pruritus and without obvious skin lesion, formicant itching, xerosis cutis and look asthenia, complexion white, pale tongue with thin fur the lung-pulse moistens or carefully, or flushed face, feverish sensation in the palms and soles, the dark red tongue of tongue, the few Tianjin of BOHUANG, thready and rapid pulse.
Therapeutic Method: smear the Chinese medicinal liniment that patient volunteer adopts example 1 to obtain, one day twice continuous 7 days is a course for the treatment of.Two courses for the treatment of of continuous use and observe patients symptomatic after each course for the treatment of.
Efficacy assessment standard: cure, pruritus disappears, and drug withdrawal is not recurred for more than 1 year; Effective, pruritus obviously alleviates, and the pruritus outbreak persistent period obviously shortens; Effectively, pruritus alleviates to some extent, occasionally has gargalesthesia; Invalid, pruritus even increases the weight of without alleviating.Use the effect after one, two courses for the treatment of of Chinese medicinal liniment of the present invention respectively as shown in table 2 and table 3:
Can draw from table 2 and table 3, Chinese medicinal liniment provided by the invention has antipruritic effect, with strong points, short treating period, can effectively treat skin pruritus symptom.
Claims (5)
1. treat the Chinese medicinal liniment of skin pruritus for one kind, it is characterized in that, described Chinese medicinal liniment comprises the raw materials of following parts by weight: Radix Ophiopogonis 10-25 part, Cortex Pini Massonianae 10-20 part, Herba Portulacae 5-10 part, Borneolum Syntheticum 10-15 part, Herba Spirodelae 8-15 part, Radix Angelicae Dahuricae 8-15 part, Periostracum Serpentis 5-10 part and Herba Menthae 5-15 part.
2. the Chinese medicinal liniment for the treatment of skin pruritus according to claim 1, it is characterized in that, described Chinese medicinal liniment comprises the raw materials of following parts by weight: Radix Ophiopogonis 10 parts, Cortex Pini Massonianae 10 parts, Herba Portulacae 10 parts, Borneolum Syntheticum 10 parts, 8 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 8 parts, Periostracum Serpentis 5 parts and Herba Menthae 5 parts.
3. the Chinese medicinal liniment for the treatment of skin pruritus according to claim 1, it is characterized in that, described Chinese medicinal liniment comprises the raw materials of following parts by weight: Radix Ophiopogonis 15 parts, Cortex Pini Massonianae 15 parts, Herba Portulacae 5 parts, Borneolum Syntheticum 12 parts, 15 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 12 parts, Periostracum Serpentis 10 parts and Herba Menthae 15 parts.
4. the Chinese medicinal liniment for the treatment of skin pruritus according to claim 1, it is characterized in that, described Chinese medicinal liniment comprises the raw materials of following parts by weight: Radix Ophiopogonis 25 parts, Cortex Pini Massonianae 20 parts, Herba Portulacae 8 parts, Borneolum Syntheticum 15 parts, 12 parts, Herba Spirodelae, the Radix Angelicae Dahuricae 15 parts, Periostracum Serpentis 8 parts and Herba Menthae 10 parts.
5., according to the preparation method of the Chinese medicinal liniment of the arbitrary described treatment skin pruritus of claim 1-4, it is characterized in that, comprise the following steps:
S1, take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 40-50% is the alcoholic solution of 60-85%, and regulation and control carbon dioxide flow is 15-20L/h, and extracting pressure is 15-20MPa, extraction temperature is 40-60 DEG C, extraction time is 1.5-2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
S2, take Cortex Pini Massonianae, Herba Portulacae, Herba Spirodelae, the Radix Angelicae Dahuricae, Periostracum Serpentis and Herba Menthae, add residue described Radix Ophiopogonis, mixing, pulverize, add the alcoholic solution reflux, extract, 2 ~ 3 times that volumetric concentration is 65 ~ 90%, the quality adding alcoholic solution is 3 ~ 5 times of mixture quality, and the time of each reflux is 1 ~ 4 hour, merge extractive liquid, filter, leave standstill, get supernatant, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.25;
S3, take Borneolum Syntheticum and add the obtained thick paste of S2, then add the alcoholic solution of 45 ~ 60%, the quality adding alcoholic solution is 1 ~ 3 times of the thick paste quality that S2 obtains, then adds described Radix Ophiopogonis extract, and mixing, obtains Chinese medicinal liniment.
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| CN103272043A (en) * | 2013-06-20 | 2013-09-04 | 哈尔滨益健堂科技开发有限公司 | Drug for treating eczema and skin itch |
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| CN103272043A (en) * | 2013-06-20 | 2013-09-04 | 哈尔滨益健堂科技开发有限公司 | Drug for treating eczema and skin itch |
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