CN102949572A - Medicinal composition for treating throat diseases, and its preparation method - Google Patents
Medicinal composition for treating throat diseases, and its preparation method Download PDFInfo
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- CN102949572A CN102949572A CN 201110242981 CN201110242981A CN102949572A CN 102949572 A CN102949572 A CN 102949572A CN 201110242981 CN201110242981 CN 201110242981 CN 201110242981 A CN201110242981 A CN 201110242981A CN 102949572 A CN102949572 A CN 102949572A
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Abstract
The invention relates to a medicinal composition for treating throat diseases, and its preparation method. The medicinal composition is developed through applying a traditional Chinese medicinal base theory, is composed of traditional Chinese medicinal raw medicines comprising Fritillaria cirrhosa, Radix Platycodonis, Rhizoma Anemarrhenae, Radix Scrophulariae, Cortex Moutan, mint, licorice and the like, has the efficacies of yin nourishing, lung heat clearing, phlegm reducing and cough relieving, can be used for treating various throat diseases, is clinically applied for many years, and has substantial curative effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, more specifically say a kind of and have nourishing YIN and clearing away lung-heat, preventing phlegm from forming and stopping coughing is used for the treatment of Chinese medicine composition of laryngopharyngeal diseases and preparation method thereof; Belong to medical technical field.
Background technology
Motherland's medical science thinks many because internal organs loss, deficiency of YIN Tianjin are few, cause by force throat discomfort on the asthenic fire, lose in moistening foster, for a long time it, drape over one's shoulders in the asthenic fire bright Tianjin of burning, and holds concurrently with depression of QI, catharsis is not smooth, and it is solidifying to cause qi depression to blood stasis expectorant.The resistance of QI and blood phlegm-turbidity and blood stasis, spacious clear YANG failing to ascend, turbid YIN failing to descend. so that QI and blood week is capable not smooth. retardance air flue and passages through which vital energy circulates.So throat occurs dry and astringent vexed swollen, such as the thing infraction, utters a sound or a word and coughs up endlessly, war proclamation setting forth the purpose of the expedition and enumerating the crimes of the enemy pain, xerostomia be the wish drink not, protracted course of disease, the pharyngolaryngeal cavity mucosa is dark red, rear wall, delete Suo Zenghou, curtain pearl hypertrophy, local vascular dilation reticulates, dimly red tongue or give birth to lean point, in addition then because of drinking and eating irregularly, surfeit is pungent, has a liking for tobacco and wine, accumulated heat in the lung and stomach.Upper steaming throat, stagnation of QI-blood, turbid the condensing of expectorant and be primary disease, controlling should regulating QI and promoting blood circulation to remove blood stasis, and YIN nourishing is supported liquid, freely throat.
Chronic pharyngitis belongs to Chinese medicine sore throat category, and this disease system is owing to be subjected to for a long time pessimal stimulation and have a liking for the pungent product of food tobacco and wine, and consumption impairing the lung kidney body fluid causes YIN fluid being insufficient, and hyperactivity of deficient fire follows through upper steaming, and the smoked throat that burns forms.Total its pathogenesis of chronic pharyngitis is YIN-deficiency of the lung and kidney, Jiu Shi and medicine of the present invention is established for this pathogenesis.Radix Scrophulariae in the side, the Rhizoma Anemarrhenae are grown the moon of lung kidney and heat clearing away, Bulbus Fritillariae Cirrhosae, the cough-relieving of Radix Platycodonis moistening the lung and resolving phlegm.Play altogether the merit of nourishing YIN and clearing away lung-heat, preventing phlegm from forming and stopping coughing.
Medicine of the present invention is the ingredients take nourishing YIN and clearing away lung-heat, preventing phlegm from forming and stopping coughing as main effect, and mainly for throat commonly used, normal smoking, the normal acute, chronic pharyngitis such as drink, the crowd of the diseases such as acute tonsillitis or pharyngolaryngitis develops.
Curative effect of medication of the present invention is good, and the adaptation population is wide, therefore is necessary to develop this class Prospect of TCM New Products.
Summary of the invention
Purpose of the present invention just provides a kind of pharmaceutical composition for the treatment of laryngopharyngeal diseases and preparation method thereof, and this pharmaceutical composition has the effect of nourishing YIN and clearing away lung-heat, preventing phlegm from forming and stopping coughing, and clinical practice is in the various laryngopharyngeal diseasess for the treatment of.This pharmaceutical composition can be prepared into different dosage form for needs of patients in addition, is convenient to take, and is easy to carry.
For achieving the above object, the pharmaceutical composition for the treatment of laryngopharyngeal diseases provided by the invention is prepared from by the processing of the crude drug of following weight parts:
Bulbus Fritillariae Cirrhosae 5-15 part Radix Platycodonis 8-15 part Rhizoma Anemarrhenae 10-20 part Radix Scrophulariae 8-15 part
Cortex Moutan 3-8 part Herba Menthae 3-8 part Radix Glycyrrhizae 5-10 part.
Preferred plan is prepared from by the processing of the crude drug of following weight parts:
12 parts of 15 portions of Radix Scrophulariaes of 10 parts of Rhizoma Anemarrhenaes of 12 parts of Radix Platycodoniss of Bulbus Fritillariae Cirrhosae
8 parts in 6 portions of Radix Glycyrrhizaes of 6 portions of Herba Menthaes of Cortex Moutan.
The pharmaceutical composition for the treatment of laryngopharyngeal diseases of the present invention can be prepared into capsule, tablet, granule.
Described weight portion can be the weight metering units such as gram, two, jin, kilogram, ton.
Pharmaceutical composition of the present invention can adopt the ingredients of conventional method in will writing out a prescription to carry out in proportion compatibility, makes various clinical applicable dosage forms by existing preparation process, and used ingredients is the Chinese crude drug that commercially available process is up to the standards.
Preparation method of the present invention comprises the steps:
(1) it is for subsequent use to get the crude drug of above-mentioned each weight portion;
(2) get Bulbus Fritillariae Cirrhosae according to the percolation (Chinese Pharmacopoeia appendix I O) under fluid extract and the extractum item, make solvent with 65～85% ethanol, flood after 18 hours, with the speed of per minute 1～3ml percolation slowly, treat that soluble component filters out fully, collect the liquid of filtering, Recycled ethanol, obtain percolate, be condensed into relative density and be 1.10～1.20 extractum;
(3) get Radix Platycodonis, the Rhizoma Anemarrhenae, Radix Scrophulariae, Radix Glycyrrhizae and add 4～6 times of water gagings and decoct 2～4 times, each 2～4 hours, filter, merging filtrate is condensed into the extractum that relative density is 1.10-1.20;
(4) get Cortex Moutan, Herba Menthae is pulverized and mixed, and adds 4-6 times of water gaging distillation 4-6 hour, collects volatile oil, preserve;
(5) with (2), (3) mixing, add appropriate amount of auxiliary materials such as the granulations such as starch, dextrin, drying sprays into the volatile oil that (4) step obtains, mixing, microwave sterilizating, granulation or filled capsules or tabletting get final product.
The preferred version of preparation method of the present invention comprises the steps:
(1) it is for subsequent use to get the crude drug of above-mentioned each weight portion;
(2) get Bulbus Fritillariae Cirrhosae according to the percolation (Chinese Pharmacopoeia appendix I O) under fluid extract and the extractum item, make solvent with 75% ethanol, flood after 18 hours, with the speed of per minute 1～3ml percolation slowly, treat that soluble component filters out fully, collect the liquid of filtering, Recycled ethanol, obtain percolate, be condensed into relative density and be 1.15 extractum;
(3) get Radix Platycodonis, the Rhizoma Anemarrhenae, Radix Scrophulariae, Radix Glycyrrhizae and add 5 times of water gagings and decoct 3 times, each 3 hours, filter, merging filtrate is condensed into relative density and is 1.15 extractum;
(4) get Cortex Moutan, Herba Menthae is pulverized and mixed, and adds 5 times of water gagings distillation 5 hours, collects volatile oil, preserve;
(5) with (2), (3) mixing, add appropriate amount of auxiliary materials such as the granulations such as starch, dextrin, drying sprays into the volatile oil that (4) step obtains, mixing, microwave sterilizating, granulation or filled capsules or tabletting get final product.
Why the present invention selects above-mentioned medical material as raw material, is because they have following effect:
Bulbus Fritillariae Cirrhosae: clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.Be used for lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.
Radix Platycodonis: lung qi dispersing, sore-throat relieving eliminates the phlegm, evacuation of pus.Be used for cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
The Rhizoma Anemarrhenae: clearing away heat-fire, promote the production of body fluid and moisturize.Be used for fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, the dryness of the intestine constipation.
Radix Scrophulariae: removing heat from blood YIN nourishing, eliminating fire and detoxication.Be used for consumption of YIN caused by febrile disease, the crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.
Cortex Moutan: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Be used for maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, the amenorrhea dysmenorrhea, carbuncle sore tumefacting virus falls and pounces on the pain of injury.
Herba Menthae: dispelling wind-heat.The refresh oneself, rash.Be used for anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast side of body feeling of distension and oppression.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Pharmaceutical composition provided by the invention has the effect of nourishing YIN and clearing away lung-heat, preventing phlegm from forming and stopping coughing, is used for the treatment of various laryngopharyngeal diseasess.
For the curative effect of medicine of the present invention is described, the applicant observes for the case aspect this in certain hospital, and the result is as follows:
Man's 15 examples, women 29 examples; Minimum 18 years old of age, maximum 61 years old; The course of disease is the longest 4 years, and is the shortest 3 months; The whole body ordinary circumstance is good, and main manifestations is pharyngeal to be done, itch, foreign body sensation, dry cough, suppress swollen, hypodynia.Hoarseness in various degree checks that pharyngeal mucosa hyperemia is kermesinus; Vasodilation, lymph foilicie hyperplasia, lateral pharyngeal band is plump, and vocal cords are congested in various degree, but movable good, have no the neoplasms such as polyp, brief summary, red tongue, the some patients were tongue is seen petechia.
Therapeutic Method: take 2 weeks of medicine of the present invention.
The result treats and cures 33 examples (75%), effective l1 example (25%), total effective rate 100% in 44 examples.
Above result shows that to alleviating disease of pharynx, the relieving cough symptom reaches the effect for the treatment of various laryngopharyngeal diseasess to medicine of the present invention by this invention medicine of above-mentioned description of test.
The excellent results of pharmaceutical composition of the present invention and preparation method thereof is:
1. medicament of the present invention is made by pure Chinese medicine, does not contain chemical components, does not contain hormone, has no side effect, and treating both the exterior and interior reaches the effect of better nourishing YIN and clearing away lung-heat, preventing phlegm from forming and stopping coughing, better treats various laryngopharyngeal diseasess;
2. this medicament can be prepared into different dosage form for needs of patients, is convenient to take, and is easy to carry;
3. technique of the present invention is simple, has reduced production cost, has alleviated patient's financial burden.
The specific embodiment
Below the present invention is treated laryngopharyngeal diseases with embodiment pharmaceutical composition and preparation method thereof be further described; this will help the present invention and effect thereof are further understood; embodiment does not limit protection scope of the present invention, and its protection domain is decided by claim.
Embodiment 1
Used crude drug is Bulbus Fritillariae Cirrhosae 150g, Radix Platycodonis 150g, Rhizoma Anemarrhenae 200g, Radix Scrophulariae 150g, Cortex Moutan 80g, Herba Menthae 80g, Radix Glycyrrhizae 100g in the present embodiment;
Its preparation method is:
Get Bulbus Fritillariae Cirrhosae according to the percolation (Chinese Pharmacopoeia appendix I O) under fluid extract and the extractum item, make solvent with 65% ethanol, flood after 18 hours, with the speed of per minute 1ml percolation slowly, treat that soluble component filters out fully, collect the liquid of filtering, Recycled ethanol, obtain percolate, be condensed into relative density and be 1.10～1.20 extractum; Other gets Radix Platycodonis, the Rhizoma Anemarrhenae, Radix Scrophulariae, Radix Glycyrrhizae and adds 6 times of water gagings and decoct 4 times, and each 4 hours, filter, merging filtrate is condensed into relative density and is 1.20 extractum; Get Cortex Moutan again, Herba Menthae is pulverized and mixed, and adds 6 times of water gagings distillation 6 hours, collects volatile oil, preserve; Merge above-mentioned two kinds of extractum, adding starch is an amount of, granulates, and drying sprays into above-mentioned volatile oil, mixing, and microwave sterilizating, granulation 400g gets final product.
Embodiment 2
Used crude drug is Bulbus Fritillariae Cirrhosae 50g, Radix Platycodonis 80g, Rhizoma Anemarrhenae 100g, Radix Scrophulariae 80g, Cortex Moutan 30g, Herba Menthae 30g, Radix Glycyrrhizae 50g in the present embodiment;
Its preparation method is:
Get Bulbus Fritillariae Cirrhosae according to the percolation (Chinese Pharmacopoeia appendix I O) under fluid extract and the extractum item, make solvent with 85% ethanol, flood after 18 hours, with the speed of per minute 3ml percolation slowly, treat that soluble component filters out fully, collect the liquid of filtering, Recycled ethanol, obtain percolate, be condensed into relative density and be 1.20 extractum; Other gets Radix Platycodonis, the Rhizoma Anemarrhenae, Radix Scrophulariae, Radix Glycyrrhizae and adds 4 times of water gagings and decoct 2 times, and each 2 hours, filter, merging filtrate is condensed into relative density and is 1.10 extractum; Get Cortex Moutan again, Herba Menthae is pulverized and mixed, and adds 4 times of water gagings distillation 4 hours, collects volatile oil, preserve; Merge above-mentioned two kinds of extractum, adding starch is an amount of, granulates, and drying sprays into above-mentioned volatile oil, mixing, and microwave sterilizating, granulation, filled capsules is made 1000, gets final product.
Embodiment 3
Used crude drug is Bulbus Fritillariae Cirrhosae 120g, Radix Platycodonis 100g, Rhizoma Anemarrhenae 150g, Radix Scrophulariae 120g, Cortex Moutan 60g, Herba Menthae 60g, Radix Glycyrrhizae 80g in the present embodiment;
Its preparation method is:
Get Bulbus Fritillariae Cirrhosae according to the percolation (Chinese Pharmacopoeia appendix I O) under fluid extract and the extractum item, make solvent with 75% ethanol, flood after 18 hours, with the speed of per minute 2ml percolation slowly, treat that soluble component filters out fully, collect the liquid of filtering, Recycled ethanol, obtain percolate, be condensed into relative density and be 1.15 extractum; Other gets Radix Platycodonis, the Rhizoma Anemarrhenae, Radix Scrophulariae, Radix Glycyrrhizae and adds 5 times of water gagings and decoct 3 times, and each 3 hours, filter, merging filtrate is condensed into relative density and is 1.15 extractum; Get Cortex Moutan again, Herba Menthae is pulverized and mixed, and adds 5 times of water gagings distillation 5 hours, collects volatile oil, preserve; Merge above-mentioned two kinds of extractum, adding starch is an amount of, granulates, and drying sprays into above-mentioned volatile oil, mixing, and microwave sterilizating, the granulation tabletting is made 1000, gets final product.
Claims (5)
1. pharmaceutical composition for the treatment of laryngopharyngeal diseases is characterized in that being prepared from by the crude drug processing of following weight parts:
Bulbus Fritillariae Cirrhosae 5-15 part Radix Platycodonis 8-15 part Rhizoma Anemarrhenae 10-20 part Radix Scrophulariae 8-15 part
Cortex Moutan 3-8 part Herba Menthae 3-8 part Radix Glycyrrhizae 5-10 part.
2. a kind of pharmaceutical composition for the treatment of laryngopharyngeal diseases according to claim 1 is characterized in that being prepared from by the crude drug processing of following weight parts:
12 parts of 15 portions of Radix Scrophulariaes of 10 parts of Rhizoma Anemarrhenaes of 12 parts of Radix Platycodoniss of Bulbus Fritillariae Cirrhosae
8 parts in 6 portions of Radix Glycyrrhizaes of 6 portions of Herba Menthaes of Cortex Moutan.
3. one of them described a kind of pharmaceutical composition for the treatment of laryngopharyngeal diseases according to claim 1 and 2 is characterized in that preparation is clinical applicable dosage form in capsule, tablet, the granule.
4. according to claim 1 or 2 one of them described a kind of preparation method for the treatment of the pharmaceutical composition of laryngopharyngeal diseases, it is characterized in that comprising the steps:
(1) it is for subsequent use to get the crude drug of above-mentioned each weight portion;
(2) get Bulbus Fritillariae Cirrhosae according to the percolation (Chinese Pharmacopoeia appendix I O) under fluid extract and the extractum item, make solvent with 65～85% ethanol, flood after 18 hours, with the speed of per minute 1～3ml percolation slowly, treat that soluble component filters out fully, collect the liquid of filtering, Recycled ethanol, obtain percolate, be condensed into relative density and be 1.10～1.20 extractum;
(3) get Radix Platycodonis, the Rhizoma Anemarrhenae, Radix Scrophulariae, Radix Glycyrrhizae and add 4～6 times of water gagings and decoct 2～4 times, each 2～4 hours, filter, merging filtrate is condensed into the extractum that relative density is 1.10-1.20;
(4) get Cortex Moutan, Herba Menthae is pulverized and mixed, and adds 4-6 times of water gaging distillation 4-6 hour, collects volatile oil, preserve;
(5) with (2), (3) mixing, add appropriate amount of auxiliary materials such as the granulations such as starch, dextrin, drying sprays into the volatile oil that (4) step obtains, mixing, microwave sterilizating, granulation or filled capsules or tabletting get final product.
5. a kind of preparation method for the treatment of the pharmaceutical composition of laryngopharyngeal diseases according to claim 4 is characterized in that comprising the steps:
(1) it is for subsequent use to get the crude drug of above-mentioned each weight portion;
(2) get Bulbus Fritillariae Cirrhosae according to the percolation (Chinese Pharmacopoeia appendix I O) under fluid extract and the extractum item, make solvent with 75% ethanol, flood after 18 hours, with the speed of per minute 1～3ml percolation slowly, treat that soluble component filters out fully, collect the liquid of filtering, Recycled ethanol, obtain percolate, be condensed into relative density and be 1.15 extractum;
(3) get Radix Platycodonis, the Rhizoma Anemarrhenae, Radix Scrophulariae, Radix Glycyrrhizae and add 5 times of water gagings and decoct 3 times, each 3 hours, filter, merging filtrate is condensed into relative density and is 1.15 extractum;
(4) get Cortex Moutan, Herba Menthae is pulverized and mixed, and adds 5 times of water gagings distillation 5 hours, collects volatile oil, preserve;
(5) with (2), (3) mixing, add appropriate amount of auxiliary materials such as the granulations such as starch, dextrin, drying sprays into the volatile oil that (4) step obtains, mixing, microwave sterilizating, granulation or filled capsules or tabletting get final product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110242981 CN102949572A (en) | 2011-08-24 | 2011-08-24 | Medicinal composition for treating throat diseases, and its preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104225370A (en) * | 2014-10-11 | 2014-12-24 | 侨健新能源科技（苏州）有限公司 | Traditional Chinese medicine for treating chronic laryngitis and enhancing immunity |
| CN104921309A (en) * | 2015-06-09 | 2015-09-23 | 柳州市智融科技有限公司 | Manufacturing method of filler for electronic cigarette |
| CN110585335A (en) * | 2019-09-30 | 2019-12-20 | 呼伦贝尔松鹿制药有限公司 | Preparation method of yin-nourishing lung-clearing oral liquid |
-
2011
- 2011-08-24 CN CN 201110242981 patent/CN102949572A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104225370A (en) * | 2014-10-11 | 2014-12-24 | 侨健新能源科技（苏州）有限公司 | Traditional Chinese medicine for treating chronic laryngitis and enhancing immunity |
| CN104921309A (en) * | 2015-06-09 | 2015-09-23 | 柳州市智融科技有限公司 | Manufacturing method of filler for electronic cigarette |
| CN110585335A (en) * | 2019-09-30 | 2019-12-20 | 呼伦贝尔松鹿制药有限公司 | Preparation method of yin-nourishing lung-clearing oral liquid |
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Application publication date: 20130306 |