CN105169296A - Traditional Chinese medicine composition for treating psoriasis - Google Patents
Traditional Chinese medicine composition for treating psoriasis Download PDFInfo
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- CN105169296A CN105169296A CN201510749052.3A CN201510749052A CN105169296A CN 105169296 A CN105169296 A CN 105169296A CN 201510749052 A CN201510749052 A CN 201510749052A CN 105169296 A CN105169296 A CN 105169296A
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Abstract
The invention provides a traditional Chinese medicine composition for treating psoriasis. The medicine composition is characterized by comprising the following components in parts by weight: 1-32 parts of Paris polyphylla Smith, 1-32 parts of rehmannia root, 1-28 parts of red paeony root, 1-28 parts of heartleaf houttuynia herb, 1-22 parts of amur corktree bark, 1-20 parts of great burdock achene, 1-20 parts of zedoray rhizome, 1-10 parts of honeysuckle flower and 1-8 parts of liquorice root. A medicine composition preparation comprises the traditional Chinese medicine composition and a pharmaceutically acceptable carrier. The dosage forms of the preparation include water decoction, pills, tablets, capsules, granules, instant granules and oral liquid. The composition has obvious curative effects on patients with psoriasis and does not have toxic or side effect.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to one and treat psoriatic Chinese medicine composition.
Background technology
Psoriasis is commonly called as psoriasis, and be commonly called as " not dead cancer ", be a kind of common skin diseases being feature with epidermal hyper-proliferative and dermal chronic inflammatory reaction, the prevalence of general population is about 2%, has the trend raised year by year.This sick sickness rate is higher, and the course of disease is longer, falls ill based on person between twenty and fifty, affects larger on the healthy of patient and mental status.Clinical manifestation is with erythema, and squama is main, and whole body all can be fallen ill, and with scalp, it is comparatively common that extremity stretch side, how to increase the weight of in the winter time.
The psoriatic medicine of current treatment is mainly: vitamin D 3-derivatives is as calcipotriol, tacalcitol; Glucocorticoid is as clobetasol propionate, halometasone; Tretinoin; Ciclosporin etc.Tazarotene, middle effect and potent glucocorticoid, calcipotriol can be used as the first-line drug of topical therapeutic.
Chinese medicine thinks that psoriasis is because of the intrinsic plain heat in blood of body, or the outer six climate exopathogens of sense, invasion and attack skin, or mind is bothered, internal injury caused by excess of seven emotions, or surfeit is pungent, eating and drinking without temperance, makes to accumulate in heat in blood, and outer heap soil or fertilizer over and around the roots skin forms.First originator is often because of intense heat bringing about wind syndrome, and wind contains dryness-transformation, for heat in blood wind is contained; The cloudy blood of person of a specified duration is hindered, and scorchingly hot most, failure of skin and muscle to be nourished is blood-deficiency and wind-dry; How hot and suffocating psoriasis is, easily formed damp and hot, holds concurrently wet or damp and hot removing toxic substances for wind heat; Or insufficiency of kidney-YANG easily presss from both sides cold, cause for rheumatism illness is stagnant etc.Utilize pharmaceutical composition clearing away heat and cooling blood of the present invention, removing toxic substances of dispeling the wind, nourishing YIN and benefiting blood are moisturized and are carried out dialectical treating, then take psychological counseling, health diet, strengthen taking exercise, and can reach effect for the treatment of both the principal and secondary aspects of a disease to psoriasis.
Summary of the invention
The present invention aims to provide one and treats psoriatic Chinese medicine composition.
For achieving the above object, one of the present invention treats psoriatic Chinese medicine composition, and its concrete scheme is:
One of the present invention treats psoriatic Chinese medicine composition, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Rhizoma Paridis 1-32 part, Radix Rehmanniae 1-32 part, Radix Paeoniae Rubra 1-28 part, Herba Houttuyniae 1-28 part, Cortex Phellodendri 1-22 part, Fructus Arctii 1-20 part, Rhizoma Curcumae 1-20 part, Flos Lonicerae 1-10 part, Radix Glycyrrhizae 1-8 part.
One of the present invention treats psoriatic Chinese medicine composition, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Rhizoma Paridis 8-25 part, Radix Rehmanniae 8-25 part, Radix Paeoniae Rubra 5-22 part, Herba Houttuyniae 5-18 part, Cortex Phellodendri 2-15 part, Fructus Arctii 2-15 part, Rhizoma Curcumae 3-16 part, Flos Lonicerae 3-8 part, Radix Glycyrrhizae 2-5 part.
One of the present invention treats psoriatic Chinese medicine composition, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Rhizoma Paridis 25 parts, Radix Rehmanniae 22 parts, Radix Paeoniae Rubra 18 parts, Herba Houttuyniae 16 parts, Cortex Phellodendri 13 parts, Fructus Arctii 13 parts, Rhizoma Curcumae 9 parts, Flos Lonicerae 7 parts, 3 parts, Radix Glycyrrhizae.
The preparation of Chinese medicine composition of the present invention, is characterized in that, described preparation is oral formulations.
Preparation of the present invention, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, tablet, capsule, granule, electuary and oral liquid.
Preparation of the present invention, is characterized in that, described preparation is capsule.
Preparation of the present invention, is characterized in that, the preparation method of described capsule is:
1) get recipe quantity Rhizoma Paridis, Radix Rehmanniae, Radix Paeoniae Rubra, Herba Houttuyniae, Cortex Phellodendri, Fructus Arctii, Rhizoma Curcumae, Flos Lonicerae, Radix Glycyrrhizae, mixing, dry, grind;
2) water extraction twice, first time adds 6-12 times amount water extraction 1-3h, and filter, medicinal residues add 5-8 times amount water extraction 0.5-3h again, filters, merges twice filtrate.Be evaporated to relative density 1.20 ~ 1.50, obtain Aqueous extracts thick paste;
3) add the adjuvant of proper proportion in thick paste, stir, obtained soft material;
4) cross 10 mesh sieves, obtain wet granular;
5) 50 ~ 60 DEG C of dryings, cross 10 mesh sieves and 65 mesh sieve granulate after dry granule cooling respectively, encapsulated, to obtain final product.Preparation of the present invention, is characterized in that, the adjuvant of preparing of described capsule is: one or more combinations in sucrose, lactose, mannitol, aspartame, stevioside, dextrin, soluble starch, sodium carboxymethyl cellulose, polyvidone.
The application of Chinese medicine composition of the present invention in preparation treatment psoriasis.
The each component pharmacology analysis of prescription of the present invention:
Rhizoma Paridis: bitter, cool; Mild toxicity, GUIXIN warp, Liver Channel, lung meridian, stomach warp, large intestine channel.Function: anticancer, the reducing swelling and alleviating pain of relieving internal heat, heat clearing away arresting convulsion, antitussive and antiasthmatic.
Radix Rehmanniae: clearing away heat and promoting production of body fluid, after cool, hemostasis; For hot blast impairment of YIN, crimson tongue excessive thirst, send out speckle dermexanthesis, haematemesis, epistaxis, laryngopharynx swelling and pain.Radix Rehmanniae clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.
Radix Paeoniae Rubra: bitter in the mouth, cold nature, returns Liver Channel; There is clearing away heat and cooling blood, effect of blood circulation promoting and blood stasis dispelling.
Herba Houttuyniae: acrid in the mouth, cold, return lung meridian; Heat-clearing and toxic substances removing, detumescence can treat skin ulcer, promoting urination to remove dampness, clearing away heat to cure dysentery, invigorating the stomach and promoting digestion, by the lung abscess, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc. of controlling excess-heat, pyretic toxicity, damp, disease heat are trouble.
Cortex Phellodendri: bitter in the mouth, cold in nature.Return kidney, urinary bladder channel; Have heat clearing and damp drying, pathogenic fire purging removes steams, effect of detoxification sore treatment.
Fructus Arctii: there is dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, effect of removing toxic substances and promoting subsidence of swelling.
Rhizoma Curcumae: pungent, bitter, temperature; Return liver, spleen channel, removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.
Flos Lonicerae: dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, send out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal Be very effective.
Radix Glycyrrhizae: feeble QI, taste is sweet and special; Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.
Chinese medicine thinks that psoriasis is because of the intrinsic plain heat in blood of body, or the outer six climate exopathogens of sense, invasion and attack skin, or mind is bothered, internal injury caused by excess of seven emotions, or surfeit is pungent, eating and drinking without temperance, makes to accumulate in heat in blood, and outer heap soil or fertilizer over and around the roots skin forms.First originator is often because of intense heat bringing about wind syndrome, and wind contains dryness-transformation, for heat in blood wind is contained; The cloudy blood of person of a specified duration is hindered, and scorchingly hot most, failure of skin and muscle to be nourished is blood-deficiency and wind-dry; How hot and suffocating psoriasis is, easily formed damp and hot, holds concurrently wet or damp and hot removing toxic substances for wind heat; Or insufficiency of kidney-YANG easily presss from both sides cold, cause for rheumatism illness is stagnant etc.
Wherein, Rhizoma Paridis in side, Radix Rehmanniae has clearing away heat and cooling blood, yin nourishing, the merit of promoting the production of body fluid, and is monarch drug.Radix Paeoniae Rubra, Herba Houttuyniae, Cortex Phellodendri, Fructus Arctii is the ministerial drug of this compositions, and heat-clearing and toxic substances removing, detumescence treat skin ulcer; Rhizoma Curcumae, Flos Lonicerae dispelling wind-heat, removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving is the adjuvant drug of this compositions; We are based on the product of YIN nourishing and the production of body fluid promoting, clearing away heat and cooling blood, and be aided with hard masses softening and resolving, inducing diuresis to remove edema, soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant, removing blood stasis circulation of qi promoting, the medicine of removing food stagnancy pain relieving.
Pharmaceutical composition clearing away heat and cooling blood of the present invention, removing toxic substances of dispeling the wind, nourishing YIN and benefiting blood are moisturized and are carried out dialectical treating, then take psychological counseling, health diet, strengthen taking exercise, and can reach effect for the treatment of both the principal and secondary aspects of a disease to psoriasis.
Detailed description of the invention
Embodiment is only for further illustrating the present invention below, does not limit the scope of the invention in any form.
Embodiment 1
Present composition decoction prescription and preparation method: get Rhizoma Paridis 25 parts, Radix Rehmanniae 22 parts, Radix Paeoniae Rubra 18 parts, Herba Houttuyniae 16 parts, Cortex Phellodendri 13 parts, Fructus Arctii 13 parts, Rhizoma Curcumae 9 parts, Flos Lonicerae 7 parts, 3 parts, Radix Glycyrrhizae.Dry, grind; Crude drug is added the water of 10 times of quality, decoct 2 hours, filter; Medicinal residues add the water of 5 times of quality again, decoct 40 minutes, filter; Merge twice filtrate, to obtain final product.
Embodiment 2
Present composition capsule prescription and preparation method: Rhizoma Paridis 25 parts, Radix Rehmanniae 22 parts, Radix Paeoniae Rubra 18 parts, Herba Houttuyniae 16 parts, Cortex Phellodendri 13 parts, Fructus Arctii 13 parts, Rhizoma Curcumae 9 parts, Flos Lonicerae 7 parts, 3 parts, Radix Glycyrrhizae.Dry, grind, water extraction twice, first time adds 10 times amount water extraction 2h, and filter, medicinal residues add 5 times amount water extraction 40min again, filters, merges twice filtrate.Be evaporated to relative density 1.20 ~ 1.50, obtain Aqueous extracts thick paste; Add the mannitol of proper proportion, soluble starch, sodium carboxymethyl cellulose, polyvidone in thick paste, stir, soft material processed; Cross 10 mesh sieves, obtain wet granular; 50 ~ 60 DEG C of dryings, cross 10 mesh sieves and 65 mesh sieve granulate after dry granule cooling respectively, encapsulated, to obtain final product.
Embodiment 3
Present composition tablet formulation and preparation method: get Rhizoma Paridis 25 parts, Radix Rehmanniae 22 parts, Radix Paeoniae Rubra 18 parts, Herba Houttuyniae 16 parts, Cortex Phellodendri 13 parts, Fructus Arctii 13 parts, Rhizoma Curcumae 9 parts, Flos Lonicerae 7 parts, 3 parts, Radix Glycyrrhizae.Dry, grind, water extraction twice, first time adds 12 times amount water extraction 2h, and filter, medicinal residues add 8 times amount water extraction 1h again, filters, merges twice filtrate.Be evaporated to relative density 1.20 ~ 1.50, obtain Aqueous extracts thick paste; Add the mannitol of proper proportion, soluble starch, sodium carboxymethyl cellulose, polyvidone in thick paste, stir, obtained soft material; Cross 24 mesh sieves, obtain wet granular.50 ~ 60 DEG C of dryings, cross 60 mesh sieve granulate respectively after dry granule cooling, additional micropowder silica gel, tabletting, to obtain final product.
Embodiment 4
Present composition electuary prescription and preparation method: Rhizoma Paridis 25 parts, Radix Rehmanniae 22 parts, Radix Paeoniae Rubra 18 parts, Herba Houttuyniae 16 parts, Cortex Phellodendri 13 parts, Fructus Arctii 13 parts, Rhizoma Curcumae 9 parts, Flos Lonicerae 7 parts, 3 parts, Radix Glycyrrhizae.Mixing, dries, grinds.Water extraction twice, first time adds 8 times amount water extraction 2h, and filter, medicinal residues add 6 times amount water extraction 30min again, filters, merges twice filtrate.Be evaporated to relative density 1.20 ~ 1.30, obtain Aqueous extracts thick paste.Add the mannitol of proper proportion in thick paste, pre-paying starch, sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose stir, obtained soft material.Crushed 10 mesh sieves, obtain wet granular.50 ~ 60 DEG C of dryings, cross 10 mesh sieves and 65 mesh sieve granulate respectively after dry granule cooling, make powder or graininess electuary.
Embodiment 5
Pharmacodynamics test:
Adopt 5% propranolol hydrochloride emulsion-type liniment to smear Cavia porcellus both sides skin of pinna continuously, carry out the modeling of silver bits sample skin lesion, occur that the symptom such as hyperkeratosis, parakeratosis is for modeling success with Cavia porcellus ear keratinocyte hyperplasia.Adopt ELISA kit, detect tumor necrosis factor-alpha (TNF-α) in ear tissue, the content of ICAM (ICAM-1), the results are shown in Table 1.
Table 1 difference group medicine affects the content of TNF-α, ICAM-1 in ear tissue
Result shows, the present invention can reduce the content of TNF-α and ICAM-1 significantly, has good therapeutical effect to psoriasis, and therapeutic effect is suitable with methotrexate.
Claims (9)
1. treat a psoriatic Chinese medicine composition, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Rhizoma Paridis 1-32 part, Radix Rehmanniae 1-32 part, Radix Paeoniae Rubra 1-28 part, Herba Houttuyniae 1-28 part, Cortex Phellodendri 1-22 part, Fructus Arctii 1-20 part, Rhizoma Curcumae 1-20 part, Flos Lonicerae 1-10 part, Radix Glycyrrhizae 1-8 part.
2. one treats psoriatic Chinese medicine composition according to claim 1, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Rhizoma Paridis 8-25 part, Radix Rehmanniae 8-25 part, Radix Paeoniae Rubra 5-22 part, Herba Houttuyniae 5-18 part, Cortex Phellodendri 2-15 part, Fructus Arctii 2-15 part, Rhizoma Curcumae 3-16 part, Flos Lonicerae 3-8 part, Radix Glycyrrhizae 2-5 part.
3. one treats psoriatic Chinese medicine composition according to claim 1, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Rhizoma Paridis 25 parts, Radix Rehmanniae 22 parts, Radix Paeoniae Rubra 18 parts, Herba Houttuyniae 16 parts, Cortex Phellodendri 13 parts, Fructus Arctii 13 parts, Rhizoma Curcumae 9 parts, Flos Lonicerae 7 parts, 3 parts, Radix Glycyrrhizae.
4. the preparation of the Chinese medicine composition according to any one of claim 1-3, is characterized in that, described preparation is oral formulations.
5. preparation according to claim 4, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, tablet, capsule, granule, electuary and oral liquid.
6. preparation according to claim 5, is characterized in that, described preparation is capsule.
7. preparation according to claim 6, is characterized in that, the preparation method of described capsule is:
1) get recipe quantity Rhizoma Paridis, Radix Rehmanniae, Radix Paeoniae Rubra, Herba Houttuyniae, Cortex Phellodendri, Fructus Arctii, Rhizoma Curcumae, Flos Lonicerae, Radix Glycyrrhizae, mixing, dry, grind;
2) water extraction twice, first time adds 6-12 times amount water extraction 1-3h, and filter, medicinal residues add 5-8 times amount water extraction 0.5-3h again, filters, merges twice filtrate; Be evaporated to relative density 1.20 ~ 1.50, obtain Aqueous extracts thick paste;
3) add the adjuvant of proper proportion in thick paste, stir, obtained soft material;
4) cross 10 mesh sieves, obtain wet granular;
5) 50 ~ 60 DEG C of dryings, cross 10 mesh sieves and 65 mesh sieve granulate after dry granule cooling respectively, encapsulated, to obtain final product.
8. the adjuvant of preparing of capsule is according to claim 7: one or more combinations in sucrose, lactose, mannitol, aspartame, stevioside, dextrin, soluble starch, sodium carboxymethyl cellulose, polyvidone.
9. the application of the Chinese medicine composition described in any one of claim 1-3 in preparation treatment psoriasis.
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| CN201510749052.3A CN105169296A (en) | 2015-11-08 | 2015-11-08 | Traditional Chinese medicine composition for treating psoriasis |
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| CN201510749052.3A CN105169296A (en) | 2015-11-08 | 2015-11-08 | Traditional Chinese medicine composition for treating psoriasis |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1077896A (en) * | 1993-03-11 | 1993-11-03 | 曲贵民 | Medicine for psoriasis and manufacture method |
| CN101897868A (en) * | 2010-06-28 | 2010-12-01 | 赵子山 | Chinese medicinal composition for treating psoriasis and preparation method thereof |
| CN103381246A (en) * | 2013-04-25 | 2013-11-06 | 苏州谷力生物科技有限公司 | Traditional Chinese medicine for treating psoriasis |
| CN103656369A (en) * | 2012-09-18 | 2014-03-26 | 青岛医防消毒专业技术中心 | Compound medicine for preventing and treating psoriasis |
| CN103705722A (en) * | 2012-10-09 | 2014-04-09 | 仇美秋 | Formula of drug for treating psoriasis |
-
2015
- 2015-11-08 CN CN201510749052.3A patent/CN105169296A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1077896A (en) * | 1993-03-11 | 1993-11-03 | 曲贵民 | Medicine for psoriasis and manufacture method |
| CN101897868A (en) * | 2010-06-28 | 2010-12-01 | 赵子山 | Chinese medicinal composition for treating psoriasis and preparation method thereof |
| CN103656369A (en) * | 2012-09-18 | 2014-03-26 | 青岛医防消毒专业技术中心 | Compound medicine for preventing and treating psoriasis |
| CN103705722A (en) * | 2012-10-09 | 2014-04-09 | 仇美秋 | Formula of drug for treating psoriasis |
| CN103381246A (en) * | 2013-04-25 | 2013-11-06 | 苏州谷力生物科技有限公司 | Traditional Chinese medicine for treating psoriasis |
Non-Patent Citations (1)
| Title |
|---|
| 石志发: "中医药治疗银屑168例疗效观察", 《内蒙古中医药》 * |
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Application publication date: 20151223 |
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