CN104971115A - Liniment for treating scabies and preparation method thereof - Google Patents
Liniment for treating scabies and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a liniment for treating scabies. The liniment is mainly prepared from the following medicinal raw materials in parts by mass: 9-16 parts of semen boitae, 11-15 parts of sweetviburnum stem, 8-13 parts of thick-fruited millettia seed, 10-14 parts of lawn pennywort herb, 9-16 parts of euphorbia tithymaloides, 11-17 parts of sophora davidii leaf, 7-16 parts of cleistocalyx operculatus cortex, 10-16 parts of centella, 8-12 parts of cortex dictamni, 7-15 parts of fructus cnidii, 13-18 parts of lonicera japonica, 10-17 parts of patrinia, 8-14 parts of coralhead plant seed, 6-15 parts of upborne elixir residue, 9-13 parts of siberian elm bark and 7-14 parts of storax. The liniment is prepared by years of clinical practice, has the effects of killing parasites to relieve itching, diminishing swelling and healing sore, and has remarkable curative effects.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of liniment and method for making for the treatment of scabies.
Background technology
Mange and scab is the parasitogenic dermatitis due to scabies acarid.The scabies and the tinea that parasitize human body are all more common dermatosiss.Scabies is the most common mainly with finger seam, is also common in the institutes such as the fossa cubitalis, oxter, lower abdomen, groin, buttocks and leg, very then throughout whole body.Present pinhead-sized pimple and vesicle, itch very, therefore the common scratch of body surface and incrustation.Have after grabbing and grow water person, be called eczema; Without growing water person, be called dry scabies; The infection suppurates person because scratching broken skin skin, is called " scabies complicated by pyogenic infection ".Primary disease many because of rheumatism pathogenic heat strongly fragrant in skin, contagion, sarcoptic mite hides caused by skin.The tinea traditional Chinese medical science also has many dividing.According to the position of disease damage, send out season well, send out the age well, clinical disease damage feature is different, has many different titles.Its feature, all with erythra white scales, infiltrates plump, local pruritus, and it is hemorrhage etc. very then to scrape broken skin.Its cause of disease is many because of blood-deficiency and wind-dry, and battalion defends imbalance, outward by ailment said due to cold or exposure, caused by failure of skin and muscle to be nourished.
Publication No. CN 102716391 A(application number 201210198110.4) Chinese patent literature disclose a kind of pharmaceutical composition for the treatment of skin pruritus, the crude drug of said composition consists of: Pien Tze Huang powder 15 ~ 40 weight portion, Radix Rehmanniae 65 ~ 155 weight portion, the Radix Astragali 30 ~ 70 weight portion, Rhizoma Smilacis Glabrae 65 ~ 155 weight portion, Cortex Dictamni 30 ~ 70 weight portion, Radix Angelicae Sinensis 30 ~ 70 weight portion, Herba Xanthii grass 60 ~ 100 weight portion, Flos Chrysanthemi Indici 60 ~ 100 weight portion, Agkistrodon 15 ~ 40 weight portion processed, Fructus Tribuli 65 ~ 155 weight portion, Radix Salviae Miltiorrhizae 60 ~ 100 weight portion, Radix Paeoniae Rubra 30 ~ 70 weight portion, Radix Sophorae Flavescentis 60 ~ 100 weight portion, Semen Ziziphi Spinosae (parched) 30 ~ 70 weight portion, Radix Glycyrrhizae 20 ~ 50 weight portion.Publication No. CN 104546973A(application number 201310517891.3) Chinese patent literature disclose a kind of heat clearing away antifungal Chinese medicine formula, formulated by Galla Chinensis, dried Alumen, Cortex Pseudolaricis, Mylabris, Realgar, Herba Solidaginis and mature vinegar; By mass, Galla Chinensis 5 ~ 15g, dried Alumen 5 ~ 15g, Cortex Pseudolaricis 15 ~ 25g, Mylabris 10 ~ 20g, Realgar 10 ~ 14g, Herba Solidaginis 8 ~ 12g, be positioned over 250ml mature vinegar by Galla Chinensis, dried Alumen, Cortex Pseudolaricis, Mylabris, Realgar, Herba Solidaginis, brewed 7 days.Publication No. CN 104147188 A(application number 201410330687.5) Chinese patent literature disclose a kind of skin infection scabies wine and using method thereof, this skin infection scabies wine comprises edible distillate spirit, soaks the Radix Angelicae Dahuricae, Cortex Dictamni, Radix Scutellariae, Rhizoma Coptidis, Flos Lonicerae and Herba seu radix metaplexis in described Chinese liquor.
The medicine of current treatment scabies can only play the effect of mitigate the disease, long-term prescription mostly, affects patient body healthy, therefore needs to develop a kind of medicine of evident in efficacy, treating both the principal and secondary aspects of a disease, can thoroughly cure this disease.
Summary of the invention
For the problem of prior art, the object of this invention is to provide liniment and the method for making of the wide treatment scabies of a kind of Be very effective, the use safety suitability.
Technical scheme of the present invention is:
Treat a liniment for scabies, be prepared from primarily of following bulk drugs, be mass parts: Semen Platycladi 9-16; Caulis Viburni Macrocephali 11-15; Semen Seu Fructus Millettiae Pachycarpae 8-13; Herba Hydrocotyles 10-14; Distortion grass 9-16; Folium Sophorae viciifoliae 11-17; Cortex Cleistocalycis Operculati 7-16; Herba Centellae 10-16; Cortex Dictamni 8-12; Fructus Cnidii 7-15; Flos Lonicerae 13-18; Herba Patriniae 10-17; Semen Abri Precatorii 8-14; Hydrargyrum Oxydatum Crudum Bottom 6-15; Cortex ulmi pumilae 9-13; Styrax 7-14.
Preferred version is, Semen Platycladi 11-14; Caulis Viburni Macrocephali 12-14; Semen Seu Fructus Millettiae Pachycarpae 9-12; Herba Hydrocotyles 11-13; Distortion grass 11-14; Folium Sophorae viciifoliae 13-15; Cortex Cleistocalycis Operculati 9-14; Herba Centellae 12-14; Cortex Dictamni 9-11; Fructus Cnidii 9-13; Flos Lonicerae 14-17; Herba Patriniae 12-15; Semen Abri Precatorii 10-12; Hydrargyrum Oxydatum Crudum Bottom 8-13; Cortex ulmi pumilae 10-12; Styrax 9-12.
More preferably, Semen Platycladi 12.5; Caulis Viburni Macrocephali 13; Semen Seu Fructus Millettiae Pachycarpae 10.5; Herba Hydrocotyles 12; Distortion grass 12.5; Folium Sophorae viciifoliae 14; Cortex Cleistocalycis Operculati 11.5; Herba Centellae 13; Cortex Dictamni 10; Fructus Cnidii 11; Flos Lonicerae 15.5; Herba Patriniae 13.5; Semen Abri Precatorii 11; Hydrargyrum Oxydatum Crudum Bottom 10.5; Cortex ulmi pumilae 11; Styrax 10.5.
Described a kind of preparation method for the treatment of the liniment of scabies, step is as follows:
(1) get Semen Platycladi, Semen Seu Fructus Millettiae Pachycarpae, Fructus Cnidii and Semen Abri Precatorii remove impurity to clean, add clean sandy soil and mix thoroughly, be placed in frying pan, moderate heat stir-fry 8-16 minute (preferred: moderate heat stir-fries 10-14 minute; Be more preferably: moderate heat stir-fries 12 minutes), take out, eliminate sandy soil;
(2) get Cortex Cleistocalycis Operculati, Cortex Dictamni and Cortex ulmi pumilae removing impurity, be cut into thread, mix with Testa Tritici (mass ratio of Testa Tritici and crude drug is 1:8), add rice vinegar and mix moistening 12-24 minute thoroughly (preferably: add rice vinegar and mix moistening 16-20 minute thoroughly; Be more preferably: add rice vinegar and mix moistening thoroughly 18 minutes), be placed in frying pan, moderate heat stir-fries to having and smolders, and takes out, and sieve removes Testa Tritici, cools, pulverizes and sieves together with step (1) made crude drug;
(3) cleaned by Styrax, put into container, heating in water bath, to melting, filters, and removing impurity, adds Chinese liquor, be placed in electrothermostat, 115 DEG C heated at constant temperature 10-20 minute (preferred: heated at constant temperature 12-18 minute; Be more preferably: heated at constant temperature 15 minutes), take out;
(4) Caulis Viburni Macrocephali, Herba Hydrocotyles, distortion grass, Folium Sophorae viciifoliae, Herba Centellae, Flos Lonicerae, Herba Patriniae and Hydrargyrum Oxydatum Crudum Bottom are cleaned remove impurity, be placed in steamer, add vinegar water and steam 14-28 minute (preferably: add vinegar water and steam 18-24 minute; Be more preferably: add vinegar water and steam 21 minutes), take out chopping, mix, be placed in container with step (2) gained medicated powder, the ethanol adding 75% leaves standstill 15 minutes, and reflux, extract, three times, merges three gained extracting solution, and reclaims ethanol extremely without alcohol taste;
(5) by step (3) (4) made crude drug and extracting solution mixing, add adjuvant mix homogeneously, encapsulate and obtain liniment.
Described a kind of preparation method for the treatment of the liniment of scabies, it is that the 0.2-0.5 of crude drug quality is doubly (preferred: to add 0.3-0.4 times that rice vinegar amount is crude drug quality that step (2) adds rice vinegar amount; Be more preferably: add 0.35 times that rice vinegar amount is crude drug quality).
Described a kind of preparation method for the treatment of the liniment of scabies, it is (preferred: to pulverize 100-120 mesh sieve that step (2) pulverized 80-140 mesh sieve; Be more preferably: pulverized 110 mesh sieves).
Described a kind of preparation method for the treatment of the liniment of scabies, it is the 1-3 of Styrax quality doubly (preferred: to add 2 times that Chinese liquor amount is Styrax quality) that step (3) adds Chinese liquor amount.
Described a kind of preparation method for the treatment of the liniment of scabies, it is doubly (preferred: to add 8-9 times that amount of alcohol is carried crude drug quality that step (4) adds the 7-10 that amount of alcohol is carried crude drug quality; Be more preferably: add 8.5 times that amount of alcohol is carried crude drug quality).
Described a kind of preparation method for the treatment of the liniment of scabies, time of each reflux, extract, of step (4) be 1-3 hour (preferred: the time of each reflux, extract, is 1.5-2.5 hour; Be more preferably: the time of each reflux, extract, is 2 hours).
Present invention also offers the described a kind of application of liniment when preparing the medicine for the treatment of scabies for the treatment of scabies.
A kind of liniment scientific formulation for the treatment of scabies provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, therapeutic effect is good, and cure rate is high, can effectively effect a radical cure this disease;
2, this formula is summed up through clinical practice for many years and is formed, and has effect of killing parasites for relieving itching, detumescence sore;
3, the present invention is that Chinese medicine herbaceous plant is made, safe and non-stimulating, has no side effect.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat a liniment for scabies, be prepared from (every part of 10g) primarily of following bulk drugs: Semen Platycladi 9 parts, Caulis Viburni Macrocephali 11 parts, Semen Seu Fructus Millettiae Pachycarpae 8 parts, Herba Hydrocotyles 10 parts, distortion grass 9 parts, Folium Sophorae viciifoliae 11 parts, Cortex Cleistocalycis Operculati 7 parts, Herba Centellae 10 parts, Cortex Dictamni 8 parts, Fructus Cnidii 7 parts, Flos Lonicerae 13 parts, Herba Patriniae 10 parts, Semen Abri Precatorii 8 parts, Hydrargyrum Oxydatum Crudum Bottom 6 parts, Cortex ulmi pumilae 9 parts, Styrax 7 parts.Above-mentioned a kind of preparation method for the treatment of the liniment of scabies is:
(1) get Semen Platycladi, Semen Seu Fructus Millettiae Pachycarpae, Fructus Cnidii and Semen Abri Precatorii remove impurity to clean, add clean sandy soil and mix thoroughly, be placed in frying pan, moderate heat stir-fries 8 minutes, takes out, eliminates sandy soil;
(2) Cortex Cleistocalycis Operculati, Cortex Dictamni and Cortex ulmi pumilae removing impurity is got, be cut into thread, mix with Testa Tritici (mass ratio of Testa Tritici and crude drug is 1:8), the rice vinegar adding crude drug quality 0.2 times mixes moistening thoroughly 12 minutes, is placed in frying pan, and moderate heat stir-fries to having and smolders, take out, sieve removes Testa Tritici, cools, pulverized 80 mesh sieves together with step (1) made crude drug;
(3) cleaned by Styrax, put into container, heating in water bath, to melting, filters, and removing impurity, adds the Chinese liquor of Styrax quality 1 times, be placed in electrothermostat, and 115 DEG C of heated at constant temperature 10 minutes are taken out;
(4) Caulis Viburni Macrocephali, Herba Hydrocotyles, distortion grass, Folium Sophorae viciifoliae, Herba Centellae, Flos Lonicerae, Herba Patriniae and Hydrargyrum Oxydatum Crudum Bottom are cleaned remove impurity, be placed in steamer, add vinegar water and steam 14 minutes, take out chopping, mix with step (2) gained medicated powder, be placed in container, the ethanol (amount of alcohol is 7 times of carried crude drug quality) adding 75% leaves standstill 15 minutes, reflux, extract, three times, and the time of each reflux, extract, is 1 hour, merge three gained extracting solution, and reclaim ethanol extremely without alcohol taste;
(5) by step (3) (4) made crude drug and extracting solution mixing, add adjuvant mix homogeneously, encapsulate and obtain liniment.
embodiment 2treat a liniment for scabies, be prepared from (every part of 10g) primarily of following bulk drugs: Semen Platycladi 16 parts, Caulis Viburni Macrocephali 15 parts, Semen Seu Fructus Millettiae Pachycarpae 13 parts, Herba Hydrocotyles 14 parts, distortion grass 16 parts, Folium Sophorae viciifoliae 17 parts, Cortex Cleistocalycis Operculati 16 parts, Herba Centellae 16 parts, Cortex Dictamni 12 parts, Fructus Cnidii 15 parts, Flos Lonicerae 18 parts, Herba Patriniae 17 parts, Semen Abri Precatorii 14 parts, Hydrargyrum Oxydatum Crudum Bottom 15 parts, Cortex ulmi pumilae 13 parts, Styrax 14 parts.Above-mentioned a kind of preparation method for the treatment of the liniment of scabies is:
(1) get Semen Platycladi, Semen Seu Fructus Millettiae Pachycarpae, Fructus Cnidii and Semen Abri Precatorii remove impurity to clean, add clean sandy soil and mix thoroughly, be placed in frying pan, moderate heat stir-fries 16 minutes, takes out, eliminates sandy soil;
(2) Cortex Cleistocalycis Operculati, Cortex Dictamni and Cortex ulmi pumilae removing impurity is got, be cut into thread, mix with Testa Tritici (mass ratio of Testa Tritici and crude drug is 1:8), the rice vinegar adding crude drug quality 0.5 times mixes moistening thoroughly 24 minutes, is placed in frying pan, and moderate heat stir-fries to having and smolders, take out, sieve removes Testa Tritici, cools, pulverized 140 mesh sieves together with step (1) made crude drug;
(3) cleaned by Styrax, put into container, heating in water bath, to melting, filters, and removing impurity, adds the Chinese liquor of Styrax quality 3 times, be placed in electrothermostat, and 115 DEG C of heated at constant temperature 20 minutes are taken out;
(4) Caulis Viburni Macrocephali, Herba Hydrocotyles, distortion grass, Folium Sophorae viciifoliae, Herba Centellae, Flos Lonicerae, Herba Patriniae and Hydrargyrum Oxydatum Crudum Bottom are cleaned remove impurity, be placed in steamer, add vinegar water and steam 28 minutes, take out chopping, mix with step (2) gained medicated powder, be placed in container, the ethanol (amount of alcohol is 10 times of carried crude drug quality) adding 75% leaves standstill 15 minutes, reflux, extract, three times, and the time of each reflux, extract, is 3 hours, merge three gained extracting solution, and reclaim ethanol extremely without alcohol taste;
(5) by step (3) (4) made crude drug and extracting solution mixing, add adjuvant mix homogeneously, encapsulate and obtain liniment.
Model case: xxx, male, 48 years old.Medical history: before one week, a small amount of erythema appears in patient's fossa cubitalis place, comparatively itches, erythrosis after scratching, scratch is obvious, after spread to whole body pruritus gradually, be distributed with little pimple, scratch rear water outlet, skin is hardening, and thickens sign, after edible maror, aggravation, to examination in hospital, is diagnosed as scabies.
Use this example gained liniment, first clean affected part, then uniform application is in affected part, one day 2-3 time, within seven days, be a course for the treatment of, after patient uses a course for the treatment of, pruritis obviously alleviates, after using two courses for the treatment of, patient skin recovers normal, and pimple disappears, and patient fully recovers, follow up a case by regular visits to after 1 year, the state of an illness does not recur.
embodiment 3treat a liniment for scabies, be prepared from (every part of 10g) primarily of following bulk drugs: Semen Platycladi 11 parts, Caulis Viburni Macrocephali 12 parts, Semen Seu Fructus Millettiae Pachycarpae 9 parts, Herba Hydrocotyles 11 parts, distortion grass 11 parts, Folium Sophorae viciifoliae 13 parts, Cortex Cleistocalycis Operculati 9 parts, Herba Centellae 12 parts, Cortex Dictamni 9 parts, Fructus Cnidii 9 parts, Flos Lonicerae 14 parts, Herba Patriniae 12 parts, Semen Abri Precatorii 10 parts, Hydrargyrum Oxydatum Crudum Bottom 8 parts, Cortex ulmi pumilae 10 parts, Styrax 9 parts.Above-mentioned a kind of preparation method for the treatment of the liniment of scabies is:
(1) get Semen Platycladi, Semen Seu Fructus Millettiae Pachycarpae, Fructus Cnidii and Semen Abri Precatorii remove impurity to clean, add clean sandy soil and mix thoroughly, be placed in frying pan, moderate heat stir-fries 10 minutes, takes out, eliminates sandy soil;
(2) Cortex Cleistocalycis Operculati, Cortex Dictamni and Cortex ulmi pumilae removing impurity is got, be cut into thread, mix with Testa Tritici (mass ratio of Testa Tritici and crude drug is 1:8), the rice vinegar adding crude drug quality 0.3 times mixes moistening thoroughly 16 minutes, is placed in frying pan, and moderate heat stir-fries to having and smolders, take out, sieve removes Testa Tritici, cools, pulverized 100 mesh sieves together with step (1) made crude drug;
(3) cleaned by Styrax, put into container, heating in water bath, to melting, filters, and removing impurity, adds the Chinese liquor of Styrax quality 1 times, be placed in electrothermostat, and 115 DEG C of heated at constant temperature 12 minutes are taken out;
(4) Caulis Viburni Macrocephali, Herba Hydrocotyles, distortion grass, Folium Sophorae viciifoliae, Herba Centellae, Flos Lonicerae, Herba Patriniae and Hydrargyrum Oxydatum Crudum Bottom are cleaned remove impurity, be placed in steamer, add vinegar water and steam 18 minutes, take out chopping, mix with step (2) gained medicated powder, be placed in container, the ethanol (amount of alcohol is 8 times of carried crude drug quality) adding 75% leaves standstill 15 minutes, reflux, extract, three times, and the time of each reflux, extract, is 1.5 hours, merge three gained extracting solution, and reclaim ethanol extremely without alcohol taste;
(5) by step (3) (4) made crude drug and extracting solution mixing, add adjuvant mix homogeneously, encapsulate and obtain liniment.
embodiment 4treat a liniment for scabies, be prepared from (every part of 10g) primarily of following bulk drugs: Semen Platycladi 14 parts, Caulis Viburni Macrocephali 14 parts, Semen Seu Fructus Millettiae Pachycarpae 12 parts, Herba Hydrocotyles 13 parts, distortion grass 14 parts, Folium Sophorae viciifoliae 15 parts, Cortex Cleistocalycis Operculati 14 parts, Herba Centellae 14 parts, Cortex Dictamni 11 parts, Fructus Cnidii 13 parts, Flos Lonicerae 17 parts, Herba Patriniae 15 parts, Semen Abri Precatorii 12 parts, Hydrargyrum Oxydatum Crudum Bottom 13 parts, Cortex ulmi pumilae 12 parts, Styrax 12 parts.Above-mentioned a kind of preparation method for the treatment of the liniment of scabies is:
(1) get Semen Platycladi, Semen Seu Fructus Millettiae Pachycarpae, Fructus Cnidii and Semen Abri Precatorii remove impurity to clean, add clean sandy soil and mix thoroughly, be placed in frying pan, moderate heat stir-fries 14 minutes, takes out, eliminates sandy soil;
(2) Cortex Cleistocalycis Operculati, Cortex Dictamni and Cortex ulmi pumilae removing impurity is got, be cut into thread, mix with Testa Tritici (mass ratio of Testa Tritici and crude drug is 1:8), the rice vinegar adding crude drug quality 0.4 times mixes moistening thoroughly 20 minutes, is placed in frying pan, and moderate heat stir-fries to having and smolders, take out, sieve removes Testa Tritici, cools, pulverized 120 mesh sieves together with step (1) made crude drug;
(3) cleaned by Styrax, put into container, heating in water bath, to melting, filters, and removing impurity, adds the Chinese liquor of Styrax quality 3 times, be placed in electrothermostat, and 115 DEG C of heated at constant temperature 18 minutes are taken out;
(4) Caulis Viburni Macrocephali, Herba Hydrocotyles, distortion grass, Folium Sophorae viciifoliae, Herba Centellae, Flos Lonicerae, Herba Patriniae and Hydrargyrum Oxydatum Crudum Bottom are cleaned remove impurity, be placed in steamer, add vinegar water and steam 24 minutes, take out chopping, mix with step (2) gained medicated powder, be placed in container, the ethanol (amount of alcohol is 9 times of carried crude drug quality) adding 75% leaves standstill 15 minutes, reflux, extract, three times, and the time of each reflux, extract, is 2.5 hours, merge three gained extracting solution, and reclaim ethanol extremely without alcohol taste;
(5) by step (3) (4) made crude drug and extracting solution mixing, add adjuvant mix homogeneously, encapsulate and obtain liniment.
Model case: xxx, women, 23 years old.Main suit: finger is sewed with vesicle, evacuate distribution, pruritus unbearably, after scratching, has clear liquid to flow out, desquamation after vesicle drying, and spreads to other parts of health, red swelling of the skin pain, and keratinization thickens, and to examination in hospital, is diagnosed as scabies.
Through this example of people's recommendation gained liniment, first clean affected part, then uniform application is in affected part, one day 2-3 time, it within seven days, is a course for the treatment of, patient uses a course for the treatment of, and vesicle is shrivelled gradually to come off, and pruritis is alleviated, after adhering to two courses for the treatment of of use, skin lesion place recovers normal completely, and without other uncomfortable diseases, patient fully recovers.
embodiment 5treat a liniment for scabies, be prepared from (every part of 10g) primarily of following bulk drugs: Semen Platycladi 12.5 parts, Caulis Viburni Macrocephali 13 parts, Semen Seu Fructus Millettiae Pachycarpae 10.5 parts, Herba Hydrocotyles 12 parts, distortion grass 12.5 parts, Folium Sophorae viciifoliae 14 parts, Cortex Cleistocalycis Operculati 11.5 parts, Herba Centellae 13 parts, Cortex Dictamni 10 parts, Fructus Cnidii 11 parts, Flos Lonicerae 15.5 parts, Herba Patriniae 13.5 parts, Semen Abri Precatorii 11 parts, Hydrargyrum Oxydatum Crudum Bottom 10.5 parts, Cortex ulmi pumilae 11 parts, Styrax 10.5 parts.Above-mentioned a kind of preparation method for the treatment of the liniment of scabies is:
(1) get Semen Platycladi, Semen Seu Fructus Millettiae Pachycarpae, Fructus Cnidii and Semen Abri Precatorii remove impurity to clean, add clean sandy soil and mix thoroughly, be placed in frying pan, moderate heat stir-fries 12 minutes, takes out, eliminates sandy soil;
(2) Cortex Cleistocalycis Operculati, Cortex Dictamni and Cortex ulmi pumilae removing impurity is got, be cut into thread, mix with Testa Tritici (mass ratio of Testa Tritici and crude drug is 1:8), the rice vinegar adding crude drug quality 0.35 times mixes moistening thoroughly 18 minutes, is placed in frying pan, and moderate heat stir-fries to having and smolders, take out, sieve removes Testa Tritici, cools, pulverized 110 mesh sieves together with step (1) made crude drug;
(3) cleaned by Styrax, put into container, heating in water bath, to melting, filters, and removing impurity, adds the Chinese liquor of Styrax quality 2 times, be placed in electrothermostat, and 115 DEG C of heated at constant temperature 15 minutes are taken out;
(4) Caulis Viburni Macrocephali, Herba Hydrocotyles, distortion grass, Folium Sophorae viciifoliae, Herba Centellae, Flos Lonicerae, Herba Patriniae and Hydrargyrum Oxydatum Crudum Bottom are cleaned remove impurity, be placed in steamer, add vinegar water and steam 21 minutes, take out chopping, mix with step (2) gained medicated powder, be placed in container, the ethanol (amount of alcohol is 8.5 times of carried crude drug quality) adding 75% leaves standstill 15 minutes, reflux, extract, three times, and the time of each reflux, extract, is 2 hours, merge three gained extracting solution, and reclaim ethanol extremely without alcohol taste;
(5) by step (3) (4) made crude drug and extracting solution mixing, add adjuvant mix homogeneously, encapsulate and obtain liniment.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Semen Platycladi: base is former: be the dry mature kernal of Cupressaceae plant Cacumen Platycladi.Character: matter is soft, High oleic.Feeble QI is fragrant, lightly seasoned.Nature and flavor with return through: sweet, flat.GUIXIN, kidney, large intestine channel.Function with cure mainly: tranquilizing by nourishing the heart, loosening bowel to relieve constipation, hidroschesis.For deficiency of YIN-blood, fidgets due to deficiency is had a sleepless night, severe palpitation, dryness of the intestine constipation, night sweat due to yin deficiency.
Caulis Viburni Macrocephali: base is former: be the stem of caprifoliaceae plant silk ball Caulis Viburni Dilatati.Nature and flavor: bitter in the mouth; Cool in nature.Function cures mainly: dampness removing to stop itchin.Main scabies is fresh; Wet rotten pain of itching.
Semen Seu Fructus Millettiae Pachycarpae: base is former: be the seed of leguminous plant Millettia pachycarpa Benth.Nature and flavor: bitter; Pungent; Hot in nature; Large poison.Gui Jing: spleen; Stomach warp.Function cures mainly: counteracting toxic substances pain relieving; Eliminating stagnated food and killing intestinal worms.Main scabies skin ulcer leprosy; Eruptive disease is suffered from abdominal pain; Infantile malnutrition.
Herba Hydrocotyles: base is former: be the herb of samphire Herba Hydrocotyles and Hydrocotyle sibthorpioides lam.Var.Batvachium (Hand.-Mazz.) et shan..Chemical analysis: herb is containing flavones ingredient: Quercetin, Quercetin-3-galactoside, isorhamnetin, Quercetin-3-O-β-D-(6-caffeoyl galactoside).Again containing wooden body composition, left-handed sesamin and Mus Body components: stigmasterol.Not containing coumarin.Nature and flavor: acrid in the mouth; Micro-hardship; Cool in nature.Function cures mainly: clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main jaundice; Dysentery; Edema; Stranguria; Corneal nebula; Larynx swells; Carbuncle sore tumefacting virus; Herpes zoster; Traumatic injury.
Distortion grass: base is former: be the herb of Euphorbiaceae Cactus platymiscium Cactus.The property of medicine: sour, micro-puckery, cold, mild toxicity.Function cures mainly: heat-clearing and toxic substances removing, and dissipating blood stasis stops blooding.Treatment of ulcer toxic swelling, scabies, conjunctival congestion is red and swollen, traumatic injury congestive edema, fracture, traumatic hemorrhage.
Folium Sophorae viciifoliae: base is former: be the leaf of leguminous plant Radix Sophorae Viciifoliae.Nature and flavor: bitter in the mouth; Cool in nature.Gui Jing: the heart; Kidney channel.Function cures mainly: removing heat from blood; Removing toxic substances; Parasite killing.Main epistaxis; Have blood in stool; Furuncle swelling toxin; Scabies; Scald; Trichomonas vaginitis.
Cortex Cleistocalycis Operculati: base is former: be the bark of myrtle water father-in-law.Nature and flavor: bitter in the mouth; Pungent; Cool in nature.Function cures mainly: heat-clearing and toxic substances removing; Dampness; Parasite killing.Main beriberi wets rotten; Eczema; Scabies; Scrotum carbuncle; Burn and scald.
Herba Centellae: base is former: be the herb of samphire Herba Centellae.Nature and flavor: bitter in the mouth; Pungent; Cold in nature.Gui Jing: return lung; Spleen; Kidney; Urinary bladder channel.Function cures mainly: clearing away heat-damp and promoting diuresis; Promoting blood circulation and hemostasis; Removing toxic substances and promoting subsidence of swelling.Main heating; Cough with asthma; Laryngopharynx swelling and pain; Dysentery; Jaundice due to damp-heat; Edema; Stranguria; Hematuria; Epistaxis; Dysmenorrhea; Metrorrhagia; Erysipelas; Scrofula; Parent's pyogenic infections from tumour or sore; Herpes zoster; Treating swelling and pain by traumatic injury; Traumatic hemorrhage; Snake bite and insect sting.
Cortex Dictamni: base is former: be the root bark of rutaceae shaggy-fruited dittany and Dictamnus angustifolius.Nature and flavor: bitter; Salty; Cold.Gui Jing: enter spleen, stomach warp.Function cures mainly: heat clearing and damp drying; Dispelling wind for relieving itching; Removing toxic substances.Rubella caused by the hot noxious dampness of main air; Eczema; Scabies; Jaundice; Damp-heat arthralgia.
Fructus Cnidii: base is former: be the fruit of samphire cnidium monnieri.Nature and flavor with return through: pungent, bitter, temperature; Slightly poisonous.Return kidney channel.Dampness is had to dispel the wind, killing parasites for relieving itching, effect of warming the kidney to invigorate YANG.For pudendal pruritus leukorrhagia, eczema pruritus, arthralgia chiefly caused by damp pathogen lumbago, impotence due to deficiency of the kidney, cold womb is infertile.
Flos Lonicerae: sweet in the mouth, micro-hardship, cold nature.Have heat-clearing and toxic substances removing, expelling pathogenic factors from the exterior is gone out, effect of stomach function regulating preventing or arresting vomiting, stops up resistance, disorder of stomach-QI, fever and irritability for pathogenic heat.
Herba Patriniae: base is former: be the herb of Valerianaceae plant Patrinia scabiosaefolia Fisch and patrima villosa.Nature and flavor: acrid in the mouth; Bitter; Cold nature.Gui Jing: return rib; Large intestine; Liver Channel.Function cures mainly: heat-clearing and toxic substances removing; To invigorate blood circulation evacuation of pus.Main intestinal carbuncle; Lung abscess; Carbuncle; Dysentery; The stagnant stomachache of the stasis of blood in puerperal.
Semen Abri Precatorii: base is former: be the mature seed of leguminous plant Semen Abri Precatorii.Nature and flavor: arduous; Flat; Poisonous.Gui Jing: the heart; Lung meridian.Function cures mainly: heat-clearing and toxic substances removing, eliminates the phlegm, parasite killing.Main pain skin ulcer, parotitis, scabies, rheumatic ostalgia.
Hydrargyrum Oxydatum Crudum Bottom: base is former: for staying the residue in the bottom of a pan after refining Hydrargyri Oxydum Rubrum.Nature and flavor: bitter; Flat.Gui Jing: lung meridian.Function cures mainly: killing parasites for relieving itching; Removing dampness granulation promoting.Main scabies; Eczema; Impetigo.
Cortex ulmi pumilae: base is former: be bark, the root bark of Ulmaceae elm.Nature and flavor: sweet; Cold nature.Gui Jing: lung; Spleen; Urinary bladder channel.Function cures mainly: relieving stranguria by diuresis; Eliminate the phlegm; Subduing swelling and detoxicating.Main dysuria; Stranguria with turbid discharge; Leukorrhagia; Cough with asthma abundant expectoration; Insomnia; Interior external haemorrhage, difficult labour retention of dead fetus; Carbuncle scrofula; Tinea alba; Scabies.
Styrax: base is former: be the resin secreted by Hamamelidaceae Plants Styrax tree.Nature and flavor: pungent; Sweet; Temperature; Nontoxic.Gui Jing: lung; Liver; Spleen; Stomach warp.Function cures mainly: sensible ward off dirty; Dissipating depression of QI eliminating phlegm; Promoting the circulation of QI to relieve pain.Main apoplexy; Syncope due to accumulation of phlegm; The constipation due to cold pathogen disease lost consciousness; Pyrexial malaria; Infantile convulsion; Turbid damp vomiting and diarrhea; Sudden attack of pain in the chest and abdomen and chilblain; Scabies.
test example 1a kind of clinical practice for the treatment of the liniment (embodiment 5) of scabies of gained of the present invention:
Choose crowd: in February ,-2015 in March, 2014, according to medical case history, be diagnosed as patient 217 example of scabies five hospitals' screenings, age 10-65 year, 39.4 ± 1.8 years old mean age, course of disease 3-40 days, wherein male patient 119 example, female patient 98 example.All there is direct or indirect contagion medical history in all patients, has typical clinical manifestation, and can microscopy to sarcoptic mite or worm's ovum.
Before test, patient is divided into two groups at random, experimental group 122 example and matched group 95 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group uses products obtained therefrom of the present invention, first cleans affected part, and then uniform application is in affected part, one day 2-3 time, within seven days, is a course for the treatment of; Matched group uses other conventional medicines (sulphur ointment, tinea ointment, daktarin etc.).Treatments period carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) cures: clinical symptoms and sign are eliminated, and skin surface is normal, and microscopy is without acaricide; (2) effective: clinical symptoms and sign are eliminated substantially, and the place of scabbing has neoplastic skin to grow, microscopy display is without acaricide; (3) invalid: symptom is without improvement or increase the weight of.Total effective rate=cure rate+effective percentage.
Clinical effectiveness: after the treatment of two courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
As shown in Table 1, the total effective rate of experimental group is 97.5%, and the total effective rate 82.1% of matched group, significantly lower than the therapeutic effect of experimental group, illustrate that products obtained therefrom of the present invention is evident in efficacy, cure rate is high.Treatments period, all there is not untoward reaction in experimental group patient, and allergic phenomena appears in matched group patient part, and products obtained therefrom of the present invention is described, more safe and non-stimulating.
The Chinese medicine used in the present invention, Semen Platycladi can tranquilizing by nourishing the heart, Caulis Viburni Macrocephali can dampness removing to stop itchin, Semen Seu Fructus Millettiae Pachycarpae can eliminating stagnated food and killing intestinal worms, Herba Hydrocotyles, Herba Centellae can removing toxic substances and promoting subsidence of swelling, distortion grass can stop blooding by dissipating blood stasis, Folium Sophorae viciifoliae can removing pathogenic heat from blood and toxic substance from the body, and Cortex Cleistocalycis Operculati, Flos Lonicerae, Semen Abri Precatorii can heat-clearing and toxic substances removing, and Cortex Dictamni can dispelling wind for relieving itching, Fructus Cnidii, Hydrargyrum Oxydatum Crudum Bottom can killing parasites for relieving itchings, Herba Patriniae can be invigorated blood circulation evacuation of pus, and Cortex ulmi pumilae can subduing swelling and detoxicating, and Styrax can promoting the circulation of QI to relieve pain, multiple medical material combined effect, can give play to effect of removing toxic substances and promoting subsidence of swelling, killing parasites for relieving itching.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat a liniment for scabies, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Semen Platycladi 9-16; Caulis Viburni Macrocephali 11-15; Semen Seu Fructus Millettiae Pachycarpae 8-13; Herba Hydrocotyles 10-14; Distortion grass 9-16; Folium Sophorae viciifoliae 11-17; Cortex Cleistocalycis Operculati 7-16; Herba Centellae 10-16; Cortex Dictamni 8-12; Fructus Cnidii 7-15; Flos Lonicerae 13-18; Herba Patriniae 10-17; Semen Abri Precatorii 8-14; Hydrargyrum Oxydatum Crudum Bottom 6-15; Cortex ulmi pumilae 9-13; Styrax 7-14.
2. a kind of liniment for the treatment of scabies as claimed in claim 1, is characterized in that, Semen Platycladi 11-14; Caulis Viburni Macrocephali 12-14; Semen Seu Fructus Millettiae Pachycarpae 9-12; Herba Hydrocotyles 11-13; Distortion grass 11-14; Folium Sophorae viciifoliae 13-15; Cortex Cleistocalycis Operculati 9-14; Herba Centellae 12-14; Cortex Dictamni 9-11; Fructus Cnidii 9-13; Flos Lonicerae 14-17; Herba Patriniae 12-15; Semen Abri Precatorii 10-12; Hydrargyrum Oxydatum Crudum Bottom 8-13; Cortex ulmi pumilae 10-12; Styrax 9-12.
3. a kind of liniment for the treatment of scabies as claimed in claim 1, is characterized in that, Semen Platycladi 12.5; Caulis Viburni Macrocephali 13; Semen Seu Fructus Millettiae Pachycarpae 10.5; Herba Hydrocotyles 12; Distortion grass 12.5; Folium Sophorae viciifoliae 14; Cortex Cleistocalycis Operculati 11.5; Herba Centellae 13; Cortex Dictamni 10; Fructus Cnidii 11; Flos Lonicerae 15.5; Herba Patriniae 13.5; Semen Abri Precatorii 11; Hydrargyrum Oxydatum Crudum Bottom 10.5; Cortex ulmi pumilae 11; Styrax 10.5.
4. a kind of preparation method for the treatment of the liniment of scabies as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) get Semen Platycladi, Semen Seu Fructus Millettiae Pachycarpae, Fructus Cnidii and Semen Abri Precatorii remove impurity to clean, add clean sandy soil and mix thoroughly, be placed in frying pan, moderate heat stir-fry 8-16 minute (preferred: moderate heat stir-fries 10-14 minute; Be more preferably: moderate heat stir-fries 12 minutes), take out, eliminate sandy soil;
(2) get Cortex Cleistocalycis Operculati, Cortex Dictamni and Cortex ulmi pumilae removing impurity, be cut into thread, mix with Testa Tritici (mass ratio of Testa Tritici and crude drug is 1:8), add rice vinegar and mix moistening 12-24 minute thoroughly (preferably: add rice vinegar and mix moistening 16-20 minute thoroughly; Be more preferably: add rice vinegar and mix moistening thoroughly 18 minutes), be placed in frying pan, moderate heat stir-fries to having and smolders, and takes out, and sieve removes Testa Tritici, cools, pulverizes and sieves together with step (1) made crude drug;
(3) cleaned by Styrax, put into container, heating in water bath, to melting, filters, and removing impurity, adds Chinese liquor, be placed in electrothermostat, 115 DEG C heated at constant temperature 10-20 minute (preferred: heated at constant temperature 12-18 minute; Be more preferably: heated at constant temperature 15 minutes), take out;
(4) Caulis Viburni Macrocephali, Herba Hydrocotyles, distortion grass, Folium Sophorae viciifoliae, Herba Centellae, Flos Lonicerae, Herba Patriniae and Hydrargyrum Oxydatum Crudum Bottom are cleaned remove impurity, be placed in steamer, add vinegar water and steam 14-28 minute (preferably: add vinegar water and steam 18-24 minute; Be more preferably: add vinegar water and steam 21 minutes), take out chopping, mix, be placed in container with step (2) gained medicated powder, the ethanol adding 75% leaves standstill 15 minutes, and reflux, extract, three times, merges three gained extracting solution, and reclaims ethanol extremely without alcohol taste;
(5) by step (3) (4) made crude drug and extracting solution mixing, add adjuvant mix homogeneously, encapsulate and obtain liniment.
5. a kind of preparation method for the treatment of the liniment of scabies as claimed in claim 4, is characterized in that, step (2) add rice vinegar amount be the 0.2-0.5 of crude drug quality doubly (preferred: add rice vinegar amount be the 0.3-0.4 of crude drug quality doubly; Be more preferably: add 0.35 times that rice vinegar amount is crude drug quality).
6. a kind of preparation method for the treatment of the liniment of scabies as claimed in claim 4, is characterized in that, it is (preferred: to pulverize 100-120 mesh sieve that step (2) pulverized 80-140 mesh sieve; Be more preferably: pulverized 110 mesh sieves).
7. a kind of preparation method for the treatment of the liniment of scabies as claimed in claim 4, is characterized in that, it is the 1-3 of Styrax quality doubly (preferred: to add 2 times that Chinese liquor amount is Styrax quality) that step (3) adds Chinese liquor amount.
8. a kind of preparation method for the treatment of the liniment of scabies as claimed in claim 4, is characterized in that, it is doubly (preferred: to add 8-9 that amount of alcohol is carried crude drug quality doubly that step (4) adds 7-10 that amount of alcohol is carried crude drug quality; Be more preferably: add 8.5 times that amount of alcohol is carried crude drug quality).
9. a kind of preparation method for the treatment of the liniment of scabies as claimed in claim 4, is characterized in that, time of each reflux, extract, of step (4) be 1-3 hour (preferred: the time of each reflux, extract, is 1.5-2.5 hour; Be more preferably: the time of each reflux, extract, is 2 hours).
10. a kind of application of liniment when preparing the medicine for the treatment of scabies for the treatment of scabies as described in as arbitrary in claim 1-3.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105434730A (en) * | 2015-12-24 | 2016-03-30 | 徐亚丽 | External traditional Chinese medicine for treating mange |
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| CN101401895A (en) * | 2008-11-18 | 2009-04-08 | 向昌荣 | Chinese medicinal composition for treating skin disease |
| CN101590153A (en) * | 2008-05-26 | 2009-12-02 | 洪长征 | Compound skin comfort liquid |
| CN101972389A (en) * | 2010-11-08 | 2011-02-16 | 向昌荣 | Chinese medicinal composition for treating dermatosis |
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| CN101167847A (en) * | 2007-11-13 | 2008-04-30 | 杨春常 | Traditional Chinese medicinal white spirit preparation for effectively treating skin disease |
| CN101590153A (en) * | 2008-05-26 | 2009-12-02 | 洪长征 | Compound skin comfort liquid |
| CN101401895A (en) * | 2008-11-18 | 2009-04-08 | 向昌荣 | Chinese medicinal composition for treating skin disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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