CN105079572A - Pharmaceutical preparation for treating non-gonococcal urethritis - Google Patents
Pharmaceutical preparation for treating non-gonococcal urethritis Download PDFInfo
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- CN105079572A CN105079572A CN201510601687.9A CN201510601687A CN105079572A CN 105079572 A CN105079572 A CN 105079572A CN 201510601687 A CN201510601687 A CN 201510601687A CN 105079572 A CN105079572 A CN 105079572A
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Abstract
The invention belongs to the field of a traditional Chinese medicinal preparation, and in particular provides a pharmaceutical preparation for treating non-gonococcal urethritis. The pharmaceutical preparation is prepared from the following raw materials: 30 parts of pothos chinensis, 25 parts of longleaf bastardtoadflax herb, 18 parts of gynura bicolor, 25 parts of gymnocladus sinensis, 28 parts of seed of Chinese dodder, 15 parts of houttuynia cordata, 15 parts of purslane, 20 parts of rheum officinale, 25 parts of thunder god vine, 20 parts of radix sophorae flavescentis, 25 parts of Chinese lobelia, 20 parts of lophatherum gracile, 15 parts of pyrrosia lingua, 15 parts of cortex phellodendri, 15 parts of fructus kochiae, 25 parts of dianthus superbus, 15 parts of mangnolia officinalis and 5 parts of liquorice root. The pharmaceutical preparation disclosed by the invention can be used for treating non-gonococcal urethritis.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of nongonococcal urethritis and its preparation method and application.
Background technology
Urethritis refers to that urethra causes inflammation because of a variety of causes, occurs the symptoms such as secretions, dysurea or urethra discomfort.If Diplococcus gonorrhoeae (being called for short gonococcus) can be detected, be called nongonococcal urethritis; If can not find out Diplococcus gonorrhoeae, be called non-nongonococcal urethritis.Nongonococcal urethritis is a kind of more common sexually transmitted disease (STD), the features such as it has, and sickness rate is high, infectiousness is strong, incubation period short (3 ~ 5 days).For this reason, be bursting to and develop the needs that more medicines for the treatment of nongonococcal urethritis safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of nongonococcal urethritis disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of nongonococcal urethritis, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: 30 parts, Herba Pothi Chinensis, Herba Thesii Longifolii 25 parts, gynura bicolor 18 parts, Fructus Gymnocladi Chinensis 25 parts, Semen Cuscutae 28 parts, Herba Houttuyniae 15 parts, Herba Portulacae 15 parts, Radix Et Rhizoma Rhei 20 parts, Radix Tripterygii Wilfordii 25 parts, Radix Sophorae Flavescentis 20 parts, Herba Lobeliae Chinensis 25 parts, Herba Lophatheri 20 parts, Folium Pyrrosiae 15 parts, Cortex Phellodendri 15 parts, the Fructus Kochiae 15 parts, Herba Dianthi 25 parts, Cortex Magnoliae Officinalis 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of nongonococcal urethritis, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of nongonococcal urethritis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment nongonococcal urethritis medicine being used for the treatment of nongonococcal urethritis.
Herba Pothi Chinensis is Araeceae Herba Pothi Chinensis platymiscium stone Pu rattan Pothoschinensis (Raf.) Merr., with all herbal medicine.The whole year can adopt, using fresh herb or dry.Expelling wind and removing dampness, promoting blood circulation to remove blood stasis, removing food stagnancy, cough-relieving.For traumatic injury, advanced schistosomiasis hepatosplenomegaly, rheumatic arthritis, infantile malnutrition, cough; Fracture is controlled in external, otitis media, sinusitis.
Herba Thesii Longifolii is that Santalaceae plant comes into leaves the herb of Herba Thesii, and perennial herb, height is 50cm about.Stem clusters, and has obvious longitudinal furrow.Leaf stockless.Linear, long 4-4.5cm, wide 2.5mm, two ends are gradually sharp, have 3 arteries and veins.Expelling wind and clearing away heat, spasmolytic.
Gynura bicolor, Classification system: Gynurabicolor (Roxb.exWilld.) DC., for Compositae Radix Gynurae belongs to herbaceos perennial, high 50-100 centimetre, green above blade, purpling color time dry below, two sides without hair, cooling blood for hemostasis, clearing heat for detumescence.For hemoptysis, metrorrhagia, dysmenorrhea, vim and vigour pain, bronchitis, pelvic inflammatory disease, heatstroke, amebic dysentery; Wound hemorrhage is controlled in external, and ulcer does not close up for a long time, furuncle carbuncle, paronychia.The present invention adopts all herbal medicine.
Fructus Gymnocladi Chinensis, Latin is called GymnocladuschinensisBaill, is a kind of deciduous tree, stingless, up to 5-12 rice; Bark taupe and adularescent hole skin, two times even number winglike compound leaves, without stipule, rachis has groove, and quilt cover has pubescence, almost without petiole.Flower polygamy, is white or band purple, has long stalk, let droop.Pod Long Circle, flat or expand, without hair, have seed 2-4, seed is subsphaeroidal and slightly flat, black, smoothly without hair.Result between general August.Be distributed in the provinces and regions such as Jiangsu, Zhejiang, Jiangxi, Anhui, Fujian, Hubei, Hunan, Guangdong, Guangxi, Sichuan.Be born in height above sea level 150-1500 rice hillside, hill-side, shaw, fruit, containing soap element, can be washed silk, also can be used as medicine.Seed oil can make the iundustrial oils such as paint, expelling wind and removing dampness, promoting blood circulation and detumescence.For rheumatalgia, traumatic injury, furuncle swelling toxin.The present invention is with fruit medicine.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science is thought, nongonococcal urethritis is " stranguria ", categories such as " turbid urines ", the origin cause of formation of primary disease, how because of contaminated intercourse or impression is foul indirectly heresy, lead to damp and hot, bet bladder, the smoked urethra that burns forms and mostly is stagnation of QI due to depression of the liver, weakness of the spleen and stomach is done, Herba Pothi Chinensis of the present invention, Herba Thesii Longifolii, gynura bicolor, Fructus Gymnocladi Chinensis, Semen Cuscutae, Herba Houttuyniae, Herba Portulacae, Radix Et Rhizoma Rhei, Radix Tripterygii Wilfordii, Radix Sophorae Flavescentis heat-clearing and toxic substances removing, killing parasites for relieving itching is monarch drug, Herba Lobeliae Chinensis, Herba Lophatheri, Folium Pyrrosiae, Cortex Phellodendri, the Fructus Kochiae, Herba Dianthi, Cortex Magnoliae Officinalis ascending the clear and descending the turbid, dampness removing is treating stranguria, reinforcing kidney and strengthening resistance, blood circulation promoting and blood stasis dispelling is ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, treatment nongonococcal urethritis successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba Pothi Chinensis 30g, Herba Thesii Longifolii 25g, gynura bicolor 18g, Fructus Gymnocladi Chinensis 25g, Semen Cuscutae 28g, Herba Houttuyniae 15g, Herba Portulacae 15g, Radix Et Rhizoma Rhei 20g, Radix Tripterygii Wilfordii 25g, Radix Sophorae Flavescentis 20g, Herba Lobeliae Chinensis 25g, Herba Lophatheri 20g, Folium Pyrrosiae 15g, Cortex Phellodendri 15g, Fructus Kochiae 15g, Herba Dianthi 25g, Cortex Magnoliae Officinalis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba Pothi Chinensis 30g, Herba Thesii Longifolii 25g, gynura bicolor 18g, Fructus Gymnocladi Chinensis 25g, Semen Cuscutae 28g, Herba Houttuyniae 15g, Herba Portulacae 15g, Radix Et Rhizoma Rhei 20g, Radix Tripterygii Wilfordii 25g, Radix Sophorae Flavescentis 20g, Herba Lobeliae Chinensis 25g, Herba Lophatheri 20g, Folium Pyrrosiae 15g, Cortex Phellodendri 15g, Fructus Kochiae 15g, Herba Dianthi 25g, Cortex Magnoliae Officinalis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Herba Pothi Chinensis 30g, Herba Thesii Longifolii 25g, gynura bicolor 18g, Fructus Gymnocladi Chinensis 25g, Semen Cuscutae 28g, Herba Houttuyniae 15g, Herba Portulacae 15g, Radix Et Rhizoma Rhei 20g, Radix Tripterygii Wilfordii 25g, Radix Sophorae Flavescentis 20g, Herba Lobeliae Chinensis 25g, Herba Lophatheri 20g, Folium Pyrrosiae 15g, Cortex Phellodendri 15g, Fructus Kochiae 15g, Herba Dianthi 25g, Cortex Magnoliae Officinalis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment nongonococcal urethritis of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation nongonococcal urethritis case 40 example, 25 ~ 38 years old age.The shortest person of the course of disease 3 months, most elder reaches 2 years.
4.2 diagnostic criterias: 1, have unclean property contact history.2,1 ~ 3 week incubation period.3, common clinical manifestation: male patient often has serosity or mucopurulent secretion thing to flow out or urodynamic from urethral orifice.Female patient often has frequent micturition and dysuria.During as involved cervix uteri, show as inflammation and erosion, secretions increase, vagina and outer anti-pruritus, but also some patient is asymptomatic.4, secretions smear and cultivation are without gonococcus person, secretions smear, Gram’s staining or opened up (or urine after 2 ~ 3 hours) urine first and do centrifugation, taking precipitate checks, under high power lens, there are more than 10 ~ 15 polymorphonuclear leukocyte persons in every visual field, and cultivation can detect chlamydia or mycoplasma.Nongonococcal urethritis is a kind of urogenital infections caused for principal causative microorganism with chlamydia and mycoplasma, and mainly through sexual transmission, clinical course concealment, delay, clinical manifestation is slight, and often occur together upper reproductive tract infection.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: symptom all disappears; Effective: symptom obviously alleviates; Invalid: without significant change or deterioration before and after treatment.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 20 | 8 | 7 | 5 | 75 |
| Blank group | 20 | 0 | 1 | 19 | 5 |
Visible, the medicine that the present invention obtains can safe and effective treatment nongonococcal urethritis, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of nongonococcal urethritis, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: 30 parts, Herba Pothi Chinensis, Herba Thesii Longifolii 25 parts, gynura bicolor 18 parts, Fructus Gymnocladi Chinensis 25 parts, Semen Cuscutae 28 parts, Herba Houttuyniae 15 parts, Herba Portulacae 15 parts, Radix Et Rhizoma Rhei 20 parts, Radix Tripterygii Wilfordii 25 parts, Radix Sophorae Flavescentis 20 parts, Herba Lobeliae Chinensis 25 parts, Herba Lophatheri 20 parts, Folium Pyrrosiae 15 parts, Cortex Phellodendri 15 parts, the Fructus Kochiae 15 parts, Herba Dianthi 25 parts, Cortex Magnoliae Officinalis 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of nongonococcal urethritis as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of nongonococcal urethritis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment nongonococcal urethritis medicine of nongonococcal urethritis according to claim 1.
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| CN201510601687.9A CN105079572A (en) | 2015-09-19 | 2015-09-19 | Pharmaceutical preparation for treating non-gonococcal urethritis |
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| CN201510601687.9A CN105079572A (en) | 2015-09-19 | 2015-09-19 | Pharmaceutical preparation for treating non-gonococcal urethritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663843A (en) * | 2016-03-03 | 2016-06-15 | 冯字 | Pharmaceutical preparation for treating non-gonococcal urethritis |
Citations (4)
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|---|---|---|---|---|
| CN101028419A (en) * | 2007-04-16 | 2007-09-05 | 北京艺信堂医药研究所 | Chinese-medicinal preparation for treating nongonococcal urethritis |
| CN101049409A (en) * | 2007-05-16 | 2007-10-10 | 北京艺信堂医药研究所 | Preparation of Chinese traditional medicine for treating urethritis in non-gonococcus |
| CN101116715A (en) * | 2007-08-29 | 2008-02-06 | 北京艺信堂医药研究所 | Chinese patent drug for treating non-gonococcal urethritis |
| CN102078489A (en) * | 2009-11-27 | 2011-06-01 | 赵莉 | Traditional Chinese medicine preparation for non-gonococcal urethritis |
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- 2015-09-19 CN CN201510601687.9A patent/CN105079572A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028419A (en) * | 2007-04-16 | 2007-09-05 | 北京艺信堂医药研究所 | Chinese-medicinal preparation for treating nongonococcal urethritis |
| CN101049409A (en) * | 2007-05-16 | 2007-10-10 | 北京艺信堂医药研究所 | Preparation of Chinese traditional medicine for treating urethritis in non-gonococcus |
| CN101116715A (en) * | 2007-08-29 | 2008-02-06 | 北京艺信堂医药研究所 | Chinese patent drug for treating non-gonococcal urethritis |
| CN102078489A (en) * | 2009-11-27 | 2011-06-01 | 赵莉 | Traditional Chinese medicine preparation for non-gonococcal urethritis |
Non-Patent Citations (1)
| Title |
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| 姜锡斌 等: "石韦通淋汤治疗急性***", 《山东中医杂志》 * |
Cited By (1)
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| CN105663843A (en) * | 2016-03-03 | 2016-06-15 | 冯字 | Pharmaceutical preparation for treating non-gonococcal urethritis |
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