CN105031497A - Medicinal preparation for treating chronic gastritis - Google Patents
Medicinal preparation for treating chronic gastritis Download PDFInfo
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- CN105031497A CN105031497A CN201510533265.2A CN201510533265A CN105031497A CN 105031497 A CN105031497 A CN 105031497A CN 201510533265 A CN201510533265 A CN 201510533265A CN 105031497 A CN105031497 A CN 105031497A
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Abstract
The invention belongs to the field of traditional Chinese medicinal preparations, and particularly provides a medicinal preparation for treating chronic gastritis. The medicinal preparation is prepared from the following raw materials: 26 parts of thickleaf croton root, 18 parts of wang mucuna stem, 25 parts of longan leaves, 18 parts of falsenettleleaf pepper stem, 20 parts of radix scrophulariae, 15 parts of salviae miltiorrhizae, 20 parts of magnolia officinalis, 20 parts of rhizoma cyperi, 25 parts of pinellia ternata, 25 parts of poria cocos, 18 parts of ligusticum wallichii, 20 parts of cinnamon, 15 parts of coptis chinensis, 18 parts of fructus amomi, 15 parts of pollen typhae and 5 parts of licorice root. The medicinal preparation can be used for treating chronic gastritis.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of chronic gastritis and its preparation method and application.
Background technology
Chronic gastritis means the various chronic gastric Mucosal inflammatory pathological changes that different pathogeny causes, and be a kind of commonly encountered diseases, its sickness rate ranks first in various gastropathy.Since fiberendoscope extensive use, primary disease understanding is significantly improved.Common chronic superficial gastritis, chronic erosive gastritis and chronic atrophic gastritis.The intestinal epithelial metaplasia of the latter's mucosa, often involves cardia, reduces, also can involve body of stomach, with the forfeiture of secreting acid gland, cause gastric acid, the minimizing of pepsin and endogenous factors with G cell loss and gastrin secretion.For this reason, be bursting to and develop the needs that more medicines for the treatment of chronic gastritis safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of chronic gastritis disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of chronic gastritis, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Radix Crotonis Crassifolii 26 parts, Caulis Mucunae Wangii 18 parts, Folium Longan 25 parts, Caulis Piperis Boehmeriaefolii 18 parts, Radix Scrophulariae 20 parts, Radix Salviae Miltiorrhizae 15 parts, Cortex Magnoliae Officinalis 20 parts, Rhizoma Cyperi 20 parts, the Rhizoma Pinelliae 25 parts, 25 parts, Poria, Rhizoma Chuanxiong 18 parts, Cortex Cinnamomi 20 parts, Rhizoma Coptidis 15 parts, Fructus Amomi 18 parts, Pollen Typhae 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of chronic gastritis, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of chronic gastritis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment chronic gastritis medicine being used for the treatment of chronic gastritis.
Radix Crotonis Crassifolii is Euphorbiaceae Fructus Crotonis platymiscium Radix Crotonis Crassifolii CrotoncrassifoliusGeisel. [C.chinensisBenth.], is used as medicine with root.Autumn and winter uproot, and clean, and section, dries for subsequent use.Treat for stomachache, flatulence, rheumatic arthralgia, traumatic injury, pharyngalgia, angina pectoris, venom.
Caulis Mucunae Wangii is the stem of leguminous plant close fine hair mucuna or long pod mucuna.Relaxing muscles and tendons and activating QI and blood in the collateral, regulating menstruation.Dispelling the wind and dampness pathogens osteodynia, poliomyelitis sequela, menoxenia.
Folium Longan is Sapindaceae Euphoria plant Arillus Longan DimocarpuslonganLour., and be used as medicine with leaf, the whole year can adopt.Micro-hardship, flat.Heat-clearing and toxic substances removing, expelling pathogen from the exterior and eliminating dampness by diuresis.For preventing influenza, epidemic cerebrospinal meningitis, flu, intestinal is scorching; Eczema scrotum is controlled in external.
Caulis Piperis Boehmeriaefolii is the Herb of Piperaceae plant folium urticae Fructus Piperis.Relaxing muscles and tendons and activating QI and blood in the collateral, warming the meridian dampness removing, promoting the circulation of QI to relieve pain.Dispelling the wind and dampness pathogens, menoxenia, stomachache, traumatic injury.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science claims chronic gastritis to be demented disease, what think chronic gastritis is be trouble by wind, fire, expectorant, the stasis of blood, the present invention is mainly to get rid of vehement in knot, liver-fire in phlegm-fire in patient body, phlegm stagnation knot, rock jujube tree, Rhizoma Anemones Altaicae, Cremanthodium stenactininum Diels., Herba Lepisori Contorti, conveniently perfume, the refreshment of Calyx seu Fructus physalis key, regulating the flow of vital energy is strongly fragrant is monarch drug, it is ministerial drug that Ramulus Uncariae Cum Uncis, Radix Alangii, Radix Curcumae, Pumex, Poria, Os Draconis are calmed the nerves relieving convulsion, Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis, Semen Ziziphi Spinosae, Radix Glycyrrhizae are adjuvant, the mutual compatibility of full side, treatment chronic gastritis successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get rock jujube tree 20g, Rhizoma Anemones Altaicae 18g, Cremanthodium stenactininum Diels. 25g, Herba Lepisori Contorti 18g, fragrant 20g conveniently, Calyx seu Fructus physalis 28g, Ramulus Uncariae Cum Uncis 25g, Radix Alangii 20g, Radix Curcumae 25g, Pumex 20g, Poria 18g, Os Draconis 20g, Radix Et Rhizoma Rhei 15g, Radix Sophorae Flavescentis 18g, Semen Ziziphi Spinosae 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get rock jujube tree 20g, Rhizoma Anemones Altaicae 18g, Cremanthodium stenactininum Diels. 25g, Herba Lepisori Contorti 18g, fragrant 20g conveniently, Calyx seu Fructus physalis 28g, Ramulus Uncariae Cum Uncis 25g, Radix Alangii 20g, Radix Curcumae 25g, Pumex 20g, Poria 18g, Os Draconis 20g, Radix Et Rhizoma Rhei 15g, Radix Sophorae Flavescentis 18g, Semen Ziziphi Spinosae 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get rock jujube tree 20g, Rhizoma Anemones Altaicae 18g, Cremanthodium stenactininum Diels. 25g, Herba Lepisori Contorti 18g, fragrant 20g conveniently, Calyx seu Fructus physalis 28g, Ramulus Uncariae Cum Uncis 25g, Radix Alangii 20g, Radix Curcumae 25g, Pumex 20g, Poria 18g, Os Draconis 20g, Radix Et Rhizoma Rhei 15g, Radix Sophorae Flavescentis 18g, Semen Ziziphi Spinosae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment chronic gastritis of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation chronic gastritis case 50 example, wherein man 25 example, female 25 example, 18 ~ 54 years old age.The shortest person of the course of disease 4 months, most elder reaches 25 years.
4.2 diagnostic criterias: the symptom of chronic gastritis, sign, without specificity, can not, as the foundation of diagnosis, be made a definite diagnosis main by gastroscope and gastric mucosa living tissue pathologic finding.
(1) age: many above middle age, the course of disease is long, often has chronic superficial gastritis medical history.
(2) symptom and sign: long-term ingestion is bad, gastral cavilty portion distension is uncomfortable, poor appetite, weak, become thin, anemia etc.
(3) 1. gastric mucosa color is thin out in gastroscopy; 2. under mucosa, blood vessel is shown in thoroughly; 3. duplicature is tiny even disappears; 4. when atrophic gastritis is with body of gland cervical region hyperplasia or intestinal epithelial metaplasia, the coarse injustice of mucous membrane surface, in graininess or nodositas, visible pseudopolyp is formed sometimes, and under mucosa, the feature of exposed vessel is often covered; 5. atrophy mucosa fragility increases, easily hemorrhage, and can have rotten to the corn stove; 6. atrophic gastritis simultaneously with the performance of chronic superficial gastritis, as congested erythema, can adhere to mucus, and reflective enhancing etc.
(4) the body of gland atrophy that pathologic finding is 1. intrinsic in gastric mucosa; 2. life is changed; 3. hypertrophy; 4. canceration.
(5) the lab testing 1. many anacidities of gastric analysis A type CAG patient or low acid, Type B CAG patient can normal or low acid; 2. pepsinogen measures pepsin reason cell secretes, and during atrophic gastritis, blood and the pepsinogen content in urinating reduce; 3. the G emiocytosis gastrin of serum gastrin determination gastric antrum portion mucosa.A type CAG patient, serum gastrin Chang Mingxian increases; Type B CAG patient Antral atrophy, directly affects G emiocytosis gastrin function, and serum gastrin is lower than normally; 4. immunologic test parietal cell antibody (PCA), intrinsic factor antibody (IFA), gastrin secretion cell antibody (GCA) measure, and can be used as the auxiliary diagnosis of atrophic gastritis and typing thereof.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: clinical symptoms all disappears, and test chamber inspection is normal.Take a turn for the better: clinical symptom relief, the state of an illness is controlled, lab testing improvement or normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 25 | 5 | 16 | 4 | 84 |
| Blank group | 25 | 2 | 1 | 22 | 12 |
Visible, the medicine that the present invention obtains can safe and effective treatment chronic gastritis, and has no side effect.
4.6 Zhangs, female, 29 years old, suffers from chronic gastritis 2 years, shows as long-term ingestion bad, and gastral cavilty portion distension is uncomfortable, poor appetite, weak, become thin, anemia, lab testing confirmation is chronic gastritis.Give the Chinese medicine that granule embodiment of the present invention provides, after 2 courses for the treatment of, clinical symptoms all disappears, and test chamber inspection is normal.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of chronic gastritis, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Radix Crotonis Crassifolii 26 parts, Caulis Mucunae Wangii 18 parts, Folium Longan 25 parts, Caulis Piperis Boehmeriaefolii 18 parts, Radix Scrophulariae 20 parts, Radix Salviae Miltiorrhizae 15 parts, Cortex Magnoliae Officinalis 20 parts, Rhizoma Cyperi 20 parts, the Rhizoma Pinelliae 25 parts, 25 parts, Poria, Rhizoma Chuanxiong 18 parts, Cortex Cinnamomi 20 parts, Rhizoma Coptidis 15 parts, Fructus Amomi 18 parts, Pollen Typhae 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of chronic gastritis as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of chronic gastritis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment chronic gastritis medicine of chronic gastritis according to claim 1.
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| CN105267639A (en) * | 2015-11-25 | 2016-01-27 | 苏州枫灵医药科技有限公司 | Pharmaceutical preparation used for treating chronic gastritis |
| CN105770728A (en) * | 2016-03-03 | 2016-07-20 | 冯字 | Medicinal preparation used for treating chronic gastritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105267639A (en) * | 2015-11-25 | 2016-01-27 | 苏州枫灵医药科技有限公司 | Pharmaceutical preparation used for treating chronic gastritis |
| CN105770728A (en) * | 2016-03-03 | 2016-07-20 | 冯字 | Medicinal preparation used for treating chronic gastritis |
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Application publication date: 20151111 |