CN105073777B - 用于治疗癌症的涉及抗密蛋白18.2抗体的组合疗法 - Google Patents
用于治疗癌症的涉及抗密蛋白18.2抗体的组合疗法 Download PDFInfo
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Abstract
Description
细胞系 | 接种的细胞/孔 |
BxPC3-LVT | 5000 |
BxPC3 | 5000 |
Panc05.04 | 5000 |
BxPC3-LVT | 5000 |
CAPAN1-LVT | 5000 |
DANG | 2000 |
MiaPaCa-2-LVT | 7000 |
Patu8988S | 10000 |
Patu8988Sp3151#6 | 15000 |
原发性胰腺CA | 总计 | 阳性部分≥1%[%] | 染色强度≥2+[%] |
总计 | 141 | 69[48.9] | 62[43.9] |
导管腺癌(PDAC) | 132 | 65[49.2] | 58[44.3] |
腺泡细胞癌 | 2 | 1[50.0] | 1[50.0] |
神经内分泌癌 | 7 | 3[42.8] | 3[42.8] |
等级 | 总计病例 | 阳性部分≥1%[%] | 染色强度≥2+[%] |
1 | 15 | 13[86.7] | 12[80.0] |
2 | 71 | 39[54.9] | 36[50.7] |
3 | 35 | 9[25.7] | 7[20.0] |
原发性CA | 总计病例 | 阳性部分≥1%[%] | 染色强度≥2+[%] |
总计 | 61 | 40[65.6] | 39[63.9] |
导管腺癌(PDAC) | 42 | 38[90.5] | 37[88.1] |
腺泡细胞癌 | 1 | 0 | 0 |
神经内分泌癌 | 18 | 2[11.1] | 2[11.1] |
原发性胆道CA | 总计 | 阳性 | 阳性% |
胆道癌 | 15 | 9 | 60 |
等级 | 总计病例 | 阳性部分≥1%[%] | 染色强度≥2+[%] |
1 | 7 | 1[14.3] | 1[14.3] |
2 | 25 | 15[60.0] | 15[60.0] |
3 | 28 | 24[85.7] | 23[82.1] |
转移 | 总计 | 阳性部分≥1%[%] | 染色强度≥2+[%] |
总计 | 79 | 55[69.6] | 52[65.8] |
胰腺至*** | 44 | 31[70.5] | 28[63.6] |
胰腺至肝 | 35 | 24[68.6] | 24[68.6] |
患者ID | 原发性TU | LN转移 |
H/2011/775 3S&8D | +++(15%) | +++(25%) |
H/2011/2247 7C&7G | +++(10%) | ++(25%) |
H/2011/12675 4B&4L | +++(10%) | ++(5)% |
H/2010/15941 6SS&8H | +++(90%) | +++(90%) |
H/2010/2986 2E&2G | +++(5%) | +++(40%) |
H/2010/6709 9B&9F | +++(70%) | +++(10%) |
H/2010/11569 5A&5G | +++(80%) | ++(5%) |
H/2008/380 4A&4G | +++(60%) | +++(90%) |
H/2009/13538 5B&5E | +(20%) | +(10%) |
H/2009/11847 7C&7F | +++(15%) | ++(15%) |
H/2009/23108 4A&4J | +++(5%) | +++(70%) |
H/2009/4917 8E&8S | +++(70%) | +++(25%) |
H/2009/214183C&3L | +++(55%) | ++(70%) |
H/2009/20336 2D&2F | +++(80%) | +++(90%) |
H/2009/17768 2C&2E | ++(35%) | ++(20%) |
H/2008/13194 3A&3J | +++(35%) | +++(10%) |
H/2008/13074 3B&3C | +++(50%) | +++(50%) |
H/2008/12082 6D&6G | +++(1%) | - |
H/2008/11178 5B&1SS | +++(80%) | +++(90%) |
H/2008/28150 4B&4C | ++(15%) | ++(30%) |
H/2007/5478 4A&4J | +++(90%) | +++(90%) |
H/2007/6216 3B&3C | +++(50%) | +++(60%) |
H/2007/9047 1B&1J | +++(70%) | +++(35%) |
H/2007/13983 6C&6J | ++(15%) | ++(1%) |
H/2007/14400 6C&6J | - | - |
H/2006/5616 3J&3D | +++(35%) | +++(5%) |
H/2006/9779 3D&3K | +(5%) | +(15%) |
患者ID | 原发性肿瘤 | ***转移 | 肝转移 |
H/2011/17191-VA-VI-ISS | +++(60%) | +++(70%) | +++(1%) |
H/2010/14296 XA | +++(5-10%) | - | - |
H/2010/4157 VII A | ++(60%) | ++(30%) | +++(90%) |
H/2009/23598 VII B | +++(40%) | - | - |
H/2011/3590-III SS-VIIC-I | ++(20%) | - | - |
H/2008/10701 | +++(90%) | +++(100%) | +++(90%) |
申请人或代理人档案号342-73PCT | 国际申请号 |
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Patent Citations (1)
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CN101312989A (zh) * | 2005-11-24 | 2008-11-26 | 加尼梅德药物公司 | 用于治疗癌症的针对密蛋白-18的单克隆抗体 |
Non-Patent Citations (2)
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