CN105031217A - Pharmaceutical preparation for treating viral myocarditis - Google Patents
Pharmaceutical preparation for treating viral myocarditis Download PDFInfo
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- CN105031217A CN105031217A CN201510532104.1A CN201510532104A CN105031217A CN 105031217 A CN105031217 A CN 105031217A CN 201510532104 A CN201510532104 A CN 201510532104A CN 105031217 A CN105031217 A CN 105031217A
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations, and particularly provides a pharmaceutical preparation for treating viral myocarditis. The pharmaceutical preparation is prepared from the following raw materials in parts by weight: 25 parts of rubus pacificus hance, 18 parts of stephania sinica diels, 20 parts of viola arcuata, 18 parts of pinkflush rhododendron root, 25 parts of astragalus membranaceus, 15 parts of codonopsis pilosula, 20 parts of rhizoma atractylodis macrocephalae, 20 parts of radix ophiopogonis, 25 parts of red ginseng, 25 parts of lily, 20 parts of radix cynanchi panicullati, 15 parts of rhizoma acori graminei, 18 parts of glossy privet fruit, 15 parts of juncus roemerianus and 5 parts of liquorice. According to the pharmaceutical preparation, the viral myocarditis can be treated.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of viral myocarditis and its preparation method and application.
Background technology
Viral myocarditis refers to the myocardium limitation that viral infection causes or diffuse acute or chronic inflammatory conditions, belongs to infectious cardiomyopathy.About there is 5% patient that myocarditis occurs in viral prevalence infection period, also can be dispersed in morbidity.Clinical manifestation weight is different.Medical history is infected according to typical forerunner; Corresponding clinical manifestation; The myocardial damage evidence of electrocardiogram, myocardial injury markers, ultrasonic cardiography display considers this diagnosis, makes a definite diagnosis and depends on endomyocardial biopsy.Current without specificity therapeutic method, treat mainly for viral infection and myocardial inflammation.Most patients recovery from illness after suitable treatment, only a few patient in acute stage because severe arrhythmia, acute heart failure and cardiogenic shock are dead.Some patients can develop into dilated cardiomyopathy.For this reason, be bursting to and develop the needs that more medicines for the treatment of viral myocarditis safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of viral myocarditis disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of viral myocarditis, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Rubi Paicfici 25 parts, Radix Stephaniae Japonicae 18 parts, 20 parts, thunderclap pasture and water, Radix Rhododendri 18 parts, the Radix Astragali 25 parts, Radix Codonopsis 15 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Radix Ophiopogonis 20 parts, Radix Ginseng Rubra 25 parts, Bulbus Lilii 25 parts, Radix Cynanchi Paniculati 20 parts, Rhizoma Acori Graminei 15 parts, Fructus Ligustri Lucidi 18 parts, Medulla Junci 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of viral myocarditis, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of viral myocarditis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment viral myocarditis medicine being used for the treatment of viral myocarditis.
Herba Rubi Paicfici is the herb of rosaceous plant Herba Rubi Paicfici.Herb is used as medicine, and has the effect of heat clearing and blood circulation promoting.
Radix Stephaniae Japonicae is Menispermaceae stephania plant Radix Stephaniae Japonicae StephaniasinicaDiels, is used as medicine with tuber.Heat-clearing and toxic substances removing, eliminating stasis to stop pain.For upper respiratory tract infection, pharyngolaryngitis, stomachache, acute gastroenteritis, bacillary dysentery, malaria, rheumatalgia, trauma pain; Traumatic injury is controlled in external, venom, sore swollen toxin.
Thunderclap pasture and water are the root of the blue Auricled Hedyotis Herb of Commelianaceae plant.Tonify deficiency, dehumidifying, relaxing muscles and tendons and activating QI and blood in the collateral.Control deficiency-heat not move back, oedema due to nephritis, rheumatic arthralgia, eczema.
Radix Rhododendri is Ericaceae rhododendron bright hair Cuculus polioephalus RhododendronmicrophytonFranch., is used as medicine with root.Xia Qiu gathers, and cleans, and section is dried or using fresh herb.Energy clearing away heat and expelling pathogen in the exterior, diuresis.For flu, acute and chronic nephritis, pyelonephritis, infantile convulsion.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science thinks that the pathogenesis of viral myocarditis is deficiency of both QI and YIN, and insufficiency of heart-QI is then agitated unable, blood-vessel obstructive, deficiency of heart-yin then heart arteries and veins is lost foster and causes a disease.Herba Rubi Paicfici of the present invention, Radix Stephaniae Japonicae, thunderclap pasture and water, Radix Rhododendri, the Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae clearing away heat-fire, the double the moon that nourishes heart is for monarch drug, Radix Ophiopogonis, Radix Ginseng Rubra, Bulbus Lilii, Radix Cynanchi Paniculati, Rhizoma Acori Graminei, Fructus Ligustri Lucidi, Medulla Junci nourishing blood and invigorating qi are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, supplementing QI and nourishing YIN, heat-clearing and toxic substances removing, treatment viral myocarditis successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba Rubi Paicfici 25g, Radix Stephaniae Japonicae 18g, thunderclap pasture and water 20g, Radix Rhododendri 18g, Radix Astragali 25g, Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae 20g, Radix Ophiopogonis 20g, Radix Ginseng Rubra 25g, Bulbus Lilii 25g, Radix Cynanchi Paniculati 20g, Rhizoma Acori Graminei 15g, Fructus Ligustri Lucidi 18g, Medulla Junci 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba Rubi Paicfici 25g, Radix Stephaniae Japonicae 18g, thunderclap pasture and water 20g, Radix Rhododendri 18g, Radix Astragali 25g, Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae 20g, Radix Ophiopogonis 20g, Radix Ginseng Rubra 25g, Bulbus Lilii 25g, Radix Cynanchi Paniculati 20g, Rhizoma Acori Graminei 15g, Fructus Ligustri Lucidi 18g, Medulla Junci 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get Herba Rubi Paicfici 25g, Radix Stephaniae Japonicae 18g, thunderclap pasture and water 20g, Radix Rhododendri 18g, Radix Astragali 25g, Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae 20g, Radix Ophiopogonis 20g, Radix Ginseng Rubra 25g, Bulbus Lilii 25g, Radix Cynanchi Paniculati 20g, Rhizoma Acori Graminei 15g, Fructus Ligustri Lucidi 18g, Medulla Junci 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.
4, pharmaceutical preparation treatment viral myocarditis of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation viral myocarditis case 50 example, wherein man 25 example, female 25 example, 18 ~ 46 years old age.
4.2 diagnostic criterias: clinical manifestation has uncomfortable in chest, nervous, arrhythmia or heart failure etc., electrocardiogram have ST-T change and ectopic cardiac rhythm.Or the evidence of the cardiomyopathy such as conduction block.When comprising the evidence of viral infection: heating, diarrhoea or flu-like symptom, occur heart sympton or ECG Change after generation soon; Serum-virus neutralizing antibody measures positive findings; Pharynx, anus virus purification, as the positive has the meaning of auxiliary diagnosis, but its meaning need combine with positive neutralizing antibody measurement result; From feces, serum or cardiac muscular tissue, viral RNA is detected by polymerase chain reaction method; Viral RNA is detected from cardiac muscular tissue.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: clinical symptoms, sign disappear, electrocardiogram, lab testing recover normal; Effective: clinical symptoms, sign disappear substantially, electrocardiogram, lab testing recover normal substantially; Effective: clinical symptoms, sign make moderate progress, electrocardiogram, lab testing indices have some improvement; Invalid: clinical symptoms, sign and electrocardiogram, lab testing are all without improvement.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 25 | 4 | 12 | 8 | 1 | 96 |
| Blank group | 25 | 1 | 2 | 1 | 21 | 16 |
Visible, the medicine that the present invention obtains can safe and effective treatment viral myocarditis, and has no side effect.
4.6 Lee, female, 25 years old, suffers from viral myocarditis, and showing as performance has uncomfortable in chest, nervous, arrhythmia, gives the Chinese medicine that granule embodiment of the present invention provides, and after 1 course for the treatment of, clinical symptoms, sign disappear, and electrocardiogram, lab testing recover normal.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of viral myocarditis, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Rubi Paicfici 25 parts, Radix Stephaniae Japonicae 18 parts, 20 parts, thunderclap pasture and water, Radix Rhododendri 18 parts, the Radix Astragali 25 parts, Radix Codonopsis 15 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Radix Ophiopogonis 20 parts, Radix Ginseng Rubra 25 parts, Bulbus Lilii 25 parts, Radix Cynanchi Paniculati 20 parts, Rhizoma Acori Graminei 15 parts, Fructus Ligustri Lucidi 18 parts, Medulla Junci 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of viral myocarditis as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of viral myocarditis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment viral myocarditis medicine of viral myocarditis according to claim 1.
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| CN201510532104.1A CN105031217A (en) | 2015-08-26 | 2015-08-26 | Pharmaceutical preparation for treating viral myocarditis |
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| CN201510532104.1A CN105031217A (en) | 2015-08-26 | 2015-08-26 | Pharmaceutical preparation for treating viral myocarditis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105582528A (en) * | 2016-02-24 | 2016-05-18 | 薛艳 | Sugar pill for treating pediatric viral myocarditis and preparation method thereof |
| CN105770221A (en) * | 2016-03-30 | 2016-07-20 | 王银法 | Medicine for treating viral myocarditis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105582528A (en) * | 2016-02-24 | 2016-05-18 | 薛艳 | Sugar pill for treating pediatric viral myocarditis and preparation method thereof |
| CN105770221A (en) * | 2016-03-30 | 2016-07-20 | 王银法 | Medicine for treating viral myocarditis |
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Application publication date: 20151111 |