CN105056014A - Medicinal preparation for treating middle-aged and old abdominal distension - Google Patents
Medicinal preparation for treating middle-aged and old abdominal distension Download PDFInfo
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Abstract
The invention belongs to the field of Chinese medicinal preparations, and specifically provides a medicinal preparation for treating middle-aged and old abdominal distension. The medicinal preparation is prepared from the following raw materials: 25 parts of Desmodium microphyllum, 18 parts of sungrass, 15 parts of Lysimachia paridiformais Franch, 25 parts of phellinus igniarius, 28 parts of pseudostellaria heterophylla, 15 parts of bighead atractylodes rhizome, 15 parts of malt, 20 parts of radish seed, 25 parts of hawthorn, 20 parts of medicinal evodia fruit, 25 parts of poria cocos, 20 parts of red paeony root, 15 parts of pinellia tuber, 15 parts of dried orange peel, 15 parts of suberect spatholobus stem, 25 parts of astragalus, 15 parts of officinal magnolia bark and 5 parts of liquoric root. The medicinal preparation can be used for treating middle-aged and old abdominal distension.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind ofly be used for the treatment of pharmaceutical preparation of person in middle and old age's abdominal distention and its preparation method and application.
Background technology
Some gastroenteropathys such as abdominal distention flatulence are all that during we live, more common some are not symptoms.And aging old man, because physical function fails along with the increase at age, the saliva of old man and the secretory volume of gastric juice there will be decline, and this directly results in old people and occurs dyspepsia.Old people, due to digestive function weakness, often there will be abdominal part flatulence, thus cause abdominal distention, stomachache, frequently passwind, the phenomenon such as to have the hiccups, even make people's uneasy in either sitting or lying, not only feel bad but also awkward.To this, the refined yurt in the Japan medical science doctor village is pointed out, " flatulence be ten thousand diseases because of ", healthy very harmful to old man.The stagnation of QI is stayed in body, and various body fluid can be hindered to circulate, and makes internal organs vigor impaired, causes aching and fatigue of each position, causes body immunity to decline, bring out various disease.For this reason, the needs that the medicine developing the more person in middle and old age for the treatment of safely and effectively abdominal distention meets clinical treatment are bursting to.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of person in middle and old age's abdominal distention disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of person in middle and old age's abdominal distention, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba desmodii microphylli 25 parts, 18 parts, red acid bar, large Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 15 parts, Phellinus igniarius (L. ex Fr.) Quel. 25 parts, Radix Pseudostellariae 28 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 15 parts, Fructus Hordei Germinatus, Semen Raphani 20 parts, Fructus Crataegi 25 parts, Fructus Evodiae 20 parts, 25 parts, Poria, Radix Paeoniae Rubra 20 parts, the Rhizoma Pinelliae 15 parts, Pericarpium Citri Reticulatae 15 parts, Caulis Spatholobi 15 parts, the Radix Astragali 25 parts, Cortex Magnoliae Officinalis 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of person in middle and old age's abdominal distention, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of person in middle and old age's abdominal distention, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment person in middle and old age abdominal distention medicine being used for the treatment of person in middle and old age's abdominal distention.
Herba desmodii microphylli is pulse family, beggar-ticks, herbaceos perennial.Be born in the thick grass of wasteland or in spinney.Classification system: Desmodiummicrophyllum (Thunb.) DC. invigorating spleen to remove dampness, relieving cough and asthma, removing toxic substances and promoting subsidence of swelling.For infantile malnutrition, jaundice, dysentery, cough, asthma, bronchitis; Venom is controlled in external, and carbuncle skin ulcer is festered, dermatitis rhus, hemorrhoid.The present invention is with all herbal medicine.
Red acid bar is Polygonaceae arsesmart Herba Polygoni Capitati PoygonumcapitatumBuch.-Ham.ex.D.Don, with all herbal medicine.The whole year can adopt, and cleans, using fresh herb or dry, clearing away heat and cooling blood, diuresis.For urinary system infection, dysentery, diarrhoea, hematuria; Diaper rash is controlled in external, impetigo.
Large Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) is Primulaceae Lysimachia plant Rhizoma Paridis Herba lysimachiae capillipedis LysimachiaparidiformaisFranch., with all herbal medicine.The four seasons can adopt, using fresh herb or dry.Perennial herb, height about 30 centimetres, can reach 60 centimetres.Root stock tubbiness, supporting root is most, elongated, faint yellow.Stem is upright, not branch, and nearly base portion is red, has pubescence, upper green or redly, dipped beam is sliding; Internode is longer, and joint place slightly expands, and has the flakey lobule of degeneration.Leaf is often four, nearly stockless, and wheel is born in stem top, wide ellipse, avette or ovum shape lanceolar.Summer-flowering, spends majority, clusters in stem top; Corolla is yellow, slightly meat.Capsule is spherical, is coated in the calyx deposited place.The chest stuffiness relieving profit diaphragm, eliminates the phlegm, antitussive, pain relieving.For pulmonary tuberculosis, chronic cough, gastroenteritis, stomachache, lumbago due to pathogenic wind-dampness, puerperal abdonimal pain; Traumatic injury, venom are controlled in external, furuncle and phyma.
Phellinus igniarius (L. ex Fr.) Quel., Latin is called Phellinusigniarius (L.exFr.) Qeul., being a kind of fungus, gaining the name because parasitizing mulberry.Sporophore stockless, the flat hemispherical of cap or the shape of a hoof, wooden, shallow liver brown to lead or black.The trunks such as poplar, willow, birch, oak also there is growth.Heat clearing away, YIN nourishing, convergence, hemostasis.Control bleeding not during menses, stranguria with blood, proctoptosis rushes down blood, married woman strains, scrofula festers, lumps in the chest and abdomen, diarrhea due to hypofunction of the spleen.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science is thought; person in middle and old age's abdominal distention mostly is stagnation of QI due to depression of the liver; weakness of the spleen and stomach is done, and Herba desmodii microphylli of the present invention, red acid bar, large Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Phellinus igniarius (L. ex Fr.) Quel., Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Fructus Hordei Germinatus, Semen Raphani depressed liver-energy dispersing and QI regulating are monarch drug, Fructus Crataegi, Fructus Evodiae, Poria, Radix Paeoniae Rubra, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Caulis Spatholobi, the Radix Astragali, Cortex Magnoliae Officinalis air making-up and spleen enlivening; ascending the clear and descending the turbid is ministerial drug; Radix Glycyrrhizae is adjuvant, full side compatibility mutually, depressed liver-energy dispersing and QI regulating, air making-up and spleen enlivening; ascending the clear and descending the turbid, treatment person in middle and old age abdominal distention successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba desmodii microphylli 25g, red acid bar 18g, large Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 15g, Phellinus igniarius (L. ex Fr.) Quel. 25g, Radix Pseudostellariae 28g, Rhizoma Atractylodis Macrocephalae 15g, Fructus Hordei Germinatus 15g, Semen Raphani 20g, Fructus Crataegi 25g, Fructus Evodiae 20g, Poria 25g, Radix Paeoniae Rubra 20g, Rhizoma Pinelliae 15g, Pericarpium Citri Reticulatae 15g, Caulis Spatholobi 15g, Radix Astragali 25g, Cortex Magnoliae Officinalis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba desmodii microphylli 25g, red acid bar 18g, large Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 15g, Phellinus igniarius (L. ex Fr.) Quel. 25g, Radix Pseudostellariae 28g, Rhizoma Atractylodis Macrocephalae 15g, Fructus Hordei Germinatus 15g, Semen Raphani 20g, Fructus Crataegi 25g, Fructus Evodiae 20g, Poria 25g, Radix Paeoniae Rubra 20g, Rhizoma Pinelliae 15g, Pericarpium Citri Reticulatae 15g, Caulis Spatholobi 15g, Radix Astragali 25g, Cortex Magnoliae Officinalis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Herba desmodii microphylli 25g, red acid bar 18g, large Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 15g, Phellinus igniarius (L. ex Fr.) Quel. 25g, Radix Pseudostellariae 28g, Rhizoma Atractylodis Macrocephalae 15g, Fructus Hordei Germinatus 15g, Semen Raphani 20g, Fructus Crataegi 25g, Fructus Evodiae 20g, Poria 25g, Radix Paeoniae Rubra 20g, Rhizoma Pinelliae 15g, Pericarpium Citri Reticulatae 15g, Caulis Spatholobi 15g, Radix Astragali 25g, Cortex Magnoliae Officinalis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment person in middle and old age abdominal distention of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation person in middle and old age abdominal distention case 70 example, 55 ~ 68 years old age.The shortest person of the course of disease 4 months, most elder reaches 1 year.
4.2 diagnostic criterias: abdominal distention, constipation, stomachache companion feel sick, and vomiting, aerofluxus is many.Flatulence all has abdominal tympanites in general, the bulge being confined to epigastrium is more common in caused by stomach or transverse colon pneumatosis, little intestinal gas abdominal tympanites can be confined to midriff, also can be full abdominal tympanites, aerocoly abdominal tympanites can be confined to hypogastric region or left lower abdomen, during pyloric obstruction, epigastrium can have gastric pattern and peristalsis, visible visible peristalsis visible intestinal peristalsis and peristaltic wave during intestinal obstruction, bowel sound hyperaction or weaken, peritonitis patient can have tenderness and muscle tonus.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: symptom all disappears; Effective: symptom obviously alleviates; Invalid: without significant change or deterioration before and after treatment.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 35 | 14 | 18 | 3 | 91.4 |
| Blank group | 35 | 1 | 1 | 33 | 6.1 |
Visible, the medicine that the present invention obtains can safe and effective treatment person in middle and old age abdominal distention, and have no side effect.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of person in middle and old age's abdominal distention; it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba desmodii microphylli 25 parts, 18 parts, red acid bar, large Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 15 parts, Phellinus igniarius (L. ex Fr.) Quel. 25 parts, Radix Pseudostellariae 28 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 15 parts, Fructus Hordei Germinatus, Semen Raphani 20 parts, Fructus Crataegi 25 parts, Fructus Evodiae 20 parts, 25 parts, Poria, Radix Paeoniae Rubra 20 parts, the Rhizoma Pinelliae 15 parts, Pericarpium Citri Reticulatae 15 parts, Caulis Spatholobi 15 parts, the Radix Astragali 25 parts, Cortex Magnoliae Officinalis 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of person in middle and old age's abdominal distention as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of person in middle and old age's abdominal distention as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. the application of the pharmaceutical preparation being used for the treatment of person in middle and old age's abdominal distention according to claim 1 in the treatment in old abdominal distention medicine.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107495052A (en) * | 2017-08-17 | 2017-12-22 | 武汉华士特工业生物技术开发有限公司 | A kind of solid beverage composition and preparation method thereof of function of spleen and stomach regulating discord, abdominal fullness and distention |
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| KR20140095169A (en) * | 2013-01-23 | 2014-08-01 | 주식회사 휴온스 | Solid oral formulation comprising viscous extract of Magnolia cortex |
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| KR20140095169A (en) * | 2013-01-23 | 2014-08-01 | 주식회사 휴온스 | Solid oral formulation comprising viscous extract of Magnolia cortex |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107495052A (en) * | 2017-08-17 | 2017-12-22 | 武汉华士特工业生物技术开发有限公司 | A kind of solid beverage composition and preparation method thereof of function of spleen and stomach regulating discord, abdominal fullness and distention |
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Application publication date: 20151118 |