CN104998170A

CN104998170A - Medicinal preparation for treating astriction

Info

Publication number: CN104998170A
Application number: CN201510493822.2A
Authority: CN
Inventors: ***
Original assignee: QINGDAO QINCHENG MEDICINE TECHNOLOGY Co Ltd
Current assignee: QINGDAO QINCHENG MEDICINE TECHNOLOGY Co Ltd
Priority date: 2015-08-12
Filing date: 2015-08-12
Publication date: 2015-10-28

Abstract

The invention belongs to the field of traditional Chinese medicine preparation and particularly discloses a medicinal preparation for treating astriction. The medicinal preparation is prepared from the following traditional Chinese medicines in parts by weight through extraction: 9 parts of radix bupleuri, 6 parts of cinnamon, 15 parts of rhizoma atractylodis macrocephalae, 6 parts of liquorice, 15 parts of eucommia ulmoides, 30 parts of oyster, 10 parts of ligusticum wallichii, 15 parts of rheum officinale, 30 parts of astragalus membranaceus, 40 parts of fossil fragments, 15 parts of codonopsis pilosula, 15 parts of dogwood, 15 parts of fructus alpiniae oxyphyllae and 20 parts of cortex phellodendri. The medicinal preparation has an obvious effect for treating astriction.

Description

A kind of pharmaceutical preparation for the treatment of constipation

Technical field

The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of pharmaceutical preparation for the treatment of constipation.

Background technology

Constipation is a kind of commonly encountered diseases, defecates dry and hard for a long time, within many days, defecates once, and each solution just difficulty is painful, and of a specified duration easily causes Other diseases.The product effect of current treatment constipation is all not so good, is therefore badly in need of a kind of Chinese medicine for the treatment of constipation.

Summary of the invention

Goal of the invention: the object of the present invention is to provide a kind of pharmaceutical preparation and application thereof for the treatment of constipation.

Technical scheme:

Treat a pharmaceutical preparation for constipation, be prepared from by the Chinese medicine extraction of following weight portion: Radix Bupleuri 9 parts, Cortex Cinnamomi 6 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 6 parts, Radix Glycyrrhizae, the Cortex Eucommiae 15 parts, Concha Ostreae 30 parts, Rhizoma Chuanxiong 10 parts, Radix Et Rhizoma Rhei 15 parts, the Radix Astragali 30 parts, Os Draconis 40 parts, Radix Codonopsis 15 parts, Fructus Corni 15 parts, Fructus Alpiniae Oxyphyllae 15 parts, Cortex Phellodendri 20 parts.

The pharmaceutical preparation of described treatment constipation, preparation method is: above Chinese medicine, decocts with water 2 times, adds the soak by water 2 hours of medical material weight 10 times amount at every turn, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.2, obtains extractum, spraying dry, pulverize, cross 100 mesh sieves, add adjuvant, make pharmaceutical preparation.

The application of pharmaceutical preparation in preparation treatment constipation medicine of described treatment constipation.

Beneficial effect: the traditional Chinese medical science thinks that the cause of disease of constipation has that dryness-heat stagnating in the interior, deficiency of body fluid, feelings will are become estranged, depression and stagnation of QI, and overstrain internal injury, health are weak, insufficiency of vital energy and blood etc., cause large intestine conduction function not normal, and cause constipation.Pathological change is the voxel excess of YANG, accumulated heat in gastrointestinal tract, so that body fluid being damaged, and intestinal loses profit, so constipation with dry stool, is difficult to discharge; Be worried excessively, feelings will is not relaxed, or sitting is moved less, often causes depression and stagnation of QI, can not declare and reach, and falls not normal so logical, and conduction dereliction of duty, stops in waste matter, must not be descending; Overstrain internal injury or after being ill, puerperal, aged debility people, deficiency of both QI and blood, the deficiency of vital energy then large intestine transmits unable, and then Tianjin is withered can not moisten large intestine for blood deficiency, even undermines part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels essence and blood, so that this yuan is by losing, and Kidney-Yin one loses, and intestinal loses profit and more capable dry withered; Kidney-Yang one loses, then can not evaporate body fluid, gentle intestinal, all makes stool discharge difficulty, constipated obstructed.In addition, yang deficiency is weak, and raw in YIN-cold, stay in the intestines and stomach, so yang-energy is obstructed, body fluid is not all right, therefore intestinal is difficult in transmission, thus causes constipation.Therefore in the present invention, Radix Bupleuri, Cortex Cinnamomi, Rhizoma Atractylodis Macrocephalae promoting the circulation of QI to relieve pain are monarch drug, the Cortex Eucommiae, Concha Ostreae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, the Radix Astragali, Os Draconis, Radix Codonopsis, Fructus Corni, Fructus Alpiniae Oxyphyllae, Cortex Phellodendri dispelling cold by warming the meridian, heat-clearing and toxic substances removing is ministerial drug, and Radix Glycyrrhizae is adjuvant, full side treats constipation, respond well.

Detailed description of the invention

Embodiment 1: get Radix Bupleuri 9g, Cortex Cinnamomi 6g, Rhizoma Atractylodis Macrocephalae 15g, Radix Glycyrrhizae 6g, Cortex Eucommiae 15g, Concha Ostreae 30g, Rhizoma Chuanxiong 10g, Radix Et Rhizoma Rhei 15g, Radix Astragali 30g, Os Draconis 40g, Radix Codonopsis 15g, Fructus Corni 15g, Fructus Alpiniae Oxyphyllae 15g, Cortex Phellodendri 20g, above Chinese medicine, decoct with water 2 times, add the soak by water 2 hours of medical material weight 10 times amount at every turn, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.2, obtains extractum, spraying dry, pulverize, cross 100 mesh sieves, add starch 50g, tabletting, makes tablet.

Embodiment 2: get Radix Bupleuri 9g, Cortex Cinnamomi 6g, Rhizoma Atractylodis Macrocephalae 15g, Radix Glycyrrhizae 6g, Cortex Eucommiae 15g, Concha Ostreae 30g, Rhizoma Chuanxiong 10g, Radix Et Rhizoma Rhei 15g, Radix Astragali 30g, Os Draconis 40g, Radix Codonopsis 15g, Fructus Corni 15g, Fructus Alpiniae Oxyphyllae 15g, Cortex Phellodendri 20g, above Chinese medicine, decoct with water 2 times, add the soak by water 2 hours of medical material weight 10 times amount at every turn, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.2, obtains extractum, spraying dry, pulverize, cross 100 mesh sieves, add starch 50g, encapsulating capsule, makes capsule.

Embodiment 3: get Radix Bupleuri 9g, Cortex Cinnamomi 6g, Rhizoma Atractylodis Macrocephalae 15g, Radix Glycyrrhizae 6g, Cortex Eucommiae 15g, Concha Ostreae 30g, Rhizoma Chuanxiong 10g, Radix Et Rhizoma Rhei 15g, Radix Astragali 30g, Os Draconis 40g, Radix Codonopsis 15g, Fructus Corni 15g, Fructus Alpiniae Oxyphyllae 15g, Cortex Phellodendri 20g, above Chinese medicine, decocts with water 2 times, adds the soak by water 2 hours of medical material weight 10 times amount at every turn, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.2, obtains extractum, spraying dry, pulverize, cross 100 mesh sieves, add dextrin 50g, make granule.

Embodiment 4: the present invention is on the impact of mice with constipation Small intestine advance activity

Animal, medicine, reagent: animal: healthy ICR mice, male and female half and half, heavy 18-22g, is provided by Shanghai Slac Experimental Animal Co., Ltd., production licence number SCXK (Shanghai) 2013-0003.Pharmaceutical preparation of the present invention is prepared by above-described embodiment 3; R-1132, Wujin pharmaceutical factory, 20140613.Phenolphthalein tablets (phenolphthalein sugar-tablet), Junan, Shandong Province pharmaceutical factory, specification: 100mg*100 sheet/box, lot number 20140521

Experimentation: get ICR mice 60, with the modeling of R-1132 50m/kg gavage, continuous 10 days, period normal diet, form Constipation Model, random packet, often organize about 10, male and female half and half, be divided into normal group, model group, positive drug group (giving phenolphthalein tablets), pharmaceutical preparation of the present invention is high, in, low three dosage groups, administration is the same, successive administration 14d, before experiment, water 12h is can't help in fasting, 2h after last administration, gavage with the charcoal end arabic gum suspension lml/g that volume fraction is 5% respectively, each group of mice is put to death after 20min, cut open the belly and measure every Mus small intestinal charcoal end displacement and total small intestinal length, be converted into the percentage rate that charcoal end displacement accounts for total small intestinal length, t test and judge group difference, the results are shown in Table 1.

Table 1 the present invention is on the impact (n=10) of mice with constipation Small intestine advance activity

Compare with model group, * * P<0.01 * P<0.05, compares with positive drug group, ##P<0.01 #P<0.05

Result: pharmaceutical preparation of the present invention is compared with model group, have and obviously promote mice with constipation Small intestine advance activity, promote gastrointestinal motility in mice, there is significant difference, compare with positive drug, pharmaceutical preparation senior middle school of the present invention dosage group has significant difference in promotion mice with constipation Small intestine advance activity, and effect is better than positive drug, illustrates that it has the effect for the treatment of constipation.

Claims

1. treat the pharmaceutical preparation of constipation for one kind, it is characterized in that, be prepared from by the Chinese medicine extraction of following weight portion: Radix Bupleuri 9 parts, Cortex Cinnamomi 6 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 6 parts, Radix Glycyrrhizae, the Cortex Eucommiae 15 parts, Concha Ostreae 30 parts, Rhizoma Chuanxiong 10 parts, Radix Et Rhizoma Rhei 15 parts, the Radix Astragali 30 parts, Os Draconis 40 parts, Radix Codonopsis 15 parts, Fructus Corni 15 parts, Fructus Alpiniae Oxyphyllae 15 parts, Cortex Phellodendri 20 parts.

2. treat the pharmaceutical preparation of constipation as claimed in claim 1, it is characterized in that, preparation method is: above Chinese medicine, decoct with water 2 times, add the soak by water 2 hours of medical material weight 10 times amount, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.2 at every turn, obtain extractum, spraying dry, pulverizes, and crosses 100 mesh sieves, add adjuvant, be prepared into pharmaceutical preparation.

3. treat the application of pharmaceutical preparation in treatment constipation medicine of constipation as claimed in claim 1.