CN103495070A - Navel-applied agent for treating bowel dysfunction after abdominal surgery - Google Patents
Navel-applied agent for treating bowel dysfunction after abdominal surgery Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treating bowel dysfunction after an abdominal surgery in order to solve the treatment problem of the bowel dysfunction after the abdominal surgery. The navel-applied agent is characterized by comprising raw materials including, by weight, aspongopus chinensis dallas, alyxia, timonius arboreus, jasminum grandiflorum, caryopteris terniflora maxim, allium victorialis, gastrodia elata bl, spatholobus suberectus dunn, securinega suffruticosa, azurite, cinnamomum cassia presl and setaria italica beauv. Clinical trials prove that the pharmaceutical composition has the advantages of good curative effect on bowel dysfunction, high security, and being worthy of clinical application and promotion.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of deposited umbilicus agent for the treatment of the abdominal postoperative bowel dysfunction.
Background technology
Bowel dysfunction, be one group and comprise and continuing or intermittently outbreak, and take stomachache, abdominal distention, bowl evacuation habit and stool character is the bowel dysfunction disease of clinical manifestation extremely.The bowel dysfunction that abdominal postoperative occurs is divided into paralytic disorder and spastic disorder according to symptom, acute diffuse peritonitis is more common in the paralytic disorder, lose the wriggling ability because the intestinal wall muscular movement is suppressed after retroperitoneal hamorrhage or infection, the enteric cavity content can not move downwards; And spastic disorder is often due to wound or inflammation being arranged inside and outside enteric cavity, the stimulation such as foreign body and cause intestinal wall muscle and split by force contraction.
The bowel dysfunction that abdominal postoperative occurs is different from intestinal neurosis, the latter claims again irritable bowel syndrome, be that individual body constitution accounts for leading a kind of disease, the bowel dysfunction that abdominal postoperative occurs is clearly relevant to abdominal operation, clearly relevant to the intestinal environmental stimuli.
The many paralysis of bowel dysfunction performance and the spasm that due to abdominal postoperative, occur replace outbreak, so there is no clinically now effective treatment means, only have that report is postoperative places at intraperitoneal the generation that carboxymethyl cellulose (Sodium carboxymethyl cellulose) and oral vitamin E can reduce intestinal adhesion.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the deposited umbilicus agent of the treatment abdominal postoperative bowel dysfunction that side effect is little.
The technical scheme that the present invention solves its technical problem is: a kind of deposited umbilicus agent for the treatment of the abdominal postoperative bowel dysfunction is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Aspongopuss, 6 ~ 12 parts of Herba Alyxiae Sinensiss, alizarin 3 ~ 10 parts of sea, 6 ~ 12 parts of Flos jasmini, 3 ~ 10 parts of Herba Caryopteridis Ternifloraes, 6 ~ 12 parts of Bulbus Allii Victorialis, go back 6 ~ 12 parts, bobbin, 6 ~ 12 parts of nine layers of wind, 6 ~ 12 parts of Cacumen Securinegae Suffruticosaes, 1 ~ 5 part of Azuritum, 3 ~ 10 parts of Ramulus Cinnamomi, 10 ~ 25 parts of Fructus Setariae Germinatus (parched to brown).
Chinese medicine of the present invention is that the raw material by following optimum weight part proportioning is prepared from: 20 parts of Aspongopuss, 10 parts of Herba Alyxiae Sinensiss, alizarin 6 parts of sea, 10 parts of Flos jasmini, 6 parts of Herba Caryopteridis Ternifloraes, 10 parts of Bulbus Allii Victorialis, go back 10 parts, bobbin, 10 parts of nine layers of wind, 10 parts of Cacumen Securinegae Suffruticosaes, 2 parts of Azuritum, 6 parts of Ramulus Cinnamomi, 20 parts of Fructus Setariae Germinatus (parched to brown).
Wherein said: Aspongopus is the dry body of Pentatomidae Insects Aspongopus Aspongopus chinensis Dallas.Nature and flavor are salty, temperature.Return the liver,spleen,kidney warp.But the merit regulating QI to relieve pain, warming middle-JIAO is supporing yang.
Herba Alyxiae Sinensis is herb and the root of apocynaceae plant chain pearl rattan.Toil, flat.Enter lung, liver, spleen three warps.But the merit expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral.
Hai Qian is Sargassaceae plant Alga Sgrgassi Enerves Sargassum enerve C.Ag., Heng Shi Alga Sgrgassi Enerves Sargassum henslowianum C.Ag., sargassum thunbergii Sargassum thunbergii(Mert.) O.Kuntze or Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) argassum horneri(Turn.) frond of C. Ag.Nature and flavor are salty; Cold.Return liver; Stomach; Kidney channel.But merit hard masses softening and resolving; Removing heat-phlegm.
Flos jasmini is Oleaceae plants Flos jasmini Jasminu, the dry flower of grandiflorum L..The property mildly bitter flavor; Property is put down.Return Liver Channel.But the merit soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain.
Herba Caryopteridis Terniflorae, for Verenaceae Caryopteris plants three flower Herba caryopteridis nepetaefoliae Caryopteris terniflora Maxim., with all herbal medicine.The hot micro-hardship of nature and flavor; Flat.Return lung meridian.But merit dispelling wind to relieve the exterior syndrome; The lung qi dispersing cough-relieving.
Bulbus Allii Victorialis is the bulb of liliaceous plant Bulbus Allii Victorialis Allium victorialis L..Return lung meridian.But merit dissipating blood stasis; Hemostasis; Removing toxic substances.
Also bobbin, be the fruit of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Sweet in the mouth; Cold in nature.But merit tonify deficiency subduing the wind syndrome.
Nine layers of wind are the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn.Nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Merit can be enriched blood, invigorates blood circulation, and dredging collateral.
Cacumen Securinegae Suffruticosae is euphorbia plant Suffrutescent Securinega Twig Securinega suffruticosa(Pal1.) browse or the root of Rehd..Acrid in the mouth; Bitter; Slightly warm in nature.Return liver; Kidney; Spleen channel.But merit expelling wind and activating blood circulation; The strong muscle of kidney tonifying.
Azuritum is the Ore of carbonate mineral chessy copper Azurite.Nature and flavor acid; Salty; Flat; Return Liver Channel.But merit vomiting wind-phlegm by emesis; Improving eyesight; Removing toxic substances.
Ramulus Cinnamomi is the withe of canella Cortex Cinnamomi Cinnamomum cassia Presl.The nature and flavor acrid, sweet, warm.Enter the heart, lung, urinary bladder channel.But the merit relieving the exterior syndrome by diaphoresis, promoting the flow of QI-blood by warming the meridian, activating YANG and prormoting functioning of QI.
Fructus Setariae Germinatus (parched to brown),, fry to burnt brown according to frying method through the drying of germinateing for the mature fruit of grass foxtail millet Setaria italica (L.) Beauv..Nature and flavor are sweet, temperature.Return spleen, stomach warp.Merit can help digestion and in, spleen benefiting and stimulating the appetite.
Compared with prior art, the present invention has following characteristics.
1, argument is unique: from dredging collateral, start with, the recovery intestinal wall function of nervous system reparation of take is purpose, avoids using the purgatives medicine thing, although, because the purgatives medicine thing can solve abdominal distention for the moment, intestinal wall has been caused again to new stimulation, gives birth to for a long time his change, protracted course of disease.
2, take Aspongopus, Herba Alyxiae Sinensis is monarch: inventor's clinical experience gained, bowel dysfunction is a kind of reflexive performance after art midgut wall nerve is upset, and the Aspongopus regulating QI to relieve pain, the Herba Alyxiae Sinensis promoting blood circulation to remove obstruction in the collateral, can reduce this zest and reflect the untoward reaction brought to intestinal.The Basic pharmacology test confirms: Partial small bowel obstruction rat model Aspongopus (20g crude drug/kg/d) and Herba Alyxiae Sinensis (10g crude drug/kg/d) mixing water decocting liquid gavage, can reduce intestinal mucosa injury, incomplete intestinal obstruction Intestinal Mucosa is had to protective effect; And observing by charcoal end method the progradation that rat intestine is wriggled, propelling rate (84.42 ± 13.24) % of Aspongopus, Herba Alyxiae Sinensis drug combination group is apparently higher than blank group of (59.33 ± 15.62) %.
3, with the alizarin hard masses softening and resolving in sea, Herba Caryopteridis Terniflorae pungent drugs can disperse and bitter drugs can descend, digestion visible phlegm; Cacumen Securinegae Suffruticosae expelling wind and activating blood circulation, the strong muscle of kidney tonifying; The Flos jasmini promoting the circulation of QI to relieve pain; The Bulbus Allii Victorialis dissipating blood stasis; Nine layers of wind is enriched blood, is invigorated blood circulation, dredging collateral; Azuritum is assisted monarch drug as ministerial drug: breath does not reach, and of a specified duration can block by accumulation of phlegm, so select Herba Caryopteridis Terniflorae, Hai Qian, Azuritum to remove the visible phlegm in the intestinal venation, Flos jasmini, Cacumen Securinegae Suffruticosae, nine layers of wind increase the ability of medicines walking venations.The Azuritum master is containing basic copper carbonate [2CuCO3Cu (OH) 2], and local absorption stimulates the colonic fluid secretion.
4, except going back the righting of bobbin tonify deficiency subduing the wind syndrome, Cacumen Securinegae Suffruticosae, nine layers of wind are the medicine of reinforcement and elimination in combination, and Bulbus Allii Victorialis has the advantages that dissipating blood stasis does not consume gas, are particularly suitable for abdominal postoperative simulataneous insufficiency and excessive and use.
5, low dose of Ramulus Cinnamomi is corrigent, resists the anxiety that this prescription invasion by pathogenic cold medicine of a cold nature thing too much has consumption impairment of QI the moon, and the effect of its activating YANG and prormoting functioning of QI also echoes with Aspongopus, contributes to row loose.
6, Fructus Setariae Germinatus (parched to brown) is sweet in flavor and warm in property, returns the taste warp, get and protect the meaning of sun in defending, and contained coking composition has astriction, and the meaning of receipts is arranged in loose.
7, the thing homogeneous medicine multiple-effect of getting it filled in the side, contribute to reduce medicament categories and consumption, do not increase the Liver and kidney burden.
8, medicine material consumption of the present invention is groped in a large number to sum up through the inventor and is drawn, each raw material consumption is for all to have curative effect preferably in the following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: 20 parts of Aspongopuss, 10 parts of Herba Alyxiae Sinensiss, alizarin 6 parts of sea, 10 parts of Flos jasmini, 6 parts of Herba Caryopteridis Ternifloraes, 10 parts of Bulbus Allii Victorialis, go back 10 parts, bobbin, 10 parts of nine layers of wind, 10 parts of Cacumen Securinegae Suffruticosaes, 2 parts of Azuritum, 6 parts of Ramulus Cinnamomi, 20 parts of Fructus Setariae Germinatus (parched to brown).
The preparation method of embodiment 1 is: by Aspongopus, Herba Alyxiae Sinensis, Hai Qian, Flos jasmini, Herba Caryopteridis Terniflorae, Bulbus Allii Victorialis, go back bobbin, nine layers of wind, Cacumen Securinegae Suffruticosae, Azuritum, Ramulus Cinnamomi, Fructus Setariae Germinatus (parched to brown) mixing and water addings and decoct, get filtrate after 30 minutes, medicinal residues add water continuation decoction and get filtrate after 20 minutes, twice filtrate merges, and is divided into two parts of morning and evenings to take.
Embodiment 2, the crude drug weight proportion: 10 parts of Aspongopuss, 6 parts of Herba Alyxiae Sinensiss, alizarin 3 parts of sea, 6 parts of Flos jasmini, 3 parts of Herba Caryopteridis Ternifloraes, 6 parts of Bulbus Allii Victorialis, go back 6 parts, bobbin, 6 parts of nine layers of wind, 6 parts of Cacumen Securinegae Suffruticosaes, 1 part of Azuritum, 3 parts of Ramulus Cinnamomi, 10 parts of Fructus Setariae Germinatus (parched to brown).
Embodiment 3, the crude drug weight proportion: 20 parts of Aspongopuss, 10 parts of Herba Alyxiae Sinensiss, alizarin 6 parts of sea, 10 parts of Flos jasmini, 6 parts of Herba Caryopteridis Ternifloraes, 10 parts of Bulbus Allii Victorialis, go back 10 parts, bobbin, 10 parts of nine layers of wind, 10 parts of Cacumen Securinegae Suffruticosaes, 2 parts of Azuritum, 6 parts of Ramulus Cinnamomi, 20 parts of Fructus Setariae Germinatus (parched to brown).
Embodiment 4, the crude drug weight proportion: 30 parts of Aspongopuss, 12 parts of Herba Alyxiae Sinensiss, alizarin 10 parts of sea, 12 parts of Flos jasmini, 10 parts of Herba Caryopteridis Ternifloraes, 12 parts of Bulbus Allii Victorialis, go back 12 parts, bobbin, 12 parts of nine layers of wind, 12 parts of Cacumen Securinegae Suffruticosaes, 5 parts of Azuritum, 10 parts of Ramulus Cinnamomi, 25 parts of Fructus Setariae Germinatus (parched to brown).
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) will go back bobbin, Herba Alyxiae Sinensis, Herba Caryopteridis Terniflorae coarse powder and soak separately after 4 hours and extract volatile oil 6 hours with vapor distillation, and mixing for standby use after collecting, medicinal residues are standby;
(2) Azuritum, Fructus Setariae Germinatus (parched to brown) were pulverized to 150 mesh sieves, and became fine powder standby;
(3) gained medicinal residues in Aspongopus, Hai Qian, Flos jasmini, Bulbus Allii Victorialis, nine layers of wind, Cacumen Securinegae Suffruticosae, Ramulus Cinnamomi and step 1 are mixed with 5 times of amount 80% ethanol extractions 2 times, each 2 hours, merge ethanol extract twice, filter the extractum that when recovery ethanol concentrating under reduced pressure become 60 ℃, relative density is 1.25～1.30;
(4) add gained extractum in step 3 to mix gained fine powder in step 2,60 ℃ of oven dry, be ground into fine powder, adds the Tween-80 granulation, dries, and granulate, spray into gained volatile oil in step 1, mixes packing and get final product.
Effective combination of said medicine, coordinate mutually, effectively reach the purpose for the treatment of abdominal postoperative bowel dysfunction, and side effect is less.The above results is the clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case is selected: case is selected from case 76 examples that in June, 2011 ~ 2013 year JIUYUE is diagnosed as the abdominal postoperative bowel dysfunction.Abdominal surgery 37 examples wherein, obstetrics and gynecology operation 39 examples.
1.1.2 abdominal postoperative bowel dysfunction diagnostic criteria:
(1) abdominal postoperative occurred in 10 days, and the persistent period was over 30 days;
(2) accompany by 2 kinds in lower 3 kinds of situations, but without continuously: 1. after defecation, alleviate; 2. the defecation frequency changes (> 3/d or 3<week during onset of disease); 3. onset of disease time companion feces character changes.
1.1.3 be divided at random three groups: matched group 25 examples, decoction group 25 examples, apply umbilicus group 26 examples.Before three groups of patient treatments, on sex, age, Operative category, compare, and the difference not statistically significant (P > 0.05), there is comparability.
1.2 method.
1.2.1 Therapeutic Method: matched group is taked respectively symptomatic treatment according to constipation or diarrhoea situation, and the decoction group is used embodiment 1 gained decoction, 2 times/d; Apply the umbilicus group and adopt the deposited umbilicus granule vinegar of described embodiment 3 gained to dress umbilicus, 2 times/d, be total to 14d.
1.2.2 observation index: to main clinic symptoms (feel sick, vomiting, abdominal distention, stomachache, diarrhoea or constipation), before treatment, after treatment, after 14d, drug withdrawal, 30d is marked according to Self-reporting inventory, nothing: be 0 minute without this symptom; Slightly: conscious have this symptom, but do not take place frequently, and not serious is 1 minute; Moderate: conscious have this symptom, between light, heavier, is 2 minutes; Heavier: significantly this symptom is arranged, between in, between severe, be 3 minutes; Severe: the frequency of conscious this symptom and intensity are all 4 minutes very strongly.
1.2.3 criterion of therapeutical effect: symptom total points * 100% before therapeutic index (%)=(symptom total points after symptom total points before treatment-treatment)/treatment.Judge curative effect by therapeutic index, produce effects: therapeutic index > 76%; Effectively: therapeutic index is 51% ~ 75%; Take a turn for the better: therapeutic index is 26% ~ 50%; Invalid: therapeutic index<25%.
1.2.4 recurrence standard: symptom total points * 100% after recurrence index (%)=(the rear symptom total points of 30d symptom total points-treatment after drug withdrawal)/treatment.The recurrence index > 50% item be judged as recurrence.
1.2.5 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data is checked with t, enumeration data χ
2check.
2 results.
2.1 three groups of Clinical efficacy comparisons: see the following form.Result shows: the total effective rate of decoction group and deposited umbilicus group is apparently higher than matched group (P<0.05).
| Group | Number of cases | Produce effects | Effectively | Take a turn for the better | Invalid | Total effective rate |
| Matched group | 25 | 6（8.00%） | 9（36.00%） | 3（12.00%） | 7（28.00%） | 72.00% |
| The decoction group | 25 | 13（52.00%） | 7（28.00%） | 4（16.00%） | 1（4.00%） | 96.00% |
| Apply the umbilicus group | 26 | 11（42.31%） | 9（34.62%） | 4（15.38%） | 2（7.69%） | 92.31% |
2.2 recurrence appears in patient relapse rate in three groups of half days of patient: 38.89%(7/18 is arranged during the effective patient 30d for the treatment of of control group), the decoction group is 4.17%(1/24), applying the umbilicus group is 8.33%(1/24), the relapse rate of decoction group and deposited umbilicus group all is starkly lower than matched group (P<0.01).
2.3 three groups of adverse reactions of patients incidence rates relatively: three groups the obvious adverse reaction record all do not occur.
3. conclusion.
This result of study shows, after taking decoction of the present invention or deposited umbilicus, abdominal postoperative bowel dysfunction patient cure rate, total effective rate are apparently higher than matched group, and relapse rate is starkly lower than matched group, the obvious adverse reaction record do not occur, illustrate that pharmaceutical composition of the present invention is having good effect, the lighter advantage of untoward reaction aspect treatment abdominal postoperative bowel dysfunction.
Claims (2)
1. a pharmaceutical composition for the treatment of the abdominal postoperative bowel dysfunction is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Aspongopuss, 6 ~ 12 parts of Herba Alyxiae Sinensiss, alizarin 3 ~ 10 parts of sea, 6 ~ 12 parts of Flos jasmini, 3 ~ 10 parts of Herba Caryopteridis Ternifloraes, 6 ~ 12 parts of Bulbus Allii Victorialis, go back 6 ~ 12 parts, bobbin, 6 ~ 12 parts of nine layers of wind, 6 ~ 12 parts of Cacumen Securinegae Suffruticosaes, 1 ~ 5 part of Azuritum, 3 ~ 10 parts of Ramulus Cinnamomi, 10 ~ 25 parts of Fructus Setariae Germinatus (parched to brown).
2. a kind of pharmaceutical composition for the treatment of the abdominal postoperative bowel dysfunction according to claim 1 is characterized in that being prepared from by the crude drug of following weight proportion: 20 parts of Aspongopuss, 10 parts of Herba Alyxiae Sinensiss, alizarin 6 parts of sea, 10 parts of Flos jasmini, 6 parts of Herba Caryopteridis Ternifloraes, 10 parts of Bulbus Allii Victorialis, go back 10 parts, bobbin, 10 parts of 99 layers of wind, 10 parts of Cacumen Securinegae Suffruticosaes, 2 parts of Azuritum, 6 parts of Ramulus Cinnamomi, 20 parts of Fructus Setariae Germinatus (parched to brown).
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103721073A (en) * | 2014-01-13 | 2014-04-16 | 威海市妇女儿童医院 | Pessary for prenatal care and preparation method thereof |
| CN113956369A (en) * | 2021-10-21 | 2022-01-21 | 河南省医药科学研究院 | Preparation method and application of Caryopteris clandonensis polysaccharide |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804173A (en) * | 2010-05-28 | 2010-08-18 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating dyspepsia and preparation method thereof |
| CN101804172A (en) * | 2010-05-28 | 2010-08-18 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating anorexia and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804173A (en) * | 2010-05-28 | 2010-08-18 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating dyspepsia and preparation method thereof |
| CN101804172A (en) * | 2010-05-28 | 2010-08-18 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating anorexia and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103721073A (en) * | 2014-01-13 | 2014-04-16 | 威海市妇女儿童医院 | Pessary for prenatal care and preparation method thereof |
| CN103721073B (en) * | 2014-01-13 | 2015-11-04 | 威海市妇女儿童医院 | Pessary for prenatal care and preparation method thereof |
| CN113956369A (en) * | 2021-10-21 | 2022-01-21 | 河南省医药科学研究院 | Preparation method and application of Caryopteris clandonensis polysaccharide |
| CN113956369B (en) * | 2021-10-21 | 2022-09-27 | 河南省医药科学研究院 | Preparation method and application of Caryopteris clandonensis polysaccharide |
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