CN102688379B

CN102688379B - Chinese herbal medicine pill for treating constipation

Info

Publication number: CN102688379B
Application number: CN2012101830617A
Authority: CN
Inventors: 李珍华; 张西菊
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-05-31
Filing date: 2012-05-31
Publication date: 2013-12-25
Anticipated expiration: 2032-05-31
Also published as: CN102688379A

Abstract

The invention discloses a Chinese herbal medicine pill for treating constipation. The preparation method for the pills comprises the following steps: (1) taking fructus cannabis, Chinese dwarf cherry seed, astragalus mongholicus, largehead atractylodes rhizome, dried radix rehmanniae and radix scrophulariae, crushing by a material string method and screening by a 100-mesh screen for later use; crushing cistanche and codonopsis pilosula to fine powder and screening the 100-mesh screen for later use; crushing rhubarb to fine powder and screening by the 100-mesh screen for later use; soaking costustoot for 1 hour with proper amount of water, extracting volatile oil by a volatile oil extractor and preparing volatile oil beta- cyclodextrin inclusion compound for later use by using a saturated solution; decocting rhizoma cyperi, semen cassiae, stir-fried radish seed, radix ophiopogonis and costustoot dreg twice with water and concentrating into a mixture with the ratio of decoction and raw medicine material being 1 to 1 for later use; (2) taking rhubarb powder in step (1) and a part of water decoction for stripping and pilling the inner layers; drying the inner layers at temperature of below 40 DEG C; pilling the middle layer by using cistanche, codonopsis pilosula, beta-cyclodextrin inclusion compound of costus root essential oils, and part of decoction, and drying at the temperature of below 40DEG C; and pilling the outer layers by using fructus cannabis, Chinese dwarf cherry seed, astragalus mongholicus, largehead atractylodes rhizome, dried radix rehmanniae, radix scrophulariae and the rest of water decoction, and drying the obtained product at 50 DEG C to obtain the Chinese herbal medicine pills.

Description

A kind of Chinese herbal medicine pill for the treatment of constipation

Technical field:

The invention belongs to technical field of Chinese medicines, particularly a kind of Chinese herbal medicine pill for the treatment of constipation

Background technology:

Feces was detained of a specified duration at enteric cavity, surpass 48 hours, and large quantity of moisture is absorbed by intestinal wall, and dry, hard, the difficult discharge of lethal feces named constipation.The reason of the generation of constipation is many-sided, functional constipation, organic constipation are arranged, with improper dietary habit and life style, psychentonia, spleen and stomach function degeneration, functional activities of the body fluid virtual loss, birth defect, inflammatory stimulus, abuse cathartic and suppress consciously for a long time defecation, also have many medicines may cause or increase the weight of constipation.These common medicines comprise containing the antacid of aluminum or calcium, antihistaminic, anti-Parkinson medicine, calcareous complementary goods, diuretic, anesthetis, phenothiazine, tranquillizer, three ring analeptic etc.In general, the short-term constipation is little on the impact of human body, but constipation can not get correction for a long time, and intrarectal harmful substance can not be got rid of in time, can produce harmful effect to human body, as recial disease hemorrhoid complicated by anal fistula, anal fissure, rectal cancer, even brings out sudden death.

Summary of the invention:

The invention provides a kind of Chinese herbal medicine pill for the treatment of constipation, the present invention is achieved in that pharmaceutical formulation of the present invention is: the Rhizoma Atractylodis Macrocephalae 30 grams, Semen Cassiae 20 grams, the Radix Astragali 20 grams, Herba Cistanches 20 grams, Radix Codonopsis 15 grams, Semen Raphani (parched) 15 grams, Rhizoma Cyperi 15 grams, Fructus Cannabis 15 grams, the Radix Aucklandiae 10 grams, Radix Et Rhizoma Rhei 10 grams, Semen Pruni 12 grams, the Radix Rehmanniae 12 grams, Radix Ophiopogonis 9 gram and Radix Scrophulariae 9 grams.

Its method for making is: Fructus Cannabis, Semen Pruni, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae and the Radix Scrophulariae that get in said medicine (1) are pulverized with " flushing method ", cross 100 mesh sieves standby; Herba Cistanches, Radix Codonopsis powder are broken into fine powder, cross 100 mesh sieves standby; Radix Et Rhizoma Rhei powder is broken into fine powder, crosses 100 mesh sieves standby; The Radix Aucklandiae adds the appropriate immersion of water 1 hour, with volatile oil extractor, extracts volatile oil, adopts saturated solution to prepare volatile oil beta cyclodextrin inclusion complex, standby; Rhizoma Cyperi, Semen Cassiae, Semen Raphani (parched), Radix Ophiopogonis and Radix Aucklandiae medicinal residues decoct with water 2 times, merge fried liquid 2 times, are concentrated into-decocting liquid: the mixture that crude drug is 1: 1, and standby; (2) get the Radix Et Rhizoma Rhei powder pulverized in (1) step and the molding of part decocting liquid, general ball internal layer, below 40 ℃, drying, use again Benexate Hydrochloride and the part decocting liquid flooding ball middle level of Herba Cistanches, Radix Codonopsis powder, volatile oil of Radix Aucklandiae, below 40 ℃, drying, use again Fructus Cannabis, Semen Pruni, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae, Radix Scrophulariae powder and residue decocting liquid flooding ball skin, be drying to obtain at 50 ℃.

Method for making explanation: Fructus Cannabis contains significant quantities of fat oil meal easy agglomerating, sticky screen cloth when broken, therefore the Fructus Cannabis of getting fire, the Radix Astragali and the Rhizoma Atractylodis Macrocephalae are pulverized with " flushing method "; The Radix Aucklandiae contains volatile oil, with volatile oil extractor, extracts, and volatile oil is volatile and meet light, thermally labile, but is beneficial to preservation, steady quality after beta-cyclodextrin inclusion compound.

Dosage form design is 3 layers of minutes molten concentrated pills: outer first molten, work hard clear and rich, and increase liquid and sail a boat; Middle level is continued molten, air making-up and spleen enlivening, and ascending the clear and descending the turbid, promote gastrointestinal peristalsis, molten after 3 layers, under rush down at logical mansion, by dirty toxin expelling.

Instructions of taking: 5 o'clock every afternoons are (medicine) being taken before meal 10～20 balls before the meal, and warm water is sent down, through about 15 hours, to morning next day, can soft stool of unimpeded discharge be good.Also to coordinate in addition regular medicine taking, the custom of defecation, polydipsia boiled water, polyphagia vegetable on time.

Side separates: insufficiency of the spleen, gastrointestinal peristalsis is unable, Rhizoma Atractylodis Macrocephalae sweetness and bitterness and temperature, large tonifying the spleen and stomach, sweet can the spleen invigorating invigorating the spleen and replenishing QI, bitter can be except damp and hot in stomach, taste are good for and are consolidated, therefore be monarch; The mansion that spleen is vigour, Radix Astragali tonifying Qi and lifting yang, hemopoietic, hidroschesis Gu Wei, gastrointestinal promotes strong; The Radix Codonopsis strongly invigorating primordial QI, principal drug assistance air making-up and spleen enlivening power times, therefore be minister; Rhizoma Atractylodis Macrocephalae resolving and invigoration therapies being applied simultaneously; Semen Raphani (parched) sending down the abnormal ascending QI de-swelling; The Radix Aucklandiae, Rhizoma Cyperi regulating the flow of QI to alleviate depression are capable stagnant; Semen Cassiae enrich blood tonifying YIN, heat clearing away softening the hard mass; Fructus Cannabis YIN nourishing tonify deficiency loosening bowel to relieve constipation, invigorate blood circulation in the logical mansion of Radix Et Rhizoma Rhei, and Semen Pruni is moisturized, laxation; The Radix Rehmanniae, Radix Ophiopogonis and Radix Scrophulariae heat clearing away YIN nourishing, change intestinal because of the dry symptom of heat; Full side plays that spleen invigorating is actuated altogether, the merit of loosening bowel to relieve constipation, dissolving blood stasis and detoxication.

Modern pharmacology shows: Herba Cistanches can strengthen enterokinesia, and the effect that promotes defecation is arranged; Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae have the effect of excited gastrointestinal motility, and Fructus Cannabis increases the liquid institute's fatty acids of sailing a boat can stimulate juice to increase, and reduces moisture absorption, increases osmotic pressure in enteric cavity, promotes enterokinesia.Radix Et Rhizoma Rhei has the stimulation intestinal wall, improves intestinal and shrinks, and the intestinal secretion thing is increased, and causes intestinal contents and is easy to the effect of discharging, and is applicable to various constipation.

The specific embodiment:

A kind of Chinese herbal medicine pill for the treatment of constipation, pharmaceutical formulation of the present invention is: the Rhizoma Atractylodis Macrocephalae 30 grams, Semen Cassiae 20 grams, the Radix Astragali 20 grams, Herba Cistanches 20 grams, Radix Codonopsis 15 grams, Semen Raphani (parched) 15 grams, Rhizoma Cyperi 15 grams, Fructus Cannabis 15 grams, the Radix Aucklandiae 10 grams, Radix Et Rhizoma Rhei 10 grams, Semen Pruni 12 grams, the Radix Rehmanniae 12 grams, Radix Ophiopogonis 9 gram and Radix Scrophulariae 9 grams.Its method for making is: Fructus Cannabis, Semen Pruni, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae and the Radix Scrophulariae that get in said medicine (1) are pulverized with " flushing method ", cross 100 mesh sieves standby; Herba Cistanches, Radix Codonopsis powder are broken into fine powder, cross 100 mesh sieves standby; Radix Et Rhizoma Rhei powder is broken into fine powder, crosses 100 mesh sieves standby; The Radix Aucklandiae adds the appropriate immersion of water 1 hour, with volatile oil extractor, extracts volatile oil, adopts saturated solution to prepare volatile oil beta cyclodextrin inclusion complex, standby; Rhizoma Cyperi, Semen Cassiae, Semen Raphani (parched), Radix Ophiopogonis and Radix Aucklandiae medicinal residues decoct with water 2 times, merge fried liquid 2 times, are concentrated into-decocting liquid: the mixture that crude drug is 1: 1, and standby; (2) get the Radix Et Rhizoma Rhei powder pulverized in (1) step and the molding of part decocting liquid, general ball internal layer, below 40 ℃, drying, use again Benexate Hydrochloride and the part decocting liquid flooding ball middle level of Herba Cistanches, Radix Codonopsis powder, volatile oil of Radix Aucklandiae, below 40 ℃, drying, use again Fructus Cannabis, Semen Pruni, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae, Radix Scrophulariae powder and residue decocting liquid flooding ball skin, be drying to obtain at 50 ℃.

The case checking:

By these side's treatment constipation 78 examples, medication 5th is a course for the treatment of, produce effects 3 examples.Medication cured person 70 examples on the 5th～15.Wherein, 1 the course for the treatment of healing person's 49 examples; 2 the course for the treatment of healing person's 28 examples; 3 the course for the treatment of healing person's 1 example, total effective rate 100%, follow up a case by regular visits to and have no recurrence pre-later six months.

Model case is introduced:

1, certain man, 56 years old, because of the cerebral infarction hospitalization, difficult defecation, appearred in clinotherapy all day, 3～5 without awareness of defecation, for a long time difficult defecation.Give each 20 balls of constipation ball therewith, every day 2 times, second day awareness of defecation occurs morning, adheres to once a day later, and each 20 balls, defecate 2 days 1 time, and very rule, follow up a case by regular visits to after 3 months without recurrence.

2, Wang, the female, 42 years old, suspicious, vexed because of sensitivity, worry too much, insomnia, outpatient service is taken in institute with schizophrenia, gives and risperidone treatment, occurs that stool is more dry, difficult defecation, the every day 1 time of taking this medicine, each 20 balls, rear stool is once a day.

3, Deng, the man, 68 years old, suffer from habitual constipation 6 years, the informal dress phenolphthalein tablet, poor effect, changed the glycerin external afterwards, rear useful pill, free movement of the bowels, rule, blood pressure stabilization.Follow up a case by regular visits to 1 year without recurrence.

4, Lee, 67 years old, because of slow in action after hypertension, cerebral infarction, insomnia, fidgety being admitted to hospital, constipation was serious, about 3～5 days stool once, very stiff, there is no positive effect by polyphagia vegetable, fruit, 3 yet not effects of oral phenolphthalein tablets, often use glycerin, use this Chinese medicine pill instead, the rule of defecating after 3 days, 1～3 day is once.

5, Jin, the man, 28 years old, because heavy drinking repeatedly causes bifilar head necrosis, give and hip replacement, postoperative constipation appears, to give orally with this Chinese herbal medicine pill, stool once a day, is consolidated after 10 days after drug withdrawal without repeatedly.

Claims

1. a Chinese herbal medicine pill for the treatment of constipation, pharmaceutical formulation is, the Rhizoma Atractylodis Macrocephalae 30 grams, Semen Cassiae 20 grams, the Radix Astragali 20 grams, Herba Cistanches 20 grams, Radix Codonopsis 15 grams, Semen Raphani (parched) 15 grams, Rhizoma Cyperi 15 grams, Fructus Cannabis 15 grams, the Radix Aucklandiae 10 grams, Radix Et Rhizoma Rhei 10 grams, Semen Pruni 12 grams, the Radix Rehmanniae 12 grams, Radix Ophiopogonis 9 gram and Radix Scrophulariae 9 grams; It is characterized in that:

(1) Fructus Cannabis, Semen Pruni, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae and the Radix Scrophulariae got in said medicine are pulverized with " flushing method ", cross 100 mesh sieves standby; Herba Cistanches, Radix Codonopsis powder are broken into fine powder, cross 100 mesh sieves standby; Radix Et Rhizoma Rhei powder is broken into fine powder, crosses 100 mesh sieves standby; The Radix Aucklandiae adds the appropriate immersion of water 1 hour, with volatile oil extractor, extracts volatile oil, adopts saturated solution to prepare volatile oil beta cyclodextrin inclusion complex, standby; Rhizoma Cyperi, Semen Cassiae, Semen Raphani (parched), Radix Ophiopogonis and Radix Aucklandiae medicinal residues decoct with water 2 times, merge fried liquid 2 times, are concentrated into-decocting liquid: the mixture that crude drug is 1: 1, and standby;

(2) get the Radix Et Rhizoma Rhei powder pulverized in (1) step and the molding of part decocting liquid, general ball internal layer, below 40 ℃, drying, use again Benexate Hydrochloride and the part decocting liquid flooding ball middle level of Herba Cistanches, Radix Codonopsis powder, volatile oil of Radix Aucklandiae, below 40 ℃, drying, use again Fructus Cannabis, Semen Pruni, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae, Radix Scrophulariae powder and residue decocting liquid flooding ball skin, be drying to obtain at 50 ℃.