CN104984309A - Traditional Chinese medicine composition for treating cholecystitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating cholecystitis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating cholecystitis. The traditional Chinese medicine composition comprises radix bupleuri, scutellaria baicalensis, dried ginger, fructus aurantii, pseudo-ginseng, safflower carthamus, rhizoma sparganii, oriental wormwood, radix gentianae, carcuma longa, fingered citron, fructus aurantii immaturus, cassia twigs, jasmine and rhizoma corydalis. Compared with simple western medicine treatment, cholecystitis can be better relieved, clinic symptoms of patients are improved, cholecystitis is prevented from being further worsened, toxic and side effects are not generated, and high safety and comfort are achieved.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of Chinese medicine composition being used for the treatment of cholecystitis and preparation method thereof.
Background technology
Cholecystitis is modal one in gallbladder disease, clinical common are acute and chronic point, and most merging pancreatitis, women's sickness rate is higher, age of onset is most between 20 ~ 50 years old, acute cholecystitis may be first time outbreak, also may show effect time and again on chronic cholecystitis basis, and during outbreak, patient is often in face of acute ill.Its main clinical manifestation is: stomachache, often betides the evening after heavy meal, generally all very violent, and in persistence, the aggravation in paroxysmal sometimes, mainly in epigastrium during beginning, be transferred to upper right abdomen gradually, some cases pain can be radiated to right shoulder back.Heating, body temperature is everlasting between 38 ~ 39 DEG C.Doublely can see the gastrointestinal symptoms such as inappetence, Nausea and vomiting, abdominal distention and a large amount of belch simultaneously.Chronic cholecystitis often lacks classical symptom, also can be asymptomatic, if without acute attack history, often not easily make a definite diagnosis, symptom often shows as the abdominal distention that weight differs, epigastrium or right upper quadrant of the abdomen discomfort, continue dull pain or right omoplate district pain, the indigestion symptoms such as scorching hot, belch, pantothenic acid, on the feed after oils food, symptom can increase the weight of.Motherland's medical science think primary disease be due to eating and drinking without temperance, greasy food of taking food, cold temperature is uncomfortable, feelings will is smooth and the fierce element such as malnutrition due to parasitic infestation, cause QI stagnation of the liver and galibladder, damp and hot heap soil or fertilizer over and around the roots resistance, logically fall not normal forming, treatment should with depressed liver-energy dispersing and function of gallbladder promoting, and dehumidifying of regulating the flow of vital energy is main; Acute pancreatitis is abdominal surgery commonly encountered diseases, and Severe Pancreatitis sickness rate increases gradually in recent years.Because it upsets large to physiology, and to each important organ infringement obviously, therefore mortality rate is very high.
Use antibiotic more to the Drug therapy of acute and chronic cholecystitis, acute and chronic pancreatitis at present, but because of the problem such as drug resistance and toxic and side effects, be difficult to treatment, above-mentioned disease there is no desirable treatment medicine at present, especially to the suppression of the bacteriological infection of gallbladder, promote the secretion of bile, improve immunity of organisms, reduce the desirable medicine of recurrence, still have to be developed.Need curative effect rapid, effect is certain, has no side effect for this reason, can prevent recurrence, and can limit the medicine taken by longer-term.
Object of the present invention overcomes the deficiencies such as large, the existing Chinese Herbs of Western medicine side effect is not remarkable exactly, according to traditional Chinese medical science prescription and preparation principle, Chinese medicine composition is developed meticulously, the advantages such as one is pointed by force, good effect, the cycle is short, price is low, have no side effect are provided, patient can be made again to take like a shot, the Chinese medicine composition of cholecystitis can be treated preferably.Each component collaborative onset mutually in side, and medicine is prepared simple, rapid-action, short treating period, is had good therapeutical effect to cholecystitis.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition being used for the treatment of cholecystitis, and its more simple western medicine better can reduce the index of cholecystitis, improves the clinical sign of patient, prevents cholecystitis from worsening further.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition being used for the treatment of cholecystitis, its raw material components comprises Radix Bupleuri, Radix Scutellariae, Rhizoma Zingiberis, Fructus Aurantii, Radix Notoginseng, Flos Carthami, Rhizoma Sparganii, Herba Artemisiae Scopariae, Radix Gentianae, Rhizoma Curcumae Longae, Fructus Citri Sarcodactylis, Fructus Aurantii Immaturus, Ramulus Cinnamomi, Fructus Gardeniae and Rhizoma Corydalis.
Wherein, in described Chinese medicine composition, the weight portion of each raw material components is respectively Radix Bupleuri 8-12 weight portion, Radix Scutellariae 6-10 weight portion, Rhizoma Zingiberis 4-10 weight portion, Fructus Aurantii 5-10 weight portion, Radix Notoginseng 4-9 weight portion, Flos Carthami 8-16 weight portion, Rhizoma Sparganii 8-17 weight portion, Herba Artemisiae Scopariae 5-11 weight portion, Radix Gentianae 4-10 weight portion, Rhizoma Curcumae Longae 7-14 weight portion, Fructus Citri Sarcodactylis 10-18 weight portion, Fructus Aurantii Immaturus 8-12 weight portion, Ramulus Cinnamomi 12-18 weight portion, Fructus Gardeniae 5-10 weight portion, Rhizoma Corydalis 6-12 weight portion.
Preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively Radix Bupleuri 10-12 weight portion, Radix Scutellariae 8-10 weight portion, Rhizoma Zingiberis 7-10 weight portion, Fructus Aurantii 8-10 weight portion, Radix Notoginseng 7-9 weight portion, Flos Carthami 11-16 weight portion, Rhizoma Sparganii 14-17 weight portion, Herba Artemisiae Scopariae 8-11 weight portion, Radix Gentianae 7-10 weight portion, Rhizoma Curcumae Longae 11-14 weight portion, Fructus Citri Sarcodactylis 14-18 weight portion, Fructus Aurantii Immaturus 10-12 weight portion, Ramulus Cinnamomi 15-18 weight portion, Fructus Gardeniae 7-10 weight portion, Rhizoma Corydalis 9-12 weight portion.
Further preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively Radix Bupleuri 10 weight portion, Radix Scutellariae 8 weight portion, Rhizoma Zingiberis 7 weight portion, Fructus Aurantii 8 weight portion, Radix Notoginseng 7 weight portion, Flos Carthami 11 weight portion, Rhizoma Sparganii 14 weight portion, Herba Artemisiae Scopariae 8 weight portion, Radix Gentianae 7 weight portion, Rhizoma Curcumae Longae 11 weight portion, Fructus Citri Sarcodactylis 14 weight portion, Fructus Aurantii Immaturus 10 weight portion, Ramulus Cinnamomi 15 weight portion, Fructus Gardeniae 7 weight portion, Rhizoma Corydalis 9 weight portion.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, its preparation process is:
(1) each component in described raw material components is mixed in proportion, cleans roguing, dry, pulverize;
(2) add water and cover powder 2cm, soak 1h, pull medical material out, decoct with water secondary, the water of first time totalling medical material 10-12 times amount, decocts 2h, gets decocting liquid, filter, second time adds up the water of medical material 8-10 times amount, decocts 1h, gets twice decocting liquid and merges, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.13-1.21g/mL;
(3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 2.7-3.3g crude drug amount, sets to 0-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, obtains medicinal liquid.
The present invention also provides the application of above-mentioned raw materials component in the Chinese medicine composition for the preparation for the treatment of cholecystitis.
Beneficial effect of the present invention:
The invention provides a kind of Chinese medicine composition being used for the treatment of cholecystitis, its more simple Western medicine and existing treatment by Chinese herbs better can alleviate cholecystitis, improve the clinical sign of patient, prevent cholecystitis from worsening further, have no side effect simultaneously, have safety and the comfort of height.
Detailed description of the invention
The weight portion that the present invention mentions is a proportionate relationship between each component.
The invention provides a kind of Chinese medicine composition being used for the treatment of cholecystitis, its raw material components comprises Radix Bupleuri, Radix Scutellariae, Rhizoma Zingiberis, Fructus Aurantii, Radix Notoginseng, Flos Carthami, Rhizoma Sparganii, Herba Artemisiae Scopariae, Radix Gentianae, Rhizoma Curcumae Longae, Fructus Citri Sarcodactylis, Fructus Aurantii Immaturus, Ramulus Cinnamomi, Fructus Gardeniae and Rhizoma Corydalis.
Further preferably, described Chinese medicine composition is only made up of above-mentioned raw materials component.
Chinese medicine composition compatibility of the present invention is reasonable, and action effect is remarkable, wherein:
Radix Bupleuri: pungent, bitter, is slightly cold; Evacuation is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy; For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
Radix Scutellariae: bitter, cold; Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive; For hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Rhizoma Zingiberis: pungent, heat; Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, warming the lung to resolve fluid-retention; For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, cold fluid-retention is breathed with cough.
Fructus Aurantii: bitter, pungent, sour, is slightly cold; Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row; For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention, visceroptosis.
Radix Notoginseng: sweet, micro-hardship, temperature; Dissipating blood stasis stops blooding, subduing swelling and relieving pain; For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.
Flos Carthami: pungent, temperature; Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain; For amenorrhea, dysmenorrhea, lochia ， mass in the abdomen mass in the abdomen, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, injury from falling down, skin infection swells and ache.
Rhizoma Sparganii: pungent, bitter is flat; Removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving; Yong Yu mass in the abdomen mass in the abdomen, dysmenorrhea, blood stasis amenorrhea, obstruction of qi in the chest and cardialgia, food stagnation distending pain.
Herba Artemisiae Scopariae: bitter, pungent, is slightly cold; Eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice; For jaundice oliguria, hygropyrexia heat-damp in summer, eczema pruritus.
Radix Gentianae: bitter, cold; Heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire; For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, eczema scabies ancient term for country school, liver-fire conjunctival congestion, Hiccough and deaf, hypochondriac pain bitter taste, persistent erection of the penis, convulsion with spasms.
Rhizoma Curcumae Longae: pungent, bitter, temperature; Removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia; For the twinge of the breast side of body, obstruction of qi in the chest and cardialgia, dysmenorrhea amenorrhea, tumor abdominal mass, rheumatism shoulder arm pain, tumbling and swelling.
Fructus Citri Sarcodactylis: pungent, bitter, sour, temperature; Depressed liver-energy dispersing and QI regulating, and stomach and alleviating pain, drying dampness to eliminate phlegm; For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted, cough with copious phlegm.
Fructus Aurantii Immaturus: bitter, pungent, sour, is slightly cold; Dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm; Stop in stagnant, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock of expectorant, the thoracic obstruction, blocked-up chest, visceroptosis.
Ramulus Cinnamomi: acrid, sweet, warm; Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins; For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Fructus Gardeniae: bitter, cold; Pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; Externally used detumescence pain relieving; Vexed for calentura, jaundice due to damp-heat, the puckery pain of stranguria, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.
Rhizoma Corydalis: pungent, bitter, temperature; Invigorate blood circulation, circulation of qi promoting, pain relieving; For the breast side of body, epigastric pain, obstruction of qi in the chest and cardialgia, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
In described Chinese medicine composition, the weight portion of each raw material components is respectively Radix Bupleuri 8-12 weight portion, Radix Scutellariae 6-10 weight portion, Rhizoma Zingiberis 4-10 weight portion, Fructus Aurantii 5-10 weight portion, Radix Notoginseng 4-9 weight portion, Flos Carthami 8-16 weight portion, Rhizoma Sparganii 8-17 weight portion, Herba Artemisiae Scopariae 5-11 weight portion, Radix Gentianae 4-10 weight portion, Rhizoma Curcumae Longae 7-14 weight portion, Fructus Citri Sarcodactylis 10-18 weight portion, Fructus Aurantii Immaturus 8-12 weight portion, Ramulus Cinnamomi 12-18 weight portion, Fructus Gardeniae 5-10 weight portion, Rhizoma Corydalis 6-12 weight portion.
Preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively Radix Bupleuri 10-12 weight portion, Radix Scutellariae 8-10 weight portion, Rhizoma Zingiberis 7-10 weight portion, Fructus Aurantii 8-10 weight portion, Radix Notoginseng 7-9 weight portion, Flos Carthami 11-16 weight portion, Rhizoma Sparganii 14-17 weight portion, Herba Artemisiae Scopariae 8-11 weight portion, Radix Gentianae 7-10 weight portion, Rhizoma Curcumae Longae 11-14 weight portion, Fructus Citri Sarcodactylis 14-18 weight portion, Fructus Aurantii Immaturus 10-12 weight portion, Ramulus Cinnamomi 15-18 weight portion, Fructus Gardeniae 7-10 weight portion, Rhizoma Corydalis 9-12 weight portion.
Further preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively Radix Bupleuri 10 weight portion, Radix Scutellariae 8 weight portion, Rhizoma Zingiberis 7 weight portion, Fructus Aurantii 8 weight portion, Radix Notoginseng 7 weight portion, Flos Carthami 11 weight portion, Rhizoma Sparganii 14 weight portion, Herba Artemisiae Scopariae 8 weight portion, Radix Gentianae 7 weight portion, Rhizoma Curcumae Longae 11 weight portion, Fructus Citri Sarcodactylis 14 weight portion, Fructus Aurantii Immaturus 10 weight portion, Ramulus Cinnamomi 15 weight portion, Fructus Gardeniae 7 weight portion, Rhizoma Corydalis 9 weight portion.
The Chinese medicine composition for the treatment of cholecystitis provided by the invention can be prepared into various peroral dosage form according to regular dosage form preparation method.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, comprising:
(1) each component in described raw material components is mixed in proportion, cleans roguing, dry, pulverize;
(2) add water and cover powder 2cm, soak 1h, pull medical material out, decoct with water secondary, the water of first time totalling medical material 10-12 times amount, decocts 2h, gets decocting liquid, filter, second time adds up the water of medical material 8-10 times amount, decocts 1h, gets twice decocting liquid and merges, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.13-1.21g/mL;
(3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 2.7-3.3g crude drug amount, sets to 0-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, obtains medicinal liquid.
The present invention also provides the application of above-mentioned raw materials component in the Chinese medicine composition for the preparation for the treatment of cholecystitis.
Embodiment
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1
Get Radix Bupleuri 8 weight portion, Radix Scutellariae 6 weight portion, Rhizoma Zingiberis 4 weight portion, Fructus Aurantii 5 weight portion, Radix Notoginseng 4 weight portion, Flos Carthami 8 weight portion, Rhizoma Sparganii 8 weight portion, Herba Artemisiae Scopariae 5 weight portion, Radix Gentianae 4 weight portion, Rhizoma Curcumae Longae 7 weight portion, Fructus Citri Sarcodactylis 10 weight portion, Fructus Aurantii Immaturus 8 weight portion, Ramulus Cinnamomi 12 weight portion, Fructus Gardeniae 5 weight portion, Rhizoma Corydalis 6 weight portion, is mixed in proportion, clean roguing, dry, pulverize; Add water and cover powder 2cm, soak 1h, pull medical material out, decoct with water secondary, add up the water of medical material 10 times amount for the first time, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decocts 1h, gets twice decocting liquid and merges, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.13g/mL; Concentrated solution is put 4 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 2.7g crude drug amount, puts 4 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, obtains medicinal liquid.
Usage and consumption: every day one after each meal three times.
Taboo: (1) avoids eating anything raw or cold food; (2) diet raw meat thing; (3) internal and external haemorrhage disease, ulcerate disease tool avoid clothes first; (4) female menstrual period, the pregnancy period is not used.
Embodiment 2
Get Radix Bupleuri 12 weight portion, Radix Scutellariae 10 weight portion, Rhizoma Zingiberis 10 weight portion, Fructus Aurantii 10 weight portion, Radix Notoginseng 9 weight portion, Flos Carthami 16 weight portion, Rhizoma Sparganii 17 weight portion, Herba Artemisiae Scopariae 11 weight portion, Radix Gentianae 10 weight portion, Rhizoma Curcumae Longae 14 weight portion, Fructus Citri Sarcodactylis 18 weight portion, Fructus Aurantii Immaturus 12 weight portion, Ramulus Cinnamomi 18 weight portion, Fructus Gardeniae 10 weight portion, Rhizoma Corydalis 12 weight portion, is mixed in proportion, clean roguing, dry, pulverize; Add water and cover powder 2cm, soak 1h, pull medical material out, decoct with water secondary, add up the water of medical material 12 times amount for the first time, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 10 times amount, decocts 1h, gets twice decocting liquid and merges, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.21g/mL; Concentrated solution is put 4 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 3.3g crude drug amount, puts 4 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, obtains medicinal liquid.
Usage and consumption, avoid same embodiment 1.
Embodiment 3
Get Radix Bupleuri 10 weight portion, Radix Scutellariae 8 weight portion, Rhizoma Zingiberis 7 weight portion, Fructus Aurantii 8 weight portion, Radix Notoginseng 7 weight portion, Flos Carthami 11 weight portion, Rhizoma Sparganii 14 weight portion, Herba Artemisiae Scopariae 8 weight portion, Radix Gentianae 7 weight portion, Rhizoma Curcumae Longae 11 weight portion, Fructus Citri Sarcodactylis 14 weight portion, Fructus Aurantii Immaturus 10 weight portion, Ramulus Cinnamomi 15 weight portion, Fructus Gardeniae 7 weight portion, Rhizoma Corydalis 9 weight portion, is mixed in proportion, clean roguing, dry, pulverize; Add water and cover powder 2cm, soak 1h, pull medical material out, decoct with water secondary, add up the water of medical material 11 times amount for the first time, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 9 times amount, decocts 1h, gets twice decocting liquid and merges, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.18g/mL; Concentrated solution is put 4 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 3.0g crude drug amount, puts 4 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, obtains medicinal liquid.
Usage and consumption, avoid same embodiment 1.
Embodiment 4 toxicity is verified
Below test, without special instruction, all use the Chinese medicine composition that the embodiment of the present invention 3 is obtained.
1, acute toxicity test: mouse stomach gives Chinese medicine composition 121.47g/kg of the present invention, Continuous Observation 14 days, all survive, and growth promoter is good.Mice is 121.47g/kg to Chinese medicine composition maximum dosage-feeding of the present invention.
2, long term toxicity test: to continuous 6 weeks of SD rat respectively gavage give 58.5g/kg, 29.4g/kg, the Chinese medicine composition of the present invention of 14.1g/kg tri-dosage, laboratory animal terminates and convalescent period in administration, and hematological indices, blood parameters and matched group ratio are all without significant difference (p > 0.05).System becomes celestial and histopathologic examination has no drug-induced abnormal change and retardance toxic reaction.
Embodiment 5 zoopery
1. on the impact of rat function of gallbladder promoting and bile component
Result shows, Chinese medicine composition of the present invention has good choleretic effect, and shows obvious dose-effect relationship.Bile studied display cholesterol level reduces (P < 0.01), can reduce content of bilirubin (P < 0.01), increase Bile acid (P < 0.01).Show that Chinese medicine composition of the present invention improves function for having with lipid metabolism and digestive function related component in bile.
2, anti-inflammation effect
(1) impact of mice caused by dimethylbenzene xylene ear swelling: the swelling of Chinese medicine composition of the present invention is starkly lower than danshitong capsules matched group (P < 0.01).Illustrate that Chinese medicine composition of the present invention can obviously resist mice caused by dimethylbenzene xylene ear swelling.
(2) on Carrageenan causes the impact of rat paw edema: show that Chinese medicine composition on Carrageenan of the present invention causes the also better antagonism of tool of rat acute inflammation.
3, analgesic effect
(1) inhibitory action of Dichlorodiphenyl Acetate induced pain: show that Chinese medicine composition Dichlorodiphenyl Acetate induced pain of the present invention has inhibitory action.
(2) to the effect of thermostimulation induced pain: Chinese medicine composition of the present invention upon administration 0.5h can significantly improve the threshold of pain, and 5h (P < 0.01, P < 0.01) is maintained until.3.5g/kg group upon administration 5h also illustrates certain effect.As can be seen here, Chinese medicine composition of the present invention has analgesic activity to thermostimulation.
4, refrigeration function
Select healthy qualified rabbit.Positive control drug is aspirin (0.2g/kg), different time points body temperature raises average and shows, Chinese medicine composition of the present invention is starkly lower than aspirin group (P < 0.01), illustrates that Chinese medicine composition of the present invention has certain antipyretic response.
5, antibacterial and bactericidal action
Extracorporeal bacteria inhibitor test is with two times of dilution methods that successively decrease, and test result is that Chinese medicine composition of the present invention all has the antibacterial effect with sterilizing in various degree to 10 kinds of antibacterials.Wherein to staphylococcus aureus, staphylococcus epidermidis, streptococcus pneumoniae, beta hemolytic streptococcus, there is more antibacterial and bactericidal action; Escherichia coli, bacteroides fragilis, sramana's typhoid fever bacterium, bacillus pyocyaneus tool are better acted on; Though there is certain effect to pneumobacillus, enterococcus, act on weak compared with the former.
Embodiment 6 clinical experiment
1, case selection
Through hospital diagnosis, 200 examples are in hospital and out-patient is diagnosed as acute and chronic cholecystitis respectively.
2, group technology
200 routine patients are divided into treatment group and matched group at random.Treatment group 100 example, male 58 example, women 42 example.Age 25-55 year, average 42.6 years old.Matched group 100 example, male 53 example, women 47 example.Age 27-58 year, average 43.5 years old.
3, Therapeutic Method
Treatment group: oral Chinese medicine composition of the present invention, a 8ml, 3 times on the one.
Matched group: oral " pancreas DANSHU granule " (production of Tian Tai Pharmaceutical limited company of Jilin Province), a 10g, 2-3 time on the one.
The course for the treatment of: 14 days.
4, criterion of therapeutical effect
Checking gallbladder recovery situation etc. with symptom and sign situation, B ultrasonic is clinical appraisal index.
A. effective: symptom and sign disappears, B ultrasonic check shows that gallbladder recovers normal, without obvious pathological characters, and body weight or have increase.
B. effective: symptom and sign disappears substantially, B ultrasonic check shows that gallbladder pathological characters is improved, the non-complete stability person of the state of an illness.
C. invalid: symptom and sign have no improvement, B ultrasonic check shows that gallbladder has obvious pathological characters.
5, interpretation of result:
Experimental result is in table 1.Total effective rate=(effective number of cases+effectively number of cases)/total number of cases.
Table 1: the comparison of two groups of patient clinical curative effects after treatment
| Group | Total number of cases | Effective number of cases | Effective number of cases | Invalid number of cases | Total effective rate (%) |
| Treatment group | 100 | 79 | 19 | 2 | 98 |
| Matched group | 100 | 33 | 36 | 31 | 69 |
From upper table: treatment group 100 example, effective 79 examples, effective 19 examples, invalid 2 examples, total effective rate 98%.Matched group 100 example, effective 33 examples, effective 36 examples, invalid 31 examples, total effective rate 69%.Two groups are compared comparitive study difference between P < 0.01, two groups and have significance.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (6)
1. be used for the treatment of a Chinese medicine composition for cholecystitis, it is characterized in that: raw material components comprises Radix Bupleuri, Radix Scutellariae, Rhizoma Zingiberis, Fructus Aurantii, Radix Notoginseng, Flos Carthami, Rhizoma Sparganii, Herba Artemisiae Scopariae, Radix Gentianae, Rhizoma Curcumae Longae, Fructus Citri Sarcodactylis, Fructus Aurantii Immaturus, Ramulus Cinnamomi, Fructus Gardeniae and Rhizoma Corydalis.
2. Chinese medicine composition as claimed in claim 1, is characterized in that: the weight portion of each raw material components is respectively Radix Bupleuri 8-12 weight portion, Radix Scutellariae 6-10 weight portion, Rhizoma Zingiberis 4-10 weight portion, Fructus Aurantii 5-10 weight portion, Radix Notoginseng 4-9 weight portion, Flos Carthami 8-16 weight portion, Rhizoma Sparganii 8-17 weight portion, Herba Artemisiae Scopariae 5-11 weight portion, Radix Gentianae 4-10 weight portion, Rhizoma Curcumae Longae 7-14 weight portion, Fructus Citri Sarcodactylis 10-18 weight portion, Fructus Aurantii Immaturus 8-12 weight portion, Ramulus Cinnamomi 12-18 weight portion, Fructus Gardeniae 5-10 weight portion, Rhizoma Corydalis 6-12 weight portion.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that: the weight portion of each raw material components is respectively Radix Bupleuri 10-12 weight portion, Radix Scutellariae 8-10 weight portion, Rhizoma Zingiberis 7-10 weight portion, Fructus Aurantii 8-10 weight portion, Radix Notoginseng 7-9 weight portion, Flos Carthami 11-16 weight portion, Rhizoma Sparganii 14-17 weight portion, Herba Artemisiae Scopariae 8-11 weight portion, Radix Gentianae 7-10 weight portion, Rhizoma Curcumae Longae 11-14 weight portion, Fructus Citri Sarcodactylis 14-18 weight portion, Fructus Aurantii Immaturus 10-12 weight portion, Ramulus Cinnamomi 15-18 weight portion, Fructus Gardeniae 7-10 weight portion, Rhizoma Corydalis 9-12 weight portion.
4. the Chinese medicine composition as described in claims 1 to 3, is characterized in that: the weight portion that the weight portion of each raw material components is respectively each raw material components is respectively Radix Bupleuri 10 weight portion, Radix Scutellariae 8 weight portion, Rhizoma Zingiberis 7 weight portion, Fructus Aurantii 8 weight portion, Radix Notoginseng 7 weight portion, Flos Carthami 11 weight portion, Rhizoma Sparganii 14 weight portion, Herba Artemisiae Scopariae 8 weight portion, Radix Gentianae 7 weight portion, Rhizoma Curcumae Longae 11 weight portion, Fructus Citri Sarcodactylis 14 weight portion, Fructus Aurantii Immaturus 10 weight portion, Ramulus Cinnamomi 15 weight portion, Fructus Gardeniae 7 weight portion, Rhizoma Corydalis 9 weight portion.
5. the preparation method of Chinese medicine composition described in Claims 1-4, is characterized in that, preparation process is:
(1) each component in described raw material components is mixed in proportion, cleans roguing, dry, pulverize;
(2) add water and cover powder 2cm, soak 1h, pull medical material out, decoct with water secondary, the water of first time totalling medical material 10-12 times amount, decocts 2h, gets decocting liquid, filter, second time adds up the water of medical material 8-10 times amount, decocts 1h, gets twice decocting liquid and merges, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.13-1.21g/mL;
(3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 2.7-3.3g crude drug amount, sets to 0-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, obtains medicinal liquid.
6. the application of the raw material components any one of claim 1-4 in the Chinese medicine composition for the preparation for the treatment of cholecystitis.
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| CN101279083A (en) * | 2008-05-15 | 2008-10-08 | 包瑞 | Chinese medicine preparation for curing acute or chronic cholecystitis and method of preparing the same |
| CN103550698A (en) * | 2013-11-01 | 2014-02-05 | 陈小莉 | Traditional Chinese medicine composition for treating acute cholecystitis |
| CN104189163A (en) * | 2014-08-21 | 2014-12-10 | 李芝芳 | Traditional Chinese medicine formula for treating cholecystitis |
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| RU2098108C1 (en) * | 1995-12-26 | 1997-12-10 | Евгений Иванович Трифонов | Apitherapeutic agent |
| CN101279083A (en) * | 2008-05-15 | 2008-10-08 | 包瑞 | Chinese medicine preparation for curing acute or chronic cholecystitis and method of preparing the same |
| CN103550698A (en) * | 2013-11-01 | 2014-02-05 | 陈小莉 | Traditional Chinese medicine composition for treating acute cholecystitis |
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Application publication date: 20151021 |