CN102631449B - Chinese medicinal composition for treating acute pancreatitis - Google Patents
Chinese medicinal composition for treating acute pancreatitis Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating acute pancreatitis, and relates to the technical field of Chinese medicine. The Chinese medicinal composition is prepared from the following nine natural Chinese medicinal materials in parts by weight: 30 to 60 parts of radix scutellariae, 30 to 60 parts of dandelion, 30 to 50 parts of sargentg loryvine stem, 20 to 40 parts of immature bitter orange, 18 to 38 parts of radix bupleuri, 20 to 40 parts of saussurea costus, 18 to 48 parts of radish seed, 22 to 46 parts of rosewood heart wood and 22 to 46 parts of frankincense. Compared with the prior art, the Chinese medicinal composition has the advantages of simple preparation process, simple administration, fast effect after drug administration to a patient, short course of treatment and remarkable curative effect.
Description
Technical field
The present invention relates to the Chinese medicine technical field, be specifically related to a kind of pancreatitic Chinese medicine composition for the treatment of.
Background technology
Pancreatitis refers to that Different types of etiopathogenises causes pancreatin to be activated in pancreas, after cause pancreatic tissue generation edema, hyperemia, hemorrhage even downright bad inflammatory reaction.It can be divided into acute and chronic two kinds, and the acute necrotizing pancreatitis oncoming force is dangerous, and the case fatality rate height, can reach 30～60%, is the common emergency case serious symptom of Gastroenterology dept..
The acute pancreatitis etiology and pathogenesis: because direct stimulation, eating and drinking without temperance such as crapulence, gluttony, drink, surfeit is greasy etc., cold temperature is uncomfortable, factors such as malnutrition due to parasitic infestation, make human body dysfunction, the pancreas disorder causes QI depression of the liver and gallbladder, the damp and hot resistance in middle Jiao, the logical mistake department of falling of QI of the spleen and stomach, retention of damp-heat in the interior and falling ill.Symptom: stomachache takes place suddenly, and multidigit often be persistence severe pain in the epigastrium side of taking back slightly, can be radiated to back and left shoulder bitterly, often with nausea and vomiting, and symptoms such as heating, fear of cold, excessive thirst, hyperhidrosis.Sign: (1) abdominal part: tenderness, muscle tonus, rebound tenderness.(2) tongue fur pulse condition: red tongue, yellowish fur, wiry and frequent pulse.Check: (1) is through the cave palpation: there is pressure pain point at three to five cun places under the tsusanli acupoint, and the right side of being everlasting is found.(2) laboratory examination: leukocyte increases, and neutrophilic granulocyte increases unusually.Blood, urine pancreatic amylase increase.
Present Therapeutic Method mainly contains: 1. fasting; 2. gastrointestinal decompression: put nasogastric tube in case of necessity and continue to attract gastrointestinal decompression, be applicable to stomachache, abdominal distention, vomiting severe patient; 3. venous transfusion is actively supplied blood volume, keeps Water-Electrolyte and acid-base balance, notes keeping the heat energy supply; 4. pain relieving: the violent person that suffers from abdominal pain can give Pethidine; 5. antibiotic: because acute pancreatitis is to belong to the chemical inflammation, antibiotic is also inessential; Yet China's acute pancreatitis takes place normal relevant with biliary tract, so custom is used clinically; As doubting concurrent infection, then must use; 6. press down the acid treatment: clinical custom is used Hz receptor antagonist or proton pump inhibitor intravenously administrable, thinks and can suppress pancreatic secretion by gastric acid inhibitory, has the effect of prevention stress ulcer concurrently.
The document of Chinese traditional treatment at present mainly contains: Chinese patent application number is that 03111109.2 patent of invention discloses a kind of pancreatitic Chinese medicine for the treatment of, and treatment pancreatitis effect significantly can reach recovery from illness.This technical scheme is made up of nearly 40 flavor Chinese medicines such as Rhizoma Cyperi, Radix Curcumae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Radix Bupleuri, Fructus Aurantii Immaturus, rhizoma sparganic.
Chinese patent application number is that 200310105814.3 patent of invention discloses a kind of plain baicalin injection of compound rubarb for the treatment of acute pancreatitis and preparation method thereof, the related Chinese medicine of this injection is the compound compatibility of emodin and two kinds of monomer components of baicalin, and the injection of the compound compatibility of various various dose is arranged.This injection is used for treating acute pancreatitis and has significant curative effect, obviously is better than independent use.
Chinese patent application number is that 201110274877.6 patent of invention discloses a kind of Chinese herbal medicine for the treatment of acute pancreatitis, is made by the medicine of following weight proportion: Radix Bupleuri 25-35 part; The yellow 25-35 part of trifoliate orange; Radix Paeoniae Rubra 15-25 part; Rhizoma Cyperi 25-35 part; Rhizoma Chuanxiong 25-35 part; Radix Curcumae 25-35 part; Rhizoma Corydalis 25-35 part; Radix Salviae Miltiorrhizae 25-35 part; Herba Taraxaci 15-25 part; Herba Portulacae Grandiflorae 15-25 part; Mountain pupa common house centipede rattan 35-45 part; Rhizoma Coptidis 15-25 part; Lose the careless 15-25 part of slurry; Herba Bidentis Bipinnatae 25-35 part; Add 1600 parts in water, boiled after, slow fire infusion 20-30 minute is filtered down and is collected supernatant, high temperature sterilize namely behind the mix homogeneously of bottling.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of acute pancreatitis.
In order to realize purpose of the present invention, Chinese medicine composition of the present invention is made by the raw material of following weight portion: Radix Scutellariae 30-60 part, Herba Taraxaci 30-60 part, Caulis Sargentodoxae 30-50 part, Fructus Aurantii Immaturus 20-40 part, Radix Bupleuri 18-38 part, Saussurea lappa Clarke 20-40 part, Semen Raphani 18-48 part, Lignum Dalbergiae Odoriferae 22-46 part, Olibanum 22-46 part.
Preferably, Chinese medicine composition of the present invention is made by the raw material of following weight portion: 48 parts of Radix Scutellariaes, 48 parts of Herba Taraxacis, 36 parts of Caulis Sargentodoxaes, 36 parts of Fructus Aurantii Immaturuss, 24 parts of Radix Bupleuri, 24 parts of Saussurea lappa Clarke, 36 parts of Semen Raphanis, 24 parts of Lignum Dalbergiae Odoriferaes, 24 parts of Olibanums.
Pancreas belongs to spleen, with stomach phase the exterior and the interior, has Tianjin pipe to be communicated with gallbladder, intestinal.The traditional Chinese medical science is thought and caused pancreatitic main cause: eating cold and uncooked food excessively, greasy delicious food, pure wine savoury cause spleen injury; Or feelings will do not relax, stagnation of QI due to depression of the liver, and long-pending, the ascarid of gallbladder pancreatolith harasses, block Tianjin and manages in addition, causes liver and gall stasis, the perverse and unreasonable manner taste; Or because of pathogenic heat, pyretic toxicity, many evil invasion and attack such as damp and hot, part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels function disorder in causing finally causes pancreatitis.
Chinese medicine composition of the present invention is collaborative mutually, and the stasis of blood is dredged with fixed attention, and QI and blood is able to benefit and mends, to control adverse rising of stomach-QI, internal organs gas do not fall, depression of liver-QI and pathogenic heat go in, effects such as Sheng, qi depression to blood stasis are remarkable in the excess-heat.Chinese medicine composition of the present invention can be repaired spleen injury comprehensively, and function of spleen and stomach regulating recovers the taste normal function, finally reaches the effect of the logical pancreas of silt heat clearing away of dispelling.
Side of the present invention separates:
Radix Scutellariae: hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Join Radix Bupleuri, in the logical mileometer adjustment, treating SHAO YANG disease by mediation; Join Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, stomach function regulating helps digestion.
Herba Taraxaci: sweet, little hardship, cold.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Cure mainly upper respiratory tract infection, eye conjunctivitis, mumps, hyperglycemia, acute mastitis swells and ache, gastritis, dysentery, hepatitis, gallbladder is assisted inflammation, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis is controlled acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.
Caulis Sargentodoxae: hardship, flat.Go into stomach, large intestine channel.Heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral, the dissipating blood stasis that relieves internal heat, wind dispelling insecticide.Be used for abdominalgia with intestinal abscess, traumatic injury, dysmenorrhea, Fengshi Guanjie pain.Caulis Sargentodoxae is good at the heat-clearing and toxic substances removing eliminating stagnation, and for controlling the key medicine of acute appendicitis, normal and Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Herba Taraxaci or Flos Lonicerae, Fructus Forsythiae, Cortex Moutan, Semen Coicis are equal to usefulness; Control acute mastitis and swell and ache, can be equal to usefulness with Herba Taraxaci, Radix Trichosanthis, Bulbus Fritillariae Uninbracteatae, Flos Lonicerae, Fructus Forsythiae, Spica Prunellae.
Fructus Aurantii Immaturus: hardship; Hot; Cold.Return spleen; Stomach; Liver; Heart channel.Stop in stagnant; The feeling of fullness distending pain; Constipation; Heavy behind the dysentery; Blocked-up chest; Gastroptosis; Uterine prolapse; Proctoptosis.
Radix Bupleuri: hardship, be slightly cold, return Liver Channel, gallbladder meridian.Evacuation is brought down a fever, the yang invigorating soothing liver-QI.Cure mainly cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, the uterus comes off, menoxenia.
Saussurea lappa Clarke: hot, bitter, temperature.Promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach.Be used for chest and abdomen swelling and pain, the dysentery tenesmus is had loose bowels in vomiting.Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, liver, large intestine channel, the fragrance row looses, and can rise and can fall.
Semen Raphani: nature and flavor: property is flat, acrid in the mouth, sweet.Return lung, spleen, stomach warp.Help digestion except expanding lowering the adverse-rising QI to resolve phlegm.Breath with cough for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots.Go into spleen, stomach, lung meridian, can help digestion except expanding, effect is remarkable, and the title of " falling wall towards wall " is arranged.
Lignum Dalbergiae Odoriferae: suffering, temperature.Return liver, spleen channel.Promoting flow of QI and blood, pain relieving, hemostasis.Be used for epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, traumatic hemorrhage.
Olibanum: arduous, temperature.Go into the heart, liver, spleen channel.Regulating qi and activating blood, analgesic therapy chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Chinese medicine composition of the present invention can give the consumption of each 2-4g respectively according to the difference of conditions of patients, and every day 3 times, the morning, noon and afternoon, respectively once taking medicine before meal was used.3 days courses for the treatment of of pharmaceutical composition of the present invention, serve on the 1-2 course for the treatment of.
Preparation process of the present invention is simple, and directly being pulverized and mixed evenly routinely, the preparation process preparation gets final product.Preferably, preparation process is made clinical acceptable peroral dosage form routinely.
Described peroral dosage form is liquid oral dosage form or oral dosage form, is preferably oral dosage form, and described oral dosage form is tablet, granule, capsule, soft capsule, pill.
Aforementioned dosage form most preferably is capsule.
The preparation method of capsule of the present invention is as follows:
A, according to the present invention prescription, take by weighing the raw medicinal material Radix Scutellariae, Herba Taraxaci, Caulis Sargentodoxae, Fructus Aurantii Immaturus, Radix Bupleuri, Saussurea lappa Clarke, Semen Raphani, Lignum Dalbergiae Odoriferae, Olibanum of recipe quantity etc.; Clean, dry;
B, with above-mentioned pulverizing medicinal materials, cross 80 mesh sieves, behind ultraviolet-sterilization, insert capsule No. 0, namely.
The present invention also can water is fried takes in addition.
It is simple that the present invention prescription compared with prior art has a preparation process, and medication is simplified; Instant effect after patient takes medicine, short treating period, characteristics evident in efficacy.Can effectively treat pancreatitis with and the stomachache, the nausea and vomiting that cause, symptoms such as heating, fear of cold, excessive thirst, hyperhidrosis.Treated at present and cured example surplus the patients with acute pancreatitis 450, cure rate can reach more than 80%, and effective percentage can reach more than 98%.
Chinese medicine composition clinical therapeutic efficacy situation of the present invention:
1. physical data
The patient is the acute pancreatitis clinic case, totally 90 examples, and wherein male 60 examples account for 67%, and women 30 examples account for 33%.Be equally divided into two groups of each 45 examples, treatment group and matched group.Patient's cardinal symptom:
1). stomachache, unexpected onset, the degree weight differs, and can be dull pain, lancinating pain, drilling pain or angor, is persistence, and the paroxysmal aggravation can be arranged, and can not be that general gastrointestinal antispasmodic medicine is alleviated, and feed can aggravate.Painful area is many at middle upper abdomen, can be banded radiation to lower back, and getting the position of bending over to tuck can ease the pain.
2). feel sick, vomiting and abdominal distention, quite frequent sometimes, spue food and bile, vomiting back stomachache does not alleviate.
3). heating, most of patients have the above heating of moderate, continue 3～5 days.Persistent fever do not move back more than one week or raise day by day, leukocyte rising person should suspect that secondary infection is arranged, as pancreatic abscess or biliary tract infection etc.
4). hypotension or shock.Patient's dysphoria, palor, clammy etc.; The only a few shock is arranged.
5). the dehydration that water, electrolyte, acid-base balance and metabolism disorder have weight not wait more, hypokalemia, vomiting frequently can have metabolic alkalosis.Serious symptom person still has obvious dehydration and metabolic acidosis, hypocalcemia (＜2retool/L), part accompanies blood glucose to increase, and diabetic ketoacidosis or hyperosmolar coma can take place in idol.
2. Therapeutic Method:
The treatment group is got the embodiment of the invention 1 capsule, every day 3 times, the morning, noon and afternoon each once, half an hour after meal.3 days courses for the treatment of, serve on the 1-2 course for the treatment of.Matched group is given and pancreatitis conventional therapy medicine " pancreas soup " by above-mentioned method of administration.
3. observation of curative effect and evaluation criteria: observe patient's ordinary circumstance, abdominal symptoms and sign; 3rd, capable APACHE-II scoring in 6 days, and detect serum amylase, change of serum C RP, tumor necrosis factor (TNF-α), urine lactulose/mannitol ratio.
Clinical recovery: symptom, sign are alleviated in 3 days, disappear within 4-6 days, and blood, amylase in urine recover normal.
Produce effects: symptom, sign significantly take a turn for the better in 6 days, and blood, amylase in urine recover normal.
Effectively: symptom, sign alleviate in 6 days, and blood, amylase in urine have downward trend.
Invalid: symptom does not alleviate or worsens in 7 days, and blood, amylase in urine do not reduce.
4. therapeutic outcome:
1) every cardinal symptom improvement situation relatively sees Table 1
The table 1 liang every cardinal symptom improvement of group patient situation relatively
As seen treatment group is compared with matched group has significant difference.
2) two groups of patient APACHE-II appraisal result see Table 2
Table 2 liang group patient PACHE-II scoring
| Grouping | The 1st day | The 3rd day | The 6th day |
| The treatment group | 8.52±1.79 | 6.24±1.25 *# | 3.84±1.33 *& |
| Matched group | 8.18±2.01 | 7.89±1.71 | 6.27±1.86 * |
Annotate:
*Compared P＜0.05 with the 1st day,
#Compare P＜0.05 with the 3rd day matched group,
﹠amp;Compare P＜0.05 with the 6th day matched group.
As seen first day two groups of patient APACHE-II scoring zero difference, the treatment group was compared with first day and is had significant difference in the time of the 3rd day, in the time of the 6th day when treatment group and the 6th day matched group significant difference is arranged.
3) two groups of patients serum's amylase change, and see Table 3
Serum amylase changes relatively before and after the table 3 liang group patient treatment
Annotate: compare in the group
*P＜0.05,
*P＜0.01.
Compare between group
#P＜0.05.
By table 3 as seen: before the treatment, two groups of serum amylases similar (P〉0.05), two groups for the treatment of backs are obviously decline (P＜0.01) before the treatment all, and treatment back treatment group and matched group also have significant difference (P＜0.05), illustrate that treatment group serum amylase recovery situation is more desirable than matched group effect.
4) two groups of patients serum CRP change, and see Table 4
Change of serum C RP changes relatively before and after the table 4 liang group patient treatment
Annotate: compare in the group
*P＜0.05,
*P＜0.01.
Compare between group
#P＜0.05.
By table 3 as seen: before the treatment, two groups of change of serum C RP levels similar (P〉0.05), the two groups of CRP levels in treatment back are compared with CRP level before the treatment has utmost point significant difference (P＜0.01), and treatment back treatment group and matched group also have significant difference (P＜0.05), and visible Chinese medicine composition of the present invention can significantly reduce pancreatitis change of serum C RP level.
5) two groups of patient tumors necrosins change, and see Table 5
Tumor necrosis factor (TNF-α) changes relatively before and after the table 5 liang group patient treatment
Annotate: compare in the group
*P＜0.05;
Compare between group
#P＜0.05.
By table 5 as seen: two groups of patient treatment pre-neoplastic necrosins (TNF-α) level similar (P〉0.05), compare before treating back treatment group and treating and have significant difference (P＜0.05), and treatment back treatment group and matched group also have significant difference (P＜0.05), show that Chinese medicine composition of the present invention can reduce acute critical pancreatitis patient's tumor necrosis factor level.
6) variation of two groups of patient's urine lactulose/mannitol sees Table 6
Urine lactulose/mannitol changes before and after the table 6 liang group patient treatment
Annotate: compare in the group
*P＜0.05,
*P＜0.01.
Compare between group
#P＜0.05.
By table 6 as seen: urine lactulose/mannitol similar (P〉0.05) before two groups of patient treatments, be starkly lower than treatment preceding (P＜0.05) after the treatment for the treatment of group, has significant difference, compared in the 3rd, 6 day for two groups and have significant difference, show that Chinese medicine composition of the present invention can significantly reduce the acute critical pancreatitis patient and urinate lactulose/mannitol.
To sum up outside the test, the inventor has also carried out other development tests relevant with pancreatitis, result of study shows that Chinese medicine composition of the present invention can prevent and treat the acute pancreatitis that multiple reason causes, tumor necrosis factor (TNF-α) in the significantly release of the inflammation-inhibiting factor, reduction serum or the tissue, reduce serum amylase, lipase active, reduce pancreas coefficient and pancreatic tissue water content, suppress digestive enzyme and in the pancreas glandular cell, activate, alleviate pancreas edema and necrosis, the cellular infiltration that reduces inflammation, improve the pancreatic tissue morphological change.
The specific embodiment
Below the invention will be further described for the description by the specific embodiment, but this is not to be limitation of the present invention, those skilled in the art are according to basic thought of the present invention, can make various modifications or improvement, but only otherwise break away from basic thought of the present invention, all within the scope of the present invention.
Embodiment 1:a, take by weighing raw material Radix Scutellariae 48g, Herba Taraxaci 48g, Caulis Sargentodoxae 36g, Fructus Aurantii Immaturus 36g, Radix Bupleuri 24g, Saussurea lappa Clarke 24g, Semen Raphani 36g, Lignum Dalbergiae Odoriferae 24g, the Olibanum 24g of recipe quantity; Clean, dry;
B, with above-mentioned pulverizing medicinal materials, cross 80 mesh sieves, behind ultraviolet-sterilization, insert capsule No. 0, namely.
Embodiment 2:a, take by weighing raw material Radix Scutellariae 30g, Herba Taraxaci 30g, Caulis Sargentodoxae 30g, Fructus Aurantii Immaturus 20g, Radix Bupleuri 18g, Saussurea lappa Clarke 20g, Semen Raphani 18g, Lignum Dalbergiae Odoriferae 22g, the Olibanum 22g of recipe quantity; Clean, dry;
B, with above-mentioned pulverizing medicinal materials, cross 80 mesh sieves, behind ultraviolet-sterilization, insert capsule No. 0, namely.
Embodiment 3:a, take by weighing raw material Radix Scutellariae 60g, Herba Taraxaci 60g, Caulis Sargentodoxae 50g, Fructus Aurantii Immaturus 40g, Radix Bupleuri 38g, Saussurea lappa Clarke 40g, Semen Raphani 48g, Lignum Dalbergiae Odoriferae 46g, the Olibanum 46g of recipe quantity; Clean, dry;
B, with above-mentioned pulverizing medicinal materials, cross 80 mesh sieves, behind ultraviolet-sterilization, insert capsule No. 0, namely.
Embodiment 4:a, take by weighing raw material Radix Scutellariae 46g, Herba Taraxaci 38g, Caulis Sargentodoxae 44g, Fructus Aurantii Immaturus 28g, Radix Bupleuri 30g, Saussurea lappa Clarke 28g, Semen Raphani 32g, Lignum Dalbergiae Odoriferae 36g, the Olibanum 36 of recipe quantity; Clean, dry;
B, with above-mentioned pulverizing medicinal materials, cross 80 mesh sieves, behind ultraviolet-sterilization, insert capsule No. 0, namely.
Claims (3)
1. a Chinese medicine composition for the treatment of acute pancreatitis is characterized in that being made by the raw material of following weight portion: 48 parts of Radix Scutellariaes, 48 parts of Herba Taraxacis, 36 parts of Caulis Sargentodoxaes, 36 parts of Fructus Aurantii Immaturuss, 24 parts of Radix Bupleuri, 24 parts of Saussurea lappa Clarke, 36 parts of Semen Raphanis, 24 parts of Lignum Dalbergiae Odoriferaes, 24 parts of Olibanums.
2. the Chinese medicine composition for the treatment of acute pancreatitis as claimed in claim 1, it is characterized in that: described Chinese medicine composition is peroral dosage form.
3. the Chinese medicine composition for the treatment of acute pancreatitis as claimed in claim 2, it is characterized in that: described peroral dosage form is capsule.
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| CN104352851A (en) * | 2014-10-28 | 2015-02-18 | 匡玉华 | Chinese medicinal honeyed pills for preventing and treating pancreatitis and preparation method for Chinese medicinal honeyed pills |
| CN105395655A (en) * | 2015-11-30 | 2016-03-16 | 四川聚豪生物科技有限公司 | Decoction medicine for treating acute pancreatitis and preparation method thereof |
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| JP2987727B2 (en) * | 1992-02-05 | 1999-12-06 | 小野薬品工業株式会社 | Endogenous calcium release inhibitor containing diphenylborane derivative as active ingredient |
| JP3227673B2 (en) * | 1992-06-19 | 2001-11-12 | 味の素株式会社 | Pancreatitis prophylactic and therapeutic drugs |
| US5916922A (en) * | 1996-12-03 | 1999-06-29 | Eli Lilly And Company | Phenyl glyoxamides as SPLA2 inhibitors |
| CN1140287C (en) * | 2001-05-15 | 2004-03-03 | 王桂琼 | Oral medicine for treating spleen and stomach disease |
| CN101129556A (en) * | 2007-08-09 | 2008-02-27 | 倪慧文 | Orally taken traditional Chinese medicine for treating acute pancreatitis |
| CN101385823B (en) * | 2008-10-23 | 2011-04-27 | 上海方心科技研究所 | Medicine for treating heavy acute pancreatitis and preparation method thereof |
| CN101897837A (en) * | 2010-07-28 | 2010-12-01 | 钟弦 | Chinese medicinal composition for treating acute pancreatitis |
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Effective date of registration: 20130327 Address after: 266200, No. seven, 179 village, Wenquan Town, Jimo, Shandong, Qingdao Applicant after: Cui Xinming Address before: 276017 A302 building, Linyi hi tech Industrial Development Zone, Shandong, China Applicant before: Xu Congyu |
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Inventor after: Ma Fengcui Inventor before: Xu Jiwen |
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Free format text: CORRECT: INVENTOR; FROM: XU JIWEN TO: MA FENGCUI |
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Owner name: QIDONG SANJIANG CONSTRUCTION MACHINERY CO., LTD. Free format text: FORMER OWNER: CUI XINMING Effective date: 20140725 |
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Free format text: CORRECT: ADDRESS; FROM: 266200 QINGDAO, SHANDONG PROVINCE TO: 226200 NANTONG, JIANGSU PROVINCE |
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Effective date of registration: 20140725 Address after: 226200 Nanhai Road, Binhai Industrial Park, Nantong, Jiangsu, Qidong Patentee after: Qidong Sanjiang Construction Machinery Co., Ltd. Address before: 266200, No. seven, 179 village, Wenquan Town, Jimo, Shandong, Qingdao Patentee before: Cui Xinming |