CN102188685B - Externally-applied traditional Chinese medicine powder for treating diarrhea type irritable bowel syndrome and preparation method thereof - Google Patents
Externally-applied traditional Chinese medicine powder for treating diarrhea type irritable bowel syndrome and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an externally-applied traditional Chinese medicine powder for treating diarrhea type irritable bowel syndrome and a preparation method thereof. The externally-applied traditional Chinese medicine powder provided by the invention is prepared from the following medicinal materials in parts by weight: 50 parts of rhizome zingiberis, 20 parts of radix aconite carmichaeli, 20 parts of cinnamomum cassia, 15 parts of fructus evodiae, 15 parts of pepper, 15 parts of radix aucklandiae, 20 parts of rhizoma atractylodis, 15 parts of fructus psoraleae, 15 parts of Pomegranate Rind and 15 parts of red halloysite. The externally-applied traditional Chinese medicine powder is used for carrying out external application treatment on Shenque acupoint of 476 patients with diarrhea type irritable bowel syndrome clinically, the total effective rate is 99.2 percent, the effectual rate is 67.4 percent, and the recovery rate is 35.3 percent. No adverse effect exists.
Description
Technical field
The present invention relates to a kind of external application of Chinese medicine powder of treating diarrhea type irritable bowel syndrome, and relate to its preparation method.
Background technology
Irritable bowel syndrome is a kind ofly to change into the functional intestinal disease of characteristic with stomachache or abdominal discomfort companion bowl evacuation habit, gets rid of the organic disease that can cause these symptoms on inspection.Primary disease is modal a kind of functional intestinal tract disease.Can be divided into diarrhea-type, constipation type and alternating diarrhea and constipation type according to clinical characters.Diarrhea type irritable bowel syndrome general every day about 3～5 times, the minority serious attack phase can reach ten for several times.Stool is scattered paste shape more, also can be shaping soft stool or rare water sample.Have mucus, part patient's excrement matter is few and the mucus amount is a lot, but does not have pus and blood extremely more.Modern medicine adopts gastrointestinal antispasmodic medicine, diarrhea, antidepressants, intestinal microbial population to regulate treatment measures such as medicine and psychological behavior therapy more, though can temporarily obtain curative effect, can not solve root problem, and existing Western medicine has bigger toxic and side effects.On the other hand, present existing Chinese patent medicine ubiquity specific aim is poor, the unsafty defective of therapeutic effect.
Summary of the invention
Technical problem to be solved by this invention is, provide a kind of to diarrhea type irritable bowel syndrome have definitely, significant curative effect and the external application of Chinese medicine powder that has no adverse reaction, and the method for preparing of this Dressed medicine powder is provided.To overcome the defective of existing such disease medicine of treatment.
It is following that the present invention solves the problems of the technologies described above the technical scheme that is adopted:
A kind of external application of Chinese medicine powder of treating diarrhea type irritable bowel syndrome is characterized in that its prescription is: 50 parts of Rhizoma Zingiberiss, 20 parts of Radix Aconiti Lateralis Preparatas, 20 parts of Cortex Cinnamomis; 15 parts of Fructus Evodiaes, 15 parts in Fructus Piperis, 15 parts of the Radix Aucklandiae, 20 parts of Rhizoma Atractylodis; 15 parts of Fructus Psoraleaes, 15 parts of Pericarpium Granatis, 15 parts of Halloysitum Rubrums; Described part all refers to weight portion.
The method for preparing of the external application of Chinese medicine powder of described treatment diarrhea type irritable bowel syndrome is characterized in that being prepared from according to following steps: described prescription drugs mixes, and oven dry is ground into 80～120 order fine powders.
Rhizoma Zingiberis: nature and flavor are hot, heat.Return spleen, stomach, the heart, lung meridian.Has warming middle-JIAO, recuperating depleted YANG, the effect of warming the lung to resolve fluid-retention.Cure mainly coldness and pain in the epigastrium, vomiting dysentery, obstruction of qi in the chest and cardialgia, YANG-depletion is fainted contrary, arthralgia due to cold-dampnes, cold fluid-retention is breathed with cough.
Radix Aconiti Lateralis Preparata: nature and flavor are hot, heat; Poisonous.GUIXIN, spleen, kidney channel.Have recuperating depleted YANG and rescuing the patient from collapse, it is supporing yang to mend fire, the effect of dispersing cold for relieving pain.Be used for excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhoea is fainted contrary, the cold extremities faint pulse, trusted subordinate's cold type of pain, cold-dysentery, the beriberi edema, anemofrigid-damp arthralgia, sexual impotence, cold womb, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, the disease of carbuncle of yin nature skin infection and all chronic diseaseses.
Cortex Cinnamomi: nature and flavor are hot, sweet, heat.Return kidney, spleen, the heart, Liver Channel.It is supporing yang to have the fire of benefit, dispersing cold for relieving pain, the effect of promoting the flow of QI-blood by warming the meridian.The mainly treating intolerance of cold cold extremities, soreness of the waist and knees, sexual impotence, frequent micturition, coldness and pain in the epigastrium, arthralgia due to cold-dampnes, deficiency and coldness is vomited and diarrhoea, amenorrhea, dysmenorrhea, carbuncle of yin nature multiple abscess or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus, or do not hold back after bursting.
Fructus Evodiae: nature and flavor are hot, bitter, heat; Slightly poisonous.Return liver, spleen, stomach warp.Has dispersing cold for relieving pain, the soothing the liver therapeutic method to keep the adverse QI flowing downwards, the effect of dampness.Cure mainly coldness and pain in the epigastrium, colic, headache due to JUE YIN disorder, deficiency and coldness is had loose bowels, vomiting acid regurgitation, cards such as the disturbance of lower legs due to pathogenic cold and dampness.
Fructus Piperis: nature and flavor are hot, hot.Return stomach, large intestine channel.Effect with warming middle-JIAO to relieve pain.Be used for the intestines and stomach have cold, epigastric pain, the vomiting have loose bowels.
The Radix Aucklandiae: nature and flavor are hot, bitter, temperature.Return spleen, stomach, large intestine, gallbladder meridian.Have circulation of qi promoting, in the accent, the analgesic effect.Be used for inappetence, accumulation of food in the stomach and intes tine due to indigestion, abdominal distention, increased borborygmus and diarrhea and dysentery stomachache, tenesmus due to the stagnation of QI in spleen and stomach; The hypochondriac pain bitter taste that QI stagnation of the liver and galibladder causes; Weakness of the spleen and stomach, fortuneization is unable, cards such as distension and fullness in the abdomen, vomiting and diarrhoea.
Rhizoma Atractylodis: nature and flavor are hot, bitter, temperature.Return spleen, stomach warp.Have drying damp and strengthening spleen, the effect of wind-damp dispelling.Curing mainly wet the Sheng and being stranded spleen, the asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, nausea and vomiting is had loose bowels, anemofrigid-damp arthralgia, foot swelling and pain in knee, flaccidity are soft unable, nyctalopia etc.
Fructus Psoraleae: nature and flavor are bitter, hot, big temperature.Return kidney, spleen channel.Has kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha effect.Cure mainly sexual impotence, chills and pain of the waist and kness, spermatorrhea, the enuresis, frequent micturition, the having loose bowels of deficiency of spleen-YANG and kidneyYANG.
Pericarpium Granati: nature and flavor acid, puckery, temperature.Return large intestine, stomach warp.Has relieving diarrhea with astringents, parasiticidal effect.Cure mainly chronic diarrhea, chronic dysentery, proctoptosis, cards such as abdominal pain due to worm stagnation.
Halloysitum Rubrum: nature and flavor are sweet, sour, puckery, temperature.Return stomach, large intestine channel.Has relieving diarrhea with astringents, the hemostatic effect; External astringent therapy granulation promoting is held back skin ulcer.Cure mainly unconsolidation of lower-JIAO, dysentery is more than, the proctoptosis of having blood in stool, bleeding not during menses, ulcer being unable to heal, eczema flowing water, traumatic hemorrhage etc.
Good effect of the present invention is: all medicines share, and can play warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain, and the effect of relieving diarrhea with astringents, thus make diarrhea type irritable bowel syndrome (traditional Chinese medical science belongs to " having loose bowels " category) reach therapeutic purposes.
476 routine diarrhea type irritable bowel syndrome patients are carried out the SHENQUE acupoint external application for curing, total effective rate 99.2%, obvious effective rate 67.4%, cure rate 35.3% through clinical.Do not see untoward reaction.
The specific embodiment
Further specify the present invention below in conjunction with instantiation and clinical experiment report.
The prescription instance:
Prescription example one
Prescription: 50 parts of Rhizoma Zingiberiss, 20 parts of Radix Aconiti Lateralis Preparatas, 20 parts of Cortex Cinnamomis, 15 parts of Fructus Evodiaes, 15 parts in Fructus Piperis, 15 parts of the Radix Aucklandiae, 20 parts of Rhizoma Atractylodis, 15 parts of Fructus Psoraleaes, 15 parts of Pericarpium Granatis, 15 parts of Halloysitum Rubrums; Described part all refers to weight portion.
Method for preparing: described prescription drugs mixes, and oven dry is ground into 80～120 order fine powders.
It below is clinical data
From year January in August, 2007 to 2011; The inventor uses the write out a prescription Chinese powder medicine of example one preparation of the present invention 476 routine diarrhea type irritable bowel syndrome patients is carried out the SHENQUE acupoint external application for curing in the hospital of traditional Chinese hospital, Yantai; And with using Spleen Invigorating and Intestine Tonifying Pill the same period (Guangzhou Chenliji Pharmaceutical Factory produces; The accurate word Z44023376 of traditional Chinese medicines) treatment 476 routine diarrhea type irritable bowel syndrome patients carry out controlled observation, have significant difference, and existing report as follows.
(I), clinical data
All cases are the out-patient of the hospital of traditional Chinese hospital, Yantai; Meet the up-to-date Rome III diagnostic criteria of the 7th edition diarrhea type irritable bowel syndrome of national higher medical universities and colleges' state-compiled textbooks " internal medicine ": (1) course of disease half a year is above and continue to exist abdominal discomfort or stomachache over nearly 3 months, and with in the following characteristics at least 2: 1. symptom is improved behind defecation; 2. symptom follows defecation frequency to change; 3. the change of companion's feces character takes place in symptom.(2) following symptom is not that diagnosis institute is indispensable, but belongs to common sympton, the many more diagnosis of supporting irritable bowel syndrome more of these symptoms: 1. stool unusual (every day defecation＞3 times); Feces character unusual (scattered paste shape, shaping soft stool or rare water sample); 3. feces discharge process unusual (sense of urgency, defecation are felt not to the utmost); 4. mucus just; 5. flatulence or abdominal distension sense.(3) morphological change that lacks soluble symptom is with biochemical unusual.Get rid of organic diseases such as tumor, ulcerative colitis, crohn.Totally 952 examples are divided into two groups at random by prescription on individual diagnosis sequence number (1: 1), and 476 examples are organized in treatment, wherein male 248 examples, women 228 examples; Age is 14-72 year (average 40 years old); Course of disease half a year-20 year (average 12 years); Matched group 476 examples, male 244 examples, women 232 examples; Age 13-70 year (average 38 years old); Course of disease half a year-20 year (average 12 years).Two groups of ages, sex, the course of disease are through statistical procedures, and there was no significant difference has comparability (P＞0.05).
(II), Therapeutic Method
1, therapeutic scheme
(1) treatment group
With 50 parts of Rhizoma Zingiberiss, 20 parts of Radix Aconiti Lateralis Preparatas, 20 parts of Cortex Cinnamomis, 15 parts of Fructus Evodiaes, 15 parts in Fructus Piperis, 15 parts of the Radix Aucklandiae, 20 parts of Rhizoma Atractylodis, 15 parts of Fructus Psoraleaes, 15 parts of Pericarpium Granatis, 15 parts of Halloysitum Rubrums.
All medicines mix, and oven dry is ground into 80～120 order fine powders.The patient gets dorsal position, and medicated powder is spread on the SHENQUE acupoint, fixes with medical proof fabric, takes off medicine after continuing to apply ointment or plaster 3 days, changes new drug again, sticked continuously 12 days, and be a course of treatment, have three days off, continue next course of treatment.Add up curative effect after treating 3 courses of treatment.Inactive other any medicines during the treatment.
(2) matched group: oral Spleen Invigorating and Intestine Tonifying Pill, each 6 grams, every day three times.Take the course of treatment with the treatment group.
(III), observation of curative effect
1, efficacy assessment standard:, obtain therapeutic index according to the total score value of cardinal symptom (being each item symptom integral sum) with reference to " new Chinese medicine clinical research guideline (trying) ".The total score value of cardinal symptom * 100% before therapeutic index=(the total score value of cardinal symptom before the treatment-total score value of treatment back cardinal symptom)/treatment.Recovery from illness: cardinal symptom disappears, and stool is shaped, and mucus disappears, therapeutic index 100%; Produce effects: cardinal symptom disappears basically, and stool is approximate to be shaped, and mucus obviously reduces, therapeutic index >=75%; Effectively: cardinal symptom takes a turn for the better, and it is still half congealed defecate, the mucus minimizing, therapeutic index >=30% but＜75%; Invalid: clinical symptoms does not have improvement, therapeutic index＜30%.Cardinal symptom (comprise stomachache, abdominal distention, defecation frequency, defecation feel not to the utmost, defecates character etc.) integration variation before and after the treatment.The cardinal symptom grading is with reference to " new Chinese medicine clinical research guideline (try) ", by do not have, 4 grades of slight, moderates, severe 0～3 minute, asymptomatic long-pending 0 minute, slightly long-pending 1 minute, long-pending 2 minutes of moderate, severe is amassed 3 fens.
2, statistical method: all data are analyzed with the Spss10.0 statistical software, and effective percentage is relatively used x
2Check, the symptom score is relatively checked with t.
3, therapeutic outcome
(1) two group of clinical efficacy is relatively seen table 1.
Table 1 liang group clinical efficacy relatively
Two groups of curative effects compare P＜0.05, and prompting treatment group curative effect is superior to matched group.
Table 2 is relatively seen in the variation of cardinal symptom integration before and after (2) two groups of treatments.
The cardinal symptom integration changes relatively
before and after the table 2 liang group treatment
| Group | The example number | Before the treatment | After the treatment | Difference |
| The treatment group | 476 | 9.12±0.23 | 3.43±0.56 | 5.72±0.21 |
| Matched group | 476 | 9.17±0.22 | 5.28±0.36 | 3.47±0.36 |
Two groups of treatment back cardinal symptoms all have clear improvement, and relatively preceding with treatment, difference has significance meaning (P＜0.05); Relatively, difference also has statistical significance (P＜0.05) after treatment group and the treatment of control group, and prompting treatment group doing well,improving degree is better than matched group.
4, untoward reaction: do not see untoward reaction.
Claims (2)
1. an external application of Chinese medicine powder of treating diarrhea type irritable bowel syndrome is characterized in that its prescription is: 50 parts of Rhizoma Zingiberiss, 20 parts of Radix Aconiti Lateralis Preparatas, 20 parts of Cortex Cinnamomis; 15 parts of Fructus Evodiaes, 15 parts in Fructus Piperis, 15 parts of the Radix Aucklandiae, 20 parts of Rhizoma Atractylodis; 15 parts of Fructus Psoraleaes, 15 parts of Pericarpium Granatis, 15 parts of Halloysitum Rubrums; Described part all refers to weight portion.
2. the method for preparing of the external application of Chinese medicine powder of the described treatment diarrhea type irritable bowel syndrome of claim 1 is characterized in that being prepared from according to following steps: described prescription drugs mixes, and oven dry is ground into 80～120 order fine powders.
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| CN103127487A (en) * | 2013-03-19 | 2013-06-05 | 刘华荣 | Traditional Chinese medicine compound for treatment of diarrhea after brain surgery |
| CN103705891A (en) * | 2013-12-30 | 2014-04-09 | 南阳医学高等专科学校 | Traditional Chinese medicine preparation for treating diarrhea-predominant pattern irritable bowel syndrome |
| CN103784665B (en) * | 2014-02-12 | 2016-01-20 | 张燕 | Alleviate Chinese medicine preparation of irritable bowel syndrome and preparation method thereof |
| CN104208352A (en) * | 2014-09-04 | 2014-12-17 | 刘军 | Medicine-separated navel moxibustion traditional Chinese medicine composition for treating diarrhea-dominant irritable bowel syndrome |
| CN105663968A (en) * | 2016-04-09 | 2016-06-15 | 乔兴友 | Traditional Chinese medicine composition for treating spleen-kidney yang deficiency type irritable bowel syndrome |
| CN107890558A (en) * | 2017-12-22 | 2018-04-10 | 裴虎雷 | A kind of Chinese medicine composition for treating infantile diarrhea and preparation method thereof |
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| 任中宝.93例慢性结肠炎患者临床治疗效果观察.《中外医疗》.2009,(第36期),32. * |
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