CN104940241B - A kind of selenium worm grass compound preparation of prevention climacteric metancholia of women - Google Patents
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Abstract
A kind of selenium worm grass compound preparation of prevention climacteric metancholia of women of the present invention, it is characterised in that the selenium worm grass compound preparation for preventing climacteric metancholia of women includes selenium worm grass Ultramicro-powder, isoflavones and procyanidine.A kind of selenium worm grass compound preparation of prevention climacteric metancholia of women of the present invention can prevent and treat female climacteric syndrome；Pre- anti-osteoporosis；Beautifying face and moistering lotion, anti aging effect；Adjust immune function；Prevent senile dementia.
Description
Technical field
The present invention relates to the selenium worm grass compound preparation of prevention climacteric metancholia of women, the especially preventions of health care of women
The selenium worm grass compound preparation of climacteric metancholia of women.
Background technology
Female climacteric syndrome be female ovary function gradually decline to the transition period completely disappeared, due to physiology and
Psychology changes and a series of clinical symptoms for occurring, common to warm sweating, irritable, palpitation and insomnia or melancholy forgetful etc..
According to clinical manifestation, this disease belongs to the scope of " menopausal disorders " of traditional Chinese medicine.The occurrence of this disease is women after premenopausal,
A virtual loss is appointed in the gradual failure of kidney qi, punching, and asthenia of essence and blood, menses is gradually exhausted, and menstruation will be disconnected and physiological change that the menopause that arrives occurs, but have
A little women are not adapted to these physiological changes for the moment, negative and positive are made to lose due to the influence of constitution or mental element and other factors
It goes to balance, internal organs qi and blood functional disturbance and a series of syndrome of viscera functions disorder that occurs.
Modern medicine believes that, climacteric syndrome is the decrease in estrogen, interior point because after female ovary deterioration
Secrete imbalance caused by it is a series of based on function disorder of autonomic nervous system, with the syndrome of neuropsychological symptom.Namely
Say, the basic reason of climacteric syndrome is aging and causes hypo-ovaria, by the organ that estrogen controls and dominates and
Retrogression pathological changes occur for tissue.Aging be biology over time, spontaneous necessary process.The free-radical theory of aging is recognized
For the aging of cell is harmful substance and the result of free radical accumulation in endocellular metabolism.
Free radical is some molecules or atomic group of human body metabolism's process, is contained thereon there are one unpaired electron, free
Base can make the lipid molecular peroxidating in biomembrane (such as cell membrane) and electrically charged, its structure is made to become dumb, thereon by
Body can not play a role, and normal vital movement is caused to get muddled, and cause disease；Worse, lipid molecular is by peroxidating
Afterwards, it may occur that after peroxidating, thousands upon thousands molecule continuation can be aoxidized, caused to human body for chain reaction, a molecule
Serious damage.With the further investigation to free radical and disease relationship, it is now recognized that have more than 70 kinds of disease related with free radical, including
Heart disease, artery sclerosis, arthritis, allergy, cataract, senile dementia, menopausal syndrome, coronary heart disease and cancer.Free radical
Biomembrane and other tissues are caused to damage, cumulative Free Radical can lead to body aging, and cause a series of disease
Reason process.
Body will produce free radical in normal metabolic processes, while can be removed at any time by body antioxidant system, no
Its aggregation is set to be detrimental to health.Decline when free radical generates excessive or Scavenging activity, human body cannot maintain free radical to produce
The raw dynamic equilibrium between removing so that have excessive free radical accumulation in human body.Excessive free radical can cause carefully
After birth lipid oxidation, the product MDA of lipid peroxidation, also results in intracellular nucleic Acid denaturation and dysfunction, when these detriments
Body just develops to aging when accumulation.At 25 years old, " eliminating oxygen radical substance " in human body was most abundant, gradually subtracts later
It is few, 40 years old has been spent, speed has been reduced and accelerates to be especially living environment and social environment jumpy so that the machine of most of crowds
The ability for generating free radicals scavenger in vivo is gradually reduced, and is caused the content of internal scavenger to reduce activity and is gradually lowered, from
And the defence capability to free radical damage is weakened, it is (or anti-oxidant such as from external supplement to eliminate oxygen radical substance not in time
Agent), human body is easy for being infested with all diseases, quickly aging, dead.
Women reduces bone density, more with 5~6% speed after climacteric with 1% speed every year after 35 years old
It is lost in sclerotin.Incretory (especially sexual gland) start gradually to degenerate after women 35 years old, and involutional various symptoms occur.Dimension
The antioxidant and free radical scavenger level for holding internal proper level can extend service life and delay aging.In body there is
Free-radical ring opening polymerization can defend the damage of free radical to the maximum extent.Glutathione peroxidase (GSH-PX) is body
Interior most important antioxidase, vitamin c, vitamin e, selenium, procyanidine are free radical scavengers.
Invention content
The problem to be solved in the present invention is to prevent and treat female climacteric syndrome；Pre- anti-osteoporosis；It is beautiful
Hold beauty treatment, anti aging effect；Adjust immune function；Prevent senile dementia.
A kind of selenium worm grass compound preparation of prevention climacteric metancholia of women of the present invention, it is characterised in that prevention women's climacteric
The selenium worm grass compound preparation of phase syndrome includes selenium worm grass Ultramicro-powder, isoflavones and procyanidine.
The invention discloses a kind of selenium worm grass compound preparations of prevention climacteric metancholia of women, it is characterised in that described
It prevents in the selenium worm grass compound preparation of climacteric metancholia of women and also contains isomaltoketose.
The invention discloses a kind of selenium worm grass compound preparations of prevention climacteric metancholia of women, it is characterised in that described
The selenium worm grass compound preparation of climacteric metancholia of women is prevented by selenium worm grass Ultramicro-powder 0.3g, isoflavones 50mg, former cyanine
Plain 50mg and isomaltoketose 0.1g compositions, the selenium worm grass compound preparation every of the prevention climacteric metancholia of women
0.5g。
The invention discloses a kind of selenium worm grass compound preparations of prevention climacteric metancholia of women, it is characterised in that described
Prevent every 30 microgram containing selenium in the selenium worm grass compound preparation of climacteric metancholia of women.
The invention discloses a kind of selenium worm grass compound preparations of prevention climacteric metancholia of women, it is characterised in that described
The selenium worm grass compound preparation processing method for preventing climacteric metancholia of women is by the Ultramicro-powder of 300 mesh of selenium worm grass and the different Huang of soybean
Ketone, procyanidine and isomaltoketose are uniformly mixed, then are granulated, and raw material drying is tabletted to amount containing water≤6%.
A kind of selenium worm grass compound preparation of prevention climacteric metancholia of women of the present invention can prevent and treat women climacteric
Phase syndrome；Pre- anti-osteoporosis；Beautifying face and moistering lotion, anti aging effect；Adjust immune function；Prevent senile dementia.
A kind of selenium worm grass compound preparation suitable population of prevention climacteric metancholia of women of the present invention：35 years old or more women.
According to the understanding to female ovary deterioration, the women of one's mid-30s begins to need to take this product.It was taken before 40 years old small
Dosage, 41-50 Sui should use sufficient dosage, need large dose oral administration after 50 years old；There is menopause symptom person's dosage that must increase,
Dosage size is adjusted according to personal feeling and somatic reaction.
A kind of selenium worm grass compound preparation instructions of taking of prevention climacteric metancholia of women of the present invention：The right side of fifty is without climacteric
Phase symptom daily health caring takes 1 daily, takes 2 daily without menopause symptom daily health caring within 50 years old or more, takes 3-4 every year
A month；It takes 3 months, takes every year later 3-4 months after thering is the daily 2-3 pieces of menopause symptom, symptom to disappear.Taboo：Pregnant woman
Avoid use with women breast-feeding their children.
The present invention it is a kind of prevention climacteric metancholia of women selenium worm grass compound preparation be using raw material：
Selenium worm grass：Cordyceps sinensis and ginseng, pilose antler are eponymous, are known as Chinese medicine Triratna, as drug and health products using
There is centuries history, and is recognized and received extensively by people.Selenium worm grass remove containing the intrinsic cordycepin of general cordyceps sinensis, cordycepic acid,
Outside the functional components such as Cordyceps sinensis polysaccharide, it is also rich in important biological element-selenium.
Natural cs it has been reported that more than 300 kinds, distribution in China it is most wide be cordyceps sinensis and Cordceps militaris.Cordyceps sinensis is
It is well known, Cordceps militaris is the abbreviation of northern Chinese caterpillar Fungus, is also Cordyceps militaris or pupa grass, the not old grass of popular name.It is that worm, bacterium combine
Medicinal fungi, modern Valuable Herbal Medicine.Northern Chinese caterpillar Fungus belongs to Eumycota, Ascomycetes, Hypocreales, Clavicipitaceae, cordyceps sinensis
Belong to.It is mainly grown in the northern area in China.Cordceps militaris not only contains abundant protein and amino acid, but also contains more than 30
The trace element of kind of needed by human body is first-class excellent tonic product.There is similar function with cordyceps sinensis.Due to wild worm
For grass by a large amount of diggings, resource several exhaustion, prices to the greatest extent are extremely expensive.Therefore people have widely carried out tasting for artificial aweto cultivation
Examination, the cordyceps mycelia of tank fermentation method production at present, artificial culture Cordyceps militaris fruiting body have succeeded, and Cordceps militaris is
Through being approved as new resource food by the Ministry of Public Health.Selenium worm grass is the northern Chinese caterpillar Fungus for selecting poly- selenium ability especially strong by holy peak medicine company
Strain, using natural selenium resource of bestowing favour as the selenium source of culture medium, using modern biotechnology tissue culture technology, through taming repeatedly and biology
Conversion, makes inorganic selenium pass through the decomposition of Cordyceps Militaris, absorb, be converted to the Organic Selenium cordyceps militaris sporocarp being easily immediately used by the body, makes worm
The effective ingredient of grass is combined with the effect of Organic Selenium, to play better biological action.
International and domestic many research units are to natural cordyceps and Cordceps militaris (artificial culture) functional component, trace element
And amino acid content is analyzed, holy peak medicine company commission Guangzhou Institute of Analysis, Zhongshan city sanitary inspection center, west place in Hubei
Southern agricultural and sideline product Supervision Test Center, bureau of geology and mineral resources of Hubei Province units such as laboratory of bestowing favour have carried out related point to selenium worm grass
Analysis.The results show that the Cordceps militaris of artificial culture, selenium worm grass be compared with natural cordyceps, three organic and inorganic nutrients at
It is almost the same in point type, but the Cordceps militaris of artificial culture, selenium worm grass are higher than the natural winter worm summer in main functional component content
Careless several times to tens times (table 1, table 2, tables 3).If the distinctive functional component cordycepin of cordyceps sinensis is higher by 35--59 times, adenosine is higher by
4--5 times.Se content in selenium worm grass is even more hundred times of cordyceps sinensis and Cordceps militaris.And selenium in cordyceps sinensis mainly with Organic Selenium shape
Formula exists, and is counted through 6 batch sample measurement results, and organic selenium content averagely accounts for 94.80% (91.67%--- of total selenium
97.82%).50% or more selenium in cordyceps sinensis is combined with protein, and (relaxation 2009) is combined secondly with polysaccharide.To evaluate selenium worm grass
Safety has also carried out toxicological experiment, and Disease Prevention Control Center, Hubei Prov is with chmice acute Oral toxicity experimental result table
It is bright：The experiment of selenium worm grass fructification powder acute oral toxicity belongs to nontoxic grade.
The functional component (%) of the different cordyceps sinensis of table 1
| Sample ID | Adenosine | Cordycepin | Cordycepic acid | Polysaccharide | Amino acid | Protein |
| Natural cs # | 0.05 | 0.01 | 11.28 | 3.95 | 21.49 | 30.19 |
| Artificial cordyceps # | 0.21 | 0.35 | 12.00 | 4.48 | 19.10 | 43.72 |
| Selenium worm grass * | 0.26 | 0.59 | 6.70 | 2.50 | 18.27 | 25.30 |
Note：# is China Academy Of Traditional Chinese Medicine Traditional Chinese Medicine Research Institute's testing result
* it is that spectrum Buddhist nun tests scientific and technological (Beijing) testing result
The micronutrient levels 9 (ug/g) of the different cordyceps sinensis of table 2
| Sample ID | Selenium | Zinc | Iron | Lead | Arsenic |
| Natural cs # | 0.325 | 98.99 | 959.1 | 0.217 | 6.991 |
| Artificial cordyceps # | 0.302 | 88.55 | 82.02 | 0.101 | 0.259 |
| Selenium worm grass * | 30---50 | 92.5 | 85.00 | 0.010 | ≥0.005 |
Note：# is Chinese Academy of Sciences's Beijing physical and chemical testing Spot detection result
* it is that spectrum Buddhist nun tests scientific and technological (Beijing) testing result
The amino acid content (g/100g) of the different cordyceps sinensis of table 3
Note：# is Beijing City Nutrient Source Inst testing result
* it is that spectrum Buddhist nun tests scientific and technological (Beijing) testing result
Selenium is micro- necessary to humans and animals life, and symbol of element Se is had found, selenium for 1817 by Berzhus
The abundance present in nature is the 70th in chemical element, and selenium is compared with its congeners sulphur, containing in the earth's crust
Much less is measured, content is only 5/1000000ths of earth crustal mass.And distributed pole is inhomogenous, existing high selenium zone, and presence in the world
A wide range of selenium deficiency environment.It is the whole world is found earliest and high selenium zone maximum so far to bestow favour.Selenium-rich of bestowing favour resource
In, selenium derives from bone coal, and bone coal converts inorganic selenium after root system of plant and blade absorption through burning and breaking up into soil and water
For Organic Selenium.The data that WHO is announced shows that there is more than 40 country in the whole world, and China has 72% county (city) to belong to low selenium and selenium deficiency
There are Keshan disease, Kaschin-Beck disease, certain cancers in area, the serious selenium deficiency area such as Heilungkiang, the Inner Mongol, Gansu, Qinghai, Sichuan
District occurred frequently (such as Jiangsu Qidong City) areas Ye Shudixi.
1973, WHO and international nutritive issue confirmed that selenium is behaved and necessary trace element in animal body.The nutrition master of selenium
If especially being combined with zymoprotein by protein and playing antioxidation.Selenium has association with other trace elements, vitamin
Same-action, such as selenium cooperate with zinc, copper and vitamin E, vitamin C, vitamin A, carrotene and remove internal metabolic waste ---
Free radical.Selenium has antagonism to some metal toxic elements (such as cadmium, mercury, arsenic, thallium)；Selenium can prevent fusarium toxin (T-
2) to the damage of cardiac muscle cell, liver cell and cartilage cell；Selenium can be antiviral, to strong carcinogen --- aflatoxin B1
(AFB1) the non-program synthesis of leucocyte DNA induced has blocking effect, and hepatitis B can be prevented to develop into liver cancer；Selenium has adjusting
And the effect of immune function of human body is improved, make human body specific immunity and nospecific immunity, humoral immunity and cellular immunity work(
Relative balance state can be in；Selenium has anti-aging effects, and experimental animal can be made to extend the service life, and has antifatigue effect；Selenium has
Radiation resistance can effectively mitigate the toxic side effect of cancer Radiotherapy chemotherapy, increase the dosage of anticarcinogen, be conducive to controlling for cancer
It treats；Selenium can protect eyesight, prevention to occur, and can inhibit the peroxide injury of eye lens.Selenium also has one in hereditary field
The ground of seat, in recent years studies have shown that selenium participate in vivo protein, enzyme and coenzyme synthesis, selenium --- cysteine (Se-cys)
It is the 21st amino acid of genetic code normal encoding.
Selenium, which is applied to clinical treatment, mainly 5 effects, i.e. antimutagenic effect, antioxidation, the carcinogenic body of promotion
Interior deactivation, suppressing cell reproduction effect, enhancing immunity of organism force effect.Selenium has with more than 40 kinds of common diseases directly or indirectly to close
System.Selenium-supply can effectively prevent Keshan disease, effectively prevent Kaschin-Beck disease, and selenium-supply can make liver cancer incidence decline 35%, make have liver cancer
Family history person's incidence declines 50%, and selenium-supply can the biography of inhibition of hepatitis b virus carrier generation liver cancer and hepatitis B in crowd
Broadcast and improve immune function of human body.Selenium deficiency is the pathogenetic major reason of coronary disease, and WHO and International Atomic energy association are classified as selenium
One of five kinds of elements related with coronary heart disease are studied.Selenium is an ideal co-adjuvant in chemotherapy of tumors, can be apparent
Gastrointestinal reaction, haematics toxicity, renal toxicity, the cardiac damage etc. for mitigating anticancer drug, to which the dosage that chemotherapy can be improved is strong
Degree.In clinical treatment and in preventing, Organic Selenium is higher than the bioavailability of inorganic selenium, and the residence time is long in vivo, is conducive to machine
Body establishes stable selenium deposit, and small toxicity.For normal person per 50-250ug of complementary diets selenium day by day, tumour patient recommends 300-
400ug.Mo Yizeng etc. observes influence of the selenium worm grass to concurrent chemoradiotherapy of malignant tumor patient immune function and life quality, it was demonstrated that selenium
Cordyceps sinensis cooperation chemicotherapy can be such that peripheral blood CD3, CD4 increases, and can also mitigate patient symptom.Show that selenium worm grass can improve evil
Property tumor chemoradiotherapy patient immune function, improve life in patients.
Cordycepin has the function of broad-spectrum antiseptic, it can inhibit streptococcus, Actinobacillus mallei, bacillus anthracis, pig hemorrhagic to lose
The growth of the pathogens such as mass formed by blood stasis bacillus and staphylococcus.In addition, cordycepin is to gypsum sample little gemma tinea bacterium, the small gemma tinea of ulotrichy
The skin pathogenicities such as bacterium, trichophyton mentagrophytes fungi and hay bacillus also have inhibiting effect.Sugar, which demonstrates cordycepin, to be had very
Strong antifungal activity.
Cordycepin also has stronger antiviral activity.The study found that cordyceps sinensis is known as anti-herpesvirus DeJulian-
Ortiz and inhibit encephalitis viruses function, to human immunodeficiency type virus HIV-I types infect and its activity of reverse transcriptase
Also there is inhibiting effect.Further investigation finds that cordycepin can inhibit the duplication of c-type RNA oncorna virus, can also effectively inhibit disease
The synthesis of the mRNA and polyadenylic acid of poison, can hinder the BALB/3T3 and BALB/K- that are induced by 5-I-2'- BrdUs
The murine leukemia virus that 3T3 cells generate.
Isoflavones：Isoflavones is flavone compound, is a kind of cometabolism production formed in soybean growth
Object is a kind of bioactive substance.Due to being extracted from plant, there is similar structure to estrogen, therefore isoflavones is again
Claim phytoestrogen.
It is many research shows that isoflavones have delaying female aging, improve menopause symptom, osteoporosis, blood fat liter
The effects that height, breast cancer, prostate cancer, heart disease, osteoporosis, angiocardiopathy.Isoflavones can replace estrogen with
ER, which is combined, plays estrogen-like action, and estrogen can be interfered to be combined with ER, shows as the effect of antiestrogenic sample.Isoflavones
Display estrogenic activity or antiestrogenic depend primarily on the hormone metabolism state of study subject itself.To high estrogen water
Flat person shows antiestrogenic such as the animal and young woman of young animals and estrogen；It is relatively low to estrogen level
Person shows estrogenic activity such as brood, removal ovary animal, menopausal women.The estrogen-like action of isoflavones is to old
Year women's many and Hormone Withdrawal move back relevant disease such as menopausal syndrome, blood fat increase, atherosclerosis and osteoporosis
Deng there is certain preventive and therapeutic action.The estrogenic effect of isoflavones can moisten the important sexual organ of women ---
Vagina increases sexual gland secretion, thickens vagina epithelium, so that women vagina muscles elasticity is enhanced, to improve life quality.
Women ovulation in 20 years old to 25 years old about ten to 12 times every year, later women is often only ovum within 40 years old
Seven, subtract again after eight times, 5 years until ovulation terminates.As ovulation is reduced and is terminated, women estrogen level continuously decreases, according to
To the understanding of female ovary deterioration, the women of one's mid-30s begins to need to take isoflavones.Small dose was taken before 40 years old
Amount, 41-50 Sui should use sufficient dosage, need large dose oral administration after 50 years old；There is menopause symptom person's dosage that must increase, root
Dosage size is adjusted according to personal feeling and somatic reaction.
Isoflavones is applied in this preparation, is the characteristic for having similar structure to estrogen using it, by supplementing women
Exogenous plant estrogen, Hormone Withdrawal caused by solving ovarian failure move back relevant disease such as menopausal syndrome, blood fat liter
The problems such as high, atherosclerosis and osteoporosis.
Procyanidine：Procyanidine (Proanthocyanidins, PC) also has extremely strong anti-oxidant, elimination free radical
Effect, ultra-oxygen anion free radical and hydroxyl radical free radical can be effectively eliminated, also assist in phosphoric acid, arachidonic metabolism and egg
White matter phosphorylation, protects lipid that peroxide injury does not occur；Strong metal-chelator, can chelated metal ions, in body
Interior formation inert compound；Protection and stable vitamin c, contribute to the absorption and utilization of vitamin c.For skin, its energy
Restore activity of collagen, keeps skin smooth and flexible.Collagen is the fundamental component of skin, and to be one kind making us
Body becomes the colloid substance of an entirety.Vitamin C is the biochemical synthesis necessary nutriment of collagen.Procyanidine makes more
More vitamin Cs comes into force, which means that vitamin C can more easily go to complete functional (the including collagen production of its institute
It is raw).Procyanidine is connected on collagen, those can be prevented to destroy the harm of the enzyme of collagen.Procyanidine is not only
It helps collagen fabric to form cross-linked structure, and can help to restore excessive crosslinked caused by injured and free radical
Damage.Excessively crosslinking can make connective tissue suffocate and harden, to make skin corrugate and premature aging.Therefore anthocyanidin has
Anti-aging uvioresistant, radioresistance, brightens, moisturizing and other effects.
Procyanidine can mitigate premenstrual (anxiety) syndrome and menopausal syndrome symptom of women.Because hormone loses
Balance, brain, ovary and uterus cannot get enough oxygen.Will appear on psychological and body various diseases perhaps such as have a pain in the back,
Abdomen swells, muscle cramp, personality variation (such as fly into a rage, fly into a rage, or even want to commit suiside), depression, fatigue, syncope, insomnia,
Arthralgia, headache, urinary tract infections.Procyanidine can strengthen capillary, artery and vein blood vessel, improve blood circulation.Cause
This, it has the effect of detumescenceization silt.The drag reduction and permeability of capillary improve, and cell is made to be easier to absorb nutrient and row
Except waste.Therefore, procyanidine removes anti-oxidation function, can in scavenger-cell film except water-soluble and fat-soluble free radical,
It is also prevention menopausal syndrome, the mechanism of action of anti-aging to improve blood circulation.
Isomaltoketose：White crystals, odorless, sweet, sugariness are about the 42% of sucrose, and sweet taste is pure, basic with sucrose
Identical, without bad rear taste, 122~124 DEG C of fusing point, 20D97.2 ° of specific rotatory power (α) is acidproof, heat-resisting, and (20% is not molten for facile hydrolysis
Liquid 100 DEG C of heating 60min in pH2.0 are not decomposed still, and sucrose can be hydrolyzed all under similarity condition) thermal stability compares sucrose
Low, soluble easily in water, the viscosity of aqueous solution is also more slightly lower than the sucrose of comparable sodium.This product can be digested in enteron aisle, by body
It is absorbed and utilized.Blood glucose value is influenced less, it will not saprodontia.Isomaltoketose is a kind of day found in the products such as sugarcane, honey
Right carbohydrate, since it has the function that will not cause decayed tooth.Whole world numerous studies and exploitation, is widely used in various food
In sweetener.The function and application of isomaltoketose developed always successively.Such as latest find it to human body brain
Especially there is specific functionality；It is also a kind of special sweetener, there is unique digestion and absorbability.It is highly suitable to be applied for sugar
In fruit, beverage and various food.Because isomaltoketose is digested absorb after will not cause the secretion of insulin, would not also draw
Play the active activations of LPL.So the presence of isomaltoketose makes grease be not easy to be absorbed into adipose tissue.
First by 300 purpose of selenium worm grass when a kind of selenium worm grass compound preparation of prevention climacteric metancholia of women of the present invention uses
Ultramicro-powder is uniformly mixed with isoflavones, procyanidine and isomaltoketose, then is granulated, by raw material drying to amount containing water≤
6% is tabletted.
A kind of selenium worm grass compound preparation of prevention climacteric metancholia of women of the present invention, cordyceps sinensis is in special ecology
With formed under extreme environment, it possesses special gene and expression product and character, be the precious genetic resource of the mankind.
The selenium worm grass that Hubei Shengfeng Drug Co., Ltd. is cultivated using local abundant natural selenium resource through studying for many years, by cordyceps sinensis
The effect of and the effect of selenium be combined into one.Good cordyceps sinensis gene is allowed to obtain perfect expressions in the product.Cause
This can consider：Selenium worm grass is derived from cordyceps sinensis, and work(is both health partner and disease and the inferior health group of successful personage in cordyceps sinensis
Body best nutritional invigorant.
A kind of use of the selenium worm grass compound preparation of prevention climacteric metancholia of women of the present invention：
To voluntarily taking the menopausal syndrome patient of selenium worm grass soybean isoflavones capsules during in December, 2014 in 2010
Data is counted, and the clinical efficacy with selenium worm grass soybean isoflavones capsules treatment menopausal syndrome is inquired into.
Complete data person totally 98, age are 44-55 years old (being averaged 49.2 years old), and the course of disease (is averaged 14.2 for 3 months to 3 years
Month).Diagnosis and curative effect reference《New Chinese medicine guideline of clinical investigations》Female climacteric syndrome diagnostic criteria and women are more
Term syndrome curative effect determinate standard.This group of pathological conditions integral mean is 18.1 points.It is ground with Hubei Shengfeng Drug Co., Ltd.
System selenium worm grass soybean isoflavones capsules (include selenium worm grass 0.3g, isoflavones 50mg, procyanidine 50mg) it is oral, often
Day 1 time, 2 tablets each time, symptom even served 3 months after disappearing.
Therapeutic effect：It fully recovers 47 (accounting for 48.0%)；Effective 28 (accounting for 28.6%)；Effective 22 (accounting for 22.4%)；Nothing
It imitates 1 (accounting for 1.02%).Menopause symptom integral mean is down to 4.2 points by 18.1 points, and it is court to divide symptom statistics treated effect
Heat is perspired 83%, irritable 71%, insomnia 72%, vaginal dryness 92%, weak 69%, palpitaition 61%.
Model case：
Mr. Yu female's menopause in 53 years old 2 years, April 17 2009 first visit time.Start flush, Tidal fever with perspiration occur the year before,
Symptom gradually aggravates, and number increases, and night is more so；It sleeps shallow, often has a sleepless night；Irritated, irritability；Limb muscle ache often goes out
Now knot phenomenon；Weak, tired, attention cannot be concentrated, and memory obviously declines；, there are pain in vaginal dryness, when sexual intercourse；Nearly one
Repeatedly there are the symptoms such as urgent urination, frequent micturition in year；Occur palpitaition, self-induction tachycardia once in a while.Menopause symptom integral is 18 points.Physical examination
Blood pressure 118/76mmhg, 74 beats/min of pulse；Gynecologial examination Non Apparent Abnormality.Laboratory examination：Leukorrhea routine leucocyte+；Vagina
Smear shows vagina epithelium atrophy, and based on middle layer cells, bottom cell accounts for 35%, prompts estrogen moderate low.Use selenium
1 times/day of cordyceps sinensis soybean isoflavones capsules, are taken symptom after a week and are obviously improved, above-mentioned symptom is basic after taking January by 2 tablets/time
It disappears, menopause symptom integral is 3 points.Continue to be discontinued after taking 3 months, take at quarterly intervals three months later.It has taken
6 years, do not occur menopause symptom always, annual women's physical examination breast, endometrium, attachment etc. are no abnormal.
Mr. Wang female's menopause in 50 years old 6 months, January 9 2011 first visit time.There is night flush, hectic fever before half a year
Perspire, symptom gradually aggravates, and number increases, when hectic fever winter need de- cotton dress；Insomnia, irritated, irritability；Muscular soreness of whole body,
Often there is cramp phenomenon in lower limb；Weak, tired, attention cannot be concentrated, failure of memory；Occur palpitaition, the self-induction heart once in a while
It is dynamic to overrun；Weight obviously increases in this year.Menopause symptom integral is 16 points.Physical examination blood pressure 120/82mmhg, pulse 76 times/
Point；Gynecologial examination Non Apparent Abnormality.Laboratory examination：Leukorrhea is routinely without exception；Vaginal smear shows based on middle layer cells, bottom
Confluent monolayer cells account for 30%, prompt estrogen moderate low.Using 1 times/day of selenium worm grass soybean isoflavones capsules, 2 tablets/time, one is taken
Flush, Tidal fever with perspiration symptom mitigate after week, and above-mentioned symptom disappears substantially after taking January, and menopause symptom integral is 2 points.Continue
It is discontinued after taking 3 months, takes at quarterly intervals 3 months later, dose is 1 times/day, 1 tablet/time.4 years are used, so far
Ordinary circumstance is good, and no apparent climacteric reaction mitigates when weight is compared with first visit.Annual women's physical examination breast, endometrium, attachment etc.
It is no abnormal.
So-and-so female of Wei examines on May 2012 time 20 43 the beginning of the year.Occur irregular menses from after 40 years old, when and shift to an earlier date, when
And postpone, menstrual period extend to one week or more once in a while；Sleep is poor；；Weak, tired, attention cannot be concentrated；Skin of face is dried,
Complexion is turned to be yellow, and low in glossiness, pigmented spots are apparent, and skin elasticity is poor.Use the selenium worm grass compound of prevention climacteric metancholia of women
Preparation, application method are 1 times/day, 1 tablet each time, after clean period next day start to take, take 22 days and be discontinued, next menstruation is dry
Continue to take after net.Patient take it is weak, tired after January have substantially reduced, sleep improves；Skin of face moisture increases, gloss
Improve；Pigmented spots color obviously declines after taking March, and skin elasticity obviously restores.So far it has been used continuously 3 years, menstruation week
Phase basic law is menstrual period, normal through measuring.
Using our company's independent intellectual production in a kind of selenium worm grass compound preparation of prevention climacteric metancholia of women of the present invention
The selenium worm grass for weighing production, can either effectively supplement Organic Selenium to patient, moreover it is possible to the effect of making patient obtain high-end invigorant cordyceps sinensis
Ingredient fundamentally adjusts function of human body, fights radical damage.Selenium source in the present invention is in Cordyceps militaris cultivation through life
Object converts the Organic Selenium being enriched in fructification.
Present invention application isoflavones is the characteristic for having similar structure to estrogen using it, by supplementing outside women
Source property phytoestrogen, solve ovarian failure caused by Hormone Withdrawal move back relevant disease for example menopausal syndrome, blood fat increase,
The problems such as atherosclerosis and osteoporosis.
Present invention application procyanidine has anti-aging, uvioresistant, radioresistance, brightens, moisturizing and other effects.Procyanidine
, can be in scavenger-cell film except water-soluble and fat-soluble free radical except anti-oxidation function, it is also prevention to improve blood circulation
Menopausal syndrome, the mechanism of action of anti-aging.
Specific implementation mode
Embodiment 1：A kind of selenium worm grass compound preparation of prevention climacteric metancholia of women, prevents climacteric metancholia of women
Selenium worm grass compound preparation by selenium worm grass Ultramicro-powder 0.3g, isoflavones 50mg, procyanidine 50mg and isomaltoketose
0.1g is formed, and prevents every 0.5g of selenium worm grass compound preparation of climacteric metancholia of women.
Embodiment 2：A kind of selenium worm grass compound preparation of prevention climacteric metancholia of women, prevents climacteric metancholia of women
Selenium worm grass compound preparation by selenium worm grass Ultramicro-powder 0.3g, isoflavones 50mg, procyanidine 50mg and isomaltoketose
0.1g is formed, and prevents every 0.5g of selenium worm grass compound preparation of climacteric metancholia of women.Prevent climacteric metancholia of women
Every 30 microgram containing selenium in selenium worm grass compound preparation.
Embodiment 3：A kind of selenium worm grass compound preparation of prevention climacteric metancholia of women, prevents climacteric metancholia of women
Selenium worm grass compound preparation by selenium worm grass Ultramicro-powder 0.3g, isoflavones 50mg, procyanidine 50mg and isomaltoketose
0.1g is formed, and prevents every 0.5g of selenium worm grass compound preparation of climacteric metancholia of women.Prevent climacteric metancholia of women
Selenium worm grass compound preparation processing method is by the Ultramicro-powder of 300 mesh of selenium worm grass and isoflavones, procyanidine and different malt ketone
Sugar is uniformly mixed, then is granulated, and raw material drying is tabletted to amount containing water≤6%.
Embodiment 4：A kind of selenium worm grass compound preparation of prevention climacteric metancholia of women, selenium worm grass (Hubei Province's innovation production
Product, Se content 100mg/kg) 30kg, isoflavones 5kg, grape seed extract 5kg, auxiliary material 10kg.Above-mentioned raw materials and suitable
Auxiliary material tablet is made by techniques such as crushing, granulation, drying, tablettings.Every weight 0.5g.Every Ultramicro-powder containing selenium worm grass
0.3g, 30 microgram of Se content, isoflavones 50mg, procyanidine 50mg, other auxiliary material 0.1g.
Embodiment 5：A kind of selenium worm grass soybean isoflavones capsules agent：Selenium worm grass (Hubei Province's innovative product, Se content 100mg/
Kg) 30kg, isoflavones 5kg, grape seed extract 5kg, above-mentioned material after mixing, according to preparation process by powder
(or granulation particle), which is filled in Capsules, to be made.Every 0.3g of Ultramicro-powder containing selenium worm grass, 30 microgram of Se content, the different Huang of soybean
Ketone 50mg, procyanidine 50mg.
Claims (3)
1. a kind of selenium worm grass compound preparation of prevention climacteric metancholia of women, it is characterised in that prevention climacteric metancholia of women
Selenium worm grass compound preparation include selenium worm grass Ultramicro-powder, isoflavones and procyanidine, the prevention Woman climacteric is comprehensive
Also contain isomaltoketose, the selenium worm grass compound of the prevention climacteric metancholia of women in the selenium worm grass compound preparation of simulator sickness
Preparation is made of selenium worm grass Ultramicro-powder 0.3g, isoflavones 50mg, procyanidine 50mg and isomaltoketose 0.1g, described
Prevent every 0.5g of selenium worm grass compound preparation of climacteric metancholia of women.
2. the selenium worm grass compound preparation of prevention climacteric metancholia of women described in accordance with the claim 1, it is characterised in that described
Prevention climacteric metancholia of women selenium worm grass compound preparation in every 30 microgram containing selenium.
3. preventing the selenium worm grass compound preparation of climacteric metancholia of women according to claim 2, it is characterised in that described
Prevention climacteric metancholia of women selenium worm grass compound preparation processing method be by the Ultramicro-powder of 300 mesh of selenium worm grass and soybean it is different
Flavones, procyanidine and isomaltoketose are uniformly mixed, then are granulated, and raw material drying is tabletted i.e. to amount containing water≤6%
It can.
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| CN108450962A (en) * | 2018-02-27 | 2018-08-28 | 湖北圣峰药业有限公司 | A kind of solid beverage and preparation method thereof for Woman health |
| CN109090414A (en) * | 2018-07-25 | 2018-12-28 | 天津科技大学 | A kind of blackcurrant anthocyanin alleviates the solid beverage and its preparation method and application of perimenopausal syndrome |
| KR20200136721A (en) * | 2019-05-28 | 2020-12-08 | 동아제약 주식회사 | Composition for preventing or treating woman menopause symptoms comprising Cordyceps militaris Concentrate as an active ingredient |
Citations (3)
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| CN1515251A (en) * | 2003-08-25 | 2004-07-28 | 莉 马 | Composition with function of beautifying face and its application |
| CN1562253A (en) * | 2004-04-22 | 2005-01-12 | 株洲千金药业股份有限公司 | Health foods in use for improving symptom in climacteric period of female and fabricating method |
| CN103054043A (en) * | 2013-01-29 | 2013-04-24 | 汤臣倍健股份有限公司 | Composite capsule for delaying senescence |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1515251A (en) * | 2003-08-25 | 2004-07-28 | 莉 马 | Composition with function of beautifying face and its application |
| CN1562253A (en) * | 2004-04-22 | 2005-01-12 | 株洲千金药业股份有限公司 | Health foods in use for improving symptom in climacteric period of female and fabricating method |
| CN103054043A (en) * | 2013-01-29 | 2013-04-24 | 汤臣倍健股份有限公司 | Composite capsule for delaying senescence |
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| 富硒虫草的研究进展;孟泽彬等;《微生物学通报》;20141120;第41卷(第11期);第2341-2342页第1.1和1.2节 * |
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