CN104940241A - Selenium-containing cordyceps militaris compound preparation for preventing and treating female climacteric syndromes - Google Patents
Selenium-containing cordyceps militaris compound preparation for preventing and treating female climacteric syndromes Download PDFInfo
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Abstract
The invention relates to a selenium-containing cordyceps militaris compound preparation for preventing and treating female climacteric syndromes. The selenium-containing cordyceps militaris compound preparation for preventing and treating female climacteric syndromes comprises selenium-containing cordyceps militaris ultrafine powder, isoflavone and proanthocyanidine. The selenium-containing cordyceps militaris compound preparation for preventing and treating female climacteric syndromes has the efficacies of osteoporosis prevention, beauty treatment, skin ageing prevention, immune function adjustment and senile dementia prevention.
Description
Technical field
The present invention relates to the selenium worm grass compound preparation of control menopausal syndrome, the selenium worm grass compound preparation of the control menopausal syndrome of especially health care of women.
Background technology
Female climacteric syndrome is that women's ovarian function fails to the transition period disappeared completely gradually, due to a series of clinical symptoms that physiology and psychology change and occurs, commonly warms sweating, irritable, palpitation and insomnia or melancholy forgetful etc.According to clinical manifestation, primary disease belongs to the category of " menopausal syndrome " of Chinese medicine.Primary disease be that women is before and after menopause, kidney qi is exhaustion gradually, virtual loss is appointed in punching, asthenia of essence and blood, menses is gradually exhausted, the menstruation physiological change that the menopause that arrives occurs by breaking, but some women is due to the impact of body constitution or Nervous and Mental Factors and other factors, for the moment can not adapt to these physiological changies, make negative and positive disequilibrium, internal organs QI and blood functional disorder and the syndrome of a series of function disorders that occurs.
Modern medicine is thought, climacteric syndrome is that a series of based on function disorder of autonomic nervous system caused by decrease in estrogen, endocrine disturbance, with the syndrome of neuropsychological symptom because after women's ovarian failure.That is, the basic reason of climacteric syndrome is old and feeble and cause hypo-ovaria, controls and degeneration occurs for the organ of domination and tissue by estrogen.Aging be biology As time goes on, spontaneous necessary process.Old and feeble free-radical theory is thought, the aging of cell is the result that in endocellular metabolism, harmful substance and free radical are piled up.
Free radical is some molecules or the atomic group of human body metabolism's process, containing a unpaired electron on it, free radical can make the lipid molecular peroxidating in biomembrane (as cell membrane) and electrically charged, its structure is made to become dumb, receptor on it cannot play a role, normal vital movement is caused to get muddled, diseases induced; Worse, by after peroxidating, can there is chain reflex in lipid molecular, and a molecule, by after peroxidating, can make thousands upon thousands molecules continue oxidized, cause serious harm to human body.Along with the further investigation to free radical and disease relationship, think at present to have and plant sick relevant with free radical more 70, comprise heart disease, arteriosclerosis, arthritis, allergy, cataract, senile dementia, climacteric syndrome, coronary heart disease and cancer.Radical pair biomembrane and other tissue cause damage, and cumulative Free Radical can cause body aging, and causes a series of pathological process.
In normal metabolic processes, health can produce free radical, can be removed at any time simultaneously, do not make it assemble and be detrimental to health by body antioxidant system.When free radical produces too much or Scavenging activity decline, the dynamic equilibrium between human body just can not maintain free radical generation and remove, makes there is excessive free radical accumulation in human body.Too much free radical can trigger cell membrane lipid be oxidized, and the product MDA of lipid peroxidation, also causes intracellular nucleic Acid denaturation and dysfunction, and when these detriments accumulate, body is just to aging development.25 years old time, " eliminating oxygen-derived free radicals material " in human body is the abundantest, reduce gradually later, spend 40 years old, minimizing speed accelerates particularly living environment jumpy and social environment, the ability producing free radical scavenger in the body of most of crowd is declined gradually, cause the content of scavenger in body to reduce activity also to reduce gradually, thus the defence capability weakened free radical damage, as not in time from external supplementary elimination oxygen-derived free radicals material (or claim antioxidant), human body is just easily infested with all diseases, very fast old and feeble, dead.
Women after 35 years old, every year with 1% speed reduce bone density, after climacteric more with 5 ~ 6% speed loss sclerotin.Women's endocrine gland (particularly gonad) beginning later in 35 years old is degenerated gradually, and involutional various symptom occurs.The antioxidant and the free radical scavenger level that maintain proper level in body can life-saving and delay agings.There is Free-radical ring opening polymerization in body, the damage of free radical can be defendd to greatest extent.Glutathion peroxidase (GSH-PX) is most important antioxidase in body, and vitamin c, vitamin e, selenium, procyanidin are free radical scavengers.
Summary of the invention
The problem to be solved in the present invention is in order to Prevention and Curation female climacteric syndrome; Prevention of osteoporosis disease; Looks improving and the skin nourishing, anti aging effect; Immunity moderation function; Prevention senile dementia.
A kind of selenium worm grass compound preparation preventing and treating menopausal syndrome of the present invention, is characterized in that the selenium worm grass compound preparation preventing and treating menopausal syndrome comprises selenium worm grass superfine powder, soybean isoflavone and procyanidin.
The invention discloses a kind of selenium worm grass compound preparation preventing and treating menopausal syndrome, it is characterized in that in the selenium worm grass compound preparation of described control menopausal syndrome also containing isomaltulose.
The invention discloses a kind of selenium worm grass compound preparation preventing and treating menopausal syndrome, it is characterized in that the selenium worm grass compound preparation of described control menopausal syndrome is made up of selenium worm grass superfine powder 0.3g, soybean isoflavone 50mg, procyanidin 50mg and isomaltulose 0.1g, the every sheet 0.5g of selenium worm grass compound preparation of described control menopausal syndrome.
The invention discloses a kind of selenium worm grass compound preparation preventing and treating menopausal syndrome, it is characterized in that in the selenium worm grass compound preparation of described control menopausal syndrome, every sheet is containing selenium 30 microgram.
The invention discloses a kind of selenium worm grass compound preparation preventing and treating menopausal syndrome, it is characterized in that the selenium worm grass compound preparation processing method of described control menopausal syndrome is for mix homogeneously selenium worm grass 300 object superfine powder with soybean isoflavone, procyanidin and isomaltulose, pelletize again, is pressed into tablet by raw material drying to containing water amount≤6%.
The present invention is a kind of prevent and treat the selenium worm grass compound preparation of menopausal syndrome can Prevention and Curation female climacteric syndrome; Prevention of osteoporosis disease; Looks improving and the skin nourishing, anti aging effect; Immunity moderation function; Prevention senile dementia.
A kind of selenium worm grass compound preparation suitable population preventing and treating menopausal syndrome of the present invention: more than 35 years old women.According to the understanding to women's ovarian failure, the women of one's mid-30s just starts to need to take this product.Within 40 years old, took low dose in the past, 41-50 year should use sufficient dosage, within 50 years old, needs large dose oral administration later; There is menopause syndrome person's dosage to strengthen, adjust dosage size according to personal feeling and somatic reaction.
A kind of selenium worm grass compound preparation instructions of taking preventing and treating menopausal syndrome of the present invention: the right side of fifty takes 1 without menopause syndrome daily health caring every day, takes 2 every day in more than 50 years old without menopause syndrome daily health caring, takes 3-4 month every year; There is menopause syndrome 2-3 every day sheet, after transference cure, take 3 months, take 3-4 month afterwards every year.Taboo: anemia of pregnant woman and women breast-feeding their children avoid use.
A kind of selenium worm grass compound preparation use raw material preventing and treating menopausal syndrome of the present invention is:
Selenium worm grass: Cordyceps and Radix Ginseng, Cornu Cervi Pantotrichum are equally celebrated for their achievements, are described as Chinese medicine three essentials-essence, as medicine and the existing centuries history of health product application, and are extensively familiar with by people and accept.Selenium worm grass, except containing except the intrinsic functional component such as cordycepin, cordycepic acid, Cordyceps polysaccharide of general Cordyceps, is also rich in important biological element-selenium.
Natural cs has reported kind more than 300, distribution in China the widest be Cordyceps and Cordyceps militaris.Cordyceps is known for people, and Cordyceps militaris is the abbreviation of Cordyceps militaris (L.) Link., is also Cordyceps militaris (L.) Link. or Cordyceps militaris (L.) Link., popular name Herba Cynomorii.The medicinal fungi of worm, bacterium combination, modern Valuable Herbal Medicine.Cordyceps militaris (L.) Link. belongs to Eumycota, Ascomycetes, Hypocreales, Clavicipitaceae, Cordyceps.Its primary growth is at the northern area of China.Cordyceps militaris is not only containing rich in protein and aminoacid, and the trace element containing more than 30 kind of needed by human body, is first-class excellent tonic product.To Cordyceps, there is similar function.Because wild Chinese caterpillar fungus is by a large amount of digging, its resource is several exhausted to the greatest extent, and price is extremely expensive.Therefore people have carried out the trial that artificial aweto is cultivated widely, and current tank fermentation method produces Cordyceps mycelium, artificial culture's Cordyceps militaris fruiting body succeeds, and Cordyceps militaris is approved as new resource food by Ministry of Public Health.Selenium worm grass, select by holy peak Pharmaceutical the Coragyceps militaris bacterium that poly-selenium ability is strong especially, utilize the selenium source of natural selenium resource as culture medium of bestowing favour, adopt modern biotechnology tissue culture technology, through repeatedly taming and biotransformation, make inorganic selenium by the decomposition of Cordyceps, absorb, change into the organic selenium Cordyceps sporophore be easily immediately used by the body, the active ingredient of Cordyceps is combined with effect of organic selenium, thus plays better biological action.
International and domestic many research units analyze natural cordyceps and Cordyceps militaris (artificial culture) functional component, trace element and amino acid content, and holy peak Pharmaceutical entrusts Guangzhou Institute of Analysis, sanitary inspection center, Zhongshan city, South-West Hubei agricultural byproducts Supervision Test Center, bureau of geology and mineral resources of Hubei Province bestow favour, and the units such as laboratory have carried out correlation analysis to selenium worm grass.Result shows, Cordyceps militaris, the selenium worm grass of artificial culture compare with natural cordyceps, three is basically identical in organic and inorganic nutrients composition kind, but on main functional component content the Cordyceps militaris of artificial culture, selenium worm grass higher than natural cordyceps several times to tens times (table 1, table 2, tables 3).Functional component cordycepin as distinctive in Cordyceps exceeds 35--59 doubly, and adenosine exceeds 4--5 doubly.Se content in selenium worm grass especially Radix Achyranthis Bidentatae in Cordyceps and Cordyceps militaris.And selenium mainly exists with organic selenium form in Cordyceps, through 6 batch sample measurement result statistics, organic selenium content on average accounts for 94.80% (91.67%---97.82%) of total selenium.Selenium more than 50% in Cordyceps and protein bound, be secondly combined with polysaccharide (relaxation 2009).For evaluating selenium worm grass safety, also carried out toxicological experiment, Disease Prevention Control Center, Hubei Prov shows with chmice acute Oral toxicity experimental result: the experiment of selenium worm grass fruit body powder acute oral toxicity belongs to nontoxic level.
The functional component (%) of the different Cordyceps of table 1
| Sample ID | Adenosine | Cordycepin | Cordycepic acid | Polysaccharide | Aminoacid | Protein |
| Natural cs # | 0.05 | 0.01 | 11.28 | 3.95 | 21.49 | 30.19 |
| Artificial cordyceps # | 0.21 | 0.35 | 12.00 | 4.48 | 19.10 | 43.72 |
| Selenium worm grass * | 0.26 | 0.59 | 6.70 | 2.50 | 18.27 | 25.30 |
Note: # is China Academy Of Traditional Chinese Medicine Traditional Chinese Medicine Research Institute's testing result
* for spectrum Buddhist nun tests science and technology (Beijing) testing result
The micronutrient levels 9 (ug/g) of the different Cordyceps of table 2
| Sample ID | Selenium | Zinc | Ferrum | Plumbous | Arsenic |
| Natural cs # | 0.325 | 98.99 | 959.1 | 0.217 | 6.991 |
| Artificial cordyceps # | 0.302 | 88.55 | 82.02 | 0.101 | 0.259 |
| Selenium worm grass * | 30－－－50 | 92.5 | 85.00 | 0.010 | ≥0.005 |
Note: # is Chinese Academy of Sciences's Beijing physical and chemical testing Spot detection result
* for spectrum Buddhist nun tests science and technology (Beijing) testing result
The amino acid content (g/100g) of the different Cordyceps of table 3
Note: # is Beijing City Nutrient Source Inst testing result
* for spectrum Buddhist nun tests science and technology (Beijing) testing result
Selenium is the necessary trace element of humans and animals life, the symbol of element is Se, within 1817, found by Berzhus, selenium is the 70th in chemical element in the abundance that occurring in nature exists, selenium is compared with its congeners sulfur, content much less in the earth's crust, its content is only 5/1000000ths of earth crustal mass.And distributed pole heterogeneity, in the world existing high selenium zone, also exist again and lack selenium environment on a large scale.Bestow favour be that the whole world finds the earliest, be also high selenium zone maximum up to now.Bestow favour in rich selenium resource, selenium derives from bone coal, and bone coal enters soil and water through burning and differentiation, after root system of plant and blade absorb, inorganic selenium is converted into organic selenium.The data that WHO announces shows, there is more than 40 country in the whole world, China has the county of 72% (city) to belong to low selenium and scarce selenium area, Heilungkiang, the Inner Mongol, Gansu, Qinghai, Sichuan etc. seriously lack selenium area has Keshan disease, Kaschin-Beck disease to occur, certain cancers district occurred frequently (as Jiangsu Qidong City) Ye Shudixi district.
1973, WHO and international nutritive issue confirmed that selenium is behaved and trace element necessary in animal body.The nutrition of selenium is mainly particularly combined with pheron by protein and plays antioxidation.Selenium and other trace element, vitamin have synergism, as selenium and collaborative purged body intracellular metabolite refuse---the free radical such as zinc, copper and vitamin E, vitamin C, vitamin A, carotene.Selenium has antagonism to some metal toxic element (as cadmium, hydrargyrum, arsenic, thallium etc.); Selenium can prevent fusarium toxin (T-2) to the infringement of myocardial cell, hepatocyte and chondrocyte; Selenium can antiviral, to strong carcinogen---and the non-program synthesis of leukocyte DNA that AFB1 (AFB1) is induced has blocking effect, and hepatitis B can be stoped to develop into hepatocarcinoma; Selenium has the effect regulating and improve immune function of human body, makes human body specific immunity and nonspecific immunity, humoral immunization and cellular immune function be in relative balance state; Selenium has anti-aging effects, can make laboratory animal life-saving, and has resisting fatigue effect; Selenium has radiation resistance, effectively can alleviate the toxic and side effects of cancer Radiotherapy chemotherapy, increases the dosage of anticarcinogen, is conducive to the treatment of cancer; Selenium energy vision protection, prevention occurs, and can suppress the peroxide injury of eye lens.Selenium also has one seat in hereditary field, and research in recent years shows, selenium participates in the synthesis of body internal protein, enzyme and coenzyme, and selenium---cysteine (Se-cys) is the 21st aminoacid of genetic code normal encoding.
Selenium is applied to clinical treatment and mainly contains 5 effects, i.e. deactivation in antimutagenic effect, antioxidation, the carcinogenic body of promotion, cell proliferation effect, the effect of enhancing human body immunity power.Selenium and more than 40 kind of common disease have directly and indirect relation.Selenium supplement effectively can prevent and treat Keshan disease, effective prevention Kaschin-Beck disease, selenium supplement can make hepatocarcinoma incidence rate decline 35%, has made hepatocarcinoma family history person sickness rate decline 50%, propagation in crowd of selenium supplement hepatitis B virus carriers generation capable of blocking hepatocarcinoma and hepatitis B virus and improve immune function of human body.Scarce selenium is the pathogenetic major reason of coronary disease, and WHO and International Atomic energy association are classified as selenium as one of five kinds of elements relevant with coronary heart disease and are studied.Selenium is an ideal co-adjuvant in chemotherapy of tumors, obviously can alleviate the gastrointestinal reaction, haematics toxicity, nephrotoxicity, cardiac damage etc. of cancer therapy drug, thus can improve the dose intensity of chemotherapy.In clinical treatment and prevention, organic selenium is higher than the bioavailability of inorganic selenium, and the time of staying is long in vivo, be conducive to body and set up stable selenium deposit, and toxicity is little.The every complementary diets selenium 50-250ug day by day of normal person, tumour patient recommends 300-400ug.Mo Yizeng etc. observe the impact of selenium worm grass on concurrent chemoradiotherapy of malignant tumor patient immune function and life quality, confirm that selenium worm grass Combined with Radiotherapy chemotherapy can make peripheral blood CD3, CD4 raise, also can alleviate patients symptomatic.Show that selenium worm grass can improve concurrent chemoradiotherapy of malignant tumor patient immune function, improve life in patients.
Cordycepin has the effect of broad-spectrum antiseptic, and it can suppress the growth of the pathogen such as streptococcus, Actinobacillus mallei, anthrax bacillus, pig hueppe's disease bacillus and staphylococcus.In addition, cordycepin also has inhibitory action to the skin pathogenicity funguses such as Gypsum Fibrosum sample little spore tinea bacterium, ulotrichy little spore tinea bacterium, trichophyton mentagrophytes and bacillus subtilis.Sugar demonstrates cordycepin and has very strong antifungal activity.
Cordycepin also has stronger antiviral activity.Research finds, Cordyceps have anti-herpesvirus DeJulian-Ortiz and suppresses the function of encephalitis, to HIV type virus HIV-I type infect and the activity of reverse transcription also has inhibitory action.Further investigation finds, cordycepin can suppress copying of C type RNA oncorna virus, effectively can also suppress the mRNA of virus and the synthesis of polyadenylic acid, the murine leukemia virus that BALB/3T3 and the BALB/K-3T3 cell of being induced by 5-I-2'-BrdU produces can be hindered.
Soybean isoflavone: soybean isoflavone is flavone compound, being the class secondary metabolite formed in soybeans they grow, is a kind of bioactive substance.Owing to being extract from plant, have analog structure with estrogen, therefore soybean isoflavone is also known as phytoestrogen.
Many research shows the effects such as soybean isoflavone has delaying female aging, improves menopause syndrome, the rising of osteoporosis, blood fat, breast carcinoma, carcinoma of prostate, heart disease, osteoporosis, cardiovascular disease.Soybean isoflavone can replace estrogen to be combined with ER playing estrogen-like effects, estrogen can be disturbed again to be combined with ER, show as the effect of estrogen antagonist sample.Soybean isoflavone display estrogen activity or antiestrogenic depend primarily on the hormone metabolism state of study subject itself.To the horizontal person of high estrogen, as animal and the young woman of young animals and estrogen, display antiestrogenic; To estrogen level junior, as brood, removal ovary animal, menopausal women, display estrogen activity.The estrogen-like effects of the soybean isoflavone disease that many and Hormone Withdrawal dephasign closes to elderly woman as climacteric syndrome, blood fat raise, atherosclerosis and osteoporosis etc., have certain preventive and therapeutic action.The oestrogen-like hormone effect of soybean isoflavone, the sexual organ that women is important can be moistened---vagina, increases gonad secretion, thickens vagina epithelium, women vagina muscles elasticity is strengthened, thus improve life quality.
Annual about ten to ten two times of women's ovulation of 20 years old to 25 years old, within 40 years old, later women is often only ovum seven, eight times, subtracts until termination of ovulating after 5 years again.Reduce along with ovulation and stop, women estrogen level reduces gradually, and according to the understanding to women's ovarian failure, the women of one's mid-30s just starts to need to take isoflavone.Within 40 years old, took low dose in the past, 41-50 year should use sufficient dosage, within 50 years old, needs large dose oral administration later; There is menopause syndrome person's dosage to strengthen, adjust dosage size according to personal feeling and somatic reaction.
Soybean isoflavone is applied in this preparation, it is the characteristic utilizing itself and estrogen to have analog structure, by supplementary women's exogenous plant estrogen, solve the disease of Hormone Withdrawal dephasign pass caused by ovarian failure as problems such as climacteric syndrome, blood fat rising, atherosclerosis and osteoporosises.
Procyanidin: procyanidin (Proanthocyanidins, PC) also there is extremely strong antioxidation, eliminate the effect of free radical, can effectively eliminate ultra-oxygen anion free radical and hydroxyl radical free radical, also participating in phosphoric acid, arachidonic metabolism and protein phosphorylation, there is not peroxide injury in protection lipid; Strong metal-chelator, can chelated metal ions, form inert compound in vivo; Protection and stable vitamin c, contribute to absorption and the utilization of vitamin c.For skin, it can recover activity of collagen, makes skin level and smooth and flexible.Collagen protein is the fundamental component of skin, and is a kind of colloid substance making our health become as a whole.Vitamin C is the nutriment of biochemical synthesis collagen protein necessity.Procyanidin makes more vitamin C come into force, and this means, vitamin C more easily can go its all functions (comprising collagen protein to produce).Procyanidin is connected on collagen protein, and those can be stoped to destroy the harm of the enzyme of collagen protein.Procyanidin not only helps collagen fabric to form cross-linked structure, and can help to recover the excessively crosslinked infringement because of caused by injured and free radical.Excessively being cross-linked to make connective tissue suffocate and harden, thus skin is corrugated and premature aging.Therefore anthocyanidin there is defying age, uvioresistant, radioprotective, brighten, the effect such as moisturizing.
Procyanidin can alleviate premenstrual (anxiety) syndrome and the climacteric syndrome symptom of women.Because hormone disequilibrium, brain, ovary and uterus can not get enough oxygen.Psychological and health there will be perhaps various disease conditions as sore waist and aching in the waist and the back, abdominal part swell, muscle spasm, personality change (as fly into a rage, fly into a rage, even want to commit suiside), depressed, fatigue, faint, have a sleepless night, arthralgia, headache, urinary tract infection.Procyanidin can strengthen blood capillary, tremulous pulse and vein blood vessel, improves blood circulation.Therefore, its effect of having detumescenceization to become silted up.The drag reduction of blood capillary and permeability improve, and make cell more easily absorb nutrient and get rid of refuse.Therefore, procyanidin, can in scavenger cell film outside water solublity and fat-soluble free radical except anti-oxidation function, and improving blood circulation is also prevent and treat climacteric syndrome, the antidotal mechanism of action.
Isomaltulose: white crystals, odorless, taste are sweet, sugariness is about sucrose 42%, sweet taste is pure, substantially identical with sucrose, without bad aftertaste, fusing point 122 ~ 124 DEG C, specific rotatory power (α) 20D97.2 °, acidproof, heat-resisting, facile hydrolysis (20% solution, 100 DEG C of heating 60min when pH2.0 still do not decompose, and sucrose can all be hydrolyzed under similarity condition) heat stability is not lower than sucrose, soluble in water, the viscosity of its aqueous solution is also lower slightly than the sucrose of comparable sodium.This product by enzymolysis, can be absorbed by body in intestinal.Little on blood glucose value impact, unlikely dental caries.Isomaltulose is the natural saccharide of one found in the product such as Caulis Sacchari sinensis, Mel, because it has the function that can not cause decayed tooth.The whole world is researched and developed in a large number, is widely used in various food and sweeting agent.The function and application of isomaltulose is developed always successively.Such as latest find it especially have specific functionality to human body brain; It is also a kind of special sweeting agent, has unique absorption and digestion.Be applicable to very much being applied in confection, beverage and various food.Because the secretion of insulin can not be caused after the digested absorption of isomaltulose, the activation of LPL activity also would not be caused.So the existence of isomaltulose makes oils and fats be not easy to be absorbed in fatty tissue.
Selenium worm grass 300 object superfine powder is first mixed homogeneously with soybean isoflavone, procyanidin and isomaltulose when a kind of selenium worm grass compound preparation preventing and treating menopausal syndrome uses by the present invention, pelletize again, is pressed into tablet by raw material drying to containing water amount≤6%.
A kind of selenium worm grass compound preparation preventing and treating menopausal syndrome of the present invention, Cordyceps is formed under special ecology and extreme environment, and it has special gene and expression product and character, is the precious genetic resource of the mankind.The selenium worm grass that Hubei Shengfeng Drug Co., Ltd. utilizes local abundant natural selenium resource to cultivate through studying for many years, is combined into one effect of Cordyceps and the effect of selenium.The Cordyceps gene of high-quality is allowed to obtain perfect expressions in the product.Therefore can think: selenium worm grass comes from Cordyceps, merit, in Cordyceps, is the health partner of successful personage, is again disease and subhealth state colony best nutritional tonic.
A kind of use preventing and treating the selenium worm grass compound preparation of menopausal syndrome of the present invention:
The climacteric syndrome patient data 2010 being taken voluntarily to selenium worm grass soybean isoflavones capsules during in December, 2014 adds up, and inquires into the clinical efficacy by selenium worm grass soybean isoflavones capsules treatment climacteric syndrome.
Complete data person is totally 98 examples, and the age is 44-55 years old (average 49.2 years old), the course of disease 3 months to 3 years (average 14.2 months).Diagnosis and curative effect are with reference to " new Chinese medicine guideline of clinical investigations " female climacteric syndrome diagnostic criteria and female climacteric syndrome curative effect determinate standard.This group pathological conditions integral mean is 18.1 points.Oral with the selenium worm grass soybean isoflavones capsules (include selenium worm grass 0.3g, soybean isoflavone 50mg, procyanidin 50mg) of Hubei Shengfeng Drug Co., Ltd.'s development, every day 1 time, each 2, after transference cure, serve on 3 months.
Therapeutic effect: 47 examples of fully recovering (accounting for 48.0%); Effective 28 examples (accounting for 28.6%); Effective 22 examples (accounting for 22.4%); Invalid 1 example (accounting for 1.02%).Menopause syndrome integral mean is down to 4.2 points by 18.1 points, a point symptom statistics treated effect be perspire 83% towards heat, irritable 71%, have a sleepless night 72%, vaginal dryness 92%, weak 69%, cardiopalmus 61%.
Model case:
In certain female menopause in 53 years old 2 years, April 17 2009 first visit time.Start the year before to occur flushing, Tidal fever with perspiration, symptom increases the weight of gradually, increased frequency, and night more so; Sleep shallow, often have a sleepless night; Irritated, irritability; , often there is cramp phenomenon in limb muscle ache; Weak, tired, attention can not be concentrated, and memory obviously goes down; Vaginal dryness, has pain during sexual intercourse; Closely several times a year there is the symptom such as urgent micturition, frequent micturition; There is cardiopalmus once in a while, self-induction tachycardia.Menopause syndrome integration is 18 points.Health check-up blood pressure 118/76mmhg, 74 beats/min, pulse; Gynecologial examination Non Apparent Abnormality.Lab testing: the conventional leukocyte of leucorrhea+; The atrophy of vaginal smear display vagina epithelium, based on middle layer cells, bottom cell accounts for 35%, and prompting estrogen moderate is low.Use selenium worm grass soybean isoflavones capsules 1 times/day, 2 tablets/time, take symptom after a week and obviously improve, after taking January, above-mentioned symptom disappears substantially, and menopause syndrome integration is 3 points.Continue to take drug withdrawal after 3 months, take three months at quarterly intervals afterwards.Taken 6 years, do not occurred menopause syndrome always, annual women's health check-up breast, endometrium, adnexa etc. are no abnormal.
So-and-so female of king menopause in 50 years old 6 months, January 9 2011 first visit time.Namely occurred flushing at night, Tidal fever with perspiration before half a year, symptom increases the weight of gradually, increased frequency, and during hectic fever, winter needs de-cotton dress; Insomnia, irritated, irritability; Muscular soreness of whole body, often there is cramp phenomenon in lower limb; Weak, tired, attention can not be concentrated, hypomnesis; There is cardiopalmus once in a while, self-induction tachycardia; Body weight obviously increases in this year.Menopause syndrome integration is 16 points.Health check-up blood pressure 120/82mmhg, 76 beats/min, pulse; Gynecologial examination Non Apparent Abnormality.Lab testing: leucorrhea routine is without exception; Vaginal smear display is based on middle layer cells, and bottom cell accounts for 30%, and prompting estrogen moderate is low.Use selenium worm grass soybean isoflavones capsules 1 times/day, 2 tablets/time, take flushing, Tidal fever with perspiration symptom after one week and alleviate, after taking January, above-mentioned symptom disappears substantially, and menopause syndrome integration is 2 points.Continue to take drug withdrawal after 3 months, take 3 months at quarterly intervals afterwards, dose is 1 times/day, 1 tablet/time.Used 4 years, ordinary circumstance is good so far, reacts without obvious climacteric, body weight comparatively first visit time alleviate.Annual women's health check-up breast, endometrium, adnexa etc. are no abnormal.
Wei, so-and-so female 43 examined May 20 2012 time the beginning of the year.After 40 years old, there is irregular menses, time and shift to an earlier date, time and postpone, extend to more than one week menstrual period once in a while; Sleep poor; ; Weak, tired, attention can not be concentrated; Skin of face is dry, and complexion is turned to be yellow, low in glossiness, and pigmented spots are obvious, and skin elasticity is poor.Use the selenium worm grass compound preparation of control menopausal syndrome, using method is 1 times/day, each 1, and after clean period, next day starts to take, and takes drug withdrawal in 22 days, continues to take after next clean period.Patient is weak after taking January, fatigue has and obviously alleviates, and sleep takes a turn for the better; Skin of face moisture increases, improving gloss; After taking March, pigmented spots color obviously goes down, and skin elasticity is obviously recovered.So far 3 years are used continuously, menstrual cycle basic law, menstrual period, normal through measuring.
The present invention is a kind of prevents and treats in the selenium worm grass compound preparation of menopausal syndrome the selenium worm grass applied our company's independent intellectual property right and produce, effectively organic selenium can either be supplemented to patient, patient can also be made to obtain the functional component of high-end tonic Cordyceps, fundamentally regulate function of human body, antagonism radical damage.Selenium source in the present invention transforms the Organic Selenium in sporophore enrichment through biology in Cordyceps militaris (L.) Link. cultivation.
The present invention's application soybean isoflavone, it is the characteristic utilizing itself and estrogen to have analog structure, by supplementary women's exogenous plant estrogen, solve the disease of Hormone Withdrawal dephasign pass caused by ovarian failure as problems such as climacteric syndrome, blood fat rising, atherosclerosis and osteoporosises.
The effects such as the present invention's application procyanidin has defying age, uvioresistant, radioprotective, brightens, moisturizing.Procyanidin, can in scavenger cell film outside water solublity and fat-soluble free radical except anti-oxidation function, and improving blood circulation is also prevent and treat climacteric syndrome, the antidotal mechanism of action.
Detailed description of the invention
Embodiment 1: a kind of selenium worm grass compound preparation preventing and treating menopausal syndrome, the selenium worm grass compound preparation of control menopausal syndrome is made up of selenium worm grass superfine powder 0.3g, soybean isoflavone 50mg, procyanidin 50mg and isomaltulose 0.1g, the every sheet 0.5g of selenium worm grass compound preparation of control menopausal syndrome.
Embodiment 2: a kind of selenium worm grass compound preparation preventing and treating menopausal syndrome, the selenium worm grass compound preparation of control menopausal syndrome is made up of selenium worm grass superfine powder 0.3g, soybean isoflavone 50mg, procyanidin 50mg and isomaltulose 0.1g, the every sheet 0.5g of selenium worm grass compound preparation of control menopausal syndrome.In the selenium worm grass compound preparation of control menopausal syndrome, every sheet is containing selenium 30 microgram.
Embodiment 3: a kind of selenium worm grass compound preparation preventing and treating menopausal syndrome, the selenium worm grass compound preparation of control menopausal syndrome is made up of selenium worm grass superfine powder 0.3g, soybean isoflavone 50mg, procyanidin 50mg and isomaltulose 0.1g, the every sheet 0.5g of selenium worm grass compound preparation of control menopausal syndrome.The selenium worm grass compound preparation processing method of control menopausal syndrome is mixed homogeneously with soybean isoflavone, procyanidin and isomaltulose by selenium worm grass 300 object superfine powder, then pelletize, and raw material drying is pressed into tablet to containing water amount≤6%.
Embodiment 4: a kind of selenium worm grass compound preparation preventing and treating menopausal syndrome, selenium worm grass (Hubei Province's innovative product, Se content 100mg/kg) 30kg, soybean isoflavone 5kg, Semen Vitis viniferae extract 5kg, adjuvant 10kg.Above-mentioned raw materials and suitable adjuvant make tablet by techniques such as pulverizing, pelletize, drying, tablettings.The heavy 0.5g of every sheet.Every sheet contains selenium worm grass superfine powder 0.3g, Se content 30 microgram, soybean isoflavone 50mg, procyanidin 50mg, other adjuvant 0.1g.
Embodiment 5: a kind of selenium worm grass soybean isoflavones capsules agent: selenium worm grass (Hubei Province's innovative product, Se content 100mg/kg) 30kg, soybean isoflavone 5kg, Semen Vitis viniferae extract 5kg, after above-mentioned mixing of materials is even, according to preparation process, powder (or granulation granule) is filled in Capsules and makes.Every contains selenium worm grass superfine powder 0.3g, Se content 30 microgram, soybean isoflavone 50mg, procyanidin 50mg.
Claims (5)
1. prevent and treat a selenium worm grass compound preparation for menopausal syndrome, it is characterized in that the selenium worm grass compound preparation preventing and treating menopausal syndrome comprises selenium worm grass superfine powder, soybean isoflavone and procyanidin.
2., according to the selenium worm grass compound preparation of control menopausal syndrome according to claim 1, it is characterized in that in the selenium worm grass compound preparation of described control menopausal syndrome also containing isomaltulose.
3. according to the selenium worm grass compound preparation of control menopausal syndrome according to claim 2, it is characterized in that the selenium worm grass compound preparation of described control menopausal syndrome is made up of selenium worm grass superfine powder 0.3g, soybean isoflavone 50mg, procyanidin 50mg and isomaltulose 0.1g, the every sheet 0.5g of selenium worm grass compound preparation of described control menopausal syndrome.
4., according to the selenium worm grass compound preparation of the control menopausal syndrome described in claim 1 or 2, it is characterized in that in the selenium worm grass compound preparation of described control menopausal syndrome, every sheet is containing selenium 30 microgram.
5. according to the selenium worm grass compound preparation of control menopausal syndrome according to claim 2, it is characterized in that the selenium worm grass compound preparation processing method of described control menopausal syndrome is for mix homogeneously selenium worm grass 300 object superfine powder with soybean isoflavone, procyanidin and isomaltulose, pelletize again, is pressed into tablet by raw material drying to containing water amount≤6%.
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| CN108450962A (en) * | 2018-02-27 | 2018-08-28 | 湖北圣峰药业有限公司 | A kind of solid beverage and preparation method thereof for Woman health |
| CN109090414A (en) * | 2018-07-25 | 2018-12-28 | 天津科技大学 | A kind of blackcurrant anthocyanin alleviates the solid beverage and its preparation method and application of perimenopausal syndrome |
| WO2020241958A1 (en) * | 2019-05-28 | 2020-12-03 | 동아제약 주식회사 | Composition for preventing or treating woman menopause symptoms, comprising cordyceps militaris concentrate as active ingredient |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108450962A (en) * | 2018-02-27 | 2018-08-28 | 湖北圣峰药业有限公司 | A kind of solid beverage and preparation method thereof for Woman health |
| CN109090414A (en) * | 2018-07-25 | 2018-12-28 | 天津科技大学 | A kind of blackcurrant anthocyanin alleviates the solid beverage and its preparation method and application of perimenopausal syndrome |
| WO2020241958A1 (en) * | 2019-05-28 | 2020-12-03 | 동아제약 주식회사 | Composition for preventing or treating woman menopause symptoms, comprising cordyceps militaris concentrate as active ingredient |
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| CN104940241B (en) | 2018-09-21 |
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