CN1562253A - Health foods in use for improving symptom in climacteric period of female and fabricating method - Google Patents
Health foods in use for improving symptom in climacteric period of female and fabricating method Download PDFInfo
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- CN1562253A CN1562253A CN 200410023131 CN200410023131A CN1562253A CN 1562253 A CN1562253 A CN 1562253A CN 200410023131 CN200410023131 CN 200410023131 CN 200410023131 A CN200410023131 A CN 200410023131A CN 1562253 A CN1562253 A CN 1562253A
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- health food
- radix
- soybean isoflavone
- fructus lycii
- food
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Landscapes
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Abstract
A health-care food for relaxing the femal climacteric syndrome is prepared from 6 raw materials including soybean isoflavone, proanthocyanidin and 4 Chinese-medicinal materials including wolfberry fruit, etc.
Description
Technical field
The present invention relates to a kind of health food of improving female menopause symptoms and preparation method thereof that is used to, belong to Chinese medicine and health product manufacture method class.
Background technology
Women's " climacteric " is that the women enters the important physiological stage that 45-55 must experience during year, it is that the women is along with the genitals ovarian function is faded, the endocrine estrogen decrease, menoxenia appears up to stopping, and cause a series of physiological changies of its generation, Here it is medically alleged " climacteric syndrome ".Many uncomfortable symptoms appear in most of women's federations in this period, as symptom such as: hectic fever, perspiration, nervous, tired, absent minded, depressed, nervous, emotional lability, short-tempered, insomnia, suspicious, forgetful, limbs sensory disturbance, dizziness and tinnitus, bone joint pain even genitals with mammary gland atrophy, skin follow the string, vagina burn feeling and skin pruritus, hyposexuality and sexual life difficulty, and merge diseases such as urinary system infection takes place easily.
Along with the Chinese society expanding economy, the improving constantly of material progress degree, social population's aging trend day by day manifests, and according to statistics, the women of China more than 50 years old reached 1.5 hundred million at present, expects 2010 and then can reach 1.8 hundred million people.Huge middle aged and aged women crowd quantity like this, they are entering the puzzled stage of human natural physiological phenomenon, and all physiology of initiation and healthy problem must receive the concern of society; Society also will face the improvement and the treatment of Women weather more, face the consumption demand that health care market grows stronger day by day.
Can provide in the market, be applied to keep healthy and treat the product of climacteric syndrome not only quantity is few, and product assimilation degree height, what most products materials were formed simply, had owes scientific and reasonable, and the manufacturing technology level that has is low, is seriously restricting health, the fast development of health-product market.How for vast climacteric women patient provides a kind of care characteristics that has more, more help helping climacteric women safety, health, happyly tide over involutional ideal health care product, be relevant R﹠D and production producer and consumers in general's common expectation.
Technology contents
Purpose of the present invention: aim to provide a kind of health food that is used to improve female menopause symptoms, and the manufacture method of health food.
This health food that is used to improve female menopause symptoms is characterized in that: it is to be made by the following weight proportion raw material: Fructus Schisandrae Chinensis 20～50, Radix Et Caulis Acanthopanacis Senticosi 10～40, Fructus Lycii 5～35, Radix Ophiopogonis 5～35, soybean isoflavone 0.6～2.8, procyanidin 0.4～1.6.
Its manufacture method is: A, at first with extraction behind alcohol-pickled 2 hours of 70% concentration once with the Fructus Schisandrae Chinensis that takes by weighing, Radix Et Caulis Acanthopanacis Senticosi two flavor medical materials, and filtered and recycled ethanol obtains standby Fructus Schisandrae Chinensis, Radix Et Caulis Acanthopanacis Senticosi mixed extract; B, Fructus Lycii, twice of water boiling and extraction of flavor medical material Radix Ophiopogonis two with taking by weighing, 1.5 hours for the first time, 1 hour for the second time, and filtered while hot, merging twice filtrate and obtain Fructus Lycii, Radix Ophiopogonis mixed liquor, it is 1.2/80 ℃ that this mixed liquor is concentrated into proportion, the cooling back adds the ethanol sedimentation of 95% concentration, make it to reach and left standstill under 60% state 24 hours, get the supernatant recovered alcohol and get Fructus Lycii, Radix Ophiopogonis extract in the alcohol amount of containing, standby; The extracting solution that makes in C, merging A, B two steps, further simmer down to proportion is the extractum of 1.2-1.3, drying and crushing; D, with the medicated powder of C step gained, add soybean isoflavone that is taken from Semen sojae atricolor and the procyanidin that is taken from Semen Vitis viniferae, and starch supplementary material, behind abundant stirring and evenly mixing,, make capsule, make tablet through tablet forming technique through filling process with ethanol granulation, drying.
The content of the soybean isoflavone that is adopted is 40%; The content of the procyanidin that is adopted is 95%.
Described this health food is a kind of capsule-shaped food.
Described this health food is a kind of tablet food.
This health food that is used to improve female menopause symptoms, both continued to use the theory of Chinese medicine integration of edible and medicinal herbs, residence is cured in food, again soybean isoflavone that helps health and the procyanidin that obtains in the human modern science and technology research applied in the composition of raw materials simultaneously, replenish the deficiency of climacteric women body inner estrogen, and, improved the human body regulative mechanism in conjunction with the Chinese medicine of relevant integration of edible and medicinal herbs.
The specific embodiment
Below in conjunction with embodiments of the invention, and further set forth the present invention in conjunction with the embodiments.
This health product that are used to improve female menopause symptoms, inherited the theory of China's tradition traditional Chinese medical science " integration of edible and medicinal herbs ", wherein the four Chinese medicine material was row and pushed away for the physician and to be the good merchantable brand in the medicinal herbs most in use Chinese crude drug Fructus Schisandrae Chinensis of Cai Yonging, Radix Et Caulis Acanthopanacis Senticosi, Fructus Lycii, Radix Ophiopogonis; Its medicine is analyzed as follows:
Originate in the Fructus Schisandrae Chinensis in China northeast, contain abundant multivitamin, organic acid, (especially free amino acid and in conjunction with aminoacid), its biological value and nutriture value are significantly higher than all kinds of fruits and vegetables, especially the general fruits and vegetables common far above people aspect trace element, organic acid, multivitamin nutrition; In traditional Chinese medicine, think effects such as it has the kidney invigorating, QI invigorating, promotes the production of body fluid, antidiarrheal to be usually used in vital energy benefiting and the kidney invigorating, tranquillizing and allaying excitement symptoms such as treatment neurasthenia, forgetful, insomnia, overfatigue, dizziness; More there were some scholars from Fructus Schisandrae Chinensis, to isolate two kinds in recent years and can be used for the treatment of the impaired and damaged polysaccharide of immune system of body immune system.
Contain Radix Et Caulis Acanthopanacis Senticosi A, B in its material composition of the Radix Et Caulis Acanthopanacis Senticosi that uses in this prescription, Eleutheroside B 1, eleutheroside D and E, and polysaccharide and sesamin, modern age, medicine and pharmacology studies have shown that it had some identical effects of Radix Ginseng; Pharmacological research proves that it has good antifatigue effect, and can obviously improve hypoxia-bearing capability; Energy enhancing body nonspecific immunity protection capability; Can improve proteinic biosynthesis, reduce basal metabolism, effect such as can also promote gonad and bring high blood pressure down.Weak to yang deficiency, body void in traditional traditional Chinese medical science, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep are effective in cure.
The Fructus Lycii that adopts in the prescription, it is a kind of medicine, also be a kind of food, it contains abundant nutrition and pharmaceutically-active ingredients, have " liver heat removing, lung moistening, nourishing kidney, QI invigorating spermatogenesis, supporing yang, dispel the wind, make eye bright, tonify deficiency labor and strengthing aitch bone " effect, both risen and regulated immunity, blood lipid regulation, blood sugar regulation, function in delaying senility; But also has good removing free radical effect.Therefore since ancient times, it is exactly the traditional rare medicinal herbs of China, thereby is subjected to domestic and abroad medical circle and dietetic therapy expert's great attention.Why brainstrust payes attention to this medical material, and its main cause is: Fructus Lycii contains the polysaccharide that the very abundant acid heteroglycan homopolypeptide of being made up of arabinose, rhamnose, xylose, mannose, breast enlargement sugar, glucose and breast enlargement alditol sugar or protein constitute.This many compositions polysaccharide has the physiological function that improves the human body immunity, thereby has bigger practicality than the immunoglobulin that extracts from animal blood.
The Radix Ophiopogonis of being adopted in the prescription, just on the books in Shennong's Herbal, be YIN nourishing Chinese medicine commonly used, have YIN nourishing and the production of body fluid promoting, the lung moistening function that clears away heart-fire, contain steroidal emperor glycoside, homoisoflavone, polysaccharide, aminoacid etc. in its Main Ingredients and Appearance, anti-blood flesh anoxia, antiarrhythmic effect that tool is certain.
For another kind of the adding materials of adopting among the present invention---soybean isoflavone and procyanidin, be two kinds of biological product that the contemporary science and technology personnel extracted from fruit and vegerable such as Semen sojae atricolor and Semen Vitis viniferae during the 70-90 age in last century.
Wherein soybean isoflavone is a class secondary metabolite that forms in the soybeans they grow process, and it mainly is made up of nine kinds of glycosides and three kinds of corresponding glycocides, how to exist with β-Fructus Vitis viniferae glycoside form under the natural situation; Soybean isoflavone belongs to phytohormone, and its chemical constitution is similar to estrogen.Personnel studies show that through relevant technologies, and this soybean isoflavone that is taken from Semen sojae atricolor has four kinds of functions:
One, soybean isoflavone has estrogen and anti-estrogen action; When soybean isoflavone is positioned on the human body estrogen sensor, its hormonal activity a little less than, can prevent effectively that human body estrogen from accumulating on the sensor.This result neither can end estrogenic normal reproduction and production function, but can reduce the probability that hormone brings out cancer.A lot of tumors, particularly breast carcinoma are very sensitive to estrogen.Estrogen gathers on the cell sensor, stimulate tumor growth, and soybean isoflavone can occupy the estrogen sensor, makes estrogen be difficult to assemble.Experiment shows: genistein and daidzein are very effective aspect inhibition breast carcinoma.This is the anti-estrogen action of soybean isoflavone.Soybean isoflavone also has the activity effect relevant with estrogen simultaneously, mainly is: improve and reduction Woman climacteric symptom, the cholesterol reducing level prevents that the cardiovascular diseases aspect from playing help etc.
Two, have the enzyme that suppresses cancer, the effect that reduces cancer risk; Because soybean isoflavone is a kind of effectively kinases inhibitor, can hinder the signal of the promotion cell growth that the cancerous cell sensor sends, hinder the nutrition supply of tumor and reach antitumaous effect.
Three, genistein in the soybean isoflavone and daidzein are effective anti-oxidants, and it can effectively remove the harmful free radical that produces among the human physiological activity.
Four, improve immune function of human body
The procyanidin that adopts in the constituent is the poly-Polyphenols mixture that extensively exists in the multiple fruit-vegetable plant of nature, main monomer, dimer, trimer by catechin ... ten aggressiveness are formed by combining.Oligomeric Proanthocyanidins (two-tetramer) is celebrated with its high-efficiency low-toxicity, high bioavailability, because it has strong oxidation resistance, the ability of its antioxidation, removing free radical is V in human body
E50 times, V
C20 times, be widely used in fields such as food, beverage, cosmetics and health product at present.Show that through clinical use it has good curative effect to periphery impaired function of vein, multiple ophthalmic diseases, lymphedema and some capillary hyperamization pipe diseases.
Below provide embodiments of the invention (by weight percentage), and further set forth the present invention:
Composition embodiment 1 embodiment 2 embodiment 3
Fructus Schisandrae Chinensis 20% 35% 50%
Radix Et Caulis Acanthopanacis Senticosi 40% 25% 10%
Fructus Lycii 5% 20% 35%
Radix Ophiopogonis 35% 20% 5%
40% soybean isoflavone 0.6% 1.7% 2.8%
95% procyanidin 1.6% 1.0% 0.4%
In above-mentioned three embodiment, be used for the starch supplementary material of molding, can do suitably to adjust according to technological requirement.
Method: A, at first with extraction behind alcohol-pickled 2 hours of 70% concentration once with the Fructus Schisandrae Chinensis that takes by weighing, Radix Et Caulis Acanthopanacis Senticosi two flavor medical materials, filtered and recycled ethanol obtains standby Fructus Schisandrae Chinensis, Radix Et Caulis Acanthopanacis Senticosi mixed extract; B, Fructus Lycii, twice of water boiling and extraction of flavor medical material Radix Ophiopogonis two with taking by weighing, 1.5 hours for the first time, 1 hour for the second time, and filtered while hot, merging twice filtrate and obtain Fructus Lycii, Radix Ophiopogonis mixed liquor, it is 1.2/80 ℃ that this mixed liquor is concentrated into proportion, the cooling back adds the ethanol sedimentation of 95% concentration, make it to reach and left standstill under 60% state 24 hours, get the supernatant recovered alcohol and get Fructus Lycii, Radix Ophiopogonis extract in the alcohol amount of containing, standby; The extracting solution that makes in C, merging A, B two steps, further simmer down to proportion is the extractum of 1.2-1.3, drying and crushing; D, with the medicated powder of C step gained, add soybean isoflavone that is taken from Semen sojae atricolor and the procyanidin that is taken from Semen Vitis viniferae, and starch supplementary material, behind abundant stirring and evenly mixing,, make capsule, make tablet through tablet forming technique through filling process with ethanol granulation, drying.
The inventor is according to related indication performance of climacteric and said composition function to be expressed, and selecting 52 from the women in 255 40-55 year of conscientiously filling in the menopause syndrome application form has the needs of above-mentioned binomial or above symptom to improve the women of its symptom as examination clothes person.Our employing is taken the mode of monitoring record and examination clothes person scoring and is taken effect expedition, and resulting preliminary data can reflect the symptom variation before and after taking basically, promptly is the situation of change before and after several investigation indexs are taken below:
1, took through ten days after, have 90% to have the trier of sleep disorder to feel that sleep has clear improvement, sleeping easily, and sleep quality improves a lot; After taking through 30 days, there is the trier of sleep disorder to feel that sleep has clear improvement before having 98.4% to take, generally can be very fast sleeping, and be difficult for being waken up with a start, daytime, the mental status was clearly better.
2, took through 15 days after, 88.3% the preceding paresthesia of skin of taking is arranged, xerosis cutis, tarnish, the trier describes the cutis laxa phenomenon goes down, skin is flexible; After taking through 30 days, have 92.6% to take preceding paresthesia of skin, xerosis cutis, matt trier describe skin and are further improved, and can maintain certain smooth elasticity.
3, took through 15 days after, have 79.2% often to feel hot on the face, no cause is perspired, and sees the thing dim eyesight, headache, trier's sensory symptoms of symptoms such as tinnitus improves; After taking through 30 days, hot on the face rubescent before having 89.7% to take, no cause is perspired and is seen the thing dim eyesight, headache, the tinnitus symptom feels that obviously hot heating number of times and persistent period reduce afternoon hypohidrosis even lossless, it is clear to look thing, and identification ability has obvious enhancing.
4, took through 15 days after, 44.4% take before demand have lumbar vertebra pain, cervical vertebra ache or arthralgia person (account for 12/27 take before this option need the improver) the feels pain degree reduces, the painful area radius of action increases; Took through 30 days, 77.8% take before demand have lumbar vertebra pain, cervical vertebra ache or arthralgia person (account for 21/27 take before this option need the improver) obviously the feels pain degree reduce greatly, pain time significantly reduces, once used examination clothes person (22.2%) access times and each time of cervical vertebrae traction all to significantly reduce, even do not re-use (11.1%).
5, all examination clothes all do not have discomfort during the person takes or rejection takes place, and feel good.
52 have the women of following menopause syndrome to try to obey these health product, each shape disease type before taking
| Symptom type | Selection result | ||||
| Do not have | Gently | In | Heavy | Extremely heavy | |
| Chest pain or constriction is arranged, sometimes breathless | ??11 | ??18 | ??11 | ??7 | ??5 |
| Finger or toe paroxysmal numbness | ??13 | ??14 | ??12 | ??8 | ??5 |
| Heart beating is sometimes fast and sometimes slow, and nervous (being that heartbeat is quick unusually, strong, irregular), chest tightness are often sighed | ??11 | ??15 | ??12 | ??13 | ??1 |
| Lumbago, arthralgia, muscle twitches, heel pain, cervical vertebra pain | ??9 | ??16 | ??14 | ??9 | ??4 |
| Hot on the face rubescent, no cause is perspired, and sees the thing dim eyesight, headache, tinnitus | ??6 | ??9 | ??24 | ??11 | ??2 |
| Paresthesia of skin, xerosis cutis, tarnish | ??8 | ??14 | ??17 | ??11 | ??2 |
| Difficulty falling asleep, insomnia-middle is waken up with a start easily, insomnia, dreaminess | ??3 | ??7 | ??15 | ??21 | ??6 |
| Irritated, easy on the trigger (be afraid of sad, emotional), easily envy others | ??2 | ??13 | ??13 | ??20 | ??4 |
Test shows: use constituent provided by the invention, to improving female dimacteric syndrome good effect is arranged.
Claims (5)
1, a kind of health food that is used to improve female menopause symptoms is characterized in that: it is to be made by the following weight proportion raw material: Fructus Schisandrae Chinensis 20～50, Radix Et Caulis Acanthopanacis Senticosi 10～40, Fructus Lycii 5～35, Radix Ophiopogonis 5～35, soybean isoflavone 0.6～2.8, procyanidin 0.4～1.6.
2, a kind of health food that is used to improve female menopause symptoms according to claim 1, it is characterized in that: manufacture method is: A, at first with the Fructus Schisandrae Chinensis that takes by weighing, Radix Et Caulis Acanthopanacis Senticosi two flavor medical materials with extraction behind alcohol-pickled 2 hours of 70% concentration once, filtered and recycled ethanol obtains standby Fructus Schisandrae Chinensis, Radix Et Caulis Acanthopanacis Senticosi mixed extract; B, Fructus Lycii, twice of water boiling and extraction of flavor medical material Radix Ophiopogonis two with taking by weighing, 1.5 hours for the first time, 1 hour for the second time, and filtered while hot, merging twice filtrate and obtain Fructus Lycii, Radix Ophiopogonis mixed liquor, it is 1.2/80 ℃ that this mixed liquor is concentrated into proportion, the cooling back adds the ethanol sedimentation of 95% concentration, make it to reach and left standstill under 60% state 24 hours, get the supernatant recovered alcohol and get Fructus Lycii, Radix Ophiopogonis extract in the alcohol amount of containing, standby; The extracting solution that makes in C, merging A, B two steps, further simmer down to proportion is the extractum of 1.2-1.3, drying and crushing; D, with the medicated powder of C step gained, add soybean isoflavone that is taken from Semen sojae atricolor and the procyanidin that is taken from Semen Vitis viniferae, and starch supplementary material, behind abundant stirring and evenly mixing,, make capsule, make tablet through tablet forming technique through filling process with ethanol granulation, drying.
3, a kind of health food that is used to improve female menopause symptoms according to claim 1, it is characterized in that: the content of the soybean isoflavone that is adopted is 40%; The content of the procyanidin that is adopted is 95%.
4, a kind of health food that is used to improve female menopause symptoms according to claim 1, it is characterized in that: described this health food is a kind of capsule-shaped food.
5, a kind of health food that is used to improve female menopause symptoms according to claim 1, it is characterized in that: described this health food is a kind of tablet food.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101066126B (en) * | 2007-01-24 | 2010-12-01 | 陈小保 | Health food suitable for middle aged and old women |
| CN101971988A (en) * | 2010-10-11 | 2011-02-16 | 孙羽蒙 | Prescription for treating female climacteric syndrome |
| CN101537079B (en) * | 2008-03-21 | 2011-06-08 | 北京润康普瑞生物技术有限公司 | Pharmaceutical composition or health-care product for improving sleeping and delaying senility and preparation method thereof |
| CN104083358A (en) * | 2014-07-31 | 2014-10-08 | 河南牧翔动物药业有限公司 | Application of proanthocyanidins to prepare medicines for resisting ageing of kidney tissue of livestock and poultry |
| CN104940241A (en) * | 2015-05-29 | 2015-09-30 | 湖北圣峰药业有限公司 | Selenium-containing cordyceps militaris compound preparation for preventing and treating female climacteric syndromes |
| CN107307398A (en) * | 2017-05-16 | 2017-11-03 | 柳州联云科技有限公司 | A kind of female health food |
Family Cites Families (3)
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| CN1169315A (en) * | 1996-06-27 | 1998-01-07 | 李彦伟 | Immunity-regulating health-care tea |
| CN1193750C (en) * | 2001-10-26 | 2005-03-23 | 牛建昭 | Medicine for treating menopausal syndrome |
| CN1259955C (en) * | 2001-12-06 | 2006-06-21 | 深圳太太药业有限公司 | Chinese medicine preparation for treating climacteric metancholia of women |
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- 2004-04-22 CN CNB2004100231318A patent/CN100382832C/en not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101066126B (en) * | 2007-01-24 | 2010-12-01 | 陈小保 | Health food suitable for middle aged and old women |
| CN101537079B (en) * | 2008-03-21 | 2011-06-08 | 北京润康普瑞生物技术有限公司 | Pharmaceutical composition or health-care product for improving sleeping and delaying senility and preparation method thereof |
| CN101971988A (en) * | 2010-10-11 | 2011-02-16 | 孙羽蒙 | Prescription for treating female climacteric syndrome |
| CN101971988B (en) * | 2010-10-11 | 2012-05-23 | 孙羽蒙 | Prescription for treating female climacteric syndrome |
| CN104083358A (en) * | 2014-07-31 | 2014-10-08 | 河南牧翔动物药业有限公司 | Application of proanthocyanidins to prepare medicines for resisting ageing of kidney tissue of livestock and poultry |
| CN104940241A (en) * | 2015-05-29 | 2015-09-30 | 湖北圣峰药业有限公司 | Selenium-containing cordyceps militaris compound preparation for preventing and treating female climacteric syndromes |
| CN104940241B (en) * | 2015-05-29 | 2018-09-21 | 湖北圣峰药业有限公司 | A kind of selenium worm grass compound preparation of prevention climacteric metancholia of women |
| CN107307398A (en) * | 2017-05-16 | 2017-11-03 | 柳州联云科技有限公司 | A kind of female health food |
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| CN100382832C (en) | 2008-04-23 |
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