CN103479831B - Pure Chinese medicine composition for the treatment of chicken infectious anemia and preparation method thereof - Google Patents
Pure Chinese medicine composition for the treatment of chicken infectious anemia and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of pure Chinese medicine composition for the treatment of chicken infectious anemia, its preparation method carries out as follows: (1) crosses 700 mesh sieves by after the various compositions in prescription respectively micronizing; (2) take Herba Ephedrae 15-35 part, Ramulus Cinnamomi 15-25 part, Rhizoma Atractylodis Macrocephalae 10-35 part, Radix Arnebiae (Radix Lithospermi) 15-30 part, Massa Medicata Fermentata 10-30 part, Radix Clematidis 10-30 part by weight, mix 5-10 minute to even; (3) take Fructus Crataegi 10-30 part, Petiolus Trachycarpi 15-45 part, Flos Sophorae 10-35 part, Radix Rehmanniae Preparata 10-35 part, Radix Glycyrrhizae 15-35 part, Folium Ilicis Cornutae 10-30 part by weight, mix 5-10 minute to even; (4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and said composition has no side effect, drug residue free, have no drug resistance, and micronizing, bioavailability are high, curative effect highly significant, and clinical proof has specially good effect to treatment chicken infectious anemia.
Description
Technical field
The present invention relates to pure Chinese medicine composition and preparation method thereof for the treatment of chicken infectious anemia, belong to field of animal, be particularly a kind ofly specifically designed to pure Chinese medicine composition for the treatment of chicken infectious anemia and preparation method thereof.
Background technology
Chicken infectious anemia is a kind of main infringement chickling caused by Chicken Anemia Virus (CAV) is main inhibitive ability of immunity and egg transmissibility infectious disease, with aplastic anemia and total lymphoid Telatrophy for principal character.The chicken of the various length of time and kind all can infect, and case fatality rate is generally between 5%-60%, can affect growth and the egg laying performance of poultry.This disease all can occur throughout the year, is one of principal disease of harm poultry husbandry.
The pathogen of primary disease is Chicken Anemia Virus (CAV), and virus resistance is to external world very strong.This disease is all poultry countries of throughout world almost, are widely distributed.At present, prevent and treat this disease the most frequently used be anti virus herb and Western medicine, Chinese medicine is because its prescription is unreasonable or just simply pulverize, and particle diameter is excessive, and drug release is comparatively slow, and cause its bioavailability lower, clinical effectiveness is not fine; And various antiviral drugs such as the Ministry of Agriculture such as ribavirin, amantadine prohibits the use.
Therefore research and develop and a kind ofly treat the drug residue free of chicken infectious anemia, the generation that has no drug resistance, the significant specific medicament of clinical effectiveness are one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, preparation is simple, micronizing, bioavailability are high, successful, to have no drug resistance and the pure Chinese medicine composition and preparation method thereof of effective treatment chicken infectious anemia of drug residue.
For achieving the above object, implementation of the present invention is as follows: a kind of pure Chinese medicine composition for the treatment of chicken infectious anemia, by following component by weight mixed preparing form: Herba Ephedrae 15-35 part, Ramulus Cinnamomi 15-25 part, Rhizoma Atractylodis Macrocephalae 10-35 part, Radix Arnebiae (Radix Lithospermi) 15-30 part, Massa Medicata Fermentata 10-30 part, Radix Clematidis 10-30 part, Fructus Crataegi 10-30 part, Petiolus Trachycarpi 15-45 part, Flos Sophorae 10-35 part, Radix Rehmanniae Preparata 10-35 part, Radix Glycyrrhizae 15-35 part, Folium Ilicis Cornutae 10-30 part.
On the basis of such scheme, described various component optimum ratio amount is: 25 parts, Herba Ephedrae, Ramulus Cinnamomi 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, Massa Medicata Fermentata 20 parts, Radix Clematidis 20 parts, Fructus Crataegi 20 parts, 30 parts, Petiolus Trachycarpi, 25 parts, Flos Sophorae, Radix Rehmanniae Preparata 25 parts, 25 parts, Radix Glycyrrhizae, Folium Ilicis Cornutae 20 parts.
Treat a preparation method for the pure Chinese medicine composition of chicken infectious anemia, carry out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take by weight and get Herba Ephedrae 15-35 part, Ramulus Cinnamomi 15-25 part, Rhizoma Atractylodis Macrocephalae 10-35 part, Radix Arnebiae (Radix Lithospermi) 15-30 part, Massa Medicata Fermentata 10-30 part, Radix Clematidis 10-30 part, mix 5-10 minute to evenly;
(3) take Fructus Crataegi 10-30 part, Petiolus Trachycarpi 15-45 part, Flos Sophorae 10-35 part, Radix Rehmanniae Preparata 10-35 part, Radix Glycyrrhizae 15-35 part, Folium Ilicis Cornutae 10-30 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
The medicinal property of each component is as follows:
Radix Clematidis: become, temperature, pungent, return urinary bladder channel, there is the function of wind-damp dispelling, the meridian dredging; Cure mainly rheumatic arthralgia, the contracture of muscle arteries and veins, joint stuffiness etc.
Folium Ilicis Cornutae: bitter, cool, returns liver, kidney channel, has the function of replenishing YIN and removing heat, invigorating function of kidney and strengthening bone; Cure mainly yin asthenia generating intrinsic heat, cough, waist hip unable etc.
Herba Ephedrae: micro-hardship, temperature, pungent, returns lung, urinary bladder channel, has the function of the cold expelling that induces sweat, depressed lung-energy dispersing, inducing diuresis to remove edema; Cure mainly affection of exogenous wind-cold, cough, asthma, edema etc.
Ramulus Cinnamomi: sweet, pungent, warm, returns lung, the heart, urinary bladder channel, has the function of diaphoresis expelling pathogenic factors from muscles, warming the meridian for promoting the flow of YANG QI; Cure mainly wind and cold sign, arthralgia, retention of water-damp etc.
The Rhizoma Atractylodis Macrocephalae: sweet, bitter, warm, returns spleen, stomach warp, has the function of spleen reinforcing stomach invigorating, dampness diuretic, antiabortive, hidroschesis; Cure mainly diarrhea due to hypofunction of the spleen, tripe opened, edema, sweating due to debility, frequent fetal movement etc.
Radix Arnebiae (Radix Lithospermi): sweet, become, cold, return liver, heart channel, there is the function of removing heat from blood and promoting blood circulation, removing toxic substances speckle removing; Cure mainly heat in blood poison Sheng, pyretic toxicity ecchymosis, eczema etc.
Radix Rehmanniae Preparata: sweet, tepor, returns liver, kidney channel, has nourishing YIN and supplementing blood, a function that beneficial essence fills out marrow; Cure mainly that the hepatic and renal YIN deficiency, blood deficiency damage of essence, waist hip flaccidity are soft, dyspnea due to deficiency chronic cough, deficiency-heat night sweat etc.
Fructus Crataegi: sour, sweet, tepor, returns stomach, spleen, Liver Channel, has the function of promoting digestion and removing stagnation, circulation of qi promoting dissipating blood stasis; Cure mainly dyspeptic abdominal flatulence, dyspepsia, prolonged lochia etc.
Massa Medicata Fermentata: sweet, pungent, warm, returns stomach, spleen channel, has invigorating the spleen and regulating the stomach, help digestion the function in adjusting; Cure mainly that food stagnation does not disappear, tripe is swollen, postnatal blood stasis stomachache etc.
Petiolus Trachycarpi: bitter, puckery, flat, returns lung, liver, large intestine channel, has the function of hemostasis with astringents; Cure mainly epistaxis, have blood in stool, hematuria, metrorrhagia etc.
Flos Sophorae: bitter, be slightly cold, returns liver, large intestine channel, has the function of purging liver-fire, removing heat from blood, hemostasis, dysentery relieving; Cure mainly have blood in stool, dysentery, piglet pujos blancos, postpartum hemorrhage, wind heat conjunctival congestion etc.
Radix Glycyrrhizae: sweet, flat, returns lung, the heart, spleen channel, has invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
All taste Chinese medicine is according to Chinese medical theory compatible combination above, for clinical symptoms and the pathological change of chicken infectious anemia, plays the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and draw materials wide, micronizing, bioavailability are high, can also can drink water by spice, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this 12 taste Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, specially good effect is had to treatment chicken infectious anemia, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively ensure that people's is healthy.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of chicken infectious anemia and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take by weight and get 150 parts, Herba Ephedrae, Ramulus Cinnamomi 150 parts, the Rhizoma Atractylodis Macrocephalae 100 parts, Radix Arnebiae (Radix Lithospermi) 150 parts, Massa Medicata Fermentata 100 parts, Radix Clematidis 100 parts, mix 5-10 minute to evenly;
(3) take Fructus Crataegi 100 parts, 150 parts, Petiolus Trachycarpi, 100 parts, Flos Sophorae, Radix Rehmanniae Preparata 100 parts, 150 parts, Radix Glycyrrhizae, Folium Ilicis Cornutae 100 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of chicken infectious anemia and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take by weight and get 250 parts, Herba Ephedrae, Ramulus Cinnamomi 200 parts, the Rhizoma Atractylodis Macrocephalae 150 parts, Radix Arnebiae (Radix Lithospermi) 200 parts, Massa Medicata Fermentata 200 parts, Radix Clematidis 200 parts, mix 5-10 minute to evenly;
(3) take Fructus Crataegi 200 parts, 300 parts, Petiolus Trachycarpi, 250 parts, Flos Sophorae, Radix Rehmanniae Preparata 250 parts, 250 parts, Radix Glycyrrhizae, Folium Ilicis Cornutae 200 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 3
A kind of composition and method of making the same for the treatment of chicken infectious anemia: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take by weight and get 350 parts, Herba Ephedrae, Ramulus Cinnamomi 250 parts, the Rhizoma Atractylodis Macrocephalae 350 parts, Radix Arnebiae (Radix Lithospermi) 300 parts, Massa Medicata Fermentata 300 parts, Radix Clematidis 300 parts, mix 5-10 minute to evenly;
(3) take Fructus Crataegi 300 parts, 450 parts, Petiolus Trachycarpi, 350 parts, Flos Sophorae, Radix Rehmanniae Preparata 350 parts, 350 parts, Radix Glycyrrhizae, Folium Ilicis Cornutae 300 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 20 ages in days, body weight at 0.9kg-1.0kg, and Laboratory Diagnosed is the ill chicken of chicken infectious anemia.Ill chicken isolation raised separately, complete feed of feeding, and be divided into 3 groups at random, often organize 100,3 groups of feeding environments are identical, and experimental period carries out 7 days altogether; Blank group is left intact, and drug control group institute's control drug uses treatment by its description; Present composition group by the ill chicken of product of the present invention (compositions obtained by the embodiment of the present invention 2) feeding, day dose be: 350 kilograms are fed or drunk water to every 100 grams of present composition spices 200 kilograms, every day 1-2 time; Reached the object of disease therapy by gastrointestinal absorption after oral.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result (testing the 7th day) at the end of experiment.
Efficacy assessment standard:
Cure: spirit is normal, drinking-water of searching for food is normal, and feces is normal, and beak, wattle and visual mucosa, wing etc. are normal, bouncing, cuts open inspection fabricius bursa, spleen, caecum, tonsil and other organs etc. normal.
At the end of have symptom: clinical symptoms is not improved and is even increased the weight of.
Table is that the Field information situation that the present invention and other medicines treat chicken infectious anemia contrasts:
| Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
| I | Blank group | 13 | 22 | 65 |
| II | Chicken infectious anemia falls apart group | 8 | 71 | 21 |
| III | Chinese medicine composition group of the present invention | 6 | 81 | 13 |
This clinical effectiveness statistical analysis, present composition group and chicken infectious anemia fall apart group in cure rate compared with difference extremely significantly (P < 0.01).
Safety testing:
Choose 20 age in days healthy chicken 60, according to the made pure Chinese medicine composition recommended dose of the embodiment of the present invention 25 times of spices or drinking-water 5 days, during medication, healthy chicken is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.
Above-mentioned detailed description of pure Chinese medicine composition of this treatment chicken infectious anemia and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (2)
1. treat a pure Chinese medicine composition for chicken infectious anemia, it is characterized in that by following component by weight mixed preparing form: Herba Ephedrae 15-35 part, Ramulus Cinnamomi 15-25 part, Rhizoma Atractylodis Macrocephalae 10-35 part, Radix Arnebiae (Radix Lithospermi) 15-30 part, Massa Medicata Fermentata 10-30 part, Radix Clematidis 10-30 part, Fructus Crataegi 10-30 part, Petiolus Trachycarpi 15-45 part, Flos Sophorae 10-35 part, Radix Rehmanniae Preparata 10-35 part, Radix Glycyrrhizae 15-35 part, Folium Ilicis Cornutae 10-30 part;
Preparation method is carried out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take by weight and get Herba Ephedrae 15-35 part, Ramulus Cinnamomi 15-25 part, Rhizoma Atractylodis Macrocephalae 10-35 part, Radix Arnebiae (Radix Lithospermi) 15-30 part, Massa Medicata Fermentata 10-30 part, Radix Clematidis 10-30 part, mix 5-10 minute to evenly;
(3) take Fructus Crataegi 10-30 part, Petiolus Trachycarpi 15-45 part, Flos Sophorae 10-35 part, Radix Rehmanniae Preparata 10-35 part, Radix Glycyrrhizae 15-35 part, Folium Ilicis Cornutae 10-30 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
2. the pure Chinese medicine composition for the treatment of chicken infectious anemia according to claim 1, is characterized in that described various component optimum ratio amount is: 25 parts, Herba Ephedrae, Ramulus Cinnamomi 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, Massa Medicata Fermentata 20 parts, Radix Clematidis 20 parts, Fructus Crataegi 20 parts, 30 parts, Petiolus Trachycarpi, 25 parts, Flos Sophorae, Radix Rehmanniae Preparata 25 parts, 25 parts, Radix Glycyrrhizae, Folium Ilicis Cornutae 20 parts.
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| CN103479831B true CN103479831B (en) | 2015-09-16 |
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| CN103931957B (en) * | 2014-05-13 | 2015-07-01 | 山东新希望六和集团有限公司 | Chicken feed and traditional Chinese medicine composition for preventing and treating chicken infectious anemia |
| CN105079303A (en) * | 2015-09-28 | 2015-11-25 | 宋磊 | Medicine for preventing and curing Chicken infectious anemia |
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| CN102397528B (en) * | 2011-11-15 | 2013-10-30 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating chicken infectious anemia and preparation method thereof |
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