CN102935139A - Compound propolis composition for treating chronic gastroenteritis of livestock and preparation method of composition - Google Patents
Compound propolis composition for treating chronic gastroenteritis of livestock and preparation method of composition Download PDFInfo
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- CN102935139A CN102935139A CN2012105100825A CN201210510082A CN102935139A CN 102935139 A CN102935139 A CN 102935139A CN 2012105100825 A CN2012105100825 A CN 2012105100825A CN 201210510082 A CN201210510082 A CN 201210510082A CN 102935139 A CN102935139 A CN 102935139A
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Abstract
The invention relates to a compound propolis composition for treating chronic gastroenteritis of livestock. The compound propolis composition is prepared by mixing the following components in parts by weight: 15-35 parts of propolis, 15-25 parts of Chinese Pulsatilla root, 15-40 parts of felwort, 10-40 parts of coptis chinensis, 15-35 parts of oriental wormwood, 15-25 parts of officinal magnolia bark, 15-35 parts of rheum officinale, 25-55 parts of hawthorn, 15-35 parts of Eclipta alba and 15-35 parts of houttuynia cordata. The compound propolis composition has the beneficial effects that prescription is reasonable, preparation is simple; the composition has no toxic and side effects, is free from pollution, medicament residues and medicament resistance, high in bioavailability and extremely obvious in curative effect, is subjected to superfine grinding; and by clinic, the compound propolis composition has special effect for treating the chronic gastroenteritis of the livestock.
Description
Technical field
The present invention relates to compound bee-glue composition for the treatment of the domestic animal chronic gastroenteritis and preparation method thereof, belong to the animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment domestic animal chronic gastroenteritis and preparation method thereof.
Background technology
The domestic animal chronic gastroenteritis is the chronic inflammatory disease of its gastrointestinal top layer mucosa and deep tissues thereof, and main manifestations is that disease is just spiritual depressed clinically, and inappetence, body temperature are slightly high, are hard and dry.The middle and late stage tired mind likes to drink cold water, and the burnt abdomen of hair hangs, and the eye conjunctiva is crimson, and defecating is the sposh shape, and excrement contains mucus or blood and intestinal mucosa, and abnormal smells from the patient is stench, collapses, dies of exhaustion and die because of dehydration at last.Cut open inspection visible gastrointestinal inwall hyperemia or ulcer, intestinal wall attenuation, small intestinal flatulence.Malpractice causes death easily, causes larger economic loss to aquaculture.Primary disease all can occur throughout the year, and mortality rate is very high, is generally between the 5%-16%.
Western medical treatment mainly is to clear up gastrointestinal, anti-inflammation, and poisoning etc. is removed in the heart tonifying fluid infusion, and though receive certain effect, the course of disease is dragged longly, and medical expense is too high, and therapeutic effect still can not be satisfactory.And the traditional Chinese medical science thinks that primary disease mainly is to accumulate the infringement intestinal in the damp and hot heresy, and QI and blood hinders and causes that more serious inflammatory disorders occurs the gastrointestinal mucosa deep layer, and Chinese veterinarian is referred to as " intestinal is yellow ".The rule for the treatment of take heat-clearing and toxic substances removing, logical intestinal intestinal stasis relieving, strengthening the spleen and nourishing the stomach, efface the pernicious influence as the rule for the treatment of.
This disease almost spreads all over all livestock culturing countries of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing the just, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And Western medicine by force, easily produces the problems such as drug resistance and drug residue owing to its toxic and side effects, and clinical practice is very limited or bans use of.
Therefore research and develop that a kind of to treat the having no side effect of domestic animal chronic gastroenteritis, drug residue free, the specific medicament that produces that has no drug resistance be one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability height, successful, have no side effect, have no drug resistance and effective compound bee-glue composition for the treatment of the domestic animal chronic gastroenteritis of drug residue and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of the domestic animal chronic gastroenteritis, by following component by weight mixed preparing form: propolis 15-35 part, Radix Pulsatillae 15-25 part, Radix Gentianae 15-40 part, Rhizoma Coptidis 10-40 part, Herba Artemisiae Scopariae 15-35 part, Cortex Magnoliae Officinalis 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Crataegi 25-55 part, Herba Ecliptae 15-35 part, Herba Houttuyniae 15-35 part.
Described various component optimum ratio amount is: 25 parts of propolis, 20 parts of the Radix Pulsatillaes, 25 parts of Radix Gentianaes, 25 parts of Rhizoma Coptidis, 25 parts of Herba Artemisiae Scopariaes, 25 parts of Cortex Magnoliae Officinalis, 25 parts of Radix Et Rhizoma Rhei, 40 parts of Fructus Crataegis, 25 parts of Herba Ecliptaes, 25 parts of Herba Houttuyniae.
A kind of preparation method for the treatment of the compound bee-glue composition of domestic animal chronic gastroenteritis is characterized in that carrying out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight propolis 15-35 part, Radix Pulsatillae 15-25 part, Radix Gentianae 15-40 part, Rhizoma Coptidis 10-40 part, Herba Artemisiae Scopariae 15-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Cortex Magnoliae Officinalis 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Crataegi 25-55 part, Herba Ecliptae 15-35 part, Herba Houttuyniae 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, hot, cold, return spleen, lung, stomach warp, have anti-bacteria and anti-virus, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic oxidation, stop blooding, moisturize, the function of relieving cough and asthma, protection gastrointestinal mucosa etc.
The Radix Pulsatillae: bitter, cold, return stomach, large intestine channel, have the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly toxic-heat and blood stasis, damp and hot intestinal Huang etc.
Radix Gentianae: bitter, cold, return liver, gallbladder meridian, have eliminating pathogen in the liver gallbladder excess-fire, except the function of damp-heat in lower-JIAO; Cure mainly jaundice due to damp-heat, conjunctival congestion and swelling pain, eczema pruritus etc.
Rhizoma Coptidis: bitter, cold, return spleen, stomach, large intestine, gallbladder, heart channel, have the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder etc.
Herba Artemisiae Scopariae: bitter, hot, be slightly cold, return, spleen, stomach, gallbladder, Liver Channel, have the function of clearing away heat-damp and promoting diuresis, promoting the function of the gallbladder to alleviate jaundice; Cure mainly jaundice, oliguria, eczema pruritus etc.
Mangnolia officinalis: bitter, hot, warm, return spleen, stomach, lung, large intestine channel, have the function of therapeutic method to keep the adverse QI flowing downwards relieving distension, dampness expectorant; Cure mainly that dyspepsia does not disappear, stagnation of QI due to dyspepsia, the swollen constipation of tripe, phlegm retention cough with asthma etc.
Radix Et Rhizoma Rhei: bitter, cold, return large intestine, spleen, stomach, liver, pericardium channel, have the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass blood stasis expelling; Cure mainly excess-heat constipation, combined symptoms, the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain, enteritis etc.
Fructus Crataegi: sour, sweet, tepor, return stomach, spleen, Liver Channel, have the function of promoting digestion and removing stagnation, circulation of qi promoting dissipating blood stasis; Cure mainly dyspeptic abdominal flatulence, dyspepsia, prolonged lochia etc.
Herba Ecliptae: sweet, sour, cold, return liver, kidney channel, have the functions such as cooling blood for hemostasis, the kidney invigorating tonifying YIN, cure mainly dysentery, intestinal Huang etc.
Herba Houttuyniae: hot, be slightly cold, return lung meridian, have the functions such as heat-clearing and toxic substances removing, detumescence and apocenosis, inducing diuresis for treating stranguria syndrome, cure mainly dysentery, intestinal Huang, lung abscess, acute mastitis, stranguria with turbid discharge etc.
More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, for paathogenic factor and the clinical symptoms of domestic animal chronic gastroenteritis, the performance treating both the principal and secondary aspects of a disease effect.The Radix Pulsatillae in this prescription, Rhizoma Coptidis, Radix Gentianae have heat-clearing and toxic substances removing, removing heat from blood to control dysentery to act as principal agent; Fructus Crataegi, Cortex Magnoliae Officinalis, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei share has logical intestinal intestinal stasis relieving, the drying damp and strengthening spleen accessory drugs that act as; Propolis, Herba Ecliptae, Herba Houttuyniae have removing heat from blood, disinfecting detoxifying to act as adjuvant drug.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, treatment domestic animal chronic gastroenteritis there is specially good effect, and make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of compound bee-glue composition for the treatment of the domestic animal chronic gastroenteritis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 150 parts of propolis, 150 parts of the Radix Pulsatillaes, 150 parts of Radix Gentianaes, 100 parts of Rhizoma Coptidis, 150 parts of Herba Artemisiae Scopariaes, mix 5-10 minute to even;
(3) take by weighing by weight 150 parts of Cortex Magnoliae Officinalis, 150 parts of Radix Et Rhizoma Rhei, 250 parts of Fructus Crataegis, 150 parts of Herba Ecliptaes, 150 parts of Herba Houttuyniae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of the domestic animal chronic gastroenteritis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 250 parts of propolis, 200 parts of the Radix Pulsatillaes, 250 parts of Radix Gentianaes, 250 parts of Rhizoma Coptidis, 250 parts of Herba Artemisiae Scopariaes, mix 5-10 minute to even;
(3) take by weighing by weight 250 parts of Cortex Magnoliae Officinalis, 250 parts of Radix Et Rhizoma Rhei, 400 parts of Fructus Crataegis, 250 parts of Herba Ecliptaes, 250 parts of Herba Houttuyniae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of the domestic animal chronic gastroenteritis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 350 parts of propolis, 250 parts of the Radix Pulsatillaes, 400 parts of Radix Gentianaes, 400 parts of Rhizoma Coptidis, 350 parts of Herba Artemisiae Scopariaes, mix 5-10 minute to even;
(3) take by weighing by weight 350 parts of Cortex Magnoliae Officinalis, 350 parts of Radix Et Rhizoma Rhei, 550 parts of Fructus Crataegis, 350 parts of Herba Ecliptaes, 350 parts of Herba Houttuyniae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
The clinical experiment animal selects 75-85 age in days, body weight at 30kg-40kg, is diagnosed as the ill pig of pig chronic gastroenteritis.Ill pig isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experiment was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with " the dysentery health is loose " by specification; Chinese medicine composition group of the present invention can be with product of the present invention (embodiment of the invention 1 prepared compositions) the ill pig of feeding, and a day dose is: 250kg feeds by the every 100g spice of the present invention, every day 2-3 time, is used in conjunction 3-5 day; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table is the field applicable cases contrast of the present invention and other medicines treatment pig chronic gastroenteritis:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 10.0 | 56.7 | 33.3 |
| II | The loose group of dysentery health | 6.7 | 83.3 | 10.0 |
| III | Present composition group | 0 | 93.3 | 6.7 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared significant difference (P＜0.05) with the loose group of dysentery health aspect the cure rate.
Safety testing:
Choose 10 of 70 age in days health pig, 5 times of spices according to the embodiment of the invention 1 made compositions recommended dose were fed 10 days, during the medication, health pig is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of compound bee-glue composition of this treatment domestic animal chronic gastroenteritis and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. compound bee-glue composition for the treatment of the domestic animal chronic gastroenteritis, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Radix Pulsatillae 15-25 part, Radix Gentianae 15-40 part, Rhizoma Coptidis 10-40 part, Herba Artemisiae Scopariae 15-35 part, Cortex Magnoliae Officinalis 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Crataegi 25-55 part, Herba Ecliptae 15-35 part, Herba Houttuyniae 15-35 part.
2. the compound bee-glue composition for the treatment of according to claim 1 domestic animal chronic gastroenteritis, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 20 parts of the Radix Pulsatillaes, 25 parts of Radix Gentianaes, 25 parts of Rhizoma Coptidis, 25 parts of Herba Artemisiae Scopariaes, 25 parts of Cortex Magnoliae Officinalis, 25 parts of Radix Et Rhizoma Rhei, 40 parts of Fructus Crataegis, 25 parts of Herba Ecliptaes, 25 parts of Herba Houttuyniae.
3. the preparation method of the compound bee-glue composition of a treatment according to claim 1 and 2 domestic animal chronic gastroenteritis is characterized in that carrying out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight propolis 15-35 part, Radix Pulsatillae 15-25 part, Radix Gentianae 15-40 part, Rhizoma Coptidis 10-40 part, Herba Artemisiae Scopariae 15-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Cortex Magnoliae Officinalis 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Crataegi 25-55 part, Herba Ecliptae 15-35 part, Herba Houttuyniae 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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Cited By (2)
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| CN106334075A (en) * | 2016-11-07 | 2017-01-18 | 四会市恒星智能科技有限公司 | Traditional Chinese veterinary medicine for preventing and treating intestinal diseases of fragrant pigs and preparation method thereof |
| CN116966230A (en) * | 2023-09-11 | 2023-10-31 | 山东利邦牧业股份有限公司 | Fermented traditional Chinese medicine composition for preventing and controlling porcine reproductive and respiratory syndrome as well as preparation method and application thereof |
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| CN106334075A (en) * | 2016-11-07 | 2017-01-18 | 四会市恒星智能科技有限公司 | Traditional Chinese veterinary medicine for preventing and treating intestinal diseases of fragrant pigs and preparation method thereof |
| CN116966230A (en) * | 2023-09-11 | 2023-10-31 | 山东利邦牧业股份有限公司 | Fermented traditional Chinese medicine composition for preventing and controlling porcine reproductive and respiratory syndrome as well as preparation method and application thereof |
| CN116966230B (en) * | 2023-09-11 | 2024-04-19 | 山东利邦牧业股份有限公司 | Fermented traditional Chinese medicine composition for preventing and controlling porcine reproductive and respiratory syndrome as well as preparation method and application thereof |
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Application publication date: 20130220 |