CN103041047B - Compound propolis composition for treating ox influenza and preparation method thereof - Google Patents

Abstract

The invention relates to a compound propolis composition for treating ox influenza, which is prepared by mixing the following components in part by weight: 15 to 35 parts of propolis, 15 to 35 parts of fennel, 15 to 35 parts of rhizoma atractylodis, 15 to 35 parts of gentiana macrophylla, 10 to 35 parts of cortex acanthopanacis, 15 to 35 parts of white paeony root, 15 to 40 parts of liquorice, 15 to 45 parts of tangerine peel, 15 to 45 parts of cassia twig and 15 to 45 parts of folium isatidis. The compound propolis composition has the benefits that the compound propolis composition has reasonable composition, is simple to prepare, has no toxic or side effect, has no pollution, has no drug residues, has no drug resistance, is superfinely ground, has high bioavailability and has very obvious curative effects; and clinical application proves that the compound propolis composition has a special effect of treating ox influenza.

Description

Compound bee-glue composition for the treatment of ox influenza and preparation method thereof

Technical field

The present invention relates to compound bee-glue composition and preparation method thereof for the treatment of ox influenza, belong to field of animal, be particularly a kind ofly specifically designed to compound bee-glue composition for the treatment of ox influenza and preparation method thereof.

Background technology

Ox influenza is by being the acute febrile illness being feature with fever with aversion to cold, watery nasal discharge, cough that body causes by cold invasion and attack suddenly.More with young stock morbidity, the multiple season being born in early spring and temperature cataclysm in late fall.The Niu Junke of various age and kind occurs, and sickness rate is up to more than 20%, and mortality rate, below 5%, is one of principal disease of serious harm cattle-raising.

This disease is all cowboying countries of throughout world almost, are widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug and antipyretic analgesic medicine, Chinese medicine is because its prescription is unreasonable or just simply pulverize, and particle diameter is excessive, and drug release is comparatively slow, and cause its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug and antipyretic analgesic have drug residue due to life-time service and easily produce drug resistance, its clinical effectiveness worse and worse, and drug residue causes outlet limited healthy with harm people, thus makes the use of antimicrobial drug and antipyretic analgesic be very restricted.

Therefore researching and developing a kind of drug residue free, specific medicament of producing of having no drug resistance for the treatment of ox influenza is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, preparation is simple, micronizing, bioavailability are high, successful, to have no drug resistance and the compound bee-glue composition and preparation method thereof of effective treatment ox influenza of drug residue.

Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of ox influenza, by following component by weight mixed preparing form: propolis 15-35 part, Fructus Foeniculi 15-35 part, Rhizoma Atractylodis 15-35 part, Radix Gentianae Macrophyllae 15-35 part, Cortex Acanthopancis 10-35 part, Radix Paeoniae Alba 15-35 part, Radix Glycyrrhizae 15-40 part, Pericarpium Citri Reticulatae 15-45 part, Ramulus Cinnamomi 15-45 part, Folium Isatidis 15-45 part.

Described various component optimum ratio amount is: propolis 25 parts, 25 parts, Fructus Foeniculi, Rhizoma Atractylodis 25 parts, Radix Gentianae Macrophyllae 25 parts, Cortex Acanthopancis 25 parts, the Radix Paeoniae Alba 25 parts, 30 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 30 parts, Ramulus Cinnamomi 30 parts, Folium Isatidis 30 parts.

Treat a preparation method for the compound bee-glue composition of ox influenza, carry out as follows:

(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;

(2) take propolis 15-35 part, Fructus Foeniculi 15-35 part, Rhizoma Atractylodis 15-35 part, Radix Gentianae Macrophyllae 15-35 part, Cortex Acanthopancis 10-35 part by weight, mix 5-10 minute to even;

(3) take Radix Paeoniae Alba 15-35 part, Radix Glycyrrhizae 15-40 part, Pericarpium Citri Reticulatae 15-45 part, Ramulus Cinnamomi 15-45 part, Folium Isatidis 15-45 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.

The medicinal property of each component is as follows:

Propolis: bitter, acrid, cold, returns spleen, stomach warp, has anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improves immunity, antiallergic is oxidized, the function of the gastrointestinal mucosa that stops blooding, protects.

Fructus Foeniculi: warm, pungent, returns liver,kidney,spleen, stomach warp.There is the function of warming the liver kidney, warming the stomach gas, loose plug knot, dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach; Cure mainly the disease such as colic of cold type stomachache, few abdomen cold type of pain, abdominal distention, lack of appetite and vomiting.

Rhizoma Atractylodis: acrid, bitter, warm, return spleen, stomach, Liver Channel, have drying damp and strengthening spleen, expelling wind and cold, improving eyesight, function; Cure mainly have loose bowels, edema, anemofrigid-damp arthralgia, anemofrigid cold, nyctalopia etc.

Radix Gentianae Macrophyllae: pungent, bitter, flat, returns gallbladder, stomach, Liver Channel, has the function of wind-damp dispelling, stopping numbness pain, reducing the asthenic fever; Cure mainly rheumatic arthralgia, the contracture of muscle arteries and veins, anemofrigid-damp arthralgia, fever due to yin deficiency, hematuria etc.

Cortex Acanthopancis: bitter, pungent, warm, returns liver, kidney channel, has the function of expelling wind and removing dampness, bone and muscle strengthening, liver and kidney tonifying, inducing diuresis to remove edema; Cure mainly anemofrigid-damp arthralgia, waist flaccidity be soft, the deficiency of vital energy is weak, edema etc.

The Radix Paeoniae Alba: bitter, acid, to be slightly cold, returns liver, spleen channel, has suppressing the hyperactive liver pain relieving, the function of the yin fluid astringing that nourishes blood; Cure mainly deficiecny of liver-YIN, deficiency-heat, dysentery stomachache, spasm of the limbs etc.

Radix Glycyrrhizae: sweet, flat, returns lung, the heart, spleen channel, has invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning.

Ramulus Cinnamomi: sweet, pungent, warm, returns lung, the heart, urinary bladder channel, has the function of diaphoresis expelling pathogenic factors from muscles, warming the meridian for promoting the flow of YANG QI; Cure mainly wind and cold sign, arthralgia, retention of water-damp etc.

Pericarpium Citri Reticulatae: bitter, pungent, warm, returns lung, spleen channel, has the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe be swollen, have loose bowels, productive cough due to phlegm-damp etc.

Folium Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly calentura and send out speckle, laryngopharynx swelling and pain, hematodiarrhoea, jaundice, carbuncle, erysipelas etc.

All taste Chinese medicine is according to Chinese medical theory compatible combination above, for clinical symptoms and the pathological change of ox influenza, plays the effect for the treatment of both the principal and secondary aspects of a disease.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and draw materials wide, micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, specially good effect is had to treatment ox influenza, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively ensure that people's is healthy.

Detailed description of the invention

Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:

Embodiment 1

A kind of compound bee-glue composition for the treatment of ox influenza and preparation method thereof: carry out as follows: (every part by 10g)

(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;

(2) take propolis 150 parts, 150 parts, Fructus Foeniculi, Rhizoma Atractylodis 150 parts, Radix Gentianae Macrophyllae 150 parts, Cortex Acanthopancis 100 parts by weight, mix 5-10 minute to even;

(3) take the Radix Paeoniae Alba 150 parts, 150 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 150 parts, Ramulus Cinnamomi 150 parts, Folium Isatidis 150 parts by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.

Embodiment 2

A kind of compound bee-glue composition for the treatment of ox influenza and preparation method thereof: carry out as follows: (every part by 10g)

(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;

(2) take propolis 250 parts, 250 parts, Fructus Foeniculi, Rhizoma Atractylodis 250 parts, Radix Gentianae Macrophyllae 250 parts, Cortex Acanthopancis 250 parts by weight, mix 5-10 minute to even;

(3) take the Radix Paeoniae Alba 250 parts, 250 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 300 parts, Ramulus Cinnamomi 300 parts, Folium Isatidis 300 parts by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.

Embodiment 3

A kind of compound bee-glue composition for the treatment of ox influenza and preparation method thereof: carry out as follows: (every part by 10g)

(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;

(2) take propolis 350 parts, 350 parts, Fructus Foeniculi, Rhizoma Atractylodis 350 parts, Radix Gentianae Macrophyllae 350 parts, Cortex Acanthopancis 350 parts by weight, mix 5-10 minute to even;

(3) take the Radix Paeoniae Alba 350 parts, 400 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 450 parts, Ramulus Cinnamomi 450 parts, Folium Isatidis 450 parts by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.

Clinical trial:

Clinical experiment animal selects 200-250 age in days, and Laboratory Diagnosed is the beef cattle of ox influenza, is isolated and raises separately, complete feed of feeding, and be divided into 3 groups at random, and often organize 10,3 groups of feeding environments are identical, and test period is 7 days; Blank group is left intact, and drug control group " cattle GANKANG is fallen apart " by specification uses treatment; Chinese medicine composition group of the present invention can by product of the present invention (compositions obtained by the embodiment of the present invention 1) the ill cattle of feeding etc., day dose be: boiled water soaks, and waits temperature and gavages, by each 160g of product of the present invention, every day 1 time, be used in conjunction 3-5 day; Reached the object of disease therapy by gastrointestinal absorption after oral.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result (testing the 7th day) at the end of experiment.

Table is that the situation that the present invention and other medicines treat ox influenza contrasts:

Numbering	Group	Mortality rate %	Cure rate %	At the end of have symptom rate %
					I	Blank group	10.0	60.0	30.0
II	Cattle GANKANG is fallen apart group	0.0	80.0	20.0
					III	Present composition group	0.0	90.0	10.0

This clinical effectiveness statistical analysis, present composition treatment group and cattle GANKANG fall apart group in cure rate compared with difference extremely significantly (P < 0.01).

Safety testing:

Choose the healthy beef cattle 10 of 150 ages in days, 5 times according to the made compositions recommended dose of the embodiment of the present invention 1 gavage 5 days, during medication, healthy beef cattle is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.

Above-mentioned detailed description of compound bee-glue composition of this treatment ox influenza and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.

Claims (3)

1. treat a compound bee-glue composition for ox influenza, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Fructus Foeniculi 15-35 part, Rhizoma Atractylodis 15-35 part, Radix Gentianae Macrophyllae 15-35 part, Cortex Acanthopancis 10-35 part, Radix Paeoniae Alba 15-35 part, Radix Glycyrrhizae 15-40 part, Pericarpium Citri Reticulatae 15-45 part, Ramulus Cinnamomi 15-45 part, Folium Isatidis 15-45 part.

2. the compound bee-glue composition for the treatment of ox influenza according to claim 1, it is characterized in that by following component by weight mixed preparing form: propolis 25 parts, 25 parts, Fructus Foeniculi, Rhizoma Atractylodis 25 parts, Radix Gentianae Macrophyllae 25 parts, Cortex Acanthopancis 25 parts, the Radix Paeoniae Alba 25 parts, 30 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 30 parts, Ramulus Cinnamomi 30 parts, Folium Isatidis 30 parts.

3. a preparation method for the compound bee-glue composition for the treatment of ox influenza according to claim 1, is characterized in that carrying out as follows:

(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;

(2) take propolis 15-35 part, Fructus Foeniculi 15-35 part, Rhizoma Atractylodis 15-35 part, Radix Gentianae Macrophyllae 15-35 part, Cortex Acanthopancis 10-35 part by weight, mix 5-10 minute to even;

(3) take Radix Paeoniae Alba 15-35 part, Radix Glycyrrhizae 15-40 part, Pericarpium Citri Reticulatae 15-45 part, Ramulus Cinnamomi 15-45 part, Folium Isatidis 15-45 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.