CN104740714B - Implanted self energizing insulin pump - Google Patents
Implanted self energizing insulin pump Download PDFInfo
- Publication number
- CN104740714B CN104740714B CN201310733133.5A CN201310733133A CN104740714B CN 104740714 B CN104740714 B CN 104740714B CN 201310733133 A CN201310733133 A CN 201310733133A CN 104740714 B CN104740714 B CN 104740714B
- Authority
- CN
- China
- Prior art keywords
- power generation
- main body
- generation main
- self energizing
- insulin pump
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14212—Pumping with an aspiration and an expulsion action
- A61M5/14216—Reciprocating piston type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0272—Electro-active or magneto-active materials
- A61M2205/0294—Piezoelectric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/04—General characteristics of the apparatus implanted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/201—Glucose concentration
Abstract
The present invention provides a kind of implanted self energizing insulin pump, including blood sugar monitoring portion, the syringe pump of insulin injection, infusion catheter, control unit and Power Generation Section.Power Generation Section includes power generation main body, output unit, energy storage unit, fixed cell and encapsulated layer.Wherein, power generation main body is multi-layer film structure, includes the piezoelectric material layer positioned at power generation main body center, and the electrode layer positioned at piezoelectric material layer both sides, and the power generation main body acquires cardiac energy for producing electricl energy by being attached at heart surface.Output unit is connected with electrode layer, and the electric current that power generation main body generates is exported to energy storage unit.Fixed cell is located at the edge of power generation main body, for power generation main body to be fixed on the external membrane of heart.Encapsulated layer is covered in the surface of power generation main body, output unit, energy storage unit and fixed cell.The implanted self energizing insulin pump of the present invention can use all the life without battery is needed to change.
Description
Technical field
The present invention relates to a kind of implantable insulin pumps, belong to medical instruments field.
Background technology
Diabetes are the common disease and frequently-occurring disease of middle-older patient, as a kind of lifelong disease, are still lacked at present thoroughly
The treatment means of radical cure.For serious diabetic, it usually needs take intensive insulin therapy.Since intensive treatment needs
Will even more multiple insulin injection 3 times a day, considerably increase the possibility that the risk that hypoglycemia occurs and weight rise.
Implantable insulin pump in research and development in recent years or clinical test is conducive to continue, smoothly controls blood glucose, and subtracts
The relevant complication of few diabetes.However, implantable insulin pump needs lasting as a kind of electronic equipment of et al. Ke
Electric energy is supplied.And the power-on time of existing minicell is generally shorter, once the energy content of battery is exhausted after implantation, it is necessary to again
Battery is replaced in operation.This can both cause painful and psychological frightened and anxiety physiologically to patient, can also increase patient
And its financial burden of family.
In inside of human body, the flowing of the contractile motion and blood of heart, which all has, stablizes and continual kinetic energy.If energy
Enough acquisitions wherein sub-fraction kinetic energy is simultaneously converted into electric energy, will be expected to become the ideal capacity source of implantable insulin pump.So
And since heart is human body " engine ", inappropriate acquisition heart kinetic energy will necessarily influence the function of heart, even result in
Heart injury.In addition, traditional induction generator volume based on Faraday's law is larger, complicated, be not suitable for
Et al. Ke.
Invention content
To solve the above problems, the present invention provides a kind of implanted self energizing insulin pump, which is characterized in that including blood glucose
Monitoring portion, the syringe pump of insulin injection, infusion catheter, control unit and Power Generation Section.Power Generation Section includes power generation main body, defeated
Go out unit, energy storage unit, fixed cell and encapsulated layer.Wherein, power generation main body is multi-layer film structure, including is located at hair
The piezoelectric material layer of electric main center, and the electrode layer positioned at piezoelectric material layer both sides, the power generation main body is by being attached at
Heart surface is to acquire cardiac energy for producing electricl energy.Output unit is connected with electrode layer, for generating power generation main body
Electric current export to energy storage unit.Energy storage unit is for storing electric energy and being blood sugar monitoring portion, syringe pump and letter
The power supply of number emission part.Fixed cell is located at the edge of power generation main body, for power generation main body to be fixed on the external membrane of heart.Encapsulated layer covers
In the surface of power generation main body, output unit, energy storage unit and fixed cell.
In addition, in the implanted self energizing insulin pump of the present invention, can also have the feature that：Wherein, it generates electricity
The shape of main body is quadrangle, and fixed cell is located at the centre of two narrow sides of quadrangle.
In addition, in the implanted self energizing insulin pump of the present invention, can also have the feature that：Wherein, it generates electricity
The shape of main body is triangle, and fixed cell is located at three vertex of triangle.
In addition, in the implanted self energizing insulin pump of the present invention, can also have the feature that：Wherein, it generates electricity
The shape of main body is oblong.
In addition, in the implanted self energizing insulin pump of the present invention, can also have the feature that：Wherein, piezoelectricity
Material layer contains nanoscale piezoelectric material, and nanoscale piezoelectric material is in piezo-electric crystal, piezoelectric ceramics and organic piezopolymer
Any one.
In addition, in the implanted self energizing insulin pump of the present invention, can also have the feature that：Wherein, piezoelectricity
Crystal is at least one layer of zinc oxide nano-wire array.
In addition, in the implanted self energizing insulin pump of the present invention, can also have the feature that：Wherein, piezoelectricity
Crystal, piezoelectric ceramics, organic piezopolymer can be the single or multi-layer structure of nanoscale piezoelectric material.
In addition, in the implanted self energizing insulin pump of the present invention, can also have the feature that：Wherein, it exports
Unit has output electrode and current rectifying and wave filtering circuit.
In addition, in the implanted self energizing insulin pump of the present invention, can also have the feature that：Wherein, it encapsulates
Layer is using the flexible macromolecule insulating materials of good biocompatibility as encapsulating material.
The effect of invention
Implanted self energizing insulin pump according to the present invention, since power generation main body is attached directly to heart surface,
Effectively nanoscale piezoelectric material can be made to deform upon the contraction of heart and diastole, to be converted into electric energy.As long as therefore
Heartbeat, the present invention using the biological energy source of patient itself provide electric energy, eliminate using battery as power supply must
It wants, needs operation to replace battery after solving the problems, such as energy content of battery exhaustion.
In addition, electricity generation system is fixed on the external membrane of heart, a side by the power generation main body due to the present invention using the fixed mode of point
Face can effectively acquire the energy of heart movement generation, on the other hand will not be generated to the contraction and diastole campaign of heart bright
Aobvious influence.
It, not only can be effectively by internal biological energy source since the present invention uses nanoscale piezoelectric material as power generation main body
It is converted into electric energy, and volume is small, is more suitable for et al. Ke.
Further, since the present invention is encapsulated using the flexible macromolecule insulating materials of good biocompatibility, therefore can will send out
Electric main body is isolated with vivo environment, can also effectively conduct the heart-shaped pressure generated that becomes to piezoelectric material.
Also, it since the power generation main body of the present invention is located at heart exterior, is not in direct contact with blood, because thrombus may be not present
Formation and apoplexy（Myocardial infarction or cerebral infarction）Risk.
Description of the drawings
Fig. 1 is that the power generation main body of the implanted self energizing insulin pump of the embodiment of the present invention one is the schematic diagram of quadrangle；
Fig. 2 is the partial cross-sectional view of the power generation main body of the implanted self energizing insulin pump of the embodiment of the present invention one；
Fig. 3 is that the power generation main body of the implanted self energizing insulin pump of the embodiment of the present invention two is the schematic diagram of triangle；
Fig. 4 is that the power generation main body of variation of the present invention is the schematic diagram of oblong；And
Fig. 5 is the circuit diagram of the embodiment of the present invention.
Specific implementation mode
Illustrate the specific implementation mode of implanted self energizing insulin pump of the present invention below in conjunction with attached drawing,
<Embodiment one>
Fig. 1 is that the power generation main body of implanted self energizing insulin pump in embodiment 1 is the schematic diagram of quadrangle, such as Fig. 1 institutes
Show, implanted self energizing insulin pump 20 has Power Generation Section 200, includes for monitoring the monitoring portion 173 of blood glucose, being used for human body
The syringe pump 17 of interior insulin injection, the infusion catheter 171 being connect with syringe pump, for signal to be radioed to external connect
Signal emission part 172, the signal receiving part for receiving signal of receiving apparatus（It is not shown in figure）And above each section of control
Control unit 18.Wherein, Power Generation Section 200 include power generation main body 21, output unit, energy storage unit 16, fixed cell 22 with
And encapsulated layer.Power generation main body 21 is rectangle, and respectively there are one fixed cells 22 for tool in two narrow sides of rectangle, for the master that will generate electricity
Body 21 is fixed on along systaltic direction on the external membrane of heart with long axis direction.When being implanted into power generation main body, pass through surgical operation
Mode manifests heart, and power generation main body is arranged along systaltic direction and fixed part is sewn on the external membrane of heart so that
Power generation main body fits with the external membrane of heart, and power generation main body can generate deformation with the bounce of heart at this time.
Fixed cell 22 is formed after being extended by encapsulated layer, and the inside of fixed cell 22 does not have electrode or piezoelectric material etc.
Electrification structure, therefore the electrification structure of power generation main body 21 will not be destroyed when being fixed using suture.Power generation main body 21 is in addition to solid
Order member 22 rest part and is not fixed except fixing, in favor of enable during heart contraction power generation main body 21 more
Good deforms upon.Since power generation main body uses rectangle, and installation direction is consistent with systaltic direction, therefore can be with
The mechanical energy that acquisition heart contraction generates well.
Output electrode 14 is for exporting the electric energy that power generation main body 21 generates to energy storage unit 16, in power storage list
Also there is current rectifying and wave filtering circuit 15, the electric current for being exported to output electrode 14 carries out rectifying and wave-filtering before member 16.Power storage
Portion 18 and the power supply of implanted self energizing insulin pump 17 and signal emission part 172 in order to control of unit 16.When blood sugar monitoring portion 173
When experiencing internal blood glucose value higher than threshold value, it is defeated into blood by infusion catheter 171 that control unit 18 can control syringe pump 17
Enter suitable insulin, meanwhile, signal emission part 172 can be by the work of internal blood glucose information and implanted self energizing insulin pump
Make state output to being positioned over external signal receiving part（It is not shown in figure）It is shown and is recorded.
Fig. 2 is the sectional view of the power generation main body part of the implanted self energizing insulin pump of the embodiment of the present invention, such as Fig. 2 institutes
Show, power generation main body 21 is multi-layer film structure, its central core is piezoelectric material layer 31, and piezoelectric material layer 31 is by ZnO nano-wire
Array forms, and the both sides of piezoelectric material layer 31 are respectively electrode layer 32 and electrode layer 33, electrode layer 32 and electrode layer 33 respectively with
Output electrode 14 is connected（It is not shown in figure）.Encapsulated layer 34 is located at the outside of electrode layer 32 and electrode layer 33, and encapsulated layer 34 has
There are good insulating properties and biocompatibility.
Fig. 5 is the circuit diagram of the embodiment of the present invention, as shown in figure 5, power generation main body 21 is connected with current rectifying and wave filtering circuit 15,
The electric energy that power generation main body 21 generates charges to energy storage unit 16 after current rectifying and wave filtering circuit 15, energy storage unit
16 for monitoring portion, syringe pump and the signal emission part in electrical appliance, that is, the present embodiment for powering.
<Embodiment two>
Fig. 3 is that the Power Generation Section of the embodiment of the present invention is the implanted self energizing insulin pump schematic diagram of triangle, such as Fig. 3 institutes
Show, the power generation main body 12 of implanted self energizing insulin pump 11 of the invention is triangle, and each vertex position of triangle is equal
There are one fixed cell 13, output electrode 14 and electrode layers for tool（See Fig. 2）It is connected, current rectifying and wave filtering circuit 15 and output electrode 14
It is connected, energy storage unit 16 is connected to the electric energy for storing the generation of power generation main body 12 after current rectifying and wave filtering circuit 15.
The shape of power generation main body 12 is triangle, when being installed on the external membrane of heart, is pushed up using positioned at Atria
Power generation main body 12 is fixed on the external membrane of heart by the fixed cell 13 on point.Wherein, the apex of the heart is directed toward on a vertex of triangle, remaining
The line on two vertex is parallel with systaltic direction.And each side of the triangle of power generation main body 12 and be not fixed, in this way
Both without limitation on the contraction of heart and diastole, piezoelectric material layer is additionally aided as the movement of heart deforms upon to generate electricity
Energy.
The advantages of power generation main body 12 is fabricated to triangle be more acquire the energy of heartbeat, this is because
Not only there are lateral contraction and diastole during heartbeat, also there is longitudinal contraction and diastole, when using triangle
When shape, a vertex of triangle is set as the direction towards the apex of the heart, and other two vertex is set as laterally receiving with heart
The direction of contracting is parallel, and whether heart cross-direction shrinkage is longitudinal contraction in this way, and power generation main body 12 can be driven to deform.Therefore
The shape of triangle can more utilize the energy that heartbeat generates than the shape of quadrangle.
Fixed cell 13 is extended in corresponding position by encapsulated layer and is formed, and the inside of fixed cell 13 does not contain piezoresistive material
Material and electrode material, therefore can be to avoid damage piezoelectric material layer and electrode layer in suture.
<Variation>
This variation is compared with embodiment one, and other than the shape of power generation main body is oblong, others setting is homogeneous
Together.As shown in figure 4, the shape of power generation main body 42 is oblong, there is fixed cell 41, power generation in two apexes of oblong
The advantages of shape of main body 42 is oblong is not sharp corner, contributes to the probability for reducing impair cardiac.
Certainly, the shape of the power generation main body of implanted self energizing insulin pump of the invention can be various shapes, not only
Triangle, quadrangle and the oblong being limited in above-mentioned two embodiment.
Claims (9)
1. a kind of implanted self energizing insulin pump, which is characterized in that including：
Blood sugar monitoring portion；
The syringe pump of insulin injection；
The infusion catheter being connect with syringe pump；
Signal emission part for signal to be radioed to external reception device；
Signal receiving part for receiving signal；
Control unit；And
For the blood sugar monitoring portion, the syringe pump power Power Generation Section,
Wherein, the Power Generation Section includes power generation main body, output unit, energy storage unit, fixed cell and encapsulated layer,
The power generation main body is multi-layer film structure, includes the piezoelectric material layer positioned at the power generation main body center, and be located at
The electrode layer of piezoelectric material layer both sides, the power generation main body are attached directly to heart surface to acquire cardiac energy for generating electricity
Can,
The output unit is connected with the electrode layer, and the electric current for generating power generation main body is exported to the power storage
Unit,
The energy storage unit is for storing electric energy and emitting for the blood sugar monitoring portion, the syringe pump and the signal
Portion powers,
The fixed cell is located at the edge of the power generation main body, is pasted for fixing power generation main body along systaltic direction
Together in the external membrane of heart,
The encapsulated layer is covered in the power generation main body, the output unit, the energy storage unit and the fixed list
The surface of member.
2. implanted self energizing insulin pump as described in claim 1, it is characterised in that：
Wherein, the shape of the power generation main body is quadrangle, and the centre that the fixed cell is located at two narrow sides of quadrangle makes
The power generation main body is fixed along the systaltic direction with long axis direction and fits in the external membrane of heart.
3. implanted self energizing insulin pump as described in claim 1, it is characterised in that：
Wherein, the shape of the power generation main body is triangle, and three vertex that the fixed cell is located at triangle make the hair
Two vertex of electric main body fit in the external membrane of heart parallelly with the direction of heart cross-direction shrinkage.
4. implanted self energizing insulin pump as described in claim 1, it is characterised in that：
Wherein, the shape of the power generation main body be oblong, the fixed cell be located at the oblong two vertex make described in
Power generation main body is fixed along the systaltic direction with long axis direction and fits in the external membrane of heart.
5. implanted self energizing insulin pump as described in claim 1, it is characterised in that：
Wherein, the piezoelectric material layer contains nanoscale piezoelectric material, and the nanoscale piezoelectric material is piezo-electric crystal, piezoelectricity pottery
Any one in porcelain and organic piezopolymer.
6. implanted self energizing insulin pump as claimed in claim 5, it is characterised in that：
Wherein, the piezo-electric crystal is at least one layer of zinc oxide nano-wire array.
7. implanted self energizing insulin pump as claimed in claim 5, it is characterised in that：
Wherein, the piezo-electric crystal, piezoelectric ceramics, organic piezopolymer can be the single-layer or multi-layer of nanoscale piezoelectric material
Structure.
8. implanted self energizing insulin pump as described in claim 1, it is characterised in that：
Wherein, output unit has output electrode and current rectifying and wave filtering circuit.
9. implanted self energizing insulin pump as described in claim 1, it is characterised in that：
Wherein, the encapsulated layer is using the flexible macromolecule insulating materials of good biocompatibility as encapsulating material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310733133.5A CN104740714B (en) | 2013-12-26 | 2013-12-26 | Implanted self energizing insulin pump |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310733133.5A CN104740714B (en) | 2013-12-26 | 2013-12-26 | Implanted self energizing insulin pump |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104740714A CN104740714A (en) | 2015-07-01 |
| CN104740714B true CN104740714B (en) | 2018-08-28 |
Family
ID=53581320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310733133.5A Expired - Fee Related CN104740714B (en) | 2013-12-26 | 2013-12-26 | Implanted self energizing insulin pump |
Country Status (1)
| Country | Link |
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| CN (1) | CN104740714B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10898647B2 (en) | 2015-07-31 | 2021-01-26 | Sanofi-Aventis Deutschland Gmbh | Sensor, cartridge and drug delivery device |
| DK3328465T3 (en) | 2015-07-31 | 2020-06-15 | Sanofi Aventis Deutschland | SENSOR FOR A PHARMACEUTICAL DELIVERY DEVICE |
| JP6862417B2 (en) | 2015-07-31 | 2021-04-21 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Sensors, cartridges, and drug delivery devices |
| CN107847678A (en) | 2015-07-31 | 2018-03-27 | 赛诺菲-安万特德国有限公司 | Sensor, cartridge case and delivery device |
| FR3059553B1 (en) * | 2016-12-07 | 2021-04-23 | Univ Grenoble Alpes | IMPLANTABLE DEVICE |
| CN108310477B (en) * | 2018-01-24 | 2020-12-11 | 山东百多安医疗器械股份有限公司 | Rechargeable implanted automatic voltage regulation and distribution system with program control function |
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|---|---|---|---|---|
| CN102202563A (en) * | 2008-09-23 | 2011-09-28 | 因库博实验室有限责任公司 | Energy harvesting-mechanism for medical devices |
| CN203989258U (en) * | 2013-12-26 | 2014-12-10 | 中国人民解放军第二军医大学 | Implanted self energizing insulin pump |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7729768B2 (en) * | 2005-03-25 | 2010-06-01 | Proteus Biomedical, Inc. | Implantable cardiac motion powered piezoelectric energy source |
| JP2010273408A (en) * | 2009-05-19 | 2010-12-02 | Emprie Technology Development LLC | Power device, method of generating power, and method of manufacturing the power device |
| KR101336196B1 (en) * | 2011-08-18 | 2013-12-05 | 한국과학기술원 | Bio-Nanogenerator and manufacturing method for the same |
| EP2639845B1 (en) * | 2012-03-12 | 2014-11-19 | Sorin CRM SAS | Autonomous intracorporeal capsule with piezoelectric energy recovery |
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2013
- 2013-12-26 CN CN201310733133.5A patent/CN104740714B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102202563A (en) * | 2008-09-23 | 2011-09-28 | 因库博实验室有限责任公司 | Energy harvesting-mechanism for medical devices |
| CN203989258U (en) * | 2013-12-26 | 2014-12-10 | 中国人民解放军第二军医大学 | Implanted self energizing insulin pump |
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| CN104740714A (en) | 2015-07-01 |
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