CN104740762B - Self energizing brain pacemaker - Google Patents

Self energizing brain pacemaker Download PDF

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Publication number
CN104740762B
CN104740762B CN201310731416.6A CN201310731416A CN104740762B CN 104740762 B CN104740762 B CN 104740762B CN 201310731416 A CN201310731416 A CN 201310731416A CN 104740762 B CN104740762 B CN 104740762B
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CN
China
Prior art keywords
main body
generating main
self energizing
heart
brain pacemaker
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Expired - Fee Related
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CN201310731416.6A
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Chinese (zh)
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CN104740762A (en
Inventor
张�浩
曲丹
郎希龙
徐志云
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Second Military Medical University SMMU
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Second Military Medical University SMMU
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Abstract

The present invention provides a kind of self energizing brain pacemaker, it is characterised in that including impulse generator, stimulating electrode and Power Generation Section.Power Generation Section includes generating main body, output unit, energy storage unit, fixed cell and encapsulated layer.Wherein, generating main body is multi-layer film structure, including positioned at the piezoelectric material layer of generating main center, and the electrode layer positioned at piezoelectric material layer both sides, and generating main body is used to produce electric energy by being attached at heart surface to gather cardiac energy.Output unit is connected with electrode layer, and the electric current for generating main body to be produced is exported to energy storage unit.Energy storage unit is used to store electric energy and power for impulse generator.Fixed cell is located at the edge of generating main body, for generating main body to be fixed on into the external membrane of heart.Encapsulated layer is covered in the surface of generating main body, output unit, energy storage unit and fixed cell.The self energizing brain pacemaker of the present invention need not change battery, can use all the life.

Description

Self energizing brain pacemaker
Technical field
The present invention relates to a kind of self energizing brain pacemaker, belong to medical instruments field.
Background technology
As the mankind deepen continuously to the understanding of various diseases, increasing disease can use implanted electronics Device is diagnosed or treated.
Wherein, implantation brain pacemaker can by controlled in Stimulation of The Brain motion related neural, suppression cause Parkinsonian symptoms Abnormal signal, alleviate and even eliminate the symptoms such as the trembling of patient, stiff and slow movement, its is recovered original movable energy Power and self-care ability.But, the battery of brain pacemaker is 5~8 years, and electricity must pass through surgical operation after exhausting Mode changes the battery of brain pacemaker.This can both cause painful and psychological frightened and anxiety physiologically to patient, also The financial burden of patient and its family can be increased.
The content of the invention
To solve the above problems, the present invention provides a kind of self energizing brain pacemaker, it is characterised in that including pulse generation Device, stimulating electrode and Power Generation Section.Power Generation Section includes generating main body, output unit, energy storage unit, fixed cell and envelope Fill layer.Wherein, generating main body is multi-layer film structure, including positioned at the piezoelectric material layer of generating main center, and positioned at pressure The electrode layer of material layer both sides, generating main body is used to produce electric energy by being attached at heart surface to gather cardiac energy.It is defeated Go out unit with electrode layer to be connected, the electric current for generating main body to be produced is exported to energy storage unit.Energy storage unit For storing electric energy and being powered for impulse generator.Fixed cell is located at the edge of generating main body, for generating main body to be fixed In the external membrane of heart.Encapsulated layer is covered in the surface of generating main body, output unit, energy storage unit and fixed cell.
In addition, in the self energizing brain pacemaker of the present invention, can also have the feature that:Wherein, generating main body Quadrangle is shaped as, fixed cell is located at the centre on two narrow sides of quadrangle.
In addition, in the self energizing brain pacemaker of the present invention, can also have the feature that:Wherein, generating main body Triangle is shaped as, fixed cell is located at three summits of triangle.
In addition, in the self energizing brain pacemaker of the present invention, can also have the feature that:Wherein, generating main body It is shaped as Long Circle.
In addition, in the self energizing brain pacemaker of the present invention, can also have the feature that:Wherein, piezoelectric material layer Containing nanoscale piezoelectric, nanoscale piezoelectric is any in piezo-electric crystal, piezoelectric ceramics and organic piezopolymer It is a kind of.
In addition, in the self energizing brain pacemaker of the present invention, can also have the feature that:Wherein, piezo-electric crystal is At least one layer of zinc oxide nano-wire array.
In addition, in the self energizing brain pacemaker of the present invention, can also have the feature that:Wherein, piezo-electric crystal, pressure Electroceramics, organic piezopolymer can be the single or multiple lift structure of nanoscale piezoelectric.
In addition, in the self energizing brain pacemaker of the present invention, can also have the feature that:Wherein, output unit has There are output electrode and current rectifying and wave filtering circuit.
In addition, in the self energizing brain pacemaker of the present invention, can also have the feature that:Wherein, encapsulated layer is with life The good flexible macromolecule insulating materials of thing compatibility is used as encapsulating material.
The effect of invention and effect
According to the self energizing brain pacemaker of the present invention, because generating main body is attached directly to heart surface, therefore, it is possible to have The contraction by heart of effect deforms upon nanoscale piezoelectric with diastole, so as to be converted into electric energy.As long as therefore heart is jumped Dynamic, the present invention provides electric energy using the biological energy source of patient itself, eliminates the necessity for using battery as power supply, solves The energy content of battery needs the problem of battery is changed in operation after exhausting.
Further, since electricity generation system is fixed on the external membrane of heart, a side by the generating main body of the present invention by the way of point is fixed Face can effectively gather the energy of heart movement generation, on the other hand also the contraction and diastole campaign of heart will not be produced bright Aobvious influence.
, not only can be effectively by internal biological energy source due to the present invention using nanoscale piezoelectric as generating main body Electric energy is converted into, and volume is small, is more suitable for et al. Ke.
Further, since the present invention is encapsulated using the flexible macromolecule insulating materials of good biocompatibility, therefore it will can send out Electric main body is isolated with vivo environment, can also effectively conduct the heart-shaped pressure for becoming generation to piezoelectric.
Also, because the generating main body of the present invention is located at heart exterior, do not contacted directly with blood, thus in the absence of thrombus Formed and apoplexy(Miocardial infarction or cerebral infarction)Risk.
Brief description of the drawings
Fig. 1 is that the generating main body of the self energizing brain pacemaker of the embodiment of the present invention one is the schematic diagram of quadrangle;
Fig. 2 is the partial section of the generating main body of the self energizing brain pacemaker of the embodiment of the present invention one;
Fig. 3 is that the generating main body of the self energizing brain pacemaker of the embodiment of the present invention two is the schematic diagram of triangle;
Fig. 4 is that the generating main body of variation of the present invention is the schematic diagram of Long Circle;And
Fig. 5 is the circuit diagram of the embodiment of the present invention one.
Embodiment
Illustrate the embodiment of self energizing brain pacemaker of the present invention below in conjunction with accompanying drawing,
<Embodiment one>
Fig. 1 is that the generating main body of self energizing brain pacemaker in embodiment 1 is the schematic diagram of quadrangle, as shown in figure 1, confession Energy brain pacemaker 20 has Power Generation Section 200, impulse generator 17 and stimulating electrode 18.Wherein, Power Generation Section 200 includes generating main body 21, output unit, energy storage unit 16, fixed cell 22 and encapsulated layer.Generating main body 21 is rectangle, at two of rectangle Respectively there is a fixed cell 22, for generating main body 11 to be fixed on long axis direction along systaltic direction on narrow side On the external membrane of heart.When being implanted into generating main body, heart is manifested by way of surgical operation, by generating main body along systaltic Direction, which is set, is simultaneously sewn to fixed part on the external membrane of heart so that generating main body fits with the external membrane of heart, and now generating main body can be with The bounce for heart produces deformation.
Fixed cell 22 is made up of encapsulated layer, and the inside of fixed cell 22 does not have the generating knot such as electrode or piezoelectric Structure, therefore the electrification structure of generating main body 21 will not be destroyed when being fixed using suture.Because generating main body employs rectangle, and And installation direction is consistent with systaltic direction, therefore it can be very good to gather the mechanical energy that heart contraction is produced.
The remainder in addition to being fixed with fixed cell 22 of generating main body 21 is not fixed, in favor of systaltic During generating main body 21 is preferably deformed upon.Output unit has output electrode 14 and current rectifying and wave filtering circuit 15, the electric energy that output electrode 14 is used to produce generating main body 21 is exported to energy storage unit 16, in energy storage unit 16 Also there is current rectifying and wave filtering circuit 15 before, the electric current for being exported to output electrode 14 carries out rectifying and wave-filtering.Energy storage unit 16 are supplied to electric energy the impulse generator 17 of self energizing brain pacemaker.Stimulating electrode 18 is implanted into encephalic, and impulse generator 17 is produced Raw high frequency electric pulse stimulates brain to control the related neural of motion by stimulating electrode 18, suppresses to cause the exception of Parkinsonian symptoms Signal.
Fig. 2 is the sectional view of the generating main part of the self energizing brain pacemaker of the embodiment of the present invention, and generating main body 21 is Multi-layer film structure, as shown in Fig. 2 the central core of generating main body 21 is piezoelectric material layer 31, in the present embodiment, piezoelectric Layer 31 is made up of ZnO nanowire array, and the both sides of piezoelectric material layer 31 are respectively electrode layer 32 and electrode layer 33, the He of electrode layer 32 Electrode layer 33 is connected with output electrode 14 respectively(Do not shown in figure).Encapsulated layer 34 is located at the outer of electrode layer 32 and electrode layer 33 Side, encapsulated layer 34 has good insulating properties and biocompatibility.
Fig. 5 is the circuit diagram of the embodiment of the present invention, as shown in figure 5, generating main body 21 is connected with current rectifying and wave filtering circuit 15, The electric energy that generating main body 21 is produced charges after current rectifying and wave filtering circuit 15 to energy storage unit 16, energy storage unit 16 for being that the impulse generator in the present embodiment is powered for electrical appliance.
<Embodiment two>
Fig. 3 is that the Power Generation Section of the embodiment of the present invention is the self energizing brain pacemaker schematic diagram of triangle, as shown in figure 3, this The generating main body 12 of the self energizing brain pacemaker 11 of invention is triangle, and each vertex position of triangle is respectively provided with a fixation Unit 13, output electrode 14 and electrode layer(See Fig. 2)It is connected, current rectifying and wave filtering circuit 15 is connected with output electrode 14, electric energy Memory cell 16 is used to store the electric energy that Power Generation Section is produced after being connected to current rectifying and wave filtering circuit 15.
Fig. 2 is the sectional view of the self energizing brain pacemaker of the embodiment of the present invention, as shown in Fig. 2 the central core of generating main body For piezoelectric material layer 31, piezoelectric material layer 31 is made up of ZnO nanowire array, and the both sides of piezoelectric material layer 31 are respectively electrode layer 32 and electrode layer 33, electrode layer 32 and electrode layer 33 are connected with output electrode 14 respectively.Encapsulated layer 34 is located at electrode layer electrode The outside of layer 32 and electrode layer 33.The surface of actually whole self energizing brain pacemaker 11 is all covered with the envelope of one layer of good insulating Layer 34 is filled, macromolecule polymeric material can be used in encapsulated layer 34, and encapsulated layer 34 has good biocompatibility so that confession Energy brain pacemaker 11 will not cause rejection when implanting.
As shown in figure 3, generating main body 12 is shaped as triangle, when being installed on the external membrane of heart, using positioned at three Generating main body 12 is fixed on the external membrane of heart of myocardial wall by the fixed cell 13 on angular three summits.And the three of generating main body 12 Each angular side is not fixed, contraction and diastole so both without limitation on heart, additionally aids piezoelectric material layer with the heart Dirty motion deforms upon to produce electric energy.
The advantage that generating main body 12 makes triangularity is that can more gather the energy of heartbeat, because The not only contraction and diastole of transverse direction, also has longitudinal contraction and diastole, when using triangle during heartbeat During shape, a summit of triangle is set to the direction towards the apex of the heart, and two other summit is set to laterally receive with heart The direction of contracting is parallel, and so whether heart cross-direction shrinkage is longitudinal contraction, can drive generating main body 12 to deform.Therefore The shape of triangle can more utilize the energy of heartbeat generation than the shape of quadrangle.
Fixed cell 13 is extended by encapsulated layer and formed in corresponding position, and the inside of fixed cell 13 does not contain piezoresistive material Material and electrode material, therefore damage piezoelectric material layer and electrode layer in suture can be avoided.
Electric energy is supplied to the energy storage unit 16 of biological energy source self energizing brain pacemaker by electric energy by energy storage unit 16 It is supplied to the impulse generator 17 of self energizing brain pacemaker.Impulse generator 17 produces high frequency electric pulse and pierced by stimulating electrode 18 Swash the related neural of intracerebral control motion, suppress to cause the abnormal signal of Parkinsonian symptoms.
<Variation>
This variation compared with embodiment one, except generating main body be shaped as Long Circle in addition to, others set homogeneous Together.As shown in figure 4, generating main body 42 is shaped as Long Circle, in two apexes of Long Circle there is fixed cell 41, generate electricity The advantage for being shaped as Long Circle of main body 42 is, without sharp corner, to help to mitigate the damage to heart.
Certainly, the shape of the generating main body of self energizing brain pacemaker of the invention can be various shapes, be not limited only to State triangle, quadrangle and the Long Circle in two embodiments.

Claims (9)

1. a kind of self energizing brain pacemaker, it is characterised in that including:
Impulse generator for producing electro photoluminescence;
The stimulating electrode being connected with the impulse generator;And
The Power Generation Section powered for the impulse generator,
Wherein, the Power Generation Section includes generating main body, output unit, energy storage unit, fixed cell and encapsulated layer,
The generating main body is multi-layer film structure, including positioned at the piezoelectric material layer of the generating main center, and be located at The electrode layer of piezoelectric material layer both sides, the generating main body is attached directly to heart surface to be used to produce electricity to gather cardiac energy Can,
The output unit is connected with the electrode layer, and the electric current for generating main body to be produced is exported to the power storage Unit,
The energy storage unit is used to store electric energy and power for the impulse generator,
The fixed cell is located at the edge of the generating main body, for by generating main body with long axis direction along systaltic Direction is fixed on the external membrane of heart so that generating main body fits with the external membrane of heart,
The encapsulated layer is covered in the generating main body, the output unit, the energy storage unit and the fixed list The surface of member.
2. self energizing brain pacemaker as claimed in claim 1, it is characterised in that:
Wherein, the generating main body is shaped as quadrangle, and the centre that the fixed cell is located at two narrow sides of quadrangle makes The generating main body is fixed along the systaltic direction with long axis direction and fits in the external membrane of heart.
3. self energizing brain pacemaker as claimed in claim 1, it is characterised in that:
Wherein, the generating main body is shaped as triangle, and three summits that the fixed cell is located at triangle make the hair Two summits of electric main body fit in the external membrane of heart parallelly with the direction of heart cross-direction shrinkage.
4. self energizing brain pacemaker as claimed in claim 1, it is characterised in that:
Wherein, the generating main body is shaped as Long Circle, the fixed cell be located at the Long Circle two summits make it is described Generating main body is fixed along the systaltic direction with long axis direction and fits in the external membrane of heart.
5. self energizing brain pacemaker as claimed in claim 1, it is characterised in that:
Wherein, the piezoelectric material layer contains nanoscale piezoelectric, and the nanoscale piezoelectric is piezo-electric crystal, piezoelectricity pottery Any one in porcelain and organic piezopolymer.
6. self energizing brain pacemaker as claimed in claim 5, it is characterised in that:
Wherein, the piezo-electric crystal is at least one layer of zinc oxide nano-wire array.
7. self energizing brain pacemaker as claimed in claim 5, it is characterised in that:
Wherein, the piezo-electric crystal, piezoelectric ceramics, organic piezopolymer can be the single or multiple lift of nanoscale piezoelectric Structure.
8. self energizing brain pacemaker as claimed in claim 1, it is characterised in that:
Wherein, output unit has output electrode and current rectifying and wave filtering circuit.
9. self energizing brain pacemaker as claimed in claim 1, it is characterised in that:
Wherein, the flexible macromolecule insulating materials of the encapsulated layer using good biocompatibility is used as encapsulating material.
CN201310731416.6A 2013-12-26 2013-12-26 Self energizing brain pacemaker Expired - Fee Related CN104740762B (en)

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Publication number Priority date Publication date Assignee Title
US10463864B2 (en) * 2015-09-15 2019-11-05 The Regents Of The University Of Michigan Energy harvesting for leadless pacemakers
CN105233407B (en) * 2015-10-19 2017-11-21 徐醒忠 A kind of biological electro-therapeutic apparatus and its electrotherapeutic method

Citations (2)

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Publication number Priority date Publication date Assignee Title
CN101394807A (en) * 2005-12-12 2009-03-25 弗吉尼亚州立大学 Self-sensing stents, smart materials-based stents, drug delivery systems, other medical devices, and medical uses for piezo-electric materials
CN204073100U (en) * 2013-12-26 2015-01-07 中国人民解放军第二军医大学 Self energizing brain pacemaker

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7729768B2 (en) * 2005-03-25 2010-06-01 Proteus Biomedical, Inc. Implantable cardiac motion powered piezoelectric energy source
WO2010005915A2 (en) * 2008-07-06 2010-01-14 Synecor Llc Energy harvesting for implanted medical devices

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101394807A (en) * 2005-12-12 2009-03-25 弗吉尼亚州立大学 Self-sensing stents, smart materials-based stents, drug delivery systems, other medical devices, and medical uses for piezo-electric materials
CN204073100U (en) * 2013-12-26 2015-01-07 中国人民解放军第二军医大学 Self energizing brain pacemaker

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