CN104740713A - Implantable biological energy insulin pump - Google Patents
Implantable biological energy insulin pump Download PDFInfo
- Publication number
- CN104740713A CN104740713A CN201310731830.7A CN201310731830A CN104740713A CN 104740713 A CN104740713 A CN 104740713A CN 201310731830 A CN201310731830 A CN 201310731830A CN 104740713 A CN104740713 A CN 104740713A
- Authority
- CN
- China
- Prior art keywords
- energy
- main body
- insulin pump
- power generation
- generating main
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14212—Pumping with an aspiration and an expulsion action
- A61M5/14216—Reciprocating piston type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0272—Electro-active or magneto-active materials
- A61M2205/0294—Piezoelectric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/04—General characteristics of the apparatus implanted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/201—Glucose concentration
Abstract
The invention provides an implantable biological energy insulin pump. The implantable biological energy insulin pump comprises a blood glucose monitoring unit, an insulin infusion pump, an infusion catheter, a control unit, a signal transmitting unit, a vitro communicator and a power generation unit. The power generation unit comprises a power generation body, adjusting ends, an output electrode, an encapsulation layer and an electrical energy storage unit. The power generation body is used for collecting mechanical energy produced during aortectasia and converting the mechanical energy into electric energy. The power generation body is of a multilayer film structure and comprises a piezoelectric material layer arranged on the central layer as well as a first electrode layer and a second electrode layer which are arranged on both sides of the piezoelectric material layer. The encapsulation layer covers the surfaces of the power generation body, the adjusting ends, the output electrode and the electrical energy storage unit. The adjusting ends are arranged at both ends of the power generation body for adjusting the length of the power generation body. The output electrode is used for transport electrical energy to the electrical energy storage unit. The implantable biological energy insulin pump needs no battery replacement and can achieve lifetime use after implantation.
Description
Technical field
The present invention relates to a kind of implantable insulin pump, belong to medical instruments field.
Background technology
Diabetes are commonly encountered diseases and the frequently-occurring disease of middle-older patient, as a kind of lifelong participation disease, still lack the treatment means of thoroughly radical cure at present.For serious diabetics, usually need to take intensive insulin therapy.Because intensive treatment needs 3 even more insulin injections every day, considerably increase the probability that hypoglycemic risk and body weight rising occur.
Implantable insulin pump in research and development in recent years or clinical trial is conducive to continuing, controlling blood glucose stably, and reduces the relevant complication of diabetes.But implantable insulin pump, as a kind of electronic equipment of et al. Ke, needs the supply of electrical energy continued.And the power-on time of existing minicell is general shorter, once the energy content of battery is exhausted after implanting, just need replacing battery of again performing the operation.This both can cause physiological misery and psychological fear and anxiety to patient, also can increase the financial burden of patient and family thereof.
At inside of human body, the contractile motion of heart and the flowing of blood all have stable and continual kinetic energy.If wherein sub-fraction kinetic energy be converted into electric energy can be gathered, the ideal capacity source becoming implantable insulin pump will be expected to.But because heart is human body " electromotor ", inappropriate collection heart kinetic energy will inevitably affect the function of heart, even causes heart and injury.In addition, traditional induction electromotor volume based on Faraday's law is comparatively large, complex structure, is not suitable for et al. Ke.
Summary of the invention
For solving the problem, the invention provides the implantable insulin pump that the interior also indirect utilization heart biology of a kind of implantable can be powered, it is characterized in that, comprise blood sugar monitoring portion, control part that insulin infusion pump, infusion catheter, the described syringe pump of control run, signal emission part, for Received signal strength external communicator and the Power Generation Section of electric energy is provided.Wherein, Power Generation Section comprises generating main body, adjustable side, output electrode, energy storage unit and encapsulated layer.Wherein, generating main body is used for holding aorta, the mechanical energy produced during to gather aortectasia, and is converted into electric energy.Generating main body is multi-layer film structure, comprises the piezoelectric material layer being positioned at central core, and lays respectively at the first electrode layer and the second electrode lay of piezoelectric material layer both sides.Adjustable side is positioned at the two ends of generating main body, for regulating the length of generating main body.Output electrode is used for electric energy to flow to energy storage unit.Energy storage unit is used for storage of electrical energy and is that blood sugar monitoring portion, control part, insulin infusion pump and signal emission part are powered.Encapsulated layer is covered in the surface of generating main body, adjustable side, output electrode and energy storage unit.
In addition, implantating biological energy insulin pump of the present invention can also have such feature: wherein, piezoelectric material layer contains nanoscale piezoelectric, and nanoscale piezoelectric is any one in piezoquartz, piezoelectric ceramics and organic piezopolymer.
In addition, implantating biological energy insulin pump of the present invention can also have such feature: wherein, and piezoquartz, piezoelectric ceramics, organic piezopolymer can be the single or multiple lift structure of nanoscale piezoelectric.
In addition, implantating biological energy insulin pump of the present invention can also have such feature: wherein, and described power storage portion is miniature rechargeable battery or electric capacity.
In addition, implantating biological energy insulin pump of the present invention can also have such feature: also comprise, current rectifying and wave filtering circuit, be connected between energy storage unit and output electrode.
In addition, implantating biological energy insulin pump of the present invention can also have such feature: wherein, and the fixed form of adjustable side uses that surgical thread is sewed up, any one in titanium clamp pincers folder or binding agent bonding.
In addition, implantating biological energy insulin pump of the present invention can also have such feature: wherein, one end of adjustable side is single latch, the tip of this latch is level and smooth and towards the outside of generating main body, the other end of adjustable side is draw-in groove, the side, inside of draw-in groove has the teeth groove matched with latch, and opposite side is plane, and latch and draw-in groove fasten.
In addition, implantating biological energy insulin pump of the present invention can also have such feature: wherein, and described encapsulated layer is using the flexible macromolecule insulant of good biocompatibility as encapsulating material.
In addition, implantating biological energy insulin pump of the present invention can also have such feature: Power Generation Section is less than 140mmHg to aortal pressure.
Invention effect and effect
Implantating biological energy insulin pump of the present invention, the energy produced during by implanting nanoscale piezoelectric to gather aortectasia is also converted into electric energy, as its energy source.As long as therefore heartbeat, the present invention can utilize the bioenergy of patient self to provide electric energy, eliminates the necessity using battery as power supply, solves after the energy content of battery is exhausted and passes through the problem that battery is changed in operation.
Because the present invention adopts nanoscale piezoelectric as generating main body, not only effectively the bioenergy in body can be converted into electric energy, and volume is small, is more suitable for et al. Ke.
Aortal outer wall is paperwrapped in owing to present invention employs soft loop configuration, and can fixing quantity native system to aortal pressure, the mechanical energy produced when therefore both can gather aortectasia efficiently, fully, can not produce obviously impact to cardiac function again.
In addition, because the present invention adopts the flexible macromolecule insulant of good biocompatibility to encapsulate, therefore generating main body and internal milieu can be isolated, also the pressure that aorta wall deformation produces effectively can be conducted to piezoelectric.
In addition, the adjustable side adjustable generating main body at generating main body two ends is utilized to hold aortal tensity, thus the deformation degree of adjustable piezoelectric material and output electricity.Again owing to not containing piezoelectric and electrode layer in adjustable side, therefore use sutures or the clamping timing of titanium can not damage the structure of generating main body.
Further, because generating main body of the present invention is positioned at aorta outside, directly do not contact with blood, thus there is not the risk of thrombosis and apoplexy (myocardial infarction or cerebral infarction).
Accompanying drawing explanation
Fig. 1 is the schematic diagram of the implantating biological energy insulin pump of the embodiment of the present invention one;
Fig. 2 is the schematic diagram of the generating main body of the embodiment of the present invention one;
Fig. 3 is the internal structure profile of the generating main body of the embodiment of the present invention one;
Fig. 4 is the partial enlarged drawing in main body A region of generating electricity in Fig. 3;
Fig. 5 is that the main body that generates electricity in the embodiment of the present invention one is installed on Supraaortic sectional view;
Fig. 6 is that in the embodiment of the present invention four, adjustable side is the schematic diagram of reciprocal latch structure; And
Fig. 7 is circuit diagram of the present invention.
Detailed description of the invention
The detailed description of the invention of implantating biological energy insulin pump of the present invention is below described with reference to the accompanying drawings,
< embodiment one >
Fig. 1 is the schematic diagram of the implantating biological energy insulin pump of the embodiment of the present invention one.As shown in Figure 1, implantating biological energy insulin pump 100 comprises control part 19, signal emission part 16, syringe pump 15, infusion catheter 151, blood sugar monitoring portion 20 and Power Generation Section 200, and Power Generation Section 200 comprises generating main body 11, current rectifying and wave filtering circuit 12, output electrode 14 and power storage portion 13.
Generating main body 11 is resilient loop configuration, can be surrounded on aorta 18 around, and generating main body 11 inside has piezoelectric, and aortal deformation can be utilized to produce electric energy.Be connected to current rectifying and wave filtering circuit 12 after the output electrode 14 of generating main body 11, the electric energy that generating main body 11 is exported becomes stable.After energy storage unit 13 is connected to current rectifying and wave filtering circuit 12, for store electrical energy, and power for the blood sugar monitoring portion 20 of bioenergy insulin pump 100, control part 19, signal emission part 16 and syringe pump 15.
Fig. 2 is the schematic diagram of the generating main body of the embodiment of the present invention one.As shown in Figure 2, the original state of generating main body 11 is the shape of open loop, respectively has an adjustable side 23, need two adjustable sides to link together when being arranged on aorta outer wall at the two ends of loop configuration.Encapsulated layer 22 is coated with at the outer surface of generating main body 11 and adjustable side 23.Generating main body has two output electrodes 14, exports for the electric energy that generating main body 11 is produced.
Fig. 3 is the internal structure profile of the generating main body of the embodiment of the present invention, as shown in Figure 3, the inside of generating main body 11 is multi-layer film structure, comprises the nanoscale piezoelectric 111 being positioned at main center's layer, and lays respectively at the first electrode layer 112 and the second electrode lay 113 of piezoelectric both sides.Encapsulated layer 22 adopts the flexible macromolecule insulant with biocompatibility, is covered in the surface of generating main body 11 and output electrode 14, and extends to form each adjustable side 23, both sides to the outside of generating main body 11.
Fig. 4 is the partial enlarged drawing in main body A region of generating electricity in Fig. 3.As shown in Figure 4, nanoscale piezoelectric 111, first electrode layer 112 and the second electrode lay 113 that are positioned at generating main body 11 central core adopt the high layer material of the conductivity such as gold or silver to make, and are connected with nanoscale piezoelectric 111.
Generating main body 11 is bending circulus in its natural state, and its membrane structure has good elasticity, holds aorta therefore, it is possible to submissive.
When implanting in vivo, can generating main body 11 be implanted to around aorta by operating method and hold aorta.By adjustment adjustable side 23, generating main body 11 is fitted tightly, to gather the energy that aorta deformation produces with aortal outer wall again.
The workload of heart 17 may be increased aortal excessive compressing, therefore can to measure the main body 11 that generates electricity to aortal pressure, avoid it to exert an adverse impact to heart by interim placement force sensor between generating main body 11 and aorta wall.
Because the inside of adjustable side 23 is not containing piezoelectric material layer and electrode layer, therefore when using sutures or titanium folder is closed the both sides of adjustable side 23, can not cause damage to generating main body 11.
Fig. 5 is that the main body that generates electricity in the embodiment of the present invention is installed on Supraaortic sectional view.The work process of implantating biological energy insulin pump of the present invention is described below in conjunction with Fig. 1 and Fig. 5.
As shown in Figure 1 and Figure 5, the main body 11 that generates electricity is surrounded on aorta 18.When heart 17 shrinks, the impact of blood flow makes aorta 18 expand, as shown in Figure 5, aorta wall 45 can produce a pressure F to generating main body 11, make piezoelectric material layer 111 that deformation occur, thus form electric potential difference and generation current at its two ends, electric current conducts to output electrode 14 by the first electrode layer 112 and the second electrode lay 113, again by entering energy storage unit 13 after current rectifying and wave filtering circuit 12, electric energy energy memory element 13 is miniature rechargeable battery.Energy storage unit 13 again by supply of electrical energy to the blood sugar monitoring portion 20 of implantating biological energy insulin pump, control part 19, signal emission part 16 and syringe pump 15.When blood glucose sensor experiences blood glucose value in body higher than threshold value, control part 19 can control syringe pump 15 by infusion catheter 151 to the appropriate insulin of blood infusion, meanwhile, the duty of the blood glucose information in body and insulin pump can be exported to external communicator 152 by signal emission part 16.
Fig. 7 is the circuit diagram of the embodiment of implantating biological energy insulin pump of the present invention, as shown in Figure 7, generating main body 11 is connected with current rectifying and wave filtering circuit 12, the electric energy that generating main body 11 produces charges to energy storage unit 13 after current rectifying and wave filtering circuit 12, and energy storage unit 13 is for powering for the blood sugar monitoring portion in electrical appliance and the present embodiment, control part, signal emission part and syringe pump.
< embodiment two >
In the present embodiment, the blood sugar monitoring portion of implantating biological energy insulin pump, control part, signal emission part, syringe pump, the shape of generating main body and the setting of adjustable side are identical with embodiment one, difference part is in the present embodiment, and the piezoelectric material layer of generating main body adopts nanoscale piezoceramic material.
Another one difference part is, in the present embodiment, adjustable side 23 adopts titanium clamping fixed.While fixing, use micro pressure sensor to detect generating main body to the pressure of aorta outer wall, slowly tighten up latch, until this pressure reaches 120-140mmHg.
< embodiment three >
In the present embodiment, the blood sugar monitoring portion of bioenergy insulin pump, control part, signal emission part, syringe pump, the shape of generating main body and the setting of adjustable side are identical with embodiment one, difference part is in the present embodiment, the piezoelectric material layer of generating main body adopts piezopolymer, and adjustable side adopts the mode of binding agent bonding to be fixed.While fixing, use micro pressure sensor to detect generating main body to the pressure of aorta outer wall, slowly tighten up latch, until this pressure reaches 120-140mmHg.
< embodiment four >
In the present embodiment, the blood sugar monitoring portion of bioenergy insulin pump, control part, signal emission part, syringe pump, the shape of generating main body and the setting of adjustable side are identical with embodiment one, difference part is in the present embodiment, as shown in Figure 6, one end of adjustable side 61 is single latch, crown is level and smooth and towards the outside of generating main body, to prevent the tissues such as crown impair cardiac or aorta.The other end of adjustable side 61 is draw-in groove, and the side, inside of draw-in groove has the teeth groove matched with latch, and opposite side is plane.When aorta outer wall is fixed in Power Generation Section, slowly latch is inserted draw-in groove, use micro pressure sensor to detect generating main body to the pressure of aorta outer wall simultaneously, slowly tighten up latch, until this pressure reaches 120-140mmHg.
Certain implantating biological energy insulin pump of the present invention is not limited to the design described in above embodiment, and its piezoelectric material layer, electrode layer all can adopt various existing appropriate materials to make with encapsulated layer.
Claims (9)
1. an implantating biological energy insulin pump, is characterized in that, comprising:
Blood sugar monitoring portion;
Insulin infusion pump;
The infusion catheter be connected with syringe pump;
Control the control part that described syringe pump runs;
Signal emission part;
For the external communicator of Received signal strength; And
For the Power Generation Section that described blood sugar monitoring portion, syringe pump, control part and signal emission part are powered,
Wherein, described Power Generation Section comprises generating main body, adjustable side, output electrode, energy storage unit and encapsulated layer,
Described generating main body is used for holding aorta, the mechanical energy produced during to gather aortectasia, and is converted into electric energy,
Described generating main body is multi-layer film structure, comprises the piezoelectric material layer being positioned at central core, and lays respectively at the first electrode layer and the second electrode lay of described piezoelectric material layer both sides,
Described adjustable side is positioned at the two ends of described generating main body, for regulating the length of described generating main body,
Described output electrode is used for electric energy to flow to energy storage unit,
Described energy storage unit is used for storage of electrical energy and is that described blood sugar monitoring portion, described syringe pump, described signal emission part and described control part are powered,
Described encapsulated layer is covered in described generating main body, described adjustable side, described output electrode and described energy storage unit surface.
2. implantating biological energy insulin pump as claimed in claim 1, is characterized in that:
Wherein, described piezoelectric material layer contains nanoscale piezoelectric, and described nanoscale piezoelectric is any one in piezoquartz, piezoelectric ceramics and organic piezopolymer.
3. implantating biological energy insulin pump as claimed in claim 2, is characterized in that:
Wherein, described piezoquartz, piezoelectric ceramics, organic piezopolymer can be the single or multiple lift structure of nanoscale piezoelectric.
4. implantating biological energy insulin pump as claimed in claim 1, is characterized in that:
Wherein, described power storage portion is miniature rechargeable battery or electric capacity.
5. implantating biological energy insulin pump as claimed in claim 1, is characterized in that, also comprise:
Current rectifying and wave filtering circuit, is connected between described energy storage unit and described output electrode.
6. implantating biological energy insulin pump as claimed in claim 1, is characterized in that:
Wherein, the fixed form of described adjustable side uses any one in sutures, titanium folder and bonding.
7. implantating biological energy insulin pump as claimed in claim 1, is characterized in that:
Wherein, one end of described adjustable side is single latch, and the tip of this latch is level and smooth and towards the outside of generating main body, the other end of described adjustable side is draw-in groove, the side, inside of draw-in groove has the teeth groove matched with described latch, and opposite side is plane, and described latch and described draw-in groove fasten.
8. implantating biological energy insulin pump as claimed in claim 1, is characterized in that:
Wherein, described encapsulated layer is using the flexible macromolecule insulant of good biocompatibility as encapsulating material.
9. implantating biological energy insulin pump as claimed in claim 1, is characterized in that:
Described Power Generation Section is less than 140mmHg to aortal pressure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310731830.7A CN104740713A (en) | 2013-12-26 | 2013-12-26 | Implantable biological energy insulin pump |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310731830.7A CN104740713A (en) | 2013-12-26 | 2013-12-26 | Implantable biological energy insulin pump |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104740713A true CN104740713A (en) | 2015-07-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310731830.7A Pending CN104740713A (en) | 2013-12-26 | 2013-12-26 | Implantable biological energy insulin pump |
Country Status (1)
| Country | Link |
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| CN (1) | CN104740713A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108671370A (en) * | 2018-06-20 | 2018-10-19 | 南京林业大学 | The insulin closed loop controlled release mechanisms of biological fuel cell driving |
| WO2023236532A1 (en) * | 2022-06-08 | 2023-12-14 | 深圳清华大学研究院 | Micro power generation apparatus based on blood vessel pulsation, and implantable micro device |
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| US20020013545A1 (en) * | 1998-01-29 | 2002-01-31 | David Soltanpour | Synthetic muscle based diaphragm pump apparatuses |
| JP2002085556A (en) * | 2000-07-14 | 2002-03-26 | Nikkiso Co Ltd | Embedment type artificial pancreas device |
| US20080132881A1 (en) * | 2005-11-09 | 2008-06-05 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Injectable controlled release fluid delivery system |
| US20100295419A1 (en) * | 2009-05-19 | 2010-11-25 | Yasuhisa Fujii | Electric power device, electric power generation method, and production method of electric power device |
| US20100298720A1 (en) * | 2009-04-16 | 2010-11-25 | Potkay Joseph Allen | In Situ Energy Harvesting Systems for Implanted Medical Devices |
| CN102197304A (en) * | 2008-11-04 | 2011-09-21 | 松下电器产业株式会社 | Measurement device, insulin infusion device, measurement method, method for controlling insulin infusion device, and program |
| WO2012011132A1 (en) * | 2010-07-20 | 2012-01-26 | SCUOLA SUPERIORE Dl STUDI UNIVERSITARI E Dl PERFEZIONAMENTO SANT'ANNA | System for controlled administration of a substance from a human-body-implanted infusion device |
| CN203619989U (en) * | 2013-12-26 | 2014-06-04 | 中国人民解放军第二军医大学 | Implanted type bioenergy insulin pump |
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2013
- 2013-12-26 CN CN201310731830.7A patent/CN104740713A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020013545A1 (en) * | 1998-01-29 | 2002-01-31 | David Soltanpour | Synthetic muscle based diaphragm pump apparatuses |
| JP2002085556A (en) * | 2000-07-14 | 2002-03-26 | Nikkiso Co Ltd | Embedment type artificial pancreas device |
| US20080132881A1 (en) * | 2005-11-09 | 2008-06-05 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Injectable controlled release fluid delivery system |
| CN102197304A (en) * | 2008-11-04 | 2011-09-21 | 松下电器产业株式会社 | Measurement device, insulin infusion device, measurement method, method for controlling insulin infusion device, and program |
| US20100298720A1 (en) * | 2009-04-16 | 2010-11-25 | Potkay Joseph Allen | In Situ Energy Harvesting Systems for Implanted Medical Devices |
| US20100295419A1 (en) * | 2009-05-19 | 2010-11-25 | Yasuhisa Fujii | Electric power device, electric power generation method, and production method of electric power device |
| WO2012011132A1 (en) * | 2010-07-20 | 2012-01-26 | SCUOLA SUPERIORE Dl STUDI UNIVERSITARI E Dl PERFEZIONAMENTO SANT'ANNA | System for controlled administration of a substance from a human-body-implanted infusion device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108671370A (en) * | 2018-06-20 | 2018-10-19 | 南京林业大学 | The insulin closed loop controlled release mechanisms of biological fuel cell driving |
| WO2023236532A1 (en) * | 2022-06-08 | 2023-12-14 | 深圳清华大学研究院 | Micro power generation apparatus based on blood vessel pulsation, and implantable micro device |
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