CN104721705A - Capsule for treating osteoporosis and preparation method of capsule - Google Patents
Capsule for treating osteoporosis and preparation method of capsule Download PDFInfo
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- CN104721705A CN104721705A CN201510176959.5A CN201510176959A CN104721705A CN 104721705 A CN104721705 A CN 104721705A CN 201510176959 A CN201510176959 A CN 201510176959A CN 104721705 A CN104721705 A CN 104721705A
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Abstract
The invention discloses a capsule for treating osteoporosis. The capsule comprises 320g-360g of radix paeoniae alba, 200g-250g of salviae miltiorrhizae, 320g-360g of rhizoma cyperi, 200g-250g of radix aucklandiae, 200g-250g of folium artemisiae argyi, 200g-250g of fructus aurantii, 320g-360g of rhizoma pinelliae prepared with ginger, 320g-360g of parched szechwan chinaberry fruits, 200g-250g of amomum kravanh and 200g-250g of glycyrrhiza. The invention further discloses a preparation method of the capsule. The capsule prepared from the herbal medicines is good in medicine efficacy, long in storage time, high in stability and capable of reducing medicine bitterness and easing discomfort of patients due to medicine taking.
Description
Technical field
The present invention relates to the medicine preparing technical field of gynaecopathia, be specifically related to a kind of osteoporotic Chinese medicinal composition capsules agent preparation method.
Background technology
Osteoporosis and osteoporosis, be one group of osteopathia that many reasons causes, osseous tissue has normal calcification, and calcium salt and substrate are normal rates, and the metabolic osteopathy being reduced to feature with unit volume inner bone tissues amount becomes.In most osteoporosis, caused by the minimizing of osseous tissue increases mainly due to bone absorption.With skeleton pain, be easy to fracture for feature.
For this reason, need to research and develop a kind of medicine for the treatment of osteoporosis, facilitate patients, and there is better drug effect.
Summary of the invention
The object of this invention is to provide a kind of osteoporotic Chinese medicine composition, and this medicine is prepared into the method for capsule.
For reaching above-mentioned purpose, provide a kind of Chinese medicine composition in one embodiment of the present of invention, this Chinese medicine composition comprises:
Radix Paeoniae Alba 320g ~ 360g; Radix Salviae Miltiorrhizae 200g ~ 250g; Rhizoma Cyperi 320g ~ 360g; Radix Aucklandiae 200g ~ 250g;
Folium Artemisiae Argyi 200g ~ 250g; Fructus Aurantii 200g ~ 250g; Processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 320g ~ 360g;
Fructus Toosendan (parched) 320g ~ 360g; Fructus Amomi Rotundus 200g ~ 250g; Radix Glycyrrhizae 200g ~ 250g.
As the optimization of above-described embodiment, in one embodiment of the present of invention, this Chinese medicine composition comprises:
Radix Paeoniae Alba 345g; Radix Salviae Miltiorrhizae 228g; Rhizoma Cyperi 345g; Radix Aucklandiae 228g;
Folium Artemisiae Argyi 228g; Fructus Aurantii 228g; Processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 228g;
Fructus Toosendan (parched) 345g; Fructus Amomi Rotundus 228g; Radix Glycyrrhizae 228g.
Provide the capsule preparation method thereof of this medicine in an alternative embodiment of the invention, the method comprises the following steps:
Step one: get the Rhizoma Cyperi of formula ratio, Radix Salviae Miltiorrhizae, Folium Artemisiae Argyi, Fructus Aurantii, Fructus Amomi Rotundus, the Radix Aucklandiae, add suitable quantity of water, heating and refluxing extraction goes out volatile oil, and filtering medicinal liquid and medicinal residues for subsequent use; Obtain volatile oil, first filtrate and medicinal residues;
Step 2, the Radix Paeoniae Alba of the medicinal residues in step one and formula ratio, Fructus Toosendan (parched), the processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae, Radix Glycyrrhizae to be decocted with water, merging filtrate and first filtrate; And after filtrate is concentrated into paste, add ethanol and stir evenly, leave standstill rear filtration, filtrate adds calcium hydrogen phosphate 30g ~ 50g after being concentrated into paste, and mixing, pulverizes and sieves after drying under reduced pressure; Obtain extract powder;
Step 3, the beta-schardinger dextrin-of volatile oil weight 4 times ~ 6 times of weight will be added in the volatile oil in step one, add the hexadecanol of volatile oil 1 times ~ 2 times, add 3 times to 20% ethanol of beta-schardinger dextrin-; The rear also drying under reduced pressure of grinding, crushed after being dried is sieved; Obtain beta-schardinger dextrin-inclusion;
Step 4, merged by the beta-schardinger dextrin-inclusion of the extract powder of step 2 and step 3, after adding micropowder silica gel, mixing is sieved, in incapsulating.
As optimization of the present invention, can in step 2, adding ethanol to alcohol content is 80%, and time of repose is greater than 12 hours.
As optimization of the present invention, the method that pharmaceutical composition prepares capsule is:
Step one: get the Rhizoma Cyperi of formula ratio, Radix Salviae Miltiorrhizae, Folium Artemisiae Argyi, Fructus Aurantii, Fructus Amomi Rotundus, the Radix Aucklandiae, adds 5 times to the water of said medicine weight, and reflux extracts volatile oil in 5 hours, and filtering medicinal liquid and medicinal residues for subsequent use; Obtain volatile oil, first filtrate and medicinal residues;
Step 2, the Radix Paeoniae Alba of the medicinal residues in step one and formula ratio, Fructus Toosendan (parched), the processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae, Radix Glycyrrhizae are decocted with water three times, add the water of 10 times of weight at every turn, decoct 1 hour, gradation is filtered; Merging filtrate and first filtrate; And filtrate to be concentrated into relative density be after the paste of 1.15 ~ 1.20, add ethanol stir evenly, leave standstill after filter, it is after the paste of 1.30 ~ 1.40 that filtrate is concentrated into relative density; Add calcium hydrogen phosphate 30g ~ 50g, mixing, pulverizes and sieves after drying under reduced pressure; Obtain extract powder;
Step 3, the beta-schardinger dextrin-of volatile oil weight 4 times ~ 6 times of weight will be added in the volatile oil in step one, add the hexadecanol of volatile oil 1 times ~ 2 times, add 3 times to 20% ethanol of beta-schardinger dextrin-; To grind after 60 minutes and drying under reduced pressure, crushed after being dried crosses No. 3 sieves; Obtain beta-schardinger dextrin-inclusion;
Step 4, the beta-schardinger dextrin-inclusion of the extract powder of step 2 and step 3 to be merged, mixed No. 3 sieves after adding micropowder silica gel 4g, in incapsulating.
As optimization of the present invention, the temperature of drying under reduced pressure is 70 DEG C ~ 75 DEG C, and pressure is-0.08Mpa ~-0.09Mpa.
In sum, the present invention has the following advantages:
1, the present invention provide firstly one and treats osteoporotic Chinese medicine composition, and this pharmaceutical composition has good therapeutic effect;
2, pharmaceutical composition is made capsule by the present invention, can overcome the defect of granule mouthfeel difference;
3, add stabilizing agent hexadecanol in the present invention, make medicine have good stability, after long-time preservation, still there is good curative effect of medication and character.
Detailed description of the invention
Prescription 1:
Radix Paeoniae Alba 345g; Radix Salviae Miltiorrhizae 228g; Rhizoma Cyperi 345g; Radix Aucklandiae 228g;
Folium Artemisiae Argyi 228g; Fructus Aurantii 228g; Processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 228g;
Fructus Toosendan (parched) 345g; Fructus Amomi Rotundus 228g; Radix Glycyrrhizae 228g.
Beta-schardinger dextrin-6 times of volatile oil weight;
Calcium hydrogen phosphate 40g;
Micropowder silica gel 4g
Hexadecanol 1 times of volatile oil.
Prescription 2:
Radix Paeoniae Alba 320g; Radix Salviae Miltiorrhizae 200g; Rhizoma Cyperi 320g; Radix Aucklandiae 200g;
Folium Artemisiae Argyi 200g; Fructus Aurantii 200g; Processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 200g;
Fructus Toosendan (parched) 320g; Fructus Amomi Rotundus 200g; Radix Glycyrrhizae 200g.
Beta-schardinger dextrin-6 times of volatile oil weight;
Calcium hydrogen phosphate 40g;
Micropowder silica gel 4g
Hexadecanol 2 times of volatile oil.
Prescription 3:
Radix Paeoniae Alba 345g; Radix Salviae Miltiorrhizae 228g; Rhizoma Cyperi 345g; Radix Aucklandiae 228g;
Folium Artemisiae Argyi 228g; Fructus Aurantii 228g; Processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 228g;
Fructus Toosendan (parched) 345g; Fructus Amomi Rotundus 228g; Radix Glycyrrhizae 228g.
Beta-schardinger dextrin-6 times of volatile oil weight;
Calcium hydrogen phosphate 40g;
Micropowder silica gel 4g.
Prescription 4:
Radix Paeoniae Alba 320g; Radix Salviae Miltiorrhizae 200g; Rhizoma Cyperi 320g; Radix Aucklandiae 200g;
Folium Artemisiae Argyi 200g; Fructus Aurantii 200g; Processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 200g;
Fructus Toosendan (parched) 320g; Fructus Amomi Rotundus 200g; Radix Glycyrrhizae 200g.
Beta-schardinger dextrin-6 times of volatile oil weight;
Calcium hydrogen phosphate 40g;
Micropowder silica gel 4g.
Embodiment 1:
The Chinese medicine composition of prescription 1 and prescription 2 is made capsule by following steps
Step one: get the Rhizoma Cyperi of formula ratio, Radix Salviae Miltiorrhizae, Folium Artemisiae Argyi, Fructus Aurantii, Fructus Amomi Rotundus, the Radix Aucklandiae, adds 5 times to the water of said medicine weight, and reflux extracts volatile oil in 5 hours, and filtering medicinal liquid and medicinal residues for subsequent use; Obtain volatile oil, first filtrate and medicinal residues;
Step 2, the Radix Paeoniae Alba of the medicinal residues in step one and formula ratio, Fructus Toosendan (parched), the processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae, Radix Glycyrrhizae are decocted with water three times, add the water of 10 times of weight at every turn, decoct 1 hour, gradation is filtered; Merging filtrate and first filtrate; And relative density is after the paste of 1.15 ~ 1.20 under filtrate being concentrated into room temperature, adding ethanol to alcohol content is stir evenly after 80%, leave standstill after 16 hours and filter, and it is after the paste of 1.30 ~ 1.40 that filtrate is concentrated into relative density at 60 DEG C; Add calcium hydrogen phosphate 30g ~ 50g, mixing, pulverized No. 3 sieves after drying under reduced pressure; Obtain extract powder;
Step 3, the beta-schardinger dextrin-of volatile oil weight 4 times ~ 6 times of weight will be added in the volatile oil in step one, add the hexadecanol of volatile oil 1 times ~ 2 times, add 3 times to 20% ethanol of beta-schardinger dextrin-; To grind after 60 minutes and drying under reduced pressure, crushed after being dried crosses No. 3 sieves; Obtain beta-schardinger dextrin-inclusion;
Step 4, the beta-schardinger dextrin-inclusion of the extract powder of step 2 and step 3 to be merged, mixed No. 3 sieves after adding micropowder silica gel 4g, in incapsulating.
Embodiment 2:
The Chinese medicine composition of prescription 3 and prescription 4 is made capsule by following steps
Step one: get the Rhizoma Cyperi of formula ratio, Radix Salviae Miltiorrhizae, Folium Artemisiae Argyi, Fructus Aurantii, Fructus Amomi Rotundus, the Radix Aucklandiae, adds 5 times to the water of said medicine weight, and reflux extracts volatile oil in 5 hours, and filtering medicinal liquid and medicinal residues for subsequent use; Obtain volatile oil, first filtrate and medicinal residues;
Step 2, the Radix Paeoniae Alba of the medicinal residues in step one and formula ratio, Fructus Toosendan (parched), the processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae, Radix Glycyrrhizae are decocted with water three times, add the water of 10 times of weight at every turn, decoct 1 hour, gradation is filtered; Merging filtrate and first filtrate; And relative density is after the paste of 1.15 ~ 1.20 under filtrate being concentrated into room temperature, adding ethanol to alcohol content is stir evenly after 80%, leave standstill after 16 hours and filter, and it is after the paste of 1.30 ~ 1.40 that filtrate is concentrated into relative density at 60 DEG C; Add calcium hydrogen phosphate 30g ~ 50g, mixing, pulverized No. 3 sieves after drying under reduced pressure; Obtain extract powder;
Step 3, the beta-schardinger dextrin-of volatile oil weight 4 times ~ 6 times of weight will be added in the volatile oil in step one, add 3 times to 20% ethanol of beta-schardinger dextrin-; To grind after 60 minutes and drying under reduced pressure, crushed after being dried crosses No. 3 sieves; Obtain beta-schardinger dextrin-inclusion;
Step 4, the beta-schardinger dextrin-inclusion of the extract powder of step 2 and step 3 to be merged, mixed No. 3 sieves after adding micropowder silica gel 4g, in incapsulating.
Medicine stability accelerated test
Medicine is carried out accelerated test under the condition of temperature 50 C, relative humidity 75%, and detect every two months medicines to four kinds of prescriptions, test item comprises outward appearance, drug effect etc.Through checking, add in the prescription embodiment of hexadecanol, the extension of validity of Traditional Chinese medicine capsule thing 5 ~ 6 months, illustrates that the medicine stability in capsule is better, effective ingredient reduces slow.
Claims (7)
1. treat an osteoporosis capsule, it is characterized in that: comprising:
Radix Paeoniae Alba 320g ~ 360g; Radix Salviae Miltiorrhizae 200g ~ 250g; Rhizoma Cyperi 320g ~ 360g; Radix Aucklandiae 200g ~ 250g;
Folium Artemisiae Argyi 200g ~ 250g; Fructus Aurantii 200g ~ 250g; Processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 320g ~ 360g;
Fructus Toosendan (parched) 320g ~ 360g; Fructus Amomi Rotundus 200g ~ 250g; Radix Glycyrrhizae 200g ~ 250g;
2. the method for claim 1, is characterized in that: this Chinese medicine composition comprises:
Radix Paeoniae Alba 345g; Radix Salviae Miltiorrhizae 228g; Rhizoma Cyperi 345g; Radix Aucklandiae 228g;
Folium Artemisiae Argyi 228g; Fructus Aurantii 228g; Processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 228g;
Fructus Toosendan (parched) 345g; Fructus Amomi Rotundus 228g; Radix Glycyrrhizae 228g.
3. prepare the method for capsule described in claim 1 or 2, comprise the following steps:
Step one: get the Rhizoma Cyperi of formula ratio, Radix Salviae Miltiorrhizae, Folium Artemisiae Argyi, Fructus Aurantii, Fructus Amomi Rotundus, the Radix Aucklandiae, add suitable quantity of water, heating and refluxing extraction goes out volatile oil, and filtering medicinal liquid and medicinal residues for subsequent use; Obtain volatile oil, first filtrate and medicinal residues;
Step 2, the Radix Paeoniae Alba of the medicinal residues in step one and formula ratio, Fructus Toosendan (parched), the processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae, Radix Glycyrrhizae to be decocted with water, merging filtrate and first filtrate; And after filtrate is concentrated into paste, add ethanol and stir evenly, leave standstill rear filtration, filtrate adds calcium hydrogen phosphate 30g ~ 50g after being concentrated into paste, and mixing, pulverizes and sieves after drying under reduced pressure; Obtain extract powder;
Step 3, the beta-schardinger dextrin-of volatile oil weight 4 times ~ 6 times of weight will be added in the volatile oil in step one, add the hexadecanol of volatile oil 1 times ~ 2 times, add 3 times to 20% ethanol of beta-schardinger dextrin-; The rear also drying under reduced pressure of grinding, crushed after being dried is sieved; Obtain beta-schardinger dextrin-inclusion;
Step 4, merged by the beta-schardinger dextrin-inclusion of the extract powder of step 2 and step 3, after adding micropowder silica gel, mixing is sieved, in incapsulating.
4. method as claimed in claim 3, it is characterized in that: in step 2, the weight adding water is medicinal residues, the Radix Paeoniae Alba, Fructus Toosendan (parched), the processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae and Radix Glycyrrhizae 10 times of weight.
5. method as claimed in claim 3, it is characterized in that: in step 2, adding ethanol to alcohol content is 80%, and time of repose is greater than 12 hours.
6. method as claimed in claim 3, is characterized in that: the method preparing capsule is:
Step one: get the Rhizoma Cyperi of formula ratio, Radix Salviae Miltiorrhizae, Folium Artemisiae Argyi, Fructus Aurantii, Fructus Amomi Rotundus, the Radix Aucklandiae, adds 5 times to the water of said medicine weight, and reflux extracts volatile oil in 5 hours, and filtering medicinal liquid and medicinal residues for subsequent use; Obtain volatile oil, first filtrate and medicinal residues;
Step 2, the Radix Paeoniae Alba of the medicinal residues in step one and formula ratio, Fructus Toosendan (parched), the processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae, Radix Glycyrrhizae are decocted with water three times, add the water of 10 times of weight at every turn, decoct 1 hour, gradation is filtered; Merging filtrate and first filtrate; And filtrate to be concentrated into relative density be after the paste of 1.15 ~ 1.20, add ethanol stir evenly, leave standstill after filter, it is after the paste of 1.30 ~ 1.40 that filtrate is concentrated into relative density; Add calcium hydrogen phosphate 30g ~ 50g, mixing, pulverizes and sieves after drying under reduced pressure; Obtain extract powder;
Step 3, the beta-schardinger dextrin-of volatile oil weight 4 times ~ 6 times of weight will be added in the volatile oil in step one, add the hexadecanol of volatile oil 1 times ~ 2 times, add 3 times to 20% ethanol of beta-schardinger dextrin-; To grind after 60 minutes and drying under reduced pressure, crushed after being dried crosses No. 3 sieves; Obtain beta-schardinger dextrin-inclusion;
Step 4, the beta-schardinger dextrin-inclusion of the extract powder of step 2 and step 3 to be merged, mixed No. 3 sieves after adding micropowder silica gel 4g, in incapsulating.
7. method as claimed in claim 3, is characterized in that: the temperature of described drying under reduced pressure is 70 DEG C ~ 75 DEG C, and pressure is-0.08Mpa ~-0.09Mpa.
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| CN201510176959.5A CN104721705A (en) | 2015-04-15 | 2015-04-15 | Capsule for treating osteoporosis and preparation method of capsule |
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| CN201510176959.5A CN104721705A (en) | 2015-04-15 | 2015-04-15 | Capsule for treating osteoporosis and preparation method of capsule |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1692928A (en) * | 2005-03-31 | 2005-11-09 | 扬子江药业集团有限公司 | Medicine for treating premenstrual syndrome invansion of hyperactive liver-qi and its prepn. method |
| CN101181588A (en) * | 2007-11-23 | 2008-05-21 | 扬子江药业集团有限公司 | Application of jing-qian-ping particle in the preparation of medicament for curing climacteric syndrome |
| CN101513484A (en) * | 2009-03-17 | 2009-08-26 | 河北大学附属医院 | A medicament composition for preventing and treating osteoporosis and the preparation thereof |
-
2015
- 2015-04-15 CN CN201510176959.5A patent/CN104721705A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1692928A (en) * | 2005-03-31 | 2005-11-09 | 扬子江药业集团有限公司 | Medicine for treating premenstrual syndrome invansion of hyperactive liver-qi and its prepn. method |
| CN101181588A (en) * | 2007-11-23 | 2008-05-21 | 扬子江药业集团有限公司 | Application of jing-qian-ping particle in the preparation of medicament for curing climacteric syndrome |
| CN101513484A (en) * | 2009-03-17 | 2009-08-26 | 河北大学附属医院 | A medicament composition for preventing and treating osteoporosis and the preparation thereof |
Non-Patent Citations (3)
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| [英]罗（ROWE,R,C.）等: "《药物辅料手册》", 31 January 2005, 化学工业出版社 * |
| 曹德英: "《药物剂型与制剂设计》", 31 July 2009, 化学工业出版社 * |
| 朱月龙: "《心理健康全书》", 31 October 2005, 海潮出版社 * |
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Application publication date: 20150624 |
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