CN105560551A - Traditional Chinese medicine composition for treating hyperlipidemia diseases and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating hyperlipidemia diseases and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating hyperlipidemia diseases and a preparation method thereof, and belongs to the technical field of medicine and health products. The traditional Chinese medicine composition for treating hyperlipidemia diseases is prepared from, by weight, 10-30 parts of lucid ganoderma, 10-30 parts of astragalus membranaceus, 3-16 parts of suncured ginseng, 7-28 parts of herba epimedii, 3-16 parts of Schisandra chinensis, 10-30 parts of the roots of red-rooted salvia, 9-26 parts of prepared fleece flower roots, 1-15 parts of loranthus parasiticus and 124-273 parts of pseudo-ginseng. A traditional Chinese medicine preparation is formed by mixing the traditional Chinese medicine composition and pseudo-ginseng in a powder mode. The traditional Chinese medicine preparation has the effects of lowering blood fat and strengthening the heart, the lung, the liver and the spleen.
Description
Technical field
The present invention relates to Medicines and Health Product field, in particular to Chinese medicine composition being used for the treatment of hyperlipidaemic conditions and preparation method thereof.
Background technology
Along with people's living standard day by day improve and work, the increasing of life stress, the sufferer such as hyperlipidemia, hypertension number increases year by year, also causes some complication simultaneously, greatly have impact on daily life.Health-related medicine in the market, mainly based on health preserving, defying age, the less health-related medicine that can reduce human body blood fat function.
Summary of the invention
The first object of the present invention is to provide a kind of Chinese medicine composition being used for the treatment of hyperlipidaemic conditions, and strong liver spleen cardio-pulmonary function, can reduce human body blood fat.
The second object of the present invention is to provide a kind of above-mentioned manufacture method being used for the treatment of the Chinese medicine composition of hyperlipidaemic conditions.
In order to realize above-mentioned purpose of the present invention, spy by the following technical solutions:
Have a Chinese medicine composition for health care, be prepared from primarily of compositions A, described compositions A comprises following composition: by weight:
Ganoderma profile is umbrella, cap kidney shape, semicircle or subcircular, is the sporophore of On Polyporaceae Ganoderma.There is effect of invigorating QI and tranquilization, relieving cough and asthma, for dizzy sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.
Tragacanthin is hard and tough, not frangibility, and section fibrous is strong, and aobvious mealiness, skin zone's yellow-white, and woody part is faint yellow, has radial texture and crack, and Lao Gen center is even in dry and decayed shape, pitchy or in cavity.Feeble QI temperature, taste is micro-sweet, and that chews micro-ly has beany flavor.There is good disease-prevention health effect.
Radix Ginseng is formed through working procedure processing such as washing, Exposure to Sunlight, oven dry by the dry root welding technology of Araliaceae Radix Ginseng, form keeps the prototype of Radix Ginseng.Radix Ginseng adds active ingredient in man-hour and volatile oil content loss is less, and the property of medicine is gentleer.There is invigorating qi and benefiting blood, tranquilizing by nourishing the heart, regulate effect that is neural, cardiovascular system.
Herba Epimedii is the stem and leaf of the multiple Herba Epimedii such as Berberidaceae plant Herba Epimedii, Epimedium sagittatum, Epimedium wushanense, Herba Epimedii.Taste is returned through acrid, sweet, warm.Return liver, kidney channel cures mainly function: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.
Fructus Schisandrae Chinensis is the dry mature fruit of magnoliaceae schisandra, dries or dries after steaming, removing carpopodium and impurity.There is the effect of astringing lung-QI and relieving cough, nourishing arresting seminal emission, antidiarrheal hidroschesis.
Radix Salviae Miltiorrhizae is the dry root welding technology of labiate Radix Salviae Miltiorrhizae.Have blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, effect of removing heat from blood eliminating carbuncle.
Radix Polygoni Multiflori Preparata is the Radix Polygoni Multiflori will dried after Radix Polygoni Multiflori and the common steaming and decocting of Semen sojae atricolor.Radix Polygoni Multiflori Preparata has invigorating the liver and kidney, benefiting essence-blood, nourish heart the effect of allaying excitement.
Herba Taxilli is the dry stem and branch with leaf of Loranthaceae plant, removes thick stem, cutting, dry.Herba Taxilli has invigorating the liver and kidney, bone and muscle strengthening, effect of wind-damp dispelling, can be used for treating rheumatic arthralgia.
Radix Notoginseng is the dry root welding technology of panax araliaceae plant, sweet, micro-hardship, temperature.It has dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain.Water soluble ingredient dencichine in Radix Notoginseng is discharged blood coagulation substance by organism metabolism, induced platelet and is produced anastalsis.Radix Notoginseng total arasaponins has obvious anticoagulant, anticoagulant effect, anticoagulation, effect of namely invigorating blood circulation.Radix Notoginseng total arasaponins is obvious to Cardiovascular System, can protect cardiac muscle, resisting coronary heart disease, and protection cerebral tissue, expands blood vessel and blood pressure lowering.Radix Notoginseng total arasaponins also has calmness, analgesic effect.
The Radix Notoginseng total arasaponins contained in Radix Notoginseng can form with contaminated with lipid the material not easily absorbed in digestive tract, prevents lipid from depositing at Ink vessel transfusing, prevents arteriosclerosis, reduces blood lipid level.In addition, Radix Notoginseng has the effect promoting human body hemopoietic function, thus can improve hemoglobin, erythrocytic propagation, improves the consumption of lipid in blood.In addition, Radix Notoginseng can improve human body intestinal canal function, promotes intestinal peristalsis promoting, intestinal fluid secretion, can alleviate the symptom of human body constipation.
In addition, when health to have in hypertension, hyperlipidemia, hyperglycemia one or more, in body, the quantity of small thrombosis will be far longer than normal person, and at this moment, small thrombosis just becomes breakneck factor.Under certain condition, these small thrombosis can be assembled suddenly, form large thrombosis, artery-clogging, and myocardial infarction, cerebral infarction occur.Radix Notoginseng, by controlling hypertension, hyperlipidemia, hyperglycemia, reduces the quantity of small thrombosis, thus reduces the probability forming large thrombosis.Radix Notoginseng can effective antithrombus formation, thus stops the generation of cardiovascular and cerebrovascular disease.Promoting blood circulation to remove blood stasis effect that Radix Notoginseng powder has, energy antiplatelet aggregation, thus antithrombus formation.Effective ingredient is arasaponin, mainly panaxatriol's glycosides Rg1.Radix Notoginseng powder anti-thrombosis function link includes antiplatelet aggregation, antithrombase and promotion plasmin solution preocess.Radix Notoginseng powder can improve the content of cyclic adenosine monophosphate in platelet (cAMP), reduces the synthesis of thromboxane A2, thus suppresses Ca2
+, the short platelet aggregation such as 5-HT active substance release, play antiplatelet aggregative activity.
Ganoderma, Radix Notoginseng are matched, and fall a benefit by one, reduce blood lipid, strengthen patient body quality simultaneously.Radix Notoginseng and Ganoderma coordinate, and can promote the absorption to the effective ingredient in Ganoderma, also have certain facilitation simultaneously to the stability of effective ingredient.Radix Notoginseng then can exciting human self repair, function, both can coordinate to improve heart, function, control cardiovascular disease.Ganoderma can strengthen body immunity, regulates blood glucose, controls blood pressure, adjuvant therapy chemicotherapy, hepatoprotective, the significant curative effects such as hypnotic.So Radix Notoginseng, Ganoderma are monarch drug.
Chinese medicine composition for ministerial drug with Radix Ginseng, Radix Salviae Miltiorrhizae, the Radix Astragali, by promoting the metabolism in human body, improves the consumption of lipid in blood, thus reduces the object of blood fat.Radix Ginseng improves human body hemopoietic function, promotes the increase of erythrocyte, hemoglobin and platelet counts, is beneficial to attenuating blood viscosity, reduces Lipid Concentration in blood.The ginsenoside contained in Radix Ginseng can promote the lipid metabolism of human body, makes the biosynthesis of lipoprotein in cholesterol and blood, decomposition and inversion, excretion acceleration, Blood Cholesterol finally can be made to reduce.To some the relevant complication caused by hyperlipidemia, there is therapeutic effect, thus while blood fat reducing, the clinical complication of reduction of patient.
Radix Polygoni Multiflori Preparata, Fructus Schisandrae Chinensis, Herba Epimedii are adjuvant drug, play and strengthen human liver spleen cardio-pulmonary function, improve human internal organ vigor, be conducive to promoting human detoxification, detoxification ability, avoid blood fat to raise and then can improve human body immunity to the infringement of internal organs, delay soma aging.
Herba Taxilli, for making medicine, is in harmonious proportion the property of medicine of various medicine, enables various medicine play drug effect better, makes each drug synergism.
This Chinese medicine composition adopts natural vegetable Chinese herbal medicine, has no side effect, and by rational compatibility, increases the consumption of lipid in blood, improves internal organs vigor simultaneously, accelerate the excretion of lipid, consumption, thus reduce blood fat.In addition, utilize medical material to nurse one's health health, improve human body immunity, to the hypertension caused by hyperlipidemia, physical function decline etc., there is good prevention effect.By improving function of human body, promote that human body self is to the regulatory function of blood fat, controls serum lipid concentrations further.
Preferably, by weight,
Preferably, also comprise: pharmaceutically acceptable adjuvant.
Preferably, described adjuvant comprises Mel.Mel can be in harmonious proportion the bitterness of Chinese medicine.
Preferably, the Chinese medicine composition being used for the treatment of hyperlipidaemic conditions described in is Oral preparation.
The above-mentioned manufacture method being used for the treatment of the Chinese medicine composition of hyperlipidaemic conditions, comprises the following steps: weigh each raw material, pulverizes, mixes, to obtain final product.The method flow process is simple, operation side, can complete the making of Chinese medicine composition fast, reduces cost of manufacture and the production cycle of medicine.
The above-mentioned manufacture method being used for the treatment of the Chinese medicine composition of hyperlipidaemic conditions containing Radix Notoginseng, comprises the following steps:
Weigh each raw material, pulverize, mix, to obtain final product.
Preferably, described pulverizing is specially: pulverized in super micron mill by each raw material weighed, the operating temperature of super micron mill is 30 DEG C ~ 50 DEG C, and grinding time is 40 ~ 60 minutes.Can be fully broken by medical material by superfine communication technique, smashed by the cell wall of medical material, intracellular content is released, and is conducive to utilizing intracellular various active chemical, improves the absorption of human body to medicine.In addition, various medical material particle diameter is little, mixing evenly.The form that medicine is rolled into a ball with minuteness particle exists, and comprises identical various chemical compositions in each particle cluster.Grinding time has impact to its medical material particle diameter, grinding time is too short, and its particle diameter is unfavorable for greatly absorbing, and grinding time is long, can improve making and the processing cost of medical material, pulverize the later stage simultaneously, the change of size of medical material is little, and extending grinding time can increase processing cost, waste energy.
Preferably, the particle diameter being used for the treatment of the Chinese medicine composition of hyperlipidaemic conditions described in is 13 ~ 50 μm.Particle diameter is too small, and the manufacture difficulty of preparation increases, and improves cost of manufacture and the cycle of preparation.Particle diameter is excessive, then it takes inconvenience, is unfavorable for the digestion of human body, absorption.The particle diameter of this Chinese medicine preparation is little, after taking after mixing it with water, is easy to absorb in human small intestine, greatly can reduces dosage; If particle diameter is much, then human body tails off to its absorption, in order to reach identical effective dose, needing to increase dosage, thus can cause burden to internal organs such as the liver of patient, kidneys.
Preferably, before weighing each raw material, also comprise: clean each raw material, soaking and washing in purified water, then dry at 56 ~ 60 DEG C.By cleaning the dis-medicinal part in removing medical material, removing the product that go mouldy, product of damaging by worms, ash bits etc., making it reach medicinal standard.Remove the moisture in medical material through super-dry, conveniently to preserve, also can reduce medical material simultaneously and to go mouldy problem.Dry under cryogenic conditions, the activity of the various active chemicals in medical material can be kept, prevent temperature too high and cause active chemical to be destroyed, keep the medical value of medical material.
Preferably, after pulverizing, before mixing, also comprise: in the raw material after pulverizing, add adjuvant.Adjuvant has assosting effect, and it plays coordinative role to principal agent, and the effect such as heighten the effect of a treatment.
Beneficial effect of the present invention: the invention provides a kind of Chinese medicine composition with health care, has the effect of blood fat reducing, strong cardiopulmonary liver spleen.Present invention also offers a kind of Chinese medicine composition being used for the treatment of hyperlipidaemic conditions and preparation method thereof, this Chinese medicine preparation utilizes above-mentioned Chinese medicine composition, and carries out pulverization process by Crushing of Ultrafine technology, then mixes.Chinese crude drug is fully pulverized, and its particle diameter is little, and medicament is fine particle cluster structure, and the various effective ingredient in medical material are fully discharged, and are conducive to absorption of human body, utilization.
Accompanying drawing explanation
In order to be illustrated more clearly in the technical scheme of the embodiment of the present invention, be briefly described to the accompanying drawing used required in embodiment below, be to be understood that, the following drawings illustrate only some embodiment of the present invention, therefore the restriction to scope should be counted as, for those of ordinary skill in the art, under the prerequisite not paying creative work, other relevant accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 shows the Making programme figure of the herb in granule form in the embodiment of the present invention eight.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting the scope of the invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, be and can buy by commercially available the conventional products obtained.
Embodiment one
This enforcement provides a kind of Chinese medicine composition being used for the treatment of hyperlipidaemic conditions, comprises following component, by weight gram meter:
By above-mentioned each Chinese crude drug pulverizing, mixing, pack and get final product.This Chinese medicine preparation is granule, can be directly oral when taking, and also can take after mixing it with water with hot water, every day twice, each 3 grams.
Embodiment two
This enforcement provides a kind of Chinese medicine composition being used for the treatment of hyperlipidaemic conditions, comprises following component, by weight gram meter:
By above-mentioned Chinese crude drug pulverizing, mixing, adds Mel, is conventionally made as cataplasm of tcm.This cataplasm of tcm, melts with hot water, oral, every day twice, each 5 grams.
Embodiment three
This enforcement provides a kind of Chinese medicine composition being used for the treatment of hyperlipidaemic conditions, comprises following component, by weight gram meter:
By above-mentioned Chinese crude drug pulverizing mixing, conventionally, granulate, dry, the granule taken in obtaining, daily 1 time, each a slice.
Embodiment four
This enforcement provides a kind of Chinese medicine composition being used for the treatment of hyperlipidaemic conditions, comprises following component, by weight gram meter:
By above-mentioned Chinese crude drug pulverizing mixing, conventionally, granulate, filled capsules, the capsule taken in obtained.Daily twice, each 3 grams is good.
Radix Notoginseng has effect of softening stool, pseudo-ginseng blood-circulation-invigovating blood stasis dispelling, contributes to improving intestinal blood circulation, increases function of intestinal canal, promotes intestinal fluid secretion, increases enteral power, after taking this Chinese medicine capsules, and can the symptom of constipation relieving patient effectively.
Embodiment five
This enforcement provides a kind of Chinese medicine composition being used for the treatment of hyperlipidaemic conditions, comprises following component, by weight gram meter:
By above-mentioned Chinese crude drug pulverizing mixing, add starch, conventionally, tabletted, film coating, obtained Chinese medicinal tablet, daily a slice, chew and take.
Embodiment six
This enforcement provides a kind of Chinese medicine composition being used for the treatment of hyperlipidaemic conditions, comprises following component, by weight gram meter:
Above-mentioned Chinese medicine preparation is made by the following method:
The first step, cleans each medical material.
Second step, puts into purified water soaking and washing 20 minutes by the medical material after cleaning, then dry at 56 DEG C.
3rd step, utilizes Universalpulverizer to pulverize each medical material, and process of sieving, make herb in granule form.
4th step, is placed in herb in granule form in super micron mill, at 50 DEG C, pulverize 60 minutes to herb in granule form, and obtained medicinal powder, mean diameter reaches 45 μm.
5th step, by each medicinal powder Homogeneous phase mixing in homogenizer, to obtain final product.
In above-mentioned steps, by cleaning, removing medical material without the position of medical value, guaranteeing the quality of medicinal raw material.Soaking and washing in purified water, can remove the impurity on medical material surface, dust, then cold drying, prevents effective ingredient in medical material to be destroyed.
First medical material is pulverized by Universalpulverizer, after sieve, keep the homogeneity of herb in granule form.After pulverizing medicinal materials, then pulverized by super micron mill, reduce the particle diameter of medical material further.Because the particle diameter of medical material is little, after each medical material mixing, form tiny particle cluster, make preparation form the structure of numerous similar " capsule ", each " capsule " is inner containing more homogeneous various Chinese drugs powders.
In addition, by micronizing process, the cell wall of medical material can be broken, thus active chemical is wherein discharged.After Chinese crude drug mixing, active chemical more can disperse, mix, and is conducive to absorption and the utilization of human body.
This Chinese medicinal granule can be taken after mixing it with water by hot water, every day twice, each serving with 5 grams.
Embodiment seven
This enforcement provides a kind of Chinese medicine composition being used for the treatment of hyperlipidaemic conditions, and this Chinese medicine preparation comprises: Ganoderma 18 grams; The Radix Astragali 23 grams; Radix Ginseng 12 grams; Herba Epimedii 16 grams; Fructus Schisandrae Chinensis 12 grams; Radix Salviae Miltiorrhizae 26 grams; Radix Polygoni Multiflori Preparata 17 grams; Herba Taxilli 7 grams; Radix Notoginseng 218 grams.
Above-mentioned Chinese medicine preparation can be packed as 3 ~ 5 grams/bag, utilizes brewed in hot water to take during use, and one bag adds water 50 milliliters and steeps 10 minutes, is for twice daily good.
This Chinese medicine preparation makes by the following method:
The first step, cleans each medical material.
Second step, puts into purified water soaking and washing 10 minutes by the medical material after cleaning, then dry at 56 DEG C.
3rd step, utilizes Universalpulverizer to pulverize each medical material, and process of sieving, make herb in granule form.
4th step, is placed in herb in granule form in super micron mill, at 30 DEG C, pulverize 40 minutes to herb in granule form, and obtained medicinal powder, its mean diameter reaches 13 μm.
5th step, by each medicinal powder Homogeneous phase mixing in homogenizer, to obtain final product.
Embodiment eight
This enforcement provides a kind of Chinese medicine composition being used for the treatment of hyperlipidaemic conditions, and this Chinese medicine preparation comprises Ganoderma 13 grams; The Radix Astragali 10 grams; Radix Ginseng 15 grams; Herba Epimedii 20 grams; Fructus Schisandrae Chinensis 15 grams; Radix Salviae Miltiorrhizae 30 grams; Radix Polygoni Multiflori Preparata 20 grams; Herba Taxilli 1 gram; Radix Notoginseng 263 grams.
Consult Fig. 1, this Chinese medicine preparation makes by the following method:
The first step, cleans medical material, goes mouldy, corrupt, useless position to remove medical material.
Second step, by medical material purified water soaking and washing 24 minutes, removes the materials such as dust, then dry at 58 DEG C.
3rd, pulverizer is utilized to pulverize medical material, obtained herb in granule form.
4th step, utilizes super micron mill, pulverizes each herb in granule form and becomes the medicinal powder that mean diameter is 39 μm.
5th step, mixes each medicinal powder, to obtain final product.
This Chinese medicine is oral administration medicament, each 4 grams, soaks 15 minutes with 20 ml waters, daily twice.
Test example 1
To the efficacy analysis being used for the treatment of constipation Chinese medicine composition in embodiment four to eight.
Tested crowd: 300 constipation due to dry stool patients, wherein male 200 people, female 100 people, 25 ~ 50 years old age.
Test period: 5 days
Efficacy assessment standard:
Cure---defecation 1 time in 2 days, just matter turns profit, and unobstructed during solution, short-term is without recurrence.
Taking a turn for the better---defecation in 3 days, just matter turns profit, owes smooth during solution.
Not healing---symptom is without improvement.
Effective percentage: (curing number of cases+improvement number of cases)/total number of cases × 100%
Test result: 196 people cure, 76 people take a turn for the better, and effective percentage reaches 90%.
Test example 2
To the efficacy analysis being used for the treatment of the Chinese medicine composition of hyperlipidaemic conditions in embodiment one to eight.
Tested crowd: male 250 people, female 120 people, at 36 ~ 55 years old age, experimenter's blood fat raises, and the cholesterol in blood, triglyceride are all higher than normal level.
Test period: 2 months
Efficacy assessment standard:
Effective---lipids detection reaches following any one: T-CHOL (TC) declines >=20%, and triglyceride (TG) declines >=40%.
Effectively---lipids detection reaches following any one: T-CHOL (TC) declines >=10% but <20%, and triglyceride (TG) declines >=20% but <40%.
Invalid---lipids detection does not reach above standard person.
Test result: 20 people's cholesterol are still higher than normally, and another 2 people leak visit, 335 people's blood fat recover normal, and wherein 215 people are remarkable, and 120 people are effective.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. be used for the treatment of a Chinese medicine composition for hyperlipidaemic conditions, it is characterized in that, be prepared from primarily of compositions A, described compositions A comprises following composition: by weight:
2. the Chinese medicine composition being used for the treatment of hyperlipidaemic conditions according to claim 1, is characterized in that, by weight,
3. the Chinese medicine composition being used for the treatment of hyperlipidaemic conditions according to claim 2, is characterized in that, also comprise: pharmaceutically acceptable adjuvant.
4. the Chinese medicine composition being used for the treatment of hyperlipidaemic conditions according to claim 2, is characterized in that, described in be used for the treatment of hyperlipidaemic conditions Chinese medicine composition be Oral preparation.
5. the manufacture method being used for the treatment of the Chinese medicine composition of hyperlipidaemic conditions according to claim 1, is characterized in that, comprise the following steps:
Weigh each raw material, pulverize, mix, to obtain final product.
6. the manufacture method being used for the treatment of the Chinese medicine composition of hyperlipidaemic conditions according to claim 2, is characterized in that, comprise the following steps:
Weigh each raw material, pulverize, mix, to obtain final product.
7. the manufacture method being used for the treatment of the Chinese medicine composition of hyperlipidaemic conditions according to claim 6, it is characterized in that, described pulverizing is specially: pulverized in super micron mill by each raw material weighed, the operating temperature of super micron mill is 30 DEG C ~ 50 DEG C, and grinding time is 40 ~ 60 minutes.
8. the manufacture method being used for the treatment of the Chinese medicine composition of hyperlipidaemic conditions according to claim 7, is characterized in that, raw material particle diameter is after crushed 13 ~ 50 μm.
9. the manufacture method being used for the treatment of the Chinese medicine composition of hyperlipidaemic conditions according to claim 6, is characterized in that, before weighing each raw material, also comprises: clean each raw material, soaking and washing in purified water, then dry at 56 ~ 60 DEG C.
10. the manufacture method being used for the treatment of the Chinese medicine composition of hyperlipidaemic conditions according to claim 6, is characterized in that, after pulverizing, before mixing, also comprises: in the raw material after pulverizing, add adjuvant.
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CN109793867A (en) * | 2017-11-14 | 2019-05-24 | 仝二法 | Blood fat-reducing blood pressure-decreasing medicinal herb tea |
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CN109793867A (en) * | 2017-11-14 | 2019-05-24 | 仝二法 | Blood fat-reducing blood pressure-decreasing medicinal herb tea |
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