CN104524537A - Pharmaceutical composition for treating chronic enteritis - Google Patents
Pharmaceutical composition for treating chronic enteritis Download PDFInfo
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- CN104524537A CN104524537A CN201510033595.5A CN201510033595A CN104524537A CN 104524537 A CN104524537 A CN 104524537A CN 201510033595 A CN201510033595 A CN 201510033595A CN 104524537 A CN104524537 A CN 104524537A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8884—Arisaema, e.g. Jack in the pulpit
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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Abstract
The invention relates to a pharmaceutical composition for treating chronic enteritis. The pharmaceutical composition comprises the following raw materials in parts by weight: 10-40 parts of ramulus cinnamomi, 5-25 parts of fructus amomi, 5-35 parts of raw rhizoma atractylodis macrocephalae, 10-40 parts of rhizoma cimicifugae, 5-25 parts of honey-fried liquorice root, 10-40 parts of ginger, 5-40 parts of angelica sinensis, 5-45 parts of radix rehmanniae preparata and 5-30 parts of radix polygoni multiflori. The traditional Chinese medicine composition disclosed by the invention is capable of treating both symptoms and root causes, treating excess and deficiency, tonifying deficiency and relieving diarrhea on the basis of the principle of combination of disease differentiation and syndrome differentiation on treatment of chronic enteritis; natural Chinese herbal medicines capable of enriching vigor, tonifying the spleen and kidneys, and enriching qi and blood are screened out; the pharmaceutical composition has a significant curative effect on treatment of the chronic enteritis; various Chinese herbal medicines are coordinated with each other to take the maximal medicine effect; the healing ability on patients can be effectively improved; and in addition, the pharmaceutical composition is small in side effect and low in cost, and can be accepted by wide patients with chronic enteritis.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of chronic enteritis, especially relating to a kind of take Chinese herbal medicine as the pharmaceutical composition of the treatment chronic enteritis of raw material.
Background technology
According to Ministry of Public Health recent statistics, some people of China suffer from chronic enteritis and through in, western medical treatment still presents cureless state, this type of patient suffers from the risk of intestinal cancer far above other crowds, should cause the attention of medical circle.Up to the present, treat in the medicine of chronic enteritis for tens of kinds that have gone on the market, also do not have one thoroughly can cure chronic enteritis and side effect is large.
Summary of the invention
Technical problem to be solved by this invention overcomes above-described defect, provide a kind of efficient, significantly, the pharmaceutical composition of cost is lower, side effect is little treatment chronic enteritis.
To achieve these goals, the invention provides following technical scheme:
Treat a pharmaceutical composition for chronic enteritis, comprise the raw material of following weight portion: RAMULUS CINNAMOMI 10 ~ 40 parts, Fructus Amomi 5 ~ 25 parts, Rhizoma Atractylodis Macrocephalae 5 ~ 35 parts, Rhizoma Cimicifugae 10 ~ 40 parts, Radix Glycyrrhizae Preparata 5 ~ 25 parts, 10 ~ 40 parts, Rhizoma Zingiberis Recens, Radix Angelicae Sinensis 5 ~ 40 parts, 5 ~ 45 parts, Radix Rehmanniae Preparata, the Radix Polygoni Multiflori 5 ~ 30 parts.
Be preferably, the pharmaceutical composition of described treatment chronic enteritis, comprises the raw material of following weight portion: RAMULUS CINNAMOMI 20 parts, Fructus Amomi 20 parts, Rhizoma Atractylodis Macrocephalae 15 parts, Rhizoma Cimicifugae 20 parts, Radix Glycyrrhizae Preparata 15 parts, 20 parts, Rhizoma Zingiberis Recens, Radix Angelicae Sinensis 30 parts, 20 parts, Radix Rehmanniae Preparata, the Radix Polygoni Multiflori 20 parts.
The pharmaceutical composition of described treatment chronic enteritis, also comprises the raw material of following weight portion: Poria cum Radix Pini 5 ~ 40 parts, Fructus Psoraleae 5 ~ 40 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5 ~ 25 parts, Rhizoma Arisaematis (processed) 5 ~ 25 parts, golden Rhizoma Cibotii 5 ~ 45 parts.
Be preferably, the pharmaceutical composition of described treatment chronic enteritis, also comprises the raw material of following weight portion: Poria cum Radix Pini 25 parts, Fructus Psoraleae 20 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15 parts, Rhizoma Arisaematis (processed) 15 parts, golden Rhizoma Cibotii 20 parts.
Pharmaceutical composition of the present invention in the preparation, can add the adjuvant of the different various routines needed for dosage form of preparation, such as: disintegrating agent, lubricant, adhesive.Described drug regimen can be made into pharmaceutically acceptable dosage form, and described dosage form is the one in capsule, pill, granule.
Usage and consumption: dosage of the present invention just depends on the factor such as age, body weight, health status of concrete dosage form, patient, conventional dose is as follows:
(1) capsule: take three every day, each 4-8 grain, every content of dispersion 0.5g, warm water takes;
(2) granule: take three every day, each bag, often wrap 8g, warm water takes;
(3) pill: take three every day, each 8g, warm water takes.
Within one month, be a course for the treatment of, treat three courses for the treatment of altogether.
Beneficial effect of the present invention is: Chinese medicine composition of the present invention is based on the differential diagnosis of diseases of Chinese medicine chronic enteritis disease and the dialectical principle combined, treating both the principal and secondary aspects of a disease, deficiency and excess and control, tonify deficiency lets out reality, filter out the natural middle forage of supplement vigour, strengthening spleen, tonifying kidney, benefiting vital QI and blood, to treatment chronic enteritis, there is the curative effect of highly significant and various middle forage is coordinated together mutually, farthest can play drug effect, effectively can improve the healing power to patient, in addition, side effect of the present invention is little, expense is low, can be accepted by vast chronic enteritis.
Detailed description of the invention
Further describe the present invention by the following examples, it should be understood that these embodiments only for the object of illustration, never limit the scope of the invention.
Embodiment 1: the preparation of capsule
Each raw material is taken: RAMULUS CINNAMOMI 20 parts, Fructus Amomi 20 parts, Rhizoma Atractylodis Macrocephalae 15 parts, Rhizoma Cimicifugae 20 parts, Radix Glycyrrhizae Preparata 15 parts by following weight portion, 20 parts, Rhizoma Zingiberis Recens, Radix Angelicae Sinensis 30 parts, 20 parts, Radix Rehmanniae Preparata, the Radix Polygoni Multiflori 20 parts, Poria cum Radix Pini 25 parts, Fructus Psoraleae 20 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15 parts, Rhizoma Arisaematis (processed) 15 parts, golden Rhizoma Cibotii 20 parts.
Incapsulate being ground into after fine powder crosses 1500 mesh sieves after each component mixing of above-mentioned weight and get final product.
Embodiment 2: the preparation of granule
Each raw material is taken: RAMULUS CINNAMOMI 20 parts, Fructus Amomi 20 parts, Rhizoma Atractylodis Macrocephalae 15 parts, Rhizoma Cimicifugae 20 parts, Radix Glycyrrhizae Preparata 15 parts by following weight portion, 20 parts, Rhizoma Zingiberis Recens, Radix Angelicae Sinensis 30 parts, 20 parts, Radix Rehmanniae Preparata, the Radix Polygoni Multiflori 20 parts, Poria cum Radix Pini 25 parts, Fructus Psoraleae 20 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15 parts, Rhizoma Arisaematis (processed) 15 parts, golden Rhizoma Cibotii 20 parts.
By being ground into after fine powder crosses 1500 mesh sieves after the mixing of each component of above-mentioned weight, adding ethanol and making adhesive, adding starch and make filler, be pressed into granule.
Embodiment 3: the preparation of pill
Each raw material is taken: RAMULUS CINNAMOMI 20 parts, Fructus Amomi 20 parts, Rhizoma Atractylodis Macrocephalae 15 parts, Rhizoma Cimicifugae 20 parts, Radix Glycyrrhizae Preparata 15 parts by following weight portion, 20 parts, Rhizoma Zingiberis Recens, Radix Angelicae Sinensis 30 parts, 20 parts, Radix Rehmanniae Preparata, the Radix Polygoni Multiflori 20 parts, Poria cum Radix Pini 25 parts, Fructus Psoraleae 20 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15 parts, Rhizoma Arisaematis (processed) 15 parts, golden Rhizoma Cibotii 20 parts.
To be ground into after fine powder crosses 80-200 mesh sieve after the mixing of each component of above-mentioned weight, obtained pill.
Embodiment 4: the present invention treats the Clinical efficacy test of patients having chronic intestinal inflammation
(1) subjects
Clinical case: 46 example, wherein man 26 example, female 20 example, age 10-56 year between.
(2) Therapeutic Method
(1) capsule: take three every day, each 4-8 grain, every content of dispersion 0.5g, warm water takes;
(2) granule: take three every day, each bag, often wrap 8g, warm water takes;
(3) pill: take three every day, each 8g, warm water takes.
Within one month, be a course for the treatment of, treat three courses for the treatment of altogether.
(3) efficacy assessment standard
Effective: Signs is significantly improved, show as diarrhoea stoppings, stool routine examination, pus cell obviously reduce or be feminine gender.
Effective: Signs is improved, showing as diarrhoea take a turn for the better and the intermission obviously extends, stool routine examination, pus cell reduce to some extent.
Invalid: Signs without improvement, the frequency of diarrhoea with take medicine front similar, stool routine examination basic with take medicine before the same.
(4) diagnostic result
In treated 46 routine patients, after treating three courses for the treatment of, wherein, effective account for 19 examples, effectively account for 24 examples, invalid 3 examples, total effective rate reaches: 93.5%.Can find out that the treatment of the drug regimen of Chinese medicine of the present invention to B-type hepatitis has significant curative effect from the above results.
Model case
Case 1: Liu, man, 45 years old, Fuyang City
Patient's recurrent diarrhea has 3 years, slightly suffers from cold and namely feels stomachache, show diarrhoea subsequently, every day 7-8 time, defecate rare shapeless, treat through Chinese and Western, curative effect is not obvious, withdraw other drug, oral drug regimen of the present invention, after first quarter moon, patients symptomatic is clearly better, after 3 courses for the treatment of, patient's symptom of diarrhea takes a turn for the better completely, stool routine examination.
Case history 2: open up certain, female, 24 years old, Huainan City
Namely there is chronic enteritis, recurrent diarrhea in weak 15 years old since the childhood in patient, each outbreak continues 10-15 days, between stage of attack, suffers from diarrhoea every day 5 ~ 6 times, can reach 8 ~ 9 times time serious, through Chinese and Western treatment, still occurs the phenomenon of recurrent exerbation.In May, 2012, oral medicine of the present invention is after 10 days, and symptom takes a turn for the better to some extent, and after 3 courses for the treatment of, patient's symptom of diarrhea turns for the better by and large, stool routine examination, still has a small amount of pus cell, and continue afterwards to take a course for the treatment of, symptom takes a turn for the better completely.
Case history 3: high certain, man, 12 years old, Huainan City
Patient since the childhood dietary habit is poor, often eats raw food, cold and cool food, and cause occurring recurrent diarrhea when 8 years old, Jing Guozhong, western medical treatment, curative effect is not obvious.After taking medicine two weeks of the present invention in June, 2012, patient's symptom of diarrhea takes a turn for the better to some extent, and after 3 courses for the treatment of, patient's symptom of diarrhea turns for the better by and large, stool routine examination, still has a small amount of pus cell.
Claims (6)
1. treat the pharmaceutical composition of chronic enteritis for one kind, it is characterized in that, comprise the raw material of following weight portion: RAMULUS CINNAMOMI 10 ~ 40 parts, Fructus Amomi 5 ~ 25 parts, Rhizoma Atractylodis Macrocephalae 5 ~ 35 parts, Rhizoma Cimicifugae 10 ~ 40 parts, Radix Glycyrrhizae Preparata 5 ~ 25 parts, 10 ~ 40 parts, Rhizoma Zingiberis Recens, Radix Angelicae Sinensis 5 ~ 40 parts, 5 ~ 45 parts, Radix Rehmanniae Preparata, the Radix Polygoni Multiflori 5 ~ 30 parts.
2. the pharmaceutical composition for the treatment of chronic enteritis according to claim 1, is characterized in that, comprises the raw material of following weight portion: RAMULUS CINNAMOMI 20 parts, Fructus Amomi 20 parts, Rhizoma Atractylodis Macrocephalae 15 parts, Rhizoma Cimicifugae 20 parts, Radix Glycyrrhizae Preparata 15 parts, 20 parts, Rhizoma Zingiberis Recens, Radix Angelicae Sinensis 30 parts, 20 parts, Radix Rehmanniae Preparata, the Radix Polygoni Multiflori 20 parts.
3. the pharmaceutical composition for the treatment of chronic enteritis according to claim 1, is characterized in that, also comprises the raw material of following weight portion: Poria cum Radix Pini 5 ~ 40 parts, Fructus Psoraleae 5 ~ 40 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5 ~ 25 parts, Rhizoma Arisaematis (processed) 5 ~ 25 parts, golden Rhizoma Cibotii 5 ~ 45 parts.
4. the pharmaceutical composition for the treatment of chronic enteritis according to claim 3, is characterized in that, Poria cum Radix Pini 25 parts, Fructus Psoraleae 20 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15 parts, Rhizoma Arisaematis (processed) 15 parts, golden Rhizoma Cibotii 20 parts.
5. the pharmaceutical composition of any one treatment chronic enteritis according to claims 1 to 4, it is characterized in that, described pharmaceutical composition can be made into the common oral formulations of any one.
6. the pharmaceutical composition for the treatment of chronic enteritis according to claim 5, is characterized in that, described oral formulations is the one in pill, capsule or granule.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104644927A (en) * | 2015-01-26 | 2015-05-27 | 陆宇 | Pharmaceutical composition for treating caecum inflammation |
CN110840972A (en) * | 2019-11-15 | 2020-02-28 | 湖北理工学院 | Traditional Chinese medicine composition for treating enteritis |
CN110876790A (en) * | 2019-11-15 | 2020-03-13 | 湖北理工学院 | Traditional Chinese medicine preparation for treating enteritis |
Citations (1)
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CN101543617A (en) * | 2008-03-28 | 2009-09-30 | 天科仁祥技术(北京)有限责任公司 | Traditional Chinese medicine composition for curing colonitis and preparation method thereof |
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2015
- 2015-01-22 CN CN201510033595.5A patent/CN104524537A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101543617A (en) * | 2008-03-28 | 2009-09-30 | 天科仁祥技术(北京)有限责任公司 | Traditional Chinese medicine composition for curing colonitis and preparation method thereof |
Non-Patent Citations (2)
Title |
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柏汝炜: "苓桂术甘汤加味治验二则", 《中医杂志》 * |
蔺振玉: "通因通用治顽泻", 《上海中医药杂志》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104644927A (en) * | 2015-01-26 | 2015-05-27 | 陆宇 | Pharmaceutical composition for treating caecum inflammation |
CN110840972A (en) * | 2019-11-15 | 2020-02-28 | 湖北理工学院 | Traditional Chinese medicine composition for treating enteritis |
CN110876790A (en) * | 2019-11-15 | 2020-03-13 | 湖北理工学院 | Traditional Chinese medicine preparation for treating enteritis |
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