CN102755378B - Traditional Chinese medicine composition for preventing and treating osteoporosis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating osteoporosis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal composition for preventing and treating osteoporosis and a preparation method thereof. According to the adopted technical scheme, the Chinese medicinal composition is prepared from the following bulk pharmaceuticals in parts by weight: 5-30 parts of suchow mosla herb, 5-30 parts of six-eared blumea, 5-30 parts of plumbago indica and 5-30 parts of garter snake. Under the guidance of a traditional Chinese medicine principle, various medicinal materials are matched reasonably and play synergic actions, so that a definite treatment effect on osteoporosis is achieved.
Description
Technical field
The present invention relates to Chinese medicine composition of a kind of prevention and treatment osteoporosis and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Osteoporosis (Osteoporosis, OP) is the osteopathia that many reasons causes, is because unit volume internal skeleton tissue mass reduces, the bone fine structure destroys, and causes the fragility of bone to increase, the normal easy a kind of chronic general skeletal diseases that osteodynia is even fractured that occurs.Osseous tissue has normal calcification, and calcium salt and substrate are normal ratio, and the metabolic osteopathy that is reduced to characteristics with unit volume internal skeleton tissue mass becomes.In most osteoporosises, due to the minimizing of osseous tissue increases mainly due to bone absorption.Morbidity is how slowly indivedual very fast, take skeleton pain, to be easy to fracture be feature biochemical analysis normal.
Osteoporosis can be divided into constitutional and the large class of Secondary cases two, primary osteoporosis (Primary osteoporosis, POP) can be divided into again senile osteoporosis and postmenopausal osteoporosis (Postmenopausal osteoporosis, PMO).POP is a kind of common senile disease, this disease and complication fracture thereof, induced pain, disables, early death human health is formed to great threat, how to prevent and treat and has become important public health problem.
The main purpose of clinical treatment OP is prevention or the danger that reduces further bone loss, bone mass increasing and reduction fracture; Control OP medicine has a lot, according to mechanism of action, can be divided into two classes: the one, suppress the bone resorption medicine, and mainly contain estrogen, calcitonin, diphosphonates, ipriflavone etc.; The 2nd, short bone formation medicine, mainly contain the bone mineralizer: as calcium salt, vitamin D and derivant thereof, androgen, growth hormone, fluoride, protein anabolic hormone etc.
The present invention be take Chinese crude drug as raw material, for pathogenesis and the clinical symptoms of osteoporosis, plays the effect that increases bone density, thereby reaches the purpose of Prevention and Treatment of Osteoporosis.
Chinese invention patent publication number CN102145106A discloses " a kind of Chinese medicine composition and invigorating kidney, promoting blood circulation granule for the treatment of osteoporosis ", Radix Rehmanniae Preparata, the Cortex Eucommiae, Radix Aconiti Lateralis Preparata, Fructus Lycii, Cortex Cinnamomi, Fructus Corni, Semen Persicae, Flos Carthami, Rhizoma Dioscoreae, Radix Glycyrrhizae, consists of; Chinese invention patent publication number CN102233028A discloses " a kind of Chinese medicine composition for the treatment of osteoporosis ", Flos Carthami, Radix Notoginseng, the Radix Astragali, Radix Ginseng part, the Cortex Eucommiae, Pericarpium Citri Reticulatae, consists of.Chinese invention patent publication number CN102302537A disclosed " a kind of Chinese medicine composition for the treatment of osteoporosis " is comprised of Herba Epimedii, cervus elaphus linnaeus, Rhizoma Drynariae, the Cortex Eucommiae, Concha Ostreae.Chinese invention patent publication number CN101112445A discloses " Chinese medicinal formulae for the treatment of osteoporosis ", mainly Radix Rehmanniae Preparata, Herba Cistanches, Herba Epimedii, Rhizoma Drynariae, the Cortex Eucommiae, the Radix Astragali, Radix Angelicae Sinensis etc., consist of, this medicine plays the effect of nourishing the liver and kidney, bone and muscle strengthening, promoting blood circulation and stopping pain.Chinese invention patent publication number CN101143165A discloses " containing the compositions of Cistanche Tubulosa and extract for treating osteoporosis thereof ", and it is usingd Cistanche Tubulosa water or other solvent extractable matters and is applied to the treatment of osteoporosis as active component.Chinese invention patent publication number CN101138597A discloses " Chinese medicine preparation of a kind of Prevention and Treatment of Osteoporosis and preparation method thereof ", mainly by Fructus Psoraleae, Radix Rehmanniae Preparata, Herba Epimedii, Radix Salviae Miltiorrhizae, Concha Ostreae etc., formed, play invigorating the kidney and strengthening the bones, reach the Prevention and Treatment of Osteoporosis effect.The combination that Chinese crude drug is raw material treatment osteoporosis at present, it is main being mostly for " the kidney invigorating " this pathogenic characteristic.
Summary of the invention
The object of the invention is to provide a kind of Chinese medicine composition, and under Chinese medical theory instructs, the rational proportion by each Chinese crude drug, play synergism, and Prevention and Treatment of Osteoporosis is had to clear and definite therapeutical effect.
Another one purpose of the present invention is to provide the preparation method of this Chinese medicine composition.
For achieving the above object, the technical solution used in the present invention is: a kind of Chinese medicine composition with Prevention and Treatment of Osteoporosis effect is to be made by the crude drug of following weight portion: Herba Moslae Soochowensis 5-30 part, Herba Blumeae Laciniatae 5-30 part, Herba plumbaginis indicae 5-30 part, Zaocys 5-30 part.
The traditional Chinese medicinal composition raw materials weight portion that preferably has the Prevention and Treatment of Osteoporosis effect consists of: 12 parts of Herba Moslae Soochowensiss, 12 parts of the Herba Blumeae Laciniataes, 12 parts of Herba plumbaginis indicaes, 9 parts of Zaocyss.
Chinese medicine composition of the present invention can adopt the Chinese medicine preparation conventional method to be prepared into conventional oral formulations, as tablet, capsule, oral liquid, electuary etc.
The preparation method of Chinese medicine composition of the present invention is: Herba Moslae Soochowensis, the Herba Blumeae Laciniatae, Herba plumbaginis indicae, Zaocys are mixed according to above-mentioned weight ratio, add 6-8 times of water gaging of total raw material medicine to soak 1-2 hour, heating decocts 1-1.5 hour, filter, medicinal residues add 6-8 times of water gaging again, and heating decocts 0.5-1 hour, filter, filtrate merges, and obtains supernatant; When supernatant concentration is 1.05-1.06 to relative density, advance spray dryer, inlet temperature is controlled 130-150 ℃, leaving air temp 100-120 ℃, and charging rate is 3-5ml/ minute, obtains spray drying powder, pulverizes, and after sieving, can obtain fine powder.
Using above-mentioned spray drying gained fine powder as active component, those skilled in the art can be according to the common technology of this area, choose the various conventional adjuvant of needs while preparing different dosage form, adjuvant as conventional as lubricant, binding agent etc., preparation method by Chinese medicine preparation conventional in prior art is made the common Chinese medicine preparation formulation, as tablet, capsule, oral liquid, electuary etc.
In the Chinese medicine composition of Prevention and Treatment of Osteoporosis effect of the present invention: Herba Moslae Soochowensis, property is hot, warm, and effect is the detoxicating, relieving inflammation analgesia; The Herba Blumeae Laciniatae, property is hot, bitter, and effect is the dispelling wind and removing obstruction in the collateral pain relieving; Herba plumbaginis indicae, property is hot, warm, effect for dispeling the wind, promoting blood circulation and stopping pain; Zaocys, property is sweet, flat, and effect is the dispelling wind and removing obstruction in the collateral pain relieving.Above-mentioned four Chinese medicine combination, have expelling wind and activating blood circulation pain relieving effect, thereby play the Prevention and Treatment of Osteoporosis effect.
The invention has the beneficial effects as follows: Chinese medicine composition of the present invention is under instruction of Chinese Medicine theory, and the main pathogenesis of specific aim osteoporosis, improve patient's bone pain symptom, take the expelling wind and activating blood circulation pain relieving as Therapeutic Method, reaches the therapeutical effect of Prevention and Treatment of Osteoporosis.The present invention is by the rational proportion of each medical material, and synergism, have significant curative effect to Prevention and Treatment of Osteoporosis, and is the common Chinese medicine material to the raw material of Chinese medicine composition, but long-term taking.
The present invention is directed to osteoporotic etiology and pathogenesis and clinical symptoms, play the increase bone density, improve serum calcium, the effect of squama content in body, thereby reach the purpose of Prevention and Treatment of Osteoporosis.
The specific embodiment
Below in conjunction with embodiment, the invention will be further elaborated
Embodiment 1 tablet preparation of the present invention
Take each crude drug by following weight proportion: Herba Moslae Soochowensis 120 grams, the Herba Blumeae Laciniatae 120 grams, Herba plumbaginis indicae 120 grams, Zaocys 90 grams.Add 8 times of water gagings of total raw material medicine to soak 1.5 hours above-mentioned weight proportion, heating decocts 1.5 hours, filters, and medicinal residues add 8 times of water gagings again, and heating decocts 1 hour, filters, and filtrate merges, and obtains supernatant; Supernatant concentration to relative density is 1.06 o'clock, advances spray dryer, and inlet temperature is controlled 140 ℃, 110 ℃ of leaving air temps, and charging rate is 5ml/ minute, obtains spray drying powder 18 grams, pulverizes spray drying powder and becomes fine powder.By above-mentioned fine powder technique routinely, add the adjuvant granulation, drying, tabletting.
Embodiment 2 capsule preparation of the present invention
Take each crude drug by following weight proportion: Herba Moslae Soochowensis 50 grams, the Herba Blumeae Laciniatae 50 grams, Herba plumbaginis indicae 50 grams, Zaocys 50 grams.Add 6 times of water gagings of total raw material medicine to soak 1.5 hours above-mentioned weight proportion, heating decocts 1.5 hours, filters, and medicinal residues add 6 times of water gagings again, and heating decocts 1 hour, filters, and filtrate merges, and obtains supernatant; Supernatant concentration to relative density is 1.06 o'clock, advances spray dryer, and inlet temperature is controlled 140 ℃, 110 ℃ of leaving air temps, and charging rate is 5ml/ minute, obtains spray drying powder 8 grams, pulverizes spray drying powder and becomes fine powder.By above-mentioned fine powder technique routinely, add adjuvant, mix the snap fit capsule of packing into.
Embodiment 3 granule preparation of the present invention
Take each crude drug by following weight proportion: Herba Moslae Soochowensis 300 grams, the Herba Blumeae Laciniatae 300 grams, Herba plumbaginis indicae 300 grams, Zaocys 300 grams are standby.Add 8 times of water gagings of total raw material medicine to soak 1.5 hours above-mentioned weight proportion, heating decocts 1.5 hours, filters, and medicinal residues add 8 times of water gagings again, and heating decocts 1 hour, filters, and filtrate merges, and obtains supernatant; Supernatant concentration to relative density is 1.06 o'clock, advances spray dryer, and inlet temperature is controlled 140 ℃, 110 ℃ of leaving air temps, and charging rate is 5ml/ minute, obtains spray drying powder 50 grams, pulverizes spray drying powder and becomes fine powder.By above-mentioned fine powder technique routinely, add adjuvant, mix the granulation agent.
Below in conjunction with experimental example, the invention will be further elaborated
Experimental example 1
1 experimental technique
50 of the female sd inbred rats at three monthly ages, be divided into 5 groups at random, i.e. matched group, model group, high, medium and low three the dosage groups of administration, 10 every group.Except matched group, all the other four groups of rat skin lower injection first are sprinkled Buddhist nun 3.5mg/kg, every day 1 subcutaneous injection, continuous 60 days.Administration group gavage simultaneously gives Chinese medicine composition of the present invention, the traditional Chinese medicine composition water decocting liquid adopts conventional decocting method preparation, and the simmer down to respective concentration, and decocting liquid various dose group comprises low dose group (7.5g/kg), middle dosage group (15g/kg), high dose group (30g/kg); Gastric infusion is respectively organized in medication, and all the other each groups gavage the normal saline of equivalent, and experiment successive administration totally 60 days is measured rat body bone density (BMD), rat blood serum calcium and phosphorus content after administration.
2 experimental results
After each treated animal administration of above-mentioned experiment, every experimental result sees the following form 1.
Table 1 Chinese medicine composition of the present invention is on the every evaluation index impact of laboratory animal
* representative is compared P<0.05 with matched group; The * representative is compared with model group, P<0.05
Above-mentioned results of animal shows: relatively, each is organized bone density and all significantly reduces (P<0.05), shows that experimental animal model is successfully prepared for model group and matched group; Each dosage group serum calcium of administration, phosphorus content, the whole body bone density all has rising in various degree, with model group, relatively has significant difference (P<0.05), and content of mineral substances in Chinese medicine composition energy control agent of the present invention is described, increase bone density, osteoporosis is had to preventive and therapeutic effect.
Claims (3)
1. the Chinese medicine composition with Prevention and Treatment of Osteoporosis effect, is characterized in that this Chinese medicine composition is to be made by the crude drug of following weight portion: 12 parts of Herba Moslae Soochowensiss, 12 parts of the Herba Blumeae Laciniataes, 12 parts of Herba plumbaginis indicaes, 9 parts of Zaocyss.
2. a kind of preparation method with Chinese medicine composition of Prevention and Treatment of Osteoporosis effect claimed in claim 1 is characterized in that preparation method is as follows:
1) by proportioning claimed in claim 1, take each crude drug standby;
2) add 6-8 times of water gaging of total raw material medicine to soak 1-2 hour, heating decocts 1-1.5 hour, filters; Medicinal residues add 6-8 times of water gaging again, and heating decocts 0.5-1 hour, filter, and filtrate merges, and obtains supernatant;
When 3) supernatant concentration to relative density is 1.05-1.06, advance spray dryer, inlet temperature is controlled 130-150 ℃, leaving air temp 100-120 ℃, and charging rate is 3-5ml/ minute, obtains spray drying powder.
3. Chinese medicine composition according to claim 1, be prepared into conventional oral formulations by it.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201210044044 CN102755378B (en) | 2012-02-24 | 2012-02-24 | Traditional Chinese medicine composition for preventing and treating osteoporosis and preparation method thereof |
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| CN 201210044044 CN102755378B (en) | 2012-02-24 | 2012-02-24 | Traditional Chinese medicine composition for preventing and treating osteoporosis and preparation method thereof |
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| CN102755378A CN102755378A (en) | 2012-10-31 |
| CN102755378B true CN102755378B (en) | 2013-12-25 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181422A (en) * | 2007-11-21 | 2008-05-21 | 北京中科雍和医药技术有限公司 | Nutrition health products for curing osteosporosis and rheumatic osteoarthropathy as well as preparation method |
| CN101380359A (en) * | 2008-10-20 | 2009-03-11 | 浙江省中医药研究院 | Jiangu capsules and preparation method thereof |
-
2012
- 2012-02-24 CN CN 201210044044 patent/CN102755378B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181422A (en) * | 2007-11-21 | 2008-05-21 | 北京中科雍和医药技术有限公司 | Nutrition health products for curing osteosporosis and rheumatic osteoarthropathy as well as preparation method |
| CN101380359A (en) * | 2008-10-20 | 2009-03-11 | 浙江省中医药研究院 | Jiangu capsules and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 健骨丸;樊春洲;《实用中西医结合杂志》;19931231;第6卷(第9期);541-542 * |
| 樊春洲.健骨丸.《实用中西医结合杂志》.1993,第6卷(第9期),541-542. |
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