CN104667255A - Traditional Chinese medicinal preparation used for treating diabetes mellitus - Google Patents
Traditional Chinese medicinal preparation used for treating diabetes mellitus Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal preparation for treating diabetes mellitus. The traditional Chinese medicinal preparation for treating the diabetes mellitus is prepared from major materials and auxiliary materials, wherein the major materials comprise 10-30 parts of monomer-pistil astragalus, 9-15 parts of white skin of Chinese aralis, 18-30 parts of peach gum, 20-40 parts of pilea pumila, 25-45 parts of common nepenthes, 12-20 parts of rauwolfia, 0.8-1.2 parts of ranunculus chinensis bunge, 24-60 parts of amillariella mellea, 15-45 parts of broad bean flower, 4-10 parts of pagodatree pod and 6-15 parts of dioscorea nipponica, and the auxiliary materials comprise 0.25-0.35 part of turmerol extract, 0.01-0.03 part of S-adenosyl-L-methionine, 0.008-0.012 part of glutathione, 0.03-0.06 part of antioxidant, 0.6-0.9 part of an excipient and 1.2-3.0 parts of a sweetening agent. The traditional Chinese medicinal preparation for treating the diabetes mellitus is rigorous in composition, reasonable in compatibility, high in active ingredient content and obvious in pharmaceutical effect, takes effect quickly, produces no side effect and is safe and secure.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically relate to a kind of Chinese medicine preparation for the treatment of diabetes.
Background technology
Diabetes have become in world many countries commonly encountered diseases and the frequently-occurring disease that mortality rate is only second to cancer, acquired immune deficiency syndrome (AIDS) and cardiovascular disease, and China about has 100,000,000 diabeticss nearly at present, is the second in the world diabetes big countries.
Comparatively commonly type ii diabetes clinically, be called non-insulin-dependent diabetes mellitus, type ii diabetes is also Adult Onset's patients with type Ⅰ DM in the past, how the sequela of 35 ~ 40 years old, onset is slow, concealment, and some patients finds in physical examination or when checking other diseases.The ability producing insulin in type ii diabetes ward mate body not completely loses, and in some patient bodies, insulin even produces too much, but the action effect of insulin is had a greatly reduced quality, and the insulin therefore in patient body is a kind of shortage relatively.The secretion of insulin in body can be stimulated by some oral drugs.But still have some patients to need to carry out insulinize as type 1 diabetes to the later stage.
The main purpose for the treatment of diabetes comprises: correct metabolism disorder, eliminates symptom, safeguards the ability of good live and work; Prevent various acute or chronic complicating diseases and the generation with disease, life-saving, reduce disability rate and case fatality rate.The treatment of diabetes not only comprises the control of hyperglycemia, still needs and takes Comprehensive Treatment for some complication (as hypertension, lipid metabolic disorder etc.) and various complication etc. simultaneously.The complication of type ii diabetes comprises diabetic nephropathy, diabetic peripheral vasculopathy, diabetic peripheral neuropathy, diabetic cardiopathy etc.
The medicine of western medical treatment diabetes is a lot, as sulphanylureas, biguanides, diabetes pill etc., though these medicines can control the decline of blood glucose target, but these are mostly chemical drugs or contain chemical drugs, easily cause gastrointestinal reaction as abdominal distention, stomachache, diarrhoea, crampy gastrointestinal pain, obstipation etc., also have borborygmus, Nausea and vomiting, loss of appetite etc., hypoglycemic reaction also can occur sometimes, and by renal excretion, long-term taking has certain infringement to human body.
TCM Treatment of Diabetes foot possesses unique advantage and feature, long history and significant curative effect is had in treatment diabetes and complication thereof, the deficiency of doctor trained in Western medicine can be made up, but existing Chinese medicine also can not meet clinical needs far away, on the one hand, effect is obvious not, on the other hand, take effect slower, so find effective drug regimen to obtain more excellent formula from Chinese herbal medicine, tool has very important significance.
Summary of the invention
The technical problem that the present invention solves is to provide that a kind of drug effect is definite, the Chinese medicine preparation of the treatment diabetes of instant effect.
Technical scheme of the present invention is:
Treating a Chinese medicine preparation for diabetes, is be prepared from according to following technique by the major ingredient of following weight portion and adjuvant:
Major ingredient: Radix Astragali 10 ~ 30 Fen, Cortex araliae chinensis 9 ~ 15 parts, Resina persicae 18 ~ 30 parts, pilea mongolica 20 ~ 40 parts, Herba nepenthis 25 ~ 45 parts, 12 ~ 20 parts, sweet banyan wood, Herba Ranunculi Chinensis 0.8 ~ 1.2 part, Armillaria mellea 24 ~ 60 parts, Flos Viciae fabae 15 ~ 45 parts, the Fructus Sophorae 4 ~ 10 parts, Dioscorea nipponica Mak. Ningpo Yam Rhizome 6 ~ 15 parts;
Adjuvant: curcumol extract 0.25 ~ 0.35 part, SAM 0.01 ~ 0.03 part, glutathion 0.008 ~ 0.012 part, antioxidant 0.03 ~ 0.06 part, excipient 0.6 ~ 0.9 part, sweeting agent 1.2 ~ 3.0 parts;
Preparation technology:
(1) above-mentioned major ingredient is got by proportioning, clean up respectively, dry, be ground into coarse powder, obtain the coarse powder of each medical material, the water being equivalent to all medicinal material coarse powder gross weights 10 ~ 14 times of weight is added in boiler, first fennel fennel Bulbus Allii coarse powder is put into boiler, after big fire is boiled, change little fire to decoct 1 ~ 2 hour, and then add remaining medicinal material coarse powder, continue to decoct extraction 1 ~ 1.5 hour, filter, obtain first-time filtrate and a filtering residue, filtering residue continues to add and again decocts extraction 0.5 ~ 1.0 hour relative to filtering residue 4 ~ 8 times of water gagings, again filter and obtain secondary filtrate and secondary filtering residue, merged twice filtrate and twice filtering residue respectively, stand-by,
(2) filtrate that step (1) finally obtains is removed impurity with alcohol deposition method, reclaim ethanol, obtain pure Chinese medicine extraction liquid, filtering residue after merging is pulverized, obtain filtering residue powder, again described filtering residue powder is mixed with described pure Chinese medicine extraction liquid, be prepared into micro-powder of Chinese herbs by micronization technology;
(3) get above-mentioned adjuvant by proportioning, the micro-powder of Chinese herbs obtained with step (2) mixes, and according to the requirement of pharmacy customary adjuvant, is prepared into pharmaceutically acceptable dosage form, namely obtains a kind of Chinese medicine preparation for the treatment of diabetes of the present invention.Described pharmacy customary adjuvant comprises microcrystalline Cellulose, magnesium stearate, carboxymethyl starch sodium, sodium benzoate etc.
Further, described antioxidant is selected from vitamin E, vitamin C, isoflavone, zinc, selenium, ebselen, and carotenoid, any one or any two kinds and above combination in alpha-lipoic acid, preferred alpha-lipoic acid, alpha-lipoic acid enters cell in vivo after intestinal absorption, have fat-soluble and water miscible characteristic concurrently, therefore can go everywhere without any hindrance here at whole body, arrive any one cell area, thering is provided human body comprehensive usefulness, is the fat-soluble and water miscible universal antioxidant of tool.
Further, described excipient is arabic gum.Arabic gum is safe and harmless, effective.
Further, described sweeting agent is vinegar sultone potassium.Vinegar sultone potassium is the one of generation sugar such as glucide (Saccharin), aspartame (Aspartame) (artificial sweetening agent).Its sugariness is about 1 hundred to two hundred times of Caulis Sacchari sinensis, does not have heat.Its advantage is to thermally-stabilised, can not destroy because of heating, and shortcoming is then slightly bitterness.Therefore it has become perfect match with aspartame, and both are used in combination, can improve the unstability of aspartame to heat, also can eliminate the bitterness of vinegar sultone potassium (ACE ~ K) on the other hand.
Further, in described preparation technology, step (2) described alcohol deposition method ethanol used is dehydrated alcohol.
Further, in described preparation technology, step (2) described micronization technology specifically refers to high pressure homogenization method, concrete operations are: be 1: 24 ~ 28 to mix described filtering residue powder and described pure Chinese medicine extraction liquid, with high pressure homogenizer, under the pressure condition of 115 ~ 125MPa according to solid-liquid ratio, circulation homogenizing 3 times, obtain micropowder suspension, dry, obtain micro-powder of Chinese herbs.Release and the curative effect of medicine can be strengthened after drug micronization, greatly improve bioavailability.
Further, in described preparation technology, described in step (3), pharmaceutically acceptable dosage form comprises: tablet, hard capsule, oral liquid, also can be other dosage forms.
The invention has the beneficial effects as follows: prescription is rigorous, compatibility is reasonable, and active constituent content is high, and drug effect is remarkable, and instant effect, is free from side effects, and safety is relieved.
Detailed description of the invention
Embodiment 1:
Treating a Chinese medicine preparation for diabetes, is be prepared from according to following technique by the major ingredient of following weight portion and adjuvant:
Major ingredient: Radix Astragali 10 Fen, Cortex araliae chinensis 9 parts, Resina persicae 18 parts, pilea mongolica 20 parts, Herba nepenthis 25 parts, 12 parts, sweet banyan wood, Herba Ranunculi Chinensis 0.8 part, Armillaria mellea 24 parts, Flos Viciae fabae 15 parts, the Fructus Sophorae 4 parts, Dioscorea nipponica Mak. Ningpo Yam Rhizome 6 parts;
Adjuvant: curcumol extract 0.25 part, SAM 0.01 part, glutathion 0.008 part, antioxidant 0.03 part, excipient 0.6 part, sweeting agent 1.2 parts;
Wherein, described antioxidant is selected from vitamin E, vitamin C, isoflavone, zinc, selenium, ebselen, and carotenoid, any one or any two kinds and above combination in alpha-lipoic acid, preferred alpha-lipoic acid, alpha-lipoic acid enters cell in vivo after intestinal absorption, have fat-soluble and water miscible characteristic concurrently, therefore can go everywhere without any hindrance here at whole body, arrive any one cell area, thering is provided human body comprehensive usefulness, is the fat-soluble and water miscible universal antioxidant of tool.
Wherein, described excipient is arabic gum.Arabic gum is safe and harmless, effective.
Wherein, described sweeting agent is vinegar sultone potassium.Vinegar sultone potassium is the one of generation sugar such as glucide (Saccharin), aspartame (Aspartame) (artificial sweetening agent).Its sugariness is about 1 hundred to two hundred times of Caulis Sacchari sinensis, does not have heat.Its advantage is to thermally-stabilised, can not destroy because of heating, and shortcoming is then slightly bitterness.Therefore it has become perfect match with aspartame, and both are used in combination, can improve the unstability of aspartame to heat, also can eliminate the bitterness of vinegar sultone potassium (ACE ~ K) on the other hand.
Preparation technology is:
(1) above-mentioned major ingredient is got by proportioning, clean up respectively, dry, be ground into coarse powder, obtain the coarse powder of each medical material, the water being equivalent to all medicinal material coarse powder gross weights 10 times of weight is added in boiler, first fennel fennel Bulbus Allii coarse powder is put into boiler, after big fire is boiled, change little fire to decoct 1 hour, and then add remaining medicinal material coarse powder, continue to decoct extraction 1 hour, filter, obtain first-time filtrate and a filtering residue, filtering residue continues to add and again decocts extraction 0.5 hour relative to filtering residue 4 times of water gagings, again filter and obtain secondary filtrate and secondary filtering residue, merged twice filtrate and twice filtering residue respectively, stand-by,
(2) filtrate that step (1) finally obtains is removed impurity with alcohol deposition method, ethanol used is dehydrated alcohol, reclaim ethanol, obtain pure Chinese medicine extraction liquid, filtering residue after merging is pulverized, obtain filtering residue powder, more described filtering residue powder is mixed with described pure Chinese medicine extraction liquid, be prepared into micro-powder of Chinese herbs by micronization technology.Described micronization technology specifically refers to high pressure homogenization method, and concrete operations are: be to mix described filtering residue powder and described pure Chinese medicine extraction liquid, with high pressure homogenizer at 1: 24 according to solid-liquid ratio, under the pressure condition of 115MPa, circulation homogenizing 3 times, obtains micropowder suspension, drying, obtains micro-powder of Chinese herbs.Release and the curative effect of medicine can be strengthened after drug micronization, greatly improve bioavailability.
(3) get above-mentioned adjuvant by proportioning, the micro-powder of Chinese herbs obtained with step (2) mixes, and adds 20 parts of microcrystalline Cellulose and 3 parts of carboxymethyl starch sodium, is prepared into tablet, namely obtains a kind of Chinese medicine preparation for the treatment of diabetes of the present invention.
Embodiment 2:
Treating a Chinese medicine preparation for diabetes, is be prepared from according to following technique by the major ingredient of following weight portion and adjuvant:
Major ingredient: Radix Astragali 2 Fen, Cortex araliae chinensis 12 parts, Resina persicae 24 parts, pilea mongolica 30 parts, Herba nepenthis 35 parts, 16 parts, sweet banyan wood, Herba Ranunculi Chinensis 1.0 parts, Armillaria mellea 42 parts, Flos Viciae fabae 30 parts, the Fructus Sophorae 7 parts, Dioscorea nipponica Mak. Ningpo Yam Rhizome 10.5 parts;
Adjuvant: curcumol extract 0.3 part, SAM 0.02 part, glutathion 0.01 part, antioxidant 0.045 part, excipient 0.75 part, sweeting agent 2.1 parts;
Wherein, described antioxidant is selected from vitamin E, vitamin C, isoflavone, zinc, selenium, ebselen, and carotenoid, any one or any two kinds and above combination in alpha-lipoic acid, preferred alpha-lipoic acid, alpha-lipoic acid enters cell in vivo after intestinal absorption, have fat-soluble and water miscible characteristic concurrently, therefore can go everywhere without any hindrance here at whole body, arrive any one cell area, thering is provided human body comprehensive usefulness, is the fat-soluble and water miscible universal antioxidant of tool.
Wherein, described excipient is arabic gum.Arabic gum is safe and harmless, effective.
Wherein, described sweeting agent is vinegar sultone potassium.Vinegar sultone potassium is the one of generation sugar such as glucide (Saccharin), aspartame (Aspartame) (artificial sweetening agent).Its sugariness is about 1 hundred to two hundred times of Caulis Sacchari sinensis, does not have heat.Its advantage is to thermally-stabilised, can not destroy because of heating, and shortcoming is then slightly bitterness.Therefore it has become perfect match with aspartame, and both are used in combination, can improve the unstability of aspartame to heat, also can eliminate the bitterness of vinegar sultone potassium (ACE ~ K) on the other hand.
Preparation technology is:
(1) above-mentioned major ingredient is got by proportioning, clean up respectively, dry, be ground into coarse powder, obtain the coarse powder of each medical material, the water being equivalent to all medicinal material coarse powder gross weights 12 times of weight is added in boiler, first fennel fennel Bulbus Allii coarse powder is put into boiler, after big fire is boiled, change little fire to decoct 1.5 hours, and then add remaining medicinal material coarse powder, continue to decoct extraction 1.25 hours, filter, obtain first-time filtrate and a filtering residue, filtering residue continues to add and again decocts extraction 0.75 hour relative to filtering residue 6 times of water gagings, again filter and obtain secondary filtrate and secondary filtering residue, merged twice filtrate and twice filtering residue respectively, stand-by,
(2) filtrate that step (1) finally obtains is removed impurity with alcohol deposition method, ethanol used is dehydrated alcohol, reclaim ethanol, obtain pure Chinese medicine extraction liquid, filtering residue after merging is pulverized, obtain filtering residue powder, more described filtering residue powder is mixed with described pure Chinese medicine extraction liquid, be prepared into micro-powder of Chinese herbs by micronization technology.Described micronization technology specifically refers to high pressure homogenization method, and concrete operations are: be to mix described filtering residue powder and described pure Chinese medicine extraction liquid, with high pressure homogenizer at 1: 26 according to solid-liquid ratio, under the pressure condition of 120MPa, circulation homogenizing 3 times, obtains micropowder suspension, drying, obtains micro-powder of Chinese herbs.Release and the curative effect of medicine can be strengthened after drug micronization, greatly improve bioavailability.
(3) get above-mentioned adjuvant by proportioning, the micro-powder of Chinese herbs obtained with step (2) mixes, and adds 22.5 parts of microcrystalline Cellulose and 0.55 part of magnesium stearate, is prepared into hard capsule, namely obtains a kind of Chinese medicine preparation for the treatment of diabetes of the present invention.
Embodiment 3:
Treating a Chinese medicine preparation for diabetes, is be prepared from according to following technique by the major ingredient of following weight portion and adjuvant:
Major ingredient: Radix Astragali 30 Fen, Cortex araliae chinensis 15 parts, Resina persicae 30 parts, pilea mongolica 40 parts, Herba nepenthis 45 parts, 20 parts, sweet banyan wood, Herba Ranunculi Chinensis 1.2 parts, Armillaria mellea 60 parts, Flos Viciae fabae 45 parts, the Fructus Sophorae 10 parts, Dioscorea nipponica Mak. Ningpo Yam Rhizome 15 parts;
Adjuvant: curcumol extract 0.35 part, SAM 0.03 part, glutathion 0.012 part, antioxidant 0.06 part, excipient 0.9 part, sweeting agent 3.0 parts;
Wherein, described antioxidant is selected from vitamin E, vitamin C, isoflavone, zinc, selenium, ebselen, and carotenoid, any one or any two kinds and above combination in alpha-lipoic acid, preferred alpha-lipoic acid, alpha-lipoic acid enters cell in vivo after intestinal absorption, have fat-soluble and water miscible characteristic concurrently, therefore can go everywhere without any hindrance here at whole body, arrive any one cell area, thering is provided human body comprehensive usefulness, is the fat-soluble and water miscible universal antioxidant of tool.
Wherein, described excipient is arabic gum.Arabic gum is safe and harmless, effective.
Wherein, described sweeting agent is vinegar sultone potassium.Vinegar sultone potassium is the one of generation sugar such as glucide (Saccharin), aspartame (Aspartame) (artificial sweetening agent).Its sugariness is about 1 hundred to two hundred times of Caulis Sacchari sinensis, does not have heat.Its advantage is to thermally-stabilised, can not destroy because of heating, and shortcoming is then slightly bitterness.Therefore it has become perfect match with aspartame, and both are used in combination, can improve the unstability of aspartame to heat, also can eliminate the bitterness of vinegar sultone potassium (ACE ~ K) on the other hand.
Preparation technology is:
(1) above-mentioned major ingredient is got by proportioning, clean up respectively, dry, be ground into coarse powder, obtain the coarse powder of each medical material, the water being equivalent to all medicinal material coarse powder gross weights 14 times of weight is added in boiler, first fennel fennel Bulbus Allii coarse powder is put into boiler, after big fire is boiled, change little fire to decoct 2 hours, and then add remaining medicinal material coarse powder, continue to decoct extraction 1.5 hours, filter, obtain first-time filtrate and a filtering residue, filtering residue continues to add and again decocts extraction 1.0 hours relative to filtering residue 8 times of water gagings, again filter and obtain secondary filtrate and secondary filtering residue, merged twice filtrate and twice filtering residue respectively, stand-by,
(2) filtrate that step (1) finally obtains is removed impurity with alcohol deposition method, ethanol used is dehydrated alcohol, reclaim ethanol, obtain pure Chinese medicine extraction liquid, filtering residue after merging is pulverized, obtain filtering residue powder, more described filtering residue powder is mixed with described pure Chinese medicine extraction liquid, be prepared into micro-powder of Chinese herbs by micronization technology.Described micronization technology specifically refers to high pressure homogenization method, and concrete operations are: be to mix described filtering residue powder and described pure Chinese medicine extraction liquid, with high pressure homogenizer at 1: 28 according to solid-liquid ratio, under the pressure condition of 125MPa, circulation homogenizing 3 times, obtains micropowder suspension, drying, obtains micro-powder of Chinese herbs.Release and the curative effect of medicine can be strengthened after drug micronization, greatly improve bioavailability.
(3) above-mentioned adjuvant is got by proportioning, the micro-powder of Chinese herbs obtained with step (2) mixes, and adds 25 parts of microcrystalline Cellulose, 0.2 part of sodium benzoate, adds purified water in full dose, be prepared into oral liquid, namely obtain a kind of Chinese medicine preparation for the treatment of diabetes of the present invention.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (7)
1. treat a Chinese medicine preparation for diabetes, it is characterized in that being prepared from according to following technique by the major ingredient of following weight portion and adjuvant:
Major ingredient: Radix Astragali 10 ~ 30 Fen, Cortex araliae chinensis 9 ~ 15 parts, Resina persicae 18 ~ 30 parts, pilea mongolica 20 ~ 40 parts, Herba nepenthis 25 ~ 45 parts, 12 ~ 20 parts, sweet banyan wood, Herba Ranunculi Chinensis 0.8 ~ 1.2 part, Armillaria mellea 24 ~ 60 parts, Flos Viciae fabae 15 ~ 45 parts, the Fructus Sophorae 4 ~ 10 parts, Dioscorea nipponica Mak. Ningpo Yam Rhizome 6 ~ 15 parts;
Adjuvant: curcumol extract 0.25 ~ 0.35 part, SAM 0.01 ~ 0.03 part, glutathion 0.008 ~ 0.012 part, antioxidant 0.03 ~ 0.06 part, excipient 0.6 ~ 0.9 part, sweeting agent 1.2 ~ 3.0 parts;
Preparation technology:
(1) above-mentioned major ingredient is got by proportioning, pulverize respectively, obtain the coarse powder of each medical material, the water being equivalent to all medicinal material coarse powder gross weights 10 ~ 14 times of weight is added in boiler, first fennel fennel Bulbus Allii coarse powder is put into boiler, decoct 1 ~ 2 hour, and then add remaining medicinal material coarse powder, continue to decoct extraction 1 ~ 1.5 hour, filter, obtain first-time filtrate and a filtering residue, filtering residue continues to add and again decocts extraction 0.5 ~ 1.0 hour relative to filtering residue 4 ~ 8 times of water gagings, again filter and obtain secondary filtrate and secondary filtering residue, merged twice filtrate and twice filtering residue respectively, stand-by,
(2) filtrate that step (1) finally obtains is removed impurity with alcohol deposition method, reclaim ethanol, obtain pure Chinese medicine extraction liquid, filtering residue after merging is pulverized, obtain filtering residue powder, again described filtering residue powder is mixed with described pure Chinese medicine extraction liquid, be prepared into micro-powder of Chinese herbs by micronization technology;
(3) get above-mentioned adjuvant by proportioning, the micro-powder of Chinese herbs obtained with step (2) mixes, and is prepared into pharmaceutically acceptable dosage form, namely obtains a kind of Chinese medicine preparation for the treatment of diabetes of the present invention.
2. a kind of Chinese medicine preparation for the treatment of diabetes according to claim 1, is characterized in that described antioxidant is selected from vitamin E, vitamin C, isoflavone, zinc, selenium, ebselen, and carotenoid, any one or any two kinds and above combination in alpha-lipoic acid.
3. a kind of Chinese medicine preparation for the treatment of diabetes according to claim 1, is characterized in that described excipient is arabic gum.
4. a kind of Chinese medicine preparation for the treatment of diabetes according to claim 1, is characterized in that described sweeting agent is vinegar sultone potassium.
5. a kind of Chinese medicine preparation for the treatment of diabetes according to claim 1, is characterized in that in described preparation technology, and step (2) described alcohol deposition method ethanol used is dehydrated alcohol.
6. a kind of Chinese medicine preparation for the treatment of diabetes according to claim 1, it is characterized in that in described preparation technology, step (2) described micronization technology specifically refers to high pressure homogenization method, concrete operations are: be 1: 24 ~ 28 to mix described filtering residue powder and described pure Chinese medicine extraction liquid, with high pressure homogenizer, under the pressure condition of 115 ~ 125MPa according to solid-liquid ratio, circulation homogenizing 3 times, obtain micropowder suspension, dry, obtain micro-powder of Chinese herbs.
7. a kind of Chinese medicine preparation for the treatment of diabetes according to claim 1, is characterized in that in described preparation technology, and described in step (3), pharmaceutically acceptable dosage form comprises: tablet, hard capsule, oral liquid.
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| CN1557402A (en) * | 2004-01-13 | 2004-12-29 | 吴琼汉 | Chinese herbal medicine preparation and its preparing process and application |
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Application publication date: 20150603 |