CN101829264B - Medicine composition for treating hyperuricemia and related diseases and preparation method and application thereof - Google Patents

Medicine composition for treating hyperuricemia and related diseases and preparation method and application thereof Download PDF

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CN101829264B
CN101829264B CN200910025326.9A CN200910025326A CN101829264B CN 101829264 B CN101829264 B CN 101829264B CN 200910025326 A CN200910025326 A CN 200910025326A CN 101829264 B CN101829264 B CN 101829264B
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alcohol
extraction
concentrated
water
extract
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CN101829264A (en
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萧伟
丁岗
曹亮
崔瑛
杨保林
李明慧
陈俊
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Jiangsu Kanion Pharmaceutical Co Ltd
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Jiangsu Kanion Pharmaceutical Co Ltd
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Abstract

The invention relates to a medicine composition for treating hyperuricemia and hyperuricemia related diseases (such as gout, urate nephropathy). The medicine composition is characterized by being prepared by adopting the following traditional Chinese medicine raw material according to the weight proportion: 0.1-15g of artemisia anomala, 0.1-15g of the bark of ash, 0.1-15g of thunberg fritillary bulb, 0.1-30g of wild chrysanthemum flower, 0-30g of astragalus root, 0-15g of cassia twig, 0-15g of kadsura pepper stem, 0-15g of herba lycopi and 0-15g of baical skullcap root. The invention discloses a preparation method, a preparation and application of the medicine composition. The invention has better safety, can effectively lower the concentration of uric acid and remarkably improve the symptoms of all stages of gout, and is suitable for treatment of hyperuricemia related diseases (such as gout, urate nephropathy), especially treatment of gout incubation (hyperuricemia) and diapause.

Description

Pharmaceutical composition and method for making and the purposes for the treatment of hyperuricemia and relevant disease
Technical field
The present invention relates to a kind of pharmaceutical composition that Chinese medicine is raw material of take, particularly a kind of treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy); The invention still further relates to preparation method, preparation and the purposes of this pharmaceutical composition.
Background technology
Gout (gout) is due to purine metabolic disturbance, and uric acid produces too much and/or underexcretion, and serum uric acid level continues to increase and causes urate crystal to be deposited on one group of metabolic disease due to joint and soft tissue.
Gout clinical manifestation can be divided into 4 stages: incubation period (hyperuricemia phase), acute stage, intermission, chronic phase.Asymptomatic stage only shows as hyperuricemia and without any symptom, by asymptomatic hyperuricemia, be developed to gout and generally experience the several years to many decades, but have, there is not throughout one's life gout yet, hyperuricemia (hyperuricemia) is the important biochemical basis of gout, but also easily involves kidney and cardiovascular system.Gout is repeatedly sent out author and is made progress gradually as the chronic arthritis phase, is more common in untreated or the not good patient for the treatment of, prevents that in early days the patient of hyperuricemia can be without this phase.Later stage can also cause nephropathy, shows as urate nephropathy, kidney urate calculus and acute renal failure.
The diseases such as hyperuricemia and primary gout and obesity, hyperlipemia, hypertension, diabetes, atherosclerosis are marked positive correlation, there are 60% patient with gout Complicated with Hypertension disease, coronary heart disease and hyperlipemia, the concurrent renal dysfunction of 30% patient.Therefore, gout is the same with diabetes, is a kind of serious metabolic disease of harm humans health.Find research determined curative effect, few or light medical treatment hyperuricemia and the gouty arthritis of untoward reaction has great importance.
Current China hyperuricemia sickness rate 10%, approximately 1.2 hundred million people.Gout sickness rate 1%, patient approximately 1,200 ten thousand.Modern medicine is to the treatment of gout still in the symptomatic treatment stage, and according to drug effect mode, chemical medicine can be divided into five classes: (1) suppresses granulocyte and infiltrates medicine, as colchicine; (2) suppress uricopoiesis medicine, as xanthine oxidase inhibitor allopurinol; (3) uricosureic agent, as probenecid, sulphinpyrazone, benzbromarone; (4) on-steroidal AID, as naproxen, indomethacin, Phenylbutazone or crovaril, piroxicam; (5) glucocorticoid, as prednisone.Wherein many kinds are the old medicine of last century five, sixties exploitation, and side effect is larger, and as medicine irritation, anaphylaxis, Liver and kidney toxicity, bone marrow depression etc., patient is difficult to continue application.Therefore the anti-gout drugs of finding high-efficiency low-toxicity from Chinese medicine is the focus of research always.
The traditional Chinese medical science is thought, gout is mainly due to surfeit Sorghum vulgare Pers. savoury usually, in turbid damp poison heresy, accumulate, affection of exogenous wind-cold, QI and blood is not smooth, in addition spleen kidney imbalance, wet, expectorant, the stasis of blood, the all evil numbness resistance passages through which vital energy circulates of heat form, therefore, the heat-clearing and toxic substances removing that adopt more, dampness removing is let out turbid, dispelling wind dredging collateral, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, the rule for the treatment of method for the treatment of of strengthening spleen, tonifying kidney, the Chinese patent medicine for the treatment of gout is still few at present, mainly contain numbness Medicine wine for activating the channels clearly, Fufangshenjin capsules, gout stator, gout relieving capsule and granule, TONGFENGDING capsule, Bin leaves of pulse plants Gout Mixture etc., still can not meet the demand sharply rising to can effectively reducing the gout Chinese patent medicine of blood uric acid in market, it is blank that gout is that the medicine of hyperuricemia still belongs to incubation period.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind for the treatment of hyperuricemia new, that compatibility is reasonable, curative effect is better and the pharmaceutical composition of associated disease.
Another technical problem to be solved by this invention has been to provide the preparation method of the pharmaceutical composition of multiple treatment hyperuricemia as above and associated disease.
Another technical problem to be solved by this invention has been to provide the pharmaceutical composition for the treatment of hyperuricemia as above and associated disease or the pharmaceutical preparation that preparation method as above is made.
Pharmaceutical composition of the present invention is applicable to hyperuricemia, and the disease relevant with hyperuricemia, as goat, urate nephropathy, is specially adapted to treat gout and hyperuricemia (gout incubation period, intermission).
Technical problem to be solved by this invention is to realize by following technical scheme.The present invention is a kind of pharmaceutical composition for the treatment of hyperuricemia and associated disease, is characterized in, it is to be made by the raw material of Chinese medicine of following weight proportion,
Herba Artemisiae Anomalae 0.1～15; Cortex Fraxini 0.1～15; Bulbus Fritillariae Thunbergii 0.1～15; Flos Chrysanthemi Indici 0.1～30;
The Radix Astragali 0～30; Ramulus Cinnamomi 0～15; Caulis Piperis Kadsurae 0～15; Herba Lycopi 0～15;
Radix Scutellariae 0～15.
In drug regimen composition formula of the present invention, Herba Artemisiae Anomalae, Cortex Fraxini, Bulbus Fritillariae Thunbergii and Flos Chrysanthemi Indici 4 taste raw materials form substantially square; The Radix Astragali, Ramulus Cinnamomi, Caulis Piperis Kadsurae, Herba Lycopi and Radix Scutellariae 5 taste raw materials are optional raw materials; Any in the optional raw material of 5 taste or multiplely can carry out prescription with the basic side of above-mentioned 4 tastes; When the weight proportion of the optional raw material of 5 taste is selected " 0 ", represent and in prescription, do not contain this raw material.
In above-described pharmaceutical composition, the preferred weight proportioning of each raw material is:
Herba Artemisiae Anomalae 6～9; Cortex Fraxini 6～9; Bulbus Fritillariae Thunbergii 3～9; Flos Chrysanthemi Indici 6～9;
The Radix Astragali 0～18; Ramulus Cinnamomi 0～9; Caulis Piperis Kadsurae 0～9; Herba Lycopi 0～9;
Radix Scutellariae 0～9.
In above-described pharmaceutical composition, when the basic side of any or multiple and above-mentioned 4 tastes in the Radix Astragali, Ramulus Cinnamomi, Caulis Piperis Kadsurae, Herba Lycopi and the optional raw material of Radix Scutellariae 5 taste carries out prescription, its weight proportion is preferably respectively; The Radix Astragali 0.1～30; Ramulus Cinnamomi 0.1～15; Caulis Piperis Kadsurae 0.1～15;
Herba Lycopi 0.1～15; Radix Scutellariae 0.1～15;
Further preferred weight proportion is respectively for the optional raw material of 5 taste:
The Radix Astragali 3～18; Ramulus Cinnamomi 0.1～6; Caulis Piperis Kadsurae 3～9;
Herba Lycopi 3～9; Radix Scutellariae 3～9.
In aforementioned pharmaceutical compositions, the preferred Artemisia anomah S. Moore of described Herba Artemisiae Anomalae (Artemisiaanomala), can be also siphonostegia chinensis (Siphonostegia chinensis).
Pharmaceutical composition of the present invention can be prepared according to conventional method of the prior art, extracts the active ingredient of each raw material of Chinese medicine, adds needed pharmaceutic adjuvant, makes the medicine of clinical any oral or exterior-applied formulation applicatory.Pharmaceutical composition of the present invention is preferably prepared by the method for the following stated.Drug combination preparation of the present invention or the preparation making by the inventive method can be the medicaments of acceptable any oral or exterior-applied formulation clinically, and its dosage form includes but not limited to capsule, soft capsule, tablet, pill, drop pill, granule, powder, patch, unguentum, gel, liquid preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can be prepared by the following method, and its step is as follows,
(1) get by weight ratio whole raw material of Chinese medicine and carry out decocting and obtain water extraction liquid, the concentrated water extracting liquid that to obtain; Or, water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) get water extracting liquid or water extract-alcohol precipitation concentrated solution, make oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution is dry, make oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, and its step is as follows,
(1) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes extraction volatile oil;
(2) medicinal residues obtain water extraction liquid, the concentrated water extracting liquid that to obtain with residue raw material of Chinese medicine merging decocting; Or, precipitate with ethanol after water extraction liquid is concentrated, precipitate with ethanol supernatant concentration obtains water extract-alcohol precipitation concentrated solution;
(3) get water extracting liquid or water extract-alcohol precipitation concentrated solution, add volatile oil, make oral or external preparation; Or water extracting liquid or water extract-alcohol precipitation concentrated solution is dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, its step is as follows, get by weight ratio whole raw material of Chinese medicine and carry out alcohol extraction, after alcohol extract is concentrated, make mixture or oral liquid, or concentratedly by dry, make oral or external preparation; Or, get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated, the alcohol extraction together of residue raw material of Chinese medicine, alcohol extract is concentrated, and alcohol extraction concentrated solution is merged, and make mixture or oral liquid, or drying is made oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, and its step is as follows,
(1) get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated;
(2) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated;
(3) alcohol extraction concentrated solution is merged, add volatile oil, make oral or external preparation; Or alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, and its step is as follows,
(1) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil;
(2) medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated, adds volatile oil, makes oral or external preparation; Or alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, and its step is as follows, gets by weight ratio whole raw material of Chinese medicine and carries out alcohol extraction, and alcohol extract is concentrated; Medicinal residues decocting, water extraction liquid is concentrated; Above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation; Or, alcohol extraction concentrated solution, water extracting liquid are dried, make oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, and its step is as follows,
(1) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil;
(2) medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract reclaims ethanol, obtains alcohol extract;
(3) medicinal residues decocting, water extraction liquid is concentrated, merges with alcohol extract, adds volatile oil, makes oral or external preparation; Or water extraction liquid is concentrated, merge with alcohol extract, dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, and its step is as follows,
(1) get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated;
(2) residue raw material of Chinese medicine alcohol extraction together, alcohol extract is concentrated;
(3) medicinal residues after above-mentioned alcohol extraction are merged to water extraction, water extraction liquid is concentrated;
(4) alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation; Or, alcohol extraction concentrated solution, water extracting liquid are dried, make oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, and its step is as follows,
(1) get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated;
(2) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated;
(3) medicinal residues after above-mentioned alcohol extraction are merged to water extraction, water extraction liquid is concentrated;
(4) alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, make oral or external preparation; Or alcohol extraction concentrated solution, water extracting liquid is dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, and its step is as follows,
(1) get by weight ratio Radix Astragali water extraction and obtain water extraction liquid, concentrate to obtain water extracting liquid; Or, get water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated;
(3) water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation; Or water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, and its step is as follows,
(1) get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Or water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated;
(3) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated;
(4) above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation; Or water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, and its step is as follows,
(1) get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Or water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) residue raw material of Chinese medicine alcohol extraction, alcohol extract is concentrated;
(3) water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, make oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, and its step is as follows,
(1) get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Or water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated;
(3) residue raw material of Chinese medicine merges alcohol extraction, and alcohol extract is concentrated;
(4) above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, make oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, gets by weight ratio whole raw material of Chinese medicine and pulverizes, and makes oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, and its step is as follows,
(1) get by weight ratio Bulbus Fritillariae Thunbergii 1 taste or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 tastes;
(2) residue raw material of Chinese medicine alcohol extraction together, after alcohol extract is concentrated and Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mix, drying is made oral or external preparation; Or, get residue Bulbus Fritillariae Thunbergii alcohol extraction, alcohol extract is concentrated, the alcohol extraction together of residue raw material of Chinese medicine, alcohol extract is concentrated, and alcohol extraction concentrated solution is merged, and mixes with Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder, and drying is made oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, and its step is as follows,
(1) get by weight ratio Bulbus Fritillariae Thunbergii 1 taste or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 tastes; Residue raw material of Chinese medicine carries out decocting and obtains water extraction liquid; Or precipitate with ethanol after water intaking extract is concentrated, obtains precipitate with ethanol supernatant;
(2) after water extraction liquid or precipitate with ethanol supernatant concentration, mix with Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder, drying is made oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, and its step is following (in this technical scheme, when raw material Bulbus Fritillariae Thunbergii is all beaten powder, without the operation of carrying out step (3); When the raw material Radix Astragali is all beaten powder, or while there is no the Radix Astragali in raw material, without the operation of carrying out step (2); In last preparation step (5), just do not add extract correspondingly yet),
(1) get by weight ratio Bulbus Fritillariae Thunbergii 1 taste or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 tastes;
(2) get residue Radix Astragali water extraction, water extraction liquid is concentrated; Or water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(3) get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract is concentrated;
(4) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated;
(5) water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder are mixed, dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
The pharmaceutical composition for the treatment of hyperuricemia of the present invention and associated disease can also be prepared by the following method, and its step is following (in this technical scheme, when raw material Bulbus Fritillariae Thunbergii is all beaten powder, without the operation of carrying out step (2); In last preparation step (4), just do not add extract correspondingly yet),
(1) get by weight ratio Bulbus Fritillariae Thunbergii 1 taste or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 tastes;
(2) get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract is concentrated;
(3) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated;
(4) above-mentioned alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder are mixed, dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
It is below the drug action experiment that inventor does.
One, Experimental agents:
1, G1: prescription is, Herba Artemisiae Anomalae, Cortex Fraxini, Flos Chrysanthemi Indici, Bulbus Fritillariae Thunbergii, weight proportion is 1: 1: 1: 1;
2, G2: prescription is, Herba Artemisiae Anomalae, Cortex Fraxini, Flos Chrysanthemi Indici, Bulbus Fritillariae Thunbergii, the Radix Astragali, weight proportion is 1: 1: 1: 1: 2;
3, G3: prescription is, Herba Artemisiae Anomalae, Cortex Fraxini, Flos Chrysanthemi Indici, Bulbus Fritillariae Thunbergii, the Radix Astragali, Ramulus Cinnamomi, weight proportion is 9: 9: 15: 3: 15: 1;
4, G4: prescription is, Herba Artemisiae Anomalae, Cortex Fraxini, Flos Chrysanthemi Indici, Bulbus Fritillariae Thunbergii, the Radix Astragali, Ramulus Cinnamomi, Caulis Piperis Kadsurae, Radix Scutellariae, Herba Lycopi, weight proportion is 9: 9: 15: 3: 15: 1: 6: 3: 6.
Two, experimentation and result.
1, the effect of G1 gout hyperuricemia research.
1.1G1 causes the impact of Studies on Animal Models of Hyperuricemic Mice on hypoxanthine.
Get 60 of ICR mices, female half and half, body weight 18～22g.The equal sub-cage rearing of mice, freely drinks water, and raises with laboratory animal mixed feed, keeps 20～25 ℃ of room temperatures, humidity 40～70%.
Get ICR mice, be divided at random 6 groups, 10 every group.Be respectively: blank group, model control group, the large, medium and small dosage group of G1 and positive controls.Wherein G1 little, in, heavy dose organizes the medicine normal saline suspension that gavage respectively gives (4,8,16g crude drug/kg), positive controls gives the allopurinol physiological salt liquid of 39mg/kg, and blank group and model control group give isometric normal saline.Once a day, be total to administration 5 days.1h after last administration respectively organizes mouse peritoneal injection hypoxanthine 1g/kg except blank group, blank group injection equal solvent normal saline.1h after injection hypoxanthine, each is organized mouse orbit and gets blood, and conventional separation of serum is measured uric acid in serum level, and result adopts the one factor analysis of variance of SPSS 13.0 to add up.The results are shown in Table 1.
Table 1G1 causes the impact (x ± s) of Studies on Animal Models of Hyperuricemic Mice on hypoxanthine
*expression is compared P < 0.01 with blank group, △ △p < 0.01 is compared in expression with model group
Result shows: compare with blank group, model group mice serum uric acid content obviously raises (P < 0.01), and modeling success is described.And G1 is large, medium and small compares the reduction (P < 0.01) all having in various degree in model group with positive controls mice serum uric acid content, and along with the increase of dosage, present certain dose-effect relationship.Showing that G1 has can reduce the effect that hypoxanthine induced mice uric acid increases.
1.2G1 causes the impact of mice metabolic arthritis model on Oteracil Potassium.
Get 60 of ICR mices, female half and half, the equal sub-cage rearing of mice, freely drinks water, and raises with laboratory animal mixed feed, keeps 20～25 ℃ of room temperatures, humidity 40～70%.
Get ICR mice and be divided at random 6 groups, be respectively: blank group, model control group, the large, medium and small dosage group of G1 and positive controls.Wherein G1 little, in, heavy dose organizes the medicine normal saline suspension that gavage respectively gives (4,8,16g crude drug/kg), positive controls gives the benzene of 6.5mg/kg and smells the grand physiological salt liquid of agate, and blank group and model control group give isometric normal saline.Once a day, be total to administration 5 days.1h after last administration respectively organizes mouse peritoneal injection Oteracil Potassium 300mg/kg except blank group, and blank group is injected isometric normal saline.1h after injection Oteracil Potassium, each is organized mouse orbit and gets blood, and conventional separation of serum is measured uric acid in serum level, relatively each group difference.Continuous data all adopts the one factor analysis of variance of SPSS 13.0.The results are shown in Table 2.
Table 2G1 causes the impact (x ± s) of Studies on Animal Models of Hyperuricemic Mice on Oteracil Potassium
*expression is compared P < 0.01 with blank group, and △ represents to compare with model group P < 0.05, and △ △ represents to compare with model group P < 0.01
Result shows: compare with blank group, model group mice serum uric acid content significantly raises (P < 0.01), shows modeling success.Compare with model group, positive controls and G1 group mice serum uric acid content significantly reduces (P < 0.01), G1 is little, in, heavy dose of group serum uric acid has and extremely significantly reduces (P < 0.01).Showing that G1 has can suppress Oteracil Potassium and cause the effect that mice uric acid increases.
2, the effect of G1～G4 gout hyperuricemia research.
2.1G1～G4 causes the impact of Studies on Animal Models of Hyperuricemic Mice on hypoxanthine.
Get 70 of ICR mices, female half and half, body weight 18～22g.The equal sub-cage rearing of mice, freely drinks water, and raises with laboratory animal mixed feed, keeps 20～25 ℃ of room temperatures, humidity 40～70%.
Get ICR mice, be divided at random 7 groups, male and female half and half, 10 every group.Be respectively: blank group, model control group, G1 group, G2 group, G3 group, G4 group and positive controls.Wherein G1～4 group respectively gavage give the medicine normal saline suspension of (8,12,13.2,16.8g crude drug/kg), positive controls gives the allopurinol physiological salt liquid of 39mg/kg, model control group gives isometric normal saline.Once a day, be total to administration 5 days.1h after last administration respectively organizes mouse peritoneal injection hypoxanthine 1g/kg except blank group, and blank group mouse peritoneal is injected isometric normal saline.1h after injection hypoxanthine, each is organized mouse orbit and gets blood, and conventional separation of serum is measured uric acid in serum level, and result adopts the one factor analysis of variance of SPSS 13.0 to add up.The results are shown in Table 3.
Table 3G1～G4 causes the impact (x ± s) of Studies on Animal Models of Hyperuricemic Mice on hypoxanthine
*expression is compared P < 0.01 with blank group, and △ △ represents to compare with model group P < 0.01
Result shows: compare with blank group, model group mice serum uric acid content obviously raises (P < 0.01), and modeling success is described.Comparing positive controls and each treatment group mice serum uric acid content with model group all has extremely significantly reduction (P < 0.01), and reduces the most obvious with G4 group.Illustrate that medicine G1～G4 group all has the hypoxanthine of inhibition and causes the effect that mice uric acid increases.
2.2G1～G4 causes the impact of mice metabolic arthritis model on Oteracil Potassium.
Get 60 of ICR mices, female half and half, body weight 18～22g.The equal sub-cage rearing of mice, freely drinks water, and raises with laboratory animal mixed feed, keeps 20～25 ℃ of room temperatures, humidity 40～70%.
Get ICR mice, be divided at random 7 groups, male and female half and half, 10 every group.Be respectively: blank group, model control group, G1 group, G2 group, G3 group, G4 group and positive controls.Wherein G1～G4 organizes the medicine normal saline suspension that gavage respectively gives (8g, 12,13.2,16.8g crude drug/kg), and positive controls gives the benzbromarone physiological salt liquid of 6.5mg/kg, and model control group gives isometric normal saline.Once a day, be total to administration 5 days.1h after last administration, each organizes mouse peritoneal injection Oteracil Potassium 300mg/kg, 1h after injection Oteracil Potassium, each is organized mouse orbit and gets blood, and conventional separation of serum is measured uric acid in serum level, and data all adopt the one factor analysis of variance of SPSS 13.0 to add up.The results are shown in Table 4.
Table 4G1～G4 causes the impact (x ± s) of Studies on Animal Models of Hyperuricemic Mice on Oteracil Potassium
*expression is compared P < 0.01 with blank group, and △ △ represents to compare with model group P < 0.01
Result shows: compare with blank group, model group mice serum uric acid content obviously raises (P < 0.01), and modeling success is described.Compare positive controls and each treatment group mice serum uric acid content with model group and all have extremely significantly reduction (P < 0.01).Illustrate that medicine G1～G4 group all has inhibition time Oteracil Potassium and causes the effect that mice uric acid increases.
The impact of 2.3G1～G4 on rat hyperuricemia model.
Get 70 of Wistar rats, female half and half, body weight 180～220g.The equal sub-cage rearing of rat, freely drinks water, and raises with laboratory animal mixed feed, keeps 20～25 ℃ of room temperatures, humidity 40～70%.
Get Wistar rat, be divided at random 7 groups, male and female half and half, 10 every group.Be respectively: blank group, model control group, G1 group, G2 group, G3 group, G4 group and positive controls.Except blank group, every group of oxonic acid+pyrazinamide suspension that the equal lumbar injection of rat is prepared with aquesterilisa, wherein contains oxonic acid 2g/100ml, contains pyrazinamide 1g/100ml.Injected dose is 1.5ml/100g body weight, administration every day 2 times.Blank group is injected isometric normal saline.All the other 5 groups give respectively G1, G2, G3, G4 (4.0,6.0,6.6,8.4g crude drug/kg) and positive control drug allopurinol 19.5mg/kg body weight, every day gastric infusion once, in last administration after one hour every group every rat eye socket get blood, conventional separation of serum, measure uric acid in serum (UA) and xanthine oxidase (XOD) content, data acquisition is added up with the one factor analysis of variance of SPSS13.0.The results are shown in Table 5.
The impact (x ± s) of table 5G1～G4 on rat hyperuricemia model serum UA content and XOD level
*expression is compared P < 0.01 with blank group, and △ represents to compare with model group P < 0.05, and △ △ represents to compare with model group P < 0.01
Result shows: model group rat blood serum UA compares with blank group and all has utmost point significant difference (P < 0.01) with XOD, and modeling success is described.For serum UA, compare each treatment group with model group and all can reduce in various degree its content, wherein positive controls and each administration group have significant difference (P < 0.01).Illustrate that medicine G1～G4 has the effect that this rat metabolic arthritis model serum uric acid increases that suppresses, the mechanism that medicine plays a role may be to realize by reducing the activity of XOD.
3, G1～G4 antiinflammatory action research.
3.1G1～G4 Dichlorodiphenyl Acetate causes the impact that mouse peritoneal capillary permeability increases.
Get 60 of ICR mices, male, body weight 18～22g.The equal sub-cage rearing of mice, freely drinks water, and raises with laboratory animal mixed feed, keeps 20～25 ℃ of room temperatures, humidity 40～70%.
Get ICR mice, adaptability is fed after three days and is started to test.Be divided at random 6 groups, 10 every group.Be respectively: model control group, G1～G4 group and positive controls.Wherein G1 group, G2 group, G3 group, G4 organize gavage respectively and give four kinds of medicines (8g, 12,13.2,16.8g crude drug/kg) normal saline suspension, positive controls gavage gives acetysalicylic physiological salt liquid 0.4g/kg, and model control group gives isometric normal saline.Administration every day 1 time, successive administration 5 days.30min after last administration, each organizes mouse mainline 0.5% azovan blue normal saline solution 0.1ml/10g, lumbar injection 0.6% acetic acid 0.2ml/ only immediately, after 20min, put to death, with 5ml normal saline, wash abdominal cavity immediately, sucking-off cleaning mixture, 3000 leave heart 15min, get one times of supernatant dilution, in each sample cell absorbance of 590nm colorimetric determination.Result adopts the one factor analysis of variance of SPSS13.0 to add up.The results are shown in Table 6.
The property impact (x ± s) that table 6G1～G4 is penetrating on mouse peritoneal blood capillary
△ represents to compare with model group P < 0.05, and △ △ represents to compare with model group P < 0.01
Result shows, each treatment group is compared OD value and is all decreased with model group, wherein G2, G3, G4 and positive controls reduce significantly (P < 0.01), and G1 group has significant difference (P < 0.05) equally.Illustrate that G1～G4 all has good antiinflammatory action.
3.2G1～G4 xylol causes the impact of mice auricle swelling
Get 60 of ICR mices, male, body weight 18～22g.The equal sub-cage rearing of mice, freely drinks water, and raises with laboratory animal mixed feed, keeps 20～25 ℃ of room temperatures, humidity 40～70%.
Get ICR mice, adaptability is fed after three days and is started to test.Be divided at random 6 groups, 10 every group.Be respectively: model control group, G1 group, G2 group, G3 group, G4 group and positive controls.Wherein G1 group, G2 group, G3 group, G4 organize the normal saline suspension that gavage respectively gives four kinds of medicines (8.0g, 12.0,13.2,16.8g crude drug/kg), positive controls gavage gives acetysalicylic physiological salt liquid 0.4g/kg, and model control group gives isometric normal saline.Administration every day 1 time, successive administration 3 days.The caused by dimethylbenzene xylene inflammation of 0.04ml is evenly smeared in last administration before and after every group of mouse right ear exterior feature after one hour, after causing scorching 45min, put to death mice, along auricle baseline, cut left and right two ears, with card punch (diameter 9mm), at same position, take off round auricle respectively, scales/electronic balance weighing, using the difference of mice left and right auricle weight as auricle swelling degree, and calculate swelling percentage rate.According to result of the test, carry out statistical analysis, the one factor analysis of variance statistics of SPSS13.0 for measurement data.The results are shown in Table 7.
Table 7G1～G4 xylol causes the impact (x ± s) of mice auricle swelling
* represent to compare with model control group P < 0.05, *p < 0.01 is compared in expression with model control group
Result shows: each administration group mice causes scorching rear ear swelling rate all reduction in various degree, G3, G4 group and positive controls are compared with model group has utmost point significant difference (P < 0.01), and G1, G2 group are compared with model group also significant difference (P < 0.05).Illustrate that G1～G4 all has good antiinflammatory action.
Inventor is by going deep into systematic study, and having filtered out can antalgic and inflammation relieving, can reduce again the Chinese medicine basic recipe of blood uric acid, by Herba Artemisiae Anomalae, Cortex Fraxini, Bulbus Fritillariae Thunbergii and Flos Chrysanthemi Indici 4 taste raw materials, forms substantially square; Also can select to add one or more raw materials in the Radix Astragali, Ramulus Cinnamomi, Caulis Piperis Kadsurae, Herba Lycopi and Radix Scutellariae 5 taste raw materials to carry out prescription.Compared with prior art, pharmaceutical composition of the present invention has good safety, can effectively reduce the concentration of blood uric acid, obviously alleviates each phase symptom of gout, be particularly useful for treating gout incubation period (hyperuricemia), intermission, filled up the blank of gout clinical medicine incubation period.
The specific embodiment
Below further describe concrete technical scheme of the present invention, so that those skilled in the art understands the present invention further, and do not form the restriction to its right.
Embodiment 1.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 30.Its method for making is: technique extracts the active ingredient of each raw material routinely, adds conventional adjuvant, makes oral or external preparation.
Embodiment 2.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 0.1; Cortex Fraxini 0.1; Bulbus Fritillariae Thunbergii 0.1; Flos Chrysanthemi Indici 0.1.Its method for making is: get by weight ratio whole raw material of Chinese medicine and carry out decocting and obtain water extraction liquid; After water extraction liquid is concentrated, make mixture or oral liquid.
Embodiment 3.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 9; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 15.Its method for making is: get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil; Medicinal residues merge decocting with residue raw material of Chinese medicine, obtain water extraction liquid; After water extraction liquid is concentrated, add volatile oil, make mixture or oral liquid.
Embodiment 4.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 12.Its method for making is: get by weight ratio whole raw material of Chinese medicine and carry out alcohol extraction, after alcohol extract is concentrated, make mixture or oral liquid.
Embodiment 5.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 15.Its method for making is: get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Alcohol extraction concentrated solution is merged, add volatile oil, make tablet.
Embodiment 6.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 5; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 10.Its method for making is: get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil; Medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated, adds volatile oil, makes capsule.
Embodiment 7.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 12; Cortex Fraxini 12; Bulbus Fritillariae Thunbergii 12; Flos Chrysanthemi Indici 5.Its method for making is: get by weight ratio whole raw material of Chinese medicine and carry out alcohol extraction, alcohol extract is concentrated; Medicinal residues decocting, water extraction liquid is concentrated; Above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation; Or, alcohol extraction concentrated solution, water extracting liquid are dried, make oral or external preparation.
Embodiment 8.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 14; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 18.Its method for making is: get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil; Medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract reclaims ethanol, obtains alcohol extract; Medicinal residues decocting, water extraction liquid is concentrated, merges with alcohol extract, adds volatile oil, makes oral or external preparation.
Embodiment 9.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 12; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 12; Flos Chrysanthemi Indici 23.Its method for making is: get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Medicinal residues after above-mentioned alcohol extraction are merged to water extraction, and water extraction liquid is concentrated; Alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, make oral or external preparation; Or alcohol extraction concentrated solution, water extracting liquid is dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 10.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 15.Its method for making is: get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract is concentrated; Medicinal residues after above-mentioned alcohol extraction are merged to water extraction, and water extraction liquid is concentrated; Alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation; Or, alcohol extraction concentrated solution, water extracting liquid are dried, make oral or external preparation.
Embodiment 11.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 8; Cortex Fraxini 7; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 10.Its method for making is: get by weight ratio whole raw material of Chinese medicine and pulverize, make oral or external preparation.
Embodiment 12.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 1; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 1; Flos Chrysanthemi Indici 30.Its recipe step is as follows: get by weight ratio all or part of powder of beating of Bulbus Fritillariae Thunbergii; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates afterwards and Bulbus Fritillariae Thunbergii powder mixes, and drying is made oral or external preparation; Or, get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract is concentrated, the alcohol extraction together of residue raw material of Chinese medicine, alcohol extract is concentrated, and alcohol extraction concentrated solution is merged, and mixes with Bulbus Fritillariae Thunbergii powder, and drying is made oral or external preparation.
Embodiment 13.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 1; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 1.Its recipe step is as follows: get by weight ratio all or part of powder of beating of Bulbus Fritillariae Thunbergii; Residue raw material of Chinese medicine carries out decocting and obtains water extraction liquid; Or precipitate with ethanol after water intaking extract is concentrated, obtains precipitate with ethanol supernatant; After water extraction liquid or precipitate with ethanol supernatant concentration, mix with Bulbus Fritillariae Thunbergii powder, drying is made oral or external preparation.
Embodiment 14.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 12; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 25.Its recipe step is as follows: get by weight ratio Bulbus Fritillariae Thunbergii and partly beat powder; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; By alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder mix, dry, after adding enclose or the volatile oil of enclose, does not make patch.
Embodiment 15.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 10.Its recipe step is as follows: get by weight ratio Bulbus Fritillariae Thunbergii and all beat powder; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; By above-mentioned alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder mix, dry, after adding enclose or the volatile oil of enclose, does not make powder.
Embodiment 16.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 1; Cortex Fraxini 1; Bulbus Fritillariae Thunbergii 1; Flos Chrysanthemi Indici 1; The Radix Astragali 2.Its recipe step is as follows: get by weight ratio Radix Astragali water extraction and obtain water extraction liquid, water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Residue raw material of Chinese medicine merges alcohol extraction, and alcohol extract is concentrated; Water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are dried, make oral or external preparation.
Embodiment 17.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 30; The Radix Astragali 30.Its recipe step is as follows: get by weight ratio Radix Astragali water extraction and obtain water extraction liquid, concentrate to obtain water extracting liquid; Or, get water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation; Or water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 18.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 9; The Radix Astragali 20.Its recipe step is as follows: get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Or water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation; Or water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 19.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 12; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 15; The Radix Astragali 10.Its recipe step is as follows: get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Or water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; The alcohol extraction of residue raw material of Chinese medicine, alcohol extract is concentrated; Water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, make gel.
Embodiment 20.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 14; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 28; The Radix Astragali 0.1.Its recipe step is as follows: get by weight ratio Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 tastes; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates afterwards and Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mix, and drying is made oral or external preparation; Or, get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract is concentrated, the alcohol extraction together of residue raw material of Chinese medicine, alcohol extract is concentrated, and alcohol extraction concentrated solution is merged, and mixes with Bulbus Fritillariae Thunbergii, astragalus membranaceus powder, and drying is made oral or external preparation.
Embodiment 21.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 7; Cortex Fraxini 11; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 23; The Radix Astragali 25.Its recipe step is as follows: get by weight ratio Bulbus Fritillariae Thunbergii, the Radix Astragali 2 tastes are all beaten powder; Residue raw material of Chinese medicine carries out decocting and obtains water extraction liquid; Or precipitate with ethanol after water intaking extract is concentrated, obtains precipitate with ethanol supernatant; After water extraction liquid or precipitate with ethanol supernatant concentration, mix the agent of drying granulation with Bulbus Fritillariae Thunbergii, astragalus membranaceus powder.
Embodiment 22.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 5; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 7; Flos Chrysanthemi Indici 10; Ramulus Cinnamomi 6.Its method for making is: get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil; Medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract reclaims ethanol, obtains alcohol extract; Medicinal residues decocting, water extraction liquid is concentrated, merges with alcohol extract, dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 23.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 12; Cortex Fraxini 8; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 20; Ramulus Cinnamomi 15.Its method for making is: get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract is concentrated; Medicinal residues after above-mentioned alcohol extraction are merged to water extraction, and water extraction liquid is concentrated; Alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation.
Embodiment 24.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 10; Flos Chrysanthemi Indici 15; Caulis Piperis Kadsurae 6.Its method for making is: get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Medicinal residues after above-mentioned alcohol extraction are merged to water extraction, and water extraction liquid is concentrated; Alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, make oral or external preparation.
Embodiment 25.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 25; Caulis Piperis Kadsurae 15.Its method for making is: get by weight ratio whole raw material of Chinese medicine and carry out alcohol extraction, alcohol extract is concentrated; Medicinal residues decocting, water extraction liquid is concentrated; Above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation; Or, alcohol extraction concentrated solution, water extracting liquid are dried, make oral or external preparation.
Embodiment 26.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 1; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 3; Herba Lycopi 6.Its method for making is: get by weight ratio whole raw material of Chinese medicine and carry out decocting and obtain water extraction liquid, the concentrated water extracting liquid that to obtain; Get water extracting liquid, make oral or external preparation; Or, water extracting liquid is dry, make oral or external preparation.
Embodiment 27.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 10; Flos Chrysanthemi Indici 15; Herba Lycopi 12.Its method for making is: get by weight ratio whole raw material of Chinese medicine and carry out decocting and obtain water extraction liquid, the concentrated water extracting liquid that to obtain; Water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get water extract-alcohol precipitation concentrated solution, make oral or external preparation; Or, water extract-alcohol precipitation concentrated solution is dry, make oral or external preparation.
Embodiment 28.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 8; Bulbus Fritillariae Thunbergii 9; Flos Chrysanthemi Indici 18; Radix Scutellariae 9.Its method for making is: get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil; Medicinal residues merge decocting with residue raw material of Chinese medicine and obtain water extraction liquid, concentrate to obtain water extracting liquid; Get water extracting liquid, add volatile oil, make oral or external preparation; Or water extracting liquid is dry, and after adding enclose or the volatile oil of enclose, does not make unguentum.
Embodiment 29.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 14; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 8; Radix Scutellariae 5.Its method for making is: get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil; Medicinal residues merge decocting with residue raw material of Chinese medicine and obtain water extraction liquid, concentrate to obtain water extracting liquid; Water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration obtains water extract-alcohol precipitation concentrated solution; Get water extract-alcohol precipitation concentrated solution, add volatile oil, make oral or external preparation; Or water extract-alcohol precipitation concentrated solution is dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 30.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 7; Cortex Fraxini 7; Bulbus Fritillariae Thunbergii 7; Flos Chrysanthemi Indici 7; The Radix Astragali 7; Ramulus Cinnamomi 7.Its method for making is: gets by weight ratio whole raw material of Chinese medicine and carries out decocting and obtain water extraction liquid, and precipitate with ethanol after water extraction liquid is concentrated, precipitate with ethanol supernatant is through concentrated mixture or the oral liquid made.
Embodiment 31.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 9; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 15; The Radix Astragali 15; Ramulus Cinnamomi 0.1.Its method for making is: get by weight ratio Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 tastes; Residue raw material of Chinese medicine carries out decocting and obtains water extraction liquid; Or precipitate with ethanol after water intaking extract is concentrated, obtains precipitate with ethanol supernatant; After water extraction liquid or precipitate with ethanol supernatant concentration, mix with Bulbus Fritillariae Thunbergii, astragalus membranaceus powder, drying is made oral or external preparation.
Embodiment 32.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 7; Cortex Fraxini 7; Bulbus Fritillariae Thunbergii 9; Flos Chrysanthemi Indici 8; The Radix Astragali 20; Ramulus Cinnamomi 1.Its method for making is: get by weight ratio Bulbus Fritillariae Thunbergii, the Radix Astragali 2 tastes are all beaten powder; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; By alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mix, dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 33.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 7; Cortex Fraxini 7; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 17; The Radix Astragali 5; Caulis Piperis Kadsurae 0.1.Its method for making is: its method for making is: get by weight ratio Bulbus Fritillariae Thunbergii, the Radix Astragali 2 tastes are partly beaten powder; Get residue Radix Astragali water extraction, water extraction liquid is concentrated; Or water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; By water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mix, dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 34.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 11; Cortex Fraxini 11; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 13; The Radix Astragali 25; Radix Scutellariae 3; Its method for making is: get by weight ratio Bulbus Fritillariae Thunbergii 1 taste or Bulbus Fritillariae Thunbergii, the Radix Astragali 2 tastes are all beaten powder; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; By above-mentioned alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mix, dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 35.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 20; The Radix Astragali 20; Herba Lycopi 6.Its method for making is: its method for making is: get by weight ratio Bulbus Fritillariae Thunbergii, the Radix Astragali 2 tastes are partly beaten powder; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; By above-mentioned alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mix, dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 36.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 10; Ramulus Cinnamomi 1; Caulis Piperis Kadsurae 15; Its method for making is: get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil; Medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated, adds volatile oil, makes oral or external preparation.
Embodiment 37.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 5; Cortex Fraxini 3; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 15; Ramulus Cinnamomi 8; Herba Lycopi 0.1; Its method for making is: get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract is concentrated; Medicinal residues after above-mentioned alcohol extraction are merged to water extraction, and water extraction liquid is concentrated; Alcohol extraction concentrated solution, water extracting liquid are dried, make oral or external preparation.
Embodiment 38.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 7; Flos Chrysanthemi Indici 10; Ramulus Cinnamomi 5; Radix Scutellariae 1; Its method for making is: get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Medicinal residues after above-mentioned alcohol extraction are merged to water extraction, and water extraction liquid is concentrated; Alcohol extraction concentrated solution, water extracting liquid is dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 39.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 8; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 10; Caulis Piperis Kadsurae 10; Herba Lycopi 10; Its method for making is: get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil; Medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract reclaims ethanol, obtains alcohol extract; Medicinal residues decocting, water extraction liquid is concentrated, merges with alcohol extract, adds volatile oil, makes oral or external preparation.
Embodiment 40.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 10; Caulis Piperis Kadsurae 8; Radix Scutellariae 6; Its method for making is: get by weight ratio Bulbus Fritillariae Thunbergii and all beat powder; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; By alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder mix, dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 41.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 20; Herba Lycopi 4; Radix Scutellariae 15; Get by weight ratio Bulbus Fritillariae Thunbergii and partly beat powder; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; By above-mentioned alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder mix, dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 42.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 15; The Radix Astragali 20; Ramulus Cinnamomi 5; Caulis Piperis Kadsurae 6; Its method for making is: get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; The alcohol extraction of residue raw material of Chinese medicine, alcohol extract is concentrated; Water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Or, water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are dried, make oral or external preparation.
Embodiment 43.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 9; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 30; The Radix Astragali 30; Ramulus Cinnamomi 3; Radix Scutellariae 0.1; Its method for making is: get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil; Medicinal residues merge decocting with residue raw material of Chinese medicine, obtain water extraction liquid; Precipitate with ethanol after water extraction liquid is concentrated, by precipitate with ethanol supernatant concentration, dry, after adding enclose or the volatile oil of enclose, does not make oral solid formulation.
Embodiment 44.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 12; Flos Chrysanthemi Indici 12; The Radix Astragali 15; Ramulus Cinnamomi 1; Herba Lycopi 6.Its method for making is: get by weight ratio Bulbus Fritillariae Thunbergii, the Radix Astragali 2 tastes are partly beaten powder; Get residue Radix Astragali water extraction, water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; By water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mix, dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 45.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 12; Cortex Fraxini 12; Bulbus Fritillariae Thunbergii 12; Flos Chrysanthemi Indici 12; Ramulus Cinnamomi 12; Caulis Piperis Kadsurae 12; Radix Scutellariae 12; Its method for making is: get by weight ratio Bulbus Fritillariae Thunbergii and all beat powder; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; By alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder mix, dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 46.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 9; Flos Chrysanthemi Indici 14; Ramulus Cinnamomi 8; Caulis Piperis Kadsurae 10; Herba Lycopi 10.Its method for making is: get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Alcohol extraction concentrated solution is merged, add volatile oil, make oral or external preparation; Or alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 47.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 9; Flos Chrysanthemi Indici 14; Caulis Piperis Kadsurae 10; Herba Lycopi 10; Radix Scutellariae 8; Its method for making is: get by weight ratio Bulbus Fritillariae Thunbergii and partly beat powder; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; By alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder mix, dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.。
Embodiment 48.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 30; Caulis Piperis Kadsurae 15; Herba Lycopi 15; The Radix Astragali 30; Its method for making is: get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation.
Embodiment 49.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 9; Flos Chrysanthemi Indici 14; Caulis Piperis Kadsurae 10; The Radix Astragali 10; Radix Scutellariae 8; Its method for making is: get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract is concentrated; Medicinal residues after above-mentioned alcohol extraction are merged to water extraction, and water extraction liquid is concentrated; Alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation.
Embodiment 50.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 9; Flos Chrysanthemi Indici 14; Ramulus Cinnamomi 10; Herba Lycopi 10; Radix Scutellariae 8; Its method for making is: get by weight ratio whole raw material of Chinese medicine and pulverize, make oral or external preparation.
Embodiment 51.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 12; Cortex Fraxini 12; Bulbus Fritillariae Thunbergii 4; Flos Chrysanthemi Indici 20; The Radix Astragali 15; Ramulus Cinnamomi 15; Caulis Piperis Kadsurae 15; Radix Scutellariae 9; Its method for making is: get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Water extracting liquid, alcohol extraction concentrated solution is dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 52.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 9; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 16; The Radix Astragali 16; Ramulus Cinnamomi 2; Caulis Piperis Kadsurae 9; Herba Lycopi 9.Its method for making is: get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Medicinal residues after above-mentioned alcohol extraction are merged to water extraction, and water extraction liquid is concentrated; Alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, make oral or external preparation; Or alcohol extraction concentrated solution, water extracting liquid is dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 53.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 8; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 18; The Radix Astragali 10; Ramulus Cinnamomi 5; Radix Scutellariae 6; Herba Lycopi 6.Its method for making is: get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Residue raw material of Chinese medicine merges alcohol extraction, and alcohol extract is concentrated; Above-mentioned water extracting liquid, alcohol extraction concentrated solution are merged, make oral or external preparation.
Embodiment 54.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 8; Bulbus Fritillariae Thunbergii 10; Flos Chrysanthemi Indici 6; The Radix Astragali 15; Caulis Piperis Kadsurae 6; Radix Scutellariae 6; Herba Lycopi 10.Its method for making is: get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Residue raw material of Chinese medicine merges alcohol extraction, and alcohol extract is concentrated; Above-mentioned water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Or, water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are dried, make oral or external preparation.
Embodiment 55.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 8; Bulbus Fritillariae Thunbergii 10; Flos Chrysanthemi Indici 6; Ramulus Cinnamomi 15; Caulis Piperis Kadsurae 6; Radix Scutellariae 6; Herba Lycopi 10.Its method for making is: get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 56.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 1; Cortex Fraxini 1; Bulbus Fritillariae Thunbergii 1; Flos Chrysanthemi Indici 1; The Radix Astragali 2; Ramulus Cinnamomi 1; Caulis Piperis Kadsurae 1; Radix Scutellariae 1; Herba Lycopi 1.Its method for making is: get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 57.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 0.5; Bulbus Fritillariae Thunbergii 0.5; Flos Chrysanthemi Indici 0.5; The Radix Astragali 0.5; Ramulus Cinnamomi 0.5; Caulis Piperis Kadsurae 0.5; Radix Scutellariae 15; Herba Lycopi 15.Its method for making is: get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Water extracting liquid, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation.
Embodiment 58.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 15; The Radix Astragali 15; Ramulus Cinnamomi 6; Caulis Piperis Kadsurae 9; Radix Scutellariae 9; Herba Lycopi 9.Its method for making is: get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Or water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Residue raw material of Chinese medicine merges alcohol extraction, and alcohol extract is concentrated; Above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, make oral or external preparation.
Embodiment 59.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 9; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 20; The Radix Astragali 20; Ramulus Cinnamomi 9; Caulis Piperis Kadsurae 6; Radix Scutellariae 6; Herba Lycopi 6.Its method for making is: get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Medicinal residues after above-mentioned alcohol extraction are merged to water extraction, and water extraction liquid is concentrated; Alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, make oral or external preparation; Or alcohol extraction concentrated solution, water extracting liquid is dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 60.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 8; Bulbus Fritillariae Thunbergii 10; Flos Chrysanthemi Indici 25; The Radix Astragali 30; Ramulus Cinnamomi 8; Caulis Piperis Kadsurae 10; Radix Scutellariae 10; Herba Lycopi 10.Its method for making is: get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Or water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation; Or water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, and after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 61.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 4; Flos Chrysanthemi Indici 10; The Radix Astragali 10; Ramulus Cinnamomi 5; Caulis Piperis Kadsurae 4; Radix Scutellariae 2; Herba Lycopi 5.Its method for making is, gets by weight ratio whole raw material of Chinese medicine and pulverizes, and makes oral or external preparation.
Embodiment 62.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 8; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 9; The Radix Astragali 18; Ramulus Cinnamomi 7; Caulis Piperis Kadsurae 6; Radix Scutellariae 5; Herba Lycopi 6.Its method for making is to get by weight ratio Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 tastes; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates afterwards and Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mix, and drying is made oral or external preparation; Or, get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract is concentrated, the alcohol extraction together of residue raw material of Chinese medicine, alcohol extract is concentrated, and alcohol extraction concentrated solution is merged, and mixes with Bulbus Fritillariae Thunbergii, astragalus membranaceus powder, and drying is made oral or external preparation.
Embodiment 63.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 15; The Radix Astragali 6; Ramulus Cinnamomi 9; Caulis Piperis Kadsurae 5; Radix Scutellariae 9; Herba Lycopi 7.Its method for making is to get by weight ratio Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 tastes; Residue raw material of Chinese medicine carries out decocting and obtains water extraction liquid; Or precipitate with ethanol after water intaking extract is concentrated, obtains precipitate with ethanol supernatant; After water extraction liquid or precipitate with ethanol supernatant concentration, mix with Bulbus Fritillariae Thunbergii, astragalus membranaceus powder, drying is made oral or external preparation.
Embodiment 64.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 7; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 9; Flos Chrysanthemi Indici 12; The Radix Astragali 9; Ramulus Cinnamomi 8; Caulis Piperis Kadsurae 7; Radix Scutellariae 8; Herba Lycopi 9.Its method for making is, gets by weight ratio Bulbus Fritillariae Thunbergii, the Radix Astragali 2 tastes are partly beaten powder; Get residue Radix Astragali water extraction, water extraction liquid is concentrated; Or water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; By water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mix, dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.
Embodiment 65.Treat hyperuricemia and with the pharmaceutical composition of hyperuricemia diseases related (as gout, urate nephropathy), it is to be made by the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 7.5; Cortex Fraxini 7.5; Bulbus Fritillariae Thunbergii 7.5; Flos Chrysanthemi Indici 7.5; The Radix Astragali 9; Ramulus Cinnamomi 7.5; Caulis Piperis Kadsurae 7.5; Radix Scutellariae 7.5; Herba Lycopi 7.5.Its method for making is, gets by weight ratio Bulbus Fritillariae Thunbergii, the Radix Astragali 2 tastes are partly beaten powder; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract is concentrated; Get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; By above-mentioned alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mix, dry, after adding enclose or the volatile oil of enclose, does not make oral or external preparation.

Claims (21)

1. oral treatment hyperuricemia and a pharmaceutical composition for associated disease, is characterized in that, it is to be made by the raw material of Chinese medicine of following weight proportion,
Herba Artemisiae Anomalae 6～9; Cortex Fraxini 6～9; Bulbus Fritillariae Thunbergii 3～9; Flos Chrysanthemi Indici 6～9; The Radix Astragali 0～18; Ramulus Cinnamomi 0～9; Caulis Piperis Kadsurae 0～9; Herba Lycopi 0～9; Radix Scutellariae 0～9.
2. a preparation method for the pharmaceutical composition for the treatment of hyperuricemia as claimed in claim 1 and associated disease, is characterized in that, its step is as follows,
(1) get by weight ratio whole raw material of Chinese medicine and carry out decocting and obtain water extraction liquid, the concentrated water extracting liquid that to obtain; Or, water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) get water extracting liquid or water extract-alcohol precipitation concentrated solution, make oral formulations; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution is dry, make oral formulations.
3. a preparation method for treatment hyperuricemia as claimed in claim 1 and associated disease medicament compositions, is characterized in that, its step is as follows:
(1) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes extraction volatile oil;
(2) medicinal residues obtain water extraction liquid, the concentrated water extracting liquid that to obtain with residue raw material of Chinese medicine merging decocting; Or, precipitate with ethanol after water extraction liquid is concentrated, precipitate with ethanol supernatant concentration obtains water extract-alcohol precipitation concentrated solution;
(3) get water extracting liquid or water extract-alcohol precipitation concentrated solution, add volatile oil, make oral formulations; Or water extracting liquid or water extract-alcohol precipitation concentrated solution is dry, and after adding enclose or the volatile oil of enclose, does not make oral formulations.
4. the preparation method of the pharmaceutical composition of a treatment hyperuricemia as claimed in claim 1 and associated disease, it is characterized in that, get by weight ratio whole raw material of Chinese medicine and carry out alcohol extraction, after alcohol extract is concentrated, make mixture or oral liquid, or concentrated by the dry oral formulations of making; Or, get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated, the alcohol extraction together of residue raw material of Chinese medicine, alcohol extract is concentrated, and alcohol extraction concentrated solution is merged, and make mixture or oral liquid, or drying is made oral formulations.
5. a preparation method for the pharmaceutical composition for the treatment of hyperuricemia as claimed in claim 1 and associated disease, is characterized in that, its step is as follows:
(1) get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated;
(2) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated;
(3) alcohol extraction concentrated solution is merged, add volatile oil, make oral formulations; Or alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of enclose, does not make oral formulations.
6. a preparation method for the pharmaceutical composition for the treatment of hyperuricemia as claimed in claim 1 and associated disease, is characterized in that, its step is as follows:
(1) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil;
(2) medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated, adds volatile oil, makes oral formulations; Or alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of enclose, does not make oral formulations.
7. a preparation method for the pharmaceutical composition for the treatment of hyperuricemia as claimed in claim 1 and associated disease, is characterized in that, gets by weight ratio whole raw material of Chinese medicine and carries out alcohol extraction, and alcohol extract is concentrated; Medicinal residues decocting, water extraction liquid is concentrated; Above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, make oral formulations; Or, alcohol extraction concentrated solution, water extracting liquid are dried, make oral formulations.
8. a preparation method for the pharmaceutical composition for the treatment of hyperuricemia as claimed in claim 1 and associated disease, is characterized in that, its step is as follows:
(1) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil;
(2) medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract reclaims ethanol, obtains alcohol extract;
(3) medicinal residues decocting, water extraction liquid is concentrated, merges with alcohol extract, adds volatile oil, makes oral formulations; Or water extraction liquid is concentrated, merge with alcohol extract, dry, after adding enclose or the volatile oil of enclose, does not make oral formulations.
9. a preparation method for the pharmaceutical composition for the treatment of hyperuricemia as claimed in claim 1 and associated disease, is characterized in that, its step is as follows:
(1) get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated;
(2) residue raw material of Chinese medicine alcohol extraction together, alcohol extract is concentrated;
(3) medicinal residues after above-mentioned alcohol extraction are merged to water extraction, water extraction liquid is concentrated;
(4) alcohol extraction concentrated solution, water extracting liquid are merged, make oral formulations; Or, alcohol extraction concentrated solution, water extracting liquid are dried, make oral formulations.
10. a preparation method for the pharmaceutical composition for the treatment of hyperuricemia as claimed in claim 1 and associated disease, is characterized in that, its step is as follows:
(1) get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated;
(2) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated;
(3) medicinal residues after above-mentioned alcohol extraction are merged to water extraction, water extraction liquid is concentrated;
(4) alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, make oral formulations; Or alcohol extraction concentrated solution, water extracting liquid is dry, and after adding enclose or the volatile oil of enclose, does not make oral formulations.
The preparation method of the pharmaceutical composition of 11. 1 kinds for the treatment of hyperuricemias as claimed in claim 1 and associated disease, is characterized in that, its step is as follows:
(1) get by weight ratio Radix Astragali water extraction and obtain water extraction liquid, concentrate to obtain water extracting liquid; Or, get water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated;
(3) water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral formulations; Or water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, and after adding enclose or the volatile oil of enclose, does not make oral formulations.
The preparation method of the pharmaceutical composition of 12. 1 kinds for the treatment of hyperuricemias as claimed in claim 1 and associated disease, is characterized in that, its step is as follows:
(1) get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Or water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated;
(3) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated;
(4) above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral formulations; Or water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, and after adding enclose or the volatile oil of enclose, does not make oral formulations.
The preparation method of the pharmaceutical composition of 13. 1 kinds for the treatment of hyperuricemias as claimed in claim 1 and associated disease, is characterized in that, its step is as follows:
(1) get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Or water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) residue raw material of Chinese medicine alcohol extraction, alcohol extract is concentrated;
(3) water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral formulations; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, make oral formulations.
The preparation method of the pharmaceutical composition of 14. 1 kinds for the treatment of hyperuricemias as claimed in claim 1 and associated disease, is characterized in that, its step is as follows:
(1) get by weight ratio Radix Astragali water extraction, water extraction liquid is concentrated; Or water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) get by weight ratio the independent alcohol extraction of Bulbus Fritillariae Thunbergii, alcohol extract is concentrated;
(3) residue raw material of Chinese medicine merges alcohol extraction, and alcohol extract is concentrated;
(4) above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral formulations; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, make oral formulations.
The preparation method of the pharmaceutical composition of 15. 1 kinds for the treatment of hyperuricemias as claimed in claim 1 and associated disease, is characterized in that, gets by weight ratio whole raw material of Chinese medicine and pulverizes, and makes oral formulations.
The preparation method of the pharmaceutical composition of 16. 1 kinds for the treatment of hyperuricemias as claimed in claim 1 and associated disease, its step is as follows:
(1) get by weight ratio Bulbus Fritillariae Thunbergii 1 taste or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 tastes;
(2) residue raw material of Chinese medicine alcohol extraction together, after alcohol extract is concentrated and Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mix, drying is made oral formulations; Or, get residue Bulbus Fritillariae Thunbergii alcohol extraction, alcohol extract is concentrated, the alcohol extraction together of residue raw material of Chinese medicine, alcohol extract is concentrated, and alcohol extraction concentrated solution is merged, and mixes with Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder, and drying is made oral formulations.
The preparation method of the pharmaceutical composition of 17. 1 kinds for the treatment of hyperuricemias as claimed in claim 1 and associated disease, its step is as follows:
(1) get by weight ratio Bulbus Fritillariae Thunbergii 1 taste or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 tastes; Residue raw material of Chinese medicine carries out decocting and obtains water extraction liquid; Or precipitate with ethanol after water intaking extract is concentrated, obtains precipitate with ethanol supernatant;
(2) after water extraction liquid or precipitate with ethanol supernatant concentration, mix with Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder, drying is made oral formulations.
The preparation method of the pharmaceutical composition of 18. 1 kinds for the treatment of hyperuricemias as claimed in claim 1 and associated disease, its step is as follows:
(1) get by weight ratio Bulbus Fritillariae Thunbergii 1 taste or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 tastes;
(2) get residue Radix Astragali water extraction, water extraction liquid is concentrated; Or water extraction liquid is concentrated, precipitate with ethanol, and precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(3) get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract is concentrated;
(4) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated;
(5) water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder are mixed, dry, after adding enclose or the volatile oil of enclose, does not make oral formulations.
The preparation method of the pharmaceutical composition of 19. 1 kinds for the treatment of hyperuricemias as claimed in claim 1 and associated disease, its step is as follows:
(1) get by weight ratio Bulbus Fritillariae Thunbergii 1 taste or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 tastes;
(2) get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract is concentrated;
(3) get by weight ratio Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 tastes or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 tastes or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 tastes extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated;
(4) above-mentioned alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder are mixed, dry, after adding enclose or the volatile oil of enclose, does not make oral formulations.
20. 1 kinds of pharmaceutical compositions as described in claim 1, is characterized in that, described oral pharmaceutical composition is capsule, tablet, pill, granule, powder, liquid preparation.
21. 1 kinds as described in claim 1 oral pharmaceutical composition as effective ingredient the purposes in preparation treatment hyperuricemia or gout or urate nephropathy medicine.
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