CN104645121A - Medicine for treating oral ulcer in children - Google Patents
Medicine for treating oral ulcer in children Download PDFInfo
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- CN104645121A CN104645121A CN201510115833.7A CN201510115833A CN104645121A CN 104645121 A CN104645121 A CN 104645121A CN 201510115833 A CN201510115833 A CN 201510115833A CN 104645121 A CN104645121 A CN 104645121A
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- spartina alterniflora
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Abstract
The invention discloses a medicine for treating oral ulcer in children. The medicine comprises an external medicine and an internal medicine, wherein the external medicine comprises an extract of spartina alterniflora; and the internal medicine comprises wheat germ, maize germ, endothelium corneum gigeriae galli, gastrodia elata, cortex phellodendri and ligusticum wallichii. Through comprehensive utilization of the internal medicine and the external medicine, the synergistic effect is generated; the external medicine is the extract of the spartina alterniflora, and is smeared on the ulcer surface; and the internal medicine has an obvious treatment effect on oral ulcer in children.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of Pediatric Oral Emergency ulcer.
Background technology
Oral ulcer is oral keritonocytes more common clinically, the serious life even affecting patient, speech and feed, and in crowd, sickness rate is up to about 20%, accounts for oral mucosal disease first place.When particularly child is recurred, easily cry and scream, its Clinical symptoms is periodical attack, and has self limiting, and companion's pain, mainly betides lip, cheek and lingual margin etc. without keratinization mucosa, how spontaneous recovery in 1 ~ 2 week, scarcely stay cicatrix more.General treatment by Chinese herbs effect is not fine, and comparatively pained, and child does not like taking.
Summary of the invention
For above-mentioned prior art Problems existing, the invention provides a kind of medicine for the treatment of Pediatric Oral Emergency ulcer, therapeutic effect is good, and has no side effect, and mouthfeel is better.
To achieve these goals, the technical solution used in the present invention is: a kind of medicine for the treatment of Pediatric Oral Emergency ulcer, comprises medicine for external use and oral medicine.
Described medicine for external use comprises: the extract of Spartina alterniflora.
Described oral medicine comprises: Fructus Tritici aestivi, Fructus Maydis, Herba Commelinae, Rhizoma Atractylodis, Cortex Phellodendri, Rhizoma Chuanxiong.
Described oral medicine comprises: 8-11 part Fructus Tritici aestivi, 7-11 part Fructus Maydis, 15-23 part Herba Commelinae, 17-20 part Rhizoma Atractylodis, 9-11 part Cortex Phellodendri, 8-11 part Rhizoma Chuanxiong.
The processing technology of the extract of described Spartina alterniflora is 1) by the Spartina alterniflora after vacuum drying, pulverize in pulverizer and obtain Spartina alterniflora's powder, Spartina alterniflora's powder is placed in the extraction kettle of supercritical extraction; 2) use supercritical CO 2 as solvent, concentration be 70% ~ 80% ethanol do entrainer; 3) regulate extraction kettle to control at 25 ~ 35MPa by extracting pressure, temperature controls at 40 ~ 50 DEG C, and CO2 flow-control is at 10 ~ 15L/h, and extraction time controls at 1 ~ 2h, obtains brown paste Spartina alterniflora total flavones.
Described oral medicine technique is:
(1) Fructus Tritici aestivi, Fructus Maydis, Herba Commelinae, Rhizoma Atractylodis, Cortex Phellodendri, Rhizoma Chuanxiong mixing are carried out Crushing of Ultrafine, and sieved with 10 object screen clothes, discard thick raw material and form raw material; Add water Homogeneous phase mixing carry out homogenizing by 20 MPa homogenizers, then carries out spraying dry, obtain powdered granule;
(2) above-mentioned powdered granule is added 18 parts of distillation hydro-thermals to 70-75 DEG C, the cellulase then adding 0.0007 part carries out enzymolysis, and in this process, temperature maintains 70-75 DEG C,
100 minutes persistent period, obtain enzymolysis solution; Rapid temperature increases to 100 DEG C also keeps 5 minutes, is then cooled to 65-70 DEG C rapidly, and carries out homogenizing by three homogenizers successively, then carry out spraying dry, finally obtain powdered granule.
The pressure of three described homogenizers is followed successively by 40 MPas, 65 MPas, 55 MPas.
The invention has the beneficial effects as follows: present invention comprises the problem that medicine for external use and oral medicine just solve Pediatric Oral Emergency ulcer.
In oral medicine production process, the oligosaccharide polysaccharide fine cellulose that the large peptide of little galanin peptide that Fructus Tritici aestivi, Fructus Maydis enzymolysis produce, the maltodextrin of 5%, starch, enzymolysis cellulose produce, emulsifying is abundant, and coated Herba Commelinae, Rhizoma Atractylodis, Cortex Phellodendri, Rhizoma Chuanxiong micropowder granule, diameter is at 15 microns, good being easy to of micro encapsulation effect absorbs, and absorbance also significantly improves, oligosaccharide, polysaccharide, the fine cellulose of energy; Significantly improve mouthfeel simultaneously.The application is by the comprehensive use of oral medicine and medicine for external use, and create collaborative effect, medicine for external use is the extract of Spartina alterniflora, spreads upon on ulcer surface, and oral oral medicine is to the dental ulcer treatment successful of child.
Detailed description of the invention
Example of the present invention can not limit the present invention to explanation of the present invention, and any change in the implication suitable with the present invention and scope and adjustment, all should think within the scope of the invention.
Embodiment 1
Comprise medicine for external use and oral medicine.
Described medicine for external use comprises: the extract of Spartina alterniflora.
The processing technology of the extract of described Spartina alterniflora is
1) by the Spartina alterniflora after vacuum drying, pulverize in pulverizer and obtain Spartina alterniflora's powder, Spartina alterniflora's powder is placed in the extraction kettle of supercritical extraction;
2) use supercritical CO 2 as solvent, concentration be 70% ethanol do entrainer; 3) regulate extraction kettle to control at 35MPa by extracting pressure, temperature controls at 0 DEG C, and CO2 flow-control is at 15L/h, and extraction time controls at 2h, obtains brown paste Spartina alterniflora total flavones.
Described oral medicine technique is:
(1) 8 portions of Fructus Tritici aestivis, 9 parts of Fructus Maydiss, 19 parts of Herba Commelinaes, 17 parts of Rhizoma Atractylodis, 11 parts of Cortex Phellodendris, 1 part of Rhizoma Chuanxiong mixing are carried out Crushing of Ultrafine, and sieved with 10 object screen clothes, discard thick raw material and form raw material; Add water Homogeneous phase mixing carry out homogenizing by 20 MPa homogenizers, then carries out spraying dry, obtain powdered granule;
(2) above-mentioned powdered granule is added 18 parts of distillation hydro-thermals to 70-75 DEG C, the cellulase then adding 0.0007 part carries out enzymolysis, and in this process, temperature maintains 70-75 DEG C,
100 minutes persistent period, obtain enzymolysis solution; Rapid temperature increases to 100 DEG C also keeps 5 minutes, is then cooled to 65-70 DEG C rapidly, and carries out homogenizing by three homogenizers successively, then carry out spraying dry, finally obtain powdered granule.
The pressure of three described homogenizers is followed successively by 40 MPas, 65 MPas, 55 MPas.
Comparative example 1: 8 portions of Fructus Tritici aestivis, 9 parts of Fructus Maydiss, 19 parts of Herba Commelinaes, 17 parts of Rhizoma Atractylodis, 11 parts of Cortex Phellodendris, 1 part of Rhizoma Chuanxiong are added water and decoct into medicinal liquid.
Comparative example 2: the processing technology of the extract of Spartina alterniflora is 1) by the Value of Spartina Anglica after vacuum drying, pulverize in pulverizer and obtain Value of Spartina Anglica powder, Value of Spartina Anglica powder is placed in the extraction kettle of supercritical extraction; 2) use supercritical CO 2 as solvent, concentration be 60% ~ 80% ethanol do entrainer; 3) regulate extraction kettle to control at 35MPa by extracting pressure, temperature controls at 50 DEG C, and CO2 flow-control is at 20L/h, and extraction time controls at 2h, obtains brown paste extract.
Comparative example 3: the processing technology of the extract of Spartina alterniflora is 1) by the Value of Spartina Anglica after vacuum drying, pulverize in pulverizer and obtain Value of Spartina Anglica powder, Value of Spartina Anglica powder is placed in the extraction kettle of supercritical extraction; 2) use supercritical CO 2 as solvent, concentration be 60% ~ 80% ethanol do entrainer; 3) regulate extraction kettle to control at 35MPa by extracting pressure, temperature controls at 50 DEG C, and CO2 flow-control is at 20L/h, and extraction time controls at 2h, obtains brown paste extract.
Comparative example 3: oral medicine: 11 portions of Fructus Tritici aestivis, 11 parts of Fructus Maydiss, 21 parts of Endothelium Corneum Gigeriae Galli, 18 parts of Rhizoma Gastrodiaes, 11 parts of Cortex Phellodendris, 9 parts of Rhizoma Chuanxiongs are added water and decoct into medicinal liquid, medicine for external use: the processing technology of the extract of Spartina alterniflora is 1) by the Value of Spartina Anglica after vacuum drying, pulverize in pulverizer and obtain Value of Spartina Anglica powder, Value of Spartina Anglica powder is placed in the extraction kettle of supercritical extraction; 2) use supercritical CO 2 as solvent, concentration be 60% ~ 80% ethanol do entrainer; 3) regulate extraction kettle to control at 35MPa by extracting pressure, temperature controls at 50 DEG C, and CO2 flow-control is at 20L/h, and extraction time controls at 2h, obtains brown paste extract.
Collect the 1-12 month in 2014 is diagnosed as recurrent oral ulceration 100 routine patients in section's outpatient service, in year mean age (27 ± 1.3), be divided into four groups at random; Often organize equal 25 people, four groups of patient ages, sex, the course of disease, clinical manifestation comparing difference not statistically significants (P>0.05), have comparability.
1.2 selected and exclusion standards
Inclusion criteria: disease time is less than the light-duty Blood of Patients with Recurrent Oral of 48 h.
Exclusion standard: heavy recurrent oral ulceration, Behcet disease; Systemic disease background; Traumatic ulcer, anemia, peptic ulcer, clone disease, acute infectious diseases, autoimmune disease etc.; Use analgesic in 24 h, use in 1 month antibiotic,
Antibiotic medicine, in 3 months, whole body uses corticosteroid, immunosuppressant.
Therapeutic Method
Embodiment 1: skin surface oral oral medicine simultaneously smeared by medicine for external use, every day 2 times,
Comparative example 1: oral every day 2 times.
Comparative example 2: smear skin surface every day 2 times.
Comparative example 3: skin surface oral oral medicine simultaneously smeared by medicine for external use, every day 2 times.
Four groups of patients can not take food in 30 min, drink water and gargle after coating.Treatments period does not use the other drug relevant to primary disease, does not eat pungent, peppery, dry food, notes sleep.
1.5 the standard of curative effect evaluation
According to Chinese stomatology meeting oral mucosal disease Professional Committee in May, 2001
Topical therapeutic therapeutic evaluation tentative standard (DP staging) in " the oral ulcer evaluation tentative standard " formulated.
1.5.1 the average ulcerative stage (d) of evaluation index (D): evaluate period each ulcer persistent period summation divided by ulcer sum; Pain index (dividing) (P): adopt Visual analogue scale (VAS) to record the pain scores of ulcerative stage every day.The implication of VAS is the line segment of employing 10 cm,
0 end represents " painless ", and 10 cm ends represent " the most violent pain ", and patient, according to the level of sensitivity of pain, keeps a record in the corresponding scale of straight line, 1 time/d.
1.5.2 evaluation criterion evaluation index classification, D1: average ulcerative stage shortens; D0:
Average ulcerative stage is without change; P1: pain index reduces; P0: pain index is without change.
Evaluation criterion, effective: D1P1; Effective: D1P0 or D0P1; Invalid: D0P0.
Effectively total=effective+effectively.
1.6 statistical procedures
The data obtained uses SPSS 13.0 to analyze, and enumeration data adopts x2-test, and the comparison U of sample average checks, and P<0.01 is that difference has statistical significance.
There is statistical significance (P<0.01).
Embodiment P<0.01 compared with three groups of comparative examples is that difference has statistical significance.
Average course of disease compares
Embodiment, average course of disease (3.1 ± 0.6) d,
Comparative example 2 (6.0 ± 0.8) d, comparative example 3 (5.6 ± 0.5) d
Through U inspection, patient's average course of disease comparing difference of embodiment group and comparative example three groups has statistical significance (P<0.01).
Claims (6)
1. treat a medicine for Pediatric Oral Emergency ulcer, it is characterized in that, comprise medicine for external use and oral medicine.
2. a kind of medicine for the treatment of Pediatric Oral Emergency ulcer according to claim 1, is characterized in that the described medicine for external use that comprises comprises: the extract of Spartina alterniflora;
Described oral medicine comprises: Fructus Tritici aestivi, Fructus Maydis, Herba Commelinae, Rhizoma Atractylodis, Cortex Phellodendri, Rhizoma Chuanxiong.
3. a kind of medicine for the treatment of Pediatric Oral Emergency ulcer according to claim 2, is characterized in that
Described oral medicine comprises: 8-11 part Fructus Tritici aestivi, 7-11 part Fructus Maydis, 15-23 part Herba Commelinae, 17-20 part Rhizoma Atractylodis, 9-11 part Cortex Phellodendri, 8-11 part Rhizoma Chuanxiong.
4. a kind of medicine for the treatment of Pediatric Oral Emergency ulcer according to claim 3, it is characterized in that the processing technology of the extract of described Spartina alterniflora is 1) by the Spartina alterniflora after vacuum drying, pulverize in pulverizer and obtain Spartina alterniflora's powder, Spartina alterniflora's powder is placed in the extraction kettle of supercritical extraction; 2) use supercritical CO 2 as solvent, the ethanol of concentration 70% ~ 80% does entrainer; 3) regulate extraction kettle to control at 25 ~ 35MPa by extracting pressure, temperature controls at 40 ~ 50 DEG C, and CO2 flow-control is at 10 ~ 15L/h, and extraction time controls at 1 ~ 2h, obtains brown paste Spartina alterniflora extract.
5. a kind of medicine for the treatment of Pediatric Oral Emergency ulcer according to claim 2, is characterized in that, described oral medicine technique is:
(1) Fructus Tritici aestivi, Fructus Maydis, Herba Commelinae, Rhizoma Atractylodis, Cortex Phellodendri, Rhizoma Chuanxiong mixing are carried out Crushing of Ultrafine, and sieved with 10 object screen clothes, discard thick raw material and form raw material; Add water Homogeneous phase mixing carry out homogenizing by 20 MPa homogenizers, then carries out spraying dry, obtain powdered granule;
(2) above-mentioned powdered granule is added 18 parts of distillation hydro-thermals to 70-75 DEG C, the cellulase then adding 0.0007 part carries out enzymolysis, and in this process, temperature maintains 70-75 DEG C,
100 minutes persistent period, obtain enzymolysis solution; Rapid temperature increases to 100 DEG C also keeps 5 minutes, is then cooled to 65-70 DEG C rapidly, and carries out homogenizing by three homogenizers successively, then carry out spraying dry, finally obtain powdered granule.
6. a kind of medicine for the treatment of Pediatric Oral Emergency ulcer according to claim 5, is characterized in that, the pressure of described three described homogenizers is followed successively by 40 MPas, 65 MPas, 55 MPas.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510115833.7A CN104645121A (en) | 2015-03-17 | 2015-03-17 | Medicine for treating oral ulcer in children |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510115833.7A CN104645121A (en) | 2015-03-17 | 2015-03-17 | Medicine for treating oral ulcer in children |
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| CN104645121A true CN104645121A (en) | 2015-05-27 |
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| CN201510115833.7A Pending CN104645121A (en) | 2015-03-17 | 2015-03-17 | Medicine for treating oral ulcer in children |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106072585A (en) * | 2016-07-14 | 2016-11-09 | 孙跃 | A kind of compound health nutritive powder |
| CN106174497A (en) * | 2016-07-14 | 2016-12-07 | 孙跃 | A kind of health care nutrition powder |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813833A (en) * | 2012-09-02 | 2012-12-12 | 慈静 | Chinese herbal preparation for treating hand-foot-and-mouth disease |
-
2015
- 2015-03-17 CN CN201510115833.7A patent/CN104645121A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813833A (en) * | 2012-09-02 | 2012-12-12 | 慈静 | Chinese herbal preparation for treating hand-foot-and-mouth disease |
Non-Patent Citations (3)
| Title |
|---|
| 孙秉华: "《中医元理与实践撷英》", 31 July 1991, 上海中医学院出版社 * |
| 徐宜厚等: "《当代中医皮肤科临床家丛书》", 31 October 2014, 中国医药科技出版社 * |
| 罗彩林等: ""大米草和互花米草药用价值研究进展"", 《亚太传统医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106072585A (en) * | 2016-07-14 | 2016-11-09 | 孙跃 | A kind of compound health nutritive powder |
| CN106174497A (en) * | 2016-07-14 | 2016-12-07 | 孙跃 | A kind of health care nutrition powder |
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Application publication date: 20150527 |