CN104000180A - Ginseng compound assisting in blood sugar level regulation and preparing method and application thereof - Google Patents
Ginseng compound assisting in blood sugar level regulation and preparing method and application thereof Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a ginseng compound assisting in blood sugar level regulation and the preparing method and application thereof. The ginseng compound comprises ginseng, propolis, rhizoma anemarrhenae, balsam pear, lotus leaves, poria cocos and radix ophiopogonis. The prepared ginseng compound can be used for assisting in blood sugar level regulation.
Description
Technical field
The present invention relates to a kind of composition for health product technology field, preparation method and its usage, be specifically related to a kind of ginseng composition, preparation method and the purposes aspect auxiliary hyperglycemic thereof.
Background technology
Ginseng is the dry root of Araliaceae herbaceos perennial ginseng (Panax ginseng C.A.Mey.), is a kind of valuable ingredient of traditional Chinese medicine of China's special product, records the earliest in Shennong's Herbal, classifies as top gradely, now records in Chinese pharmacopoeia.Sweet, the micro-hardship of ginseng, has and reinforces vital energy, and multiple arteries and veins is admittedly de-, reinforces the spleen to benefit the lung, and promotes the production of body fluid and nourishes blood, the effects such as intelligence development of calming the nerves.
Propolis is brown color or yellowish-brown solid block, heat deliquescing tool viscosity, peculiar aromatic odor, mainly contains immunoregulatory effect as health food, also have auxiliary anti-oxidant, regulate the health cares such as blood fat, blood pressure, blood sugar, auxiliary protection gastric mucosa.
The wind-weed is the dry rhizome of liliaceous plant wind-weed Anemarrhena asphodeloides Bge..Chinese pharmacopoeia is thought, wind-weed hardship, sweet, cold.Return lung, stomach, kidney channel, be usually used in fever caused by exogenous pathogenic factors, high hot polydipsia, lung heat is dry thirsty, osteopyrexia and fever, interior heat is quenched one's thirst, the dry constipation of intestines.
Balsam pear has another name called balsam pear, is cucurbitaceous plant, is annual climbing herb." the occupying diet spectrum with breath " of the Wang Meng of Qing Dynasty English said: " balsam pear is bitter cold clearly; Wash heat, improving eyesight, clears away heart-fire.Can salt down by sauce.---not food of syncope due to pathogenic cold person (the cold end).Ripe look red, and the sweet property of taste is flat, the nourishing liver of nourishing blood, the kidney tonifying of profit spleen ".Balsam pear has effect of clearing away heat and removing summer, nourishing blood and invigorating qi, kidney and spleen invigorating, nourishing liver for improving eyesight: the Charantin in balsam pear and bitter principle can improve a poor appetite, spleen benefiting and stimulating the appetite; Contained alkaloids substance quinine, has that diuresis is invigorated blood circulation, effect of anti-inflammatory antipyretic, the improving eyesight that clears away heart-fire; The fresh juice of balsam pear, the material that contains Charantin and similar insulin, has good hypoglycemic activity, is diabetic's ultimate food.
Lotus leaf is the dry leaf of nymphaeaceae plant lotus Nelumbo nucifera Gaertn., bitter, flat, return liver, spleen, stomach warp, the effects such as tool clearing away summer-heat and eliminating dampness, sending up the lucid yang, cooling blood and hemostasis, can be used for that hot summer weather polydipsia, summer heat damp diarrhea, splenasthenic diarrhea, blood-head are told nosebleed, the uterine bleeding of having blood in stool.
Poria cocos is the dry sclerotia of On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf, sweet, light, flat, the thoughts of returning home, lung, spleen, kidney channel, clearing damp and promoting diuresis, the peaceful heart of invigorating the spleen.
The tuber of dwarf lilyturf, is the dried root of liliaceous plant Ophiopogon tuber of dwarf lilyturf japonicus (L.f) Ker-Gawl., sweet, the micro-hardship of property, cool, and Yin-nourishing and body fluid promoting, relieving restlessness moistens the lung and relieve the cough, clears away heart-fire.Cure mainly consumption of body fluid caused by febrile disease, vexed, thirsty, dry throat lung heat, cough, pulmonary tuberculosis.
The present invention, according to theory of traditional Chinese medical science, analyzes the property of medicine of ginseng and relevant medicinal material, final definite with ginseng, propolis, the wind-weed, balsam pear, lotus leaf, Poria cocos, tuber of dwarf lilyturf seven flavor medicine material compatibility.Ginseng, large tonifying spleen lung vigour, in strong arteries and veins reason, promotes the production of body fluid to quench thirst; Propolis, a little less than qi-restoratives, only quenches one's thirst; The wind-weed, quenches one's thirst, hankers, and except perverse trend, tonifying for the deficiency, beneficial gas; Balsam pear, beneficial gas is antipyretic, and relieving restlessness is quenched the thirst; The tuber of dwarf lilyturf, cures mainly consumptive disease visitor heat, and dry mouth is thirsty, determines lung qi; Lotus leaf, summer heat relieving and dampness eliminating, relieving restlessness is quenched the thirst; Poria cocos, peace soul is reposed, clearing damp and promoting diuresis, strengthening the spleen and replenishing qi.Adopt people to participate in the wind-weed, balsam pear, lotus leaf, propolis, the tuber of dwarf lilyturf, Poria cocos compatibility, mend clear and execute full side, gas the moon of tonifying spleen and stomach lung, and the heat symptoms caused by an exopathgen of clear three warmers, the water of sharp internal organs is wet, and supplementing qi and nourishing yin is played, invigorating the spleen to clear away damp pathogen, the effect of relieving inflammation or internal heat and promoting the production of body fluid altogether by full side.
Summary of the invention
The invention provides a kind of new pharmaceutical composition, said composition has the function of auxiliary hyperglycemic.
The invention provides a kind of ginseng composition, said composition comprises ginseng, propolis, the wind-weed, balsam pear, lotus leaf, Poria cocos, the tuber of dwarf lilyturf.Wherein said composition comprises ginseng 1～40 weight portion, propolis 1～5 weight portion, the wind-weed 1～40 weight portion, balsam pear 1～40 weight portion, lotus leaf 1～40 weight portion, Poria cocos 1～40 weight portion, the tuber of dwarf lilyturf 1～40 weight portion.Be preferably said composition and comprise ginseng 1～20 weight portion; Propolis 1～2.5 weight portion; The wind-weed 10～40 weight portions; Balsam pear 1～20 weight portion, lotus leaf 1～20 weight portion, Poria cocos 1～20 weight portion, the tuber of dwarf lilyturf 1～20 weight portion; More preferably said composition comprises ginseng 2～20 weight portions; Propolis 2～2.5 weight portions; The wind-weed 20～40 weight portions; Balsam pear 2～20 weight portions, lotus leaf 2～10 weight portions, Poria cocos 2～20 weight portions, the tuber of dwarf lilyturf 2～20 weight portions.
The ginseng the invention provides in above-mentioned ginseng composition is fresh ginseng, sun-dried ginseng, red ginseng or dali ginseng.
The wind-weed the invention provides in above-mentioned ginseng composition is RHIZOMA ANEMARRHENAE with peet, or through salt system, frying, bran system or the wine means processed wind-weed after treatment.
The tuber of dwarf lilyturf the invention provides in above-mentioned ginseng composition is to meet the tuber of dwarf lilyturf medicinal material of standards of pharmacopoeia or process the tuber of dwarf lilyturf that the process such as the tuber of dwarf lilyturf, Zhu Maidong is concocted.
The invention provides the preparation method of above-mentioned ginseng composition.
The preparation method of inventor's ginseng composition is for to take ginseng, the wind-weed, balsam pear, lotus leaf, Poria cocos, the tuber of dwarf lilyturf by formula, after fragmentation, join in appropriate solvent and extract, wherein be extracted as to mix and extract or after extraction, mix again respectively, soak or decoct, filtering merging filtrate, it is for subsequent use that filtrate decompression is concentrated into thick liquid, then by propolis molten, add in above-mentioned concentrate, after mixing, carry out preparation; Or extract is concentrated into after certain volume, alcohol precipitation, gets supernatant dealcoholysis and is concentrated into magma, then propolis molten is added, and carries out preparation production.
The solvent adding is water or certain density ethanol.The weight ratio of the weight of solvent adding and ginseng, the wind-weed, balsam pear, lotus leaf, Poria cocos, the tuber of dwarf lilyturf is 10～50: 1, decocts number of times preferably 2～3 times.
Concentrate adds flavor enhancement seasoning, filling, sterilizing after can diluting as required, make health beverages or food and drink; Or be further condensed into clearly and add auxiliary material after cream, to granulate, packaging, makes instant capacity particle; Also can be made into the formulations such as paste, tablet, capsule, pill, powder, decoction, dripping pill or liquid oral.
Flavor enhancement used is white granulated sugar, rock sugar, xylitol, sorbierite, citric acid etc., preferably white granulated sugar, rock sugar, xylitol, citric acid.The consumption of flavor enhancement is generally 1～10% of formulation gross weight used, is preferably 3～5%.
The present invention also provides ginseng composition in the application of preparing in auxiliary hyperglycemic food or health products.
Detailed description of the invention:
Below in conjunction with embodiment, further set forth the present invention.Below be only the preferred embodiment of the present invention.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Embodiment 1: oral liquid
100 grams of ginsengs, 300 grams of the wind-weeds, 100 grams, balsam pear, 50 grams, lotus leaf, 100 grams, Poria cocos, 100 grams of the tuber of dwarf lilyturfs, add water 10 liters, decoct secondary, each 2 hours, merge decoction liquor, be concentrated into 4.5 liters, by 15 grams of moltens of propolis, add in above-mentioned concentrate, mix and add water to 10 liters, add 5% white granulated sugar seasoning, filling, sterilizing, obtain 100 bottles.
Embodiment 2: cream
200 grams of ginsengs, with 50% alcohol extract twice, 4 liters of each ethanol consumptions, merge extract.Separately get 400 grams of the wind-weeds, 100 grams, balsam pear, 100 grams, lotus leaf, 100 grams, Poria cocos, 100 grams of the tuber of dwarf lilyturfs, add water 15 liters, decoct secondary, each 2 hours, merge decoction liquor.Merge two kinds and extract solution, be concentrated into 4.5 liters, by 20 grams of moltens of propolis, add in above-mentioned concentrate, be concentrated into cream (density 1.1～1.5) clearly after mixing, filling, sterilizing, obtains 10 bottles.
Embodiment 3: particle
100 grams of ginsengs, 100 grams of the wind-weeds, 150 grams, balsam pear, 100 grams, lotus leaf, 150 grams, Poria cocos, 100 grams of the tuber of dwarf lilyturfs, add 10 liters of 50% ethanol, decoct secondary, each 2 hours, merge decoction liquor, be concentrated into 4.5L, by propolis 15g molten, add in above-mentioned concentrate, after mixing, be concentrated into cream clearly, added Icing Sugar to make auxiliary material by 1: 1, mix, granulate, packaging after drying, obtains 100 bags.
Embodiment 4: chewable tablets
200 grams of ginsengs, 100 grams of the wind-weeds, 150 grams, balsam pear, 100 grams, lotus leaf, 150 grams, Poria cocos, 100 grams of the tuber of dwarf lilyturfs, add water 15 liters, decoct secondary, each 2 hours, merge decoction liquor, be concentrated into 4.5 liters, by 10 grams of moltens of propolis, add in above-mentioned concentrate, after mixing, be concentrated into cream (density 1.1～1.5) clearly, added Icing Sugar to make auxiliary material by 1: 1, mix, after granulation, add 1% dolomol, compressing tablet obtains 1000, packaging.
Embodiment 5: capsule
300 grams of ginsengs, with 50% alcohol extract twice, 4 liters of each ethanol consumptions, merge extract.Separately get 100 grams of the wind-weeds, 100 grams, balsam pear, 100 grams, lotus leaf, 150 grams, Poria cocos, 100 grams of the tuber of dwarf lilyturfs, add water 10 liters, decoct secondary, each 2 hours, merge decoction liquor, be concentrated into 4.5 liters, by 10 grams of moltens of propolis, add in above-mentioned concentrate, after mixing, be concentrated into cream (density 1.1～1.5) clearly, added Icing Sugar to make auxiliary material by 1: 1, mix, filling capsule after granulating, drying, obtains 1000.
Embodiment 6: dripping pill
150 grams of ginsengs, 300 grams of the wind-weeds, 100 grams, balsam pear, 100 grams, lotus leaf, 150 grams, Poria cocos, 100 grams of the tuber of dwarf lilyturfs, add water 15 liters, decoct secondary, each 2 hours, merge decoction liquor, be concentrated into 4.5 liters, add ethanol to 75%, hold over night, filters, concentrated after dealcoholysis, by 10 grams of moltens of propolis, add in above-mentioned concentrate, be concentrated into dry, add polyethylene glycol or S-40 to make auxiliary material, dripping, oven dry, obtain 1000.
By " health food inspection and assessment technique specification " (version in 2003), the ginseng composition making by the formula rate in the present invention is carried out to auxiliary hyperglycemic functional observation.
Test example 1: the Functional observation of said composition aspect auxiliary hyperglycemic
1.1 test materials:
Be subject to the preparation of test product: by drafting recipe quantity proportion of composing, get ginseng, the wind-weed, balsam pear, lotus leaf, Poria cocos, the tuber of dwarf lilyturf and add together in solvent, decoct, filter, merging filtrate, it is for subsequent use that filtrate decompression is concentrated into thick liquid.Then by propolis molten, add in above-mentioned concentrate, mix.Every milliliter of concentrate is containing ginsengenin 20 .5mg.
Experimental animal: the healthy Kunming mouse of SPF level, body weight 22-25g, male and female half and half, are provided the quality certification number: SYXK (Shandong) 20030020 by natural drug Engineering Technical Research Centre experimental animal center, Shandong Province.
1.2 dosage are selected: this sample human body day recommended amounts is 360ml, is equivalent to 6ml/kgBW (body weight is in 60kg), establishes 3 dosage groups by 5,10,20 times of recommended amounts: 30,60 and 120ml/kgBW.Separately establish blank group, fill with the distilled water with same solvent volume, continuously gavage 30 days.
1.3 instruments and reagent: ONE TOUCH II type blood sugar monitoring instrument (Johnson & Johnson of the U.S.), alloxan (Sigma company)
1.4 test methods:
1.4.1 intact animal hypoglycemic test on an empty stomach
Get test mice, fasting 5h (freely drinking water), gets tail hematometry blood glucose value, is divided at random two groups by blood sugar level, is respectively blank group and given the test agent group (120ml/kgBW).Every group 10, the relatively fasting blood sugar after 2 groups of experimental animal 30d, observes the impact of tested material on normal mouse fasting blood-glucose.
1.4.2 the empty stomach hypoglycemic of alloxan hyperglycemia model mouse test
Get 50 of mouse, after fasting 24h, tail vein injection alloxan 120mg/kg, set up high sugared model, fasting 5h after 7 days, gets tail hematometry blood glucose value, get blood glucose value and be greater than the mouse of 10mmol/L, be divided at random four groups by blood sugar level, be respectively blank and three dosage groups, 30,60 and 120ml/kgBW, give continuously tested material 30 days, fasting 5h, gets tail hematometry blood sugar, each group mouse blood sugar value before and after comparative test.
1.4.3 alloxan hyperglycemia model animal carbohydrate tolerance test
After hypoglycemic off-test, each dosage group gives the sample of various dose, and model control group gives equal-volume distilled water, after 20min each group mouse all per os give the glucose solution of 20g/kg body weight, measure the blood glucose value to 0h, 0.5h, 2h after glucose.
1.5 test data statistics: carry out one-way analysis of variance with SPSS software kit.
2 result of the tests:
The impact of 2.1 ginseng compositions on normal mouse weightening finish and fasting blood sugar, in table 1.
Before and after the test of table 1. normal mouse, body weight and fasting blood sugar change
From table 1, give tested material 30 days, the body weight of given the test agent treated animal and fasting blood sugar and blank group compare, there was no significant difference (P > 0.05).
The impact of 2.2 ginseng compositions on alloxan induced hyperglycemia mice diabetic mice body weight, in table 2
The impact of table 2. ginseng composition on alloxan induced hyperglycemia mice weightening finish and fasting blood-glucose
Note: with the comparison of alloxan hyperglycemia model control group, * P < 0.05, * * P < 0.01; Fasting blood sugar × 100% before blood sugar decline percentage=(the rear fasting blood sugar of fasting blood sugar-experiment before experiment)/experiment.
From table 2, give tested material 30 days, each dosage treated animal weight gain no significant difference, but the 5 hours each dosage group of fasting blood sugar fasting blood-glucoses of fasting are all lower than control group, and middle and high dosage group and control group comparison, difference has statistical significance.Above result shows that this ginseng composition has the effect that reduces alloxan hyperglycemia model mouse fasting blood sugar.
The impact of 2.3 ginseng compositions on alloxan hyperglycemia model mouse sugar dosis tolerata, in table 3.
The impact of table 3. ginseng composition on alloxan hyperglycemia model mouse sugar dosis tolerata
Note: with model group comparison, * P < 0.05, * * P < 0.01; Area under the curve of blood glucose=0.25 × (0h blood glucose value+0.5h blood glucose value+3 × 2h blood glucose value).
From table 3, the each dosage group of ginseng composition mouse to glucose after 0, the blood glucose value of 0.5h, 2h is all lower than control group, with control group comparison, the difference of the Area under the curve of blood glucose of middle and high dosage has statistical significance.Experimental result shows, the resistance to sugar amount of this ginseng composition result of the test is positive.
Above-mentioned result of the test shows: the ginseng composition of preparing by the formula providing in the present invention, has no significant effect normal Mouse Weight and fasting blood sugar; Alloxan hyperglycemia model mouse there is is rising fasting blood-glucose rate of descent, reduces fasting blood sugar and reduction and give the effect of Area under the curve of blood glucose after glucose.
Claims (10)
1. a ginseng composition, is characterized in that said composition comprises ginseng, propolis, the wind-weed, balsam pear, lotus leaf, Poria cocos, the tuber of dwarf lilyturf.
2. ginseng composition according to claim 1, is characterized in that said composition comprises ginseng 1～40 weight portion, propolis 1～5 weight portion, the wind-weed 1～40 weight portion, balsam pear 1～40 weight portion, lotus leaf 1～40 weight portion, Poria cocos 1～40 weight portion, the tuber of dwarf lilyturf 1～40 weight portion.
3. ginseng composition according to claim 2, is characterized in that said composition comprises ginseng 1～20 weight portion; Propolis 1～2.5 weight portion; The wind-weed 10～40 weight portions; Balsam pear 1～20 weight portion, lotus leaf 1～20 weight portion, Poria cocos 1～20 weight portion, the tuber of dwarf lilyturf 1～20 weight portion.
4. ginseng composition according to claim 3, is characterized in that said composition comprises ginseng 2～20 weight portions; Propolis 2～2.5 weight portions; The wind-weed 20～40 weight portions; Balsam pear 2～20 weight portions, lotus leaf 2～10 weight portions, Poria cocos 2～20 weight portions, the tuber of dwarf lilyturf 2～20 weight portions.
5. according to the arbitrary described ginseng composition of claim 1～4, it is characterized in that described ginseng is fresh ginseng, sun-dried ginseng, red ginseng or dali ginseng.
6. according to the arbitrary described ginseng composition of claim 1～4, it is characterized in that the described wind-weed is RHIZOMA ANEMARRHENAE with peet, or through salt system, frying, bran system or the wine means processed wind-weed after treatment.
7. according to the arbitrary described ginseng composition of claim 1～4, it is characterized in that the described tuber of dwarf lilyturf is to meet the tuber of dwarf lilyturf medicinal material of standards of pharmacopoeia or process the tuber of dwarf lilyturf that the process such as the tuber of dwarf lilyturf, Zhu Maidong is concocted.
8. the preparation method of the arbitrary described ginseng composition of claim 1～4, it is characterized in that: take ginseng, the wind-weed, balsam pear, lotus leaf, Poria cocos and the tuber of dwarf lilyturf by formula, after fragmentation, join in appropriate solvent and extract, be wherein extracted as to mix and extract or after extraction, mix again respectively, soak or decoct, filter, merging filtrate, it is for subsequent use that filtrate decompression is concentrated into thick liquid, then by propolis molten, add in above-mentioned concentrate, after mixing, carry out preparation; Or extract is concentrated into after certain volume, alcohol precipitation, gets supernatant dealcoholysis and is concentrated into magma, then propolis molten is added, and carries out preparation.
9. according to the arbitrary described ginseng composition of claim 1～4, it is characterized in that said composition exists with the form of paste, tablet, capsule, pill, granule, powder, decoction, dripping pill or liquid oral.
According to the arbitrary described ginseng composition of claim 1～4 in the application of preparing in auxiliary hyperglycemic food or health products.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104757356A (en) * | 2015-03-11 | 2015-07-08 | 陈航 | Auxiliary blood sugar lowering composition, and preparation method, preparations and application thereof |
| CN108935719A (en) * | 2018-08-31 | 2018-12-07 | 广东环境保护工程职业学院 | Shellfish enzymolysis liquid beans custard and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104757356A (en) * | 2015-03-11 | 2015-07-08 | 陈航 | Auxiliary blood sugar lowering composition, and preparation method, preparations and application thereof |
| CN108935719A (en) * | 2018-08-31 | 2018-12-07 | 广东环境保护工程职业学院 | Shellfish enzymolysis liquid beans custard and preparation method thereof |
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Application publication date: 20140827 |